US20040242627A1

US20040242627A1 - 2-Iminoimidazole derivatives (1)

Info

Publication number: US20040242627A1
Application number: US10/475,045
Authority: US
Inventors: Shuichi Suzuki; Makoto Kotake; Mitsuaki Miyamoto; Tetsuya Kawahara; Akiharu Kajiwara; Ieharu Hishinuma; Kazuo Okano; Syuhei Miyazawa; Richard Clark; Fumihiro Ozaki; Nobuaki Sato; Masanobu Shinoda; Atsushi Kamada; Itaru Tsukada; Fumiyoshi Matsuura; Yoshimitsu Naoe; Taro Terauchi; Yoshiaki Oohashi; Osamu Ito; Hiroshi Tanaka
Original assignee: Eisai Co Ltd
Current assignee: Eisai R&D Management Co Ltd
Priority date: 2001-04-19
Filing date: 2002-04-19
Publication date: 2004-12-02
Also published as: NO327849B1; ES2462995T3; CN100402499C; JP4464928B2; WO2002088092A1; CZ20032824A3; WO2002085855A1; RU2270192C2; IL158491A0; HUP0400467A2; IL158491A; EP1391456B1; JP3795458B2; EP1386912B1; JP4445201B2; JPWO2002085850A1; EP1394152A1; EP1614680A2; JPWO2002085855A1; AU2002255269B2

Abstract

A 2-iminoimidazole derivative represented by the formula:

{wherein ring C represents a benzene ring, a pyridine ring, etc.; R¹represents optionally substituted C_1-6alkyl, etc.; R²⁰¹represents hydrogen, halogen, acyl, etc.; R⁶represents hydrogen, C_1-6alkyl, C_1-6alkyloxycarbonyl, etc.; Y¹represents a single bond, —CH₂—, etc.; Y²represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula:

[wherein R¹⁰-R¹⁴represent hydrogen, C_1-6alkyl, hydroxyl, C_1-6alkoxy, etc., and R¹¹and R¹²or R¹²and R¹³may bond together to form a 5- to 8-membered heterocycle], etc.} or salt thereof.

Description

PRIORITY INFORMATION

The present application claims the benefit under 35 U.S.C. § 371 of International Application No.: PCT/JP02/03952 (published PCT application No. WO 02/088094), filed 19 Apr. 2002, which claims priority to Japanese Patent Application Nos.: 2001-121829, filed 19 Apr. 2001, and 2001-269422, filed 5 Sep. 2001, the entire contents of each of these applications are hereby incorporated herein by reference.

BACKGROUND OF THE INVENTION

A recent approach for thrombosis has involved inhibiting thrombin enzyme activity, and compounds used for this purpose have included heparin, low molecular weight heparin, hirudin, argatroban, hirulog and the like. All such compounds inhibit the enzyme activity of thrombin, and work by inhibiting fibrin blood clot formation without specifically inhibiting the effect of thrombin on cells. Bleeding tendency is therefore a common side effect encountered in the clinic. The role of thrombin in thrombosis is not limited to its blood clotting activity, as it is believed to also participate in platelet aggregation at sites of vascular injury occurring as a result of the activation of platelet thrombin receptor.

Another approach for thrombosis has been the use of intravenous injection agents such as Abciximab, Eptifibatide and Tirofiban, as GPIIb/IIIa receptor antagonists. These compounds, while exhibiting powerful anti-thrombotic effects by suppressing platelet aggregation induced by various stimulation such as thrombin, ADP, collagen, PAF or the like, also produce a bleeding tendency as a side effect similarly to thrombin enzyme activity inhibitors. For this reason, no such compounds have yet been marketed, although their development as oral agents continues to progress.

Restenosis is a vascular hyperproliferative response to vascular wall injury induced by invasive treatment such as coronary angioplasty, and this phenomenon may be provoked by the direct or indirect effect of thrombin on cells. Platelets adhere to injured blood vessels, leading to release of growth factors and eliciting proliferation of smooth muscle cells. Smooth muscle cells may also be affected indirectly by the action of thrombin on endothelial cells. Also, platelet adhesion occurs and procoagulant activity increases at sites of vascular injury. Smooth muscle cells can undergo further direct stimulation due to the high local thrombin concentration which is produced at such sites. While recent studies using the powerful thrombin inhibitor hirudin have suggested that thrombin induces cell proliferation during the process of restenosis, it has not yet been determined whether the thrombin effect is direct or indirect (Sarembock et al., Circulation 1992, 84: 232-243). Despite the implication of the cellular effects of thrombin in a variety of pathological symptoms, no therapeutically active substance is known which specifically blocks such effects.

The thrombin receptor (PAR1) has recently been cloned (Vu et al., Cell, 1991, 64: 1057-1068), opening an important door to development of substances which target cellular thrombin receptors. Detailed examination of the amino acid sequence of this thrombin receptor has revealed a thrombin binding site and hydrolysis site located in the 100 residue amino terminal domain of the receptor. Later research by amino acid mutation in the receptor has established that limited hydrolysis of this portion of the thrombin receptor by thrombin is necessary for receptor activation (Vu et al., Nature, 1991, 353: 674-677). A synthetic peptide corresponding to the amino acid sequence newly generated by hydrolysis of the thrombin receptor (the synthetic peptide is known as “thrombin receptor activating peptide”, or TRAP) can activate receptors which have not been hydrolyzed by thrombin. This suggests that the cleavage of the receptor, the new amino acid sequence generated at the amino terminal (known as the “tethered ligand peptide”) functions as the ligand and interacts with the distal binding site. Further studies of TRAP have confirmed homology of the thrombin receptors present in platelet, endothelial cell, fibroblast and smooth muscle cell (Hung et al., J. Cell. Biol. 1992, 116: 827-832; and Ngaiza, Jaffe, Biochem. Biophys. Res. Commun. 1991, 179: 1656-1661).

Research on the structure activity relationship of TRAP suggests that the pentapeptide Phe-Leu-Leu-Arg-Asn is a weak antagonist for platelet thrombin receptors activated by either thrombin or TRAP (Vassallo. et al., J. Biol. Chem., 1992, 267: 6081-6085(1992)). Different approaches to receptor antagonism have also been examined by other groups. One of these approaches has been an attempt to prepare antibodies for the thrombin binding domain of the thrombin receptor. Such antibodies specifically and effectively suppress activation of platelets by thrombin, and act as thrombin receptor antagonists (Hung et al., J. Clin. Invest. 1992, 89: 1350-1353). Another approach has been the development of peptide derivatives from TRAP (Steven M. S., J. Med. Chem. 1996, 39: 4879-4887; William J. H., Bioorg. Med. Chem. Lett. 1998, 8: 1649-1654; and David F. M., Bioorg. Med. Chem. Lett. 1999, 9: 255-260). Yet another approach has been the development of low molecular weight compounds discovered by high throughput screening using various assay systems such as receptor binding (Andrew W. S. et al., Bioorg. Med Chem. Lett. 1999, 9: 2073-2078; Scherig Plough WO99/26943; and Halord S. et al., ACS meeting in October 2001).

DETAILED DESCRIPTION OF CERTAIN PREFERRED EMBODIMENTS OF THE INVENTION

Compounds having antagonistic action on thrombin receptors are expected to exhibit excellent effects for therapy or prevention of diseases associated with thrombin, and therefore offer promise for effective therapy or prevention of, for example, thrombosis, vascular restenosis, deep venous thrombosis, pulmonary embolism, cerebral infarction, heart diseases, disseminated intravascular coagulation, hypertension, inflammatory diseases, rheumatism, asthma, glomerulonephritis, osteoporosis, neurological diseases, malignant tumors, and the like. It has been highly desired to provide thrombin receptor antagonists which are satisfactory in numerous aspects including pharmacological activity, thrombin receptor specificity, safety, dosage and oral efficacy. [0007]
However, the conventional thrombin receptor antagonists have been inadequate in terms of receptor specificity and oral efficacy. [0008]
It is therefore an object of the present invention to search for and discover compounds having excellent thrombin receptor inhibiting activity and being therefore useful as thrombin receptor antagonists. [0009]
The inventors have completed thorough research in light of such circumstances, leading to the synthesis of novel 2-iminoimidazole derivatives represented by the following general formula (I), the results of which have unexpectedly revealed that these compounds or salts thereof have excellent thrombin receptor-inhibiting activity and are useful as thrombin receptor antagonists, which culminated in the present invention. [0010]
<1> In one aspect, the present invention provides a compound represented by the formula: [0011]
{wherein ring C represents an optionally substituted aromatic hydrocarbon ring or pyridine ring; R[0012] ¹represents (1) hydrogen, (2) cyano, (3) halogen or (4) a group selected from Substituent Group A below; R²⁰¹represents (1) hydrogen or (2) a group selected from Substituent Group D below; R⁶represents (1) hydrogen, (2) C_1-6alkyl, (3) acyl, (4) carbamoyl, (5) hydroxyl, (6) C_1-6alkoxy, (7) C_1-6alkyloxycarbonyloxy, (8) C_3-8cycloalkyl, (9) C_1-6alkyloxycarbonyl optionally substituted with acyloxy or (10) a C_6-14aromatic hydrocarbon ring group or a 5- to 14-membered aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group E below); Y¹represents a single bond, —(CH₂)_m—, —CR⁸—, —CR⁸R⁹—, —CH₂CO—, —NR⁸—, —SO—, —SO₂—, —CO—, —CONR⁸— or —SO₂NR⁸— [wherein m represents an integer of 1 to 3, and R⁸and R⁹are the same or different and each independently represents hydrogen, halogen, C_1-6alkyl, carboxyl or C_1-6alkoxycarbonyl]; Y²represents a single bond, O, N, —(CH₂)_m—, —CR⁸—, CR⁸R⁹—, —CO—, —SO—, —SO₂— or —C(═N—OR⁸)— [wherein m, R⁸and R⁹have the same definitions given above]; and Ar represents (1) hydrogen, (2) a group represented by the formula:
[wherein R[0013] ¹⁰, R¹¹, R¹², R¹³and R¹⁴are the same or different and each independently represents (1) hydrogen, (2) cyano, (3) halogen, (4) nitro or (5) a group selected from Substituent Group B below, and R¹¹and R¹²or R¹²and R¹³may bond together to form a 5- to 8-membered heterocycle optionally having 1 to 4 hetero atoms selected from N, S and O and optionally substituted with at least one group selected from Substituent Group F below] or (3) a 5- to 14-membered aromatic heterocyclic group optionally substituted with at least one group selected from Substituent Group G below.
<Substituent Group A> represents moieties selected from the group consisting of C[0014] _1-6alkyl, alkylidene, C_2-6alkenyl, C_2-6alkynyl, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, sulfonylamino, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A′ below;
<Substituent Group A′> represents moieties selected from the group consisting of C[0015] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen, C_3-8cycloalkyl, a heterocyclic alkyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C_6-14aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C_1-6alkyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C_3-8cycloalkyl;
<Substituent Group B> represents moieties selected from the group consisting of C[0016] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C₁₆aminoalkyl, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group B′ below;
<Substituent Group B′> represents moieties selected from the group consisting of C[0017] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, oxo, cyano, C_1-6cyanoacyl, C_2-7acyl, C_1-6alkanoyl, benzoyl, aralkanoyl, C_1-6alkoxyalkylcarbonyl, C_1-6hydroxyalkylcarbonyl, carboxyl, C_1-6carboxyalkyl, C_1-6carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C_1-6alkoxycarbonyl, C_1-10alkoxycarbonyl-C_1-6alkyl, C_1-10alkoxycarbonyl-C_1-6alkyloxy, C_1-6monoalkylaminocarbonyl, C_2-6dialkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-10alkoxyalkyl, C_1-10aralkyloxyalkyl, C_1-6hydroxyalkyl, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, phenylsulfonylamino, C_1-6alkylsulfonyl, phenylsulfonyl, C_1-6monoalkylaminosulfonyl, C_2-6dialkylaminosulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group, a 5-to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C_6-14aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C₁₆aminoalkyl, C_1-6alkylamino, C_1-6dialkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl;
<Substituent Group D> represents moieties selected from the group consisting of cyano, halogen, C[0018] _2-8alkenyl, C_2-8alkynyl, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl and C_1-6alkyl optionally substituted with at least one group selected from Substituent Group D′ below;
<Substituent Group D′> represents moieties selected from the group consisting of carboxyl, carbamoyl, C[0019] _1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, sulfonylamino, sulfonyl, sulfamoyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group;
<Substituent Group E> represents moieties selected from the group consisting of C[0020] _1-6alkyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C_3-8cycloalkyl;
<Substituent Group F> represents moieties selected from the group consisting of (1) hydrogen, (2) cyano, (3) halogen, (4) oxo and (5) C[0021] _1-6alkyl, alkenyl, alkynyl, acyl, C_1-6alkanoyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, imino, C_1-6aminoalkyl, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5-to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F′ below);
<Substituent Group F′> represents moieties selected from the group consisting of C[0022] _1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, benzyloxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, C_1-6alkylsulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group;
<Substituent Group G> represents moieties selected from the group consisting of C[0023] _1-6alkyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, sulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl.} or salt thereof.
<2> In certain embodiments, the invention provides a compound according to <1> or salt thereof, wherein ring C represents a further optionally substituted benzene ring or a further optionally substituted pyridine ring; R[0024] ¹represents C_1-6alkyl, C_2-6alkenyl or C_1-6alkoxy, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A″ below:
<Substituent Group A″> represents moieties selected from the group consisting of C[0025] _1-6alkyl, acyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-6alkylamino, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C_6-14aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C_1-6alkyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, nitro, C_1-6alkylamino, acylamino, sulfonylamino and halogen; R²⁰¹represents a group selected from the group consisting of hydrogen, halogen, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, sulfonylamino and sulfamoyl; R⁶represents a group selected from the group consisting of hydrogen, C_1-6alkyl and C_1-6alkyloxycarbonyl optionally substituted with acyloxy; Y¹represents a single bond or —(CH₂)_m— [wherein m represents an integer of 1 to 3]; Y²represents a single bond or —CO—; and Ar represents hydrogen or a group represented by the formula:
[wherein R[0026] ¹⁰, R¹¹, R¹², R¹³and R¹⁴are the same or different and each independently represents a group selected from the group consisting of hydrogen, C_1-6alkyl, hydroxyl, C_1-6alkoxy, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, a 5- to 14-membered non-aromatic heterocyclic group and C_1-6alkyloxycarbonyloxy, wherein R¹¹and R¹²or R¹²and R¹³may bond together to form a 5- to 8-membered heterocycle (i) optionally having 1 to 4 hetero atoms selected from N, S and O and (ii) optionally substituted with at least one group selected from the group consisting of cyano, oxo, and C_1-6alkyl, acyl, C_1-6alkanoyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, sulfonyl and a 5- to 14-membered non-aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F″ below:
<Substituent Group F″> represents moieties selected from the group consisting of C[0027] _1-6alkyl, oxo, cyano, acyl, carboxyl and C_1-6alkoxy].
<3> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Y[0028] ¹is —CH₂—.
<4> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Y[0029] ²is —CO—.
<5> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Y[0030] ¹is —CH₂— and Y²is —CO—.
<6> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Y[0031] ¹is a single bond, Y²is a single bond and Ar is hydrogen.
<7> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Ar is a group represented by the formula: [0032]
[wherein R[0033] ¹⁰, R¹¹, R¹², R¹³and R¹⁴have the same definitions given above].
<8> In certain other embodiments, the invention provides a compound according to <7> or salt thereof, wherein R[0034] ¹⁰and R¹⁴are hydrogen.
<9> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Ar is (1) a group represented by the formula: [0035]
[wherein R[0036] ¹⁰, R¹¹, R¹², R¹³and R¹⁴have the same definitions given above] or (2) a 5- to 14-membered aromatic heterocyclic group optionally substituted with at least one group selected from Substituent Group G above.
<10> In certain other embodiments, the invention provides a compound according to <9> or salt thereof, wherein R[0037] ¹⁰and R¹⁴are hydrogen.
<11> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Ar is a group represented by the formula: [0038]
[wherein R[0039] ¹¹and R¹³have the same definitions given above, and R¹⁵represents (1) hydrogen or (2) a group selected from Substituent Group H below, and R¹¹and R¹⁵may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F above and optionally having 1 or 2 hetero atoms selected from N, S and O.
<Substituent Group H> represents moieties selected from the group consisting of C[0040] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, acyl, C_1-6alkoxycarbonyl, aminocarbonyl, C_1-6alkylaminocarbonyl, C_3-8cycloalkyl, C_1-6aminoalkyl, sulfonyl, C_3-8cycloalkylamino, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group H′ below;
<Substituent Group H′> represents moieties selected from the group consisting of C[0041] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, oxo, cyano, C_1-6cyanoalkyl, C_2-7acyl, C_1-6alkanoyl, benzoyl, aralkanoyl, C_1-6alkoxyalkylcarbonyl, C_1-6hydroxyalkylcarbonyl, carboxyl, C_1-6carboxyalkyl, C_1-6carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C_1-6alkoxycarbonyl, C_1-10alkoxycarbonyl-C_1-6alkyl, C_1-10alkoxycarbonyl-C_1-6alkyloxy, C_1-6monoalkylaminocarbonyl, C_2-6dialkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-10alkoxyalkyl, C_1-10aralkyloxyalkyl, C_1-6hydroxyalkyl, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, phenylsulfonylamino, C_1-6alkylsulfonyl, phenylsulfonyl, C_1-6monoalkylaminosulfonyl, C_2-6dialkylaminosulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group, a 5-to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C_6-14aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C₁₆aminoalkyl, C_1-6alkylamino, C_1-6dialkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl].
<12> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Ar is a group represented by the formula: [0042]
[wherein R[0043] ¹¹and R¹⁵have the same definitions given above, and R¹⁶represents (1) hydrogen or (2) a group selected from Substituent Group H above, and R¹¹and R¹⁵or R¹⁵and R¹⁶may bond together to form a 5- to 6-membered heterocycle optionally substituted with at least one group selected from Substituent Group F above and optionally having 1 or 2 hetero atoms selected from N, S and O].
<13> In certain other embodiments, the invention provides a compound according to <1> or salt thereof, wherein Ar is a group represented by the formula: [0044]
[wherein R[0045] ¹¹and R¹⁵have the same definitions given above, and R¹⁷and R¹⁸are the same or different and each independently represents (1) hydrogen or (2) a group selected from Substituent Group I below, and R¹¹and R¹⁵, R¹⁵and R¹⁷, R¹⁵and R¹⁸or R¹⁷and R¹⁸may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F above and optionally having 1 or 2 hetero atoms selected from N, S and O.
<Substituent Group I> represents moieties selected from the group consisting of C[0046] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, acyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, C₁₆aminoalkyl, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group I′ below;
<Substituent Group I′> represents moieties selected from the group consisting of C[0047] _1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, oxo, cyano, C_1-6cyanoalkyl, C_2-7acyl, C_1-6alkanoyl, benzoyl, aralkanoyl, C_1-6alkoxyalkylcarbonyl, C_1-6hydroxyalkylcarbonyl, carboxyl, C_1-6carboxyalkyl, C_1-6carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C_1-6alkoxycarbonyl, C_1-10alkoxycarbonyl-C_1-6alkyl, C_1-10alkoxycarbonyl-C_1-6alkyloxy, C_1-6monoalkylaminocarbonyl, C_2-6dialkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-10alkoxyalkyl, C_1-10aralkyloxyalkyl, C_1-6hydroxyalkyl, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, phenylsulfonylamino, C_1-6alkylsulfonyl, phenylsulfonyl, C_1-6monoalkylaminosulfonyl, C_2-6dialkylaminosulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group, a 5-to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C_6-14aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C_1-6aminoalkyl, C_1-6alkylamino, C_1-6dialkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl].
<14> In another aspect, the invention provides a pharmaceutical composition comprising a compound according to <1> or salt thereof. [0048]
<15> In certain embodiments, the invention provides a composition according to <14>, wherein the composition is useful as a thrombin receptor antagonist. [0049]
<16> In certain other embodiments, the invention provides a composition according to <14>, wherein the composition is useful as a thrombin receptor PAR1 antagonist. [0050]
<17> In certain other embodiments, the invention provides a composition according to <14>, wherein the composition is useful as a platelet aggregation inhibitor. [0051]
<18> In certain other embodiments, the invention provides a composition according to <14>, wherein the composition is useful as a proliferation inhibitor for smooth muscle cells. [0052]
<19> In certain other embodiments, the invention provides a composition according to <14>, wherein the composition is useful as a proliferation inhibitor for endothelial cells, fibroblasts, nephrocytes, osteosarcoma cells, muscle cells, cancer cells and/or glia cells. [0053]
<20> In certain other embodiments, the invention provides a composition according to <14>, wherein the composition is useful as a therapeutic or prophylactic agent for thrombosis, vascular restenosis, deep venous thrombosis, pulmonary embolism, cerebral infarction, heart disease, disseminated intravascular coagulation, hypertension, inflammatory disease, rheumatism, asthma, glomerulonephritis, osteoporosis, neurological disease and/or malignant tumor. [0054]
<21> In yet another aspect, the invention provides the use of a compound according to <1> or salt thereof for the manufacture of a thrombin receptor antagonist. [0055]
<22> In certain embodiments, the invention provides the use according to <21>, wherein the thrombin receptor antagonist is a PAR1 receptor antagonist. [0056]
<23> In certain other embodiments, the invention provides the use of a compound according to <1> or salt thereof for the manufacture of a platelet aggregation inhibitor. [0057]
<24> In a further aspect, the invention provides a therapeutic method for treating or preventing a disease associated with thrombin receptors, comprising administering to a patient suffering from the disease, a therapeutically effective dose of a compound according to <1> or salt thereof. [0058]
<25> In certain embodiments, the invention provides a therapeutic method for treating or preventing a proliferative disease of endothelial cells, fibroblasts, nephrocytes, osteosarcoma cells, muscle cells, cancer cells and/or glia cells, comprising administering to a patient suffering from the disease, a therapeutically effective dose of a compound according to <1> or salt thereof. [0059]
The present invention will now be explained in greater detail. [0060]
Several of the structural formulas given for the compounds of the invention throughout the present specification will represent only a specific isomer for convenience, but the invention is not limited to such specific isomers and encompasses all isomers and isomer mixtures, including geometric isomers, asymmetric carbon-derived optical isomers, stereoisomers and tautomers which are implied by the structures of the compounds, and any isomer or mixture thereof may be used. The compounds of the invention therefore include those having asymmetric carbons in their molecules and existing as optically active forms or racemic forms, and all such compounds are encompassed by the invention without restrictions. There are also no restrictions on any crystalline polymorphism of the compounds, and any crystal forms may be used alone or in mixtures. The compounds of the invention and their salts may also be in the form of anhydrides or solvates such as hydrates, and all such forms are included within the scope of the claims of the present specification. Metabolites of the compounds of the invention produced by degradation in the body, as well as prodrugs of the compounds of the invention and their salts, are also encompassed within the scope of the claims of the present specification. [0061]
The symbols and terms used throughout the present specification will now be defined, with a more detailed description of the invention. [0062]
The term “and/or” as used throughout the present specification carries the meaning of both “and” and “or”. [0063]
The term “halogen” used throughout the present specification refers to an atom such as fluorine, chlorine, bromine or iodine, and preferably fluorine, chlorine or bromine. [0064]
The term “C[0065] _1-6alkyl” used throughout the present specification refers to an alkyl group of 1 to 6 carbons, such as, for example, linear or branched alkyl groups such as methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, tert-butyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 2-ethylpropyl, n-hexyl, 1-methyl-2-ethylpropyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1-propylpropyl, 1-methylbutyl, 2-methylbutyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl and 3-methylpentyl, and more preferably methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, tert-butyl and n-pentyl.
The term “C[0066] _2-6alkenyl” used throughout the present specification refers to an alkenyl group of 2 to 6 carbons, such as, for example, vinyl, allyl, 1-propenyl, 2-propenyl, isopropenyl, 2-methyl-1-propenyl, 3-methyl-1-propenyl, 2-methyl-2-propenyl, 3-methyl-2-propenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-pentenyl, 1-hexenyl, 1,3-hexanedienyl and 1,6-hexanedienyl.
The term “C[0067] _2-6alkynyl” used throughout the present specification refers to an alkynyl group of 2 to 6 carbons, such as, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 3-methyl-1-propynyl, 1-ethynyl-2-propynyl, 2-methyl-3-propynyl, 1-pentynyl, 1-hexynyl, 1,3-hexanediynyl and 1,6-hexanediynyl.
The term “C[0068] _3-8cycloalkyl” used throughout the present specification refers to a cycloalkyl group composed of 3 to 8 carbons, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
The term “C[0069] _3-8cycloalkenyl” used throughout the present specification refers to a C_3-8cycloalkenyl group composed of 3 to 8 carbons, such as, for example, cyclopropen-1-yl, cyclopropen-3-yl, cyclobuten-1-yl, cyclobuten-3-yl, 1,3-cyclobutadien-1-yl, cyclopenten-1-yl, cyclopenten-3-yl, cyclopenten-4-yl, 1,3-cyclopentadien-1-yl, 1,3-cyclopentadien-2-yl, 1,3-cyclopentadien-5-yl, cyclohexen-1-yl, cyclohexen-3-yl, cyclohexen-4-yl, 1,3-cyclohexadien-1-yl, 1,3-cyclohexadien-2-yl, 1,3-cyclohexadien-5-yl, 1,4-cyclohexadien-3-yl, 1,4-cyclohexadien-1-yl, cyclohepten-1-yl, cyclohepten-3-yl, cyclohepten-4-yl, cyclohepten-5-yl, 1,3-cyclohepten-2-yl, 1,3-cyclohepten-1-yl, 1,3-cycloheptadien-5-yl, 1,3-cycloheptadien-6-yl, 1,4-cycloheptadien-3-yl, 1,4-cycloheptadien-2-yl, 1,4-cycloheptadien-1-yl, 1,4-cycloheptadien-6-yl, 1,3,5-cycloheptatrien-3-yl, 1,3,5-cycloheptatrien-2-yl, 1,3,5-cycloheptatrien-1-yl, 1,3,5-cycloheptatrien-7-yl, cycloocten-1-yl, cycloocten-3-yl, cycloocten-4-yl, cycloocten-5-yl, 1,3-cyclooctadien-2-yl, 1,3-cyclooctadien-1-yl, 1,3-cyclooctadien-5-yl, 1,3-cyclooctadien-6-yl, 1,4-cyclooctadien-3-yl, 1,4-cyclooctadien-2-yl, 1,4-cyclooctadien-1-yl, 1,4-cyclooctadien-6-yl, 1,4-cyclooctadien-7-yl, 1,5-cyclooctadien-3-yl, 1,5-cyclooctadien-2-yl, 1,3,5-cyclooctatrien-3-yl, 1,3,5-cyclooctatrien-2-yl, 1,3,5-cyclooctatrien-1-yl, 1,3,5-cyclooctatrien-7-yl, 1,3,6-cyclooctatrien-2-yl, 1,3,6-cyclooctatrien-1-yl, 1,3,6-cyclooctatrien-5-yl and 1,3,6-cyclooctatrien-6-yl.
The term “C[0070] _1-6alkoxy” used throughout the present specification refers to an alkoxy group of 1 to 6 carbons, such as, for example, methoxy, ethoxy, n-propoxy, iso-propoxy, sec-propoxy, n-butoxy, iso-butoxy, sec-butoxy, tert-butoxy, n-pentyloxy, iso-pentyloxy, sec-pentyloxy, n-hexoxy, iso-hexoxy, 1,1-dimethylpropyloxy, 1,2-dimethylpropoxy, 2,2-dimethylpropyloxy, 2-ethylpropoxy, 1-methyl-2-ethylpropoxy, 1-ethyl-2-methylpropoxy, 1,1,2-trimethylpropoxy, 1,1,2-trimethylpropoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2-ethylbutoxy, 1,3-dimethylbutoxy, 2-methylpentoxy, 3-methylpentoxy and hexyloxy.
The term “C[0071] _2-6alkenyloxy” used throughout the present specification refers to an alkenyloxy group of 2 to 6 carbons, such as, for example, vinyloxy, allyloxy, 1-propenyloxy, 2-propenyloxy, isopropenyloxy, 2-methyl-1-propenyloxy, 3-methyl-1-propenyloxy, 2-methyl-2-propenyloxy, 3-methyl-2-propenyloxy, 1-butenyloxy, 2-butenyloxy, 3-butenyloxy, 1-pentenyloxy, 1-hexenyloxy, 1,3-hexanedienyloxy and 1,6-hexanedienyloxy.
The term “acyl” used throughout the present specification refers to an atomic group derived by removing the OH group from a carboxyl group of a carboxylic acid, and it is preferably a C[0072] _2-7acyl group (an atomic group derived by removing the OH group from a carboxyl group of a C_2-7carboxylic acid (more preferably fatty acid)), of which examples include acetyl, propionyl, butyroyl and benzoyl.
The term “C[0073] _6-14aromatic hydrocarbon ring group” used throughout the present specification refers to an aromatic hydrocarbon ring group composed of 6 to 14 carbons, and includes monocyclic groups as well as fused rings such as bicyclic and tricyclic groups. Examples include phenyl, indenyl, 1-naphthyl, 2-naphthyl, azulenyl, heptalenyl, biphenyl, indacenyl, acenaphthyl, fluorenyl, phenalenyl, phenanthrenyl, anthracenyl, cyclopentacyclooctenyl and benzocyclooctenyl.
The term “5- to 14-membered aromatic heterocyclic group” used throughout the present specification refers to a monocyclic, bicyclic or tricyclic 5- to 14-membered aromatic heterocyclic group comprising one or more hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen. Examples include (i) nitrogen-containing aromatic heterocyclic groups such as pyrrolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazolyl, tetrazolyl, benzotriazolyl, pyrazolyl, imidazolyl, benzimidazolyl, indolyl, isoindolyl, indolidinyl, purinyl, indazolyl, quinolyl, isoquinolyl, quinolidyl, phthalazyl, naphthylidinyl, quinoxalyl, quinazolinyl, cinnolinyl, pteridinyl, imidazotriazinyl, pyrazinopyridazinyl, acridinyl, phenanthridinyl, carbazolyl, carbazolinyl, perimidinyl, phenanthrolinyl, phenacenyl, imidazopyridinyl, imidazopyrimidinyl, pyrazolopyridinyl, pyrazolopyridinyl, etc.; (ii) sulfur-containing aromatic heterocyclic groups such as thienyl, benzothienyl, etc.; (iii) oxygen-containing aromatic heterocyclic groups such as furyl, pyranyl, cyclopentapyranyl, benzofuryl, isobenzofuryl, etc.; and (iv) aromatic heterocyclic groups containing 2 or more different hetero atoms, such as thiazolyl, isothiazolyl, benzothiazolyl, benzothiadiazolyl, phenothiazinyl, isoxazolyl, furazanyl, phenoxazinyl, oxazolyl, isoxazoyl, benzoxazolyl, oxadiazolyl, pyrazoloxazolyl, imidazothiazolyl, thienofuranyl, furopyrrolyl, pyridoxazinyl, etc. [0074]
The term “5- to 14-membered non-aromatic heterocyclic group” used throughout the present specification refers to a monocyclic, bicyclic or tricyclic 5- to 14-membered non-aromatic heterocyclic group comprising one or more hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen. Examples include pyrrolidyl, pyrrolyl, piperidyl, piperazyl, imidazolyl, pyrazolidyl, imidazolidyl, morpholyl, tetrahydrofuryl, tetrahydropyranyl, aziridinyl, oxiranyl and oxathiolanyl. Non-aromatic heterocyclic groups also include a pyridone ring-derived group, and a non-aromatic fused ring (for example, a phthalimide ring-derived group and a succinimide ring-derived group). [0075]
The term “5- to 8-membered heterocycle” used throughout the present specification refers to a 5- to 8-membered aromatic or non-aromatic heterocycle. [0076]
The term “aryl” used throughout the present specification refers to an atomic group remaining after elimination of one hydrogen atom bonded to the ring of the aromatic hydrocarbon. Examples include phenyl, tolyl, xylyl, biphenyl, naphthyl, anthoryl and phenanthoryl. [0077]
The term “alkylidene” used throughout the present specification refers to a divalent group derived by the loss of two hydrogen atoms from the same carbon of an aliphatic hydrocarbon (preferably a C[0078] _1-6alkane). Examples include ethylidene and the like.
The expression “optionally substituted” appearing throughout the present specification has the same meaning as “having one or multiple substituents in any desired combination at substitutable positions”. [0079]
The term “hetero atom” used throughout the present specification refers specifically to oxygen, sulfur, nitrogen, phosphorus, arsenic, antimony, silicon, germanium, tin, lead, boron, mercury and the like, and preferably oxygen, sulfur and nitrogen. [0080]
Throughout the present specification, the prefix “n-” signifies a normal type or primary substituent, “sec-” signifies a secondary substituent, “t-” signifies a tertiary substituent and “i-” signifies an iso type substituent. [0081]
The definitions of ring C, R[0082] ¹, R²⁰¹, R⁶, Y¹, Y², and Ar in the compounds of the invention represented by general formula (I) above are as explained above. In certain exemplary embodiments,_ring C is preferably a benzene ring or pyridine ring optionally having an additional substituent (R²⁰¹), with benzene being more preferred. The position of the substituent (R²⁰¹) is not particularly restricted, but it is preferably the 5- or 6-position from the nitrogen atom to which Y¹is connected.
In certain embodiments, R[0083] ²⁰¹is a group selected from the group consisting of hydrogen, halogen, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, sulfonylamino and sulfamoyl.
In certain other embodiments, R[0084] ¹is (i) C_1-6alkyl, (ii) C_2-6alkenyl or (iii) C_1-6alkoxy, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A″ below, with (i) being more preferred:
<Substituent Group A″> represents moieties selected from the group consisting of C[0085] _1-6alkyl, acyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-6alkylamino, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C_6-14aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C_1-6alkyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, nitro, C_1-6alkylamino, acylamino, sulfonylamino and halogen.
In certain embodiments, R[0086] ⁶is a group selected from the group consisting of hydrogen, C_1-6alkyl and C_1-6alkyloxycarbonyl optionally substituted with acyloxy.
In certain embodiments, Y[0087] ¹is a single bond or —(CH₂)_m— [wherein m represents an integer of 1 to 3] and Y²is a single bond or —CO—, there being more preferred (i) the combination that Y¹is —CH₂— and Y²is —CO—, and (ii) the combination that Y¹and Y²are each a single bond.
In certain embodiments, Ar is hydrogen or a group represented by the formula: [0088]
[wherein R[0089] ¹⁰, R¹¹, R¹², R¹³and R¹⁴have the same definitions given above].
(i) When Y[0090] ¹is —CH₂— and Y²is —CO—, Ar is preferably a group represented by general formula (II) above, and (ii) when Y¹and Y²are each a single bond, Ar is preferably hydrogen.
R[0091] ¹⁰, R¹¹, R¹², R¹³and R¹⁴are the same or different and are each preferably a group selected from the group consisting of hydrogen, C_1-6alkyl, hydroxyl, C_1-6alkoxy, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, a 5- to 14-membered non-aromatic heterocyclic group and C_1-6alkyloxycarbonyloxy, and more preferably R¹⁰and R¹⁴are each hydrogen. Also, R¹¹and R¹²or R¹²and R¹³may bond together to form a 5- to 8-membered heterocyclic ring (i) optionally having 1 to 4 hetero atoms selected from N, S and O and (ii) optionally substituted with at least one group selected from the group consisting of cyano, oxo, and C_1-6alkyl, acyl, C_1-6alkanoyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, sulfonyl and a 5- to 14-membered non-aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F″ below:
<Substituent Group F″> represents moieties selected from the group consisting of C[0092] _1-6alkyl, oxo, cyano, acyl, carboxyl and C_1-6alkoxy).
In certain embodiments, A preferred group for (ii) above is the group consisting of cyano, oxo, C[0093] _1-6alkyl, cyano-C_1-6alkyl, C_1-6acyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl and C_1-6alkoxy.
In certain other embodiments, R[0094] ¹⁰and R¹⁴are each hydrogen, and Ar is a group represented by the formula:
[wherein R[0095] ¹¹and R¹³have the same definitions given above, R¹⁵represents (1) hydrogen or (2) a group selected from Substituent Group H above, and R¹¹and R¹⁵may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least 1 group selected from Substituent Group F above and optionally having 1 or 2 hetero atoms selected from N, S and O];
a group represented by the formula: [0096]
[wherein R[0097] ¹¹and R¹⁵have the same definitions given above, R¹⁶represents (1) hydrogen or (2) a group selected from Substituent Group H above, and R¹¹and R¹⁵or R¹⁵and R¹⁶may bond together to form a 5- to 6-membered heterocycle optionally substituted with at least one group selected from Substituent Group F above and optionally having 1 or 2 hetero atoms selected from N, S and O];
and a group represented by the formula: [0098]
[wherein R[0099] ¹¹and R¹⁵have the same definitions given above, R¹⁷and R¹⁸are the same or different and each independently represents (1) hydrogen or (2) a group selected from Substituent Group I, and R¹¹and R¹⁵R¹⁵and R¹⁷R¹⁵and R¹⁸or R¹⁷and R¹⁸may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F above and optionally having 1 or 2 hetero atoms selected from N, S and O].
The term “salt” used throughout the present specification is not particularly restrictive so long as the salt is formed with a compound of the invention and is pharmacologically acceptable. Examples include hydrogen halide acid salts (for example, hydrofluoride, hydrochloride, hydrobromide and hydroiodide), inorganic acid salts (for example, sulfate, nitrate, perchlorate, phosphate, carbonate and bicarbonate), organic carboxylate (for example, acetate, trifluoroacetate, oxalate, maleate, tartarate, fumarate and citrate), organosulfonate (for example, methanesulfonate, trifluoromethanesulfonate, ethanesulfonate, benzenesulfonate, toluenesulfonate and camphorsulfonate), amino acid salts (for example, aspartate and glutamate), quaternary amine salts, alkali metal salts (for example, sodium salts and potassium salts) or alkaline earth metal salts (for example, magnesium salts and calcium salts). In certain embodiments, salts of the invention are “pharmacologically acceptable salts” such as hydrochloride, oxalate, trifluoroacetate and the like. [0100]
Production processes for compounds of the invention and salts thereof will now be described. Various processes are possible for production of the compounds of the invention represented by the general formula (I) above and their salts, and the synthesis may be carried out by ordinary organic synthesis methods. The following representative production processes will now be presented. [0101]
[Representative Production Processes][0102]
An exemplary synthetic method for the preparation of 2-iminobenzimidazole derivatives is shown in Production Process M below. [0103]
<Production Process M>[0104]
Production Process M is an exemplary synthetic method for benzimidazole derivatives. [0105]
This scheme represents an exemplary synthetic method for a benzimidazole derivative. In the formulas, Ar has the same definition as that for the compounds represented by formula (I) in claim [0106] 1. R1 represents optionally substituted alkyl, optionally substituted alkoxy or optionally substituted amino. R2 has the same definition as R1 in the compounds represented by formula (I) in claim 1.
Step 1 represents a step of alkylation, whereby compound (M1-b) is obtained based on the method described in Antonio Da Settimo et al., J. Het. Chem., 23,1833 (1986) Yasuo Kikugawa, Synthesis, 124(1981). [0107]
Step 2 represents a step of alkylation, wherein compound (M1-c) may be obtained as a hydrobromide by dissolving a compound (M1-b) and a 2-haloethanone derivative in dimethylformamide, acetonitrile, an alcohol or the like and selecting the conditions from room temperature to reflux temperature, depending on the compound. As an alternative method, a compound (M1-b) may be reacted with sodium hydride in tetrahydrofuran or dimethylformamide and then reacted with a 2-haloethanone derivative at room temperature or while cooling on ice to yield a salt-free form of compound (M1-c), prior to treatment with an acid. Preferably, an ammonium salt may be obtained by reaction with a 5 N hydrochloric acid in an organic solvent or with 5 N hydrobromic acid in acetic acid. [0108]
This scheme is an exemplary synthetic method for a benzimidazole derivative. In the formulas, Ar has the same definition as that for the compounds represented by formula (I) in claim [0109] 1. R1 represents optionally substituted lower alkyl, lower alkoxy or lower amino. R2 has the same definition as R1 in the compounds represented by formula (I) in claim 1.
Step 1 represents a step of alkylation, wherein compound (M2-b) may be obtained by reaction with an amine in ethanol, methanol, acetonitrile or dimethylformamide at room temperature to 120° C., in the presence of sodium carbonate, potassium carbonate, cesium carbonate or potassium tert-butoxide. [0110]
Step 2 represents a step of reduction of the nitro group. Reaction is conducted in tetrahydrofuran, ethyl acetate, methanol or ethanol under a hydrogen atmosphere, in the presence of a catalytic amount of palladium-carbon. Alternatively, compound (M2-c) may be obtained by reaction with iron in hydrated methanol or hydrated ethanol at the reflux temperature of the solvent, in the presence of ammonium chloride. [0111]
Step 3 represents a step of imidazole ring formation, wherein compound (M2-d) may be obtained by reaction with cyanogen bromide in ethanol or methanol at room temperature to reflux temperature. [0112]
Step 4 represents a step of alkylation, wherein compound (M2-e) may be obtained as hydrobromide by dissolving compound (M2-d) and a 2-haloethanone derivative in dimethylformamide, acetonitrile, an alcohol or the like and selecting the conditions from room temperature to reflux temperature, depending on the compound. As an alternative method, compound (M2-d) may be reacted with sodium hydride in tetrahydrofuran or dimethylformamide and then reacted with a 2-haloethanone derivative at room temperature or while cooling on ice to yield a salt-free form of compound (M1-e), prior to treatment with an acid. Preferably, an ammonium salt may be obtained by reaction with a 5 N hydrochloric acid in an organic solvent or 5 N hydrobromic acid in acetic acid. [0113]
This scheme is an exemplary synthetic method for a benzimidazole derivative. In the formulas, Ar has the same definition as that for the compounds represented by formula (I) in claim [0114] 1. R1 represents optionally substituted lower alkyl, lower alkoxy or lower amino. R2 has the same definition as R1 in the compounds represented by formula (I) in claim 1.
Step 1 represents a step of alkylation, wherein compound (M3-b) may be obtained by reaction with an amine in ethanol, methanol, acetonitrile or dimethylformamide at room temperature to 120° C., in the presence of sodium carbonate, potassium carbonate, cesium carbonate or potassium tert-butoxide. [0115]
Step 2 represents a step of imidazole ring formation, wherein compound (M3-c) may be obtained by reaction with cyanogen bromide in ethanol or methanol at room temperature to reflux temperature. [0116]
Step 3 represents a step of alkylation, wherein compound (M3-d) may be obtained as hydrobromide by dissolving compound (M3-c) and a 2-haloethanone derivative in dimethylformamide, acetonitrile, an alcohol or the like and selecting the conditions from room temperature to reflux temperature, depending on the compound. As an alternative method, compound (M3-c) may be reacted with sodium hydride in tetrahydrofuran or dimethylformamide and then reacted with a 2-haloethanone derivative at room temperature or while cooling on ice to yield a salt-free form of compound (M3-d), prior to treatment with an acid. Preferably, an ammonium salt may be obtained by reaction with 5 N hydrochloric acid in an organic solvent or with 5 N hydrobromic acid in acetic acid. [0117]
The following are general synthesis methods for the starting materials used in the production processes described above. [0118]
<Production Process AP>[0119]
This is an exemplary process for synthesis of intermediates (AP1-c), (AP1-d), (AP1-e), (AP2-b), (AP2-c) and (AP2-d) as common starting materials for synthesis of aminophenol derivatives. [0120]
This scheme is an exemplary method for the synthesis of compound (AP1-e) from compound (AP1-a). In the formulas, R1 represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted alkoxy. R2 has the same definition as R6 and R7 in Production Process MO. [0121]
Step 1 represents a step of Friedel-Crafts acylation. Compound (AP1-b) may be obtained by reacting compound (AP1-a) with acetyl chloride in a solvent such as dichloromethane or toluene, in the presence of a Lewis acid such as aluminum chloride, zinc chloride or tin (II) chloride, at −70° C. to room temperature. [0122]
Step 2 represents a step of nitration. Compound (AP1-c) may be obtained by reaction with fuming nitric acid or concentrated nitric acid in a solvent such as toluene, hexane, ether or acetic anhydride. Alternatively, the reaction may be conducted by generating nitric acid from sodium nitrate and hydrochloric acid. [0123]
Step 3 represents a step of introducing a substituent R2 having any of various structures at the hydroxyl group of compound (AP1-c). Compound (AP1-d) may be obtained by reaction with a halide, mesylate or tosylate in a solvent such as dimethylformamide, acetonitrile, tetrahydrofuran, dichloromethane or acetone, in the presence of a base such as potassium carbonate, cesium carbonate, sodium hydrogencarbonate, trialkylamine, a pyridine derivative or sodium hydride. In the formulas, R2 has the same definition as R6 in Step 1 of Production Process MO. [0124]
Step 4 represents a step of reduction of the nitro group. Compound (AP1-e) may be obtained by reaction in a solvent such as tetrahydrofuran, ethyl acetate, methanol or ethanol under a hydrogen atmosphere, in the presence of a catalyst such as palladium-carbon. Alternatively, compound (AP1-e) may be obtained by conducting the reaction in a solvent such as hydrated methanol or hydrated ethanol in the presence of ammonium chloride, with addition of iron at the reflux temperature of the solvent. [0125]
This scheme is an exemplary method for the synthesis of (AP2-d) from (AP1-a). In the formulas, R1 represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted alkoxy. [0126]
Step 1 represents a step of bromination of the para-position relative to the phenolic hydroxyl group. Reaction with bromine is conducted in a solvent such as methanol, ethanol or chloroform. Alternatively, compound (AP2-a) may be obtained by reaction with N-bromosuccinimide in a solvent such as acetonitrile or dimethylformamide. [0127]
Step 2 represents a step of nitration. Compound (AP2-b) may be obtained by reaction with fuming nitric acid or concentrated nitric acid in a solvent such as toluene, hexane, ether or acetic anhydride. Alternatively, the reaction may be conducted by generating nitric acid from sodium nitrate and hydrochloric acid. [0128]
Step 3 represents a step of introducing a substituent R2 with any of various structures at the hydroxyl group of compound (AP2-b). Compound (AP2-c) may be obtained by reaction with a halide, mesylate or tosylate in a solvent such as dimethylformamide, acetonitrile, tetrahydrofuran, dichloromethane or acetone, in the presence of a base such as potassium carbonate, cesium carbonate, sodium hydrogencarbonate, trialkylamine, a pyridine derivative or sodium hydride. In the formulas, R2 has the same definition as R6 in Step 1 of Production Process MO. [0129]
Step 4 represents a step of reduction of the nitro group. Compound (AP2-d) may also be obtained by conducting the reaction in a solvent such as hydrated methanol or hydrated ethanol in the presence of ammonium chloride, with addition of iron at the reflux temperature of the solvent. [0130]
The following Production Processes PP to BOL are general production processes for aminophenol derivatives using compounds synthesized by Production Process AP as the starting materials. [0131]
Production Process PP is an exemplary synthetic method for a piperazine derivative. [0132]
Step 1 represents a step of treating the amino group of compound (PP-a) with bis(chloroethyl)amine hydrochloride to form a piperazine ring. Preferably, compound (PP-a) is reacted with bis(chloroethyl)amine hydrochloride in 1,2-dichlorobenzene while heating to reflux, and the reaction is conducted while removing the generated hydrogen chloride gas to yield compound (PP-b). [0133]
In the formulas, R1 represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkoxy, optionally substituted alkylamino, etc. R2 represents hydrogen, optionally substituted alkyl, etc. [0134]
The formulas in Production Process PP show only a piperazine group, but any 5- to 8-membered ring containing plural nitrogen atoms may be formed, without any restriction to piperazine. [0135]
Step 2 represents a step of introducing substituent R3 at the secondary amine position of the piperazine of compound (PP-b). Compound (PP-b) may be reacted with reagent R3-X1 (X1=halogen) in an appropriate solvent such as dichloromethane or tetrahydrofuran, in the presence of an inorganic base such as potassium carbonate or sodium hydrogencarbonate or in the presence of an organic base such as trialkylamine or a pyridine derivative to yield R3 introduced compound (PP-c). R3 of reagent R3-X1 represents optionally substituted alkyl, optionally substituted alkyl having cyano on the end or a branch, alkyl having protected or substituted carboxylic acid on the end or a branch, alkyl having protected or substituted hydroxyl on the end or a branch, alkyl having protected or substituted amino on the end or a branch, optionally substituted sulfonyl, optionally substituted acyl, or optionally substituted carbamoyl. The reagent used to introduce substituent R3 into compound (PP-b) may be, instead of R3-X1 mentioned above, di-t-butyl dicarbonate or optionally substituted isocyanate. Compound (PP-b) may be subjected to reductive amination using an optionally substituted aldehyde or ketone and sodium triacetoxyborohydride or sodium cyanoborohydride for introduction of substituent R3. [0136]
Compound (PP-c) obtained by this Production Process may be converted to the final target compound by Production Process A. [0137]
Production Process MO is an exemplary production process for a heterocyclic amino derivative. [0138]
Step 1 represents a step of treating the amino group of compound (MO-a) with a reagent represented by Z1-Y1-Y2-Y3-Z2 to form a nitrogen-containing ring. [0139]
Compound (MO-b) may be obtained by reacting compound (MO-a) with reagent Z1-Y1-Y2-Y3-Z2 in an appropriate solvent such as dimethylformamide, tetrahydrofuran or dichloromethane, in the presence of an inorganic base such as potassium carbonate, sodium hydrogencarbonate or cesium carbonate or in the presence of an organic base such as trialkylamine or a pyridine derivative. [0140]
Z1 and Z2 in the reagent Z1-Y1-Y2-Y3-Z2 represent leaving groups such as halogen or sulfonate. Y1 and Y3 represent methylene optionally substituted with alkyl, alkoxy or the like, carbonyl, carboxyl, sulfonyl or amide. Elements to form the main chain at the portion represented by —Y2-include carbon, oxygen, nitrogen and sulfur, and there are no particular restrictions on the length of the chain. Where possible, the element forming the —Y2-main chain may also have as a substituent optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkoxyalkyl, optionally substituted hydroxyalkyl, hydroxy, carbonyl, optionally protected or substituted carboxyl, optionally protected or substituted carboxyalkyl, optionally protected or substituted amine, optionally protected or substituted aminoalkyl, etc. An oxo group may also be present on the —Y2-main chain to form carbonyl, sulfonyl or sulfinyl together with carbon or sulfur on the main chain. [0141]
In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R6 represents optionally substituted alkyl, a protecting group for hydroxyl, such as methoxymethyl, tetrahydropyranyl or trialkylsilyl, or alternatively alkyl having cyano at the end or a branch, alkyl having protected or substituted carboxylic acid on the end or a branch, arylalkyl having protected or substituted carboxylic acid on the end or a branch, alkyl having protected or substituted hydroxyl on the end or a branch, arylalkyl having protected or substituted hydroxyl on the end or a branch, alkyl having protected or substituted amino on the end or a branch, arylalkyl having protected or substituted amino on the end or a branch, optionally substituted sulfonyl, optionally substituted acyl, optionally substituted carbamoyl, etc. [0142]
Step 2 represents a step of deprotection when R6 of compound (MO-b) is a protecting group for the phenolic hydroxyl group. For example, compound (MO-c) wherein R6 is methoxymethyl may be obtained by treating compound (MO-b) with an acidic mixed solvent such as 5 N hydrochloric acid/acetone or 10% aqueous perchloric acid/tetrahydrofuran. [0143]
Step 3 represents a step of introducing a new substituent R7 at the phenolic hydroxyl group of compound (MO-c). [0144]
R7 has the same definition as R6 in Step 1 of Production Process MO. [0145]
Compound (MO-d) wherein X2 of reagent R7-X2 described below is a leaving group such as halogen or sulfonate may be synthesized in the following manner. Compound (MO-d) may be obtained by reacting compound (MO-c) with reagent R7-X2 in an appropriate solvent such as dimethylformamide, acetonitrile, diethyl ether, tetrahydrofuran or dichloromethane, in the presence of an inorganic base such as potassium carbonate, sodium hydrogencarbonate or cesium carbonate or in the presence of an organic base such as trialkylamine or a pyridine derivative, or in the presence of sodium hydride. [0146]
Compound (MO-d) wherein R7 is methyl may be obtained at a high yield by reacting compound (MO-c) with diazomethane in diethyl ether or with trimethylsilyldiazomethane in acetonitrile-diisopropylethylamine-methanol. [0147]
Compound (MO-d) wherein X2 in reagent R7-X2 is hydroxyl may be obtained by reacting compound (MO-c) with reagent R7-X2 by the publicly known Mitsunobu reaction in an appropriate solvent such as tetrahydrofuran or toluene. [0148]
In Production Process MO, R6 and R7 may sometimes undergo conversion to a structure which is not defined herein by a method easily predictable by a person skilled in the art at an appropriate stage after introduction. Likewise, the —N—Y1-Y2-Y3(—N) portion obtained by cyclization in Step 1 may sometimes also undergo conversion to a structure which is not defined herein. (Conversion of the —N—Y1-Y2-Y3(—N) portion is described in some of the following Production Process examples). [0149]
Compounds (MO-b), (MO-c) and (MO-d) obtained in this Production Process may be converted to the final target compounds by Production Process A. [0150]
<Production Process PR>[0151]
Production Process PR is an exemplary synthetic method for pyrrolidine derivatives. [0152]
Scheme PR-1 is an exemplary production scheme whereby the —N—Y1-Y2-Y3(—N) portion obtained by cyclization in Step 1 of Production Process MO may undergo additional structural conversion. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R10 and R11 have the same definitions as R6 and R7 in Production Process MO. Although only methoxymethyl is mentioned as a protecting group for the phenolic hydroxyl group of compounds (PR1-a) and (PR1-b), there is no limitation to methoxymethyl. [0153]
Step 1 represents a step of introducing a substituent R10 at the hydroxyl group of compound (PR1-a). The reaction is conducted using reagent R10-X3 in an appropriate alkaline hydrated organic solvent, in the presence of a phase transfer catalyst. Preferably, compound (PR1-b) is obtained by reaction of reagent R10-X3 with compound (PR1-a) in a mixture of 50% aqueous sodium hydroxide and toluene in the presence of tetrabutylammonium bromide. Here, X3 is a leaving group such as halogen or sulfonate. [0154]
Step 2 represents a step of treating compound (PR1-b) in the same manner as Step 2 of Production Process MO to yield compound (PR1-c). [0155]
Step 3 represents a step of introducing a new substituent R11 at the phenolic hydroxyl group of compound (PR1-c). Compound (PR1-c) may be treated in the same manner as for introduction of R7 in Step 3 of Production Process MO to yield R11 introduced compound (PR1-d). [0156]
Step 4 represents a step of treating compound (PR1-a) in the same manner as Step 2 of Production Process MO to yield compound (PR1-e). [0157]
Step 5 represents a step of selectively introducing substituent R11 only at the phenolic hydroxyl group of compound (PR1-e). Utilizing the difference in reactivity between the two hydroxyl groups of compound (PR1-e), treatment may be carried out in the same manner as for introduction of R7 in Step 3 of Production Process MO to yield R11 introduced compound (PR1-f). [0158]
Step 6 represents a step of treating compound (PR1-f) in the same manner as Step 1 of this Scheme PR-1 to yield compound (PR1-d). [0159]
Compounds (PR1-b) and (PR1-d) obtained in this Scheme PR-1 may be converted to the final target compounds by Production Process A. [0160]
Scheme PR-2 is another exemplary production scheme whereby the —N—Y1-Y2-Y3(—N) portion obtained by cyclization in Step 1 of Production Process MO may undergo additional structural conversion. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R15 and R20 have the same definitions as R6 and R7 in Production Process MO. [0161]
Step 1 represents a step of replacing the hydroxyl group of compound (PR1-a) with a substituent R14 (F or CN). When R14 is fluoro, compound (PR1-a) may be treated with diethylaminosulfur trifluoride (DAST) in dichloromethane to yield compound (PR2-a: R14=F). When R14 is cyano, the hydroxyl group of compound (PR1-a) may first be converted to a leaving group with an acyl chloride reagent such as methanesulfonyl chloride in an appropriate solvent such as dichloromethane, in the presence of a base such as triethylamine. A hydrogen cyanide salt may then be reacted with this intermediate to introduce a cyano group. Preferably, the intermediate is added to dimethylformamide and reacted with sodium cyanide in the presence of tetrabutylammonium iodide to yield compound (PR2-a: R14=CN). [0162]
Step 2 represents a step of treating compound (PR2-a)(R14=F or CN) in the same manner as Step 2 of Production Process MO to yield compound (PR2-b)(R14=F or CN). [0163]
Step 3 represents a step of introducing substituent R15 at the phenolic hydroxyl group of compound (PR2-b)(R14=F or CN). Compound (PR2-b) may be treated in the same manner as for introduction of R7 in Step 3 of Production Process MO to yield R15 introduced compound (PR2-c)(R14=F or CN). [0164]
Step 4 represents a step of converting compound (PR2-c) wherein R14=CN to compound (PR2-d) wherein cyano may be converted to carboxyl by alkali hydrolysis. Preferably, compound (PR2-c) wherein R14=CN may be reacted by heating to reflux in a mixed solvent of aqueous sodium hydroxide and ethanol to yield compound (PR2-d). [0165]
Step 5 represents a step of esterifying or amidating the carboxylic acid group of compound (PR2-d) for introduction of a substituent R18 by common methods. The carboxylic acid group of compound (PR2-d) may be converted to an active species by a common method such as an acid mixing method using a chloroformic acid ester or an acid chloride method using oxalyl chloride, and then reacted with an alcohol or amine for conversion to (PR2-e). Alternatively, (PR2-d) may be esterified by reaction with the corresponding alkyl halide reagent in the presence of an appropriate base or by reaction with di-tert-butyl dicarbonate in tert-butyl alcohol in the presence of dimethylaminopyridine. Compound (PR2-d) may also be subjected to dehydration reaction using an alcohol or amine and a peptide-forming condensing agent, for conversion to compound (PR2-e). The synthesis may also be carried out by other suitable known reactions. R18 represents amino or alkoxy. [0166]
Step 6 represents a step of subjecting compound (PR2-a: R14=CN) to alkali hydrolysis in the same manner as Step 4 followed by treatment in the same manner as the esterification in Step 5, and then ketal protection of the carbonyl group of the acetophenone. After converting compound (PR2-a: R14=CN) to a carboxylic acid ester, it may be reacted with a ketalizing reagent such as methyl orthoformate under acidic conditions to yield compound (PR2-f). Preferably, the methyl orthoformate is reacted with the carbonyl group in methanol in the presence of an acid catalyst such as camphorsulfonic acid or p-toluenesulfonic acid and Molecular Sieve 3A, to yield compound (PR2-f). [0167]
Step 7 represents a step of reducing the ester group of compound (PR2-f) for conversion to a hydroxymethyl group, and then selectively deprotecting only the ketal protection of the carbonyl group of the acetophenone. First, compound (PR2-f) is reacted with an ester-reducing reagent such as lithium aluminum hydride in an appropriate solvent such as tetrahydrofuran or diethyl ether, for conversion to a hydroxymethyl group. Next, under mildly acidic conditions, and preferably under conditions with an acetic acid-tetrahydrofuran-water (4:1:1) mixed acid solvent, the ketal protecting group for the carbonyl group is selectively deprotected while leaving the methoxymethyl group for the phenolic hydroxyl, to yield compound (PR2-g). [0168]
Step 8 represents a step of converting the hydroxyl group of compound (PR2-g) to substituent R19 (cyano or various alkoxy). [0169]
When R19 is cyano, treatment is carried out in the same manner as for conversion in Step 1 when R14 is cyano, to yield compound (PR2-h) wherein hydroxymethyl of compound (PR2-g) may be converted to cyanomethyl, in which case R19 represents cyano. When R19 is alkoxy, compound (PR2-g) is treated in the same manner as Step 1 of Scheme PR-1 to yield compound (PR2-h) for conversion to alkoxy, in which case R19 has the same definition as OR10 in Scheme PR-1. [0170]
Step 9 represents a step of deprotecting the methoxymethyl group serving as the protecting group for the phenolic hydroxyl group of compound (PR2-h), and then introducing a substituent R20. First, compound (PR2-h) is treated in the same manner as Step 2 of Production Process MO to remove the methoxymethyl group. It is then treated in the same manner as for introduction of R7 in Step 3 of Production Process MO to yield compound R20 introduced (PR2-i). [0171]
Compounds (PR2-c), (PR2-e) and (PR2-i) obtained in this Scheme PR-2 may be converted to the final target compounds by Production Process A. [0172]
Scheme PR-3 is an exemplary production scheme whereby the —N—Y1-Y2-Y3(—N) portion obtained by cyclization in Step 1 of Production Process MO may undergo additional structural conversion. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R23, R24 and R25 have the same definitions as R6 and R7 in Production Process MO. [0173]
Step 1 represents a step of treating compound (PR3-a) in the same manner as Step 1 of Scheme PR-1 to yield compound (PR3-b) having one substituent R24 introduced therein and compound (PR3-c) having two substituents R24 introduced therein. Alternatively, when R24 is methoxymethyl or the like, an excess of methoxymethyl chloride may be reacted with compound (PR3-a) in the presence of diisopropylethylamine to yield compounds (PR3-b) and (PR3-c). Compounds (PR3-b) and (PR3-c) may be separated by silica gel column chromatography. [0174]
Step 2 represents a step of treating compound (PR3-b) in the same manner as Step 1 to yield compound (PR3-d) having a newly introduced substituent R25. [0175]
Step 3 represents a step of stereoinversion of the hydroxyl group of compound (PR3-b) to yield compound (PR3-e). Compound (PR3-b) is reacted with m-nitrobenzenesulfonyl chloride in dichloromethane in the presence of triethylamine and dimethylaminopyridine. It is then treated with cesium acetate while heating in dimethylsulfoxide to yield a hydroxyl-inverted acetate. This is treated with potassium carbonate in methanol to yield hydroxyl-inverted compound (PR3-e). [0176]
Compounds (PR3-b), (PR3-c) and (PR3-d) obtained in Scheme PR-3 may be converted to the final target compounds by Production Process A. Compound (PR3-e) may also be treated in the same manner as Step 2 of this scheme and then converted to the final target compound by Production Process A. [0177]
Scheme PR-4 is an exemplary production scheme whereby the —N—Y1-Y2-Y3(—N) portion obtained by cyclization in Step 1 of Production Process MO may undergo additional structural conversion. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R26 has the same definition as R6 and R7 in Production Process MO. [0178]
Step 1 represents a step of treating compound (PR4-a) with Lawesson's reagent while heating in 1,4-dioxane to yield a thioamide (PR4-b). [0179]
Step 2 represents a step of treating compound (PR4-b) with ethyl O-trifluoromethanesulfonylhydroxyacetate, triphenylphosphine and triethylamine to yield compound (PR4-c). [0180]
Step 3 represents a step of reacting compound (PR4-c) with sodium triacetoxyborohydride in 1,2-dichloroethane in the presence of acetic acid for reduction of the enamine to yield compound (PR4-d). [0181]
Step 4 represents a step of converting compound (PR4-d) to a carboxylic acid derivative (PR4-e) under appropriate conditions such that substituent R26 is not affected. Generally, it is treated with aqueous sodium hydroxide or aqueous lithium hydroxide in an alcohol or an alcohol-tetrahydrofuran mixed solvent for alkali hydrolysis to yield compound (PR4-e). [0182]
Step 5 represents a step of treating compound (PR4-e) with di-tert-butyl dicarbonate in tert-butanol in the presence of dimethylaminopyridine to yield the tert-butylesterified compound (PR4-f). [0183]
Compounds (PR4-c), (PR4-d) and (PR4-f) obtained in this Scheme (PR-4) may be converted to the final target compounds by Production Process A. [0184]
Scheme PR-5 is an exemplary production scheme whereby the —N—Y1-Y2-Y3 (—N) portion obtained by cyclization in Step 1 of Production Process MO may undergo additional structural conversion. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R27 has the same definition as R6 and R7 in Production Process MO. [0185]
Step 1 represents a step of treating compound (PR5-a) with a catalytic amount of rhodium (II) acetate dimer and the known reagent diethyl diazomalonate while heating in toluene, to yield compound (PR5-b). [0186]
Step 2 represents a step of treating compound (PR5-b) with equivalents of sodium ethoxide and ethyl acrylate while heating in ethanol to yield the cyclized compound (PR5-c). [0187]
Step 3 represents a step of treating compound (PR5-c) with 5 N hydrochloric acid while heating in ethanol to yield compound (PR5-d) having the methoxymethyl protecting group removed. [0188]
Step 4 represents a step of converting compound (PR5-d) to compound (PR5-e) having a newly introduced substituent R27. Compound (PR5-e) may be obtained by treatment in the same manner as for introduction of R7 in Step 3 of Production Process MO. [0189]
Step 5 represents a step of treating compound (PR5-e) with 1,2-bis(trimethylsiloxy)ethane and triethylsilyltriflate in dichloromethane to yield compound (PR5-f), wherein the acetyl carbonyl of compound (PR5-e) is ketal-protected. [0190]
Step 6 represents a step of reducing the lactam carbonyl of compound (PR5-f) for conversion to methylene. Compound (PR5-f) may be reacted with carbonylhydridotris(triphenylphosphine)rhodium(I) and diphenylsilane in an appropriate solvent such as tetrahydrofuran to yield compound (PR5-g). [0191]
Step 7 represents a step of reacting compound (PR5-g) in 5% hydrochloric acid-tetrahydrofuran to yield the ketal-deprotected compound (PR5-h). [0192]
Compounds (PR5-d), (PR5-e) and (PR5-h) obtained in this Scheme PR-5 may be converted to the final target compounds by Production Process A. [0193]
This Production Process PS is an exemplary synthetic method for a piperidine derivative. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R28 and R30 have the same definitions as R6 and R7 in Production Process MO. [0194]
Step 1 represents a step of reacting compound (PS-a) with formaldehyde to produce an imine, and then subjecting it to hetero Diels-Alder reaction with a diene having an enol ether structure to form an oxopiperidine ring. Preferably, Compound (PS-a) is reacted with 37% formalin in dichloromethane in the presence of magnesium sulfate to produce an imine, and the reaction mixture is filtered with celite. After adding 2-trimethylsilyloxy-1,3-butadiene and toluene to the filtrate and cooling to −70° C., a 1 M hexane solution of diethylaluminum chloride is added dropwise and the temperature is raised. After completion of the reaction, the mixture is replaced with a tetrahydrofuran solution and is treated with 1 N hydrochloric acid to yield compound (PS-b) having the silylenol ether converted to a ketone. [0195]
Step 2 represents a step of treating compound (PS-b) with p-toluenesulfonylmethyl isocyanide (TosMIC) in dimethoxyethane-tert-butanol in the presence of potassium tert-butoxide, to yield compound (PS-c) having oxo converted to cyano. [0196]
Step 3 represents a step of reacting the carbonyl group of compound (PS-b) with any of various organometallic reagents to yield a tert-alcohol (PS-d) having an added substituent R29. For example, compound (PS-b) may be reacted with methylmagnesium bromide in diethyl ether to yield compound (PS-d) having an added methyl group. R29 represents alkyl, alkenyl or alkynyl. [0197]
Step 4 represents a step of treating compound (PS-b) with a reducing agent for conversion to an alcohol compound (PS-e). Various reducing agents may be used, and treatment with sodium borohydride in a methanol-dichloromethane mixed solvent is preferred to yield compound (PS-e). [0198]
Step 5 represents a step of treating compound (PS-e) in the same manner as Step 1 of Scheme PR-1 of Production Process PR to yield compound (PS-f) having a newly introduced substituent R30 at the hydroxyl group. Substituent R30 has the same definition as R6 and R7 in Production Process MO. [0199]
Step 6 represents a step of Horner-Emmons reaction at the carbonyl group of compound (PS-b) to yield the carbon-carbon bond formed unsaturated ester (PS-g). After treating a tert-butyl diethylphosphonoacetate with sodium hydride in 1,2-dimethoxyethane, compound (PS-b) dissolved in 1,2-dimethoxyethane is added to yield Compound (PS-g). [0200]
Step 7 represents a step of 1,4-reduction of the unsaturated ester. Compound (PS-g) may be treated with sodium borohydride in a dichloromethane-methanol mixed solvent in the presence of a catalytic amount of nickel (II) chloride-6 hydrate, or reacted with magnesium in methanol for selective 1,4-reduction of the unsaturated ester to yield compound (PS-h). [0201]
A piperidine derivative may also be synthesized by the following Steps 8 to 10. [0202]
Step 8 represents a step of treating compound (PS-i) in the same manner as Step 1 to yield compound (PS-j), with simultaneous formation of an oxopiperidine ring and deprotection of the methoxymethyl group serving as the phenolic hydroxyl group-protecting group. [0203]
Step 9 represents a step of treating compound (PS-j) in the same manner as for introduction of R7 in Step 3 of Production Process MO, to yield compound (PS-k) substituted with substituent R28. [0204]
Step 10 represents a step of selectively protecting the carbonyl group of the acetophenone of compound (PS-k). After adding compound (PS-k) to tetrahydrofuran, adding triethylamine and cooling to −70° C., the mixture is treated with tert-butyldimethylsilyl trifluoromethanesulfonate. The state of the reaction is periodically examined by thin-layer column chromatography, and the temperature is gradually raised if necessary. Water may be added at low temperature to stop the reaction to yield compound (PS-m). [0205]
Finally, compound (PS-m) may be treated in the same manner as in Steps 2, 3 and 0.4. Alternatively, it may be converted directly to an acyl bromide according to Production Process A for conversion to the final target compound. [0206]
Compounds (PS-b), (PS-c), (PS-d), (PS-e), (PS-f), (PS-g), (PS-h), (PS-j) and (PS-k) obtained in this Production Process may be converted to the final target compounds by Production Process A. [0207]
This scheme is an exemplary synthesis for an aniline derivative. In the formulas, R1 has the same definition as in Step 1 of Production Process PP. R31, R32 and R33 have the same definitions as R6 and R7 in Production Process MO. [0208]
Step 1 represents a step of introducing one or two substituents R31 at the amino group of compound (AN1-a). Compound (AN1-a) may be treated in approximately the same manner as for introduction of R7 at the hydroxyl group in Step 3 of Production Process MO to yield compounds (AN1-b) and (AN1-c). When R31 is bonded to the aniline amino group as simple alkyl and not via acyl or sulfonyl (when R31-I or R31-Br is used as the reagent, etc.), a prolonged reaction with heating may be necessary to introduce the substituent R31. Incidentally, compounds (AN1-b) and (AN1-c) may be easily separated and purified by silica gel column chromatography. [0209]
Step 2 represents a step of treating compound (AN1-b) in the same manner as Step 1 to yield compound (AN1-d) having a newly introduced substituent R32. [0210]
Step 3 represents a step of treating compounds (AN1-c) and (AN1-d) in the same manner as Step 2 of Production Process MO to yield the respective compounds (AN1-e) and (AN1-f). [0211]
Step 4 represents a step of treating compounds (AN1-e) and (AN1-f) in the same manner as for introduction of R7 in Step 3 of Production Process MO to yield the respective compounds (AN1-g) and (AN1-h). [0212]
Step 5 represents a step of using compound (AN1-i) as the starting material for treatment in the same manner as Step 1 to yield compound (AN1-j) having substituents R31 and R33. Compound (AN1-g) can also be obtained by this method. [0213]
Step 6 represents a step of treating compound (AN1-j) in the same manner as Step 2 to yield compound (AN1-h). [0214]
Step 7 represents a step of treating compound (AN1-i) in the same manner as the ketalizing reaction of Step 6 in Scheme PR-2, to yield compound (AN1-k). [0215]
Step 8 represents a step of reductive amination of compound (AN1-k) using an aldehyde or ketone (represented by R34—(C═O)—R35) and a reducing agent to obtain compound (AN1-m). [0216]
Compound (AN1-k) may be reacted with sodium cyanoborohydride in a methanol-acetic acid mixed solvent or reacted with sodium triacetoxyborohydride in a 1,2-dichloroethane-acetic acid mixed solvent, to directly yield compound (AN1-m) having the ketal protecting group also deprotected. Either R34 and R35 may be hydrogen, or R34 and R35 may together form a ring. [0217]
Step 9 represents a step of reductive amination of compound (AN1-i) without ketal protection, using an aldehyde or ketone (represented by R34—(C═O)—R35) and a reducing agent to yield compound (AN1-m). Reaction will usually be conducted with sodium triacetoxyborohydride in a 1,2-dichloroethane-acetic acid mixed solvent. [0218]
Compounds (AN1-b), (AN1-c), (AN1-d), (AN1-e), (AN1-f), (AN1-g), (AN1-h), (AN1-j) and (AN1-m) obtained in this Scheme AN-1 may be converted to the final target compounds by Production Process A. [0219]
Scheme AN-2 is an exemplary synthetic method for further structural conversion of the substituents on the aniline nitrogen of the intermediate synthesized in Scheme AN-1. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R36 has the same definition as R6 and R7 in Production Process MO. Either or both R37 and R38 may form an amide bond with the aniline nitrogen, or the substituents may have ester structures. One of the substituents on the aniline nitrogen of the starting material (AN2-a) may be hydrogen. [0220]
Step 1 represents a step of treating compound (AN2-a) in the same manner as the ketalizing reaction of Step 6 in Scheme PR-2 of Production Process PR, to yield compound (AN2-b) having the carbonyl group protected. [0221]
Step 2 represents a step of treating compound (AN2-b) with a reducing agent for conversion of amide to methyleneamino (from —N—CO— to —N—CH2-), or of an ester to an alcohol (from —CO—O— to —CH2-OH, from —O—CO— to —OH). Preferably, compound (AN2-b) is treated with lithium aluminum hydride in diethyl ether to yield compound (AN2-c). Substituents R39 and R40 are defined as the structures resulting after this conversion of R37 and R38. [0222]
Step 3 represents a step of treating compound (AN2-c) in the same manner as the ketal deprotection reaction of Step 7 in Scheme PR-2, to yield compound (AN2-d). [0223]
Step 4 represents a step carried out only when compound (AN2-d) has a hydroxyl group on substituent R39 or R40, and here a new substituent is introduced at the hydroxyl group to yield compound (AN2-e) by conversion to substituents R41 and R42. [0224]
The reaction of this step is conducted in the same manner as Step 1 in Scheme PR-1 of Production Process PR. Compounds (AN2-d) and (AN2-e) obtained in this Scheme (AN-2) may be converted to the final target compounds by Production Process A. [0225]
<Production Process BO>[0226]
The following Schemes BO-1, 2, 3 and 4 of Production Process BO are general synthesis methods for benzoxazine derivatives. [0227]
In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 represents hydrogen, optionally substituted alkyl or the like. R3 represents hydrogen, halogeno, oxo, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted carboxyl or optionally substituted carbamoyl. [0228]
Step 1 represents a step of acylation of the amino group. Compound (BO1-b) may be obtained either by reaction with an acyl chloride at room temperature in a solvent such as tetrahydrofuran, methylene chloride or acetonitrile in the presence of a base such as pyridine or triethylamine, or by reaction with an acid anhydride in a pyridine solution. [0229]
Step 2 represents a step of deprotection of the methoxymethyl group protecting the alcohol. Compound (BO1-c) may be obtained by reaction with dilute aqueous hydrochloric acid and 10% aqueous perchloric acid in a solvent such as tetrahydrofuran or acetone at room temperature. [0230]
Step 3 represents a step of alkylation of the hydroxyl group and the amino group. Compound (BO1-d) may be obtained by reaction with a dihalide, dimesylate or ditosylate in a dimethylformamide solution in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydride, while heating from room temperature to 150° C. [0231]
Step 4 represents a step of deacylation. Compound (BO1-e) may be obtained either by reaction with an aqueous sodium hydroxide solution in a solvent such as methanol, ethanol or tetrahydrofuran, at room temperature to the reflux temperature of the solvent, or by reaction in an aqueous hydrochloric acid solution at room temperature to the reflux temperature of the solvent. [0232]
Compounds (BO1-d) and (BO1-e) obtained in this Scheme BO-1 may be converted to the final target compounds by Production Process A. [0233]
In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 has the same definition as R3 in Scheme BO-1. [0234]
Step 1 represents a step of alkylation of the hydroxyl group. Compound (BO2-b) may be obtained by reaction with a dihalide, dimesylate or ditosylate in a dimethylformamide solution while heating from room temperature to 150° C. [0235]
Step 2 represents a step of forming an oxazine ring. Reaction is conducted with a dihalide, dimesylate or ditosylate in a dimethylformamide solution in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydride, while heating from room temperature to 150° C. Reaction is then conducted at room temperature in an ethanol or methanol solution in the presence of a catalytic amount of palladium-carbon in a hydrogen atmosphere to yield compound (BO2-c). [0236]
Compound (BO2-c) obtained in this Scheme BO-2 may be converted to the final target compound by Production Process A. [0237]
In the formulas, R1 represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted alkoxy. R2 represents hydrogen, optionally substituted alkyl, alkyl having cyano at the end or a branch, optionally substituted alkoxy, optionally substituted arylalkyl, optionally substituted acyl, optionally substituted sulfonyl, optionally substituted carbamoyl or optionally substituted carboxyl. [0238]
Step 1 represents a step of alkylating, acylating, substituted carbamoylating or urethanating the amino group, by any of the following methods 1 to 4. [0239]
1. Compound (BO3-b) may be obtained by reaction with a halide, mesylate or tosylate in a dimethylformamide solution in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydride, while heating from room temperature to 150° C. [0240]
2. Compound (BO3-b) may be obtained either by reaction with an acyl chloride, sulfonyl chloride or isocyanate at room temperature in a solvent such as tetrahydrofuran, methylene chloride or acetonitrile, in the presence of a base such as pyridine or triethylamine, or by reaction with an acid anhydride in a pyridine solution. [0241]
3. Compound (BO3-b) may be obtained by reaction with ethyl N-(1-cyano)iminoformate in methanol or ethanol in the presence of a catalytic amount of 4-dimethylaminopyridine, at room temperature to the reflux temperature of the solvent. [0242]
4. Compound (BO3-b) may be obtained by reaction with trimethyl orthoformate or triethyl orthoformate in methanol or ethanol in the presence of a catalytic amount of p-toluenesulfonic acid or camphorsulfonic acid, ketal protection of the acetyl group and introduction of different substituents by methods 1 to 3 above, followed by deprotection under acidic conditions. [0243]
Compound (BO3-b) obtained in this Scheme BO-3 may be converted to the final target compound by Production Process A. [0244]
In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 has the same definition as R3 in Scheme BO-1. R3 has the same definition as R2 in Scheme BO-3. [0245]
Step 1 represents a step of alkylation. Compound (B04-b) may be obtained by the method described in Tawada, H., Sugiyama, Y., Ikeda, H., Yamamoto, Y., Meguro, K; Chem. Pharm. Bull., 38(5), 1238-1245(1990), or by reaction with allyl bromide, maleic anhydride or the like in a solvent such as methanol, ethanol or toluene in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydrogencarbonate at room temperature to the reflux temperature of the solvent, followed by reaction in methanol or ethanol in the presence of a base such as potassium carbonate or triethylamine, at room temperature to the reflux temperature of the solvent. [0246]
Step 2 represents a step of alkylating, acylating, substituted carbamoylating or urethanating the amino group. Compound (BO4-c) may be obtained by treatment in the same manner as Step 1 of Scheme BO-3. Compounds (BO4-b) and (BO4-c) obtained in Scheme BO-4 may be converted to the final target compound by Production Process A. [0247]
Production Process BOL is an exemplary synthetic method for a benzoxazole derivative. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 represents hydrogen, optionally substituted alkyl or optionally substituted alkoxy. [0248]
Step 1 represents a step of forming an oxazole ring. Compound (BOL-b) may be obtained by reaction with an acid chloride in a solvent such as tetrahydrofuran, methylene chloride or acetonitrile in the presence of a base such as triethylamine, followed by reaction with dilute aqueous hydrochloric acid or p-toluenesulfonic acid in a solvent such as ethanol, methanol, tetrahydrofuran or methyl ethyl ketone. [0249]
The benzoxazoleethanone derivative (BOL-b) obtained in Production Process BOL may be converted to the final compound by Production Process A. [0250]
<Production Process CA>[0251]
Schemes CA-1, 2 and 3 below in Production Process CA are general synthesis methods for catechol derivatives. [0252]
In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2, R3 and R4 have the same definitions as R6 and R7 in Production Process MO. [0253]
Step 1 represents a step of methoxymethylating the hydroxyl group of compound (CA1-a). Compound (CA1-b) is obtained by reaction of compound (CA1-a) and sodium hydride in dimethylformamide at room temperature, followed by reaction with methoxymethyl chloride (MOM-Cl). [0254]
Step 2 represents a step of introducing a formyl group by ortholithiation utilizing the substituent effect of the methoxymethyl group of compound (CA1-b). The orthoformylated compound (CA1-c) is obtained by treatment of compound (CA1-b) with n-butyllithium in diethyl ether while cooling on ice in the presence of tetramethylethylenediamine, followed by treatment with a formylating agent such as dimethylformamide or N-formylmorpholine. [0255]
Step 3 represents a step of brominating the para-position relative to the methoxymethyl group of compound (CA1-c). Compound (CA1-d) is obtained by reaction of compound (CA1-c) with bromine in methanol at room temperature, and removal of the methoxymethyl group by the hydrogen bromide generated in the system. [0256]
Step 4 represents a step of introducing any of various substituents at the hydroxyl group of compound (CA1-d). Compound (CA1-e) is obtained by the same method as for introduction of R7 in Step 3 of Production Process MO. [0257]
Step 5 represents a step of oxidative conversion of the formyl group to a hydroxyl group. Compound (CA1-f) is obtained by reacting compound (CA1-e) with m-chloroperbenzoic acid in dichloromethane at room temperature or with heating, and then hydrolyzing the purified ester using potassium carbonate in methanol. [0258]
Step 6 represents a step of obtaining R3 introduced compound (CA1-g) by the same method as in Step 4 of Scheme CA-1. [0259]
Step 7 represents a step of conversion to substituent R4 when R2 is a hydroxyl-protecting group. Compound (CA1-h) is obtained in the same manner as the continuous treatment in Steps 2 and 3 of Production Process MO. [0260]
Compounds (CA1-g) and (CA1-h) obtained in this Scheme CA-1 may be converted to the final target compound by Production Process A. [0261]
Scheme CA-2 is an exemplary synthetic method for a cyclic catechol derivative. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 and R4 have the same definitions as R6 and R7 in Production Process MO. [0262]
Step 8 represents a step of conversion to a catechol when R2 is an eliminable hydroxyl-protecting group. When R2 is methoxymethyl, a diol (catechol) (CA2-a) is obtained by treating compound (CA1-f) with 6 N hydrochloric acid. [0263]
Step 9 represents a step of cyclizing the catechol by alkylation. Compound (CA2-a) is reacted with a 1,2-dibromoethyl derivative in a solvent such as dimethylformamide, acetonitrile or acetone in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydride, to yield a fused dioxane ring (CA2-b). Compound (CA2-a) may also be treated with acetone in the presence of phosphorus pentaoxide to yield a 5-membered cyclic product (CA2-b) as an acetonide. [0264]
Compound (CA2-b) obtained in this Scheme CA-2 may be converted to the final target compound by Production Process A. [0265]
Scheme CA-3 is an exemplary synthetic method for a disubstituted catechol derivative. In the formulas, R5 and R6 have the same definitions as R6 and R7 in Production Process MO. [0266]
Step 10 represents a step of obtaining compound (CA3-b) by the same method as in Step 4 of Scheme CA-1 using the catechol (CA3-a) as the starting material. [0267]
Step 11 represents a step of treating compound (CA3-b) by the same method as in Step 3 of Scheme CA-1 to yield compound (CA3-c) which is selectively brominated at the para-position relative to the non-substituted hydroxyl group. [0268]
Step 12 represents a step of obtaining R6 introduced compound (CA3-d) by the same method as in Step 4 of Scheme CA-1. [0269]
Compound (CA3-d) obtained by Scheme CA-3 may be converted to the final target compound by Production Process A. [0270]
<Production Process CO>[0271]
Schemes CO-1, CO-2, CO-3, CO-4, CO-5, CO-6, CO-7, CO-8 and CO-9 in Production Process CO are general synthesis methods for phenol and phenoxy derivatives. [0272]
In the formulas of Scheme CO-1, R1 and R2 have the same definition as R1 in Step 1 of Production Process PP. R3 has the same definition as R6 and R7 in Production Process MO. [0273]
Step 1 represents a step of Friedel-Crafts acylation. Compound (CO1-b) is obtained by reaction with acetyl chloride in methylene chloride or toluene in the presence of a Lewis acid such as aluminum chloride, zinc chloride or tin (II) chloride, at −70° C. to room temperature. [0274]
Step 2 represents a step of alkylation, carbonation, sulfonation or the like. [0275]
1. Compound (CO1-c) may be obtained by reaction with a halide, mesylate or tosylate in a dimethylformamide solution in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydride, while heating from room temperature to 150° C. [0276]
2. Compound (CO1-c) may be obtained either by reaction with an acyl chloride, sulfonyl chloride or isocyanate in a solvent such as tetrahydrofuran, methylene chloride or acetonitrile in the presence of a base such as pyridine or triethylamine, at −15° C. to room temperature, or by reaction with an acid anhydride in a pyridine solution. [0277]
3. Compound (CO1-c) may also be obtained by reaction with phenyl chloroformate in a solvent such as tetrahydrofuran, methylene chloride or acetonitrile in the presence of a base such as pyridine or triethylamine, followed by reaction with an amine. [0278]
Compounds (CO1-b) and (CO1-c) obtained in this Scheme CO-1 may be converted to the final target compounds by Production Process A. Compound (CO1-a) may also be used in the conversion of compound (A4-c) in Scheme A-4 of Production Process A. [0279]
Scheme CO-2 is an exemplary synthetic method for an aromatic-substituted benzene derivative. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 has the same definition as R6 and R7 in Production Process MO. R3 represents an aromatic ring. [0280]
Step 1 represents a step of introducing an aromatic substituent using the Stille coupling method. Compound (CO2-b) is obtained by reaction with aromatic-substituted tributyltin in a solvent such as toluene or xylene under a nitrogen atmosphere in the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium, at the reflux temperature of the solvent. [0281]
Compound (CO2-b) obtained in this Scheme CO-2 may be converted to the final target compound by Production Process A. [0282]
Scheme CO-3 is an exemplary synthetic method for a benzylamine derivative. In the formulas, R1 and R3 have the same definition as R1 in Step 1 of Production Process PP. R2 and R2′ have the same definitions as R6 and R7 in Production Process MO. R4 and R5 have the same definition as R2 in Scheme BO-3. R4 and R5 may also form a ring together. X represents hydroxyl or sulfonate. [0283]
Step 1 represents a step of introducing an alkyl halide. Compound (CO3-b) is obtained by reaction with sodium borohydride in methanol or ethanol, followed by reaction with methanesulfonyl chloride or the like in dimethylformamide, in the presence of a base such as pyridine or triethylamine. [0284]
Step 2 represents a step of amination. [0285]
1. Compound (CO3-c) may be obtained by reaction with an amine in methanol, ethanol, acetonitrile or tetrahydrofuran. [0286]
2. Compound (CO3-c) may be obtained by reaction with an amine in dimethylformamide in the presence of a base such as potassium carbonate or sodium hydride. [0287]
3. When X is hydroxyl, compound (CO3-c) may be obtained by reaction with diphenylphosphoryl azide in toluene in the presence of a base such as 1,8-diazabicyclo [5.4.0] undec-7-ene to yield an azide, followed by reaction with a trialkylphosphine or triphenylphosphine in tetrahydrofuran-water. [0288]
Step 3 represents a step of converting R2 to substituent R2′ when R2 is a hydroxyl-protecting group. Compound (CO3-d) is obtained in the same manner as the continuous treatment in Steps 2 and 3 of Production Process MO. [0289]
Compounds (CO3-c) and (CO3-d) obtained in this Scheme CO-3 may be converted to the final target compounds by Production Process A. [0290]
Scheme CO-4 is an exemplary synthetic method for phenol and phenoxy derivatives by Wittig reaction. In the formulas, R1 has the same definition as R1 in Production Process PP. R2 and R2′ have the same definitions as R6 and R7 in Production Process Mo. R3 represents hydrogen or lower alkyl. R4 represents optionally substituted alkyl, optionally substituted carboxyl, cyano or the like. [0291]
Step 1 represents a step of alkylation utilizing Wittig reaction. Reaction is conducted with a phosphorane derivative in methylene chloride or tetrahydrofuran. Alternatively, compound (CO4-b) may be obtained by reaction with a phosphonium salt or phosphonate in tetrahydrofuran or dimethylformamide in the presence of a base such as potassium tert-butoxide or sodium hydride. [0292]
Step 2 represents a step of reducing the olefin. Compound (CO4-c) may be obtained by accomplishing reduction by reaction in ethyl acetate, tetrahydrofuran or methanol under a hydrogen atmosphere in the presence of palladium-carbon, or by reaction with magnesium in methanol. [0293]
Step 3 represents a step of conversion to substituent R2′ when R2 is a hydroxyl-protecting group. Compound (CO4-d) is obtained in the same manner as the continuous treatment in Steps 2 and 3 of Production Process MO. [0294]
Compounds (CO4-b), (CO4-c) and (CO4-d) obtained in this Scheme CO-4 may be converted to the final target compounds by Production Process A. [0295]
Scheme CO-5 is an exemplary synthetic method for phenol and phenoxy derivatives utilizing Friedel-Crafts reaction. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 represents hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl. R3 has the same definition as R6 and R7 in Production Process MO. [0296]
Step 1 represents a step of bromination at the para-position of phenyl. Reaction may be conducted either with bromine in methanol or ethanol or with N-bromosuccinimide in acetonitrile to yield Compound (CO5-a). [0297]
Step 2 represents a step of alkylation by Friedel-Crafts reaction. Compound (CO5-b) is obtained by reaction with alkyl mesylate in benzene or dichloroethane in the presence of scandium triflate, by the method described in H. Katsuki et al., Synthesis 603(1999). [0298]
Step 3 represents a step of introducing a substituent R3 at the hydroxyl group. Compound (CO5-c) is obtained by treatment in the same manner as for introduction of R7 in Step 3 of Production Process MO. [0299]
Compounds (CO5-b) and (CO5-c) obtained in Scheme CO-5 may be converted to the final target compounds by Production Process A. [0300]
Scheme CO-6 is an exemplary synthetic method for carboxylic acid derivatives and benzyl alcohol derivatives. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 represents optionally substituted alkyl and R3 and R4 have the same definitions as R6 and R7 in Production Process MO. [0301]
Step 1 represents a step of introducing a carboxyl group by ortholithiation utilizing the substituent effect of the methoxymethyl group of compound (CA1-b). Compound (CO6-a) is obtained by treating compound (CA1-b) with n-butyllithium in diethyl ether in the presence of tetramethylethylenediamine while cooling on ice, and then reacting it with an alkyl dicarbonate. [0302]
Step 2 represents a step of deprotection of the methoxymethyl group serving as the alcohol-protecting group. Compound (CO6-b) is obtained by reaction with dilute aqueous hydrochloric acid and 10% aqueous perchloric acid in tetrahydrofuran or acetone at room temperature. [0303]
Step 3 represents a step of introducing a substituent R3 at the hydroxyl group. Compound (CO6-c) is obtained by treatment in the same manner as for introduction of R7 in Step 3 of Production Process MO. [0304]
Step 4 represents a step of reduction and alkylation of the carboxyl group. Compound (CO6-d) is obtained by reaction with lithium aluminum hydride in diethyl ether or tetrahydrofuran while cooling on ice, followed by the same method as in Step 3. [0305]
Compounds (CO6-b), (CO6-c) and (CO6-d) obtained in this Scheme CO-6 may be converted to the final target compounds by Production Process A. [0306]
Scheme CO-7 is an exemplary synthetic method for phenethyl alcohol derivatives, phenylacetic acid derivatives and benzofuran derivatives. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 and R3 have the same definitions as R6 and R7 in Production Process MO. R4 and R5 represent optionally substituted alkyl. [0307]
Step 1 represents a step of introducing a hydroxyl group by Wittig reaction followed by hydroboration reaction. The reaction is conducted with methyltriphenylphosphonium bromide in tetrahydrofuran in the presence of potassium tert-butoxide. Reaction is then conducted with borane-tetrahydrofuran in tetrahydrofuran and with 30% aqueous hydrogen peroxide to yield compound (CO[0308] ₇-a).
Step 2 represents a step of introducing a substituent R3 at the hydroxyl group. Compound (CO7-b) is obtained by treatment in the same manner as for introduction of R7 in Step 3 of Production Process MO. [0309]
Step 3 represents a step of carbon-carbon bond formation. Compound (CO7-c) is obtained by reaction with methyl methylthiomethyl sulfoxide in tetrahydrofuran in the presence of Triton B, at the reflux temperature of the solvent, followed by reaction with dilute aqueous hydrochloric acid in methanol or ethanol. [0310]
Step 4 represents a step of oxidation. Compound (CO7-c) is obtained by the method described in Mangzho Zhao et al., Tetrahedron Lett. 39, 5323(1998) or the method described in Ryoji Noyori et al., J. Am. Chem. Soc., 119, 12386(1997). [0311]
Step 5 represents a step of forming a furan ring when R2 is hydrogen. Compound (CO7-d) is obtained by reaction with a bromoacetic acid ester in dimethylformamide in the presence of potassium carbonate, at the reflux temperature of the solvent. [0312]
Compounds (CO7-a), (CO7-b), (CO7-c) and (CO7-d) obtained in this Scheme CO-7 may be converted to the final target compounds by Production Process A. [0313]
Scheme CO-8 is an exemplary synthetic method for 2,3-dihydrobenzofuran derivatives or 2,3-dihydrobenzothiophene derivatives. In the formulas, R1 has the same definition as R1 in Step 1 of Production Process PP. R2 and R3 represent hydrogen, optionally substituted alkyl or optionally substituted alkoxy. [0314]
Step 1 represents a step of alkylation of the hydroxyl group. Compound (CO8-b) is obtained by reaction with an allyl halide, allyl mesylate or allyl tosylate in a solvent such as dimethylformamide, acetonitrile or acetone, in the presence of sodium iodide and in the presence of a base such as potassium carbonate, cesium carbonate or sodium hydride, according to the method described in J. M. Janusz et al., J. Med. Chem. 41, 1112(1998). [0315]
Step 2 represents a step of forming a furan or thiophene ring. Compound (CO8-c) is obtained by the method described in J. M. Janusz et al., J. Med. Chem. 41, 1112(1998), or by reaction at 210° C. in magnesium chloride. [0316]
Step 3 represents a step of Friedel-Craft acylation. Compound (CO8-d) is obtained by reaction with acetyl chloride in methylene chloride or toluene in the presence of a Lewis acid such as aluminum chloride, zinc chloride or tin (II) chloride, at −70° C. to room temperature. [0317]
Step 4 represents a step of bromination by reaction with bromine in methanol or ethanol. Alternatively, compounds (CO8-e) and (CO8-g) are obtained by reaction with N-bromosuccinimide in acetonitrile or dimethylformamide. [0318]
Step 5 represents a step of forming a furan or thiophene ring. Compound (CO8-g) is obtained by reaction with sodium borohydride at 75° C. in dimethylacetamide in the presence of cyclopentadienyldichlorotitanium, by the method described in J. Schwaltz et al., J. Org. Chem. 59, 940(1994). [0319]
Compounds (CO8-d) and (CO8-g) obtained in this Scheme CO-8 may be converted to the final target compounds by Production Process A. [0320]
Scheme CO-9 is an exemplary synthetic method for carboxylic acid derivatives. In the formulas, R1, R2, R3 and R4 represent hydrogen or optionally substituted alkyl. [0321]
Step 1 represents a step of alkylation. Compound (CO9-b) is obtained by reaction with an alkyl halide, mesylate or tosylate in tetrahydrofuran or dimethylformamide, in the presence of potassium tert-butoxide or sodium hydride. [0322]
Step 2 represents a step of reduction. Compound (CO9-c) is obtained by reaction with diisobutylaluminum hydride in tetrahydrofuran. [0323]
Step 3 represents a step of carbon-carbon bond formation utilizing Wittig reaction. The reaction is conducted with a phosphorane derivative in methylene chloride or tetrahydrofuran. Alternatively, compound (CO9-d) is obtained by reaction with either a phosphonium salt or phosphonate in tetrahydrofuran or dimethylformamide in the presence of a base such as potassium tert-butoxide or sodium hydride. [0324]
Compounds (CO9-b) and (CO9-d) obtained in this Scheme CO-9 may be converted to the final target compounds by Production Process A. [0325]
Representative production processes for compounds according to the invention and salts thereof have been described above, but the starting compounds and reagents used for production of the compounds of the invention may also form salts or hydrates, and these are not particularly restricted so long as the reaction is not inhibited. When compound (I) of the invention is obtained as a free compound, a common method may be used to convert it to a salt which compound (I) may form. The different isomers (for example, geometric isomers, optical isomers based on asymmetric carbon, stereoisomers, tautomers or the like) obtained for compound (I) according to the invention may be purified and isolated using common separation means such as recrystallization, diastereomer salt methods, enzymatic resolution methods and chromatography methods (for example, thin-layer chromatography, column chromatography, gas chromatography, etc.). [0326]
In certain embodiments, compounds of the invention represented by formula (I) and salts thereof exhibit excellent thrombin receptor antagonism and especially selective antagonism against PAR1 thrombin receptors. In certain other embodiments, compounds of the invention and their salts also exhibit excellent inhibition against platelet aggregation and smooth muscle cell proliferation, with high oral efficacy. In yet other embodiments, compounds of the invention and salts thereof can therefore inhibit the cellular response to thrombin which includes platelet aggregation, without inhibiting the catalytic activity of thrombin which converts fibrinogen to fibrin, and can also inhibit vascular smooth muscle proliferation occurring as a result of damage to vascular walls by coronary angioplasty and the like, through selective inhibition of PAR1. [0327]
Thus, in certain embodiments, compounds of the invention and salts thereof may be used to obtain pharmaceutical compositions (formulations) as (i) thrombin receptor antagonists (especially PAR1 thrombin receptor antagonists), (ii) platelet aggregation inhibitors, (iii) smooth muscle cell proliferation inhibitors, (iv) endothelial cell, fibroblast, nephrocyte, osteosarcoma cell, muscle cell, cancer cell and/or glia cell proliferation inhibitors and (v) therapeutic or prophylactic agents for thrombosis, vascular restenosis, deep venous thrombosis, pulmonary embolism, cerebral infarction, heart diseases, disseminated intravascular coagulation, hypertension, inflammatory diseases, rheumatism, asthma, glomerulonephritis, osteoporosis, neurological diseases and/or malignant tumors. [0328]
In certain embodiments, compounds of the invention and their salts may be administered for treatment of patients suffering from diseases associated with thrombin receptors, and for treatment of patients suffering from proliferative diseases of, for example, endothelial cell, fibroblast, nephrocyte, osteosarcoma cell, muscle cell, cancer cell and/or glia cell. [0329]
A compound of the invention represented by formula (I) above, a salt thereof or a hydrate of the foregoing may be formulated by a conventional method. Exemplary dosage forms include tablets, powders, fine particles, granules, coated tablets, capsules, syrups, lozenges, inhalants, suppositories, injections, ointments, eye salves, eye drops, nasal drops, ear drops, paps, lotions and the like. Formulations may be prepared with any commonly used excipients, binders, disintegrators, lubricants, coloring agents, corrective coatings, and if necessary, stabilizers, emulsifiers, absorbefacients, surfactants, pH adjustors, preservatives, antioxidants, or the like, in combination with various components that are ordinarily used as materials for pharmaceutical formulations. [0330]
For example, such components include (1) animal and vegetable oils such as soybean oil, beef tallow and synthetic glycerides; (2) hydrocarbons such as liquid paraffin, squalane and solid paraffin; (3) ester oils such as octyldodecyl myristate and isopropyl myristate; (4) higher alcohols such as cetostearyl alcohol and behenyl alcohol; (5) silicone resins; (6) silicone oils; (7) surfactants such as polyoxyethylene fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and polyoxyethylene/polyoxypropylene block copolymer; (8) water-soluble polymers such as hydroxyethylcellulose, polyacrylic acid, carboxyvinyl polymer, polyethylene glycol, polyvinylpyrrolidone and methylcellulose; (9) lower alcohols such as ethanol and isopropanol; (10) polyhydric alcohols such as glycerin, propylene glycol, dipropylene glycol and sorbitol; (11) sugars such as glucose and sucrose; (12) inorganic powders such as silicic anhydride, magnesium aluminum silicate and aluminum silicate; (13) purified water, and the like. [0331]
Examples of (1) excipients which may be used include lactose, corn starch, white soft sugar, glucose, mannitol, sorbit, crystalline cellulose and silicon dioxide; examples of (2) binders which may be used include polyvinyl alcohol, polyvinyl ether, methylcellulose, ethylcellulose, gum arabic, tragacanth, gelatin, shellac, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, polypropylene glycol/polyoxyethylene block polymer, meglumine, calcium citrate, dextrin and pectin; examples of (3) disintegrators which may be used include starch, agar, gelatin powder, crystalline cellulose, calcium carbonate, sodium hydrogencarbonate, calcium citrate, dextrin, pectin and calcium carboxymethylcellulose; examples of (4) lubricants which may be used include magnesium stearate, talc, polyethylene glycol, silica and hydrogenated vegetable oils; examples of (5) coloring agents which may be used include any of those approved for addition to drugs; examples of (6) corrective coatings which may be used include cocoa powder, menthol, aromatic powders, mentha oil, borneol and powdered cinnamon; and examples of (7) antioxidants which may be used include those approved for addition to drugs, such as ascorbic acid, α-tocopherol and the like. [0332]
(i) An oral formulation may be prepared by combining a compound of the invention or its salt with an excipient, if necessary adding a binder, disintegrator, lubricant, coloring agent, corrective coating or the like, and forming a powder, fine particles, granules, tablets, coated tablets, capsules, etc. by a common method. (ii) Tablets or granules may, of course, also be coated with a sugar coating, gelatin coating or other type of suitable coating if necessary. (iii) In the case of a liquid formulation such as syrup, injection, eye drops or the like, a common method may be used for formulation with a pH adjustor, solubilizer, isotonizing agent or the like, as well as a solubilizing aid, stabilizer, buffering agent, suspending agent, antioxidant, etc. if necessary. In the case of a liquid formulation, it may also be lyophilized, and an injection may be administered intravenously, subcutaneously or intramuscularly. As preferred examples of suspending agents there may be mentioned methylcellulose, polysorbate 80, hydroxyethylcellulose, gum arabic, tragacanth powder, sodium carboxymethylcellulose, polyoxyethylene sorbitan monolaurate and the like; as preferred examples of solubilizing aids there may be mentioned polyoxyethylene hydrogenated castor oil, polysorbate 80, nicotinamide, polyoxyethylene sorbitan monolaurate and the like; as preferred examples of stabilizing agents there may be mentioned sodium sulfite, sodium metasulfite, ether and the like; and as preferred examples of preservatives there may be mentioned methyl p-oxybenzoate, ethyl p-oxybenzoate, sorbic acid, phenol, cresol, chlorocresol, and the like. (iv) There are no particular restrictions on the method of preparing an external application, and any common method may be employed. The base materials used may be any raw materials commonly employed in drugs, quasi drugs, cosmetics and the like, and as examples there may be mentioned raw materials such as animal and vegetable oils, mineral oils, ester oils, waxes, higher alcohols, fatty acids, silicone oils, surfactants, phospholipids, alcohols, polyhydric alcohols, water-soluble polymers, clay minerals, purified water and the like, with addition of pH adjustors, antioxidants, chelating agents, antiseptics and fungicides, coloring agents, aromas and the like if necessary. Also, there may be included differentiation-inducing components, or other components such as circulation promoters, microbicides, antiphlogistic agents, cell activators, vitamins, amino acids, humectants, keratolytic agents and the like, as necessary. [0333]
The dosage of a drug according to the invention will differ depending on the patient's severity of symptoms, age, gender and body weight, the dosage form and type of salt, drug sensitivity, the specific type of disease, etc. In certain embodiment, the dosage ranges from about 30 μg to 1000 mg, preferably from 100 μg to 500 mg and more preferably from 100 μg to 100 mg per day for adults in the case of oral administration or about 1-3000 μg/kg and preferably 3-1000 μg/kg per day for adults in the case of injection, administered once or divided over several times a day. [0334]

EXAMPLES

Preferred embodiments of the compounds of the invention represented by formula (I) above and salts thereof will now be explained, with the understanding that the following examples and test examples are only representative and are not intended to be restrictive on the compounds of the invention or salts thereof in any way. It will be apparent to those skilled in the art that the present invention can be carried out with various modifications added beyond these examples, and such modifications are also encompassed within the claims of the present specification. [0335]

Example 1

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-phenyl-ethanone hydrobromide [0336]
(Step 1) 1-Benzyl-1H-benz[d]imidazole-2-amine [0337]
After adding benzyl bromide (16.4 g) and potassium hydroxide (7.6 g) to a solution of 1H-benz[d]imidazole-2-amine (12 g) in ethanol, the mixture was stirred at room temperature for 24 hours. The solvent was distilled off under reduced pressure, and then ethyl acetate was added to the residue and washing was performed with water and brine in that order. After drying the organic layer over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. Diethyl ether was added to the residue and the resulting crystals were filtered off to yield the title compound (14.8 g) as white crystals. [0338]
(Example 1: Final Step) [0339]
After adding 2-bromo-1-phenyl-ethanone(2.7 g) to a solution of 1-benzyl-1H-benz[d]imidazole-2-amine (1.54 g) in dimethylformamide, the mixture was stirred at room temperature for 15 hours. The solvent was distilled off under reduced pressure, and then ethyl acetate was added to the residue and the resulting crystals were filtered off to yield the target compound (1.86 g) as light yellow crystals. [0340]
1H-NMR(DMSO-d6) δ: [0341]
5.55(2H,s), 6.02(2H,s), 7.36-7.46(7H,m), 7.48-7.5(1H,m), 7.63-7.70(3H,m), 7.77(1H,t,J=7.2 Hz), 8.10(2H,d,J=8.4 Hz), 9.04(2H,brs). [0342]
The compounds of the following examples were synthesized by the same method as the final step of Example 1 above, from various 1H-benz[d]imidazole-2-amine derivatives and various 2-bromo-1-ethanone derivatives. [0343]

Example 2

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-fluoro-phenyl)-ethanone hydrobromide [0344]
1H-NMR(DMSO-d6) δ: [0345]
5.54(2H,s), 6.00(2H,s), 7.6-7.55(10H,m), 7.62-7.70(1H,m), 8.17-8.23(2H,m), 9.03(2H,brs). [0346]

Example 3

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-biphenyl-4-yl-ethanone hydrobromide [0347]
1H-NMR(DMSO-d6) δ: [0348]
5.55(2H,s), 6.05(2H,s), 7.27-7.57(11H,m), 7.64-7.7(1H,m), 7.81(2H,d,J=8.4 Hz), 7.97(2H,d,J=8.8 Hz), 8.15-8.22(2H,m), 9.05(2H,brs). [0349]

Example 4

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(4-fluoro-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0350]
1H-NMR(DMSO-d6) δ: [0351]
1.43(18H,s), 5.51(2H,s), 5.96(2H,s), 7.15-7.40(5H,m), 7.52(1H,t,J=4.8 Hz), 7.63(1H,t,J=4.8 Hz), 7.84(2H,s), 7.80-7.87(1H,m), 8.11(1H,brs), 8.96(2H,brs). [0352]

Example 5

2-(3-Biphenyl-4-ylmethyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone trifluoroacetate [0353]
1H-NMR(DMSO-d6) δ: [0354]
1.50(18H,s), 5.56(2H,s), 5.94(2H,s), 7.30-7.48(9H,m), 7.60(2H,d,J=8.4 Hz), 7.67(2H,d,J=8.4 Hz), 8.00(2H,brs). [0355]

Example 6

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-phenyl)-ethanone hydrobromide [0356]
1H-NMR(DMSO-d6) δ: [0357]
5.53(2H,s), 5.90(2H,s), 6.96(2H,d,J=8.0 Hz), 7.38-7.42(7H,m), 7.49(1H,t,J=4.8 Hz), 7.60(1H,t,J=4.8 Hz), 7.96(2H,d,J=8.0 Hz), 8.99(1H,brs), 10.64(1H,brs). [0358]

Example 7

1-Benzyl-3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-1,3-dihydro-benzimidazol-2-one [0359]
1H-NMR(DMSO-d6) δ: [0360]
1.47(18H,s), 5.15(2H,s), 5.45(2H,s), 6.98(4H,m), 7.23(5H,m), 7.95(2H,s). [0361]

Example 8

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-phenyl)-ethanone trifluoroacetate [0362]
1H-NMR(DMSO-d6) δ: [0363]
1.343(18H,s), 5.378(2H,s), 5.86(2H,s), 7.12-7.42(9H,m), 7.77(1H,s), 7.88(2H,s). [0364]

Example 9

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-3,5-dimethyl-phenyl)-ethanone hydrobromide [0365]
1H-NMR(DMSO-d6) δ: [0366]
2.25(6H,s), 5.51(2H,s), 5.88(2H,s), 7.22-7.60(9H,m), 7.72(2H,s), 9.48(1H,s). [0367]

Example 10

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,4-difluoro-phenyl)-ethanone hydrobromide [0368]
1H-NMR(DMSO-d6) δ: [0369]
5.53(2H,s), 5.98(2H,s), 7.14-8.42(12H,m), 9.04(2H,brs). [0370]

Example 11

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-fluoro-phenyl)-ethanone hydrobromide [0371]
1H-NMR(DMSO-d6) δ: [0372]
5.53(2H,s), 6.00(2H,s), 7.17-7.95(12H,m), 8.79(1H,s), 9.04(2H,brs). [0373]

Example 12

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-bromo-phenyl)-ethanone hydrobromide [0374]
1H-NMR(DMSO-d6) δ: [0375]
5.53(2H,s), 6.01(2H,s), 7.25(7H,m), 7.51(1H,dd,J=8.0 Hz,J=3.2 Hz), 7.61(1H,t,J=8.0 Hz), 7.66(1H,dd,J=8.0 Hz,J=3.2 Hz), 7.97(1H,d,J=8.0 Hz), 8.06(1H,d,J=8.0 Hz), 8.25(1H,s), 9.07(2H,s). [0376]

Example 13

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-biphenyl-3-yl-ethanone hydrobromide [0377]
1H-NMR(DMSO-d6) δ: [0378]
5.54(2H,s), 6.10(2H,s), 7.26-7.80(15H,m), 8.02-8.08(2H,m), 8.35(1H,s), 9.03(2H,brs). [0379]

Example 14

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-benzonitrile hydrobromide [0380]
1H-NMR(DMSO-d6) δ: [0381]
5.53(2H,s), 6.03(2H,s), 7.17-7.55(9H,m), 8.14(2H,d,J=8.4 Hz), 8.23(2H,d,J=8.4 Hz), 9.04(2H,brs). [0382]

Example 15

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,4,5-trimethoxy-phenyl)-ethanone hydrobromide [0383]
1H-NMR(DMSO-d6) δ: [0384]
3.77(3H,s), 3.89(6H,s), 5.55(2H,s), 6.05(2H,s), 7.24-7.64(11H,m), 9.06(2H,brs). [0385]

Example 16

2-[3-(4-tert-Butyl-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0386]
1H-NMR(DMSO-d6) δ: [0387]
1.23(9H,s), 1.42(18H,s), 5.47(2H,s), 5.95(2H,s), 7.21(2H,d,J=8.7.2 Hz), 7.22-7.30(2H,m), 3.40(2H,d,J=7.2 Hz), 7.48-7.52(1H,m), 7.56-7.64(1H,m), 7.83(2H,s). [0388]

Example 17

2-[3-(4-Chloro-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0389]
1H-NMR(DMSO-d6) δ: [0390]
1.42(18H,s), 5.52(2H,s), 5.96(2H,s), 7.15-7.87(10H,m), 8.95(2H,brs). [0391]

Example 18

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0392]
1H-NMR(DMSO-d6) δ: [0393]
1.37(9H,s), 5.46(2H,s), 5.84(2H,s), 6.98(1H,d,J=8.0 Hz), 7.15-7.50(10H,m), 7.81-7.88(2H,m). [0394]

Example 19

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-dibutylamino-phenyl)-ethanone hydrobromide [0395]
1H-NMR(DMSO-d6) δ: [0396]
0.92(6H,t,J=6.5 Hz), 1.25-1.56(8H,m), 3.37(4H,brt), 5.51(2H,s), 5.92(2H,s), 6.75(2H,d,J=9.0 Hz), 7.21-7.58(9H,m), 7.86(2H,d,J=9.0 Hz), 8.98(2H,s). [0397]

Example 20

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-3,5-diisopropyl-phenyl)-ethanone hydrobromide [0398]
1H-NMR(DMSO-d6) δ: [0399]
1.19(12H,d,J=8.0 Hz), 3.25-3.40(2H,m), 5.38(2H,s), 5.78(2H,s), 7.1-7.43(9H,m), 7.73(2H,s). [0400]

Example 21

N,N-Dibenzyl-2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetamide hydrobromide [0401]
1H-NMR(DMSO-d6) δ: [0402]
4.50(2H,s), 4.66(2H,s), 5.40(2H,s), 5.52(2H,s), 7.18-7.50(19H,m), 9.16(2H,s). [0403]

Example 22

2-(3-Benzyl-2-methylimino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone trifluoroacetate [0404]
1H-NMR(DMSO-d6) δ: [0405]
1.43(18H,s), 3.02(3H,s), 5.71(2H,s), 6.05(2H,s), 7.20-7.45(7H,m), 7.52-7.58(1H,m), 7.66-7.71(1H,m), 8.13(2H,s). [0406]

Example 23

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-methoxy-1H-indol-3-yl)-ethanone hydrobromide [0407]
1H-NMR(DMSO-d6) δ: [0408]
3.72(3H,s), 5.54(2H,s), 5.78(2H,s), 6.87(1H,dd,J=8.8 Hz,J=2.0 Hz), 7.25-5.58(11H), 8.56(1H,d,J=1.6 Hz), 9.02(2H,brs), 12.17(1H,s). [0409]

Example 24

Methyl 5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-hydroxy-benzoate hydrobromide [0410]
1H-NMR(DMSO-d6) δ: [0411]
3.92(3H,s), 5.54(2H,s), 5.99(2H,s), 7.15-7.68(10H,m), 8.10-8.18(1H,m), 3.39-8.47(1H,m), 9.04(2H,brs), 11.23(1H,brs). [0412]

Example 25

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-pyridin-4-ylmethyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0413]
1H-NMR(DMSO-d6) δ: [0414]
1.426(18H,s), 5.582(2H,s), 5.957(2H,s), 7.107(2H,d,J=6.4 Hz), 7.26-7.65(4H,m), 7.829(2H,s), 8.583(2H,dd,J=4.4, 1.6 Hz). [0415]

Example 26

Ethyl 4-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzoate hydrobromide [0416]
1H-NMR(DMSO-d6) δ: [0417]
1.28(3H,t,J=6.5 Hz), 1.41(18H,s), 4.28(2H,q,J=6.5 Hz), 5.58(2H,s), 5.90(2H,brs), 7.20-8.00(10H,m). [0418]

Example 27

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzoic acid hydrochloride [0419]
1H-NMR(DMSO-d6) δ: [0420]
1.429(18H,s), 5.65(2H,s), 6.01(2H,s), 7.22-7.66(6H,m), 7.85(2H,s), 7.86-8.18(3H,m), 9.14(2H,brs). [0421]

Example 28

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(3-phenyl-propyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0422]
1H-NMR(DMSO-d6) δ: [0423]
1.422(18H,s), 1.90-2.08(2H,m), 2.57-2.73(2H,m), 4.27(2H,t,J=7.0 Hz), 5.92(2H,s), 7.10-7.65(9H,m), 7.83(2H,s), 8.80(2H,brs). [0424]

Example 29

2-(3-Cyclohexylmethyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0425]
1H-NMR(DMSO-d6) δ: [0426]
0.95-1.95(29H,m), 4.05(2H,d,J=8.0 Hz), 5.93(2H,s), 7.22-7.37(2H,m), 7.58(1H,d,J=7.0 Hz), 7.65(1H,d,J=7.0 Hz), 7.81(2H,s), 8.71(2H,brs) [0427]

Example 30

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-hydroxy-benzoic acid hydrobromide [0428]
1H-NMR(DMSO-d6) δ: [0429]
5.52(2H,s), 5.97(2H,s), 7.06(1H,d,J=8.0 Hz), 7.44-7.67(9H,m), 8.08(1H,d,J=8.0 Hz), 8.51(1H,s), 8.99(2H,brs). [0430]

Example 31

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzamide hydrobromide [0431]
1H-NMR(DMSO-d6) δ: [0432]
1.434(18H,s), 5.57(2H,s), 5.98(2H,s), 7.24-7.37(4H,m), 7.40(1H,brs), 7.45-7.91(6H,m), 7.96(1H,brs), 8.12(1H,s), 8.99(2H,s). [0433]

Example 32

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-pyridin-2-ylmethyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0434]
1H-NMR(DMSO-d6) δ: [0435]
1.433(18H,s), 5.62(2H,s), 5.96(2H,s), 7.21-7.90(9H,m), 8.10(1H,brs), 8.50(1H,brd,J=6.0 Hz), 8.91(2H,brs). [0436]

Example 33

2-(3-Benzenesulfonyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0437]
1H-NMR(DMSO-d6) δ: [0438]
1.421(18H,s), 5.85(2H,s), 6.85-8.00(11H,m). [0439]

Example 34

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-thiazol-2-ylmethyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0440]
1H-NMR(DMSO-d6) δ: [0441]
1.43(18H,s), 5.90(2H,s), 5.94(2H,s), 7.05-7.90(8H,m), 9.04(2H,brs). [0442]

Example 35

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-pyridin-3-ylmethyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0443]
1H-NMR(DMSO-d6) δ: [0444]
1.43(18H,s), 5.59(2H,s), 5.96(2H,s), 7.25-7.54(3H,m), 7.56(1H,d,J=6.0 Hz), 7.65(1H,d,J=6.0 Hz), 7.72(1H,d,J=6.0 Hz), 7.84(2H,s), 8.12(1H,s), 8.54-8.62(2H,m), 9.03(2H,s). [0549) [0445]

Example 36

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(1-phenyl-ethyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0446]
1H-NMR(DMSO-d6) δ: [0447]
1.44(18H,s), 1.98(3H,d.J=7.6 Hz), 5.88-6.10(3H,m), 6.95-7.65(10H,m), 7.85(2H,s), 8.06-8.16(1H,m), 8.85-8.97(1H,m). [0448]

Example 37

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(2-methyl-benzyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0449]
1H-NMR(DMSO-d6) δ: [0450]
1.44(18H,s), 2.40(3H,s), 5.57(2H,brs), 5.95-6.03(1H,m), 6.54-6.60(1H,m), 7.09-7.69(10H,m), 7.84(2H,s). [0451]

Example 38

N-Butyl-2-{(3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-2-phenyl-acetamide hydrobromide [0452]
1H-NMR(DMSO-d6) δ: [0453]
0.86(3H,t,J=6.8 Hz), 1.20-1.33(2H,m), 1.36-1.53(20H,m), 3.14-3.40(2H,m), 6.39-6.08(2H,m), 6.63(1H,s), 7.13-7.49(8H,m), 7.62(1H,s), 7.84(2H,s), 8.10(1H,brs), 8.77-8.84(1H,m), 8.96-9.05(2H,m). [0454]

Example 39

2-[3-(2-Amino-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone dihydrochloride [0455]
1H-NMR(DMSO-d6) δ: [0456]
1.42(18H,s), 5.62(2H,s), 6.07(2H,s), 7.65-7.68(8H,m), 7.86(2H,s), 8.11(1H,s). [0457]

Example 40

2-[3-(4-Amino-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone dihydrochloride [0458]
1H-NMR(DMSO-d6) δ: [0459]
1.431(18H,s), 5.35(2H,s), 5.94(2H,s), 6.69(2H,d,J=8.0 Hz), 7.10(2H,d,J=6.0 Hz), 7.22-7.64(4H,m), 7.95(2H,s), 8.11(1H,s), 8.91(2H,brs). [0460]

Example 41

Ethyl 3-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzoate hydrobromide [0461]
1H-NMR(DMSO-d6) δ: [0462]
1.302 (3H, t,J=6.5 Hz), 1.432 (18H, s), 4.30 (2H, q, J=6.5 Hz), 5.62(2H,s), 5.98(2H,s), 7.28(2H,d,J=8.0 Hz), 7.48-7.60(3H,m), 7.65(1H,t,J=5.5 Hz), 7.86(2H,s), 7.93(1H,d,J=5.5 Hz), 7.96(1H,s), 9.00(2H, brs) [0463]

Example 42

3-[3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl]-benzoic acid hydrochloride [0464]
1H-NMR(DMSO-d6) δ: [0465]
1.429(18H,s), 5.71(2H,s), 6.14(2H,s), 7.20-7.56(5H,m), 7.59(1H,d,J=9.0 Hz), 7.85(2H,s), 7.89(1H,d,J=9.0 Hz), 7.95(1H,s), 8.09(1H,s), 9.45(2H,brs). [0466]

Example 43

3-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzamide [0467]
1H-NMR(DMSO-d6) δ: [0468]
1.423(18H,s), 5.56(2H,s), 5.95(2H,s), 7.20-7.85(10H,m), 7.88(1H,s), 8.00(1H,s). [0469]

Example 44

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(1-phenyl-heptyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0470]
1H-NMR(DMSO-d6) δ: [0471]
0.82(3H,t,J=6.8 Hz), 1.02-1.53(28H,m), 5.83-5.93(2H,m), 5.99(2H,s), 7.04-7.65(9H,m), 7.82(2H,s), 8.08-8.12(1H,m), 8.87-9.00(2H,m). [0472]

Example 45

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-quinolin-2-ylmethyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0473]
1H-NMR(DMSO-d6) δ: [0474]
1.429(18H,s), 5.83(2H,s), 6.03(2H,s), 7.10-7.78(7H,m), 7.84(2H,s), 7.95(1H,d,J=9.0 Hz), 8.43(1H,d,J=9.0 Hz), 8.94(1H,brs). [0475]

Example 46

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzenesulfonamide hydrobromide [0476]
1H-NMR(DMSO-d6) δ: [0477]
1.437(18H,s), 5.63(2H,s), 5.99(2H,s), 7.20-7.90(12H,m), 8.13(1H,s), 9.03(2H,s). [0478]

Example 47

1-Benzyl-3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-1H-benzimidazole-5-carboxamide hydrobromide [0479]
1H-NMR(DMSO-d6) δ: [0480]
1.43(18H,s), 5.56(2H,s), 6.04(2H,brs), 7.20-7.47(6H,m), 7.56(1H,d,J=8.4 Hz), 7.81(1H,d,J=8.4 Hz), 7.86(2H,s), 7.93(1H,brs), 8.12(2H,brs), 9.06-9.21(2H,m). [0481]

Example 48

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(3-heptyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0482]
1H-NMR(DMSO-d6) δ: [0483]
0.84(3H,t,J=7.6 Hz), 1.14-1.49(28H,m), 1.63-1.74(2H,m), 4.15-4.26(2H,m), 5.96(2H.brs), 7.27(1H,dd,J=7.6 and 7.6 Hz), 7.33(1H,dd,J=7.6 and 7.6 Hz), 7.59(1H,d,J=7.6 Hz), 7.63(1H,d,J=7.6 Hz), 7.83(2H,s), 8.03-8.18(1H,m), 8.69-8.86(2H,m). [0484]

Example 49

2-(1-Benzyl-2-imino-1,2-dihydro-imidazo[4,5-c]pyridin-3-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0485]
1H-NMR(DMSO-d6) δ: [0486]
1.41(18H,s), 5.48(2H,s), 6.23(2H,s), 7.21-7.40(5H,m), 7.77(2H,s), 7.84(1H,d,J=6.8 Hz), 7.91(1H,s), 8.15(1H,s), 8.26(1H,d,J=6.8 Hz), 8.67(2H,brs). [0487]

Example 50

2-[3-(3-Amino-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone dihydrochloride [0488]
1H-NMR(DMSO-d6) δ: [0489]
1.428(18H,s), 5.63(2H,s), 6.10(2H,s), 7.08-7.64(9H,m), 7.85(2H,s), 8.10(1H,s), 9.34(2H,brs). [0490]

Example 51

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(4-hydroxy-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrochloride [0491]
1H-NMR(DMSO-d6) δ: [0492]
1.431(18H,s), 5.36(2H,s), 5.84(2H,s), 6.75(2H,d,J=9.5 Hz), 7.15(2H,d,J=9.5 Hz), 7.21-7.64(4H,m), 7.83(2H,s), 8.12(2H,s), 8.94(2H,s). [0493]

Example 52

1-Benzyl-3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-1H-benzimidazole-5-carboxylic acid hydrochloride [0494]
1H-NMR(DMSO-d6) δ: [0495]
1.43(18H,s), 5.63(2H,s), 6.20(2H,brs), 7.25-7.42(5H,m), 7.58(1H,d,J=8.4 Hz), 7.86(2H,s), 7.89(1H,d,J=8.4 Hz), 8.11(1H,s), 8.20(1H,s), 9.45-9.54(2H,m). [0496]

Example 53

Ethyl 4-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-butyrate hydrobromide [0497]
1H-NMR(DMSO-d6) 6: [0498]
1.13(3H,t,J=7.2 Hz), 1.43(18H,s), 1.86-2.02(2H,m), 2.37-2.51(2H,m), 4.01(2H,q,J=7.2 Hz), 4.16-4.31(2H,m), 5.97(2H,brs), 7.28(1H,dd,J=8.0 and 8.0 Hz), 7.34(1H,dd,J=8.0 and 8.0 Hz), 7.60(1H,d,J=8.0 Hz), 7.65(1H,d,J=8.0 Hz), 7.84(2H,s), 8.02-8.15(1H,m), 8.73-8.95(2H,m). [0499]

Example 54

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(6-hydroxy-hexyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0500]
1H-NMR(DMSO-d6) δ: [0501]
1.22-1.54(24H,m), 1.61-1.74(2H,m), 3.25-3.40(2H,m), 4.14-4.25(2H,m), 4.30-4.38(1H,m), 5.93(2H,s), 7.27(1H,d,J=8.0 and 8.0 Hz), 7.33(1H,d,J=8.0 and 8.0 Hz), 7.59(1H,d,J=8.0 Hz), 7.63(1H,d,J=8.0 Hz), 7.83(2H,s), 8.68-8.82(3H,m). [0502]

Example 55

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-butyric acid hydrochloride [0503]
1H-NMR(DMSO-d6) δ: [0504]
1.42(18H,s), 1.87-1.97(2H,m), 2.32-2.39(2H,m), 4.20-4.32(2H,m), 5.94-6.05(2H,m), 7.26(1H,dd,J=8.0 and 8.0 Hz), 7.33(1H,dd,J=8.0 and 8.0 Hz), 7.57(1H,d,J=8.0 Hz), 7.62(1H,d,J=8.0 Hz), 7.83(2H,s), 8.10(1H,s), 8.99-9.17(2H,m). [0505]

Example 56

6-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-hexanoic acid hydrochloride [0506]
1H-NMR(DMSO-d6) δ: [0507]
1.31-1.48(20H,m), 1.49-1.59(2H,m), 1.65-1.74(2H,m), 2.20(2H,t,J=7.6 Hz), 4.15-4.24(2H,m), 5.96(2H,brs), 7.27(1H,dd,J=8.0 and 8.0 Hz), 7.33(1H,dd,J=8.0 and 8.0 Hz), 7.57(1H,d,J=8.0 Hz), 7.63(1H,d,J=8.0 Hz), 7.83(2H,s), 8.09(1H,s), 8.80-8.93(2H,bm). [0508]

Example 57

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-N-ethyl-butylamide hydrobromide [0509]
1H-NMR(DMSO-d6) δ: [0510]
1.10(3H,t,J=7.2 Hz), 1.43(18H,s), 1.74-1.83(2H,m), 2.17-2.29(2H,m), 3.10-3.22(2H,m), 3.55(2H,t,J=7.2 Hz), 4.80-5.02(2H,m), 7.12-7.64(6H,m), 7.97(2H,s). [0511]

Example 58

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-{2-imino-3-[3-(tetrahydropyran-2-yloxy)-propyl]-2,3-dihydro-benzimidazol-1-yl}-ethanone hydrobromide [0512]
1H-NMR(DMSO-d6) δ: [0513]
1.27-1.70(24H,m), 1.90-2.03(2H,m), 3.23-3.42(2H,m), 3.52-3.55(2H,m), 4.21-4.37(2H,m), 4.41-4.48(1H,m), 5.88-5.99(2H,m), 7.27(1H,dd,J=8.0 and 8.0 Hz), 7.33(1H,dd,J=8.0 and 8.0 Hz), 7.54-7.63(2H,m), 7.85(2H,s), 8.03-8.15(1H,m), 8.72-8.85(2H,m). [0514]

Example 59

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(3-hydroxy-propyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0515]
1H-NMR(DMSO-d6) δ: [0516]
1.43(18H,s), 1.82-1.92(2H,m), 3.40-3.52(2H,m), 4.20-4.34(2H,m), 5.89-6.02(2H,m), 7.18-7.39(2H,m), 7.54-7.65(2H,m), 7.84(2H,s), 8.69-8.87(2H,m). [0517]

Example 60

2-(3-Benzyl-6-hydroxymethyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0518]
1H-NMR(DMSO-d6) δ: [0519]
1.43(18H,s), 4.50(2H,d,J=5.2 Hz), 5.26(1H,t,J=5.2 Hz), 5.52(2H,s), 5.94-6.04(2H,m), 7.14-7.43(8H,m), 7.58(1H,s), 7.85(2H,s), 8.78-9.00(2H,m). [0520]

Example 61

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethyl]-2,6-di-tert-butyl-phenol hydrochloride [0521]
1H-NMR(DMSO-d6) δ: [0522]
1.195(18H,s), 2.92(2H,t,J=5.5 Hz), 4.43(2H,t,J=5.5 Hz), 5.45(2H,s), 6.69(1H,s), 6.77(2H,s), 7.02-7.40(9H,m), 9.13(2H,s). [0523]

Example 62

Benzyl (2-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-ethyl)-carbamate hydrobromide [0524]
1H-NMR(DMSO-d6) δ: [0525]
1.42(18H,s), 3.37-3.47(2H,m), 4.22-4.31(2H,m), 4.86(2H,s), 5.92(2H,brs), 7.12-7.59(9H,m), 7.83(2H,s), 8.10(1H,s), 8.79(2H,brs). [0526]

Example 63

2-[3-(2-Amino-ethyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0527]
1H-NMR(DMSO-d6) δ: [0528]
1.42(18H,s), 2.94-3.03(2H,m), 4.14-4.26(2H,m), 5.82(2H,s), 7.19-7.32(2H,m), 7.45-7.62(2H,m), 7.77(2H,s). [0529]

Example 64

3-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-N-propyl-propionamide hydrobromide [0530]
1H-NMR(DMSO-d6) δ: [0531]
0.86(3H,t,J=7.6 Hz), 1.22-1.36(2H,m), 1.42(18H,s), 2.61(2H,t,J=7.2 Hz), 2.90-2.98(2H,m), 4.41(2H,t,J=7.2 Hz), 5.89(2H,brs), 7.22-7.34(2H,m), 7.51-7.62(2H,m), 7.81(2H,s). [0532]

Example 65

3-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-propionamide hydrobromide [0533]
1H-NMR(DMSO-d6) δ: [0534]
1.43(18H,s), 2.62(2H,t,J=7.2 Hz), 4.38(2H,t,J=7.2 Hz), 5.90(2H,brs), 7.10(1H,brs), 7.22-7.35(2H,m), 7.51-7.66(3H,m), 7.83(2H,s), 8.12(1H,brs), 8.73-8.82(2H,m). [0535]

Example 66

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(4-dimethylamino-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone dihydrochloride [0536]
1H-NMR(DMSO-d6) δ: [0537]
1.429(18H,s), 2.86(6H,s), 5.37(2H,s), 5.93(2H,s), 6.72(2H,d,J=8.4 Hz), 7.20(2H,d,J=8.4 Hz), 7.22-7.62(4H,m), 7.83(2H,s), 8.11(1H,brs), 8.93(2H,brs). [0538]

Example 67

2-[3-(4-Aminomethyl-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone dihydrochloride [0539]
1H-NMR(DMSO-d6) δ: [0540]
1.430(18H,s), 3.98(2H,brs), 5.62(2H,s), 6.06(2H,s), 7.22-7.30(2H,m), 7.36(2H,d,J=7.9 Hz), 7.43-7.63(4H,m), 7.84(2H,s), 8.11(1H,s), 8.39(3H,brs), 9.31(2H,brs). [0541]

Example 68

Ethyl (4-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenylamino)-acetate dihydrochloride [0542]
1H-NMR(DMSO-d6) δ: [0543]
1.15(3H,t,J=6.8 Hz), 1.428(18,s), 3.85(2H,s), 4.07(2H,q,J=6.8 Hz), 5.33(2H,s), 5.97(2H,s), 6.53(2H,d,J=8.2 Hz), 7.10(2H,d,J=8.2 Hz), 7.18-7.60(4H,m), 7.83(2H,s), 8.10(1H,s), 9.02(2H,s). [0544]

Example 69

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2,2,5,7,8-pentamethyl-chroman-6-yl)-ethanone hydrobromide [0545]
1H-NMR(DMSO-d6) δ: [0546]
1.25(6H,s), 1.78(2H,t,J=10 Hz), 2.03(3H,s), 2.10(3H,s), 2.13(3H,s), 2.58(2H,t,J=10 Hz), 5.55(2H,s), 5.70(2H,s), 7.30-7.55(9H,m), 9.05(2H,s). [0547]

Example 70

(4-{3-(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenylamino)-acetic acid hydrochloride [0548]
1H-NMR(DMSO-d6) δ: [0549]
1.429(18H,s), 3.75(2H,s), 5.31(2H,s), 5.94(2H,brs), 6.53(2H,d,J=8.8 Hz), 7.09(2H,d,J=8.8 Hz), 7.20-7.62(4H,m), 7.835(2H,s), 8.11(1H,s), 8.91(2H,brs). [0550]

Example 71

2-(4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenylamino)-acetamide dihydrochloride [0551]
1H-NMR(DMSO-d6) δ: [0552]
1.429(18H,s), 5.32(2H,s), 5.94(2H,brs), 6.51(2H,d,J=8.2 Hz), 7.06(1H,brs), 7.11(2H,d,J=8.2 Hz), 7.21-7.30(2H,m), 7.32(1H,brs), 7.51-7.62(2H,m), 7.83(2H,s), 8.11(1H,brs), 8.92(2H,brs). [0553]

Example 72

2-[3-(4-Amino-cyclohexylmethyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone dihydrochloride [0554]
1H-NMR(DMSO-d6) δ: [0555]
1.35-2.14(27H,m), 4.11(2H,d,J=7.3 Hz), 5.94(2H,s), 7.28(1H,dd,J=8.0 Hz), 7.34(1H,dd,J=8.0 Hz), 7.58(1H,d,J=8.0 Hz), 7.61(1H,d,J=8.0 Hz), 7.82(2H,s), 7.86(2H,brs), 8.10(1H,s), 8.81(2H,brs). [0556]

Example 73

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2′-hydroxy-[1,1′:3′,1,″]terphenyl-5′-yl)-ethanone hydrobromide [0557]
1H-NMR(DMSO-d6) δ: [0558]
5.33(2H,s), 5.85(2H,s), 6.85-6.93(1H,m), 7.00-7.08(1H,m), 7.12-7.24(7H,m), 7.40-7.60(10H,m), 7.90(2H,s). [0559]

Example 74

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-sec-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0560]
1H-NMR(DMSO-d6) δ: [0561]
0.80(6H,t,J=9.0 Hz), 1.18(6H,d,J=9.5 Hz), 1.45-1.68(4H,m), 2.75-2.90(2H,m), 5.32(2H,s), 5.85(2H,s), 6.88-7.23(9H,m), 7.65(2H,s). [0562]

Example 75

Ethyl (4-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-acetate hydrobromide [0563]
1H-NMR(DMSO-d6) δ: [0564]
1.22(3H,t,J=7.1 Hz), 1.482(18H,s), 3.53(2H,s), 4.11(2H,q,J=7.1 Hz), 5.70(2H,s), 5.87(1H,s), 6.32(2H,brs), 7.01(1H,dd,J=6.2, 3.1 Hz), 7.10-7.30(7H,m), 7.97(2H,s), 9.12(2H,brs) [0565]

Example 76

(4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-acetic acid hydrochloride [0566]
1H-NMR(DMSO-d6) δ: [0567]
1.432(18H,s), 3.54(2H,s), 5.53(2H,s), 6.02(2H,s), 7.10-7.68(8H,m), 7.85(2H,s), 8.09(1H,s), 9.12(2H,brs). [0568]

Example 77

2-[3-(6-Amino-pyridin-3-ylmethyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone dihydrochloride [0569]
1H-NMR(DMSO-d6) δ: [0570]
1.43(18H,s), 5.40(2H,s), 5.96(2H,s), 6.99(1H,d,J=8.8 Hz), 7.24-7.69(4H,m), 7.78(1H,dd,J=8.8, 1.5 Hz), 7.829(2H,s), 8.03(1H,s), 8.12(1H,brs), 9.09(2H,brs). [0571]

Example 78

Ethyl 4-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-cyclohexanecarboxylate hydrobromide [0572]
1H-NMR(DMSO-d6) δ: [0573]
1.145(3H,t,J=6.9 Hz), 1.10-1.35(3H,m), 1.426(18H,s), 1.60-2.27(6H,m), 4.07(2H,brd,J=6.2 Hz), 5.92(2H,s), 7.27(1H,t,J=7.8 Hz), 7.32(1H,t,J=7.8 Hz), 7.59(1H,d,J=7.8 Hz), 7.65(1H,d,J=7.8 Hz), 7.826(2H,s), 8.10(1H,s), 8.77(2H,s). [0574]

Example 79

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-cyclohexanecarboxylic acid hydrochloride [0575]
1H-NMR(DMSO-d6) δ: [0576]
1.03-1.33(4H,m), 1.429(18H,s), 1.55-2.19(5H,m), 4.09(2H,brd,J=7.1 Hz), 5.97(2H,brs), 7.26(1H,t,J=7.9 Hz), 7.32(1H,t,J=7.9 Hz), 7.57(1H,d,J=7.9 Hz), 7.65(1H,d,J=7.9 Hz), 7.831(2H,s), 8.09(1H,s), 8.89(2H,brs). [0577]

Example 80

4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-cyclohexanecarboxamide hydrochloride [0578]
1H-NMR(DMSO-d6) δ: [0579]
1.10-2.09(28H,m), 4.12(2H,brd,J=7.2 Hz), 6.02(2H,s), 6.66(1H,brs), 7.14-7.37(3H,m), 7.56(1H,d,J=7.6 Hz), 7.64(1H,d,J=7.6 Hz), 7.83(2H,s), 8.08(1H,brs), 9.03(2H,brs). [0580]

Example 81

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrochloride [0581]
1H-NMR(DMSO-d6) δ: [0582]
1.42(18H,s), 5.90(2H,s), 7.14-7.57(4H,m), 7.83(2H,s), 8.07(1H,brs), 8.65(2H,brs). [0583]

Example 82

Ethyl 2-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzoate hydrobromide [0584]
1H-NMR(DMSO-d6) δ: [0585]
1.38(3H,t,J=7.1 Hz), 1.438(18H,s), 4.39(2H,q,J=7.1 Hz), 5.839(2H,s), 6.007(2H,brs), 6.719(1H,d,J=8.0 Hz), 7.254(1H,t,J=7.2 Hz), 7.304(1H,t,J=7.2 Hz), 7.45(1H,d,J=7.2 Hz), 7.489(1H,d,J=7.2 Hz), 7.544(1H,t,J=7.2 Hz), 7.67(1H,d,J=8.4 Hz), 7.860(2H,s), 8.05-8.15(2H,m), 8.921(2H,brs). [0586]

Example 83

2-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzoic acid hydrochloride [0587]
1H-NMR(DMSO-d6) δ: [0588]
1.42(18H,s), 5.86(2H,s), 6.02(2H,s), 6.69(1H,d,J=8.1 Hz), 7.25(1H,t,J=7.6 Hz), 7.30(1H,t,J=7.6 Hz), 7.40-7.48(2H,m), 7.53(1H,t,J=8.1 Hz), 7.67(1H,d,J=7.6 Hz), 7.859(2H,s), 8.04-8.16(2H,m), 8.94(2H,brs). [0589]

Example 84

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(3-ethyl-pentyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0590]
1H-NMR(DMSO-d6) 6: [0591]
0.82(6H,t,J=7.0 Hz), 1.21-1.68(25H,m), 4.23(2H,brt,J=7.5 Hz), 5.82(2H,s), 7.28(1H,t,J=7.7 Hz), 7.35(1H,t,J=7.7 Hz), 7.56(1H,d,J=7.7 Hz), 7.59(1H,d,J=7.7 Hz), 7.829(2H,s), 8.75(2H,brs). [0592]

Example 85

Ethyl 3-(4-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-propanoate hydrobromide [0593]
1H-NMR(DMSO-d6) δ: [0594]
1.11(3H,t,J=7.0 Hz), 1.433(18H,s), 2.57(2H,t,J=7.9 Hz), 2.82(2H,t,J=7.9 Hz), 2.00(2H,q,J=7.0 Hz), 5.46(2H,s), 6.96(2H,s), 7.15-7.66(8H,m), 7.842(2H,s), 8.12(1H,brs), 8.95(2H,brs). [0595]

Example 86

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2-fluoro-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0596]
1H-NMR(DMSO-d6) δ: [0597]
1.43(18H,s), 5.61(2H,s), 6.00(2H,s), 7.12(1H,t,J=7.9 Hz), 7.21(1H,t,J=7.9 Hz), 7.24-7.68(6H,m), 7.85(2H,s), 8.11(1H,brs), 8.98(2H,brs). [0598]

Example 87

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-dichloro-4-hydroxy-phenyl)-ethanone hydrobromide [0599]
1H-NMR(DMSO-d6) δ: [0600]
5.50(2H,s), 5.73(2H,s), 7.15-7.57(9H,m), 7.70(2H,s), 9.03(2H,s). [0601]

Example 88

3-(4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-propanoic acid hydrochloride [0602]
1H-NMR(DMSO-d6) δ: [0603]
1.434(18H,s), 2.46-2.53(2H,m), 2.78(2H,t,J=7.5 Hz), 5.47(2H,s), 5.96(2H,s), 7.14-7.66(8H,m), 7.843(2H,s), 8.11(1H,s), 8.94(2H,brs). [0604]

Example 89

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(2-methoxy-benzyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0605]
1H-NMR(DMSO-d6) δ: [0606]
1.44(18H,s), 3.83(3H,s), 5.41(2H,s), 5.97(2H,s), 6.93(1H,t,J=7.4 Hz), 6.80-7.05(2H,m), 7.09(1H,d,J=8.8 Hz), 7.20-7.65(5H,m), 7.85(2H,s), 8.12(1H,s), 8.89(2H,brs). [0607]

Example 90

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(2-trifluoromethyl-benzyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0608]
1H-NMR(DMSO-d6) δ: [0609]
1.43(18H,s), 5.67(2H,s), 6.04(2H,s), 6.92(1H,d,J=7.4 Hz), 7.12(1H,d,J=8.1 Hz), 7.25(1H,t,J=8.1 Hz), 7.30(1H,t,J=8.1 Hz), 7.57(1H,d,J=7.4 Hz), 7.62-7.94(6H,m), 8.14(1H,brs), 9.07(2H,brs). [0610]

Example 91

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2,5-dimethoxy-3,4,6-trimethyl-phenyl)-ethanone hydrobromide [0611]
1H-NMR(DMSO-d6) δ: [0612]
2.10(3H,s), 2.16(3H,s), 2.18(3H,s), 3.60(6H,s), 5.56(2H,s), 5.67(2H,s), 7.25-7.55(9H,m), 9.13(2H,s). [0613]

Example 92

1-(4-Benzhydryl-piperazin-1-yl)-2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0614]
1H-NMR(DMSO-d6) δ: [0615]
2.28-2.36(2H,m), 2.40-2.52(2H,m), 3.42-3.50(2H,m), 3.51-3.60(2H,m), 4.38(1H,s), 5.25(2H,s), 5.50(2H,s), 7.17-7.56(19H,m), 9.03(2H,brs). [0616]

Example 93

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-hydroxy-ethyl]-2,6-di-tert-butyl-phenol trifluoroacetate [0617]
1H-NMR(DMSO-d6) δ: [0618]
1.27(18H,s), 4.27-4.43(2H,m), 4.91(1H,t,J=2.8 Hz), 5.45(2H,s), 6.84(1H,brs), 7.09(2H,s), 7.07-7.40(9H,m). [0619]

Example 94

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-methoxy-ethyl]-2,6-di-tert-butyl-phenol trifluoroacetate [0620]
1H-NMR(DMSO-d6) δ: [0621]
1.25(18H,s), 3.09(3H,s), 4.34-4.62(3H,m), 5.47(2H,s), 6.99(2H,s), 7.10-7.54(9H,m), 9.09(2H,brs). [0622]

Example 95

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-3,5-dimethoxy-phenyl)-ethanone hydrobromide [0623]
1H-NMR(DMSO-d6) δ: [0624]
3.87(6H,s), 5.54(2H,s), 5.99(2H,s), 7.28-7.42(9H,m), 7.49-7.51(1H,m), 7.58-7.60(1H,m), 9.03(2H,s). [0625]

Example 96

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2,3-dimethoxy-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0626]
1H-NMR(DMSO-d6) δ: [0627]
1.44(18H,s), 3.784(3H,s), 3.808(3H,s), 5.46(2H,s), 5.98(2H,s), 6.55-7.67(7H,m), 7.85(2H,s), 8.91(2H,brs). [0628]

Example 97

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2,6-dimethoxy-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0629]
1H-NMR(DMSO-d6) δ: [0630]
1.44(18H,s), 3.84(6H,s), 5.32(2H,s), 5.91(2H,s), 6.73(2H,d,J=8.3 Hz), 7.13-7.27(3H,m), 7.33(1H,t,J=8.3 Hz), 7.46-7.56(1H,m), 7.83(2H,s), 8.10(1H,s), 8.77(2H,brs). [0631]

Example 98

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2-ethoxy-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0632]
1H-NMR(DMSO-d6) δ: [0633]
1.33(3H,t,J=7.0 Hz), 1.43(18H,s), 4.08(2H,q,J=7.0 Hz), 5.41(2H,s), 5.96(2H,s), 6.93(1H,t,J=7.6 Hz), 7.05(1H,d,J=7.6 Hz), 7.12(1H,d,J=7.6 Hz), 7.17-7.63(4H,m), 7.846(2H,s), 8.09(1H,s), 8.95(2H,brs). [0634]

Example 99

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-N-(3,5-di-tert-butyl-4-hydroxy-phenyl)-acetamide hydrochloride [0635]
1H-NMR(DMSO-d6) δ: [0636]
5.19(2H,s), 5.53(2H,s), 6.84(1H,s), 7.26-7.37(7H,m), 7.46(1H,d,J=8.0 Hz), 7.54(1H,d,J=8.0 Hz), 9.18(2H,brs), 10.34(1H,s) [0637]

Example 100

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-7-tert-butyl-3,3-dimethyl-3H-benzofuran-2-one hydrobromide [0638]
1H-NMR(DMSO-d6) δ: [0639]
1.41(9H,s), 1.52(6H,s), 5.52(2H,s), 6.00(2H,s), 7.20-7.67(9H,m), 7.94(1H,s), 8.14(1H,s), 8.93(2H,brs). [0640]

Example 101

2-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N,N-dimethyl-isobutylamide trifluoroacetate [0641]
1H-NMR(DMSO-d6) δ: [0642]
1.41(9H,s), 1.56(6H,s), 3.56(3H,s), 3.65(3H,s), 5.54(2H,s), 6.04(2H,s), 7.25-7.68(9H,m), 7.99(2H,s), 9.05(2H,brs). [0643]

Example 102

2-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzenesulfonamide hydrobromide [0644]
1H-NMR(DMSO-d6) δ: [0645]
1.43(18H,s), 5.87(2H,s), 6.03(2H,s), 6.90(1H,d,J=7.8 Hz), 7.13-7.62(5H,m), 7.68(1H,d,J=7.9 Hz), 7.867(2H,s), 7.89(2H,s), 7.97-8.05(1H,m), 8.13(1H,s), 9.06(2H,brs). [0646]

Example 103

2-[3-(2-Butyl-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0647]
1H-NMR(DMSO-d6) δ: [0648]
0.97(3H,d,J=7.3 Hz), 1.40-1.50(20H,m), 1.57-1.69(2H,m), 2.76(2H,brt,J=8.0 Hz), 5.53(2H,s), 6.01(2H,s), 6.61(1H,d,J=7.8 Hz), 7.13(1H,t,J=7.8 Hz), 7.21-7.35(5H,m), 7.67(1H,d,J=7.8 Hz), 7.862(2H,s). [0649]

Example 104

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-(2,6-dimethoxy-benzylamino)-benzimidazol-1-yl]-ethanone hydrobromide [0650]
1H-NMR(DMSO-d6) δ: [0651]
1.38(18H,s), 4.55(2H,d,J=4.3 Hz), 5.82(2H,brs), 6.68(2H,d, J=7.5 Hz), 7.20-7.35(3H,m), 7.51(1H,t,J=7.5 Hz), 7.77(2H,s), 8.05(1H,s), 13.13(1H,brs). [0652]

Example 105

3-(4-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-2,2-dimethyl-propanoic acid hydrochloride [0653]
1H-NMR(DMSO-d6) δ: [0654]
1.03(6H,s), 1.431(18H,s), 2.75(2H,s), 5.48(2H,s), 5.97(2H,s), 7.168(4H,brs), 7.22-7.33(2H,m), 7.42-7.67(2H,m), 7.842(2H,s), 8.12(1H,s), 8.95(2H,brs). [0655]

Example 106

2-(2-Amino-benzimidazol-1-ylmethyl)-2,5,7,8-tetramethyl-chroman-6-ol hydrobromide [0656]
1H-NMR(DMSO-d6) δ: [0657]
1.16(3H,s), 1.60-1.70(1H,m), 1.87(3H,s), 1.97(3H,s), 2.00(3H,s), 1.87-2.08(1H,m), 2.48-2.63(2H,m), 4.33(1H,d,J=15 Hz), 4.45(1H,d,J=15 Hz), 7.18-7.25(2H,m), 7.32-7.38(1H,d,J=8.0 Hz), 7.46(1H,s), 7.50-7.60(1H,m), 8.65(2H,s), 12.70(1H,s). [0658]

Example 107

Ethyl 3-(2-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-propanoate hydrobromide [0659]
1H-NMR(DMSO-d6) δ: [0660]
1.29(3H,t,J=7.3 Hz), 1.438(18H,s), 2.74(2H,t,J=7.8 Hz), 3.03(2H,t,J=7.8 Hz), 4.11(2H,q,J=7.3 Hz), 5.57(2H,s), 6.02(2H,brs), 6.53(1H,d,J=7.6 Hz), 7.14(1H,t,J=7.6 Hz), 7.22-7.40(5H,m), 7.67(1H,d,J=7.6 Hz), 8.88(2H,brs). [0661]

Example 108

3-(2-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenyl)-propanoic acid hydrochloride [0662]
1H-NMR(DMSO-d6) δ: [0663]
1.423(18H,s), 2.68(2H,brt,J=7.6 Hz), 2.99(2H,brt,J=7.6 Hz), 5.60(2H,s), 6.01(2H,s), 6.51(1H,brd,J=7.7 Hz), 7.13(1H,brt,J=7.7 Hz), 7.19-7.39(5H,m), 7.63(1H,d,J=7.7 Hz), 7.83(2H,s). [0664]

Example 109

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2-hydroxymethyl-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrochloride [0665]
1H-NMR(DMSO-d6) δ: [0666]
1.43(18H,s), 4.72(2H,s), 5.56(2H,s), 6.06(2H,s), 6.64(1H,d,J=7.3 Hz), 7.12-7.34(4H,m), 7.37(1H,d,J=7.3 Hz), 7.50(1H,d,J=7.3 Hz), 7.65(1H,d,J=7.3 Hz), 7.86(2H,s), 8.12(1H,s), 9.07(2H,brs) [0667]

Example 110

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(2-propoxy-benzyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0668]
1H-NMR(DMSO-d6) δ: [0669]
0.98(3H,t,J=7.5 Hz), 1.433(18H,s), 1.68-1.83(2H,m), 3.99(2H,t,J=7.1 Hz), 5.42(2H,s), 5.97(2H,brs), 6.92(1H,t,J=7.6 Hz), 6.99-7.36(6H,m), 7.61(1H,d,J=7.6 Hz), 7.846(2H,s), 8.12(1H,s), 8.86(2H,s). [0670]

Example 111

1-(4-Amino-3,5-dimethyl-phenyl)-2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0671]
1H-NMR(DMSO-d6) δ: [0672]
2.15(6H,s), 5.53(2H,s), 5.83(2H,s), 7.20-7.54(9H,m), 7.58(2H,s), 9.03(2H,s). [0673]

Example 112

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl)-2,5,7,8-tetramethyl-chroman-6-ol hydrochloride [0674]
1H-NMR(DMSO-d6) δ: [0675]
1.20(3H,s), 1.62-1.76(1H,m), 1.84(3H,s), 1.98(3H,s), 2.01(3H,s), 2.03-2.10(1H,m), 2.50-2.66(2H,m), 4.48(1H,d,J=15 Hz), 4.61(1H,d,J=15 Hz), 5.55(2H,s), 7.15-7.35(6H,m), 7.41(1H,d,J=10 Hz), 7.49(1H,br), 7.61(1H,br), 9.38(2H,s). [0676]

Example 113

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-phenothiazin-10-yl-ethanone hydrobromide [0677]
1H-NMR(DMSO-d6) δ: [0678]
5.50(4H,s), 7.10-7.76(17H,m), 9.22(2H,s). [0679]

Example 114

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-phenoxazin-10-yl-ethanone hydrobromide [0680]
1H-NMR(DMSO-d6) δ: [0681]
5.40-5.53(4H,br), 7.20-7.38(15H,m), 7.43(1H,d,J=9.0 Hz), 7.85(1H,d,J=9.0 Hz), 9.13(1H,s), 9.15(1H,s). [0682]

Example 115

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(3-furan-3-ylmethyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0683]
1H-NMR(DMSO-d6) δ: [0684]
1.43(18H,s), 5.35(2H,s), 5.94(2H,s), 6.46(1H,s), 7.22-7.37(2H,m), 7.60(1H,d,J=7.9 Hz), 7.65-7.72(2H,m), 7.65-7.88(5H,m), 8.09(1H,brs), 8.96(2H,brs). [0685]

Example 116

2-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-benzonitrile hydrobromide [0686]
1H-NMR(DMSO-d6) δ: [0687]
1.43(18H,s), 5.78(2H,s), 6.03(2H,brs), 6.87(1H,d,J=7.2 Hz), 7.23-7.36(2H,m), 7.47-7.73(4H,m), 7.86(2H,s), 7.99(1H,d,J=7.2 Hz), 8.12(1H,brs), 8.99(2H,brs). [0688]

Example 117

N-{4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2,6-diisopropyl-phenyl}-methanesulfonamide hydrobromide [0689]
1H-NMR(DMSO-d6) δ: [0690]
1.22(12H,brs), 3.11(2H,s), 5.52(2H,s), 6.02(2H,brs), 7.15-7.71(9H,m), 7.85(2H,s), 9.02(2H,brs), 9.26(1H,s). [0691]

Example 118

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(4-ethyl-hexyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0692]
1H-NMR(DMSO-d6) δ: [0693]
0.777(6H,brt,J=7.2 Hz), 1.10-1.73(27H,m), 4.20(2H,brt,J=6.9 Hz), 5.91(2H,s), 7.26(1H,brt,J=7.4 Hz), 7.33(1H,brt,J=7.4 Hz), 7.58(1H,d,J=7.4 Hz), 7.64(1H,d,J=7.4 Hz), 7.82(2H,s), 8.09(1H,brs), 8.75(2H,brs). [0694]

Example 119

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2-ethyl-butyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0695]
1H-NMR(DMSO-d6) δ: [0696]
0.85(6H,t,J=6.8 Hz), 1.18-1.54(22H,m), 1.82-1.97(1H,m), 4.12(2H,brd,J=7.0 Hz), 5.93(2H,brs), 7.20-7.65(4H,m), 7.82(2H,s), 8.08(1H,brd), 8.71(2H,brs). [0697]

Example 120

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-oxo-5H-phenothiazin-10-yl)-ethanone hydrobromide [0698]
1H-NMR(DMSO-d6) δ: [0699]
5.20-5.70(4H,br), 7.06-8.20(17H,m), 9.23(2H,s). [0700]

Example 121

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-ethanone hydrochloride [0701]
1H-NMR(DMSO-d6) δ: [0702]
1.48(3H,s), 1.75-1.88(1H,m), 2.00(3H,s), 2.10(3H,s), 2.21(3H,s), 2.21-2.33(1H,m), 2.33-2.67(2H,m), 5.33(1H,d,J=18 Hz), 5.52(2H,s), 5.82(1H,d,J=18 Hz), 7.00-7.47(9H,m), 9.30(2H,s). [0703]

Example 122

Ethyl 2-(2-{3-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenoxy)-propanoate hydrobromide [0704]
1H-NMR(DMSO-d6) δ: [0705]
1.086(3H,t,J=6.9 Hz), 1.429(18H,s), 1.54(3H,d,J=6.4 Hz), 3.97-4.17(2H,m), 5.11(1H,q,J=6.4 Hz), 5.44(1H,d,J=16.5 Hz), 5.52(1H,d,J=16.5 Hz), 5.90-6.05(2H,m), 6.88-7.00(2H,m), 7.13(1H,d,J=6.9 Hz), 7.16-7.63(5H,m), 7.842(2H,s), 8.11(1H,brs), 8.94 (2H,brs). [0706]

Example 123

2-(2-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl}-phenoxy)-propanoic acid hydrochloride [0707]
1H-NMR(DMSO-d6) δ: [0708]
1.42(18H,s), 1.54(3H,d,J=6.7 Hz), 5.02(1H,q,J=6.7 Hz), 5.44(1H,d,J=16.9 Hz), 5.52(1H,d,J=16.9 Hz), 5.97(2H,brs), 6.86-7.32(6H,m), 7.37(1H,d,J=7.8 Hz), 7.60(1H,d,J=7.8 Hz), 7.841(2H,s), 8.12(1H,s), 8.93(2H,brs). [0709]

Example 124

1-{3-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-benzimidazol-1-yl}-3-ethyl-pentan-2-one hydrobromide [0710]
1H-NMR(DMSO-d6) δ: [0711]
0.846(6H,t,J=7.9 Hz), 1.423(18H,s), 1.47-1.77(4H,m), 2.58-2.69(1H,m), 5.43(2H,s), 5.95(2H,s), 7.24-7.64(4H,m), 7.83(2H,s). [0712]

Example 125

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5,5-dioxo-5H-phenothiazin-10-yl)-ethanone hydrobromide [0713]
1H-NMR(DMSO-d6) δ: [0714]
5.51(4H,s), 7.15-7.48(9H,m), 7.70(2H,t,J=8.8 Hz), 7.85(2H,t,J=8.8 Hz), 8.00-8.18(4H,m), 9.20(1H,s), 9.22(1H,s). [0715]

Example 126

3-Benzyl-2-imino-2,3-dihydro-benzimidazole-1-carboxylic acid (3,5-di-tert-butyl-4-hydroxy-phenyl)-amide [0716]
1H-NMR(DMSO-d6) δ: [0717]
1.34(18H,s), 5.27(2H,s), 6.49(1H,s), 6.60(1H,s), 6.97-7.50(9H,m), 8.08(1H,s), 8.67-8.73(1H,m). [0718]

Example 127

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(2-isobutoxy-benzyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0719]
1H-NMR(DMSO-d6) δ: [0720]
1.01(6H,d,J=6.8 Hz), 1.429(18H,s), 2.00-2.14(1H,m), 3.83(2H,d,J=6.1 Hz), 5.42(2H,s), 5.97(2H,s), 6.87-6.94(2H,m), 7.07(1H,d,J=8.0 Hz), 7.17-7.35(4H,m), 7.61(1H,d,J=7.3 Hz), 7.844(2H,s), 8.11(1H,s), 8.88(2H,brs). [0721]

Example 128

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[3-(2-ethoxymethyl-benzyl)-2-imino-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0722]
1H-NMR(DMSO-d6) δ: [0723]
1.22(3H,t,J=7.1 Hz), 1.43(18H,s), 3.61(2H,q,J=7.1 Hz), 4.68(2H,s), 5.50(2H,s), 5.99(2H,s), 6.72(1H,d,J=7.1 Hz), 7.13-7.37(5H,m), 7.47(1H,d,J=6.6 Hz), 7.66 Hz(1H,d,J=7.7 Hz), 7.857(2H,s), 8.12(1H,brs), 8.91(2H,brs). [0724]

Example 129

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-ethanone hydrobromide [0725]
1H-NMR(DMSO-d6) δ: [0726]
1.38(6H,s), 4.39(2H,s), 5.53(2H,s), 5.94(2H,s), 7.00(1H,d,J=8.0 Hz), 7.24-7.42(8H,m), 7.44-7.50(1H,m), 7.58-7.64(1H,m), 7.91(1H,s), 8.99(2H,brs). [0727]

Example 130

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-ethanone hydrobromide [0728]
1H-NMR(DMSO-d6) δ: [0729]
1.36(6H,s), 1.38(9H,s), 4.39(2H,s), 5.52(2H,s), 5.86(2H,s), 7.22-7.50(9H,m), 7.78(1H,s), 7.84(1H,s). [0730]

Example 131

N-{4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-bromo-phenyl}-2,2-dimethyl-propionamide hydrobromide [0731]
1H-NMR(DMSO-d6) δ: [0732]
1.26(9H,brs), 5.54(2H,s), 6.02(2H,s), 7.19-8.09(11H,m), 8.34(1H,s), 9.06(2H,s), 9.15(1H,s). [0733]

Example 132

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-4-hydroxy-5-methanesulfonyl-phenyl)-ethanone hydrobromide [0734]
1H-NMR(DMSO-d6) δ: [0735]
1.42(9H,s), 3.43(3H,s), 5.52(2H,s), 6.01(2H,s), 7.20-7.45(7H,m), 7.49(1H,dd,J=5.6, 3.7 Hz), 7.62(1H,dd,J=5.6, 3.3 Hz), 8.07(1H,brs), 8.36(1H,s), 8.97(2H,s). [0736]

Example 133

2-(3-Benzyl-2-imino-4-propoxy-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0737]
1H-NMR(DMSO-d6) δ: [0738]
0.78(3H,t,J=7.2 Hz), 1.42(18H,s), 1.47-1.63(2H,m), 3.87-4.05(2H,m), 5.62(2H,s), 5.94(2H,s), 6.92(1H,d,J=8.0 Hz), 7.08-7.44(8H,m), 7.83(2H,s), 8.08(1H,brs), 8.78(2H,brs). [0739]

Example 134

2-(3-Benzyl-2-imino-5-propoxy-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0740]
1H-NMR(DMSO-d6) δ: [0741]
0.92(3H,t,J=7.6 Hz), 1.42(18H,s), 1.59-1.72(2H,m), 3.88(2H,t,J=7.2 Hz), 5.50(2H,s), 5.92(2H,s), 6.85(1H,d,J=8.8 Hz), 7.14(1H,s), 7.20-7.43(5H,m), 7.51(1H,d,J=8.8 Hz), 7.82(2H,s), 8.08(1H,brs), 8.82(2H,brs). [0742]

Example 135

tert-Butyl 5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-benzoate hydrobromide [0743]
1H-NMR(DMSO-d6) δ: [0744]
1.43(9H,s), 1.62(9H,s), 5.54(2H,s), 6.04(2H,s), 7.20-7.68(9H,m), 8.08(1H,brs), 8.37(1H,brs), 8.99(2H,brs), 12.38(1H,brs). [0745]

Example 136

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-benzoic acid trifluoroacetate [0746]
1H-NMR(DMSO-d6) δ: [0747]
1.40(9H,s), 5.52(2H,s), 5.99(2H,s), 7.21-7.68(9H,m), 7.98(1H,brs), 8.48(1H,brs), 8.96(2H,brs). [0748]

Example 137

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-3,5-diisopropoxy-phenyl)-ethanone hydrobromide [0749]
1H-NMR(DMSO-d6) δ: [0750]
1.29(12H,d,J=6.0 Hz), 4.55-4.68(2H,m), 5.52(2H,s), 5.91(2H,s), 7.20-7.40(9H,m), 7.47-7.49(1H,m), 7.58-7.61(1H,m), 8.98(1H,s), 8.99(1H,s). [0751]

Example 138

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-tert-butyl-2-hydroxy-phenyl)-ethanone hydrobromide [0752]
1H-NMR(DMSO-d6) δ: [0753]
1.25(9H.s), 5.52(2H.s), 5.78(2H.s), 7.04(1H.d.J=8.0 Hz), 7.25-7.35(5H.m), 7.40(2H.m), 7.48(1H.dd.J=4.0.8.0 Hz), 7.60(1H.dd.J=4.0.8.0 Hz), 7.64(1H.dd.J=2.0.8.0 Hz), 7.80(1H.d.J=2.0 Hz), 8.97(1H.brs), 11.01(1.brs). [0754]

Example 139

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-ethanone hydrobromide [0755]
1H-NMR(DMSO-d6) δ: [0756]
1.25(9H.s), 5.32(2H.s), 5.57(2H.s), 6.97(1H.d.J=8.0 Hz), 7.07(2H.m), 7.20(1H.m), 7.25-7.35(5H.m), 7.59(1H.d.J=8.0 Hz), 7.72(1H.brs). [0757]

Example 140

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-5-dimethylamino-4-hydroxy-phenyl)-ethanone hydrobromide [0758]
1H-NMR(DMSO-d6) δ: [0759]
1.40(9H,s), 2.63(6H,s), 5.53(2H,s), 5.95(2H,s), 7.20-7.45(8H,m), 7.49(1H,dd,J=5.6, 3.4 Hz), 7.62(1H,dd,J=5.6, 3.0 Hz), 7.72(1H,s), 7.77(1H,s), 8.95(2H,brs). [0760]

Example 141

3-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-chromen-2-one hydrobromide [0761]
1H-NMR(DMSO-d6) δ: [0762]
5.52(2H.s), 5.80(2H.s), 6.76(2H.dd.J=2.0.8.0 Hz), 7.09(2H.dd.J=4.0.8.0 Hz), 7.24-7.60(9H.m), 8.90(1H.s). [0763]

Example 142

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2,5-dihydroxy-phenyl)-ethanone hydrobromide [0764]
1H-NMR-(DMSO-d6) δ: [0765]
5.52(2H,s), 5.75(2H,s), 6.94(1H,d,J=8.0 Hz), 7.02(1H,dd,J=2.0, 8.0 Hz), 7.20(1H,d,J=2.0 Hz), 7.25-7.35(5H,m), 7.38(2H,m), 7.48(1H,m), 7.59(1H,m), 8.88(1H,s), 9.22(1H,s), 10.55(1H,s) [0766]

Example 143

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-nitro-benzofuran-2-yl)-ethanone hydrobromide [0767]
1H-NMR(DMSO-d6) δ: [0768]
5.52(2H,s), 5.96(2H,s), 7.29-7.36(5H,m), 7.40(2H,m), 7.53(1H,dd,J=4.0, 8.0 Hz), 7.72(1H,dd,J=4.0.8.0z), 8.20(1,d,J=8.0 Hz), 8.24(1H,s), 8.46(1,dd,J=2.0, 8.0 Hz), 9.10(1,brs). [0769]

Example 144

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-4-hydroxy-5-(1-hydroxy-ethyl)-phenyl]-ethanone trifluoroacetate [0770]
1H-NMR(DMSO-d6) δ: [0771]
1.41(9H,s), 1.44(3H,d,J=6.8 Hz), 5.14(1H,q,J=6.4 Hz), 5.52(2H,s), 5.95(2H,s), 7.22-7.40(7H,m), 7.42-7.51(1H,m), 7.58-7.63(1H,m), 7.76(1H,s), 7.79(1H,s), 8.98(2H,brs), 10.41(1H,brs). [0772]

Example 145

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-tert-butyl-2,3-dihydro-benzofuran-5-yl)-ethanone hydrobromide [0773]
1H-NMR(DMSO-d6) δ: [0774]
1.34(9H,m), 3.25(2H,t,J=6.0 Hz), 4.71(2H,t,J=6.0 Hz), 5.52(2H,s), 5.92(2H,s), 7.25-7.35(5H,m), 7.40(2H,m), 7.49(1H,m), 7.60(1H,m), 7.75(1H,s), 7.89(1H,s). [0775]

Example 146

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-bromo-1-(2,2-dimethyl-propyl)-1H-indol-5-yl]-ethanone hydrobromide [0776]
1H-NMR(DMSO-d6) δ: [0777]
1.92(9H,2), 4.10(2H,s), 5.53(2H,s), 6.12(2H.s), 7.25-7.35(5H,m), 7.40(2H,m), 7.51(1H,dd,J=4.0, 8.0 Hz), 7.65(1H,dd,J=4.0,8.0z), 7.76(1H,s), 7.84(1,d,J=8.0 Hz), 7.90(1H,d,J=8.0 Hz), 8.26(1H,d,J=2.0 Hz), 8.98(1,brs). [0778]

Example 147

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-methanesulfonamide hydrochloride [0779]
1H-NMR(DMSO-d6) δ: [0780]
1.414(9H,s), 3.03(3H,s), 5.55(2H,s), 5.97(2H,s), 7.20-7.88(12H,m), 9.06(2H,brs). [0781]

Example 148

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-tert-butyl-2-methyl-benzoxazol-5-yl)-ethanone hydrobromide [0782]
1H-NMR(DMSO-d6) δ: [0783]
1.47(9H,s), 2.72(3H,s), 5.54(2H,s), 6.09(2H,s), 7.23-7.70(9H,m), 7.87(1H,s), 8.38(1H,s), 9.02(2H,brs). [0784]

Example 149

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-bromo-1,2,3,3-tetramethyl-2,3-dihydro-1H-indol-5-yl)-ethanone hydrobromide [0785]
1H-NMR(DMSO-d6) δ: [0786]
1.05(3H,s), 1.15(3H,d,J=6.0 Hz), 1.28(3H,s), 3.20(3H,s), 5.55(2H,s), 5.84(2H.s), 7.25-7.35(5H,m), 7.38(2H,m), 7.47(1H,dd,J=4.0, 8.0 Hz), 7.56(1H,dd,J=4.0, 8.0 Hz), 7.60(1H,s), 7.96(1H,s). [0787]

Example 150

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N-methyl-methanesulfonamide hydrobromide [0788]
1H-NMR(DMSO-d6) δ: [0789]
1.39(9H,s), 3.16(6H,s), 5.55(2H,s), 5.97(2H,broad), 7.20-7.69(9H,m), 7.88(1H,s), 8.05(1H,s), 9.07(2H,brs). [0790]

Example 151

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-[2-imino-3-(4-nitro-benzyl)-2,3-dihydro-benzimidazol-1-yl]-ethanone hydrobromide [0791]
1H-NMR(DMSO-d6) δ: [0792]
1.42(18H,s), 5.68(2H,s), 5.98(2H,s), 7.20-7.52(7H,m), 7.83(2H,s), 8.27(2H,d,J=8.0 Hz). [0793]

Example 152

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-4-hydroxy-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-ethanone trifluoroacetate [0794]
1H-NMR(DMSO-d6) δ: [0795]
1.41(9H,s), 1.61(6H,s), 5.54(2H,s), 5.97(2H,s), 7.23-7.42(7H,m), 7.44-7.50(1H,m), 7.57-7.64(1H,m), 7.72(1H,s), 7.80(1H,s), 9.00(2H,brs), 11.70(1H,brs). [0796]

Example 153

1-Adamantan-1-yl-2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0797]
1H-NMR(DMSO-d6) δ: [0798]
1.73(6H,brs), 1.94(6H,brs), 5.47(2H,s), 5.51(2H,s), 7.25-7.35(5H,m), 7.38(2H,m), 7.40-7.46(2H,m). [0799]

Example 154

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-7-tert-butyl-3-methyl-3H-benzoxazol-2-one hydrobromide [0800]
1H-NMR(DMSO-d6) δ: [0801]
1.43(9H,s), 3.42(3H,s), 5.55(2H,s), 6.06(2H,s), 7.21-7.69(9H,m), 7.78(1H,s), 7.88(1H,s), 9.04(2H,brs). [0802]

Example 155

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-ethyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-ethanone hydrobromide [0803]
1H-NMR(DMSO-d6) δ: [0804]
1.20(3H,t,J=6.8 Hz), 1.37(6H,s), 2.63(2H,q,J=6.8 Hz), 4.38(2H,s), 5.50(2H,s), 5.91(2H,s), 7.20-7.45(9H,m), 7.80(2H,s). [0805]

Example 156

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethanone hydrobromide [0806]
1H-NMR(DMSO-d6) δ: [0807]
4.32-4.40(4H,m), 5.54(2H,s), 5.93(2H,s), 7.08(1H,d,J=8.0 Hz), 7.14-7.42(7H,m), 7.45-7.52(1H,m), 7.57-7.62(3H,m), 8.99(1H,brs). [0808]

Example 157

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2,2-dimethyl-benzo[1,3]dioxol-5-yl)-ethanone hydrobromide [0809]
1H-NMR(DMSO-d6) δ: [0810]
1.68(6H,s), 5.52(2H,s), 5.90(2H,s), 7.08-7.11(1H,m), 7.23-7.51(8H,m), 7.57-7.72(3H,m), 8.99(2H,brs). [0811]

Example 158

N-{4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2,6-diisopropyl-phenyl}-N-methyl-methanesulfonamide hydrobromide [0812]
1H-NMR(DMSO-d6) δ: [0813]
1.26(12H,brd), 3.12(3H,s), 3.22(1H,s), 3.24-3.35(2H,m), 5.54(2H,s), 6.06(2H,brs), 7.25-7.73(9H,m), 7.91(2H,s), 9.01(2H,brs). [0814]

Example 159

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-ethanone hydrobromide [0815]
1H-NMR(DMSO-d6) δ: [0816]
1.53(6H,m), 4.96(2H,s), 5.52(2H,s), 5.91(2H,s), 7.22-7.52(9H,m), 7.57-7.62(1H,m), 7.87-7.98(2H,m). [0817]

Example 160

N-{4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-tert-butyl-phenyl}-acetamide hydrobromide [0818]
1H-NMR(DMSO-d6) δ: [0819]
1.38(9H,s), 2.06(3H,s), 5.55(2H,s), 6.00(2H,s), 7.21-7.70(10H,m), 7.96(1H,d,J=8.0 Hz), 8.04(1H,s), 9.00(2H,brs), 9.40(1H,s). [0820]

Example 161

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-tert-butyl-2,2-dimethyl-benzo[1,3]dioxol-5-yl)-ethanone hydrobromide [0821]
1H-NMR(DMSO-d6) δ: [0822]
1.37(9H,s), 1.72(6H,s), 5.51(2H,s), 5.92(2H,s), 7.24-7.46(9H,m), 7.53-7.62(2H,m). [0823]

Example 162

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid dimethylamide hydrobromide [0824]
1H-NMR(DMSO-d6) 6: [0825]
2.23(3H,s), 2.55(3H,s), 2.95(6H,s), 5.58(2H,s), 5.61(2H,s), 7.10-7.70(9H,m). [0826]

Example 163

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-methoxy-phenyl)-ethanone hydrobromide [0827]
1H-NMR(DMSO-d6) δ: [0828]
1.46(18H,s), 3.72(3H,s), 5.56(2H,s), 6.04(2H,s), 7.28-7.43(7H,m), 7.52(1H,dd,J=2.8 Hz,6.0 Hz), 7.68(1H,dd,2,8 Hz,6.8 Hz), 7.98(2H,s), 9.00(1H,s). [0829]

Example 164

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2,6-di-tert-butyl-phenyl phenylcarbamate hydrobromide [0830]
1H-NMR(DMSO-d6) δ: [0831]
1.43(18H,s), 5.56(2H,s), 6.09(2H,s), 7.07(1H,t,J=7.2 Hz), 7.25-7.45(9H,m), 7.52(3H,d,J=7.2 Hz), 7.71(1H,dd,J=2.8 Hz,6.4 Hz), 8.04(2H,s), 9.04(2H,s), 10.48(1H,s). [0832]

Example 165

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4,6-di-tert-butyl-5-hydroxy-pyrimidin-2-yl)-ethanone hydrobromide [0833]
1H-NMR(DMSO-d6) δ: [0834]
1.46(18H,s), 5.55(2H,s), 5.93(2H,s), 7.15-7.73(9H,m), 8.98(2H,brs). [0835]

Example 166

4-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2,6-di-tert-butyl-phenyl methylcarbamate hydrobromide [0836]
1H-NMR(DMSO-d6) δ: [0837]
1.38(18H,s),2.69(3H,d,J=4.4 Hz),5.57(2H,s),6.08(2H,s),7. 25-7.45(5H,s),7.52(1H,dd,J=3.2 Hz,5.6 Hz),7.70(1H,dd,J=2.0 Hz,6.0 Hz),7. 95(1H,q,J=4.4 Hz),7.99(2H,s),9.05(2H,s). [0838]

Example 167

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-3,3,5,5-tetramethyl-piperidin-1-yl)-ethanone hydrobromide [0839]
1H-NMR(DMSO-d6) δ: [0840]
0.74(3H,s), 0.87(3H,s), 0.96(3H,s), 1.02(3H,s), 2.43(1H,d,J=12.8 Hz), 2.94(1H,d,J=14.0 Hz), 3.31(1H,d,J=5.6 Hz), 3.61(1H,d,J=13.6 Hz), 3.98(1H,d,J=14.8 Hz), 4.83(1H,brs), 5.16(2H,dd,J=18.0 Hz,17.6 Hz), 5.45(1H,s), 7.18-7.42(9H,m). [0841]

Example 168

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N-methyl-acetamide hydrochloride [0842]
1H-NMR(DMSO-d6) δ: [0843]
1.37(9H,s), 1.72(3H,s), 3.02(3H,s), 5.50(2H,s), 5.82(2H,brs), 7.10-7.90(10H,m). [0844]

Example 169

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,4-bis-tert-butoxymethyl-pyrrolidin-1-yl)-ethanone hydrobromide [0845]
1H-NMR(DMSO-d6) δ: [0846]
1.12(9H,s), 1.17(9H,s), 2.28-2.36(2H,m), 2.45-2.56(2H,m), 3.20-3.78(6H,m), 5.05(2H,s), 5.42(2H,s), 7.14-7.42(9H,m). [0847]

Example 170

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-tert-butyl-2,2-dimethyl-2,3-dihydro-benzofuran-5-yl)-ethanone hydrobromide [0848]
1H-NMR(DMSO-d6) δ: [0849]
1.36(9H,s), 1.48(6H,s), 3.08(2H,s), 5.51(2H,s), 6.93(2H,s), 7.25-7.52(8H,m), 7.57-7.62(1H,m), 7.75(1H,s), 7.86(1H,s). [0850]

Example 171

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl}-N-methyl-methanesulfonamide hydrobromide [0851]
1H-NMR(DMSO-d6) δ: [0852]
1.39(6H,s), 3.07(3H,s), 3.23(3H,s), 4.48(2H,s), 5.54(2H,s), 5.98(2H,s), 7.27-7.42(7H,m), 7.48-7.53(1H,m), 7.60-7.66(1H,m), 7.90(1H,s), 7.95(1H,s), 9.03(2H,brs). [0853]

Example 172

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-4,4-dimethyl-thiochroman-6-yl)-ethanone hydrochloride [0854]
1H-NMR(DMSO-d6) δ: [0855]
1.37(6H,s), 1.51(9H,s), 1.87-1.95(2H,m), 3.06-3.12(2H,m), 5.46(1H,s), 5.94(2H,s), 7.14-7.54(9H,m), 7.77-7.84(1H,m), 7.96-8.03(1H,m). [0856]

Example 173

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-tert-butyl-3,3-dimethyl-2,3-dihydro-benzo[b]thiophen-5-yl)-ethanone hydrobromide [0857]
1H-NMR(DMSO-d6) δ: [0858]
1.39(s,6H), 1.45(s,9H), 3.28(s,2H), 5.53(s,2H), 5.98(s,2H), 7.24-7.50(m,8H), 7.57-7.64(m,1H), 7.69-7.72(m,1H), 7.83-7.86(m,1H). [0859]

Example 174

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-4-(2,2-dimethyl-propoxy)-phenyl]-ethanone hydrobromide [0860]
1H-NMR(DMSO-d6) 6: [0861]
1.12(s,9H), 1.44(s,9H), 3.85(s,2H), 5.54(s,2H), 5.97(s,2H), 7.22-7.44(m,8H), 7.46-7.52(m,1H), 7.57-7.63(m,1H), 7.91-7.94(m,1H), 7.99-8.04(m,1H). [0862]

Example 175

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-4,4-dimethyl-chroman-6-yl)-ethanone hydrobromide [0863]
1H-NMR(DMSO-d6) δ: [0864]
1.38(15H,s), 1.84-1.91(2H,m), 4.29-4.37(2H,m), 5.55(2H,s), 6.00(2H,s), 7.27-7.38(5H,m), 7.39-7.45(2H,m), 7.48-7.53(1H,m), 7.61-7.66(1H,m), 7.73-7.77(1H,m), 7.99-8.02(1H,m), 8.99(2H,brs). [0865]

Example 176

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl}-N-methyl-acetamide hydrobromide [0866]
1H-NMR(DMSO-d6) δ: [0867]
1.39(6H,s), 1.82(3H,s), 3.14(3H,s), 4.48(2H,s), 5.53(2H,s), 5.95(2H,s), 7.27-7.43(7H,m), 7.48-7.52(1H,m), 7.60-7.66(1H,m), 7.95(1H,s), 7.98(1H,s). [0868]

Example 177

1-{3-(1-Acetoxy-1-methyl-ethyl)-5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-hydroxy-phenyl}-1-methyl-ethyl acetate hydrobromide [0869]
1H-NMR(DMSO-d6) δ: [0870]
1.86(12H,s), 2.05(6H,s), 3.82(3H,s), 5.65(2H,s), 6.34(2H,s), 7.03-7.31(9H,m), 8.07(2H,s), 9.56(9H,brs). [0871]

Example 178

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-bromo-5-tert-butyl-4-hydroxy-phenyl)-ethanone hydrobromide [0872]
1H-NMR(DMSO-d6) δ: [0873]
1.41(9H,s), 5.56(2H,s), 5.98(2H,s), 7.25-7.45(7H,m), 7.48-7.54(1H,m), 7.62-7.68(1H,m), 7.83-7.88(1H,m), 8.20-8.23(1H,m), 9.02(2H,brs). [0874]

Example 179

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-4,4-dimethyl-1-oxo-thiochroman-6-yl)-ethanone hydrobromide [0875]
1H-NMR(DMSO-d6) 6: [0876]
1.39(3H,s), 1.56(3H,s), 1.62(9H,s), 1.73-1.80(1H,m), 2.81-2.91(1H,m), 3.09-3.27(2H,m), 5.56(2H,s), 6.01-6.20(2H,m), 7.26-7.46(7H,m), 7.48-7.54(1H,m), 7.64-7.71(1H,m), 7.90-7.95(1H,m), 8.19-8.24(1H,m), 9.04(2H,brs). [0877]

Example 180

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-4,4-dimethyl-1,1-dioxo-thiochroman-6-yl)-ethanone hydrobromide [0878]
1H-NMR(DMSO-d6) 6: [0879]
1.50(6H,s), 1.63(9H,s), 2.29-2.35(2H,m), 3.54-3.59(2H,m), 5.55(2H,s), 6.08(2H,s), 7.26-7.45(7H,m), 7.48-7.53(1H,m), 7.64-7.70(1H,m), 8.13-8.19(2H,m), 9.02(2H,brs). [0880]

Example 181

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3,5-bis-(1-hydroxy-1-methyl-ethyl)-4-methoxy-phenyl]-ethanone hydrochloride [0881]
1H-NMR(DMSO-d6) δ: [0882]
1.65(12H,s), 3.96(3H,s), 5.62(2H,s), 6.23(2H,s), 7.09-7.28(9H,m), 8.25(2H,s), 9.26(2H,brs). [0883]

Example 182

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-5-chloro-4-hydroxy-phenyl)-ethanone hydrobromide [0884]
1H-NMR(DMSO-d6) δ: [0885]
1.42(9H,s), 5.42(1H,s), 5.56(2H,s), 5.98(2H,s), 7.26-7.44(7H,m), 7.48-7.54(1H,m), 7.61-7.67(1H,m), 7.82-7.86(1H,m), 8.07-8.10(1H,m), 9.04(2H,brs). [0886]

Example 183

2-(1-Benzyl-1H-benzimidazol-2-ylamino)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propan-1-one hydrochloride [0887]
1H-NMR(DMSO-d6) δ: [0888]
1.41(18H,s), 1.61(3H,d,J=8 Hz), 5.48-5.71(2H,m), 5.77-5.86(1H,m), 7.20-7.47(9H,m), 7.81-7.87(2H,m), 8.01-8.07(1H,m). [0889]

Example 184

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-7-tert-butyl-1,3-dihydro-indol-2-one hydrobromide [0890]
1H-NMR(DMSO-d6) δ: [0891]
1.36(9H,s), 3.63(2H,s), 5.52(2H,s), 5.95(2H,s), 7.20-7.62(9H,m), 7.84(2H,s), 8.96(1H,s), 10.68(1H,s). [0892]

Example 185

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-7-tert-butyl-3,3-dimethyl-1,3-dihydro-indol-2-one hydrobromide [0893]
1H-NMR(DMSO-d6) δ: [0894]
1.33(6H,s), 1.37(9H,s), 5.54(2H,s), 6.00(2H,s), 7.24-7.43(7H,m), 7.46-7.52(1H,m), 7.61-7.66(1H,m), 7.86(1H,d,J=2.4 Hz), 7.95(1H,d,J=2.4 Hz), 9.00(1H,s), 10.64(1H,s). [0895]

Example 186

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[7-(1-methoxy-1-methyl-ethyl)-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl]-ethanone hydrobromide [0896]
1H-NMR(DMSO-d6) δ: [0897]
1.34(6H,s), 1.53(6H,s), 3.17(3H,s), 4.39(2H,s), 5.51(2H,s), 5.94(2H,s), 7.24-7.48(8H,m), 7.58-7.64(1H,m), 7.89(1H,s), 7.92(1H,s). [0898]

Example 187

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-chroman-6-yl)-ethanone hydrobromide [0899]
1H-NMR(DMSO-d6) δ: [0900]
1.38(9H,s), 1.96-2,01(2H,m), 2.84-2.92(2H,m), 4.29-4.35(2H,m), 5.53(2H,s), 5.94(2H,s), 7.28-7.43(7H,m), 7.47-7.51(1H,m), 7.57-7.62(1H,m), 7.71(1H,s), 7.77(1H,s), 8.98(2H,brs). [0901]

Example 188

4-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-ylmethyl)-2,6-di-tert-butyl-phenol hydrobromide [0902]
1H-NMR(DMSO-d6) δ: [0903]
1.30(18H,s), 5.39(2H,s), 5.53(2H,s), 7.08(2H,s), 7.09(1H,s), 7.25-7.40(7H,m), 7.52(1H,d,J=7.6 Hz), 7.63(1H,d,J=7.2 Hz), 9.15(2H,s). [0904]

Example 189

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-ethanone O-methyl-oxime hydrobromide [0905]
1H-NMR(DMSO-d6) δ: [0906]
1.51(18H,s), 4.03(3H,s), 5.32(2H,s), 5.55(2H,s), 6.76(2H,d,J=6.8 Hz), 6.95(2H,s), 7.20-7.40(8H,m), 7.55(1H,d,J=7.6 Hz), 9.09(2H,s). [0907]

Example 190

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N-ethyl-methanesulfonamide hydrobromide [0908]
1H-NMR(DMSO-d6) δ: [0909]
1.02(3H,t,J=6.8 Hz), 1.41(9H,s), 2.47-2.54(2H,m), 3.17(3H,s), 5.56(2H,s), 5.92(2H,s), 7.24-7.52(8H,m), 7.63-7.68(1H,m), 7.88(1H,s), 7.98(1H,s). [0910]

Example 191

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N-(2-methoxy-ethyl)-methanesulfonamide hydrobromide [0911]
1H-NMR(DMSO-d6) δ: [0912]
1.40(9H,s), 3.19(3H,s), 3.23(3H,s), 3.62-3.88(4H,m), 5.54(2H,s), 5.96(2H,s), 7.26-7.52(8H,m), 7.64-7.69(1H,m), 7.91(1H,s), 7.99(1H,s)., 8.98(2H,brs). [0913]

Example 192

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N-(2-hydroxy-ethyl)-methanesulfonamide hydrobromide [0914]
1H-NMR(DMSO-d6) δ: [0915]
1.39(9H,s), 3.19(3H,s), 5.57(2H,s), 5.98(2H,s), 7.24-7.52(8H,m), 7.60-7.66(1H,m), 7.88(1H,s), 8.02(1H,s). [0916]

Example 193

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-5-ethyl-4-hydroxy-phenyl)-ethanone hydrobromide [0917]
1H-NMR(DMSO-d6) δ: [0918]
1.18(3H,t,J=7.6 Hz), 1.41(9H,s), 2.71(2H,q,J=7.6 Hz), 5.53(2H,s), 5.95(2H,s), 7.24-7.35(5H,m), 7.37-7.43(2H,m), 7.46-7.51(1H,m), 7.58-7.63(1H,m), 7.77(2H,s). [0919]

Example 194

1-(1-Acetyl-7-tert-butyl-3,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [0920]
1H-NMR(DMSO-d6) δ: [0921]
1.24(6H,s), 1.37(9H,s), 2.24(3H,s), 3.83(2H,s), 5.54(2H,s), 6.01(2H,s), 7.24-7.36(5H,m), 7.37-7.43(2H,m), 7.45-7.52(1H,m), 7.62-7.68(1H,m), 7.74(1H,d,J=1.6 Hz), 8.02(1H,d,J=1.6 Hz), 9.03(1H,s). [0922]

Example 195

Butane-1-sulfonic acid {5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-amide hydrobromide [0923]
1H-NMR(DMSO-d6) δ: [0924]
0.77(3H,t,J=6.8 Hz), 1.17-1.32(2H,m), 1.50-1.62(2H,m), 2.83(2H,t,J=6.8 Hz), 5.42(2H,s), 5.64(2H,s), 7.12(2H,m), 7.26-7.58(7H,m), 7.45(1H,s), 7.60(1H,s). [0925]

Example 196

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-5-(2-ethoxy-ethyl)-4-hydroxy-phenyl]-ethanone hydrobromide [0926]
1H-NMR(DMSO-d6) 6: [0927]
1.11(3H,t,J=6.8 Hz), 1.40(9H,s), 2.92-2.98(2H,m), 3.58-3.64(m,2H), 5.49(2H,s), 5.88(2H,s), 7.25-7.46(7H,m), 7.52-7.58(1H,m), 7.74(3H,m). [0928]

Example 197

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-4-hydroxy-5-(2-methoxyethyl)-phenyl]-ethanone hydrobromide [0929]
1H-NMR(DMSO-d6) δ: [0930]
1.41(9H,s), 2.96(2H,t,J=6.4 Hz), 3.28(3H,s), 3.57(2H,t,J=6.4 Hz), 5.53(2H,s), 5.94(2H,s), 7.24-7.35(5H,m), 7.37-7.42(2H,m), 7.46-7.50(1H,m), 7.58-7.62(1H,m), 7.79(2H,s). [0931]

Example 198

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-hydroxy-phenyl}-N-methyl-methanesulfonamide hydrochloride [0932]
1H-NMR(DMSO-d6) δ: [0933]
3.08(3H,s), 3.21(3H,s), 5.66(2H,s), 6.09(2H,s), 7.23-7.43(8H,m), 7.47-7.53(1H,m), 7.57-7.63(1H,m), 7.93-7.98(1H,m), 9.52(2H,brs), 11.68(1H,s). [0934]

Example 199

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-4-hydroxy-5-methyl-phenyl)-ethanone hydrobromide [0935]
1H-NMR(DMSO-d6) δ: [0936]
1.40(9H,s), 2.30(3H,s), 5.54(2H,s), 5.93(2H,s), 7.23-7.50(8H,m), 7.56-7.62(1H,m), 7.72-7.82(2H,m). [0937]

Example 200

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-4-hydroxy-5-methoxymethyl-phenyl)-ethanone hydrobromide [0938]
1H-NMR(DMSO-d6) δ: [0939]
1.41(9H,s), 4.57(2H,s), 5.55(2H,s), 5.97(2H,s), 7.22-7.43(7H,m), 7.45-7.52(1H,m), 7.58-7.64(1H,m), 7.86(1H,s), 7.89(1H,s), 9.03(2H,s). [0940]

Example 201

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-ethyl-2-hydroxy-phenyl}-N-methyl-methanesulfonamide hydrobromide [0941]
1H-NMR(DMSO-d6) δ: [0942]
1.22(3H,t,J=6.8 Hz), 2.72(2H,q,J=6.8 Hz), 3.01(3H,s), 3.34(3H,s), 5.60(2H,s), 6.24(2H,s), 7.08-7.37(9H,m), 7.82(1H,s), 8.24(1H,s), 9.12(2H,brs). [0943]

Example 202

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-2-hydroxy-3-isopropyl-phenyl}-N-methyl-methanesulfonamide hydrobromide [0944]
1H-NMR(DMSO-d6) δ: [0945]
1.08(6H,d,J=7.2 Hz), 2.98(3H,s), 3.27(3H,s), 3.25-3.34(1H,m), 5.57(2H,s), 6.22(2H,s), 7.01-7.32(9H,m), 7.80(1H,s), 8.23(1H,s), 9.03(2H,brs). [0946]

Example 203

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-tert-butyl-2,2-dioxo-2,3-dihydro-1H-benz[1,3,4]oxathiazin-7-yl)-ethanone hydrobromide [0947]
1H-NMR(DMSO-d6) δ: [0948]
1.46(9H,s), 5.05(2H,s), 5.52(2H,s), 5.35-5.43(2H,m), 7.28-7.50(11H,m), 7.19-7.22(1H,m). [0949]

Example 204

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-4-methanesulfonyl-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-ethanone hydrobromide [0950]
1H-NMR(DMSO-d6) δ: [0951]
1.41(9H,s), 3.21(3H,s), 3.84-3.92(2H,m), 4.44-4.51(2H,m), 5.53(2H,s), 5.97(2H,s), 7.18-7.45(7H,m), 7.46-7.52(1H,m), 7.60-7.66(1H,m), 7.73-7.78(1H,m), 8.19-8.24(1H,m), 9.01(2H,brs). [0952]

Example 205

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-tert-butyl-1-methyl-2,2-dioxo-2,3-dihydro-1H-benz[1,3,4]oxathiazin-7-yl)-ethanone hydrobromide [0953]
1H-NMR(DMSO-d6) δ: [0954]
1.42(9H,s), 3.36(3H,s), 5.54(2H,s), 5.65(2H,s), 6.03(2H,s), 7.25-7.37(5H,m), 7.39-7.45(2H,m), 7.48-7.53(1H,m), 7.58-7.65(1H,m), 7.73-7.78(1H,m), 7.80-7.84(1H,m), 8.99(2H,brs). [0955]

Example 206

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-4-hydroxy-5-(2-hydroxy-ethyl)-phenyl]-ethanone hydrobromide [0956]
1H-NMR(DMSO-d6) δ: [0957]
1.40(9H,s), 2.89(2H,t,J=5.2 Hz), 3.74(2H,t,J=5.2 Hz), 5.53(2H,s), 5.93(2H,s), 7.24-7.35(5H,m), 7.36-7.42(2H,m), 7.45-7.50(1H,m), 7.57-7.62(1H,m), 7.79(2H,s). [0958]

Example 207

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-benzyl}-acetamide hydrobromide [0959]
1H-NMR(DMSO-d6) δ: [0960]
1.41(9H,s), 1.94(3H,s), 4.25(2H,d,J=6.0 Hz), 5.55(2H,s), 5.96(2H,s), 7.20-7.42(7H,m), 7.46-7.52(1H,m), 7.56-7.64(1H,m), 7.81(1H,s), 7.87(1H,s), 9.04(2H,s), 9.21(1H,t,J=6.0 Hz). [0961]

Example 208

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-benzyl}-N-methyl-acetamide hydrobromide [0962]
1H-NMR(DMSO-d6) δ: [0963]
1.38(9H,s), 2.11(3H,s), 3.12(3H,s), 4.49(2H,s), 5.54(2H,s), 5.98(2H,s), 7.24-7.35(5H,m), 7.36-7.42(2H,m), 7.45-7.51(1H,m), 7.57-7.63(1H,m), 7.88(1H,s), 7.99(1H,s). [0964]

Example 209

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-benzyl}-methanesulfonamide hydrobromide [0965]
1H-NMR(DMSO-d6) δ: [0966]
1.43(9H,s), 2.95(3H,s), 4.27(2H,s), 5.54(2H,s), 5.96(2H,s), 7.24-7.35(5H,m), 7.36-7.43(2H,m), 7.45-7.50(1H,m), 7.57-7.62(1H,m), 7.86(1H,s), 7.94(1H,s). [0967]

Example 210

Ethanesulfonic acid {5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-methyl-amide hydrobromide [0968]
1H-NMR(DMSO-d6) δ: [0969]
1.30(3H,t,J=7 Hz), 1.42(9H,s), 3.19(9H,s), 3.26-3.38(2H,m), 5.55(2H,s), 5.93(2H,brs), 7.22-7.37(6H,m), 7.39-7.45(2H,m), 7.47-7.53(1H,m), 7.61-7.67(1H,m), 7.83-7.88(1H,m), 7.95-8.01(1H,m), 9.00(2H,brs). [0970]

Example 211

N-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N-methyl-C-phenyl-methanesulfonamide hydrobromide [0971]
1H-NMR(DMSO-d6) δ: [0972]
1.43(9H,s), 3.26(3H,s), 4.70(2H,brs), 5.55(2H,s), 5.99(2H,brs), 7.26-7.47(13H,m), 7.48-7.53(1H,m), 7.63-7.69(1H,m), 7.89-7.94(1H,m), 8.10-8.14(1H,m), 9.02(2H,brs). [0973]

Example 212

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-N,N-dimethyl-benzamide hydrobromide [0974]
1H-NMR(DMSO-d6) 6: [0975]
1.40(9H,s), 3.00(6H,s), 5.53(2H,s), 5.96(2H,s), 7.24-7.42(7H,m), 7.46-7.51(1H,m), 7.58-7.64(1H,m), 7.89(2H,s). [0976]

Example 213

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-N-ethyl-2-hydroxy-N-methyl-benzamide hydrobromide [0977]
1H-NMR(DMSO-d6) δ: [0978]
1.13(3H,t,J=6.8 Hz), 1.42(9H,s), 2.98(3H,s), 3.32-3.48(2H,m), 5.53(2H,s), 5.98(2H,s), 7.25-7.52(8H,m), 7.60-7.66(1H,m), 7.84(1H,s), 7.92(1H,s), 9.03(2H,brs). [0979]

Example 214

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-N-methyl-benzamide hydrobromide [0980]
1H-NMR(DMSO-d6) δ: [0981]
1.41(9H,s), 2.87(3H,d,J=4.0 Hz), 5.54(2H,s), 5.97(2H,s), 7.44-7.65(11H,m), 8.58(1H,brs). [0982]

Example 215

2,2,2-Trifluoro-ethanesulfonic acid {5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-methyl-amide hydrobromide [0983]
1H-NMR(DMSO-d6) δ: [0984]
1.42(9H,s), 3.27(3H,s), 4.50-5.90(2H,m), 5.55(2H,s), 5.38-5.47(2H,m), 7.26-7.37(5H,m), 7.39-7.45(2H,m), 7.48-7.53(1H,m), 7.62-7.68(1H,m), 7.87-7.93(1H,m), 8.02-8.09(1H,m), 9.00(2H,brs), 10.37(1H,brs). [0985]

Example 216

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-[3-tert-butyl-5-(1,1-dioxo-isothiazolidin-2-yl)-4-hydroxy-phenyl]-ethanone hydrobromide [0986]
1H-NMR(DMSO-d6) δ: [0987]
1.38(9H,s), 2.45-2.56(2H,m), 3.46(2H,t,J=7 Hz), 3.83(2H,t,J=7 Hz), 5.60(2H,s), 6.22(2H,s), 7.06-7.38(7H,m), 7.58-7.60(1H,m), 7.92-7.95(1H,m), 8.07-8.11(2H,m), 9.21(2H,brs). [0988]

Example 217

1-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-pyrrolidin-2-one hydrobromide [0989]
1H-NMR(DMSO-d6) δ: [0990]
1.42(9H,s), 2.11-2.22(2H,m), 2.40-2.47(2H,m), 3.65-3.71(2H,m), 5.52(2H,s), 5.91(2H,s), 7.23-7.35(5H,m), 7.36-7.42(2H,m), 7.45-7.51(1H,m), 7.58-7.63(1H,m), 7.79-7.86(2H,m). [0991]

Example 218

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-N,N-dimethyl-benzenesulfonamide hydrobromide [0992]
1H-NMR(DMSO-d6) δ: [0993]
1.42(9H,s), 2.79(6H,s), 5.41(2H,s), 5.93(2H,s), 7.08-7.15(1H,m), 7.20-7.40(8H,m), 8.12(1H,s), 8.15(1H,s), 10.09(1H,s). [0994]

Example 219

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-N-butyl-3-tert-butyl-2-hydroxy-benzamide hydrobromide [0995]
1H-NMR(DMSO-d6) δ: [0996]
0.82(3H,t,J=6.8 Hz), 1.32-1.40(2H,m), 1.47(9H,s), 1.60-1.68(2H,m), 3.88-3.95(2H,m), 5.51(2H,s), 6.08(2H,s), 7.22-7.48(9H,m), 8.19(1H,s), 8.58(1H,s). [0997]

Example 220

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(5-tert-butyl-4-hydroxy-2-methyl-phenyl)-ethanone hydrobromide [0998]
1H-NMR(DMSO-d6) δ: [0999]
1.42(9H,s), 2.36(3H,s), 5.55(2H,s), 5.91(2H,s), 6.76(1H,s), 7.24-7.35(5H,m), 7.36-7.42(2H,m), 7.46-7.52(1H,m), 7.60-7.66(1H,m), 7.88(1H,s), 9.00(2H,s), 10.45(1H,s). [1000]

Example 221

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(7-hydroxy-indan-4-yl)-ethanone hydrobromide [1001]
1H-NMR(DMSO-d6) δ: [1002]
1.94-2.03(2H,m), 2.76(2H,t,J=7.6 Hz), 3.13(2H,t,J=7.6 Hz), 5.55(2H,s), 5.85(2H,s), 6.84(1H,d,J=8.4 Hz), 7.24-7.43(7H,m), 7.46-7.52(1H,m), 7.55-7.60(1H,m), 7.91(1H,d,J=8.4 Hz), 9.05(2H,s), 11.13(1H,s). [1003]

Example 222

Methyl {5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-methylcarbamate hydrobromide [1004]
1H-NMR(DMSO-d6) δ: [1005]
1.44(9H,s), 3.30(3H,s), 3.42(3H,s), 5.53(2H,s), 6.04(2H,s), 7.23-7.43(7H,m), 7.45-7.52(1H,m), 7.58-7.65(1H,m), 7.76-7.79(1H,m), 7.85-7.90(1H,m). [1006]

Example 223

2-{5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-N,N-dimethyl-acetamide hydrobromide [1007]
1H-NMR(DMSO-d6) δ: [1008]
1.40(9H,s), 2.52(6H,s), 3.88(2H,s), 5.54(2H,s), 5.93(2H,s), 7.22-7.62(9H,m), 7.81(1H,s), 7.89(1H,s). [1009]

Example 224

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-4-hydroxy-5-nitro-phenyl)-ethanone hydrobromide [1010]
1H-NMR(DMSO-d6) δ: [1011]
1.40(9H,s), 5.54(2H,s), 5.96(2H,s), 7.25-7.46(7H,m), 7.50(1H,m), 7.63(1H,m), 7.91(1H,d,J=2.4 Hz), 8.54(1H,d,J=2.4 Hz), 8.97(2H,s). [1012]

Example 225

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(3-tert-butyl-4-hydroxy-5-methoxy-phenyl)-ethanone hydrobromide [1013]
1H-NMR(DMSO-d6) δ: [1014]
1.39(9H,s), 3.87(3H,s), 5.48(2H,s), 5.91(2H,s), 7.21-7.45(8H,m), 7.48-7.55(2H,m), 7.58-7.62(1H,m). [1015]

Example 226

Methyl 3-{5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenyl}-propanoate hydrobromide [1016]
1H-NMR(DMSO-d6) 6: [1017]
1.40(9H,s), 2.63(2H,t,J=6.8 Hz), 2.98(2H,t,J=6.8 Hz), 3.61(3H,s), 5.53(2H,s), 5.92(2H,s), 7.24-7.50(8H,m), 7.56-7.62(1H,m), 7.78(2H,s). [1018]

Example 227

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(4-hydroxy-naphthalen-1-yl)-ethanone hydrobromide [1019]
1H-NMR(DMSO-d6) δ: [1020]
2.05(2H,s), 5.57(2H,s), 6.01(2H,s), 7.05(1H,d,J=8.0 Hz), 7.21-7.65(11H,m), 8.28(1H,d,J=8.4 Hz), 8.45(1H,d,J=8.0 Hz), 8.96(1H,d,J=8.4 Hz). [1021]

Example 228

Methyl {5-[2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-phenoxy}-acetate hydrobromide [1022]
1H-NMR(DMSO-d6) 6: [1023]
1.41(9H,s), 3.71(3H,s), 4.94(2H,s), 5.52(2H,s), 5.96(2H,s), 7.44-7.72(11H,m). [1024]

Example 229

1-(4-Acetyl-8-tert-butyl-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-2-(3-benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [1025]
1H-NMR(DMSO-d6) δ: [1026]
1.41(9H,s), 2.32(3H,s), 3.92(2H,t,J=4.4 Hz), 4.49(2H,t,J=4.4 Hz), 5.55(2H,s), 5.96(2H,s), 7.25-7.45(7H,m), 7.50(1H,m), 7.63(1H,m), 7.74(1H,s), 8.30(1H,brs), 9.00(2H,s). [1027]

Example 230

6-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-8-tert-butyl-4-methyl-4H-benz[1,4]oxazin-3-one hydrobromide [1028]
1H-NMR(DMSO-d6) δ: [1029]
1.42(9H,s), 3.39(3H,s), 4.80(2H,s), 5.56(2H,s), 6.07(2H,s), 7.25-7.47(7H,m), 7.52(1H,m), 7.63(1H,m), 7.72(1H,d,J=2.0 Hz), 7.74(1H,d,J=2.0 Hz), 9.02(2H,s). [1030]

Example 231

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-{3-tert-butyl-4-hydroxy-5-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-ethanone hydrobromide [1031]
1H-NMR(DMSO-d6) δ: [1032]
1.43(9H,s), 2.73(3H,s), 2,98(2H,t,J=5.2 Hz), 3.32(3H,s), 3.45(2H,t,J=5.2 Hz), 5.55(2H,s), 5.96(2H,s), 7.27-7.45(7H,m), 7.51(1H,m), 7.64(1H,m), 7.75(1H,d,J=2.0 Hz), 7.86(1H,d,J=2.0 Hz), 8.96(2H,s), 9.20(1H,s). [1033]

Example 232

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-(8-tert-butyl-4-methyl-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-ethanone hydrobromide [1034]
1H-NMR(DMSO-d6) δ: [1035]
1.38(9H,s), 2.95(3H,s), 3.34(2H,t,J=4.4 Hz), 4.37(2H,t,J=4.4 Hz), 5.55(2H,s), 5.97(2H,s), 7.25-7.47(9H,m), 7.50(1H,m), 7.61(1H,m), 8.97(2H,s). [1036]

Example 233

5-[2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-acetyl]-3-tert-butyl-2-hydroxy-benzonitrile hydrobromide [1037]
1H-NMR(DMSO-d6) δ: [1038]
1.28(9H,s), 5.52(2H,s), 5.72(2H,s), 7.23-7.36(5H,m), 7.38-7.44(2H,m), 7.45-7.49(1H,m), 7.52-7.59(2H,m), 7.93-7.98(1H,m), 8.07-8.15(2H,brs). [1039]

Example 234

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-{3-[(2-benzyloxy-ethyl)-methyl-amino]-5-tert-butyl-4-hydroxy-phenyl}-ethanone hydrobromide [1040]
1H-NMR(DMSO-d6) δ: [1041]
1.42(9H,s), 2.72(3H,s), 3.05(2H,t,J=5.2 Hz), 3.57(2H,t,J=5.2 Hz), 4.54(2H,s), 5.55(2H,s), 5.96(2H,s), 7.27-7.47(12H,m), 7.50(1H,m), 7.62(1H,m), 7.75(1H,d,J=2.0 Hz), 7.87(1H,d,J=2.0 Hz), 8.97(2H,s), 9.27(1H,s). [1042]

Example 235

2-(3-Benzyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-1-{3-tert-butyl-4-hydroxy-5-[(2-hydroxy-ethyl)-methyl-amino]-phenyl}-ethanone hydrobromide [1043]
1H-NMR(DMSO-d6) δ: [1044]
1.43(9H,s), 2.71(3H,s), 2.87(2H,t,J=4.8 Hz), 3.60(2H,m), 4.54(2H,s), 5.55(3H,s), 5.98(2H,s), 7.27-7.47(7H,m), 7.50(1H,m), 7.63(1H,m), 7.73(1H,d,J=2.0 Hz), 7.78(1H,d,J=2.0 Hz), 9.00(2H,s), 9.76(1H,s). [1045]

Example 236

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [1046]
1H-NMR(DMSO-d6) δ: [1047]
1.45(18H,s), 3.73(3H,s), 5.94(2H,s), 7.29(1H,dt,J=1.2, 7.6 Hz), 7.36(1H,dt,J=1.2, 7.6 Hz), 7.61(2H,t,J=7.6 Hz), 7.85(2H,s), 8.10(1H,brs), 8.78(1H,brs). [1048]

Example 237

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(3-ethyl-2-imino-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [1049]
1H-NMR(DMSO-d6) δ: [1050]
1.24(3H,t,J=7.2 Hz), 1.45(18H,s), 3.45(2H,q,J=7.2 Hz), 5.90(2H,s), 7.25(1H,t,J=7.2 Hz), 7.30(1H,t,J=7.2 Hz), 7.47(1H,d,J=7.2 Hz), 7.55(1H,d,J=7.2 Hz), 7.85(2H,s), 8.78(1H,m). [1051]

Example 238

1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-(2-imino-3-isopropyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [1052]
1H-NMR(DMSO-d6) δ: [1053]
1.19(6H,d,J=6.4 Hz), 1.44(18H,s), 4.03(1H,m), 5.62(2H,s), 6.81(1H,dd,J=0.8, 8.4 Hz), 6.93(1H,dd,J=0.8, 8.4 Hz), 7.02(1H,d,J=8.4 Hz), 7.20(1H,d,J=8.4 Hz), 7.85(2H,s). [1054]

Example 239

4-{3-tert-Butyl-2-hydroxy-5-[2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-acetyl]-phenoxy}-butylamide hydrobromide [1055]
1H-NMR(DMSO-d6) δ: [1056]
1.42(9H,s), 2.02(2H,quintet,J=6.8 Hz), 2.31(2H,t,J=6.8 Hz), 3.73(3H,s), 4.10(2H,t,J=6.8 Hz), 5.92(2H,s), 6.85(1H,s), 7.27-7.40(2H,m), 7.50-7.65(3H,m), 8.80(1H,brs), 8.78(1H,s), 9.48(1H,s). [1057]

Example 240

1-(3-tert-Butyl-5-dimethylamino-phenyl)-2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [1058]
1H-NMR(DMSO-d6) δ: [1059]
1.35(9H,s), 3.00(6H,s), 3.74(3H,s), 5.98(2H,s), 7.08(1H,t,J=2.0 Hz), 7.19(1H,t,J=2.0 Hz), 7.28-7.42(3H,m), 7.56-7.64(2H,m), 8.83(1H,s) [1060]

Example 241

1-(8-tert-Butyl-4-methyl-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-ethanone hydrobromide [1061]
1H-NMR(DMSO-d6) δ: [1062]
1.38(9H,s), 2.94(3H,s), 3.34(2H,dd,J=4.4, 4.8 Hz), 3.73(3H,s), 4.37(2H,dd,J=3.6, 4.8 Hz), 5.92(2H,s), 7.23-7.40(4H,m), 7.55(1H,d,J=7.2 Hz), 7.61(1H,d,J=7.2 Hz), 8.79(1H,brs). [1063]

Example 242

4-{3-tert-Butyl-2-hydroxy-5-[2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-acetyl]-phenoxy}-butyronitrile trifluoroacetate [1064]
1H-NMR(DMSO-d6) δ: [1065]
1.43(9H,s), 2.11(2H,quintet,J=6.0 Hz), 2.85(2H,t,J=6.0 Hz), 3.73(3H,s), 4.14(2H,t,J=6.0 Hz), 5.92(2H,s), 7.30(1H,t,J=7.2 Hz), 7.37(1H,t,J=7.2 Hz), 7.51(1H,d,J=1.6 Hz), 7.56(1H,d,J=8.0 Hz), 7.58-7.65(2H,m), 8.78(1H,s), 8.80(1H,s), 9.52(1H,s). [1066]

Example 243

{2-tert-Butyl-4-[2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-acetyl]-6-(pyrrolidin-1-yl)-phenoxy}-acetic acid trifluoroacetate [1067]
1H-NMR(DMSO-d6) δ: [1068]
1.42(9H,s), 1.91(4H,m), 3.15(4H,m), 3.73(3H,s), 4.44(2H,s), 5.95(2H,s), 7.30(1H,t,J=7.2 Hz), 7.37(1H,t,J=7.2 Hz), 7.50(1H,d,J=2.0 Hz), 7.57(1H,d,J=2.0 Hz), 7.61(2H,t,J=7.2 Hz), 8.78(1H,s). [1069]

Example 244

4-{2-tert-Butyl-4-[2-(2-imino-3-methyl-2,3-dihydro-benzimidazol-1-yl)-acetyl]-6-(pyrrolidin-1-yl)-phenoxy}-butyric acid trifluoroacetate [1070]
1H-NMR(DMSO-d6) δ: [1071]
1.41(9H,s), 1.92(4H,m), 2.05(2H,m), 2.44(2H,t,J=7.2 Hz), 3.16(4H,m), 3.73(3H,s), 3.89(2H,t,J=7.2 Hz), 5.93(2H,s), 7.30(1H,t,J=7.2 Hz), 7.37(1H,t,J=7.2 Hz), 7.45(1H,d,J=2.0 Hz), 7.54(1H,d,J=2.0 Hz), 7.61(2H,t,J=7.2 Hz), 8.78(1H,s). [1072]

Test Examples

The biochemical activities of compounds of the invention and salts thereof and their actions and effects as medicines (thrombin receptor binding capacity, and platelet aggregation inhibitory action) were evaluated by the following methods. [1073]

Test Example 1

[Receptor Binding Assay][1074]
Blood was sampled from a healthy adult who had taken no drugs for one week, and 3.8% citric acid (a ratio of 1:9 with respect to the blood) was added as an anticoagulant. The mixture was then centrifuged at 100 g for 10 minutes at room temperature to yield platelet rich plasma (PRP). The platelet precipitate obtained by centrifuging the PRP was homogenized with a Dounce homogenizer, and then centrifuged at 40,000 g for 60 minutes to yield platelet membrane. The platelet membrane was suspended in a solution prepared by adding DMSO (dimethyl sulfoxide) at 1% concentration to Buffer 1: a 50 mM Tris-HCl buffer containing 10 mM MgCl[1075] ₂and 1 mM EGTA (ethylene glycol tetraacetic acid), and the suspension was stored at −80° C. Bovine albumin and DMSO were added to Buffer 1 at 0.1% and 20%, respectively, to make a preparation solution for the test compound. The test compounds (20 μl) diluted at various concentrations with the preparation solution were added to a 96-well multiscreen plate. Next, 80 μl of 25 nM [³H]Ala-(4-fluoro)Phe-Arg-(cyclohexyl)Ala-(homo)Arg-Tyr-NH₂(high affinity TRAP) diluted with Buffer 1 was added and thoroughly mixed therewith. After then adding 100 μl of the previously prepared platelet membrane suspension (0.4 mg/ml) and mixing, incubation was performed at 37° C. for 1 hour. The reaction mixture was suction filtered and then rinsed 3 times with 200 μl of Buffer 1. Next, 30 μl of liquid scintillator was added for measurement of the radioactivity of the plate using a Top Counter (Packard), the value of the radioactivity in the presence of the test compound minus non-specific binding portion was divided by the specific binding value (the value of the binding in the absence of the compound minus the non-specific binding portion) to determine the binding ratio, from which the IC₅₀value was calculated. The non-specific binding was the value obtained with addition of 10 μM of high affinity TRAP. The results are shown in Table 1.

Test Example 2

[Inhibitory Effects on Platelet Aggregation using Platelet Rich Plasma][1076]

Blood was sampled from a healthy adult who had taken no drugs for one week, and 3.8% citric acid (a ratio of 1:9 with respect to the blood) was added as an anticoagulant. The mixture was then centrifuged at 100 g for 10 minutes at room temperature to yield platelet rich plasma (PRP). The PRP-removed blood was further centrifuged at 1000 g for 10 minutes to yield platelet poor plasma (PPP). The number of platelet was counted using a multi-parameter automatic hemocyte counter (K4500, Sysmex), and the PRP was diluted to approximately 300,000/μl with the PPP. The platelet aggregation activity was determined in the following manner using an Aggregometer (MC Medical). GPRP—NH ₂(final concentration 1 mM, 25 μl) was added as a fibrin polymerization inhibitor to the PRP (175 μl), after which Ca-free Tyrode solution (control) or the test compound suspension (25 μl) at different concentrations was added, incubation was performed at 37° C. for 3 minutes and then 25 μl of thrombin at the minimum concentration required to produce maximum aggregation (final concentration: optimum concentration among 0.5-1.5 units/ml) was added, for initiation of platelet aggregation. PRP and Ca-free Tyrode solution (control) or the preparation solution at various concentrations were pre-incubated at 37° C. for 60 minutes, prior to the platelet aggregation reaction in some experiments. After addition of thrombin, the aggregation reaction was examined for 6 minutes and the areas under the aggregation curves were compared to determine the inhibition ratio, from which the IC₅₀value was calculated. The results are shown in Table 1.

TABLE 1


			RBA IC₅₀	Thr IC₅₀
Example No.	Compound	Compound name	(μM)	(μM)


Example 40		2-[3-(4-amino-benzyl)-2-imino-2,3-di- hydro-benzimida- zol-1-yl]-1-(3,5-di-tert-bu- tyl-4-hydroxy-phenyl)-ethanone dihydrochloride	0.26	1.3

The compounds of the present invention and salts thereof exhibited excellent thrombin receptor binding capacity in Test Example 1, and especially selective binding capacity with PAR1 thrombin receptor. In addition, the compounds of the invention and salts thereof exhibited excellent platelet aggregation inhibitory action in Test Example 2. [1078]

INDUSTRIAL APPLICABILITY

The present invention provides novel 2-iminoimidazole derivatives represented by the formula (I) and salts thereof. The compounds of the invention represented by the formula (I) and salts thereof exhibit excellent thrombin receptor antagonism and especially selective antagonism for PAR1 thrombin receptors. The compounds of the invention and salts thereof can therefore inhibit cellular response to thrombin which includes platelet aggregation, without inhibiting the catalytic activity of thrombin which converts fibrinogen to fibrin, and can also inhibit vascular smooth muscle proliferation occurring as a result of damage to vascular walls by coronary angioplasty and the like, based on selective inhibition of PAR1. [1079]
Thus the compounds of the invention and salts thereof are useful as thrombin receptor antagonists (especially PAR1 thrombin receptor antagonists), platelet aggregation inhibitors (antithrombotic agents) and smooth muscle cell proliferation inhibitors, while also being useful as therapeutic or prophylactic agents for restenosis during or following angioplasty, unstable angina, stable angina, myocardial infarction, cerebral infarction, peripheral arterial occlusion and the like, as therapeutic or prophylactic agents for venous thromboses such as deep venous thrombosis, pulmonary embolism and cerebral embolism accompanying atrial fibrillation, glomerulonephritis and the like, as anti-inflammatory agents or as anti-restenosis agents. [1080]

Claims

1. A compound represented by the formula:

{wherein ring C represents an optionally substituted aromatic hydrocarbon ring or pyridine ring; R¹represents (1) hydrogen, (2) cyano, (3) halogen or (4) a group selected from Substituent Group A below; R²⁰¹represents (1) hydrogen or (2) a group selected from Substituent Group D below; R⁶represents (1) hydrogen, (2) C_1-6alkyl, (3) acyl, (4) carbamoyl, (5) hydroxyl, (6) C_1-6alkoxy, (7) C_1-6alkyloxycarbonyloxy, (8) C_3-8cycloalkyl, (9) C_1-6alkyloxycarbonyl optionally substituted with acyloxy or (10) a C_6-14aromatic hydrocarbon ring group or a 5- to 14-membered aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group E below); Y¹represents a single bond, —(CH₂)_m—, —CR⁸—, —CR⁸R⁹—, —CH₂CO—, —NR⁸—, —SO—, —SO₂—, —CO—, —CONR⁸—or —SO₂NR⁸— [wherein m represents an integer of 1 to 3, and R⁸and R⁹are the same or different and each independently represents hydrogen, halogen, C_1-6alkyl, carboxyl or C_1-6alkoxycarbonyl]; Y²represents a single bond, O, N, —(CH₂)_m—, —CR⁸—, CR⁸R⁹, —CO—, —SO—, —SO₂— or —C(═N—OR⁸)— [wherein m, R⁸and R⁹have the same definitions given above]; and Ar represents (1) hydrogen, (2) a group represented by the formula:

[wherein R¹⁰, R¹¹, R¹², R¹³and R¹⁴are the same or different and each independently represents (1) hydrogen, (2) cyano, (3) halogen, (4) nitro or (5) a group selected from Substituent Group B below, and R¹¹and R¹²or R¹²and R¹³may bond together to form a 5- to 8-membered heterocycle optionally having 1 to 4 hetero atoms selected from N, S and O and optionally substituted with at least one group selected from Substituent Group F below] or (3) a 5- to 14-membered aromatic heterocyclic group optionally substituted with at least one group selected from Substituent Group G below; wherein

<Substituent Group A> represents moieties selected from the group consisting of C_1-6alkyl, alkylidene, C_2-6alkenyl, C_2-6alkynyl, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, sulfonylamino, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A′ below;

<Substituent Group A′> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen, C_3-8cycloalkyl, a heterocyclic alkyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C_6-14aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C_1-6alkyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C_3-8cycloalkyl;

<Substituent Group B> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6aminoalkyl, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group B′ below;

<Substituent Group B′> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, oxo, cyano, C_1-6cyanoacyl, C_2-7acyl, C_1-6alkanoyl, benzoyl, aralkanoyl, C_1-6alkoxyalkylcarbonyl, C_1-6hydroxyalkylcarbonyl, carboxyl, C_1-6carboxyalkyl, C_1-6carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C_1-6alkoxycarbonyl, C_1-10alkoxycarbonyl-C_1-6alkyl, C_1-10alkoxycarbonyl-C_1-6alkyloxy, C_1-6monoalkylaminocarbonyl, C_2-6dialkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-10alkoxyalkyl, C_1-10aralkyloxyalkyl, C_1-6hydroxyalkyl, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, phenylsulfonylamino, C_1-6alkylsulfonyl, phenylsulfonyl, C_1-6monoalkylaminosulfonyl, C_2-6dialkylaminosulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C_6-14aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C_1-6aminoalkyl, C_1-6alkylamino, C_1-6dialkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl;

<Substituent Group D> represents moieties selected from the group consisting of cyano, halogen, C_2-8alkenyl, C_2-8alkynyl, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl and C_1-6alkyl optionally substituted with at least one group selected from Substituent Group D′ below;

<Substituent Group D′> represents moieties selected from the group consisting of carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, sulfonylamino, sulfonyl, sulfamoyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group;

<Substituent Group E> represents moieties selected from the group consisting of C_1-6alkyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C_3-8cycloalkyl;

<Substituent Group F> represents moieties selected from the group consisting of (1) hydrogen, (2) cyano, (3) halogen, (4) oxo and (5) C_1-6alkyl, alkenyl, alkynyl, acyl, C_1-6alkanoyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, imino, C_1-6aminoalkyl, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F′ below);

<Substituent Group F′> represents moieties selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, benzyloxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, C_1-6alkylsulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group;

<Substituent Group G> represents moieties selected from the group consisting of C_1-6alkyl, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, sulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl.}

or salt thereof.

2. A compound according to claim 1 or salt thereof, wherein ring C represents a further optionally substituted benzene ring or a further optionally substituted pyridine ring; R¹represents C_1-6alkyl, C_2-6alkenyl or C_1-6alkoxy, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A″ below:

<Substituent Group A″> represents moieties selected from the group consisting of C_1-6alkyl, acyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-6alkylamino, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C_6-14aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C_1-6alkyl, carboxyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, nitro, C_1-6alkylamino, acylamino, sulfonylamino and halogen; R²⁰¹represents a group selected from the group consisting of hydrogen, halogen, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, sulfonylamino and sulfamoyl; R⁶represents a group selected from the group consisting of hydrogen, C_1-6alkyl and C_1-6alkyloxycarbonyl optionally substituted with acyloxy; Y¹represents a single bond or —(CH₂)_m— [wherein m represents an integer of 1 to 3]; Y²represents a single bond or —CO—; and Ar represents hydrogen or a group represented by the formula:

[wherein R¹⁰, R¹¹, R¹², R¹³and R¹⁴are the same or different and each independently represents a group selected from the group consisting of hydrogen, C_1-6alkyl, hydroxyl, C_1-6alkoxy, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, a 5- to 14-membered non-aromatic heterocyclic group and C_1-6alkyloxycarbonyloxy, wherein R¹¹and R¹²or R¹²and R¹³may bond together to form a 5- to 8-membered heterocycle (i) optionally having 1 to 4 hetero atoms selected from N, S and O and (ii) optionally substituted with at least one group selected from the group consisting of cyano, oxo, and C_1-6alkyl, acyl, C_1-6alkanoyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, sulfonyl and a 5- to 14-membered non-aromatic heterocyclic group (each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F″ below; wherein

<Substituent Group F″> represents moieties selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl and C_1-6alkoxy)].

3. A compound according to claim 1 or salt thereof, wherein Y¹is —CH₂—.

4. A compound according to claim 1 or salt thereof, wherein Y²is —CO—.

5. A compound according to claim 1 or salt thereof, wherein Y¹is —CH₂— and Y²is —CO—.

6. A compound according to claim 1 or salt thereof, wherein Y¹is a single bond, Y²is a single bond and Ar is hydrogen.

7. A compound according to claim 1 or salt thereof, wherein Ar is a group represented by the formula:

[wherein R¹⁰, R¹¹, R¹², R¹³and R¹⁴have the same definitions given above are as defined in claim 1].

8. A compound according to claim 7 or salt thereof, wherein R¹⁰and R¹⁴are hydrogen.

9. A compound according to claim 1 or salt thereof, wherein Ar is (1) a group represented by the formula:

[wherein R¹⁰, R¹¹, R¹², R¹³and R¹⁴are as defined in claim 1] or (2) a 5- to 14-membered aromatic heterocyclic group optionally substituted with at least one group selected from Substituent Group G: wherein Substituent Group G is as defined in claim 1.

10. A compound according to claim 9 or salt thereof, wherein R¹⁰and R¹⁴are hydrogen.

11. A compound according to claim 1 or salt thereof, wherein Ar is a group represented by the formula:

[wherein R¹¹and R¹³are as defined in claim 1, and R¹⁵represents (1) hydrogen or (2) a group selected from Substituent Group H below, and R¹¹and R¹⁵may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F and optionally having 1 or 2 hetero atoms selected from N, S and O; wherein

Substituent Group F is as defined in claim 1;

<Substituent Group H> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, acyl, C_1-6alkoxycarbonyl, aminocarbonyl, C_1-6alkylaminocarbonyl, C_3-8cycloalkyl, C_1-6aminoalkyl, sulfonyl, C_3-8cycloalkylamino, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group H′ below;

<Substituent Group H′> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, oxo, cyano, C_1-6cyanoalkyl, C_2-7acyl, C_1-6alkanoyl, benzoyl, aralkanoyl, C_1-6alkoxyalkylcarbonyl, C_1-6hydroxyalkylcarbonyl, carboxyl, C_1-6carboxyalkyl, C_1-6carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C_1-6alkoxycarbonyl, C_1-10alkoxycarbonyl-C_1-6alkyl, C_1-10alkoxycarbonyl-C_1-6alkyloxy, C_1-6monoalkylaminocarbonyl, C_2-6dialkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-10alkoxyalkyl, C_1-10aralkyloxyalkyl, C_1-6hydroxyalkyl, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, phenylsulfonylamino, C_1-6alkylsulfonyl, phenylsulfonyl, C_1-6monoalkylaminosulfonyl, C_2-6dialkylaminosulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C_6-14aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C_1-6aminoalkyl, C_1-6alkylamino, C_1-6dialkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl].

12. A compound according to claim 1 or salt thereof, wherein Ar is a group represented by the formula:

[wherein R¹¹and R¹⁵are as defined in claim 1, and R¹⁶represents (1) hydrogen or (2) a group selected from Substituent Group H, and R¹¹and R¹⁵or R¹⁵and R¹⁶may bond together to form a 5- to 6-membered heterocycle optionally substituted with at least one group selected from Substituent Group F and optionally having 1 or 2 hetero atoms selected from from N, S and O]; wherein

Substituent Groups F and H are as defined in claim 1.

13. A compound according to claim 1 or salt thereof, wherein Ar is a group represented by the formula:

[wherein R¹¹and R¹⁵are as defined in claim 1, and R¹⁷and R¹⁸are the same or different and each independently represents (1) hydrogen or (2) a group selected from Substituent Group I below, and R¹¹and R¹⁵, R¹⁵and R¹⁷, R¹⁵and R¹⁸or R¹⁷and R¹⁸may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F and optionally having 1 or 2 hetero atoms selected from N, S and O, wherein

Substituent Group F is as defined in claim 1;

<Substituent Group I> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, acyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, C_1-6aminoalkyl, sulfonyl, sulfamoyl, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group I′ below;

<Substituent Group I′> represents moieties selected from the group consisting of C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, oxo, cyano, C_1-6cyanoalkyl, C_2-7acyl, C_1-6alkanoyl, benzoyl, aralkanoyl, C_1-6alkoxyalkylcarbonyl, C_1-6hydroxyalkylcarbonyl, carboxyl, C_1-6carboxyalkyl, C_1-6carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C_1-6alkoxycarbonyl, C_1-10alkoxycarbonyl-C_1-6alkyl, C_1-10alkoxycarbonyl-C_1-6alkyloxy, C_1-6monoalkylaminocarbonyl, C_2-6dialkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_1-10alkoxyalkyl, C_1-10aralkyloxyalkyl, C_1-6hydroxyalkyl, C_3-8cycloalkyloxy, amino, C_1-6alkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, C_1-6alkylsulfonylamino, phenylsulfonylamino, C_1-6alkylsulfonyl, phenylsulfonyl, C_1-6monoalkylaminosulfonyl, C_2-6dialkylaminosulfonyl, sulfamoyl, halogeno, C_3-8cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C_6-14aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C_6-14aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C_1-6alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C_1-6alkoxycarbonyl, C_1-6alkylaminocarbonyl, hydroxyl, C_1-6alkoxy, C_3-8cycloalkyloxy, nitro, amino, C_1-6aminoalkyl, C_1-6alkylamino, C_1-6dialkylamino, C_3-8cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C_3-8cycloalkyl].

14. A pharmaceutical composition comprising a compound according to claim 1 or salt thereof.

15. A composition according to claim 14, wherein the composition is useful as a thrombin receptor antagonist.

16. A composition according to claim 14, wherein the composition is useful as a thrombin receptor PAR1 antagonist.

17. A composition according to claim 14, wherein the composition is useful as a platelet aggregation inhibitor.

18. A composition according to claim 14, wherein the composition is useful as a proliferation inhibitor for smooth muscle cells.

19. A composition according to claim 14, wherein the composition is useful as a proliferation inhibitor for endothelial cells, fibroblasts, nephrocytes, osteosarcoma cells, muscle cells, cancer cells and/or glia cells.

20. A composition according to claim 14, wherein the composition is useful as a therapeutic or prophylactic agent for thrombosis, vascular restenosis, deep venous thrombosis, pulmonary embolism, cerebral infarction, heart disease, disseminated intravascular coagulation, hypertension, inflammatory disease, rheumatism, asthma, glomerulonephritis, osteoporosis, neurological disease and/or malignant tumor.

21. Use of a compound according to claim 1 or salt thereof for the manufacture of a thrombin receptor antagonist.

22. Use according to claim 21, wherein the thrombin receptor antagonist is a PAR1 receptor antagonist.

22. Use of a compound according to claim 1 or salt thereof for the manufacture of a platelet aggregation inhibitor.

24. A therapeutic method for treating or preventing a disease associated with thrombin receptors, comprising administering to a patient suffering from the disease, a therapeutically effective dose of a compound according to claim 1 or salt thereof.

25. A therapeutic method for treating or preventing a proliferative disease of endothelial cells, fibroblasts, nephrocytes, osteosarcoma cells, muscle cells, cancer cells and/or glia cells, comprising administering to a patient suffering from the disease, a therapeutically effective dose of a compound according to claim 1 or salt thereof.