US20050027157A1 - System and method for the treatment of spinal metastases - Google Patents
System and method for the treatment of spinal metastases Download PDFInfo
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- US20050027157A1 US20050027157A1 US10/867,062 US86706204A US2005027157A1 US 20050027157 A1 US20050027157 A1 US 20050027157A1 US 86706204 A US86706204 A US 86706204A US 2005027157 A1 US2005027157 A1 US 2005027157A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
- A61N2005/1003—Intraluminal radiation therapy having means for centering a radioactive source within the lumen, e.g. balloons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1021—Radioactive fluid
Definitions
- the present invention relates generally to apparatus for use in treating proliferative tissue disorders, and more particularly to an apparatus for the treatment of such disorders in the body by the application of radiation.
- Cancer tumors are often treated by surgical resection of the tumor to remove as much of the tumor as possible. Infiltration of the tumor cells into normal tissue surrounding the tumor, however, can limit the therapeutic value of surgical resection because the infiltration can be difficult or impossible to treat surgically.
- Radiation therapy can be used to supplement surgical resection by targeting the residual tumor margin after resection, with the goal of reducing its size or stabilizing it. Radiation therapy, or surgical excision followed by radiation therapy, is commonly used to treat spinal metastases. Metastases are tumors that have grown in a location that is remote from the site that the tumor started, and spinal metastases result from the spread of cancer cells into a patient's vertebral column.
- Radiation therapy can be administered through one of several methods, or a combination of methods, including external-beam radiation, stereotactic radiosurgery, and permanent or temporary interstitial brachytherapy.
- brachytherapy refers to radiation therapy delivered by a spatially confined radioactive material inserted into the body at or near a tumor or other proliferative tissue disease site. Owing to the proximity of the radiation source, brachytherapy offers the advantage of delivering a more localized dose to the target tissue region.
- brachytherapy is performed by implanting radiation sources directly into the tissue to be treated.
- Brachytherapy is most appropriate where 1) malignant tumor regrowth occurs locally, within 2 or 3 cm of the original boundary of the primary tumor site; 2) radiation therapy is a proven treatment for controlling the growth of the malignant tumor; and 3) there is a radiation dose-response relationship for the malignant tumor, but the dose that can be given safely with conventional external beam radiotherapy is limited by the tolerance of normal tissue.
- radiation doses are highest in close proximity to the radiotherapeutic source, providing a high tumor dose while sparing surrounding normal tissue.
- Interstitial brachytherapy is useful for treating malignant brain and breast tumors, among others.
- a number of cancers including spinal cancers as well as other thoracic cancers, can proliferate into a patient's spine.
- a brachytherapy device having a catheter member including a proximal portion, a distal portion, and at least one lumen extending therethrough.
- the distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of at least one of a patient's spinous process.
- the device further includes first and second elongate anchoring elements disposed on the first and second branch members. The device is adapted to receive a radiation source through the at least one lumen in the catheter to the first and second branch members for delivering radiation to tissue surrounding the at least one spinous process.
- the device can also optionally include at least one centering mechanism disposed on each of the first and second branch members.
- Each centering mechanism is effective to maintain symmetry of the first and second branch members with respect to a patient's spinal column, and/or to receive a radiation source and to deliver the source to a treatment site.
- the first and second anchoring elements are preferably adapted to be positioned between a spinous process and transverse process of at least one vertebral body, and to extend along a length of a patient's spinal column, such that the first and second anchoring elements, when expanded, engage and anchor the first and second branch members between the spinous process and transverse process of at least one vertebral body.
- the first and second elongate anchoring elements each have a length adapted to span a plurality of vertebrae.
- first and second anchoring elements can be first and second outer expandable balloons, and each centering mechanism can be an inner expandable balloon.
- Each inner expandable balloon preferably has a size adapted to receive a predetermined amount of a fluid radiation source such that varying doses of radiation can be delivered along a length of the outer expandable balloon. More preferably, each inner expandable balloon is effective to position a radiation source at a predetermined distance apart from the first and second outer expandable balloon to provide a minimum absorbed dose for delivering radiation to tissue adjacent to the outer expandable balloons.
- a brachytherapy device including an elongate catheter member having a proximal portion, a distal portion, an inflation lumen, and at least one source lumen.
- a plurality of inner centering mechanisms are disposed around the catheter member and are in communication with a source lumen.
- the device is adapted to receive a radiation source to deliver radiation to tissue surrounding the device.
- the device can also optionally include an outer anchoring member disposed around the distal portion of the catheter member and in communication with the inflation lumen.
- the outer anchoring member is adapted to anchor the catheter member between a spinous process and transverse process of at least one vertebral body, and to extend along a length of a patient's spinal column.
- the plurality of centering mechanisms are preferably disposed within the outer anchoring member and are effective to maintain symmetry along a length of the distal portion of the elongate catheter member.
- a method for treating spinal metastases includes the step of providing at least one brachytherapy apparatus for delivering radioactive emissions.
- the apparatus has a catheter member having proximal and distal ends and at least one lumen extending therethrough, at least one anchoring element disposed proximate to the distal end of the catheter, and a radiation source disposable through the at least one lumen in the catheter for delivering radiation to the tissue surrounding the anchoring element.
- the method further includes the steps of intraoperatively placing at least one brachytherapy apparatus between a spinous process and transverse process of at least one vertebral body along a length of the patient's spinal column, providing a controlled dose of radiation to tissue surrounding the apparatus, and removing the brachytherapy apparatus.
- the radiation source is preferably placed into the brachytherapy apparatus after placement of the apparatus between the spinous process and transverse process of at least one vertebral body, and is removed from the apparatus before removal of the apparatus.
- FIG. 1 is perspective view illustration of one embodiment of a brachytherapy system for proliferative tissue disorders in a patient's spinal column;
- FIG. 2 is a perspective view illustration of another embodiment of a brachytherapy system for proliferative tissue disorders in a patient's spinal column;
- FIG. 3 is a diagram illustrating one embodiment of a branch member for use with the system of the present invention.
- FIG. 4 is an illustration of a brachytherapy system according to the present invention positioned between a patient's spinous process and transverse process of several adjacent vertebrae.
- the present invention generally provides a radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue and/or bone. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases, and more particularly, to treat metastases on and around a patient's spinous process.
- FIG. 1 illustrates one embodiment of the device which generally includes a catheter member 10 having a proximal portion 12 , a distal portion 14 , and at least one lumen extending therethrough. As shown in FIG. 1 , the catheter member 10 includes first and second lumens 16 , 18 extending through the proximal and distal portions 12 , 14 .
- the distal portion 14 of the catheter 10 includes first and second branch members 20 , 22 which are preferably adapted to be positioned on opposed sides of a patient's spinous process.
- Each branch member 20 , 22 includes an anchoring element 24 , 26 disposed on at least a portion thereof for anchoring the branch members 20 , 22 at the treatment site.
- the first and second branch members 20 , 22 can also be adapted to receive a radiation source through at least one of the lumens 16 , 18 (or another lumen) formed in the catheter 10 .
- the radiation source can generally be provided as a solid radiation source which can be loaded into the lumen using a conventional afterloader or as a liquid radiation source which can be loaded, for example, into anchoring elements 24 , 26 using the lumen or lumens.
- the device is particularly advantageous in that it allows radiation to be delivered to specific regions of a patient's spine and surrounding tissue. Moreover, the treatment can be tailored depending on the intended treatment site.
- the catheter member 10 can have a variety of configurations, but is preferably a semi-flexible or flexible elongate member having a proximal portion 12 and a distal portion 14 having first and second branch members 20 , 22 . Flexibility (or semi-flexibility) in catheter member 10 can allow the catheter member to be adapted to the curvature of a particular patient's spine.
- the catheter 10 further includes at least one lumen formed therein that extends through the proximal portion 12 and the first and second branch members 20 , 22 of the distal portion 14 .
- a first lumen 16 extends through the proximal portion 12 and the first branch member 20
- a second, separate lumen 18 extends through the proximal portion 12 and the second branch member 22 .
- the lumens 16 , 18 can each terminate at a distal port 34 , 36 formed in the first and second branch members 20 , 22 , respectively.
- the branch members 20 , 22 can be integrally formed with the proximal portion 12 of the catheter 10 , or alternatively can be mated to the proximal portion 12 using a variety of mating techniques. As shown in FIG. 1 , the first and second branch members 20 , 22 are mated to the proximal portion 12 of the catheter 10 via a Y-shaped connector element 32 .
- the Y-shaped connector element 32 includes a proximal end 32 a that can be fixedly or removably mated to the proximal portion 12 of the catheter 10 , and first and second distal ends 32 b , 32 c .
- the first distal end 32 b can be fixedly or removably mated to the first branch member 20
- the second distal end 32 c can be fixedly or removably mated to the second branch member 22 .
- a variety of mating techniques can be used for mating the proximal portion 12 and the first and second branch members 20 , 22 of the catheter 10 to the connector 32 including, for example, a threaded engagement, a twist lock engagement, a snap-fit engagement, and any other mechanical and/or electrical engagement mechanism.
- a Y-shaped connector 32 is shown, a variety of connectors can be used to mate the first and second branch members 20 , 22 to the proximal portion 12 of the catheter 10 .
- Each branch member 20 , 22 can have a variety of shapes and sizes, but preferably each branch member 20 , 22 has a generally elongate shape and is adapted to be positioned on opposed sides of a patient's spinous process, preferably between the spinous process and the transverse process, across one or more of the patient's vertebrae. As shown in FIG. 1 , the first and second branch members 20 , 22 each have a generally elongate shape and extend in a direction substantially parallel to a longitudinal axis A of the device.
- the branch members 20 , 22 can be substantially rigid, but are preferably substantially flexible to facilitate insertion of the branch members 20 , 22 between the spinous process and transverse process of one or more vertebrae in various portions of the patient's spine which may have differing curvatures.
- the branch members 20 , 22 are sufficiently flexible to allow the shape of each branch member 20 , 22 to be adjusted during use of the device 10 to conform to the curvature of the portion of the patient's spine being treated.
- anchoring members 24 , 26 are preferably sufficiently malleable (or can be placed in a sufficiently malleable state) to allow for placement of branch members 20 , 22 in irregular spaces between vertebral processes or to adapt to spinal curvature.
- branch members 20 , 22 While two branch members 20 , 22 are shown, a person having ordinary skill in the art will appreciate that the catheter 10 can have a single branch member, or any number of branch members. However, for treatment of cancerous proliferation in a patient's spine by fitting branch members 20 , 22 to a patient's spinal process or processes, a person of ordinary skill in the art will recognize that either two or one branches will be preferred and that, for dosing symmetry purposes, under certain circumstances two branches will be preferred.
- each branch member 20 , 22 can also vary depending on the intended use, but preferably each branch member 20 , 22 has a length L that is sufficient to allow the branch members 20 , 22 to extend along a plurality of vertebrae. In an exemplary embodiment, each branch member 20 , 22 has a length L between about 4 cm and 12 cm. As previously stated, the branch members 20 , 22 can be removably mated to the connector 32 . Thus, the catheter 10 can be provided as a kit having several branch members with varying lengths to allow the appropriately sized branch members to be selected.
- Each branch member 20 , 22 further includes first and second anchoring members 24 , 26 disposed thereon.
- the anchoring members 24 , 26 can have a variety of configurations and are preferably effective to engage and anchor each branch member 20 , 22 between the spinous process and the transverse process of at least one vertebral body.
- each anchoring member 24 , 26 is an expandable balloon member that is primarily sealed around the branch member 20 , 22 and is in communication with one of the lumens 16 , 18 .
- the port 34 that is in communication with the first lumen 16 is disposed within the first anchoring member 24 for expanding the first anchoring element
- the port 36 that is in communication with the second lumen 18 is disposed within the second anchoring element 26 for expanding the second anchoring element.
- the anchoring elements 24 , 26 are movable between a deflated position to allow positioning of the first and second branch members 20 , 22 between the spinous process and transverse process of one or more vertebral bodies, and an inflated position, as shown, wherein air or fluid is delivered through the lumen 16 , 18 and the port 34 , 36 in each of the first and second branch members 20 , 22 to inflate the anchoring elements 24 , 26 and thereby anchor the first and second branch members 20 , 22 between the spinous process and transverse process.
- the anchoring elements 24 , 26 can have any shape and size, but preferably each element 24 , 26 has a predetermined shape in its expanded form, as shown in FIG. 1 , such that, when inflated, the anchoring elements 24 , 26 are adapted to securely fit between the spinous process and the transverse process to positively locate the branch members 20 , 22 with respect to the target tissue to be dosed with radiation. While the size of the anchoring elements 24 , 26 can be predetermined, the size can be selectable during treatment by inflating the anchoring elements 24 , 26 to a desired level.
- each anchoring element 24 , 26 can be an expandable cage member, and the catheter 10 can optionally include a control lever or similar mechanism for moving the expandable cage members between a contracted position and an expanded position.
- This configuration, as well as a number of inflatable balloon, double balloon, and other expandable surface member anchoring members as well as their operation and association with one or more lumens within device 10 is described in more detail in U.S. Pat. No. 6,413,204, issued Jul. 2, 2002, and entitled “Interstitial Brachytherapy Apparatus and Method for Treatment of Proliferative Tissue Diseases,” which is incorporated herein by reference.
- a person having ordinary skill in the art will appreciate that a variety of anchoring elements can be used with the present invention.
- FIG. 2 illustrates another embodiment of a catheter 40 according to the present invention.
- the catheter 40 is similar to catheter 10 in that it includes a proximal portion 42 , a distal portion 44 having first and second branch members 46 , 48 , and a connector 50 disposed therebetween.
- the catheter 40 also includes first and second anchoring elements 52 , 54 disposed on the first and second branch members 46 , 48 and effective to anchor the branch members 46 , 48 between a spinous process and transverse process of at least one vertebral body.
- First and second lumens 56 , 58 extend through the catheter 40 and include distal portions (not shown) in communication with the first and second anchoring elements 52 , 54 for inflating the anchoring elements 52 , 54 .
- the connector 50 differs in shape. As shown, the connector 50 , rather than having a Y-shape, has a substantially straight portion 60 that extends between the proximal portion 42 and the second branch member 48 , and a side-arm 62 that extends outward from the straight portion 60 and mates to the first branch member 46 . This configuration allows the second branch member 54 to be positioned along one side of the spinous process and the first branch member 52 to extend around and along the other side of the spinous process.
- Catheter member 40 further includes at least one centering mechanism 64 , 66 disposed within each of the first and second anchoring elements 52 , 54 .
- the centering mechanisms 64 , 66 can have a variety of configurations, and can be effective to maintain symmetry of the first and second branch members with respect to the patient's spinal column, and/or to receive a radiation source and to deliver the source uniformly to a treatment site. As shown in FIG. 2 , the centering mechanisms 64 , 66 are expandable balloon members that are adapted to fit within the outer anchoring element 52 , 54 .
- the centering mechanisms 64 , 66 When inflated, the centering mechanisms 64 , 66 can be spaced a predetermined distance apart from the outer anchoring element 52 , 54 and/or each other, or alternatively the centering mechanism 64 , 66 can engage the anchoring elements 52 , 54 upon inflation.
- Each centering mechanism 64 , 66 can also vary in shape and size, depending on the intended use. The size can, however, be selectable during treatment by inflating each centering mechanism 64 , 66 to a desired level.
- the number of centering mechanism 64 , 66 used can also vary depending on the intended use and on the length of the first and second branch members 46 , 48 .
- branch members 46 , 48 that have a length adapted to extend across several vertebrae include one or more centering mechanisms 64 , 66 to assist in positioning each branch member between the spinous process and transverse process of each vertebra.
- each centering mechanism 64 , 66 is in communication with a lumen in the catheter 40 for inflating the centering mechanisms 64 , 66 .
- the catheter 40 includes four lumens 56 , 57 , 58 , 59 .
- the first and second lumens 56 , 58 include one or more ports (not shown) that communicate with the first and second anchoring elements 52 , 54 , respectively.
- the third lumen 57 can include a port (not shown) disposed within each centering mechanism 64 in the first branch member 46
- the fourth lumen 59 can include a port (not shown) disposed within each centering mechanism 66 in the second branch member 48 .
- FIG. 3 illustrates the second branch member 48 having inner lumen 58 (shown in FIG. 2 ) in communication with port 55 disposed within anchoring element 54 .
- FIG. 3 further illustrates each centering mechanism 66 having a port 67 disposed therein.
- centering mechanisms 64 , 66 can be separately expandable or inflatable by, for example, providing separate lumens to each centering mechanism to allow for selective inflation.
- centering mechanisms 64 , 66 are inflated with a radioactive treatment fluid to treat the target proliferative tissue
- this configuration can allow selective treatment (by providing differing doses from the centering mechanisms) along the lengths of branch members 46 and 48 as well.
- centering mechanisms 64 , 66 can, in one embodiment, perform the function of anchoring elements 52 , 54 , thus obviating the need to have separate anchoring elements.
- anchoring elements and the centering mechanisms can be formed from a polymeric film wall, which may comprise a biocompatible, radiation resistant polymer. Suitable polymers include, for example, silastic rubbers, polyurethanes, polyethylene, polypropylene, polyester, and PVC. Still further, the centering mechanisms can be formed according to the balloon and/or expandable surface elements described in U.S. Pat. No. 6,413,204, issued Jul. 2, 2002, and entitled “Interstitial Brachytherapy Apparatus and Method for Treatment of Proliferative Tissue Diseases,” which has been incorporated herein by reference above.
- FIG. 4 illustrates one embodiment of a spinous process catheter 80 having a single branch member 82 .
- a surgeon intra-operatively places the branch member 82 of the catheter 80 into a patient's spinal column and guides it between the spinous process 84 and transverse process 86 of one or more vertebrae.
- a first branch member is positioned on one side of the spinous process
- a second branch member is positioned on the second side of a patient's spinous process.
- the anchoring element 88 can then be inflated with air or other fluids, such as saline or a radiation absorbing fluid such as a contrast media used in angiography. Where centering mechanisms are provided, one or more of the centering mechanisms can optionally also be inflated with air or other fluids.
- the catheter 80 can be pre-loaded with a radioactive source, or alternatively the radioactive source can be inserted into the catheter 80 via one of the lumens (not shown).
- a radioactive source or alternatively the radioactive source can be inserted into the catheter 80 via one of the lumens (not shown).
- one or more solid radioactive seeds may form the radioactive source.
- the seed or seeds can be located within a lumen in branch member 82 by locating the seed or seeds on a wire that can be moved into, caused to dwell in, then be removed from the lumen using an afterloader such as those commonly found in hospitals in which radiotherapy is applied.
- the radioactive source especially where the radioactive source is provided in the form of a liquid, can be disposed within one or more of the centering mechanism or within the anchoring element 88 .
- the radioactive source dwells in each centering mechanism until the prescribed dose of radiotherapy is delivered, or the radioactive source can be inserted for prescribed amounts of time on a daily or other scheduled basis until the prescribed dosage has been achieved.
- the radioactive source is then retrieved and the catheter 80 is removed.
- the application of radiotherapy using a radioactive source within catheter 80 can also be performed according to the many descriptions and examples provided in U.S. Pat. No. 6,413,204, issued Jul. 2, 2002, and entitled “Interstitial Brachytherapy Apparatus and Method for Treatment of Proliferative Tissue Diseases,” which has been incorporated herein by reference above.
- the radiation treatment may end upon removal of the brachytherapy apparatus 80 , or the brachytherapy may be supplemented by further doses of radiation supplied externally.
- Suitable radiation sources for use with the system of the present invention include both solids and liquids.
- the radiation source can be a radionuclide, such as I-125, I-131, Yb-169, Ir-192 as a solid source, I-125 as a solid source, or other radionuclides that emit photons, beta particles, gamma radiation, or other therapeutic rays.
- the radioactive material can also be a fluid made from any solution of radionuclide(s), e.g., a solution of I-125 or I-131, or a radioactive fluid can be produced using a slurry of a suitable fluid containing small particles of solid radionuclides, such as Au-198, Y-90.
- radionuclide(s) can be embodied in a gel.
- One radioactive material useful in the invention is IotrexTM, a sterile single use, non-pyrogenic solution containing sodium 3-( 125 I)iodo-4-hydroxybenzenesulfonate ( 125 I-HBS), available from Proxima Therapeutics, Inc. of Alpharetta, Ga.
- Solid radioactive micro spheres of the type available from the 3M Company of St. Paul, Minn., may also be used.
- This radioactive source can either be preloaded into the catheter at the time of manufacture or loaded into the device after it has been implanted into the space formerly occupied by the excised tumor with one or more solid radioactive micro spheres inserted through the catheter on a wire, for example, using an afterloader (not shown).
- the solid radioactive source embodiment may also be used to selectively apply radiotherapy along the length of catheter 80 .
- a plurality of seeds can be provided in a spaced relation along a wire so that they are located proximate to the region of selective treatment. Alternatively, one or more seeds can be moved by the afterloader so as to provided desired dwell times proximate to regions of selective treatment.
- the system of the present invention can also have a variety of other configurations.
- the device can be adapted to control the distribution of radiation to tissue surrounding the treatment site.
- One advantage to controlling the distribution of radiation to tissue surrounding the treatment site is that a minimum prescribed dose can be delivered to the tissue in the target treatment region without over-exposing radiation-sensitive tissue, which can cause healthy tissue necrosis.
- each centering mechanism 64 , 66 can be effective to receive a radiation source and to position the radiation source a predetermined distance apart from each anchoring element 52 , 54 , thereby providing a minimum absorbed dose for delivering radiation to tissue adjacent the anchoring element. This configuration is described in more detail in U.S. Pat. No. 6,413,204, issued Jul.
- the centering mechanisms and the anchoring elements have a volume that is configured to provide an absorbed dose within a predetermined range throughout a target tissue.
- At least one of the anchoring element 52 , 54 and/or the centering mechanisms 64 , 66 can be partially coated with a radio-opaque material effective to shield radiation sensitive tissue from a portion of the radiation source.
- the coating (not shown) can be strategically positioned to shield radiation sensitive tissue, and/or to provide an asymmetric isodose curve as described in U.S. Pat. No. 6,482,142, issued on Nov. 19, 2002, and entitled “Asymmetric Radiation Dosing Apparatus and Method,” which is incorporated herein by reference.
- Radio-opaque materials suitable for coating onto an expandable surface include, for example, barium, tungsten, bismuth, tantalum, and tin.
- a radiation-blocking or absorbing shield (not shown) can be positioned between each anchoring element and the centering mechanisms disposed therein, or within the centering mechanisms to produce a desired isodose curve.
- longitudinal shielding could be provided between the radiation source and the patient's spinal cord in order to treat cancerous tissue in and around the spine while protecting the spinal cord from radiation.
- the radiation source itself can be configured to provide radiation to a desired region of tissue surrounding the interstitial space.
- the radiation source can comprise a wire having one or more solid radioactive particles located thereon.
- the radioactive source can either be preloaded into the catheter at the time of manufacture, or loaded into the device after it has been implanted into the space formerly occupied by the excised tumor. If loaded after implantation, the solid radiation emitting material can be inserted through one of the lumens 56 , 57 , 58 , 59 (or through another lumen) on a wire, for example, using an afterloader (not shown).
- the catheter 40 may need to be adapted to have a size sufficient to receive such a radiation source.
- the radiation source has an asymmetric configuration with respect to a longitudinal axis of the instrument. That is, radiation source is shaped so as to result in an isodose profile that varies radially about the longitudinal axis A.
- the asymmetrically shaped isodose curve may be created by providing a plurality of solid radioactive particles on a curved wire in a spaced apart relationship. This configuration will result in certain of the solid radioactive particles being farther from the longitudinal axis of the instrument than others, and will result in the illustrated asymmetric isodose profile.
- One way to provide the radioactive source configuration is to form wire from a solid or tubular shape memory alloy such as nickel-titanium alloys known in the art to have such properties. Wire can then be preformed to the desired shape, can be compressed into a substantially straight configuration to pass through the first lumen, and will resume its desired shape once inside volume where wire will be free from steric constraints imposed inside the first lumen.
- the resulting asymmetric isodose curve can be further tailored by using solid radioactive particles having differing specific activities to achieve the desired dosing.
- Such a configuration is described in more detail in U.S. Pat. No. 6,482,142, issued on Nov. 19, 2002, and entitled “Asymmetric Radiation Dosing Apparatus and Method.”
Abstract
Description
- The present invention relates generally to apparatus for use in treating proliferative tissue disorders, and more particularly to an apparatus for the treatment of such disorders in the body by the application of radiation.
- Malignant tumors are often treated by surgical resection of the tumor to remove as much of the tumor as possible. Infiltration of the tumor cells into normal tissue surrounding the tumor, however, can limit the therapeutic value of surgical resection because the infiltration can be difficult or impossible to treat surgically. Radiation therapy can be used to supplement surgical resection by targeting the residual tumor margin after resection, with the goal of reducing its size or stabilizing it. Radiation therapy, or surgical excision followed by radiation therapy, is commonly used to treat spinal metastases. Metastases are tumors that have grown in a location that is remote from the site that the tumor started, and spinal metastases result from the spread of cancer cells into a patient's vertebral column.
- Radiation therapy can be administered through one of several methods, or a combination of methods, including external-beam radiation, stereotactic radiosurgery, and permanent or temporary interstitial brachytherapy. The term “brachytherapy,” as used herein, refers to radiation therapy delivered by a spatially confined radioactive material inserted into the body at or near a tumor or other proliferative tissue disease site. Owing to the proximity of the radiation source, brachytherapy offers the advantage of delivering a more localized dose to the target tissue region.
- For example, brachytherapy is performed by implanting radiation sources directly into the tissue to be treated. Brachytherapy is most appropriate where 1) malignant tumor regrowth occurs locally, within 2 or 3 cm of the original boundary of the primary tumor site; 2) radiation therapy is a proven treatment for controlling the growth of the malignant tumor; and 3) there is a radiation dose-response relationship for the malignant tumor, but the dose that can be given safely with conventional external beam radiotherapy is limited by the tolerance of normal tissue. In brachytherapy, radiation doses are highest in close proximity to the radiotherapeutic source, providing a high tumor dose while sparing surrounding normal tissue. Interstitial brachytherapy is useful for treating malignant brain and breast tumors, among others.
- While devices exist for delivering radiation to treat metastases, there is still a need for instruments which can be used to provide brachytherapy to target tissue within specific areas of a human body, such as within a patient's spine. In particular, a number of cancers, including spinal cancers as well as other thoracic cancers, can proliferate into a patient's spine. At present, there are no devices configured for treatment of such proliferation, especially where the proliferation extends through more than one vertebra within the spine.
- The present invention generally provides a brachytherapy system for treating metastases on and around a patient's spinous process. In one embodiment, a brachytherapy device is provided having a catheter member including a proximal portion, a distal portion, and at least one lumen extending therethrough. The distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of at least one of a patient's spinous process. The device further includes first and second elongate anchoring elements disposed on the first and second branch members. The device is adapted to receive a radiation source through the at least one lumen in the catheter to the first and second branch members for delivering radiation to tissue surrounding the at least one spinous process. The device can also optionally include at least one centering mechanism disposed on each of the first and second branch members. Each centering mechanism is effective to maintain symmetry of the first and second branch members with respect to a patient's spinal column, and/or to receive a radiation source and to deliver the source to a treatment site.
- The first and second anchoring elements are preferably adapted to be positioned between a spinous process and transverse process of at least one vertebral body, and to extend along a length of a patient's spinal column, such that the first and second anchoring elements, when expanded, engage and anchor the first and second branch members between the spinous process and transverse process of at least one vertebral body. In an exemplary embodiment, the first and second elongate anchoring elements each have a length adapted to span a plurality of vertebrae.
- In another embodiment, the first and second anchoring elements can be first and second outer expandable balloons, and each centering mechanism can be an inner expandable balloon. Each inner expandable balloon preferably has a size adapted to receive a predetermined amount of a fluid radiation source such that varying doses of radiation can be delivered along a length of the outer expandable balloon. More preferably, each inner expandable balloon is effective to position a radiation source at a predetermined distance apart from the first and second outer expandable balloon to provide a minimum absorbed dose for delivering radiation to tissue adjacent to the outer expandable balloons.
- In yet another embodiment, a brachytherapy device is provided including an elongate catheter member having a proximal portion, a distal portion, an inflation lumen, and at least one source lumen. A plurality of inner centering mechanisms are disposed around the catheter member and are in communication with a source lumen. In use, the device is adapted to receive a radiation source to deliver radiation to tissue surrounding the device. The device can also optionally include an outer anchoring member disposed around the distal portion of the catheter member and in communication with the inflation lumen. The outer anchoring member is adapted to anchor the catheter member between a spinous process and transverse process of at least one vertebral body, and to extend along a length of a patient's spinal column. The plurality of centering mechanisms are preferably disposed within the outer anchoring member and are effective to maintain symmetry along a length of the distal portion of the elongate catheter member.
- In yet another embodiment of the present invention, a method for treating spinal metastases is provided. The method includes the step of providing at least one brachytherapy apparatus for delivering radioactive emissions. The apparatus has a catheter member having proximal and distal ends and at least one lumen extending therethrough, at least one anchoring element disposed proximate to the distal end of the catheter, and a radiation source disposable through the at least one lumen in the catheter for delivering radiation to the tissue surrounding the anchoring element. The method further includes the steps of intraoperatively placing at least one brachytherapy apparatus between a spinous process and transverse process of at least one vertebral body along a length of the patient's spinal column, providing a controlled dose of radiation to tissue surrounding the apparatus, and removing the brachytherapy apparatus. The radiation source is preferably placed into the brachytherapy apparatus after placement of the apparatus between the spinous process and transverse process of at least one vertebral body, and is removed from the apparatus before removal of the apparatus.
- The foregoing features, objects and advantages of the invention will become apparent to those skilled in the art from the following detailed description of a preferred embodiment, especially when considered in conjunction with the accompanying drawings in which:
-
FIG. 1 is perspective view illustration of one embodiment of a brachytherapy system for proliferative tissue disorders in a patient's spinal column; -
FIG. 2 is a perspective view illustration of another embodiment of a brachytherapy system for proliferative tissue disorders in a patient's spinal column; -
FIG. 3 is a diagram illustrating one embodiment of a branch member for use with the system of the present invention; -
FIG. 4 is an illustration of a brachytherapy system according to the present invention positioned between a patient's spinous process and transverse process of several adjacent vertebrae. - The present invention generally provides a radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue and/or bone. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases, and more particularly, to treat metastases on and around a patient's spinous process.
FIG. 1 illustrates one embodiment of the device which generally includes acatheter member 10 having aproximal portion 12, adistal portion 14, and at least one lumen extending therethrough. As shown inFIG. 1 , thecatheter member 10 includes first andsecond lumens distal portions distal portion 14 of thecatheter 10 includes first andsecond branch members branch member anchoring element branch members second branch members lumens 16, 18 (or another lumen) formed in thecatheter 10. The radiation source can generally be provided as a solid radiation source which can be loaded into the lumen using a conventional afterloader or as a liquid radiation source which can be loaded, for example, into anchoringelements - The
catheter member 10 can have a variety of configurations, but is preferably a semi-flexible or flexible elongate member having aproximal portion 12 and adistal portion 14 having first andsecond branch members catheter member 10 can allow the catheter member to be adapted to the curvature of a particular patient's spine. Thecatheter 10 further includes at least one lumen formed therein that extends through theproximal portion 12 and the first andsecond branch members distal portion 14. In an exemplary embodiment, afirst lumen 16 extends through theproximal portion 12 and thefirst branch member 20, and a second,separate lumen 18 extends through theproximal portion 12 and thesecond branch member 22. Thelumens distal port second branch members - The
branch members proximal portion 12 of thecatheter 10, or alternatively can be mated to theproximal portion 12 using a variety of mating techniques. As shown inFIG. 1 , the first andsecond branch members proximal portion 12 of thecatheter 10 via a Y-shapedconnector element 32. The Y-shapedconnector element 32 includes aproximal end 32 a that can be fixedly or removably mated to theproximal portion 12 of thecatheter 10, and first and second distal ends 32 b, 32 c. The firstdistal end 32 b can be fixedly or removably mated to thefirst branch member 20, and the seconddistal end 32 c can be fixedly or removably mated to thesecond branch member 22. A variety of mating techniques can be used for mating theproximal portion 12 and the first andsecond branch members catheter 10 to theconnector 32 including, for example, a threaded engagement, a twist lock engagement, a snap-fit engagement, and any other mechanical and/or electrical engagement mechanism. A person having ordinary skill in the art will appreciate that while a Y-shapedconnector 32 is shown, a variety of connectors can be used to mate the first andsecond branch members proximal portion 12 of thecatheter 10. - Each
branch member branch member FIG. 1 , the first andsecond branch members branch members branch members branch members branch member device 10 to conform to the curvature of the portion of the patient's spine being treated. In addition, anchoringmembers branch members - While two
branch members catheter 10 can have a single branch member, or any number of branch members. However, for treatment of cancerous proliferation in a patient's spine by fittingbranch members - The length L of each
branch member branch member branch members branch member branch members connector 32. Thus, thecatheter 10 can be provided as a kit having several branch members with varying lengths to allow the appropriately sized branch members to be selected. - Each
branch member second anchoring members members branch member FIG. 1 , each anchoringmember branch member lumens port 34 that is in communication with thefirst lumen 16 is disposed within the first anchoringmember 24 for expanding the first anchoring element, and theport 36 that is in communication with thesecond lumen 18 is disposed within thesecond anchoring element 26 for expanding the second anchoring element. - In use, the anchoring
elements second branch members lumen port second branch members anchoring elements second branch members - The anchoring
elements element FIG. 1 , such that, when inflated, the anchoringelements branch members elements elements element catheter 10 can optionally include a control lever or similar mechanism for moving the expandable cage members between a contracted position and an expanded position. This configuration, as well as a number of inflatable balloon, double balloon, and other expandable surface member anchoring members as well as their operation and association with one or more lumens withindevice 10 is described in more detail in U.S. Pat. No. 6,413,204, issued Jul. 2, 2002, and entitled “Interstitial Brachytherapy Apparatus and Method for Treatment of Proliferative Tissue Diseases,” which is incorporated herein by reference. A person having ordinary skill in the art will appreciate that a variety of anchoring elements can be used with the present invention. -
FIG. 2 illustrates another embodiment of acatheter 40 according to the present invention. Thecatheter 40 is similar tocatheter 10 in that it includes aproximal portion 42, adistal portion 44 having first andsecond branch members catheter 40 also includes first andsecond anchoring elements second branch members branch members second lumens catheter 40 and include distal portions (not shown) in communication with the first andsecond anchoring elements elements - While the
catheter 40 is very similar tocatheter 10 shown inFIG. 1 , the connector 50 differs in shape. As shown, the connector 50, rather than having a Y-shape, has a substantiallystraight portion 60 that extends between theproximal portion 42 and thesecond branch member 48, and a side-arm 62 that extends outward from thestraight portion 60 and mates to thefirst branch member 46. This configuration allows thesecond branch member 54 to be positioned along one side of the spinous process and thefirst branch member 52 to extend around and along the other side of the spinous process. -
Catheter member 40 further includes at least one centeringmechanism second anchoring elements mechanisms FIG. 2 , the centeringmechanisms outer anchoring element mechanisms outer anchoring element mechanism anchoring elements mechanism mechanism mechanism second branch members branch members mechanisms - In use, each centering
mechanism catheter 40 for inflating the centeringmechanisms catheter 40 includes fourlumens second lumens second anchoring elements third lumen 57 can include a port (not shown) disposed within each centeringmechanism 64 in thefirst branch member 46, and thefourth lumen 59 can include a port (not shown) disposed within each centeringmechanism 66 in thesecond branch member 48. By way of non-limiting example,FIG. 3 illustrates thesecond branch member 48 having inner lumen 58 (shown inFIG. 2 ) in communication withport 55 disposed within anchoringelement 54.FIG. 3 further illustrates each centeringmechanism 66 having aport 67 disposed therein. A person having ordinary skill in the art will appreciate that a variety of configurations can be provided for inflating the anchoringelements mechanisms mechanisms mechanisms branch members mechanisms elements - With no limitation intended, anchoring elements and the centering mechanisms can be formed from a polymeric film wall, which may comprise a biocompatible, radiation resistant polymer. Suitable polymers include, for example, silastic rubbers, polyurethanes, polyethylene, polypropylene, polyester, and PVC. Still further, the centering mechanisms can be formed according to the balloon and/or expandable surface elements described in U.S. Pat. No. 6,413,204, issued Jul. 2, 2002, and entitled “Interstitial Brachytherapy Apparatus and Method for Treatment of Proliferative Tissue Diseases,” which has been incorporated herein by reference above.
- The present invention also provides a method for treating spinal metastases.
FIG. 4 illustrates one embodiment of aspinous process catheter 80 having asingle branch member 82. A person having ordinary skill in the art will appreciate that a variety of catheters can be used, and that the catheter can have any number of branch members for providing radiation to various portions of a patient's spinal column. As shown, a surgeon intra-operatively places thebranch member 82 of thecatheter 80 into a patient's spinal column and guides it between thespinous process 84 andtransverse process 86 of one or more vertebrae. Preferably, where two branch members are used, a first branch member is positioned on one side of the spinous process, and a second branch member is positioned on the second side of a patient's spinous process. The anchoringelement 88 can then be inflated with air or other fluids, such as saline or a radiation absorbing fluid such as a contrast media used in angiography. Where centering mechanisms are provided, one or more of the centering mechanisms can optionally also be inflated with air or other fluids. - The
catheter 80 can be pre-loaded with a radioactive source, or alternatively the radioactive source can be inserted into thecatheter 80 via one of the lumens (not shown). In one embodiment, one or more solid radioactive seeds may form the radioactive source. The seed or seeds can be located within a lumen inbranch member 82 by locating the seed or seeds on a wire that can be moved into, caused to dwell in, then be removed from the lumen using an afterloader such as those commonly found in hospitals in which radiotherapy is applied. The radioactive source, especially where the radioactive source is provided in the form of a liquid, can be disposed within one or more of the centering mechanism or within the anchoringelement 88. Preferably, the radioactive source dwells in each centering mechanism until the prescribed dose of radiotherapy is delivered, or the radioactive source can be inserted for prescribed amounts of time on a daily or other scheduled basis until the prescribed dosage has been achieved. The radioactive source is then retrieved and thecatheter 80 is removed. The application of radiotherapy using a radioactive source withincatheter 80 can also be performed according to the many descriptions and examples provided in U.S. Pat. No. 6,413,204, issued Jul. 2, 2002, and entitled “Interstitial Brachytherapy Apparatus and Method for Treatment of Proliferative Tissue Diseases,” which has been incorporated herein by reference above. The radiation treatment may end upon removal of thebrachytherapy apparatus 80, or the brachytherapy may be supplemented by further doses of radiation supplied externally. - Suitable radiation sources for use with the system of the present invention include both solids and liquids. By way of non-limiting example, the radiation source can be a radionuclide, such as I-125, I-131, Yb-169, Ir-192 as a solid source, I-125 as a solid source, or other radionuclides that emit photons, beta particles, gamma radiation, or other therapeutic rays. The radioactive material can also be a fluid made from any solution of radionuclide(s), e.g., a solution of I-125 or I-131, or a radioactive fluid can be produced using a slurry of a suitable fluid containing small particles of solid radionuclides, such as Au-198, Y-90. Moreover, the radionuclide(s) can be embodied in a gel. One radioactive material useful in the invention is Iotrex™, a sterile single use, non-pyrogenic solution containing sodium 3-(125I)iodo-4-hydroxybenzenesulfonate (125I-HBS), available from Proxima Therapeutics, Inc. of Alpharetta, Ga.
- Solid radioactive micro spheres of the type available from the 3M Company of St. Paul, Minn., may also be used. This radioactive source can either be preloaded into the catheter at the time of manufacture or loaded into the device after it has been implanted into the space formerly occupied by the excised tumor with one or more solid radioactive micro spheres inserted through the catheter on a wire, for example, using an afterloader (not shown). As with the liquid radioactive source embodiment, the solid radioactive source embodiment may also be used to selectively apply radiotherapy along the length of
catheter 80. A plurality of seeds can be provided in a spaced relation along a wire so that they are located proximate to the region of selective treatment. Alternatively, one or more seeds can be moved by the afterloader so as to provided desired dwell times proximate to regions of selective treatment. - The system of the present invention can also have a variety of other configurations. For example, the device can be adapted to control the distribution of radiation to tissue surrounding the treatment site. One advantage to controlling the distribution of radiation to tissue surrounding the treatment site is that a minimum prescribed dose can be delivered to the tissue in the target treatment region without over-exposing radiation-sensitive tissue, which can cause healthy tissue necrosis. By way of non-limiting example, referring to
FIG. 2 , each centeringmechanism element - In another embodiment, at least one of the anchoring
element mechanisms - Radio-opaque materials suitable for coating onto an expandable surface include, for example, barium, tungsten, bismuth, tantalum, and tin. As an alternative to coating the anchoring elements and/or the centering mechanisms with a radio-opaque material, a radiation-blocking or absorbing shield (not shown) can be positioned between each anchoring element and the centering mechanisms disposed therein, or within the centering mechanisms to produce a desired isodose curve. A person having ordinary skill in the art will appreciate that other configurations may be employed to achieve the desired isodose curves and/or shielding of radiation sensitive tissue. In particular with the present invention, longitudinal shielding could be provided between the radiation source and the patient's spinal cord in order to treat cancerous tissue in and around the spine while protecting the spinal cord from radiation.
- In yet another embodiment, the radiation source itself can be configured to provide radiation to a desired region of tissue surrounding the interstitial space. By way of non-limiting example, the radiation source can comprise a wire having one or more solid radioactive particles located thereon. The radioactive source can either be preloaded into the catheter at the time of manufacture, or loaded into the device after it has been implanted into the space formerly occupied by the excised tumor. If loaded after implantation, the solid radiation emitting material can be inserted through one of the
lumens catheter 40 may need to be adapted to have a size sufficient to receive such a radiation source. The radiation source has an asymmetric configuration with respect to a longitudinal axis of the instrument. That is, radiation source is shaped so as to result in an isodose profile that varies radially about the longitudinal axis A. The asymmetrically shaped isodose curve may be created by providing a plurality of solid radioactive particles on a curved wire in a spaced apart relationship. This configuration will result in certain of the solid radioactive particles being farther from the longitudinal axis of the instrument than others, and will result in the illustrated asymmetric isodose profile. - One way to provide the radioactive source configuration is to form wire from a solid or tubular shape memory alloy such as nickel-titanium alloys known in the art to have such properties. Wire can then be preformed to the desired shape, can be compressed into a substantially straight configuration to pass through the first lumen, and will resume its desired shape once inside volume where wire will be free from steric constraints imposed inside the first lumen. The resulting asymmetric isodose curve can be further tailored by using solid radioactive particles having differing specific activities to achieve the desired dosing. Such a configuration is described in more detail in U.S. Pat. No. 6,482,142, issued on Nov. 19, 2002, and entitled “Asymmetric Radiation Dosing Apparatus and Method.”
- A person having ordinary skill in the art will appreciate that the foregoing is only illustrative of the principles of the invention, and that various modifications can be made by those skilled in the art without departing from the scope and spirit of the invention. All references cited herein are expressly incorporated by reference in their entirety.
Claims (43)
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US13/286,920 US20120116146A1 (en) | 2003-02-13 | 2011-11-01 | Multi-lumen instrument for providing radiation to a body cavity |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060100475A1 (en) * | 2004-11-05 | 2006-05-11 | White Jack C | Expandable brachytherapy device |
US20070142694A1 (en) * | 2005-12-16 | 2007-06-21 | North American Scientific | Brachytherapy apparatus |
US20070270627A1 (en) * | 2005-12-16 | 2007-11-22 | North American Scientific | Brachytherapy apparatus for asymmetrical body cavities |
US20080027265A1 (en) * | 2006-07-25 | 2008-01-31 | Ams Research Corporation | Shielded High Dose Radiation Catheters |
US20080146862A1 (en) * | 2006-04-21 | 2008-06-19 | North American Scientific, Inc. | Brachytherapy Device Having Seed Tubes With Individually-Settable Tissue Spacings |
US20110015741A1 (en) * | 2009-07-16 | 2011-01-20 | Warsaw Orthopedic, Inc. | Spinal implant configured to apply radiation treatment and method |
US20120078029A1 (en) * | 2010-09-23 | 2012-03-29 | Best Medical International | Rectal Catheter for Urological & Other Applications |
US8317673B2 (en) | 2010-04-30 | 2012-11-27 | Warsaw Othopedic, Inc. | Device and method for controlling emission of radiation |
US20170028174A1 (en) * | 2010-09-23 | 2017-02-02 | Best Medical International, Inc. | Multi-purpose balloon catheter for intra cavity radiation delivery |
US10589071B2 (en) | 2010-09-23 | 2020-03-17 | Best Medical International, Inc. | Multiple function balloon catheter |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050131267A1 (en) * | 1995-06-07 | 2005-06-16 | Talmadge Karen D. | System and method for delivering a therapeutic agent for bone disease |
US20050131268A1 (en) * | 1995-06-07 | 2005-06-16 | Talmadge Karen D. | System and method for delivering a therapeutic agent for bone disease |
US20050131269A1 (en) * | 1995-06-07 | 2005-06-16 | Talmadge Karen D. | System and method for delivering a therapeutic agent for bone disease |
US6695760B1 (en) * | 2002-10-11 | 2004-02-24 | Proxima Therapeutics | Treatment of spinal metastases |
US7815561B2 (en) * | 2003-09-25 | 2010-10-19 | Xoft, Inc. | Brachytherapy applicator |
US7905822B2 (en) | 2003-11-20 | 2011-03-15 | Cytyc Corporation | Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region |
BRPI0515007A (en) | 2004-08-12 | 2008-07-01 | Navotek Medical Ltd | computerized system for tracking and tracing of irradiated ionization source, sensor for targeting located on an ionized radiation source, method for determining device location, method of locating device manufacturing, and use of ionizing radiation shield |
US7516399B2 (en) * | 2004-09-30 | 2009-04-07 | Microsoft Corporation | Structured-document path-language expression methods and systems |
US20080262473A1 (en) * | 2004-10-19 | 2008-10-23 | Navotek Medical Ltd. | Locating a Catheter Tip Using a Tracked Guide |
US20060264896A1 (en) * | 2005-05-09 | 2006-11-23 | Palmer Erika I | Minimally invasive apparatus and method for treatment of a tumor associated with a bone |
BRPI0616514A2 (en) * | 2005-08-11 | 2011-06-21 | Navotek Medical Ltd | medical treatment system and method using position sensor based radioactivity |
CN101282760A (en) | 2005-08-11 | 2008-10-08 | 纳沃特克医药有限公司 | Medical treatment system and method using radioactivity based position sensor |
EP1922011B1 (en) * | 2005-08-11 | 2012-05-02 | Navotek Medical Ltd. | Localization of a radioactive source |
US8079946B2 (en) | 2005-11-18 | 2011-12-20 | Senorx, Inc. | Asymmetrical irradiation of a body cavity |
US20090209803A1 (en) * | 2008-02-14 | 2009-08-20 | Lovoi Paul A | Adjuvant brachytherapy apparatus and method for use with kyphoplasty |
EP2156806A1 (en) * | 2008-08-18 | 2010-02-24 | Navotek Medical Ltd. | Implantation device for soft tissue markers and other implants |
US20100137674A1 (en) * | 2008-11-26 | 2010-06-03 | David Evans | Brachytherapy treatment of the spine with irradiated implants |
US9248311B2 (en) | 2009-02-11 | 2016-02-02 | Hologic, Inc. | System and method for modifying a flexibility of a brachythereapy catheter |
US9579524B2 (en) | 2009-02-11 | 2017-02-28 | Hologic, Inc. | Flexible multi-lumen brachytherapy device |
US10207126B2 (en) | 2009-05-11 | 2019-02-19 | Cytyc Corporation | Lumen visualization and identification system for multi-lumen balloon catheter |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
US9352172B2 (en) | 2010-09-30 | 2016-05-31 | Hologic, Inc. | Using a guide member to facilitate brachytherapy device swap |
US10342992B2 (en) | 2011-01-06 | 2019-07-09 | Hologic, Inc. | Orienting a brachytherapy applicator |
Citations (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3324847A (en) * | 1964-06-01 | 1967-06-13 | Elias G Zoumboulis | Radioactive catheter |
US3872856A (en) * | 1971-06-09 | 1975-03-25 | Ralph S Clayton | Apparatus for treating the walls and floor of the pelvic cavity with radiation |
US4350169A (en) * | 1979-01-05 | 1982-09-21 | Medtronic, Inc. | Flexible tip stiffening stylet for use with body implantable lead |
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4706652A (en) * | 1985-12-30 | 1987-11-17 | Henry Ford Hospital | Temporary radiation therapy |
US4754745A (en) * | 1984-11-21 | 1988-07-05 | Horowitz Bruce S | Conformable sheet material for use in brachytherapy |
US4763642A (en) * | 1986-04-07 | 1988-08-16 | Horowitz Bruce S | Intracavitational brachytherapy |
US4821725A (en) * | 1985-06-07 | 1989-04-18 | C.G.R. Mev | Device for treatment through hyperthermia |
US4867741A (en) * | 1983-11-04 | 1989-09-19 | Portnoy Harold D | Physiological draining system with differential pressure and compensating valves |
US5015247A (en) * | 1988-06-13 | 1991-05-14 | Michelson Gary K | Threaded spinal implant |
US5084015A (en) * | 1988-05-16 | 1992-01-28 | Terumo Kabushiki Kaisha | Catheter assembly of the hypodermic embedment type |
US5084001A (en) * | 1986-07-10 | 1992-01-28 | Eric van't Hooft | Method and apparatus for effecting radioactive therapy in an animal body |
US5106360A (en) * | 1987-09-17 | 1992-04-21 | Olympus Optical Co., Ltd. | Thermotherapeutic apparatus |
US5112303A (en) * | 1991-05-02 | 1992-05-12 | Pudenz-Schulte Medical Research Corporation | Tumor access device and method for delivering medication into a body cavity |
US5152747A (en) * | 1989-08-16 | 1992-10-06 | Olivier Lucien C | Implantable reservoir and balloon catheter system |
US5236410A (en) * | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
US5422926A (en) * | 1990-09-05 | 1995-06-06 | Photoelectron Corporation | X-ray source with shaped radiation pattern |
US5484384A (en) * | 1991-01-29 | 1996-01-16 | Med Institute, Inc. | Minimally invasive medical device for providing a radiation treatment |
US5520646A (en) * | 1994-03-03 | 1996-05-28 | D'andrea; Mark A. | Diagnostic marking catheter system for use in radiation diagnosis procedure |
US5562594A (en) * | 1994-06-10 | 1996-10-08 | Duke University | Shielded mini-applicator system for radioactive source treatment of cancer of the uterine cervix |
US5566221A (en) * | 1994-07-12 | 1996-10-15 | Photoelectron Corporation | Apparatus for applying a predetermined x-radiation flux to an interior surface of a body cavity |
US5653683A (en) * | 1995-02-28 | 1997-08-05 | D'andrea; Mark A. | Intracavitary catheter for use in therapeutic radiation procedures |
US5724400A (en) * | 1992-03-19 | 1998-03-03 | Wisconsin Alumni Research Foundation | Radiation therapy system with constrained rotational freedom |
US5800333A (en) * | 1996-02-20 | 1998-09-01 | United States Surgical Corporation | Afterloader provided with remote control unit |
US5803895A (en) * | 1995-07-21 | 1998-09-08 | Huels Aktiengesellschaft | Flexible adaptable plastic elements with equidistantly embedded catheters for radiotherapy |
US5851182A (en) * | 1996-09-11 | 1998-12-22 | Sahadevan; Velayudhan | Megavoltage radiation therapy machine combined to diagnostic imaging devices for cost efficient conventional and 3D conformal radiation therapy with on-line Isodose port and diagnostic radiology |
US5863284A (en) * | 1995-11-13 | 1999-01-26 | Localmed, Inc. | Devices and methods for radiation treatment of an internal body organ |
US6036631A (en) * | 1998-03-09 | 2000-03-14 | Urologix, Inc. | Device and method for intracavitary cancer treatment |
US6050930A (en) * | 1998-06-02 | 2000-04-18 | Teirstein; Paul S. | Irradiation catheter with expandable source |
US6234952B1 (en) * | 1996-09-13 | 2001-05-22 | Interventional Therapies Llc | Dilatation/centering catheter used for the treatment of stenosis or other construction in a bodily passageway and method thereof |
US6267775B1 (en) * | 1997-03-21 | 2001-07-31 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
US6306074B1 (en) * | 1994-10-27 | 2001-10-23 | Novoste Corporation | Method and apparatus for radiation treatment of a desired area in the vascular system of a patient |
US6413204B1 (en) * | 1997-07-24 | 2002-07-02 | Proxima Therapeutics, Inc. | Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases |
US6416457B1 (en) * | 2000-03-09 | 2002-07-09 | Scimed Life Systems, Inc. | System and method for intravascular ionizing tandem radiation therapy |
US6458070B1 (en) * | 1994-10-27 | 2002-10-01 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US6482142B1 (en) * | 1997-07-24 | 2002-11-19 | Proxima Therapeutics, Inc. | Asymmetric radiation dosing apparatus and method |
US6558390B2 (en) * | 2000-02-16 | 2003-05-06 | Axiamed, Inc. | Methods and apparatus for performing therapeutic procedures in the spine |
US20030153803A1 (en) * | 2000-06-07 | 2003-08-14 | Michael Harmon | Cervical applicator for high dose radiation brachytherapy |
US6607477B1 (en) * | 1998-02-16 | 2003-08-19 | Wallace A. Longton | Graduated intraluminal catheter and methods of use thereof |
US6616629B1 (en) * | 1994-06-24 | 2003-09-09 | Schneider (Europe) A.G. | Medical appliance with centering balloon |
US6685618B2 (en) * | 1998-02-19 | 2004-02-03 | Endologix, Inc. | Method for delivering radiation to an intraluminal site in the body |
US20060100475A1 (en) * | 2004-11-05 | 2006-05-11 | White Jack C | Expandable brachytherapy device |
US20070167666A1 (en) * | 2005-11-18 | 2007-07-19 | Senorx, Inc. | Asymmetrical irradiation of a body cavity |
US20070191667A1 (en) * | 2005-11-18 | 2007-08-16 | Senorx, Inc. | Methods for tissue irradiation with shielding |
US20070270627A1 (en) * | 2005-12-16 | 2007-11-22 | North American Scientific | Brachytherapy apparatus for asymmetrical body cavities |
US20080221384A1 (en) * | 2006-06-02 | 2008-09-11 | Cianna Medical, Inc. | Expandable brachytherapy apparatus and methods for using them |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456000A (en) * | 1981-08-17 | 1984-06-26 | Angiomedics Corporation | Expandable occlusion apparatus |
NL8400108A (en) | 1984-01-12 | 1985-08-01 | Hooft Eric T | METHOD AND APPARATUS FOR TREATING A BODY PART WITH RADIOACTIVE MATERIAL |
WO1992010932A1 (en) | 1990-12-17 | 1992-07-09 | Microwave Medical Systems, Inc. | Therapeutic probe for radiating microwave and nuclear radiation |
IT1251997B (en) | 1991-11-11 | 1995-05-27 | San Romanello Centro Fond | RADIANT DEVICE FOR HYPERTHERMIA |
US6217503B1 (en) | 1994-01-21 | 2001-04-17 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to treat a disease process in a luminal structure |
US6033357A (en) | 1997-03-28 | 2000-03-07 | Navius Corporation | Intravascular radiation delivery device |
AT407009B (en) | 1997-09-01 | 2000-11-27 | Ali Dr Hassan | CATHETER DEVICE FOR RADIOACTIVE TREATMENT OF BODY CAVES |
JP2001526946A (en) | 1997-12-31 | 2001-12-25 | クック インコーポレイティド | Radioactive gas injection device |
US6540734B1 (en) * | 2000-02-16 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Multi-lumen extrusion tubing |
-
2003
- 2003-02-13 US US10/365,977 patent/US6749555B1/en not_active Expired - Lifetime
-
2004
- 2004-06-14 US US10/867,062 patent/US20050027157A1/en not_active Abandoned
-
2011
- 2011-11-01 US US13/286,920 patent/US20120116146A1/en not_active Abandoned
Patent Citations (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3324847A (en) * | 1964-06-01 | 1967-06-13 | Elias G Zoumboulis | Radioactive catheter |
US3872856A (en) * | 1971-06-09 | 1975-03-25 | Ralph S Clayton | Apparatus for treating the walls and floor of the pelvic cavity with radiation |
US4350169A (en) * | 1979-01-05 | 1982-09-21 | Medtronic, Inc. | Flexible tip stiffening stylet for use with body implantable lead |
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4867741A (en) * | 1983-11-04 | 1989-09-19 | Portnoy Harold D | Physiological draining system with differential pressure and compensating valves |
US4754745A (en) * | 1984-11-21 | 1988-07-05 | Horowitz Bruce S | Conformable sheet material for use in brachytherapy |
US4821725A (en) * | 1985-06-07 | 1989-04-18 | C.G.R. Mev | Device for treatment through hyperthermia |
US4706652A (en) * | 1985-12-30 | 1987-11-17 | Henry Ford Hospital | Temporary radiation therapy |
US4763642A (en) * | 1986-04-07 | 1988-08-16 | Horowitz Bruce S | Intracavitational brachytherapy |
US5084001A (en) * | 1986-07-10 | 1992-01-28 | Eric van't Hooft | Method and apparatus for effecting radioactive therapy in an animal body |
US5106360A (en) * | 1987-09-17 | 1992-04-21 | Olympus Optical Co., Ltd. | Thermotherapeutic apparatus |
US5084015A (en) * | 1988-05-16 | 1992-01-28 | Terumo Kabushiki Kaisha | Catheter assembly of the hypodermic embedment type |
US5741253A (en) * | 1988-06-13 | 1998-04-21 | Michelson; Gary Karlin | Method for inserting spinal implants |
US5015247A (en) * | 1988-06-13 | 1991-05-14 | Michelson Gary K | Threaded spinal implant |
US5152747A (en) * | 1989-08-16 | 1992-10-06 | Olivier Lucien C | Implantable reservoir and balloon catheter system |
US5236410A (en) * | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
US5422926A (en) * | 1990-09-05 | 1995-06-06 | Photoelectron Corporation | X-ray source with shaped radiation pattern |
US5484384A (en) * | 1991-01-29 | 1996-01-16 | Med Institute, Inc. | Minimally invasive medical device for providing a radiation treatment |
US5112303A (en) * | 1991-05-02 | 1992-05-12 | Pudenz-Schulte Medical Research Corporation | Tumor access device and method for delivering medication into a body cavity |
US5724400A (en) * | 1992-03-19 | 1998-03-03 | Wisconsin Alumni Research Foundation | Radiation therapy system with constrained rotational freedom |
US5520646A (en) * | 1994-03-03 | 1996-05-28 | D'andrea; Mark A. | Diagnostic marking catheter system for use in radiation diagnosis procedure |
US5562594A (en) * | 1994-06-10 | 1996-10-08 | Duke University | Shielded mini-applicator system for radioactive source treatment of cancer of the uterine cervix |
US6616629B1 (en) * | 1994-06-24 | 2003-09-09 | Schneider (Europe) A.G. | Medical appliance with centering balloon |
US5566221A (en) * | 1994-07-12 | 1996-10-15 | Photoelectron Corporation | Apparatus for applying a predetermined x-radiation flux to an interior surface of a body cavity |
US6458070B1 (en) * | 1994-10-27 | 2002-10-01 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US6306074B1 (en) * | 1994-10-27 | 2001-10-23 | Novoste Corporation | Method and apparatus for radiation treatment of a desired area in the vascular system of a patient |
US5720717A (en) * | 1995-02-28 | 1998-02-24 | D'andrea; Mark A. | Intracavitary catheter for use in therapeutic radiation procedures |
US5653683A (en) * | 1995-02-28 | 1997-08-05 | D'andrea; Mark A. | Intracavitary catheter for use in therapeutic radiation procedures |
US5803895A (en) * | 1995-07-21 | 1998-09-08 | Huels Aktiengesellschaft | Flexible adaptable plastic elements with equidistantly embedded catheters for radiotherapy |
US5863284A (en) * | 1995-11-13 | 1999-01-26 | Localmed, Inc. | Devices and methods for radiation treatment of an internal body organ |
US5800333A (en) * | 1996-02-20 | 1998-09-01 | United States Surgical Corporation | Afterloader provided with remote control unit |
US5851182A (en) * | 1996-09-11 | 1998-12-22 | Sahadevan; Velayudhan | Megavoltage radiation therapy machine combined to diagnostic imaging devices for cost efficient conventional and 3D conformal radiation therapy with on-line Isodose port and diagnostic radiology |
US6234952B1 (en) * | 1996-09-13 | 2001-05-22 | Interventional Therapies Llc | Dilatation/centering catheter used for the treatment of stenosis or other construction in a bodily passageway and method thereof |
US6267775B1 (en) * | 1997-03-21 | 2001-07-31 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
US6482142B1 (en) * | 1997-07-24 | 2002-11-19 | Proxima Therapeutics, Inc. | Asymmetric radiation dosing apparatus and method |
US6413204B1 (en) * | 1997-07-24 | 2002-07-02 | Proxima Therapeutics, Inc. | Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases |
US6607477B1 (en) * | 1998-02-16 | 2003-08-19 | Wallace A. Longton | Graduated intraluminal catheter and methods of use thereof |
US6685618B2 (en) * | 1998-02-19 | 2004-02-03 | Endologix, Inc. | Method for delivering radiation to an intraluminal site in the body |
US6036631A (en) * | 1998-03-09 | 2000-03-14 | Urologix, Inc. | Device and method for intracavitary cancer treatment |
US6050930A (en) * | 1998-06-02 | 2000-04-18 | Teirstein; Paul S. | Irradiation catheter with expandable source |
US6558390B2 (en) * | 2000-02-16 | 2003-05-06 | Axiamed, Inc. | Methods and apparatus for performing therapeutic procedures in the spine |
US6416457B1 (en) * | 2000-03-09 | 2002-07-09 | Scimed Life Systems, Inc. | System and method for intravascular ionizing tandem radiation therapy |
US20030153803A1 (en) * | 2000-06-07 | 2003-08-14 | Michael Harmon | Cervical applicator for high dose radiation brachytherapy |
US20060100475A1 (en) * | 2004-11-05 | 2006-05-11 | White Jack C | Expandable brachytherapy device |
US20070167666A1 (en) * | 2005-11-18 | 2007-07-19 | Senorx, Inc. | Asymmetrical irradiation of a body cavity |
US20070191667A1 (en) * | 2005-11-18 | 2007-08-16 | Senorx, Inc. | Methods for tissue irradiation with shielding |
US20070270627A1 (en) * | 2005-12-16 | 2007-11-22 | North American Scientific | Brachytherapy apparatus for asymmetrical body cavities |
US20080221384A1 (en) * | 2006-06-02 | 2008-09-11 | Cianna Medical, Inc. | Expandable brachytherapy apparatus and methods for using them |
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US20060100475A1 (en) * | 2004-11-05 | 2006-05-11 | White Jack C | Expandable brachytherapy device |
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US8137256B2 (en) | 2005-12-16 | 2012-03-20 | Portola Medical, Inc. | Brachytherapy apparatus |
US20070270627A1 (en) * | 2005-12-16 | 2007-11-22 | North American Scientific | Brachytherapy apparatus for asymmetrical body cavities |
US7862497B2 (en) | 2006-04-21 | 2011-01-04 | Portola Medical, Inc. | Brachytherapy device having seed tubes with individually-settable tissue spacings |
US20080146862A1 (en) * | 2006-04-21 | 2008-06-19 | North American Scientific, Inc. | Brachytherapy Device Having Seed Tubes With Individually-Settable Tissue Spacings |
US20080027265A1 (en) * | 2006-07-25 | 2008-01-31 | Ams Research Corporation | Shielded High Dose Radiation Catheters |
US8454488B2 (en) * | 2006-07-25 | 2013-06-04 | Ams Research Corporation | Shielded high dose radiation catheters |
US20110015741A1 (en) * | 2009-07-16 | 2011-01-20 | Warsaw Orthopedic, Inc. | Spinal implant configured to apply radiation treatment and method |
US8317673B2 (en) | 2010-04-30 | 2012-11-27 | Warsaw Othopedic, Inc. | Device and method for controlling emission of radiation |
US10406381B2 (en) | 2010-09-23 | 2019-09-10 | Best Medical International, Inc. | Multi-balloon catheter for medical applications |
US9402980B2 (en) * | 2010-09-23 | 2016-08-02 | Best Medical International, Inc. | Rectal catheter for urological and other applications |
US20170028174A1 (en) * | 2010-09-23 | 2017-02-02 | Best Medical International, Inc. | Multi-purpose balloon catheter for intra cavity radiation delivery |
US20120078029A1 (en) * | 2010-09-23 | 2012-03-29 | Best Medical International | Rectal Catheter for Urological & Other Applications |
US10589071B2 (en) | 2010-09-23 | 2020-03-17 | Best Medical International, Inc. | Multiple function balloon catheter |
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US11511087B2 (en) | 2010-09-23 | 2022-11-29 | Best Medical International, Inc. | Dual double balloon catheter |
US11633576B2 (en) * | 2010-09-23 | 2023-04-25 | Best Medical International, Inc. | Multi-purpose balloon catheter for intra cavity radiation delivery |
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