US20080161769A1 - Capillary fill test device - Google Patents
Capillary fill test device Download PDFInfo
- Publication number
- US20080161769A1 US20080161769A1 US11/954,131 US95413107A US2008161769A1 US 20080161769 A1 US20080161769 A1 US 20080161769A1 US 95413107 A US95413107 A US 95413107A US 2008161769 A1 US2008161769 A1 US 2008161769A1
- Authority
- US
- United States
- Prior art keywords
- sample
- conduit
- liquid
- receiving chamber
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/12—Dippers; Dredgers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
Definitions
- the chamber can be included in devices which have a filling time greater than the time taken for the user to merely present the source of liquid to the device and to then remove it, for example a filling time of one second or more.
- the inlet end of the sample-receiving chamber opens into the major and minor external surfaces of the body.
- the major and minor surfaces may be generally perpendicular to each another, and the minor surface may have a significantly smaller surface area than the major surface.
- the minor surface may be an end or side wall and the major surface may be a top surface (when the body is a rectilinear strip or wedge- or disc-shaped for example). In such instances, the sides of the device cannot be considered to be major surfaces.
- the minor surface may be an end wall and the major surface may be an outer surface (when the body is cylindrical for example). Regardless of the shape of the body, the opening of the inlet end may be preferably continuous in the major and minor surfaces.
- the sample-receiving chamber may taper from the inlet end to the outlet end, and may be generally V- or U-shaped.
- the width of the inlet end may be approximately 10-15 times the width of the outlet end, and may be 0.5-1.5 times the length of the sample-receiving portion.
- the conduit may be arranged so as to allow the liquid sample to move by capillary action, although other forces can act on the liquid such as hydrostatic pressure and/or positive displacement to cause it to move along the conduit.
- the maximum dimension of the conduit may be less than 0.5, 0.4 or 0.3 mm. In one embodiment, the maximum dimension may be in the range of from 0.25 to 0.3 mm and may be about 0.28 mm.
- the conduit may have a Reynolds number less than about 2000 (i.e., the Reynolds lower critical number for pipe flow), this number being calculated according to the formula:
- the device may be made by laminating two or more layers.
- a base layer 7 forms the bottom surface of the chamber 5 and channel 6 .
- a middle layer 8 has cuts therethrough to form the walls of the chamber 5 and channel 6 .
- a top layer 9 forms the top surface of the channel 6 .
- top layer 9 partially overlays the sample receiving chamber 5 that is formed by the cut sides of layer 8 and the top surface of base layer 7 .
- a plan view of FIG. 7 is shown in FIG. 8 and a section along line X-X of FIG. 8 is shown in FIG. 9 .
- dimension A is 0.275 mm
- B is 3 mm
- C is 0.3 mm
- D is 2.5 mm
- E is 0.175 mm
- F is 2 mm.
- a laminated device in accordance with the present invention may be made as is described in UK Patent Application No. 0327094.9, the disclosure of which is incorporated by reference.
Abstract
A device for receiving a sample of liquid, such as a sample of bodily liquid which is to be subjected to further analysis, may include a body having at least a major surface and a minor surface. A sample-receiving chamber may be located in the body and may have an inlet end which opens into the major and minor surfaces of the body. A conduit may be located in the body, extending from the outlet end of the chamber, and may be arranged so as to allow the liquid to pass from the outlet end into the conduit by capillary action.
Description
- This application is a division of U.S. application Ser. No. 10/930,717, filed Aug. 31, 2004, which claims the benefit of U.S. Provisional Pat. App. Ser. No. 60/509,093, filed Oct. 6, 2003, the contents of which are hereby incorporated herein by reference.
- Known fluid sample-receiving devices used for blood glucose monitoring take up finger stick blood very rapidly. This is not a problem, as the measurement undertaken does not require actively moving or capillary-driven blood.
- However, there exists a problem with the application of finger prick blood onto diagnostic devices for use where the sample is required to be actively moved or capillary driven along the device.
- Devices are disclosed for receiving a sample of liquid, and in particular, but not exclusively, for receiving a sample of bodily liquid such as blood so that it can be subjected to an assay.
- In an embodiment, a device for receiving a sample of liquid may include a body, a sample-receiving recess, and a conduit. The body may have at least opposed first and second major outwardly facing surfaces each defining a periphery, and a peripheral wall joining the peripheries of the major surfaces. A conduit may extend from the outlet of the recess into an interior of the body between the first and second major surfaces. The conduit may be arranged so as to allow the liquid to pass from the outlet into the conduit by capillary action, and the conduit may have a maximum width no greater than the width of the recess at the outlet end and a conduit axis that runs along its length. A sample-receiving recess may be located inside of the first major surface of the body and may be defined in part by a surface substantially parallel to the first major surface and being outwardly exposed along an axis perpendicular to the conduit axis. The recess may include an inlet defined in part by the peripheral wall and an outlet spaced apart from the peripheral wall within the body, and a width that decreases from the inlet end to the outlet end.
- In an embodiment, a device for receiving a sample of liquid may include a body having at least a major surface and a minor surface, a sample-receiving chamber located in the body and having an inlet end which opens into the major and minor surfaces of the body, and a conduit located in the body and extending from the outlet end of the chamber, the conduit being arranged so as to allow the liquid to pass from the outlet end into the conduit by capillary action.
- In an embodiment, a device for receiving a sample of liquid may include a body having at least an end wall, a generally V-shaped sample-receiving chamber located in the body and having an inlet end which opens into the end wall of the body, and a conduit located in the body and extending from the outlet end of the chamber, the conduit being arranged so as to allow the liquid to pass from the outlet end into the conduit by capillary action.
-
FIG. 1 is a partial isometric view of one embodiment of a device; -
FIG. 2 is a plan view of the device ofFIG. 1 ; -
FIG. 3 is a section along the line X-X inFIG. 2 ; -
FIG. 4 is an isometric view of a section along the line X-X inFIG. 2 ; -
FIGS. 5 a and b are plan views of two embodiments of devices; -
FIG. 6 is a graph plotting fill time against the volume of whole blood added to a device; -
FIG. 7 is a partial isometric view of the front end of another embodiment of the invention; -
FIG. 8 is a plan view of the device ofFIG. 7 ; and -
FIG. 9 is a section along line X-X inFIG. 8 . - A user may deposit a liquid sample into or onto the device at the sample-receiving chamber. The sample-receiving chamber may include an inlet end, such as a notch, that opens onto two surfaces of the device. This geometry can provide an easy target for a user to position the source of fluid, such as a pricked finger expressing a drop of blood, onto the device. The device can facilitate delivery of the liquid into the conduit, for example to allow an assay to be performed at another area of the device. This can be particularly helpful for diagnostic devices for blood samples where the assay result is not produced instantly, for example immunoassays requiring immunobinding of reagents to occur or biological enzyme reactions which link the measurement of blood clotting time. Safe delivery of the fluid into the conduit can also facilitate processing of the sample where diagnosis or assay has to be carried out remote from the sample-receiving chamber.
- The sample-receiving chamber may act as a liquid reservoir which can thereafter supply the rest of the device with sufficient liquid even in the absence of the user maintaining contact with the device and removes the need for the user to maintain constant contact with the device during the filling process. This is especially advantageous for older people who might find it difficult to maintain constant contact with a device which may be of small dimensions. Furthermore, it reduces the possibility of device malfunction as removal of the liquid source at any time during filling may result in underfilling or the introduction of air bubbles.
- The chamber can be included in devices which have a filling time greater than the time taken for the user to merely present the source of liquid to the device and to then remove it, for example a filling time of one second or more.
- A disclosed device may be for use in chemical (especially biochemical or clinical) test procedures, often known as a capillary fill test device. Capillary fill test devices are typically used in combination with a second device, typically an electronic instrument designed to detect the existence, or the extent of, a predetermined interaction of the liquid sample, or one or more analytes in the liquid sample, with one or more other components of the device. Such components may be an electrode structure and/or one or more fluid-interactive or analyte-reactive compositions. The electronic instrument may be used to assess the sample liquid in the device, most typically by photometric or electrometric techniques after a predetermined sample reaction period. Capillary fill devices are often designed to be positioned in the electronic instrument before the device is loaded with the fluid sample. When the capillary fill device is properly positioned in the instrument, the sample-receiving chamber is external to the instrument and accessible to the user, and the area of the device where analysis takes place is located in electrical or phototransmissive/photoreflective communication with a sensor element capable of detecting and reporting a condition or change of condition of the liquid after or during a predetermined time period. A volume of test liquid may be delivered to the sample-receiving chamber to be drawn by capillary action (and possibly other forces) into and through the conduit and into the area of the device where analysis takes place. The instrument can be equipped with sensors to detect the flow of the test liquid through the conduit; optionally the instrument can be designed to use such detected flow to initiate a test sequence. In some liquid testing applications, for example, in certain instruments designed for use with capillary fill devices for determining coagulation characteristics of blood, the rate of flow of the liquid through the capillary flow conduit may be sensed and used as a parameter in the test sequence. In such testing applications, the conduit serves additionally to provide means for measuring flow characteristics, i.e., viscosity, of the test liquid as it is delivered to the test area.
- The body of the device may be a generally rectilinear strip, as may be conventional for capillary test devices. Such strips may have end walls, side walls and/or top and bottom surfaces or parts thereof which are not parallel to each other. Alternatively, it may be cylindrical, wedge-shaped, disc-shaped, or any other convenient shape, provided that it has major and minor surfaces into which the inlet end of the sample-receiving chamber opens.
- The inlet end of the sample-receiving chamber opens into the major and minor external surfaces of the body. The major and minor surfaces may be generally perpendicular to each another, and the minor surface may have a significantly smaller surface area than the major surface. The minor surface may be an end or side wall and the major surface may be a top surface (when the body is a rectilinear strip or wedge- or disc-shaped for example). In such instances, the sides of the device cannot be considered to be major surfaces. In one embodiment, the minor surface may be an end wall and the major surface may be an outer surface (when the body is cylindrical for example). Regardless of the shape of the body, the opening of the inlet end may be preferably continuous in the major and minor surfaces.
- The portion of the sample-receiving chamber which opens into the minor surface may be less than the portion which opens into the major surface. For example, the area of the chamber opening onto the major surface may be 1.3 to 3 times, in one embodiment 1.6 times, the area of the chamber opening into the minor surface.
- The sample-receiving chamber may taper from the inlet end to the outlet end, and may be generally V- or U-shaped. For example, the width of the inlet end may be approximately 10-15 times the width of the outlet end, and may be 0.5-1.5 times the length of the sample-receiving portion.
- The conduit may be arranged so as to allow the liquid sample to move by capillary action, although other forces can act on the liquid such as hydrostatic pressure and/or positive displacement to cause it to move along the conduit. For example, when viewed in section perpendicular to the longitudinal axis, the maximum dimension of the conduit may be less than 0.5, 0.4 or 0.3 mm. In one embodiment, the maximum dimension may be in the range of from 0.25 to 0.3 mm and may be about 0.28 mm. The conduit may have a Reynolds number less than about 2000 (i.e., the Reynolds lower critical number for pipe flow), this number being calculated according to the formula:
-
- where Re=Reynolds number, ρ=Fluid density, V=Fluid velocity, d=length scale, and η=dynamic viscosity. A Reynolds number of 2000 or less will cause the conduit (which may be considered to be a microstructure or microchannel) to be filled passively by surface tension (capillarity) alone.
- At least the sample-receiving chamber and the conduit are conveniently coated with a hydrophilic coating, which may be on any or all of the walls thereof. The coating may provide a contact angle of 90° or less, 30° or less, or 20° or less. The contact angle may be in the range of from 5 to 15° and may be 11°. It may provide a contact angle of 110° provided that it is applied only on one wall. The contact angle may be determined as described at page 46 of “Fundamental and Applications of Microfluidics”, Nguyen & Werely, Artech House, 30 Sep. 2002, ISBN 1580533434.
- The liquid to be sampled can be any liquid. In a preferred embodiment, the liquid may be a bodily liquid, such as whole blood, plasma, interstitial fluid, cerebrospinal fluid (CSF), urine, serum, saliva, tears and sweat.
- A disclosed device may be used to receive blood which may be subjected to the measurement of blood coagulation and/or other hemostasis measurements, such as prothrombin times. They may also be used in to receive bodily liquids which are subjected to immunoassays, hormone measurements, detection of cardiology markers, detection of cancer markers, detection of infectious disease agents, etc. These tests may be carried out in an assay chamber of the device.
- Preferred features of an embodiment are as for other embodiments mutatis mutandis.
- Referring to
FIGS. 1-4 , adevice 1 is partially shown.Device 1 may have a top (major)surface 2, and an end (minor)surface 3 and respective side surfaces 4. The bottom surface of the device cannot be seen.Device 1 tapers towardsend surface 3. In some embodiments,device 1 does not have this taper and, in others, it may have a hammerhead shape. A sample-receivingchamber 5, defined at least in part by surface S, may be recessed in thedevice 1 such that it opens intotop surface 2 and endsurface 3. In an alternative embodiment, sample-receivingchamber 5 opens intotop surface 2 and aside surface 4. - The
sample receiving chamber 5 may have an inlet end, and an outlet end (having width Y) which opens into aconduit 6. The inlet end may be substantially larger than the outlet end such that the width W ofchamber 5 tapers towards to the outlet end in a V-shape. Alternative generally V- or U-shaped chambers are shown inFIGS. 5 a and b. In one embodiment,sample receiving chamber 5 tapers such that the dimension A decreases in value from the inlet end to the outlet end. In general, the sample chamber may be of any shape and dimensions so long as a liquid sample is able to pass from the inlet end to the outlet end by capillary action. In order to speed the passage of fluid within the chamber, the shape and dimensions of the chamber may be chosen such that the capillarity at the outlet end is greater than the capillarity at the inlet end. Aconduit axis 10 may be defined along the conduit. The sample-receiving surface may be outwardly exposed along anaxis 11 perpendicular to the conduit axis. - As shown in the Figures,
conduit 6 is a channel which may be recessed into thetop surface 2. Although not shown,conduit 6 may be closed by means of a laminar layer laid ontotop surface 2. The layer may overlay all or a part of the sample-receivingchamber 5, although it is not preferred if it overlays all of sample-receivingchamber 5 because the additional friction provided by the layer over thechamber 5 reduces the speed at which liquid can travel downconduit 6. Partial overlay of the sample-receivingchamber 5 may be advantageous to break the surface tension of the sample as it is applied to the sample receiving chamber and aid entry of the sample intoconduit 6. Partial overlay also allows for the addition of a sample volume that is larger than could be added to sample receiving chamber that is overlayed. The other end ofconduit 6 leads to an area of the device where an analysis or assay of the liquid can be carried out (not shown). - In one embodiment, dimension A may be 0.9 mm, B may be 2.5 mm, C may be 0.2 mm, D may be 3 mm and E may be 0.2 mm.
- Devices can be prepared using a variety of techniques known in the art. For example, injection molding or microinjection molding using suitable molds can be used. Alternatively, embossing techniques where the structure may be pressed into a material and techniques using silicon etching and/or photolithography can also be used.
- As yet a further alternative, the device may be made by laminating two or more layers. Referring to
FIG. 7 , such a device may comprise three layers. In the depicted embodiment, abase layer 7 forms the bottom surface of thechamber 5 andchannel 6. Amiddle layer 8 has cuts therethrough to form the walls of thechamber 5 andchannel 6. A top layer 9 forms the top surface of thechannel 6. In the illustrated embodiment, top layer 9 partially overlays thesample receiving chamber 5 that is formed by the cut sides oflayer 8 and the top surface ofbase layer 7. A plan view ofFIG. 7 is shown inFIG. 8 and a section along line X-X ofFIG. 8 is shown inFIG. 9 . - In one embodiment, dimension A is 0.275 mm, B is 3 mm, C is 0.3 mm, D is 2.5 mm, E is 0.175 mm and F is 2 mm.
- A laminated device in accordance with the present invention may be made as is described in UK Patent Application No. 0327094.9, the disclosure of which is incorporated by reference.
- Polystyrene devices were injection molded with a sample-receiving chamber as shown in
FIGS. 1-4 . These devices were then treated with plasma enhanced chemical vapor deposition to coat the surface with a hydrophilic molecular layer such that the contact angle following treatment was approximately 11°. Techniques for doing this are well known to those skilled in the art. The devices were then laminated with a hydrophilic laminate (contact angle 11°) such that the laminate covered theconduit 6, but not the sample-receivingchamber 5. - Various volumes of fresh whole blood were pipetted onto the sample-receiving chamber 5 (blood from a finger prick source can also be applied directly to the sample-receiving chamber). The time taken for the blood to travel down the
conduit 6 to a fixed point was determined. The measurements are listed in Table 1. These fill times plotted against the volume of whole blood added to the device are shown inFIG. 6 . - It can be seen that volumes of 5 μl or less result in fill times of greater than about 20 seconds, and volumes of 7 μl or more have little effect on fill time.
-
TABLE 1 Blood Volume Fill Time Pipetted (μl) (seconds) 4.5 33.4 4.75 21.7 5 17 5 16.9 6 16.6 6 15.7 7 13.8 7 12.4 10 12.6
Claims (2)
1. A device for receiving a sample of liquid, comprising:
a body having at least an end wall;
a generally V-shaped sample-receiving chamber located in the body and having an inlet end which opens into the end wall of the body; and
a conduit located in the body and extending from the outlet end of the chamber, the conduit being arranged so as to allow the liquid to pass from the outlet end into the conduit by capillary action.
2. A device for receiving a sample of liquid, comprising:
a rectilinear body having at least a top surface and an end wall;
a sample-receiving chamber located in the body and having:
an inlet end which opens into the top surface and the end wall of the body; and
and an outlet end, the sample-receiving chamber tapering from the inlet end to the outlet end; and
a conduit located in the body and extending from the outlet end of the chamber, the conduit being arranged so as to allow the liquid to pass from the outlet end into the conduit by capillary action;
wherein the sample-receiving chamber and the conduit are coated with a hydrophilic coating, providing a contact angle of 90 degrees or less.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/954,131 US20080161769A1 (en) | 2003-09-01 | 2007-12-11 | Capillary fill test device |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0320470A GB0320470D0 (en) | 2003-09-01 | 2003-09-01 | Device |
GB0320470.8 | 2003-09-01 | ||
US50909303P | 2003-10-06 | 2003-10-06 | |
US10/930,717 US7305896B2 (en) | 2003-09-01 | 2004-08-31 | Capillary fill test device |
US11/954,131 US20080161769A1 (en) | 2003-09-01 | 2007-12-11 | Capillary fill test device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/930,717 Division US7305896B2 (en) | 2003-09-01 | 2004-08-31 | Capillary fill test device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080161769A1 true US20080161769A1 (en) | 2008-07-03 |
Family
ID=34276817
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/930,717 Active 2024-11-05 US7305896B2 (en) | 2003-09-01 | 2004-08-31 | Capillary fill test device |
US11/954,131 Abandoned US20080161769A1 (en) | 2003-09-01 | 2007-12-11 | Capillary fill test device |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/930,717 Active 2024-11-05 US7305896B2 (en) | 2003-09-01 | 2004-08-31 | Capillary fill test device |
Country Status (6)
Country | Link |
---|---|
US (2) | US7305896B2 (en) |
EP (1) | EP1667581A1 (en) |
JP (1) | JP2007504438A (en) |
AU (1) | AU2004268431A1 (en) |
CA (1) | CA2537091A1 (en) |
WO (1) | WO2005020817A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110081275A1 (en) * | 2009-10-06 | 2011-04-07 | Institut Fur Mikrotechnik Mainz Gmbh | Microfluidic structure |
US20220099668A1 (en) * | 2019-01-11 | 2022-03-31 | Guangzhou Wondfo Biotech Co., Ltd. | Immunochromatographic assay device |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
ES2336081T3 (en) | 2001-06-12 | 2010-04-08 | Pelikan Technologies Inc. | SELF-OPTIMIZATION PUNCTURE DEVICE WITH MEANS OF ADAPTATION TO TEMPORARY VARIATIONS IN CUTANEOUS PROPERTIES. |
WO2002100254A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
DE60238119D1 (en) | 2001-06-12 | 2010-12-09 | Pelikan Technologies Inc | ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
ATE476137T1 (en) | 2003-05-30 | 2010-08-15 | Pelikan Technologies Inc | METHOD AND DEVICE FOR INJECTING LIQUID |
DK1633235T3 (en) | 2003-06-06 | 2014-08-18 | Sanofi Aventis Deutschland | Apparatus for sampling body fluid and detecting analyte |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | Method and apparatus for an improved sample capture device |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
GB0324641D0 (en) * | 2003-10-22 | 2003-11-26 | Unipath Ltd | Coagulation detection method |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
CA2583406A1 (en) * | 2004-09-20 | 2007-01-04 | Boston Microfluidics | Microfluidic device for detecting soluble molecules |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
EP1954197A2 (en) * | 2005-11-22 | 2008-08-13 | Stichting Top Institute Food and Nutrition | Sampling device for in vivo sampling of liquids from the gastrointestinal tract, process for the production thereof and mould or mask for use in the production process |
CN101437616B (en) * | 2006-05-03 | 2012-05-23 | Ncl新概念实验室有限责任公司 | Device and method for chemical, biochemical, biological and physical analysis, reaction, assay and more |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
KR101104400B1 (en) * | 2009-06-02 | 2012-01-16 | 주식회사 세라젬메디시스 | Biosensor for measuring biomaterial |
JP5507991B2 (en) * | 2009-12-15 | 2014-05-28 | 日本電信電話株式会社 | applicator |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
MX2012014620A (en) * | 2010-06-30 | 2013-02-07 | Hoffmann La Roche | Methods for manufacturing a dual biosensor test strip. |
US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
CA2830010A1 (en) * | 2011-03-15 | 2012-09-20 | Carclo Technical Plastics Limited | Sample metering |
JP6012198B2 (en) * | 2012-02-22 | 2016-10-25 | 日精株式会社 | Capillary blood collection tool |
US8992750B1 (en) | 2012-07-02 | 2015-03-31 | Roche Diagnostics Operations, Inc. | Biosensor and methods for manufacturing |
US9874556B2 (en) | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
US9427184B2 (en) | 2012-09-06 | 2016-08-30 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
EP4098239A1 (en) | 2012-09-06 | 2022-12-07 | Labrador Diagnostics LLC | Systems, devices, and methods for bodily fluid sample collection |
US9636062B2 (en) | 2012-09-06 | 2017-05-02 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
US9386948B2 (en) | 2012-12-05 | 2016-07-12 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample transport |
US10248765B1 (en) | 2012-12-05 | 2019-04-02 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection, transport, and handling |
US9599615B2 (en) | 2013-03-13 | 2017-03-21 | Symbolics, Llc | Lateral flow assays using two dimensional test and control signal readout patterns |
KR20150133774A (en) | 2013-03-15 | 2015-11-30 | 테라노스, 인코포레이티드 | Methods and devices for sample collection and sample separation |
JP6312440B2 (en) * | 2013-04-03 | 2018-04-18 | 日精株式会社 | Capillary blood collection tool |
WO2015138818A1 (en) | 2014-03-12 | 2015-09-17 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
FR3033407B1 (en) * | 2015-03-02 | 2017-03-31 | Avalun | DEVICE FOR COLLECTING A LIQUID SAMPLE BY CAPILLARITY. |
US10371606B2 (en) | 2015-07-21 | 2019-08-06 | Theraos IP Company, LLC | Bodily fluid sample collection and transport |
US11247208B2 (en) | 2015-09-09 | 2022-02-15 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
CN108430564B (en) * | 2015-12-04 | 2022-01-11 | 艾希莱恩公司 | Microneedle and chip |
PL3397387T3 (en) * | 2015-12-29 | 2021-11-22 | Opko Diagnostics, Llc | Fluid collection device and related methods |
US11857966B1 (en) | 2017-03-15 | 2024-01-02 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
WO2018183896A1 (en) * | 2017-03-31 | 2018-10-04 | Forward Biotech, Inc. | Device for measuring fluid volumes |
Citations (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3406573A (en) * | 1967-03-10 | 1968-10-22 | Dade Reagents Inc | Capillary pipette and adapter-holder therefor |
US3603156A (en) * | 1970-02-04 | 1971-09-07 | Gradko Glass Lab Inc | Disposable dilution system |
US3952599A (en) * | 1972-05-18 | 1976-04-27 | Ayres Waldemar A | Fractional-fill capillary pipette and method |
US5141868A (en) * | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
US5278079A (en) * | 1992-09-02 | 1994-01-11 | Enzymatics, Inc. | Sealing device and method for inhibition of flow in capillary measuring devices |
US5975153A (en) * | 1998-02-13 | 1999-11-02 | Roche Diagnostics Corporation | Capillary fill test device with improved fluid delivery |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US6098471A (en) * | 1996-11-20 | 2000-08-08 | Boule Medical Ab | Diluting and measuring device for particle counting |
USD435300S (en) * | 1999-12-16 | 2000-12-19 | Roche Diagnostics Corporation | Biosensor |
USD441089S1 (en) * | 2000-06-19 | 2001-04-24 | Roche Diagnostics Corporation | Biosensor |
US6232129B1 (en) * | 1999-02-03 | 2001-05-15 | Peter Wiktor | Piezoelectric pipetting device |
US6270637B1 (en) * | 1997-12-05 | 2001-08-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
US20010036424A1 (en) * | 2000-02-18 | 2001-11-01 | Olympus Optical Co., Ltd. | Liquid pipetting apparatus and micro array manufacturing apparatus |
US6387328B1 (en) * | 1997-07-01 | 2002-05-14 | Boule Medical Ab | Disposable sampling device for particle counting apparatus |
US6413395B1 (en) * | 1999-12-16 | 2002-07-02 | Roche Diagnostics Corporation | Biosensor apparatus |
US6428664B1 (en) * | 2000-06-19 | 2002-08-06 | Roche Diagnostics Corporation | Biosensor |
US6447657B1 (en) * | 2000-12-04 | 2002-09-10 | Roche Diagnostics Corporation | Biosensor |
US20020160520A1 (en) * | 2001-03-16 | 2002-10-31 | Phoenix Bioscience | Silicon nano-collection analytic device |
US6488828B1 (en) * | 2000-07-20 | 2002-12-03 | Roche Diagnostics Corporation | Recloseable biosensor |
US20030028125A1 (en) * | 2001-08-06 | 2003-02-06 | Yuzhakov Vadim V. | Physiological sample collection devices and methods of using the same |
US20030047011A1 (en) * | 2000-02-25 | 2003-03-13 | Ulrich Diermann | Micro perfusion device comprising a collecting container |
US6540890B1 (en) * | 2000-11-01 | 2003-04-01 | Roche Diagnostics Corporation | Biosensor |
US20030070498A1 (en) * | 2001-09-06 | 2003-04-17 | Yasuhiro Ohyama | Automatic sample analyzer and its components |
US6557427B2 (en) * | 2000-05-24 | 2003-05-06 | Micronics, Inc. | Capillaries for fluid movement within microfluidic channels |
US6645359B1 (en) * | 2000-10-06 | 2003-11-11 | Roche Diagnostics Corporation | Biosensor |
US6662439B1 (en) * | 1999-10-04 | 2003-12-16 | Roche Diagnostics Corporation | Laser defined features for patterned laminates and electrodes |
US6707554B1 (en) * | 1998-09-29 | 2004-03-16 | Roche Diagnostics Gmbh | Method for the photometric analysis of test elements |
US6755949B1 (en) * | 2001-10-09 | 2004-06-29 | Roche Diagnostics Corporation | Biosensor |
US6767440B1 (en) * | 2001-04-24 | 2004-07-27 | Roche Diagnostics Corporation | Biosensor |
US20040197231A1 (en) * | 2001-07-27 | 2004-10-07 | Koji Katsuki | Analyzing instrument |
US6814844B2 (en) * | 2001-08-29 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor with code pattern |
US6814843B1 (en) * | 2000-11-01 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor |
US6866758B2 (en) * | 2002-03-21 | 2005-03-15 | Roche Diagnostics Corporation | Biosensor |
US7073246B2 (en) * | 1999-10-04 | 2006-07-11 | Roche Diagnostics Operations, Inc. | Method of making a biosensor |
US20060233671A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US20060233672A1 (en) * | 2003-09-19 | 2006-10-19 | Reed Mark T | High density plate filler |
US20060233673A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US7128876B2 (en) * | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
US20070003444A1 (en) * | 2003-11-21 | 2007-01-04 | Steven Howell | Laminated device |
US20070014694A1 (en) * | 2003-09-19 | 2007-01-18 | Beard Nigel P | High density plate filler |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8700277A (en) * | 1987-02-05 | 1988-09-01 | Livestock Control Holding | DEVICE FOR VACUUM AND DROPPING A LIQUID. |
JP2000232972A (en) * | 1999-02-15 | 2000-08-29 | Daikin Ind Ltd | Sample spot-sticking instrument |
-
2004
- 2004-08-27 JP JP2006524423A patent/JP2007504438A/en not_active Withdrawn
- 2004-08-27 AU AU2004268431A patent/AU2004268431A1/en not_active Abandoned
- 2004-08-27 WO PCT/GB2004/003683 patent/WO2005020817A1/en active Application Filing
- 2004-08-27 EP EP04768238A patent/EP1667581A1/en not_active Withdrawn
- 2004-08-27 CA CA002537091A patent/CA2537091A1/en not_active Abandoned
- 2004-08-31 US US10/930,717 patent/US7305896B2/en active Active
-
2007
- 2007-12-11 US US11/954,131 patent/US20080161769A1/en not_active Abandoned
Patent Citations (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3406573A (en) * | 1967-03-10 | 1968-10-22 | Dade Reagents Inc | Capillary pipette and adapter-holder therefor |
US3603156A (en) * | 1970-02-04 | 1971-09-07 | Gradko Glass Lab Inc | Disposable dilution system |
US3952599A (en) * | 1972-05-18 | 1976-04-27 | Ayres Waldemar A | Fractional-fill capillary pipette and method |
US5141868A (en) * | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
US5278079A (en) * | 1992-09-02 | 1994-01-11 | Enzymatics, Inc. | Sealing device and method for inhibition of flow in capillary measuring devices |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US6098471A (en) * | 1996-11-20 | 2000-08-08 | Boule Medical Ab | Diluting and measuring device for particle counting |
US6387328B1 (en) * | 1997-07-01 | 2002-05-14 | Boule Medical Ab | Disposable sampling device for particle counting apparatus |
US6270637B1 (en) * | 1997-12-05 | 2001-08-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
US5975153A (en) * | 1998-02-13 | 1999-11-02 | Roche Diagnostics Corporation | Capillary fill test device with improved fluid delivery |
US6707554B1 (en) * | 1998-09-29 | 2004-03-16 | Roche Diagnostics Gmbh | Method for the photometric analysis of test elements |
US6232129B1 (en) * | 1999-02-03 | 2001-05-15 | Peter Wiktor | Piezoelectric pipetting device |
US7073246B2 (en) * | 1999-10-04 | 2006-07-11 | Roche Diagnostics Operations, Inc. | Method of making a biosensor |
US6662439B1 (en) * | 1999-10-04 | 2003-12-16 | Roche Diagnostics Corporation | Laser defined features for patterned laminates and electrodes |
USD435300S (en) * | 1999-12-16 | 2000-12-19 | Roche Diagnostics Corporation | Biosensor |
US6413395B1 (en) * | 1999-12-16 | 2002-07-02 | Roche Diagnostics Corporation | Biosensor apparatus |
US20010036424A1 (en) * | 2000-02-18 | 2001-11-01 | Olympus Optical Co., Ltd. | Liquid pipetting apparatus and micro array manufacturing apparatus |
US20030047011A1 (en) * | 2000-02-25 | 2003-03-13 | Ulrich Diermann | Micro perfusion device comprising a collecting container |
US6557427B2 (en) * | 2000-05-24 | 2003-05-06 | Micronics, Inc. | Capillaries for fluid movement within microfluidic channels |
USD441089S1 (en) * | 2000-06-19 | 2001-04-24 | Roche Diagnostics Corporation | Biosensor |
US6428664B1 (en) * | 2000-06-19 | 2002-08-06 | Roche Diagnostics Corporation | Biosensor |
US7063774B2 (en) * | 2000-07-20 | 2006-06-20 | Roche Diagnostics Operations, Inc. | Recloseable biosensor |
US6488828B1 (en) * | 2000-07-20 | 2002-12-03 | Roche Diagnostics Corporation | Recloseable biosensor |
US6645359B1 (en) * | 2000-10-06 | 2003-11-11 | Roche Diagnostics Corporation | Biosensor |
US6911621B2 (en) * | 2000-11-01 | 2005-06-28 | Roche Diagnostics Corporation | Biosensor |
US6540890B1 (en) * | 2000-11-01 | 2003-04-01 | Roche Diagnostics Corporation | Biosensor |
US6814843B1 (en) * | 2000-11-01 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor |
US6447657B1 (en) * | 2000-12-04 | 2002-09-10 | Roche Diagnostics Corporation | Biosensor |
US20020160520A1 (en) * | 2001-03-16 | 2002-10-31 | Phoenix Bioscience | Silicon nano-collection analytic device |
US6767440B1 (en) * | 2001-04-24 | 2004-07-27 | Roche Diagnostics Corporation | Biosensor |
US7128876B2 (en) * | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
US20040197231A1 (en) * | 2001-07-27 | 2004-10-07 | Koji Katsuki | Analyzing instrument |
US20030028125A1 (en) * | 2001-08-06 | 2003-02-06 | Yuzhakov Vadim V. | Physiological sample collection devices and methods of using the same |
US6814844B2 (en) * | 2001-08-29 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor with code pattern |
US20030070498A1 (en) * | 2001-09-06 | 2003-04-17 | Yasuhiro Ohyama | Automatic sample analyzer and its components |
US6755949B1 (en) * | 2001-10-09 | 2004-06-29 | Roche Diagnostics Corporation | Biosensor |
US6866758B2 (en) * | 2002-03-21 | 2005-03-15 | Roche Diagnostics Corporation | Biosensor |
US20060233671A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US20060233672A1 (en) * | 2003-09-19 | 2006-10-19 | Reed Mark T | High density plate filler |
US20060233673A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US20070014694A1 (en) * | 2003-09-19 | 2007-01-18 | Beard Nigel P | High density plate filler |
US20070003444A1 (en) * | 2003-11-21 | 2007-01-04 | Steven Howell | Laminated device |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110081275A1 (en) * | 2009-10-06 | 2011-04-07 | Institut Fur Mikrotechnik Mainz Gmbh | Microfluidic structure |
US9186638B2 (en) * | 2009-10-06 | 2015-11-17 | Fraunhofer-Gellschaft Zur Förderung Der Angewandten Forschung E.V. | Microfluidic structure |
US20220099668A1 (en) * | 2019-01-11 | 2022-03-31 | Guangzhou Wondfo Biotech Co., Ltd. | Immunochromatographic assay device |
Also Published As
Publication number | Publication date |
---|---|
US7305896B2 (en) | 2007-12-11 |
US20050229722A1 (en) | 2005-10-20 |
JP2007504438A (en) | 2007-03-01 |
WO2005020817A1 (en) | 2005-03-10 |
EP1667581A1 (en) | 2006-06-14 |
AU2004268431A1 (en) | 2005-03-10 |
CA2537091A1 (en) | 2005-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7305896B2 (en) | Capillary fill test device | |
US7238534B1 (en) | Capillary active test element having an intermediate layer situated between the support and the covering | |
KR100555194B1 (en) | Process for production of analytical devices | |
JP4627774B2 (en) | Sampling device for liquid samples | |
US5975153A (en) | Capillary fill test device with improved fluid delivery | |
EP3001173A1 (en) | Capillary fluid flow measurment and capillary flow device therefore | |
JP2001526391A (en) | Analytical test element having a narrowed capillary channel | |
JP4811267B2 (en) | Microchip and analytical device using the same | |
JP7034947B2 (en) | Test system for analyzing body fluid samples | |
JPH09506284A (en) | Measuring device for fluid analysis | |
US20120231488A1 (en) | Fluid sample collection device | |
JP2013530409A (en) | Test strip for body fluid sample detection | |
CN1845704A (en) | Sampling device with capillary action | |
MXPA00005419A (en) | Capillary active test element having an intermediate layer situated between the support and the covering | |
CZ20002021A3 (en) | Analytic testing element with capillary channel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |