US20050209512A1 - Detecting sleep - Google Patents
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- US20050209512A1 US20050209512A1 US10/825,964 US82596404A US2005209512A1 US 20050209512 A1 US20050209512 A1 US 20050209512A1 US 82596404 A US82596404 A US 82596404A US 2005209512 A1 US2005209512 A1 US 2005209512A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4809—Sleep detection, i.e. determining whether a subject is asleep or not
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36078—Inducing or controlling sleep or relaxation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
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- A—HUMAN NECESSITIES
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- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
- A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
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- A—HUMAN NECESSITIES
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- A61M2230/00—Measuring parameters of the user
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- A61M2230/00—Measuring parameters of the user
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- A—HUMAN NECESSITIES
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- A61M2230/00—Measuring parameters of the user
- A61M2230/63—Motion, e.g. physical activity
Abstract
A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep.
Description
- This application claims the benefit of U.S. Provisional Application No. 60/553,771, filed Mar. 16, 2004, which is incorporated herein by reference in its entirety.
- The invention relates to medical devices, and to techniques for determining whether a patient is asleep.
- The ability to determine whether a patient is asleep is useful in a variety of medical contexts. In some situations, the ability to determine whether a patient is asleep is used to diagnose conditions of the patient. For example, the amount of time that patients sleep, the extent of arousals during sleep, and the times of day that patients sleep have been used to diagnose sleep apnea. Such sleep information could also be used to diagnose psychological disorders, such as depression and mania.
- In other situations, a determination as to whether a patient is asleep is used to control delivery of therapy to the patient. For example, neurostimulation or drug therapies can be suspended when the patient is asleep, or the intensity/dosage of the therapies can be reduced when a patient is asleep. As another example, the rate response settings of a cardiac pacemaker may be adjusted to less aggressive settings when the patient is asleep so that the patient's heart will not be paced at an inappropriately high rate during sleep. In these examples, therapy may be suspended or adjusted when the patient is asleep to avoid patient discomfort, or to conserve a battery and/or contents of a fluid reservoir of an implantable medical device when the therapy may be unneeded or ineffective. However, in other cases, a therapy intended to be delivered when the patient is asleep, such as therapy intended to prevent or treat sleep apnea, is delivered based on a determination that the patient is asleep.
- Existing techniques for determining whether a patient is asleep include monitoring the electroencephalogram (EEG) of the patient to identify brain wave activity indicative of sleep. However, EEG monitoring typically requires that an array of electrodes be placed on a patient's scalp and coupled to an external monitoring device, and is most often performed in a clinic setting. Generally, an implantable medical device may only be used to monitor a patient's EEG in the rare cases when it is coupled to electrodes implanted within the brain of the patient. Consequently, EEG monitoring is generally unsuitable as a technique for determining whether a patient is asleep in order to control therapy, or for long-term monitoring of the patient's sleep/wake cycle.
- Existing techniques employed by implantable medical devices to determine whether a patient is asleep include monitoring the patient's respiration rate, respiration rate variability, and activity level. Each of these physiological parameters may be an inaccurate indicator of whether a patient is asleep. For example, from the perspective of these physiological parameters, it may appear that a patient is sleeping when, instead, the patient is merely lying down in a relaxed state. As another example, respiration rate and respiration rate variability, for example, may fail to accurately indicate that the patient is asleep when the patient suffers from a breathing disorder, such as Cheyne-Stokes syndrome.
- In general, the invention is directed to techniques for determining whether a patient is asleep. In some embodiments, the invention is directed to techniques that involve determination of values of one or more sleep metrics that indicate a probability of a patient being asleep based on the current value of one or more physiological parameters of the patient. Use of a plurality of sleep metrics, in particular, may allow for a more accurate determination of whether a patient is asleep.
- A system according to the invention includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. Exemplary physiological parameters include activity level, posture, heart rate, respiration rate, respiratory volume, blood pressure, blood oxygen saturation, partial pressure of oxygen within blood, partial pressure of oxygen within cerebrospinal fluid, muscular activity, core temperature, arterial blood flow, and galvanic skin response.
- The processor monitors the physiological parameters based on the signals generated by the sensors, and determines whether the patient is asleep based on values for the physiological parameters. The value for a physiological parameter may be a current, mean or median value for the parameter. In some embodiments, the processor may additionally or alternatively determine whether the patient is asleep based on the variability of one or more of the physiological parameters.
- In some embodiments, the processor determines a value of a sleep metric that indicates a probability of the patient being asleep based on a physiological parameter. In particular, the processor may apply a function or look-up table to the current value and/or variability of the physiological parameter to determine the sleep metric value. The processor may compare the sleep metric value to a threshold value to determine whether the patient is asleep. In some embodiments, the processor may compare the sleep metric value to each of a plurality of thresholds to determine the current sleep state of the patient, e.g., rapid eye movement (REM), or one of the nonrapid eye movement (NREM) states (S1, S2, S3, S4). Because they provide the most “refreshing” type of sleep, the ability to determine whether the patient is in one of the S3 and S4 sleep states may be, in some embodiments, particularly useful.
- Further, in some embodiments the processor may determine a sleep metric value for each of a plurality of physiological parameters. In other words, the processor may apply a function or look-up table for each parameter to the current value for that parameter in order to determine the sleep metric value for that parameter. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value for comparison to the threshold values. In some embodiments, a weighting factor may be applied to one or more of the sleep metric values. One or more of functions, look-up tables, thresholds and weighting factors may be selected or adjusted by a user in order to select or adjust the sensitivity and specificity of the system in determining whether the patient is asleep.
- In some embodiments, the processor is included as part of a medical device, such as an implantable medical device. The sensors may also be included within the medical device, coupled to the medical device by one or more leads, or in wireless communication with the medical device. The medical device may control delivery of therapy to the patient based on the determination as to whether the patient is asleep, or may store information indicating when the patient is asleep for later retrieval and analysis by user. In some embodiments, the medical device may instead use the one or more sleep metric values to control delivery of therapy, or may store one or more sleep metric values. In some embodiments, information relating to the patient's sleep patterns may be used to diagnose sleep or psychological disorder, or may be used to evaluate the effectiveness of a therapy delivered to the patient.
- In one embodiment, the invention is directed to a method in which a plurality of physiological parameters of a patient are monitored and a value of a sleep metric that indicates a probability of the patient being asleep is determined based on the physiological parameters.
- In another embodiment, the invention is directed to a medical system that comprises at least one sensor and a processor. The sensor generates a signal as a function of at least one physiological parameter of a patient. The processor receives the signal from the sensor, monitors a plurality of physiological parameters of the patient, and determines a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
- In another embodiment, the invention is directed to a medical system that comprises means for monitoring a plurality of physiological parameters of a patient and means for determining a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
- In another embodiment, the invention is directed to a method in which a physiological parameter of a patient is monitored via an implantable medical device, and whether the patient is asleep is determined based on the physiological parameter. The physiological parameter comprises one of heart rate, blood pressure, blood oxygen saturation, muscular activity and core temperature.
- In another embodiment, the invention is directed to a medical system that comprises a sensor and an implantable medical device. The sensor generates a signal as a function of a physiological parameter of a patient. The physiological parameter comprises one of heart rate, blood pressure, blood oxygen saturation, muscular activity, core temperature, arterial blood flow, and galvanic skin response. The implantable medical device includes a processor that monitors the physiological parameter based on the signal and determines whether the patient is asleep based on the physiological parameter.
- In another embodiment, the invention is directed to a computer-readable medium comprising program instructions. The instructions cause a programmable processor to monitor a plurality of physiological parameters of a patient, and determine a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
- The invention may be capable of providing one or more advantages. For example, the invention provides techniques for determining a sleep state of a patient that may be implemented in an implantable medical device. Further, the techniques provided by the invention may include analysis of a variety of physiological parameters not previously used in determining whether a patient is asleep. Where it is desired to detect sleep via an implantable medical device, the ability to determine whether a patient is sleeping based on these physiological parameters may increase the number of implantable medical device types in which the invention may be implemented, i.e., the invention may be implemented in a variety of types of implantable medical devices which include or may be easily modified to include sensors capable of generating a signal based on such physiological parameters.
- Monitoring a plurality of physiological parameters according to some embodiments, rather than a single parameter, may allow for a more accurate determination of whether a patient is asleep than is available via existing implantable medical devices. Use of sleep metrics that indicate a probability of the patient being asleep for each of a plurality of physiological parameters may further increase the reliability with which an implantable medical device may determine whether a patient is asleep. In particular, rather than a binary sleep or awake determination for each of a plurality of parameters, sleep metric values for each of a plurality of parameters may be combined to yield an overall sleep metric value that may be compared to a threshold to determine whether the patient is asleep. In other words, failure of any one physiological parameter to accurately indicate whether a patient is sleeping may be less likely to prevent the implantable medical device from accurately indicating whether the patient is sleeping when considered in combination with other physiological parameters.
- The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims.
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FIG. 1 is a conceptual diagram illustrating an example system including an implantable medical device that determines whether a patient is asleep according to the invention. -
FIG. 2 is a block diagram further illustrating the system ofFIG. 1 . -
FIG. 3 is a block diagram illustrating a memory within an implantable medical device of the system ofFIG. 1 . -
FIG. 4 is a flowchart illustrating an example technique for determining whether a patient is asleep. -
FIG. 1 is a conceptual diagram illustrating anexample system 10 that includes an implantable medical device (IMD) 14 that determines whether apatient 12 is asleep according to the invention. In the illustrated example system,IMD 14 takes the form of an implantable neurostimulator that delivers neurostimulation therapy in the form of electrical pulses topatient 12. However, the invention is not limited to implementation via an implantable neurostimulator, or even to implementation via an IMD. - For example, in some embodiments of the invention, an implantable pump or implantable cardiac pacemaker may determine whether a patient is asleep. In other embodiments, a programming device may determine when
patient 12 is asleep based on information collected by a medical device. In other words, any implantable or external device may determine whether a patient is asleep according to the invention. - In the illustrated example,
IMD 14 delivers neurostimulation therapy topatient 12 vialeads FIG. 1 , be implanted proximate to thespinal cord 18 ofpatient 12, andIMD 14 may deliver spinal cord stimulation (SCS) therapy topatient 12 in order to, for example, reduce pain experienced bypatient 12. However, the invention is not limited to the configuration of leads 16 shown inFIG. 1 or the delivery of SCS therapy. For example, one or more leads 16 may extend fromMD 14 to the brain (not shown) ofpatient 12, andIMD 14 may deliver deep brain stimulation (DBS) therapy topatient 12 to, for example, treat tremor or epilepsy. As further examples, one or more leads 16 may be implanted proximate to the pelvic nerves (not shown) or stomach (not shown), andIMD 14 may deliver neurostimulation therapy to treat incontinence or gastroparesis. -
IMD 14 delivers therapy according to a set of therapy parameters that define the delivered therapy. In embodiments whereIMD 14 delivers neurostimulation therapy in the form of electrical pulses, the parameters for each of the parameter sets may include voltage or current pulse amplitudes, pulse widths, pulse rates, and the like. Further, each of leads 16 includes electrodes (not shown inFIG. 1 ), and the parameters may include information identifying which electrodes have been selected for delivery of pulses, and the polarities of the selected electrodes. -
System 10 also includes aclinician programmer 20. A clinician (not shown) may useclinician programmer 20 to program neurostimulation therapy forpatient 12.Clinician programmer 20 may, as shown inFIG. 1 , be a handheld computing device.Clinician programmer 20 includes adisplay 22, such as a LCD or LED display, to display information to a user.Clinician programmer 20 may also include akeypad 24, which may be used by a user to interact withclinician programmer 20. In some embodiments,display 22 may be a touch screen display, and a user may interact withclinician programmer 20 viadisplay 22. A user may also interact withclinician programmer 20 using peripheral pointing devices, such as a stylus, mouse, or the like.Keypad 24 may take the form of an alphanumeric keypad or a reduced set of keys associated with particular functions. -
System 10 also includes apatient programmer 26, which also may, as shown inFIG. 1 , be a handheld computing device.Patient 12 may usepatient programmer 26 to control the delivery of neurostimulation therapy byIMD 14.Patient programmer 26 may also include adisplay 28 and akeypad 30, to allowpatient 12 to interact withpatient programmer 26. In some embodiments,display 26 may be a touch screen display, andpatient 12 may interact withpatient programmer 26 viadisplay 28.Patient 12 may also interact withpatient programmer 26 using peripheral pointing devices, such as a stylus or mouse. -
IMD 14,clinician programmer 20 andpatient programmer 26 may, as shown inFIG. 1 , communicate via wireless communication.Clinician programmer 20 andpatient programmer 26 may, for example, communicate via wireless communication withIMD 14 using RF telemetry techniques known in the art.Clinician programmer 20 andpatient programmer 26 may communicate with each other using any of a variety of local wireless communication techniques, such as RF communication according to the 802.11 or Bluetooth specification sets, infrared communication according to the IRDA specification set, or other standard or proprietary telemetry protocols. -
Clinician programmer 20 andpatient programmer 26 need not communicate wirelessly, however. For example,programmers clinician programmer 20 may communicate with one or both ofIMD 14 andpatient programmer 26 via remote telemetry techniques known in the art, communicating via a local area network (LAN), wide area network (WAN), public switched telephone network (PSTN), or cellular telephone network, for example. - As mentioned above,
IMD 14 is capable of determining whetherpatient 12 is asleep. Specifically, as will be described in greater detail below,IMD 14 monitors a plurality of physiological parameters ofpatient 12 that may discernibly change whenpatient 12 is asleep, and determines whetherpatient 12 is asleep based on values of the physiological parameters. The value for a physiological parameter may be a current, mean or median value for the parameter. In some embodiments,IMD 14 may additionally or alternatively determine whetherpatient 12 is asleep based on the variability of one or more of the physiological parameters.IMD 14 includes, is coupled to, or is in wireless communication with one or more sensors, and monitors the physiological parameters via the sensors. - Exemplary physiological parameters that may be monitored by
IMD 14 include activity level, posture, heart rate, respiration rate, respiratory volume, blood pressure, blood oxygen saturation, partial pressure of oxygen within blood, partial pressure of oxygen within cerebrospinal fluid, muscular activity, core temperature, and arterial blood flow. In some external medical device embodiments of the invention, galvanic skin response may additionally or alternatively be monitored. Some of the parameters, such as activity level, heart rate, respiration rate, respiratory volume, blood pressure, arterial oxygen saturation and partial pressure, partial pressure of oxygen in the cerebrospinal fluid, muscular activity, core temperature, arterial blood flow, and galvanic skin response may be at low values whenpatient 12 is asleep. Further, the variability of at least some of these parameters, such as heart rate and respiration rate, may be at a low value when the patient is asleep. Information regarding the posture ofpatient 12 will most likely indicate thatpatient 12 is lying down whenpatient 12 is asleep. - In some embodiments,
IMD 14 determines a value of one or more sleep metrics based on a value of one or more physiological parameters ofpatient 12. A sleep metric value may be a numeric value that indicates the probability thatpatient 12 is asleep. In some embodiments, the sleep metric value may be a probability value, e.g., a number within the range from 0 to 1. - In particular, the
IMD 14 may apply a function or look-up table to the current, mean or median value, and/or the variability of the physiological parameter to determine a value of the sleep metric.IMD 14 may compare the sleep metric value to a threshold value to determine whether the patient is asleep. In some embodiments, theIMD 14 may compare the sleep metric value to each of a plurality of thresholds to determine the current sleep state of the patient, e.g., rapid eye movement (REM), S1, S2, S3, or S4. Because they provide the most “refreshing” type of sleep, the ability to determine whether the patient is in one of the S3 and S4 sleep states may be, in some embodiments, particularly useful. - Further, in some
embodiments IMD 14 may determine a sleep metric value for each of a plurality of physiological parameters. In other words,IMD 14 may apply a function or look-up table for each parameter to a value for that parameter in order to determine the sleep metric value for that parameter.IMD 14 may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value for comparison to the threshold values. In some embodiments,IMD 14 may apply a weighting factor to one or more of the sleep metric values prior to combination. One or more of functions, look-up tables, thresholds and weighting factors may be selected or adjusted by a user, such as a clinician viaprogrammer 20 orpatient 12 viaprogrammer 26, in order to select or adjust the sensitivity and specificity ofIMD 14 in determining whetherpatient 12 is asleep. - Monitoring a plurality of physiological parameters according to some embodiments, rather than a single parameter, may allow
IMD 14 to determine whetherpatient 12 is asleep with more accuracy than existing implantable medical devices. Use of sleep metric values that indicate a probability of the patient being asleep for each of a plurality of physiological parameters may further increase the accuracy with whichIMD 14 may determine whetherpatient 12 is asleep. In particular, rather than a binary sleep or awake determination for each of a plurality of parameters, sleep metric values for each of a plurality of parameters may be combined to yield an overall sleep metric value that may be compared to a threshold to determine whetherpatient 12 is asleep. In other words, failure of any one physiological parameter to accurately indicate whether a patient is sleeping may be less likely to preventIMD 14 from accurately indicating whetherpatient 12 is sleeping when considered in combination with other physiological parameters. -
IMD 14 may control delivery of therapy topatient 12 based on the determination as to whetherpatient 12 is asleep. For example,IMD 14 may suspend delivery of neurostimulation or reduce the intensity of delivered neurostimulation whenpatient 14 is determined to be asleep. In other embodiments,IMD 14 may suspend or reduce intensity of drug delivery, or may reduce the aggressiveness of rate response for cardiac pacing whenpatient 12 is determined to be asleep. In still other embodiments,IMD 14 may initiate delivery of a therapy, such as a therapy to treat or prevent sleep apnea, whenpatient 12 is determined to be asleep. - In some embodiments,
IMD 14 stores information indicating whenpatient 12 is asleep, which may be retrieved for analysis by a clinician viaprogrammer 20, for example. The clinician may use the sleep information to diagnose conditions ofpatient 12, such as sleep apnea or psychological disorders. Information relating to the sleep patterns ofpatient 12 may in other situations indicate the effectiveness of a delivered therapy and/or the need for increased therapy. Some ailments ofpatient 12, such as chronic pain, tremor, gastrointestinal disorders, incontinence, congestive heart failure, and sleep apnea may disturb or hinder the sleep orpatient 12, or, in some cases, inadequate or disturbed sleep may increase the symptoms of these ailments. -
IMD 14 may collect information relating to the sleep patterns ofpatient 12, which may be retrieved by a clinician viaprogrammer 20 and used to evaluate the effectiveness of a therapy delivered topatient 12 for such an ailment, or to indicate the need for an additional therapy to improve the sleep pattern ofpatient 12. In some cases,IMD 14 may evaluate such collected sleep information and automatically adjust a therapy for such a condition based on the evaluation. Further information regarding evaluation of a therapy based on sleep information collected by an IMD may be found in a commonly-assigned and copending U.S. patent application by Ken Heruth and Keith Miesel, entitled “COLLECTING SLEEP QUALITY INFORMATION VIA A MEDICAL DEVICE,” which is filed on Apr. 15, 2004 and assigned attorney docket number 1023-250US01. Further information regarding automatic control of a therapy based on sleep information collected by an IMD may be found in a commonly-assigned and copending U.S. patent application by Ken Heruth and Keith Miesel, entitled “CONTROLLING THERAPY BASED ON SLEEP QUALITY,” which is filed on Apr. 15, 2004 and assigned attorney docket number 1023-363US01. The entire content of both of these applications is incorporated herein by reference. -
FIG. 2 is a block diagram further illustratingsystem 10. In particular,FIG. 2 illustrates an example configuration ofIMD 14 and leads 16A and 16B.FIG. 2 also illustratessensors patient 12.IMD 14 monitors the signals to determine whetherpatient 12 is asleep. -
IMD 14 may deliver neurostimulation therapy viaelectrodes 42A-D oflead 16A andelectrodes 42E-H oflead 16B (collectively “electrodes 42”). Electrodes 42 may be ring electrodes. The configuration, type and number of electrodes 42 illustrated inFIG. 2 are merely exemplary. For example, leads 16A and 16B may each include eight electrodes 42, and the electrodes 42 need not be arranged linearly on each of leads 16A and 16B. - Electrodes 42 are electrically coupled to a
therapy delivery module 44 vialeads Therapy delivery module 44 may, for example, include a pulse generator coupled to a power source such as a battery.Therapy delivery module 44 may deliver electrical pulses topatient 12 via at least some of electrodes 42 under the control of aprocessor 46, which controlstherapy delivery module 44 to deliver neurostimulation therapy according to a set of therapy parameters, which may be one of a plurality of therapy parameter sets stored inmemory 48. However, the invention is not limited to implantable neurostimulator embodiments or even to IMDs that deliver electrical stimulation. For example, in some embodiments atherapy delivery module 44 of an IMD may include a pump, circuitry to control the pump, and a reservoir to store a therapeutic agent for delivery via the pump. -
Processor 46 may include a microprocessor, a controller, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field-programmable gate array (FPGA), discrete logic circuitry, or the like.Memory 48 may include any volatile, non-volatile, magnetic, optical, or electrical media, such as a random access memory (RAM), read-only memory (ROM), non-volatile RAM (NVRAM), electrically-erasable programmable ROM (EEPROM), flash memory, and the like. In some embodiments,memory 48 stores program instructions that, when executed byprocessor 46,cause IMD 14 andprocessor 46 to perform the functions attributed to them herein. - Each of sensors 40 generates a signal as a function of one or more physiological parameters of
patient 12. Although shown as including two sensors 40,system 10 may include any number of sensors. As illustrated inFIG. 2 , sensors 40 may be included as part ofIMD 14, or coupled toIMD 14 via leads 16. Sensors 40 may be coupled toIMD 14 via therapy leads 16A and 16B, or via other leads 16, such aslead 16C depicted inFIG. 2 . In some embodiments, a sensor located outside ofIMD 14 may be in wireless communication withprocessor 46. - As discussed above, exemplary physiological parameters of
patient 12 that may be monitored byIMD 14 to determine values of one or more sleep metrics include activity level, posture, heart rate, respiration rate, respiratory volume, blood pressure, blood oxygen saturation, partial pressure of oxygen within blood, partial pressure of oxygen within cerebrospinal fluid, muscular activity, core temperature, and arterial blood flow. Further, as discussed above, in some external medical device embodiments of the invention galvanic skin response may additionally or alternatively be monitored. The detected values of these physiological parameters ofpatient 12 may discernibly change when patient 12 falls asleep or wakes up. In particular, these physiological parameters may be at low values whenpatient 12 is asleep. Further, the variability of at least some of these parameters, such as heart rate and respiration rate, may be at a low value when the patient is asleep. Sensors 40 may be of any type known in the art capable of generating a signal as a function of one or more of these parameters. - For example, sensors 40 may include electrodes located on leads or integrated as part of the housing of
IMD 14 that generate an electrogram signal as a function of electrical activity of the heart ofpatient 12, andprocessor 46 may monitor the heart rate ofpatient 12 based on the electrogram signal. In other embodiments, a sensor may include an acoustic sensor withinIMD 14, a pressure or flow sensor within the bloodstream or cerebrospinal fluid ofpatient 12, or a temperature sensor located within the bloodstream ofpatient 12. The signals generated by such sensors may vary as a function of contraction of the heart ofpatient 12, and can be used byIMD 14 to monitor the heart rate ofpatient 12. - Sensors 40 may include one or more accelerometers, gyros, mercury switches, or bonded piezoelectric crystals that generate a signal as a function of patient activity, e.g., body motion, footfalls or other impact events, and the like. Sensors 40 may also include a plurality of accelerometers, gyros, or magnetometers oriented orthogonally that generate signals that indicate the posture of
patient 12. In addition to being oriented orthogonally with respect to each other, each of sensors 40 used to detect the posture ofpatient 12 may be generally aligned with an axis of the body ofpatient 12. When accelerometers, for example, are aligned in this manner, the magnitude and polarity of DC components of the signals generate by the accelerometers indicate the orientation of the patient relative to the Earth's gravity, e.g., the posture ofpatient 12. Further information regarding use of orthogonally aligned accelerometers to determine patient posture may be found in a commonly-assigned U.S. Pat. No. 5,593,431, which issued to Todd J. Sheldon. - In some embodiments, sensors 40 may include an electrode pair, including one electrode integrated with the housing of
IMD 14 and one of electrodes 42, that generates a signal as a function of the thoracic impedance ofpatient 12, which varies as a function of respiration bypatient 12. In other embodiments, sensors 40 may include a strain gauge, bonded piezoelectric element, or pressure sensor within the blood or cerebrospinal fluid that generates a signal that varies based on patient respiration. An electrogram generated by electrodes as discussed above may also be modulated by patient respiration, and may be used as an indirect representation of respiration rate. - Sensors 40 may include electrodes that generate an electromyogram (EMG) signal as a function of muscle electrical activity, or may include any of a variety of known temperature sensors to generate a signal as a function of a core temperature of
patient 12. Such electrodes and temperature sensors may be incorporated within the housing ofIMD 14, or coupled toIMD 14 via leads. Sensors 40 may also include a pressure sensor within, or in contact with, a blood vessel. The pressure sensor may generate a signal as a function of the a blood pressure ofpatient 12, and may, for example, comprise a Chronicle Hemodynamic Monitor™ commercially available from Medtronic, Inc. of Minneapolis, Minn. - Sensors 40 may also include optical pulse oximetry sensors or Clark dissolved oxygen sensors located within, as part of a housing of, or outside of
IMD 14, which generate signals as a function of blood oxygen saturation and blood oxygen partial pressure respectively. In some embodiments,system 10 may include a catheter with a distal portion located within the cerebrospinal fluid ofpatient 12, and the distal end may include a Clark sensor to generate a signal as a function of the partial pressure of oxygen within the cerebrospinal fluid. Embodiments in which an IMD comprises an implantable pump, for example, may include a catheter with a distal portion located in the cerebrospinal fluid. - In some embodiments, sensors 40 may include one or more intraluminal, extraluminal, or external flow sensors positioned to generate a signal as a function of arterial blood flow. A flow sensor may be, for example, an electromagnetic, thermal convection, ultrasonic-Doppler, or laser-Doppler flow sensor. Further, in some external medical device embodiments of the invention, sensors 40 may include one or more electrodes positioned on the skin of
patient 12 to generate a signal as a function of galvanic skin response. -
Processor 46 monitors the physiological parameters based on the signals generated by the one or more sensors 40, and determines whetherpatient 12 is asleep based on current values for the physiological parameters. In some embodiments,processor 46 may determine mean or median value for the parameter based on values of the signal over time, and determines whetherpatient 12 is asleep based on the mean or median value. In other embodiments,processor 46 may additionally or alternatively determine a variability of one or more of the parameters based on the values of the parameter over time, and may determine whetherpatient 12 is asleep based on the one or more variability values.IMD 14 may include circuitry (not shown) that conditions the signals generate by sensors 40 such that they may be analyzed byprocessor 46. For example,IMD 14 may include one or more analog to digital converters to convert analog signals generate by sensors 40 into digital signals usable byprocessor 46, as well as suitable filter and amplifier circuitry. - In some embodiments,
processor 46 determines a value of a sleep metric that indicates a probability of the patient being asleep based on a physiological parameter. In particular,processor 46 may apply a function or look-up table to the current value, mean or median value, and/or variability of the physiological parameter to determine the sleep metric value. For example, the values of one or more physiological parameters serve as indices to the lookup table to yield a corresponding output value, which serves as the sleep metric value.Processor 46 may compare the sleep metric value to a threshold value to determine whetherpatient 12 is asleep. In some embodiments,processor 46 may compare the sleep metric value to each of a plurality of thresholds to determine the current sleep state ofpatient 12, e.g., rapid eye movement (REM), S1, S2, S3, or S4. - Further, in some
embodiments processor 46 determines a sleep metric value for each of a plurality of monitored physiological parameters. In other words,processor 46 may apply a function or look-up table for each parameter to the current value for that parameter in order to determine the sleep metric value for that individual parameter.Processor 46 may then average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value, and may determine whetherpatient 12 is asleep based on the overall sleep metric value. In some embodiments,processor 46 may apply a weighting factor to one or more of the sleep metric values prior to combination. - As shown in
FIG. 3 ,memory 48 may includeparameter information 60 recorded byprocessor 46, e.g., parameter values, or mean or median parameter values.Memory 48 may also store sleep metric functions 62 or look-up tables (not shown) thatprocessor 46 may retrieve for application to physiological parameter values or variability values, andthreshold values 64 thatprocessor 46 may use to determine whetherpatient 12 is asleep and, in some embodiments, the sleep state ofpatient 12.Memory 48 may also store weighting factors 66 used byprocessor 46 when combining sleep metric values to determine an overall sleep metric value.Processor 46 may storesleep information 68 withinmemory 48, such as recorded sleep metric values and information indicating whenpatient 12 was asleep. - As shown in
FIG. 2 ,IMD 14 also includes atelemetry circuit 50 that allowsprocessor 46 to communicate withclinician programmer 20 andpatient programmer 26. For example, usingclinician programmer 20, a clinician may directprocessor 46 to retrievesleep information 68 frommemory 48 and transmit the information viatelemetry circuit 50 toprogrammer 20 for analysis. Further, the clinician may select or adjust the one or more offunctions 62, look-up tables,thresholds 64 andweighting factors 66 in order to select or adjust the sensitivity and specificity ofprocessor 46 determining whether the patient is asleep. -
FIG. 4 is a flowchart illustrating an example technique for determining whether a patient is asleep that may be employed byIMD 14. According to the example technique,IMD 14 monitors a plurality of physiological parameters of patient 12 (70). More particularly,processor 46 receives signals from one or more sensors 40, and monitors the physiological parameters based on the signals. -
Processor 46 applies arespective function 62 to current values, mean or median values, and/or variability values for each of physiological parameters to determine a sleep metric value for each of the parameters (72).Processor 46 then combines the various sleep metric values to determine a current overall sleep metric value (74). Forexample processor 46 may applyweighting factors 66 to one or more of the parameter specific sleep metric values, and then average the parameter specific sleep metric values in light of the weighting factors 66. -
Processor 46 compares the current overall sleep metric value to a threshold value 64 (76), and determines whetherpatient 12 is asleep or awake, e.g., whether the sleep state ofpatient 12 has changed, based on the comparison (78). For example,processor 46 may determine thatpatient 12 is asleep if the current overall sleep metric value exceeds thethreshold value 64. If the sleep state ofpatient 12 has changed,processor 46 may initiate, suspend or adjust a therapy delivered topatient 12 byIMD 14, orprocessor 46 may store an indication of the time and the change within memory 48 (80). - Various embodiments of the invention have been described. However, one skilled in the art will appreciated that various modifications may be made to the described embodiments without departing from the scope of the invention. For example, although described herein in the context of an implantable neurostimulator, the invention may be embodied in any implantable or external medical device.
- As another example, although described in the context of determining whether a patient is asleep, e.g., whether the patient's current sleep state is asleep or awake, the invention may, as described above, be used to determine what level of sleep a patient is currently experiencing, e.g., which of sleep states REM, S1, S2, S3, and S4 the patient is currently in. A medical device may record transitions between these states and between sleep and wakefulness, or may control therapy based on transitions between these states and between sleep and wakefulness. Further, in some embodiments, a medical device may, without making a sleep determination, simply record one or more determined sleep metric values for later analysis, or may control delivery of therapy based on the sleep metric values.
- Further, the invention may be embodied in a programming device, such as
programmers patient 12 is asleep according to the invention instead of, or in addition to an implantable or external medical device. For example, a medical device may record values for one or more of the physiological parameters discussed herein, and may provide the physiological parameter values to the programming device in real time or when interrogated by the programming device. The programming device may apply the techniques described herein with reference toIMD 14 to determine whenpatient 12 is asleep, and may control delivery of therapy based on the determination, or present information relating to the patient's sleep patterns to a user to enable diagnosis or therapy evaluation. - The invention may also be embodied as a computer-readable medium, such as
memory 48, that includes instructions to cause a processor, such asprocessor 46, to perform any of the methods described herein. These and other embodiments are within the scope of the following claims.
Claims (68)
1. A method comprising:
monitoring a plurality of physiological parameters of a patient; and
determining a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
2. The method of claim 1 , wherein the physiological parameters comprise at least one of activity level, posture, heart rate, respiration rate, respiratory volume, and core temperature.
3. The method of claim 1 , wherein the physiological parameters comprise at least one of blood pressure, blood oxygen saturation, partial pressure of oxygen within blood, partial pressure of oxygen within cerebrospinal fluid, muscular activity, core temperature, arterial blood flow, and galvanic skin response.
4. The method of claim 1 , further comprising determining a variability of at least one of the physiological parameters, wherein determining a value of the sleep metric comprises determining the value of the sleep metric based on the variability.
5. The method of claim 1 , further comprising determining at least one of a mean value and a median value for at least one of the physiological parameters, wherein determining a value of a sleep metric comprises determining the sleep metric based on the at least one of the mean value and the median value.
6. The method of claim 1 , wherein determining a value of a sleep metric comprises determining a value for each of a plurality of sleep metrics, each of the values determined based on a respective one of the physiological parameters.
7. The method of claim 6 , wherein determining a value of a sleep metric comprises determining a value of an overall sleep metric based on the plurality of sleep metric values.
8. The method of claim 7 , wherein determining a value of an overall sleep metric comprises averaging the values of the plurality of sleep metrics.
9. The method of claim 7 , wherein determining a value of an overall sleep metric comprises applying a weighting factor to a value of at least one of the plurality of sleep metrics.
10. The method of claim 1 , further comprising:
comparing the value of the sleep metric to a threshold value; and
determining whether the patient is asleep based on the comparison.
11. The method of claim 10 , further comprising:
comparing the value of the sleep metric to a plurality of thresholds; and
determining a sleep state of the patient based on the comparison.
12. The method of claim 11 , wherein determining a sleep state of the patient comprises determining whether the patient is in one of a rapid eye movement (REM) sleep state and a nonrapid eye movement (NREM) sleep state.
13. The method of claim 10 , wherein the threshold value is selected by a user.
14. The method of claim 10 , further comprising controlling delivery of a therapy to the patient based on the determination of whether the patient is asleep.
15. The method of claim 10 , further comprising storing information indicating when the patient is asleep for retrieval by a user.
16. The method of claim 15 , further comprising evaluating the effectiveness of a therapy delivered to the patient based on the information indicating whether the patient is asleep.
17. The method of claim 16 , wherein the therapy comprises at least one of a neurostimulation and a drug therapy.
18. The method of claim 16 , wherein the therapy is a pain therapy.
19. A medical system comprising:
a plurality of sensors, each of the sensors generating a signal as a function of at least one physiological parameter of a patient; and
a processor that monitors a plurality of physiological parameters of the patient based on the signals output by the sensors, and determines a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
20. The system of claim 19 , wherein the physiological parameters comprise at least one of activity level, posture, heart rate, respiration rate, respiratory volume, and core temperature.
21. The system of claim 19 , wherein physiological parameters comprise at least one of blood pressure, blood oxygen saturation, partial pressure of oxygen within blood, partial pressure of oxygen within cerebrospinal fluid, muscular activity, arterial blood flow, and galvanic skin response.
22. The system of claim 19 , wherein the processor determines a variability of at least one of the physiological parameters, and determines the sleep metric based on the variability.
23. The system of claim 19 , wherein the processor determines at least one of a mean value and a median value of at least one of the physiological parameters, and determines the sleep metric based on the at least one of the mean value and the median value.
24. The system of claim 19 , wherein the processor determines a value of each of a plurality of sleep metrics, each of the plurality of values determined based on a respective one of the physiological parameters.
25. The system of claim 24 , wherein the processor determines a value of an overall sleep metric based the values of the plurality of sleep metrics.
26. The system of claim 25 , wherein the processor determines the value of the overall sleep metric by averaging the values of the plurality of sleep metrics.
27. The system of claim 26 , wherein the processor applies a weighting factor to at least one of values of the plurality of sleep metrics.
28. The system of claim 19 , further comprising a memory to store a threshold value, wherein the processor compares the value of the sleep metric to a threshold value and determines whether the patient is asleep based on the comparison.
29. The system of claim 28 , wherein the memory stores a plurality of threshold values, and the processor compares the value of the sleep metric to each of the threshold values and determines a sleep state of the patient based on the comparison.
30. The system of claim 29 , wherein the processor determines whether the patient is in one of a rapid eye movement (REM) sleep state and a nonrapid eye movement (NREM) sleep state.
31. The system of claim 28 , further comprising a user interface, wherein a user selects the threshold via the user interface.
32. The system of claim 28 , wherein the processor controls delivery of a therapy to the patient based on the determination of whether the patient is asleep.
33. The system of claim 28 , wherein the processor stores information indicating when the patient is asleep within the memory for retrieval by a user.
34. The system of claim 19 , further comprising an implantable medical device that includes the processor.
35. The system of claim 34 , wherein the implantable medical device includes the sensor.
36. The system of claim 34 , wherein the implantable medical device is coupled to the sensor via a lead.
37. The system of claim 34 , wherein the implantable medical device is wirelessly coupled to the sensor.
38. The system of claim 34 , wherein the implantable medical device comprises at least one of an implantable neurostimulator and an implantable pump.
39. A system comprising:
means for monitoring a plurality of physiological parameters of a patient; and
means for determining a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
40. The system of claim 39 , further comprising means for generating at least one signal as a function of the physiological parameters, wherein the means for monitoring comprises means for monitoring the physiological parameters based on the signal.
41. The system of claim 39 , wherein the means for determining a sleep metric comprises means for determining a value for each of a plurality of sleep metrics, each of the plurality of values determined based on a respective one of the physiological parameters.
42. The system of claim 41 , wherein the means for determining a value of a sleep metric comprises means for determining a value of an overall sleep metric based the values of the plurality of sleep metrics.
43. The system of claim 41 , further comprising means for comparing the value of the sleep metric to a threshold value and determining whether the patient is asleep based on the comparison.
44. The system of claim 43 , further comprising:
means for delivering a therapy to the patient; and
means for controlling delivery of a therapy to the patient by the therapy delivery means based on the determination of whether the patient is asleep.
45. The system of claim 43 , further comprising means for storing information indicating when the patient is asleep for retrieval by a user.
46. A method comprising:
monitoring a physiological parameter of a patient via an implantable medical device, wherein the physiological parameter comprises one of blood pressure, blood oxygen saturation, muscular activity, core temperature, arterial blood flow, and galvanic skin response; and
determining whether a patient is asleep based on the physiological parameter.
47. The method of claim 46 , wherein monitoring a physiological parameter comprises monitoring a plurality of physiological parameters, and wherein determining whether a patient is asleep comprises determining whether the patient is asleep based on the plurality of physiological parameters.
48. The method of claim 47 , wherein determining whether a patient is asleep comprises:
determining a value of a sleep metric that indicates a probability of the patient being asleep based on the plurality of physiological parameters;
comparing the value of the sleep metric to a threshold value; and
determining whether the patient is asleep based on the comparison.
49. The method of claim 48 , wherein determining a sleep metric comprises:
determining a value of a sleep metric for each of the plurality of monitored physiological parameters; and
determining a value of an overall sleep metric based on the values of the plurality of sleep metrics, and
wherein determining whether the patient is asleep comprises determining whether the patient is asleep based on comparison of the value of the overall sleep metric to the threshold.
50. The method of claim 46 , further comprising controlling delivery of a therapy to the patient based on the determination of whether the patient is asleep.
51. The method of claim 46 , further comprising storing information indicating when the patient is asleep for retrieval by a user.
52. The method of claim 51 , further comprising evaluating the effectiveness of a therapy delivered to the patient based on the information indicating whether the patient is asleep.
53. A medical system comprising:
a sensor to generate a signal as a function of a physiological parameter of a patient, wherein the physiological parameter comprises one of blood pressure, blood oxygen saturation, muscular activity, core temperature, arterial blood flow, and galvanic skin response; and
an implantable medical device that includes a processor to monitor the physiological parameter based on the signal and determine whether a patient is asleep based on the physiological parameter.
54. The system of claim 53 ,
further comprising a plurality of sensors that generate a signal as a function of a physiological parameter of a patient,
wherein the processor monitors a plurality of physiological parameters based on the signals and determines whether the patient is asleep based on the plurality of physiological parameters.
55. The system of claim 54 ,
wherein the implantable medical device further comprises a memory to store a threshold value, and
wherein the processor determines a value of a sleep metric that indicates a sleep state of the patient based on the plurality of physiological parameters, compares the value of the sleep metric to a threshold value, and determines whether the patient is asleep based on the comparison.
56. The system of claim 55 , wherein the processor determines a value of a sleep metric for each of the plurality of monitored physiological parameters, determines a value of an overall sleep metric based on the values of the plurality of sleep metrics, and determines whether the patient is asleep based on comparison of the value of the overall sleep metric to the threshold.
57. The system of claim 53 , wherein the processor controls delivery of a therapy to the patient based on the determination of whether the patient is asleep.
58. The system of claim 53 ,
wherein the implantable medical device further comprises a memory, and
wherein the processor stores information indicating when the patient is asleep within the memory for retrieval by a user.
59. The system of claim 53 , wherein the implantable medical device includes the sensor.
60. The system of claim 53 , wherein the implantable medical device is coupled to the sensor via a lead
61. The system of claim 53 , wherein the implantable medical device is wirelessly coupled to the sensor.
62. The system of claim 53 , wherein the implantable medical device comprises at least one of an implantable neurostimulator and an implantable pump.
63. A computer-readable medium comprising instructions that cause a programmable processor to:
monitor a plurality of physiological parameters of a patient; and
determine a value of a sleep metric that indicates a probability of the patient being asleep based on the physiological parameters.
64. The medium of claim 63 , further comprising instructions that cause the processor to determine a variability of at least one of the physiological parameters, wherein the instructions that cause the processor to determine a value of the sleep metric comprise instructions that cause the processor to determine the value of the sleep metric based on the variability.
65. The medium of claim 63 , further comprising instructions that cause the processor to:
determine a value for each of a plurality of sleep metrics, each of the values determined based on a respective one of the physiological parameters; and
determine a value of an overall sleep metric based on the plurality of sleep metric values.
66. The medium of claim 63 , further comprising instructions that cause the processor to:
compare the value of the sleep metric to a threshold value; and
determine whether the patient is asleep based on the comparison.
67. The method of claim 66 , further comprising instructions that cause the processor to:
compare the value of the sleep metric to a plurality of thresholds; and
determine a sleep state of the patient based on the comparison.
68. The medium of claim 67 , wherein the instructions that cause the processor to determine a sleep state of the patient comprise instructions that cause the processor to determine whether the patient is in one of a rapid eye movement (REM) sleep state and a nonrapid eye movement (NREM) sleep state.
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US20100274106A1 (en) | 2010-10-28 |
ATE464836T1 (en) | 2010-05-15 |
DE602005020758D1 (en) | 2010-06-02 |
US7775993B2 (en) | 2010-08-17 |
US20050222522A1 (en) | 2005-10-06 |
EP1732436B1 (en) | 2010-04-21 |
WO2005089641A1 (en) | 2005-09-29 |
EP1732436A1 (en) | 2006-12-20 |
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