US20050145559A1 - Filter assembly - Google Patents
Filter assembly Download PDFInfo
- Publication number
- US20050145559A1 US20050145559A1 US10/694,404 US69440403A US2005145559A1 US 20050145559 A1 US20050145559 A1 US 20050145559A1 US 69440403 A US69440403 A US 69440403A US 2005145559 A1 US2005145559 A1 US 2005145559A1
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- US
- United States
- Prior art keywords
- housing
- filter medium
- filter
- end cap
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/44—Mechanical actuating means
- F16K31/52—Mechanical actuating means with crank, eccentric, or cam
- F16K31/528—Mechanical actuating means with crank, eccentric, or cam with pin and slot
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D27/00—Cartridge filters of the throw-away type
- B01D27/005—Making filter elements not provided for elsewhere
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D27/00—Cartridge filters of the throw-away type
- B01D27/08—Construction of the casing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D36/00—Filter circuits or combinations of filters with other separating devices
- B01D36/001—Filters in combination with devices for the removal of gas, air purge systems
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D36/00—Filter circuits or combinations of filters with other separating devices
- B01D36/003—Filters in combination with devices for the removal of liquids
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L37/00—Couplings of the quick-acting type
- F16L37/24—Couplings of the quick-acting type in which the connection is made by inserting one member axially into the other and rotating it to a limited extent, e.g. with bayonet action
- F16L37/244—Couplings of the quick-acting type in which the connection is made by inserting one member axially into the other and rotating it to a limited extent, e.g. with bayonet action the coupling being co-axial with the pipe
- F16L37/248—Bayonet-type couplings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2201/00—Details relating to filtering apparatus
- B01D2201/08—Regeneration of the filter
- B01D2201/088—Arrangements for killing microorganisms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2201/00—Details relating to filtering apparatus
- B01D2201/16—Valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2201/00—Details relating to filtering apparatus
- B01D2201/40—Special measures for connecting different parts of the filter
- B01D2201/4015—Bayonet connecting means
Definitions
- the invention relates to filter assemblies.
- a known form of filter assembly comprises a housing providing an inlet port and an outlet port with a filter element being held in the housing and comprising a filter medium having a central passage extending between first and second ends of the filter medium.
- the first end of the filter medium is connected to an end cap to close the passage and the second end of the filter medium is in fluid communication with a port of the housing.
- the filter element must be capable of being integrity tested.
- integrity can be tested by the Water Bubble Point Test or the Diffusive Forward Flow Test.
- the filter element is placed in a water bath with both the first and second ends of the passage closed and air is pumped into the passage at a pressure which is increased until the first bubble is observed on the exterior of the filter medium. If the structure of the filter medium has integrity over its whole volume, this first bubble will appear at a predetermined pressure. If a bubble or bubbles appear at a lower pressure, it is an indication that the structure of the filter medium is not uniform over the whole volume of the filter medium. This can indicate the incidence of passages through the filter medium which might allow the passage through the medium in use of unfiltered or only partly filtered fluid.
- the filter medium is wetted with water and surplus water is removed. Air is applied to one side of the medium at a specified pressure and the diffusive air flow rate is measured. This diffusive air flow rate has been found to be related to the removal rating of the medium. A greater than expected flow rate can indicate lack of integrity of the medium.
- connection to a water-wettable filter medium of an end cap can change the characteristics of the medium so that integrity testing is no longer possible.
- the connection can produce hydrophobic zones in the medium which do not wet out in the integrity test and thus plainly affect the performance of the medium in the integrity test.
- the materials of the filter medium and the end cap are usually chosen so that connection of the medium and the end cap does not affect the characteristics of the medium in a manner that would affect the medium's performance in an integrity test.
- the material of the end cap is also important for hydrophobic filter media. Some hydrophobic filter media are easily damaged by heat. These media are attached to the end cap by heating the end cap to soften the end cap and inserting the first end of the medium into the end cap while the end cap is softened. It is therefore important to choose a material for the end cap that softens at a relatively low temperature such that the connection can be carried out without damaging the media.
- filter assemblies that have medical, biomedical and pharmaceutical uses that they can be sterilized to allow for repeated use.
- in situ steam sterilization instead of fluid to be filtered passing to the filter assembly, high pressure and high temperature steam are passed through the filter assembly.
- the steam pressure may be several bars and the temperature 140° C.
- steam autoclaving the filter assembly is removed from associated equipment and transferred to an autoclave where it is steam sterilized. The filter assembly is then removed from the autoclave, transferred aseptically and replaced in the equipment.
- a typical filter assembly might need sterilizing 100 times in its lifetime.
- the second end of the filter medium is usually connected to the housing by heating the housing material and inserting the second end of the filter medium into the housing material.
- the housing of an appropriate material that produces the required join For hydrophobic media that are relatively easily damaged by heat it is necessary for the plastics material of the housing to have a relatively low softening temperature.
- Such plastics materials are not able to withstand the pressures and temperatures of in situ steam sterilization. Accordingly, such filter assemblies must be sterilized by autoclaving. This requires the filter assembly to be removed from service, autoclaved and then transferred aseptically back into service.
- the known alternative is to house the filter element in a metal housing.
- the metal will withstand the temperatures and pressures of in situ steam sterilization but metal housings are typically much bulkier than plastics housings and are more expensive to produce and require cleaning before re-use.
- a filter assembly comprising a plastics housing providing an inlet port and an outlet port, the material of the housing being such that the assembly can be sterilized by subjecting the interior of the housing to steam under pressure while the exterior of the housing is at atmospheric pressure without damaging the housing, a filter element held in the housing and comprising a filter medium of water wettable material having a central passage extending between first and second ends of the filter medium, the first end of the filter medium being embedded in a first end cap of a plastics material to close said passage and the second end of the filter medium being embedded in a second end cap of a plastics material, said second end cap providing a fluid connection between said passage and one of said ports, the first and second end caps forming respective water-wettable joints with the filter medium.
- a filter assembly comprising a housing having an inlet and an outlet and a filter element that is integrity testable by the Diffusive Forward Flow Test or the Water Bubble Point Test, that is held in the housing and that comprise's a filter medium having a central passage extending between first and second ends of the filter medium, the housing being formed from a plastics material that is steam sterilizable.
- a valve for a filter assembly comprising an annular sleeve'surrounding a passage of generally circular cross-section, movement of said sleeve in one sense opening said valve and movement of said sleeve in a sense opposite said one sense closing said valve.
- a valve comprising a part defining a cylindrical passage and a valve member movable between a first position in which the member sits in and seals against the circumference of the passage to close the valve and a second position in which the member is located out of the passage to open the valve.
- FIG. 1 is an exploded view of a filter assembly showing first and second parts of a filter housing; a filter element within the housing and valves connected to inlet and drainage ports of the housing,
- FIG. 2 is a cross-section on the axis of the housing of FIG. 1 , showing one valve in an open position and a second valve in a closed position,
- FIG. 3 is detail B of FIG. 2 showing the open valve to a larger scale
- FIG. 4 is detail C of FIG. 2 showing the closed valve to a larger scale.
- the filter assembly comprises a housing indicated generally, at 10 , a filter element 11 encapsulated in the housing 10 and two valves 12 carried by the housing 10 .
- the housing 10 comprises a first housing part 13 and a second housing part 14 . Both parts are made, for example moulded, from a polysulphone material.
- the first housing part 13 includes an end wall 15 provided with an inlet port 16 for the medium to be filtered, and a circular cross-section side wall 17 extending downwardly from the end wall 15 and terminating at a circular edge 18 .
- An outwardly facing annular rebate 19 is formed in the side wall 17 adjacent the edge.
- An air vent port 20 is formed at the junction between the end wall 15 and the side wall 17 and extends in a direction generally radially relative to the axis 21 (see FIG. 2 ) of the housing 10 .
- the inner surface 60 of the air vent port 20 defines a passage having a smaller diameter portion 22 closer to the side wall 17 and a larger diameter portion 23 further from the side wall 17 and terminating at the end of the air vent port 20 .
- Five ribs 61 extend into the larger diameter portion 23 from the inner surface 60 .
- the ribs 61 are spaced equi-angularly around the surface 60 .
- Each rib 61 has an edge 62 that is continuous and in line with the inner surface 60 at the small diameter portion of the passage.
- the air vent port 20 has an exterior surface 24 provided with an annular groove 25 adjacent the end of the port 20 which carries an O-ring seal 26 .
- this surface 24 has two pins 27 projecting radially from the surface at respective positions on the surface spaced from the end of the port 20 . The function of the seal 26 and the pins 27 is described below.
- the second housing part 14 includes a second end wall 28 provided with a disc-shaped stand 29 .
- the second end wall 28 has its end remote from the stand of generally annular shape coaxial with the axis 21 of the housing 10 . This portion of the second end wall 28 is provided with an inwardly facing rebate 30 .
- the'second end wall 28 has an outlet port 31 in the form of a generally circular cross-section passage co-axial with the axis 21 of the housing 10 and extending through the second end wall 28 and the stand 29 .
- the end of the outlet port 31 within the housing 10 forms an annular flange 32 .
- a drainage port 33 is provided in the second end wall 28 and extends radially from the second end wall 28 relative to the axis 21 of the housing 10 .
- the drainage port 33 is constructed similarly to the air vent port 20 (parts common to the two ports 20 , 33 are given the same reference numerals and will not be described in detail).
- the filter element 11 comprises a filter medium 34 , a first end cap 35 , a second end cap 36 and a cage 37 .
- the filter medium may be of any convenient material and any convenient shape that provides a central passage for the flow of fluid to be filtered.
- the filter medium 34 may be annular.
- the material may be pleated or unpleated. Examples of suitable filter media are those sold by Pall Corporation under the trade marks ULTIPOR, FLUORODYNE, SUPOR and EMFLON.
- the filter medium 34 has a first end and a second end with the passage extending between the ends.
- the first end cap 35 is disc-shaped and is formed from a plastics material.
- the first end cap 35 is preferably connected to the first end of the filter medium 34 by heating the end cap 35 to soften the end cap 35 and then inserting the filter medium into the softened end cap material to form a join.
- the material of the first end cap 35 is chosen so that, when the filter medium 34 is connected to the first end cap 35 , the characteristics of the medium 34 are not materially changed.
- the filter medium 34 is of a water-wettable material
- the material of the first end cap is chosen to that a water wettable joint is formed between the filter medium 34 and the first end cap 35 .
- the end cap material will depend on the material of the filter medium 34 .
- the filter medium 34 is a FLUORODYNE or SUPOR medium
- the end cap 35 may be composed of polypropylene.
- the first end cap 35 may be composed of a polyester or nylon material.
- An integrity test involves the filter element being placed in a bath of water (with the ends of the passage closed) and air is then supplied to the passage at increasing pressure. The bath is then observed to determine at what pressure the first bubble appears on the exterior of the filter medium. If the porous structure of the filter medium is integral over the whole area of the filter medium, then the first bubble will appear at a relatively high pressure. If, however, the porous structure is not integral over the whole area of the filter medium 34 , then the first bubble will appear at a relatively lower pressure.
- first end cap 35 and the filter medium 34 are not water-wettable, it creates a hydrophobic zone through which air passes readily since the porous structure is not wetted out by water. Although this does not normally affect filtration during use of the assembly, it is not possible to test the integrity as described above. The formation of hydrophobic zones similarly prevents the medium being tested by the Diffusive Forward Flow Test described above.
- the filter medium 34 is hydrophobic, it is important to ensure that the first end cap 35 is composed of a material that can be softened at a temperature that is sufficiently low so that the integrity of the medium 35 is not damaged by the insertion process.
- the first end cap 35 may be, composed of polypropylene.
- the filter medium 35 is composed of PTFE, which is relatively resistant to heat, it is also preferable to use polypropylene end caps.
- the second end cap 36 comprises a flat annular portion 38 with a central aperture.
- a projecting tube 39 surrounds the aperture and extends away from the filter medium 34 in a direction normal to the plane of the flat annular portion 38 .
- the tube 39 is provided with two annular seals 40 on its exterior surface 41 .
- Four flanges 42 project radially outwardly of the flat annular portion 38 and are equi-angularly spaced around this portion 38 .
- the outer diameter of the tube 39 is generally equal to the interior diameter of the outlet port 31 .
- the material of the second end cap is chosen based on the same considerations affecting the choice of the material of the first end cap.
- the material of the second end cap 36 will normally, but not necessarily, be the same as the material of the first end cap 35 .
- the filter medium 34 is connected to the second end cap 36 by heating the second end cap 36 and then inserting the filter medium 34 into the softened material.
- the cage 37 which is of known type, surrounds the exterior surface of the filter medium 34 between the first and second end caps 35 , 36 .
- the filter element 11 is mounted in the housing in the following way. First, the tube 39 on the second end cap 36 is inserted into the outlet port 31 in the second end wall 28 . The seals 40 prevent leakage between these parts. When fully inserted, the flange 32 of the outlet port 31 bears against the under surface of the flat annular portion 38 of the second end cap 36 . This holds the filter element 11 in the second end wall 28 coaxial with the housing axis 21 . In addition, it connects the interior passage of the filter medium 34 with the outlet port 31 via the tube 39 .
- the first housing part 13 is then placed over the filter element 11 with the edge 18 fitting within the second end wall 28 and the rebate 19 adjacent this edge mating with the rebate 30 in the second end wall 28 .
- the first and second housing parts 13 , 14 are then welded together around the rebates 19 , 30 .
- the edge 18 of the side wall 17 bears against the flanges 42 .
- the effect of this is to clamp the filter element 11 between this edge 18 and the end of the flange 32 surrounding the outlet port 31 and contacting the second end cap 36 . In this way, the filter element 11 is held firmly in position encapsulated in the housing 10 .
- valves 12 control flow through the air vent port 20 and the drainage port 33 .
- the valves 12 are identical and so only one of them will be described.
- the valve 12 comprises an elongated valve member 43 which is generally circular in cross-section.
- the valve member 43 has a blind end 44 within the associated port.
- the blind end 44 carries an O-ring 45 in a groove provided on an exterior surface.
- the remainder of the valve member 43 has an axial passage 46 leading to a connector 47 for connection to a hose or pipe.
- the connector 47 has an annular triangular-section rib 63 and in FIG. 4 the connector 47 has a succession of axially spaced ribs 64 .
- At least one radial passage 48 connects the end of the axial passage 46 adjacent the blind end 44 with the exterior surface of the valve member 43 .
- a sleeve 49 is arranged coaxially with the axis of the valve member 43 and is spaced from the valve member 43 by an annular radially extending flange 50 .
- the sleeve 49 is a sliding fit over the exterior surface 24 of the associated port 20 , 31 .
- the sleeve is provided with two helical slots 51 (seen best in FIG. 1 ) extending around a portion of the sleeve 49 . Each pin 27 is received in a respective one of the slots 51 .
- the sleeve 49 can thus be rotated relative to the associated port 20 , 33 with such rotation being controlled by the engagement of the pin 27 in the slot 51 to cause the sleeve 49 also to move axially relative to the associated port 20 , 33 .
- This rotation can take place in both senses.
- FIGS. 3 and 4 The effect of this rotation is best seen in FIGS. 3 and 4 .
- the blind end 44 of the valve member 43 lies in the larger diameter portion 23 of the associated port 20 , 33 .
- the valve member 43 , and the associated O-ring 45 do not obstruct the port and so allow flow into the port, through the radial passage 48 and along the axial passage 46 .
- Reverse flow is, of course, also possible.
- Leakage around the sleeve 49 is prevented by the O-ring seal 26 on the exterior surface 24 of the port 20 , 33 .
- the O-ring 45 is kept pressed into the groove on the outer surface of the blind end by the, ribs 61 —the edges 62 bearing against the O-ring 45 .
- the associated port 20 , 33 can be opening or closed. It will also be appreciated that the pin 27 and slot 51 mechanism prevents the valve 12 being disengaged completely from the associated port 20 , 33 .
- the valves 12 are preferably made from a polysulphone material.
- the housing parts 13 , 14 and the valves 12 may also be made from any other suitable plastics material capable of withstanding in-line sterilization.
- in-line sterilization involves passing steam under pressure through the housing.
- the exterior of the housing is kept at atmospheric pressure and so there is a pressure differential across the housing.
- the minimum temperature and pressure of steam commonly used for sterilization is generally about 121° C. at about 1 bar above atmospheric pressure, although in some circumstances, in particular if exposure to the steam is prolonged, sterilization may be achievable at lower temperatures and pressures.
- the housing is preferably resistant to such harsher conditions.
- plastics other than polysulphone that are suitable are PEEK, PEK, polyphenyleneoxide, polyphenylenesulphide, polyethersulphone polyalkoxysulphone and polyarylsulphone.
- the filter assembly described above with reference to the drawings is mounted in a line containing a fluid to be filtered.
- a fluid to be filtered This may be, for example, a medical, biomedical or pharmaceutical fluid.
- a tube leading from a source of fluid to be filtered is connected to the inlet 16 .
- the outlet port 31 is connected to a receiver of filtered fluid.
- the drainage port 33 is connected to a tube leading to a receiver for drained fluid.
- the valve 12 of the air vent port 20 is opened and the valve 12 of the drainage port 33 is closed. Fluid to be filtered is then fed through the inlet 16 to fill the housing 10 .
- the air vent port 20 is then shut.
- the fluid passes through the filter medium 34 where it is filtered and the filtered fluid enters the passage before passing through the tube 39 and the outlet port 31 .
- the inlet 16 When the filter assembly is to be sterilized, the inlet 16 is disconnected from the supply of fluid to be filtered and the outlet port 31 is disconnected from the receiver of filtered fluid.
- the drainage port valve 12 is open to drain excess fluid from the housing 10 .
- the inlet 16 is then connected to a supply of steam under pressure and the outlet port 31 is connected to a drain.
- the valves 12 are left slightly open. Steam at the pressure of several bars and a temperature of about 140° C. is then fed through the housing to steam sterilize the filter material 34 and the other components.
- the housing is 10 , since it is made of polysulphone (or another suitable plastics material), is able to withstand the temperature and pressure of the steam.
- the valves 12 because they are made of polysulphone (or another suitable plastics material), they will withstand the in-line steam sterilization without damage.
- water can be drained by fully opening the drainage port valve 12 and the filter assembly reconnected for filtering fluid.
- these parts can be made in different materials to provide the water wettability necessary for the filter medium 34 and the resistance to in-line steam sterilization necessary for the housing 10 .
- the valves 12 need not be as described above. Any suitable valves could be used.
- the plastics material of the housing 10 need not be polysulphone, it could be any material that is capable of withstanding in-line steam sterilization.
- the filter element 11 need not be clamped in the housing 10 as described, it could be held in any suitable way.
- the cage 37 need not be as described, any suitable cage could be provided.
- the filter medium 34 may be provided with upstream and/or downstream drainage layers.
Abstract
A filter assembly comprises a plastics housing and a filter element held in the housing. The housing can be sterilized by subjecting the interior of the housing to steam under pressure while the exterior of the housing is at atmospheric pressure. The filter element comprises a water wettable filter medium. The ends of the filter medium are embedded in first and second plastics end caps. The first and second end caps form respective water-wettable joints with the filter medium and the characteristics of the filter medium are not materially changed.
Description
- The invention relates to filter assemblies.
- A known form of filter assembly comprises a housing providing an inlet port and an outlet port with a filter element being held in the housing and comprising a filter medium having a central passage extending between first and second ends of the filter medium. The first end of the filter medium is connected to an end cap to close the passage and the second end of the filter medium is in fluid communication with a port of the housing.
- In this way, fluid passing to the housing flows through the filter medium in a path including the inlet port, the outlet port and the passage. Such filters are used extensively for medical, biomedical and pharmaceutical purposes.
- It is a requirement of such filter assemblies that the filter element must be capable of being integrity tested. For water-wettable filter media integrity can be tested by the Water Bubble Point Test or the Diffusive Forward Flow Test. In the Water Bubble Point Test, the filter element is placed in a water bath with both the first and second ends of the passage closed and air is pumped into the passage at a pressure which is increased until the first bubble is observed on the exterior of the filter medium. If the structure of the filter medium has integrity over its whole volume, this first bubble will appear at a predetermined pressure. If a bubble or bubbles appear at a lower pressure, it is an indication that the structure of the filter medium is not uniform over the whole volume of the filter medium. This can indicate the incidence of passages through the filter medium which might allow the passage through the medium in use of unfiltered or only partly filtered fluid.
- In the Diffusive Forward Flow Test, the filter medium is wetted with water and surplus water is removed. Air is applied to one side of the medium at a specified pressure and the diffusive air flow rate is measured. This diffusive air flow rate has been found to be related to the removal rating of the medium. A greater than expected flow rate can indicate lack of integrity of the medium.
- However, the connection to a water-wettable filter medium of an end cap can change the characteristics of the medium so that integrity testing is no longer possible. For example, the connection can produce hydrophobic zones in the medium which do not wet out in the integrity test and thus plainly affect the performance of the medium in the integrity test.
- For this reason, the materials of the filter medium and the end cap are usually chosen so that connection of the medium and the end cap does not affect the characteristics of the medium in a manner that would affect the medium's performance in an integrity test.
- The material of the end cap is also important for hydrophobic filter media. Some hydrophobic filter media are easily damaged by heat. These media are attached to the end cap by heating the end cap to soften the end cap and inserting the first end of the medium into the end cap while the end cap is softened. It is therefore important to choose a material for the end cap that softens at a relatively low temperature such that the connection can be carried out without damaging the media.
- However, it is also a requirement for such filter assemblies that have medical, biomedical and pharmaceutical uses that they can be sterilized to allow for repeated use. There are two principal forms of sterilization; in situ steam sterilization and steam autoclaving. In in situ steam sterilization, instead of fluid to be filtered passing to the filter assembly, high pressure and high temperature steam are passed through the filter assembly. For example, the steam pressure may be several bars and the temperature 140° C. In steam autoclaving, the filter assembly is removed from associated equipment and transferred to an autoclave where it is steam sterilized. The filter assembly is then removed from the autoclave, transferred aseptically and replaced in the equipment. A typical filter assembly might need sterilizing 100 times in its lifetime.
- Where the housing of such a filter assembly is made of a plastics material, the second end of the filter medium is usually connected to the housing by heating the housing material and inserting the second end of the filter medium into the housing material. For water-wettable media, in order to produce a water wettable joint for integrity testing purposes, it is thus necessary to have the housing of an appropriate material that produces the required join. For hydrophobic media that are relatively easily damaged by heat it is necessary for the plastics material of the housing to have a relatively low softening temperature. Such plastics materials are not able to withstand the pressures and temperatures of in situ steam sterilization. Accordingly, such filter assemblies must be sterilized by autoclaving. This requires the filter assembly to be removed from service, autoclaved and then transferred aseptically back into service.
- The known alternative is to house the filter element in a metal housing. The metal will withstand the temperatures and pressures of in situ steam sterilization but metal housings are typically much bulkier than plastics housings and are more expensive to produce and require cleaning before re-use.
- According to a first aspect of the invention, there is provided a filter assembly comprising a plastics housing providing an inlet port and an outlet port, the material of the housing being such that the assembly can be sterilized by subjecting the interior of the housing to steam under pressure while the exterior of the housing is at atmospheric pressure without damaging the housing, a filter element held in the housing and comprising a filter medium of water wettable material having a central passage extending between first and second ends of the filter medium, the first end of the filter medium being embedded in a first end cap of a plastics material to close said passage and the second end of the filter medium being embedded in a second end cap of a plastics material, said second end cap providing a fluid connection between said passage and one of said ports, the first and second end caps forming respective water-wettable joints with the filter medium.
- By end capping both ends of the filter medium, water wettable joints can be produced and a different material used for the housing that is steam sterilizable in situ.
- According to a second aspect of the invention, there is provided a filter assembly comprising a housing having an inlet and an outlet and a filter element that is integrity testable by the Diffusive Forward Flow Test or the Water Bubble Point Test, that is held in the housing and that comprise's a filter medium having a central passage extending between first and second ends of the filter medium, the housing being formed from a plastics material that is steam sterilizable.
- It is also a problem with such filter assemblies in providing valves for the inlet port and the outlet port. Such valves need to be capable of steam sterilization, and many are not.
- According to a third aspect of the invention, there is provided a valve for a filter assembly comprising an annular sleeve'surrounding a passage of generally circular cross-section, movement of said sleeve in one sense opening said valve and movement of said sleeve in a sense opposite said one sense closing said valve.
- According to a fourth aspect of the invention there is provided a valve comprising a part defining a cylindrical passage and a valve member movable between a first position in which the member sits in and seals against the circumference of the passage to close the valve and a second position in which the member is located out of the passage to open the valve.
- The following is a more detailed description of an embodiment of the invention, by way of example, reference being made to the accompanying drawings in which:
-
FIG. 1 is an exploded view of a filter assembly showing first and second parts of a filter housing; a filter element within the housing and valves connected to inlet and drainage ports of the housing, -
FIG. 2 is a cross-section on the axis of the housing ofFIG. 1 , showing one valve in an open position and a second valve in a closed position, -
FIG. 3 is detail B ofFIG. 2 showing the open valve to a larger scale, and -
FIG. 4 is detail C ofFIG. 2 showing the closed valve to a larger scale. - Referring to the drawings, and particularly
FIG. 1 , the filter assembly comprises a housing indicated generally, at 10, afilter element 11 encapsulated in thehousing 10 and twovalves 12 carried by thehousing 10. - The
housing 10 comprises afirst housing part 13 and asecond housing part 14. Both parts are made, for example moulded, from a polysulphone material. Thefirst housing part 13 includes anend wall 15 provided with aninlet port 16 for the medium to be filtered, and a circularcross-section side wall 17 extending downwardly from theend wall 15 and terminating at acircular edge 18. An outwardly facingannular rebate 19 is formed in theside wall 17 adjacent the edge. - An
air vent port 20 is formed at the junction between theend wall 15 and theside wall 17 and extends in a direction generally radially relative to the axis 21 (seeFIG. 2 ) of thehousing 10. Theinner surface 60 of theair vent port 20 defines a passage having asmaller diameter portion 22 closer to theside wall 17 and alarger diameter portion 23 further from theside wall 17 and terminating at the end of theair vent port 20. Fiveribs 61 extend into thelarger diameter portion 23 from theinner surface 60. Theribs 61 are spaced equi-angularly around thesurface 60. Eachrib 61 has anedge 62 that is continuous and in line with theinner surface 60 at the small diameter portion of the passage. - The
air vent port 20 has anexterior surface 24 provided with anannular groove 25 adjacent the end of theport 20 which carries an O-ring seal 26. In addition, thissurface 24 has twopins 27 projecting radially from the surface at respective positions on the surface spaced from the end of theport 20. The function of theseal 26 and thepins 27 is described below. - The
second housing part 14 includes asecond end wall 28 provided with a disc-shaped stand 29. Thesecond end wall 28 has its end remote from the stand of generally annular shape coaxial with theaxis 21 of thehousing 10. This portion of thesecond end wall 28 is provided with an inwardly facingrebate 30. - As best seen in
FIG. 2 , the'secondend wall 28 has anoutlet port 31 in the form of a generally circular cross-section passage co-axial with theaxis 21 of thehousing 10 and extending through thesecond end wall 28 and thestand 29. - The end of the
outlet port 31 within thehousing 10 forms anannular flange 32. - A
drainage port 33 is provided in thesecond end wall 28 and extends radially from thesecond end wall 28 relative to theaxis 21 of thehousing 10. Thedrainage port 33 is constructed similarly to the air vent port 20 (parts common to the twoports - The
filter element 11 comprises afilter medium 34, afirst end cap 35, asecond end cap 36 and acage 37. The filter medium may be of any convenient material and any convenient shape that provides a central passage for the flow of fluid to be filtered. For example, thefilter medium 34 may be annular. The material may be pleated or unpleated. Examples of suitable filter media are those sold by Pall Corporation under the trade marks ULTIPOR, FLUORODYNE, SUPOR and EMFLON. - The
filter medium 34 has a first end and a second end with the passage extending between the ends. Thefirst end cap 35 is disc-shaped and is formed from a plastics material. Thefirst end cap 35 is preferably connected to the first end of thefilter medium 34 by heating theend cap 35 to soften theend cap 35 and then inserting the filter medium into the softened end cap material to form a join. - The material of the
first end cap 35 is chosen so that, when thefilter medium 34 is connected to thefirst end cap 35, the characteristics of the medium 34 are not materially changed. In particular, when thefilter medium 34 is of a water-wettable material, the material of the first end cap is chosen to that a water wettable joint is formed between thefilter medium 34 and thefirst end cap 35. In this case, the end cap material will depend on the material of thefilter medium 34. For example, when thefilter medium 34 is a FLUORODYNE or SUPOR medium, theend cap 35 may be composed of polypropylene. When thefilter medium 34 is composed of a nylon material thefirst end cap 35 may be composed of a polyester or nylon material. - It is important to obtain a water-wettable joint between water-wettable filter media and the
first end cap 35 in order to allow the filter element to be integrity tested. An integrity test involves the filter element being placed in a bath of water (with the ends of the passage closed) and air is then supplied to the passage at increasing pressure. The bath is then observed to determine at what pressure the first bubble appears on the exterior of the filter medium. If the porous structure of the filter medium is integral over the whole area of the filter medium, then the first bubble will appear at a relatively high pressure. If, however, the porous structure is not integral over the whole area of thefilter medium 34, then the first bubble will appear at a relatively lower pressure. If the junction between thefirst end cap 35 and thefilter medium 34 is not water-wettable, it creates a hydrophobic zone through which air passes readily since the porous structure is not wetted out by water. Although this does not normally affect filtration during use of the assembly, it is not possible to test the integrity as described above. The formation of hydrophobic zones similarly prevents the medium being tested by the Diffusive Forward Flow Test described above. - Where the
filter medium 34 is hydrophobic, it is important to ensure that thefirst end cap 35 is composed of a material that can be softened at a temperature that is sufficiently low so that the integrity of the medium 35 is not damaged by the insertion process. For example, when thefilter medium 34 is composed of, PVDF (such as an EMFLON 2 medium) thefirst end cap 35 may be, composed of polypropylene. Where thefilter medium 35 is composed of PTFE, which is relatively resistant to heat, it is also preferable to use polypropylene end caps. - The
second end cap 36 comprises a flatannular portion 38 with a central aperture. A projectingtube 39 surrounds the aperture and extends away from thefilter medium 34 in a direction normal to the plane of the flatannular portion 38. Thetube 39 is provided with twoannular seals 40 on itsexterior surface 41. Fourflanges 42 project radially outwardly of the flatannular portion 38 and are equi-angularly spaced around thisportion 38. - The outer diameter of the
tube 39 is generally equal to the interior diameter of theoutlet port 31. - For any
filter medium 34, the material of the second end cap is chosen based on the same considerations affecting the choice of the material of the first end cap. The material of thesecond end cap 36 will normally, but not necessarily, be the same as the material of thefirst end cap 35. Thefilter medium 34 is connected to thesecond end cap 36 by heating thesecond end cap 36 and then inserting thefilter medium 34 into the softened material. Thecage 37, which is of known type, surrounds the exterior surface of thefilter medium 34 between the first and second end caps 35, 36. - The
filter element 11 is mounted in the housing in the following way. First, thetube 39 on thesecond end cap 36 is inserted into theoutlet port 31 in thesecond end wall 28. Theseals 40 prevent leakage between these parts. When fully inserted, theflange 32 of theoutlet port 31 bears against the under surface of the flatannular portion 38 of thesecond end cap 36. This holds thefilter element 11 in thesecond end wall 28 coaxial with thehousing axis 21. In addition, it connects the interior passage of thefilter medium 34 with theoutlet port 31 via thetube 39. - The
first housing part 13 is then placed over thefilter element 11 with theedge 18 fitting within thesecond end wall 28 and therebate 19 adjacent this edge mating with therebate 30 in thesecond end wall 28. The first andsecond housing parts rebates - When so positioned, the
edge 18 of theside wall 17 bears against theflanges 42. The effect of this is to clamp thefilter element 11 between thisedge 18 and the end of theflange 32 surrounding theoutlet port 31 and contacting thesecond end cap 36. In this way, thefilter element 11 is held firmly in position encapsulated in thehousing 10. - Referring next to
FIGS. 3 and 4 in particular, thevalves 12 control flow through theair vent port 20 and thedrainage port 33. Thevalves 12 are identical and so only one of them will be described. - The
valve 12 comprises anelongated valve member 43 which is generally circular in cross-section. Thevalve member 43 has ablind end 44 within the associated port. Theblind end 44 carries an O-ring 45 in a groove provided on an exterior surface. The remainder of thevalve member 43 has anaxial passage 46 leading to aconnector 47 for connection to a hose or pipe. InFIG. 3 theconnector 47 has an annular triangular-section rib 63 and inFIG. 4 theconnector 47 has a succession of axially spacedribs 64. At least oneradial passage 48 connects the end of theaxial passage 46 adjacent theblind end 44 with the exterior surface of thevalve member 43. - A
sleeve 49 is arranged coaxially with the axis of thevalve member 43 and is spaced from thevalve member 43 by an annularradially extending flange 50. Thesleeve 49 is a sliding fit over theexterior surface 24 of the associatedport FIG. 1 ) extending around a portion of thesleeve 49. Eachpin 27 is received in a respective one of theslots 51. - The
sleeve 49 can thus be rotated relative to the associatedport pin 27 in theslot 51 to cause thesleeve 49 also to move axially relative to the associatedport - The effect of this rotation is best seen in
FIGS. 3 and 4 . At one limit of rotation in one sense, as seen inFIG. 3 , theblind end 44 of thevalve member 43 lies in thelarger diameter portion 23 of the associatedport valve member 43, and the associated O-ring 45, do not obstruct the port and so allow flow into the port, through theradial passage 48 and along theaxial passage 46. Reverse flow is, of course, also possible. Leakage around thesleeve 49 is prevented by the O-ring seal 26 on theexterior surface 24 of theport ring 45 is kept pressed into the groove on the outer surface of the blind end by the,ribs 61—theedges 62 bearing against the O-ring 45. - Rotation of the
sleeve 49 in the opposite sense moves theblind end 44 into the smaller diameter portion. The O-ring 45 is guided into the smaller diameter portion by theedges 62. Maximum rotation in the opposite sense disposes the valve member as shown inFIG. 4 . In this disposition, theblind end 44 lies within thesmaller diameter portion 22 of the associatedport ring 45 seals against theinner surface 60 of theport port valve member 43 can undergo differential expansion during heating without causing damage to the valve as theblind end 44 simply moves axially with thesmall portion 22. - Thus, by twisting the
sleeve 49 is one sense or the other, the associatedport pin 27 andslot 51 mechanism prevents thevalve 12 being disengaged completely from the associatedport - The
valves 12 are preferably made from a polysulphone material. - The
housing parts valves 12 may also be made from any other suitable plastics material capable of withstanding in-line sterilization. As stated above, in-line sterilization involves passing steam under pressure through the housing. The exterior of the housing is kept at atmospheric pressure and so there is a pressure differential across the housing. The minimum temperature and pressure of steam commonly used for sterilization is generally about 121° C. at about 1 bar above atmospheric pressure, although in some circumstances, in particular if exposure to the steam is prolonged, sterilization may be achievable at lower temperatures and pressures. However, it is often desirable to sterilize the assembly in-line under harsher conditions, for example using steam at about 142° C and about 2.83 bar above atmospheric pressure. The housing is preferably resistant to such harsher conditions. Examples of plastics other than polysulphone that are suitable are PEEK, PEK, polyphenyleneoxide, polyphenylenesulphide, polyethersulphone polyalkoxysulphone and polyarylsulphone. - In use, the filter assembly described above with reference to the drawings is mounted in a line containing a fluid to be filtered. This may be, for example, a medical, biomedical or pharmaceutical fluid. A tube leading from a source of fluid to be filtered is connected to the
inlet 16. Theoutlet port 31 is connected to a receiver of filtered fluid. Thedrainage port 33 is connected to a tube leading to a receiver for drained fluid. Thevalve 12 of theair vent port 20 is opened and thevalve 12 of thedrainage port 33 is closed. Fluid to be filtered is then fed through theinlet 16 to fill thehousing 10. Theair vent port 20 is then shut. The fluid passes through thefilter medium 34 where it is filtered and the filtered fluid enters the passage before passing through thetube 39 and theoutlet port 31. - When the filter assembly is to be sterilized, the
inlet 16 is disconnected from the supply of fluid to be filtered and theoutlet port 31 is disconnected from the receiver of filtered fluid. Thedrainage port valve 12 is open to drain excess fluid from thehousing 10. Theinlet 16 is then connected to a supply of steam under pressure and theoutlet port 31 is connected to a drain. Thevalves 12 are left slightly open. Steam at the pressure of several bars and a temperature of about 140° C. is then fed through the housing to steam sterilize thefilter material 34 and the other components. The housing is 10, since it is made of polysulphone (or another suitable plastics material), is able to withstand the temperature and pressure of the steam. The same is true of thevalves 12; because they are made of polysulphone (or another suitable plastics material), they will withstand the in-line steam sterilization without damage. - Once steam sterilization is complete, water can be drained by fully opening the
drainage port valve 12 and the filter assembly reconnected for filtering fluid. - By separating the
caps housing 10, these parts can be made in different materials to provide the water wettability necessary for thefilter medium 34 and the resistance to in-line steam sterilization necessary for thehousing 10. - It will be appreciated that there are a number of modifications that can be made to the arrangement described above.
- The
valves 12 need not be as described above. Any suitable valves could be used. The plastics material of thehousing 10 need not be polysulphone, it could be any material that is capable of withstanding in-line steam sterilization. Thefilter element 11 need not be clamped in thehousing 10 as described, it could be held in any suitable way. Thecage 37 need not be as described, any suitable cage could be provided. Thefilter medium 34 may be provided with upstream and/or downstream drainage layers.
Claims (1)
1. A filter assembly comprising
a plastics housing providing an inlet port and an outlet port, the material of the housing being such that the assembly can be sterilized by subjecting the interior of the housing to steam under pressure while the exterior of the housing is at atmospheric pressure without damaging the housing,
a filter element held in the housing and comprising
a filter medium of water wettable material having a central passage extending between first and second ends of the filter medium,
the first end of the filter medium being embedded in a first end cap of a plastics material at a first joint to close said passage and the second end of the filter medium being embedded in a second end cap of a plastics material at a second joint, wherein the characteristics of the filter medium at the joints are not materially changed,
said second end cap providing a fluid connection between said passage and one of said ports,
the first and second end caps forming respective water-wettable joints with the filter medium.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/694,404 US20050145559A1 (en) | 1997-07-16 | 2003-10-28 | Filter assembly |
US11/299,841 US20060091060A1 (en) | 1997-07-16 | 2005-12-13 | Filter assemblies and valves for filter assemblies |
US11/393,785 US7273550B2 (en) | 1997-07-16 | 2006-03-31 | Filter assemblies with valves |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9714965.2 | 1997-07-16 | ||
GB9714965A GB2327369B (en) | 1997-07-16 | 1997-07-16 | Filter assembly |
PCT/GB1998/001975 WO1999003568A1 (en) | 1997-07-16 | 1998-07-06 | Filter assembly |
US46276500A | 2000-06-02 | 2000-06-02 | |
US10/694,404 US20050145559A1 (en) | 1997-07-16 | 2003-10-28 | Filter assembly |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/001975 Continuation WO1999003568A1 (en) | 1997-07-16 | 1998-07-06 | Filter assembly |
US09462765 Continuation | 1998-07-06 | ||
US46276500A Continuation | 1997-07-16 | 2000-06-02 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/299,841 Division US20060091060A1 (en) | 1997-07-16 | 2005-12-13 | Filter assemblies and valves for filter assemblies |
US11/393,785 Division US7273550B2 (en) | 1997-07-16 | 2006-03-31 | Filter assemblies with valves |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050145559A1 true US20050145559A1 (en) | 2005-07-07 |
Family
ID=10815938
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/694,404 Abandoned US20050145559A1 (en) | 1997-07-16 | 2003-10-28 | Filter assembly |
US11/299,841 Abandoned US20060091060A1 (en) | 1997-07-16 | 2005-12-13 | Filter assemblies and valves for filter assemblies |
US11/393,785 Expired - Fee Related US7273550B2 (en) | 1997-07-16 | 2006-03-31 | Filter assemblies with valves |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/299,841 Abandoned US20060091060A1 (en) | 1997-07-16 | 2005-12-13 | Filter assemblies and valves for filter assemblies |
US11/393,785 Expired - Fee Related US7273550B2 (en) | 1997-07-16 | 2006-03-31 | Filter assemblies with valves |
Country Status (10)
Country | Link |
---|---|
US (3) | US20050145559A1 (en) |
EP (2) | EP1321699B1 (en) |
JP (2) | JP2001510088A (en) |
AU (1) | AU734627B2 (en) |
CA (1) | CA2296400A1 (en) |
DE (2) | DE69836021T2 (en) |
DK (1) | DK0998343T3 (en) |
ES (1) | ES2272000T3 (en) |
GB (1) | GB2365511B (en) |
WO (1) | WO1999003568A1 (en) |
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US20080223789A1 (en) * | 2005-09-16 | 2008-09-18 | Technische Universiteit Delft | Material and a method for removing oxo-anions and metal cations from a liquid |
US20090289006A1 (en) * | 2005-12-15 | 2009-11-26 | Yoshinori Nakajima | Filter Unit |
WO2011161088A3 (en) * | 2010-06-23 | 2012-03-15 | Stobbe Tech. A/S | Biopharmaceutical process apparatuses assembled into a column |
US20180339817A1 (en) * | 2015-07-03 | 2018-11-29 | Sonderhoff Engineering Gmbh | Valve device for at least one liquid plastic component |
US10656046B2 (en) | 2014-12-30 | 2020-05-19 | Emd Millipore Corporation | Aseptic filter vent valve and port for integrity testing |
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AUPQ739100A0 (en) * | 2000-05-09 | 2000-06-01 | Fletcher, Clive Allen John | A filtration device |
EP2292297B1 (en) | 2002-04-26 | 2020-06-03 | EMD Millipore Corporation | Disposable steam sterilisable medical valve |
US7293477B2 (en) | 2003-12-23 | 2007-11-13 | Millipore Corporation | Disposable, pre-sterilized fluid receptacle sampling device |
KR100732412B1 (en) * | 2004-09-17 | 2007-06-27 | 삼성전자주식회사 | Filter Assembly and Clothes and Dish Washers Having the Same |
CL2008002533A1 (en) * | 2007-10-20 | 2009-10-09 | Porous Media Corp | A filter assembly comprising a hollow casing open at least at one end at least one closure member that closes the at least one end, the removable closure member being, at least one tubular plate, one or plus holes or openings, an inlet bimpellent chamber formed in the hollow housing |
US20090188856A1 (en) * | 2007-10-20 | 2009-07-30 | Robb Benson | Externally Centering Filter Element or Cartridge and Housing and System Utilizing the Same |
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US20100116732A1 (en) * | 2008-11-07 | 2010-05-13 | Jung Chang-Moo | In-line strainer |
FR2940439B1 (en) | 2008-12-18 | 2011-02-11 | Millipore Corp | DEVICE FOR TRANSFERRING A MEDIUM |
FR2940440B1 (en) | 2008-12-18 | 2010-12-24 | Millipore Corp | DEVICE FOR TRANSFERRING A MEDIUM |
US8544497B2 (en) | 2009-10-30 | 2013-10-01 | Emd Millipore Corporation | Fluid transfer device and system |
DE102010005390A1 (en) * | 2010-01-22 | 2011-07-28 | MAHLE International GmbH, 70376 | filtering device |
KR101173423B1 (en) * | 2012-02-24 | 2012-08-10 | 박대석 | Filter Housing Having Vent Port |
DE102012008471B4 (en) | 2012-04-27 | 2018-05-24 | Sartorius Stedim Biotech Gmbh | Filter element with improved testability after dry steaming, process for its preparation and its use |
KR101545671B1 (en) * | 2013-08-21 | 2015-08-21 | 주식회사 청수테크노필 | Micro filter and manufacture method thereof |
KR101530666B1 (en) * | 2013-08-21 | 2015-06-29 | 주식회사 청수테크노필 | Micro filter and manufacture method thereof |
US9228683B2 (en) * | 2013-12-22 | 2016-01-05 | Saint-Gobain Performance Plastics Corporation | Flanged tube apparatus |
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KR102489816B1 (en) | 2016-01-22 | 2023-01-19 | 백스터 인터내셔널 인코포레이티드 | Method and machine for producing sterile solution product bags |
US11383188B2 (en) * | 2019-06-07 | 2022-07-12 | Pall Corporation | Filter capsule and method of use |
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US10656046B2 (en) | 2014-12-30 | 2020-05-19 | Emd Millipore Corporation | Aseptic filter vent valve and port for integrity testing |
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Also Published As
Publication number | Publication date |
---|---|
DK0998343T3 (en) | 2006-10-23 |
DE69836021D1 (en) | 2006-11-09 |
JP2001510088A (en) | 2001-07-31 |
EP0998343A1 (en) | 2000-05-10 |
DE69839971D1 (en) | 2008-10-16 |
EP1321699B1 (en) | 2008-09-03 |
EP1321699A3 (en) | 2004-10-06 |
GB0126508D0 (en) | 2002-01-02 |
AU8230998A (en) | 1999-02-10 |
GB2365511B (en) | 2002-03-27 |
US20060091060A1 (en) | 2006-05-04 |
AU734627B2 (en) | 2001-06-21 |
EP0998343B1 (en) | 2006-09-27 |
US7273550B2 (en) | 2007-09-25 |
ES2272000T3 (en) | 2007-04-16 |
CA2296400A1 (en) | 1999-01-28 |
JP2009022952A (en) | 2009-02-05 |
EP1321699A2 (en) | 2003-06-25 |
WO1999003568A1 (en) | 1999-01-28 |
DE69836021T2 (en) | 2007-04-05 |
US20060169630A1 (en) | 2006-08-03 |
GB2365511A (en) | 2002-02-20 |
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