US20030009209A1 - Bifurcated axially flexible stent - Google Patents

Bifurcated axially flexible stent Download PDF

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Publication number
US20030009209A1
US20030009209A1 US10/180,405 US18040502A US2003009209A1 US 20030009209 A1 US20030009209 A1 US 20030009209A1 US 18040502 A US18040502 A US 18040502A US 2003009209 A1 US2003009209 A1 US 2003009209A1
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United States
Prior art keywords
balloon
guidewire lumen
stent
distal
proximal
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Abandoned
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US10/180,405
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Hikmat Hojeibane
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Individual
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Individual
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Priority claimed from US08/934,974 external-priority patent/US5938682A/en
Priority claimed from US09/028,383 external-priority patent/US6017363A/en
Application filed by Individual filed Critical Individual
Priority to US10/180,405 priority Critical patent/US20030009209A1/en
Publication of US20030009209A1 publication Critical patent/US20030009209A1/en
Abandoned legal-status Critical Current

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Definitions

  • this invention relates to balloon catheters. More specifically, this invention relates to balloon catheters used for stent delivery. Most specifically, this invention relates to balloon catheters useful for delivering bifurcated stents. In particular, this invention relates to balloon catheters, which deliver stents to an arterial bifurcation.
  • a steno is commonly used as a tubular structure left inside the lumen of a duct to relieve an obstruction.
  • stents are inserted into the lumen in a non expanded form and are then expanded autonomously (or with the aid of a second device in situ.
  • a typical method of expansion occurs through the use of a catheter mounted angioplasty balloon which is inflated within the stenosed vessel or body passageway in order to shear and disrupt the obstructions associated with the wall components of the vessel and to obtain an enlarged lumen.
  • stents are described as longitudinally flexible but consist of a plurality of cylindrical elements connected by flexible members.
  • This design has at least one important disadvantage for example, according to this design, protruding edges occur when the stent is flexed around a curve raising the possibility of inadvertent retention of the stent on plaque deposited on arterial walls. This may cause the stent to embolize or more out of position and further cause damage to the interior lining of healthy vessels. (See FIG. 1( a ) below).
  • stents known in the art which may be expanded by balloon angioplasty, generally compromise axial flexibility to permit expansion and provide overall structural integrity.
  • Catheter balloons and medical devices incorporating them are well known for use in the surgical arena. For instance, during angioplasty, stenoses and/or obstructions in blood vessels and other body passageways are altered, in order to increase blood flow through the obstructed area of the blood vessel. For example, in a typical balloon angioplasty procedure, a partially occluded lumen is enlarged through the use of a balloon catheter that is passed percutaneously by way of the arterial system by way to the site of the vascular obstruction. The balloon is then deflated to dilate the vessel lumen at the site of the obstruction.
  • a “scaffolding,” or stent placed on the balloon angioplasty catheter for similar delivery through the arterial system to the site of a vascular obstruction. Thereafter, the balloon angioplasty catheter is inflated, thereby expanding the stent placed on the catheter. When the stent expands, r similarly expands the lumen so that after removal of the deflated catheter, the stent is retained in its expanded position and thereby holds open that formerly obstructed area of the body passageway.
  • a balloon catheter is a thin, flexible length of tubing having a small inflatable balloon at a desired location along its length such as at or near its tip.
  • Balloon catheters are designed to be inserted into a body passageway such as the lumen of a blood vessel, a passageway in the heart, a urological passageway, and the like.
  • the passage of the balloon catheter into the body passageway is done with guidance, such as x-ray or fluoroscopic guidance.
  • stent delivery is quite complex. That is, a stent is sometimes required to be placed in a rather tortuous area of the vasculature. In this instance, it is often necessary to have a catheter which is capable of negotiating tight turns, and/or being placed along a bifurcated length of blood vessel. In some instances, while a generally occluded section of blood vessel can readily be stented, it is often difficult to place a second stent at the other portion of a bifurcation. In other words, one can imagine the bifurcation as an inverted letter “Y” within the body.
  • a device such as a desired delivery system to carry a stent capable of allowing secondary access to a bifurcated portion of the vasculature.
  • the device would be most desirable for the device to comprise a catheter capable of balloon delivery of a stent at a bifurcation, and also balloon delivery of a second stent at the bifurcation.
  • the present invention overcomes some perceived shortcomings of prior art stents by providing a stent with axial flexibility.
  • the stent has a first end and a second end with an intermediate section between the two ends.
  • the stent further has a longitudinal axis and comprises a plurality of longitudinally disposed bands, wherein each band defines a generally continuous wave along a line segment parallel to the longitudinal axis.
  • a plurality of links maintains the bands in a tubular structure.
  • each longitudinally disposed band of the stent is connected, at a plurality of periodic locations, by a short circumferential link to an adjacent band.
  • the wave associated with each of the bands has approximately the same fundamental spatial frequency in the intermediate section, and the bands are so disposed that the waves associated with them are spatially aligned so as to be generally in phase with one another.
  • the spatially aligned bands are connected, at a plurality of periodic locations, by a short circumferential link to an adjacent band.
  • each one of a second group of common axial positions there is a circumferential link between each of a second set of adjacent rows of bands, wherein, along the longitudinal axis, a common axial position occurs alternately in the first group and in the second group, and the first and second sets are selected so that a given band is linked to a neighboring band at only one of the first and second groups of common axial positions.
  • the spatial frequency of the wave associated with each of the bands is decreased in a first end region lying proximate to the first end and in a second end region lying proximate to the second end, in comparison to the spatial frequency of the wave in the intermediate section.
  • the spatial frequency of the bands in the first and second end regions is decreased by 20% compared with the spatial frequency of the bands in the intermediate section.
  • the first end region may be located between the first end and a set of circumferential links lying closest to the first end and the second end region lies between the second end and a set of circumferential links lying closest to the second end.
  • Each band includes a terminus at each of the first and second ends and the adjacent pairs of bands are joined at their termini to form a closed loop.
  • a stent in a further embodiment of the invention, has first and second ends with an intermediate section therebetween, the stent further having a longitudinal axis and providing axial flexibility.
  • This stent includes a plurality of longitudinally disposed bands, wherein each band defines a generally continuous wave having a spatial frequency along a line segment parallel to the longitudinal axis, the spatial frequency of the wave associated with each of the bands being decreased in a first end region lying proximate to the first end and in a second end region lying proximate to the second end, in comparison to the spatial frequency of the wave in the intermediate section; and a plurality of links for maintaining the bands in a tubular structure.
  • the first and second regions have been further defined as the region that lies between the first and second ends and a set of circumferential links lying closest to the first end and second end.
  • the widths of the sectionals of the bands are greater in the first and second end regions than in the intermediate section.
  • the stent is divided into a group of segments, and each of the segments are connected by a flexible connector.
  • the stent segments are provided with enhanced flexibility at the flexible connectors, due to the geometrical configuration of the flexible connectors.
  • the current stent can be modified to provide for bifurcated access, whereas the stent itself is uniform throughout. If the manufacturer designs such a stent to have an essential opening, then it is possible to place the stent such that a pair of stents can be placed one through The other. In this fashion, the stents are capable of being placed at a bifurcation, without any welding or any special attachments.
  • the interlocking mechanism can be incorporated into the stent design to cause the scent to interlock at the desired position during assembly of the device.
  • the current catheter device consists of a balloon catheter which comprises a shaft portion having a proximal and a distal end.
  • the shaft portion has a guidewire lumen therethrough.
  • the lumen has a proximal opening and a distal opening.
  • the distal opening of the shaft portion is located at the distal end of the shaft.
  • a balloon is connected to the shaft at the shaft distal end.
  • the balloon has proximal and distal ends and a first guidewire lumen through it.
  • the balloon guidewire is in fluid communication with the guidewire lumen of the shaft and the first balloon guidewire lumen also has proximal and distal ends.
  • the balloon has a second guidewire lumen, the second guidewire lumen containing a distal opening located proximal to the distal opening of the first guidewire lumen.
  • a method of stent placement which comprises first guiding a guidewire through the vasculature. Second, a balloon catheter which contains two guidewire lumens is strung along the guidewire into position at the bifurcation. The distal opening of the second guidewire lumen abuts the proximal end of the bifurcation. Thereafter, a second guidewire is strung through the first balloon catheter and out the distal opening of the second guidewire lumen. Thus, resident in the second bifurcation leg is the second guidewire. Then, a second standard stent delivery balloon catheter is guided along the second guidewire to a position within the bifurcation. Typically, expansion of both stents can be done one right after the other after proper placement of the first and second balloons.
  • FIGS. 1 ( a ) and 1 ( b ) are side views of a stent having circumferentially disposed bands wherein the stent is in axially unbent and bent positions respectively, the latter showing protruding edges;
  • FIGS. 1 ( c ) and 1 ( d ) are side views of an axially flexible stent in accordance with the present invention wherein the stent Is in unbent and bent positions respectively, the latter displaying an absence of protruding edges;
  • FIG. 2 is a side view of a portion of the stent of FIGS. 1 ( c ) and 1 ( d ) showing the longitudinal bands, spaces, and inner radial measurements of bends in the bands being measured in inches;
  • FIGS. 3 ( a ) and 3 ( b ) show a portion of the stent of FIG. 2 with two bands between two circumferential links (a) before expansion in the unexpanded state; and (b) after expansion, in the deformed state;
  • FIG. 4 is a view along the length of a piece of cylindrical stent (ends not shown) prior to expansion showing the exterior surface of the cylinder of the stent and the characteristic banding pattern;
  • FIG. 5 is an isometric view of a deflection plot where the stent of FIG. 2 is expanded to a larger diameter of 5 mm;
  • FIG. 6 shows a two-dimensional layout of the stent of FIG. 4 to form a cylinder such that edge “A” meets edge “B”, and illustrating the spring-like action provided in circumferential and longitudinal directions;
  • FIG. 7 shows a two dimensional layout of the stent. The ends are modified such that the length (L A ) is about 20% shorter than length (L B ) and the width of the band A is greater than the width of band B;
  • FIG. 8 shows a perspective view of a stent containing flexible connectors as described in the present invention
  • FIG. 9 shows a stent in which the flexible connectors are attached to stent segments, in layout form. These flexible connectors are attached in an every-other-segment pattern;
  • FIG. 10 shows a layout view where the stent segments are connected with a flexible connector in every stent segment pattern
  • FIG. 11 shows a schematic of the unexpanded stents when loaded on the stent delivery system
  • FIG. 12 shows the stents placed alone
  • FIG. 13 shows the stents as expanded without the delivery system
  • FIG. 14 shows a modification of the stent in a layout view
  • FIG. 15 is a plan view of the balloon of the present system.
  • FIG. 16 is an assembly view of the same balloon
  • FIG. 17 is a view of the balloon when in use
  • FIG. 18 is a assembly view of another stent which may be used on the balloons of FIGS. 15 - 17 ;
  • FIG. 19 is a plan view of the stent of the previous figure.
  • Improvements afforded by embodiments of the present invention include (a) increased flexibility in two planes of the non-expanded stent while maintaining radial strength and a high percentage open area after expansion; (b) even pressure on the expanding stent that ensures the consistent and continuous contact of expanded stent against artery wall; (c) avoidance of protruding parts during bending; (d) removal of existing restrictions on maximum of stent; and reduction of any shortening effect during expansion of the stent.
  • an expandable cylindrical stent 10 having a fenestrated structure for placement in a blood vessel, duct or lumen to hold the vessel, duct or lumen open, more particularly for protecting a segment of artery from restenosis after angioplasty.
  • the stent 10 may be expanded circumferentially and maintained in an expanded configuration, that is circumferentially rigid.
  • the stent 10 is axially flexible and when flexed at a band, the stent 10 avoids any externally protruding component parts.
  • FIG. 1 shows what happens to a stent 10 , of a similar design to a preferred embodiment herein but utilizing instead a series of circumferentially disposed bands, when caused to bend in a manner that is likely encountered within a lumen of the body.
  • a stent 10 with a circumferential arrangement of bands ( 1 ) experiences an effect analogous to a series of railroad cars on a track. As the row of railroad cars proceeds around the bend, the corner of each car proceeding around the bend after the coupling is caused to protrude from the contour of the track.
  • the serpentine circumferential bands have protrusions ( 2 ) above the surface of the stent 10 as the stent 10 bends.
  • FIGS. 1 ( c ) and 1 ( d ) and FIG. 7 has bands ( 3 ) which are axially flexible and are arranged along the longitudinal axis. This allows the stent to bend so that the bent bands ( 4 ) do not protrude from the profile of the curve of the stent 10 . Furthermore, any flaring at the ends of the stent 10 that might occur with a stent 10 having a uniform structure is substantially eliminated by introducing a modification at the ends of the stent 10 . This modification comprises decreasing the spatial frequency and increasing the width of the corresponding bands in a circumferential direction (L A and A) compared to that of the intermediate section. (l B and B).
  • the spatial frequency L A may be decreased 0-50% with respect to L B , and the width A may be increased in the range of 0-150% with respect to B.
  • Other modifications at the ends of the stent 10 may include increasing the thickness of the wall of the stent 10 and selective electropolishing. These modifications protect the artery and any plaque from abrasion that may be caused by the stent 10 ends during insertion of the stent 10 . The modification also may provide increased radio-opacity at the ends of the stent 10 . Hence it may be possible to more accurately locate the stent 10 once it is in place in the body.
  • FIGS. 2 and 6 has the unique advantage of possessing effective “springs” in both circumferential and longitudinal directions shown as items ( 5 ) and ( 6 ) respectively. These springs provide the stent 10 with the flexibility necessary both to navigate vessels in the body with reduced friction and to expand at the selected site in a manner that provides the final necessary expanded dimensions without undue force while retaining structural resilience of the expanded structure.
  • each longitudinal band undulates through approximately two cycles before there is formed a circumferential link to an adjacent band.
  • the wave W associated with each of the bands may have approximately the same fundamental spatial frequency, and the bands are so disposed that the wave W associated with them are spatially aligned, so as to be generally in phase with one another as shown in FIG. 6.
  • the aligned bands on the longitudinal axis are connected at a plurality of periodic locations, by a short circumferential link to an adjacent band.
  • a first common axial position such as shown by the line X-X in FIGS. 4 and 6.
  • an adjacent pair of bands is joined by circumferential link 7 .
  • other pairs of bands are also linked at this common axial position.
  • a second common axial position shown in FIG. 6 by the line Y-Y
  • an adjacent pair of bands is joined by circumferential link 8 .
  • any given pair of bands that is linked at X-X is not linked at Y-Y and vice-versa.
  • the X-X pattern of linkages repeats at the common axial position Z-Z.
  • a feature of the expansion event is that the pattern of open space in the stent 10 of :he embodiment of FIG. 2 before expansion is different r mm the pattern of the stent 10 after expansion.
  • he pattern of open space on the stent 10 before expansion is serpentine, whereas after expansion, the pattern approaches a diamond shape ( 3 a , 3 b ).
  • expansion may be achieved using pressure from an expanding balloon or by other mechanical means.
  • FIG. 3 shows how radial expansion of the stent 10 causes the fenestrations to open up into a diamond shape with maximum stress being expended on the apices of the diamond along the longitudinal axis.
  • the optimization of strain of the stent 10 is achieved by creating as large a turn radius as possible in the wave W associated with each band in the non-expanded stent 10 . This is accomplished while preserving a sufficient number of bands and links to preserve the structural integrity of the stent 10 after expansion.
  • the strain may be less than 0.57 inches/Inch for 316L stainless steel.
  • the expansion pressure may be 1.0-7.0 atmospheres.
  • the number of bands and the spatial frequency of the wave W on the longitudinal axis also affect the number of circumferential links.
  • the circumferential links contribute structural integrity during application of radial force used in expansion of the stent 10 and in the maintenance of the expanded form.
  • examples of a stent 10 of the invention having a longitudinal axis and providing axial flexibility of the type shown in FIG. 6, may include the following: stents 10 having an expanded diameter of 4 mm and a length of 30 mm that for example may have about 8-12 rows, more particularly 10 rows; about 6-10 slots, more particularly 8 slots (a slot is shown in FIG. 6 as extending between X and Z); and a wave W amplitude of about 1 ⁇ 4- ⁇ fraction (1/10) ⁇ of a slot length, more particularly 1 ⁇ 8 of a slot length.
  • the stents described may be fabricated from many methods.
  • the stents may be fabricated from a hollow or formed stainless steel tube that may be cut out using lasers, electric discharge milling (EDM), chemical etching or other means.
  • EDM electric discharge milling
  • the stents are inserted into the body and placed at the desired site in an unexpanded form.
  • expansion of the stent is effected in a blood vessel by means of a balloon catheter, where the final diameter of the stent is a function of the diameter of the balloon catheter used.
  • the stent of the invention can be made at any desired length, most preferably at a nominal 30 mm length that can be extended or diminished by increments, for example 1.9 mm increments.
  • a stent in accordance with the present invention may be embodied in a shape memory material, including, for example, an appropriate alloy of nickel and titanium; or stainless steel.
  • the stent may be compressed so as to occupy a space sufficiently small as to permit its insertion in a blood vessel or other tissue by insertion means, wherein the insertion means include a suitable catheter, or flexible rod.
  • the stent On emerging from the catheter, the stent may be configured to expand into the desired configuration where the expansion is automatic or triggered by a change in pressure, temperature or electrical stimulation.
  • An embodiment of the improved stent has utility not only within blood vessels as described above but also in any tubular system of the body such as the bile ducts, the urinary system, the digestive tube, and the tubes of the reproductive system in both men and women.
  • a stent 10 as presently disclosed containing a multiplicity of curvilinear segments 20 .
  • These curvilinear segments 20 are connected to each other via a generally perpendicular connector 25 .
  • the generally perpendicular connector 25 lies substantially in the plane perpendicular to the longitudinal axis of the scent 10 .
  • Each of the stent 10 segments as described herein is connected to an adjacent stent 10 segment. This is done using a series of flexible connectors.
  • the connectors themselves can be made narrower at their midpoints. This enhances the possibility of flexure at that point.
  • alternate designs of the connector to insure flexibility are possible, and contemplated by this invention.
  • the stent 10 as described in FIG. 8 is a stent 10 of considerable flexibility when compared to more rigid rectilinear stents. Nonetheless, the stent 10 of the present invention does not depart from the basic concepts set forth herein, in that it discloses a continuously curvilinear strut. This curvilinear strut is connected to other curvilinear struts via a series of “second” more flexible connectors, described above.
  • the stent 10 of the present invention incorporates various new and useful members.
  • One of them is the flexible connector in conjunction with a generally curvilinear stent.
  • Another is the use of the generally larger struts at the ends of the stent 10 in order to provide for continued support at the stent 10 ends.
  • a final aspect is the use of flexible connectors amongst stent 10 segments to provide for greater flexibility.
  • an improved device 100 of the present invention can also be made to perform in a bifurcated fashion.
  • the stent 101 contains a central opening 102 .
  • This central opening 102 allows for the passage of an unexpanded stent 103 of the same size.
  • the two stents 101 , 103 will have the same general configuration, and one can pass through the other on the same type of diameter balloon.
  • the balloon 150 as seen in the current FIGS. 11 - 16 is a bifurcated balloon, but need not be. Two separate balloons are certainly capable of performing the same function.
  • the balloons are preferably less than 6 Fr in their unexpanded shape in a preferred embodiment, but of course, need not be so constrained.
  • the first stent 101 (the lower one in the figure) is loaded on one of the balloons 151 . It has an opening 102 central to it. This opening faces the upper stent 103 and balloon 152 , the upper stent 102 loaded on the second balloon 152 .
  • the upper stent 103 when loaded on the second balloon 152 also has an opening 104 which faces the lower stent 101 .
  • the second stent 103 is strung through the first stent 101 , it is placed in such a fashion so as to have a mutually acing contact with the first stent 101 .
  • the devices will go toward a bifurcation. When this happens, the device is caused to split using various guide wire techniques. Then, each of the respective balloons is inflated.
  • the stent of FIGS. 11 - 14 can be designed with any slot or wire configurations or of any high density materials or composites and can be balloon expandable or self-expanding or even the combination of both.
  • the devices can be sold separately from separate catheters to be assembled during the desired procedure by the clinicians; can be used with a bifurcated balloon or two separate balloons; or incorporated with one or more radio-opaque markers to allow for better positioning in radio-opacity.
  • the bifurcated stent delivery system is placed by crimping over two balloons and then expanded at the sight of the lesion.
  • a balloon 510 in which is contained a standard balloon catheter 520 .
  • These catheters are described In, for instance, U.S. Pat. Nos. 5,108,415; 5,156,612 and 5,304,197. Such patents are owned by a common assignee of the present invention, and incorporated herein by reference.
  • the current balloon 510 contains a side hole 515 in the balloon.
  • the side hole 515 is placed at an exit port 516 in the middle 517 of the balloon 510 .
  • This side hole 515 creates access to a lumen 525 created in the side of the catheter 510 .
  • this side hole 515 creates an access channel useful for the stent 101 of the current invention.
  • the catheter 510 is advanced into the lumen of the artery, as would be typical angioplasty catheter.
  • a guidewire 550 is placed within lumen 530 of the catheter 510 .
  • the catheter 510 is tracked over the guidewire and into the lumen.
  • the guidewire 550 specially formed for this use is retracted until its tip 555 is placed at the distal marker 535 of the current catheter 516 .
  • the guidewire 550 is rotated so that its tip 555 “pops” out of the side hole 515 created in the side lumen 525 of the present catheter 510 .
  • the guidewire 550 is then advanced through the side branch artery to give access to the side branch.
  • the first item described will be the structure of stent 200 in accordance with the invention and illustrated in FIGS. 18 - 19 .
  • the stent 200 is an improvement over other bifurcated stent ideas, in that the stent is continuous through the mid-section 250 of the main branch segment 210 , 220 .
  • Segment 230 is connected by a weld or other means (such as a pivotable hook or a ball in socket joint) to another section 220 to form the “Y”-shaped stent.
  • Such design will allow for greater vessel coverage at the intersection point of the bifurcation.
  • stent 200 comprises three tubular sections ( 210 , 220 , and 230 ) and a continuous connection ( 240 ).
  • Sections 210 , 220 , 230 have struts 211 , 221 , 231 of sinusoidal shape.
  • any known shape e.g., straight struts, are possible).
  • the first section ( 210 ) is a proximal section having as its center axis L. It is intended for insertion into main stem of blood vessel for treatment upstream of a bifurcation.
  • the first distal section ( 220 ) having as its section axis L′ is at least approximately aligned with proximal section 210 prior to use.
  • This first distal section 220 is intended for insertion to a blood distal branching off from the bifurcation from a proximal blood vessel, into which section 210 is to be placed.
  • the first distal section ( 220 ) is attached to proximal section 210 by some of the omega-shaped connector members 250 seen in FIGS. 18 and 19.
  • Omega-shaped connectors 250 are of different shape than struts 211 , 221 ; these omega-shaped connectors 250 are formed to maximize flexibility, and it is to be understood that these struts need not be limited to the design disclosed here. It is envisioned that other flexible connections are possible.
  • the second distal section ( 230 ) having as its axis L′′ is positioned at the side of the first distal section 220 , and has the advantage of being parallel to the latter prior to use.
  • the second distal section 230 is intended to be inserted into a second distal blood vessel branching off from the bifurcation.
  • connection member 260 which is a weld joint comprising elements 261 , 262 seen in FIG. 18. Dowel 261 fits into hole 262 to form weld 260 .
  • Each of section 210 , 220 , and 230 is preferably formed from a tubular component perforated with a slotted tubular pattern such that the structure of sections 210 , 220 , 230 allows them to expand along their circumferences.
  • section 210 , 220 , and 230 of stent is 200 can be manufactured from extruded cylindrical parts made of a bendable metal alloy such as 316 L stainless steel, but may also be made from other known metals such as nitinol.
  • the external diameter of sections 210 , 220 , 230 typically ranges from 1 mm to 4 mm prior to use, and can be expanded further than 2 mm and 8 mm.
  • Sections 210 , 220 are preferably manufactured from a single tubular part in which flexible connectors, such as omega-shaped connectors 250 are formed via machining.
  • Weld points 261 , 262 are preferably joined by means of, for example, laser welding, or other acceptable alternatives.
  • proximal end 235 of the second distal section 230 may be tapered at the other side of the connector 250 . It extends forward in its peripheral area opposite the omega-shaped connectors 250 . This tapered portion may also be determined by a plane that is inclined with reference to L′ perpendicular to the plane of symmetry of the stent 200 .
  • distal portion 215 of the proximal section 210 is fit together with the proximal ends 225 , 235 , of sections 220 , 230 of the stent, and ensures maximum coverage of the dilated bifurcation area. This is especially true since weld 260 holds the relative position of sections 220 , 230 and the relative positions of sections 210 , 220 is set, and covered by omega-shaped connectors 250 .
  • the whole of the grid of the bifurcated stent 200 covers the proximal and distal portions of the two branching vessels and the whole of the dilated bifurcation area.
  • the stents themselves can be made from any high density material or composite. These stents can be balloon expandable or self-expanding or a combination of both. They can be used on catheters as described herein or on standard catheters.
  • a stent delivery system which consists of an ingeniously modified angioplasty catheter.
  • Typical angioplasty catheters contain a central lumen useful for stringing a guidewire therethrough.
  • the guidewire guides the balloon from a point outside the body, along its length, to a point which is about to be stented.
  • the balloon of the angioplasty catheter holds the stent as it is guided through the vasculature.
  • the balloon is inflated, the stent is similarly inflated, and then the balloon can be deflated.
  • the balloon can be retracted through the vasculature along the guidewire.
  • a second guidewire lumen is placed at least within the balloon. (It should also be realized that the second guidewire lumen also can readily be placed along a length of the catheter shaft.)
  • This second guidewire lumen is useful for attacking the bifurcated vessel. What occurs, therefore, is the following: a large stent is placed on the balloon so modified. Thereafter, the guidewire is tracked through the body to a point past the obstruction, which for the purposes described herein, is presumed to occur at or near a bifurcation. Onto the guidewire is tracked the modified stent delivery system. The balloon guidewire lumen is placed on to the guidewire outside the body and it is then moved along the guidewire to a point inside the body. The exit portion of the second balloon guidewire lumen is somewhere proximal to the distal end of the balloon, so that the entire balloon can be moved to a position along the vasculature at the obstruction in the body passageway.
  • the balloon When the obstruction is reached, the balloon can be inflated. This will usually take care of the “base” and one of the “legs” of the bifurcation.
  • a stent which is associated with the stent delivery system is similarly inflated. This stent has an opening situated along a portion of its wall. This opening is useful for opening the second leg of the bifurcated area.
  • the second area is opened in the following manner: a second balloon angioplasty catheter, this time containing a single basic stent is placed along the guidewire during positioning of the balloon catheter. A second guidewire is then strung through the catheter to a position where it emerges from the second opening. Then, the second catheter is guided along the second guidewire so that it, too, is placed along the second guidewire after the guidewire emerges from the distal opening of the balloon second guidewire opening. Then, the second catheter can be inflated when it is resident in the second “leg” of the bifurcation. At that point, because the first leg has already been expanded and the base of the bifurcation has been expanded, once -he second leg of the bifurcation is expanded, the entire bifurcation has been attended to and the patient is properly stented.
  • a method of stent placement which comprises first guiding a guidewire through the vasculature. Second, a balloon catheter which contains two guidewire lumens is strung along the guidewire into position at the bifurcation. The distal opening of the second guidewire lumen abuts the proximal end of the bifurcation. Thereafter, a second guidewire is strung through the first balloon catheter and out the distal opening of the second guidewire lumen. Thus, resident in the second bifurcation leg is the second guidewire. Then, a second standard stent delivery balloon catheter is guided along the second guidewire to a position within the bifurcation. Typically, expansion of both stents can be done one right after the other after proper placement of the first and second balloons.

Abstract

There is disclosed a method of stent placement which comprises first guiding a guidewire through the vasculature. Second, a balloon catheter which contains two guidewire lumens is strung along the guidewire into position at the bifurcation. The distal opening of the second guidewire lumen abuts the proximal end of the bifurcation. Thereafter, a second guidewire is strung through the first balloon catheter and out the distal opening of the second guidewire lumen. Thus, resident in the second bifurcation leg is the second guidewire. Then, a second standard stent delivery balloon catheter is guided along the second guidewire to a position within the bifurcation. Typically, expansion of both stents can be done one right after the other after proper placement of the first and second balloons.

Description

    CROSS REFERENCE
  • This application is a continuation-in-part of Ser. No. 09/028,383, filed Feb. 24, 1998 which is a continuation-in-part and claims priority from U.S. application Ser. No. 08/934,974, filed Sep. 22, 1997. Ser. No. 08/934,974 claims priority from U.S. Application Serial No. 60/010,686, filed Jan. 26, 1996, now abandoned; and U.S. Application Serial No. 60/017,479, filed Apr. 26, 1996, now abandoned; and U.S. Application Serial No. 60/017,415 filed May 8, 1996; and U.S. Application Serial No. 60/024,110, filed Aug. 16, 1996; and U.S. application Ser. No. 08/770,236, filed Dec. 20, 1996, all such patent applications of which are incorporated herein by reference.[0001]
  • FIELD OF THE INVENTION
  • Generally, this invention relates to balloon catheters. More specifically, this invention relates to balloon catheters used for stent delivery. Most specifically, this invention relates to balloon catheters useful for delivering bifurcated stents. In particular, this invention relates to balloon catheters, which deliver stents to an arterial bifurcation. [0002]
  • BACKGROUND OF THE INVENTION
  • A steno is commonly used as a tubular structure left inside the lumen of a duct to relieve an obstruction. Commonly, stents are inserted into the lumen in a non expanded form and are then expanded autonomously (or with the aid of a second device in situ. A typical method of expansion occurs through the use of a catheter mounted angioplasty balloon which is inflated within the stenosed vessel or body passageway in order to shear and disrupt the obstructions associated with the wall components of the vessel and to obtain an enlarged lumen. [0003]
  • In the absence of a stent, restenosis may occur as a result of elastic recoil of the stenotic lesion. Although a number of stent designs have been reported, these designs have suffered from a number of limitations. These include restrictions on the dimension of the stent such as describes a stent which has rigid ends (8 mm) and a flexible median part of 7-21 mm. This device is formed of multiple pares and is not continuously flexible along the longitudinal axis. Other stent designs with rigid segments and flexible segments have also been described. [0004]
  • Other stents are described as longitudinally flexible but consist of a plurality of cylindrical elements connected by flexible members. This design has at least one important disadvantage for example, according to this design, protruding edges occur when the stent is flexed around a curve raising the possibility of inadvertent retention of the stent on plaque deposited on arterial walls. This may cause the stent to embolize or more out of position and further cause damage to the interior lining of healthy vessels. (See FIG. 1([0005] a) below).
  • Thus, stents known in the art, which may be expanded by balloon angioplasty, generally compromise axial flexibility to permit expansion and provide overall structural integrity. [0006]
  • Catheter balloons and medical devices incorporating them are well known for use in the surgical arena. For instance, during angioplasty, stenoses and/or obstructions in blood vessels and other body passageways are altered, in order to increase blood flow through the obstructed area of the blood vessel. For example, in a typical balloon angioplasty procedure, a partially occluded lumen is enlarged through the use of a balloon catheter that is passed percutaneously by way of the arterial system by way to the site of the vascular obstruction. The balloon is then deflated to dilate the vessel lumen at the site of the obstruction. [0007]
  • Furthermore, another typical procedure uses a “scaffolding,” or stent placed on the balloon angioplasty catheter for similar delivery through the arterial system to the site of a vascular obstruction. Thereafter, the balloon angioplasty catheter is inflated, thereby expanding the stent placed on the catheter. When the stent expands, r similarly expands the lumen so that after removal of the deflated catheter, the stent is retained in its expanded position and thereby holds open that formerly obstructed area of the body passageway. [0008]
  • Essentially, a balloon catheter is a thin, flexible length of tubing having a small inflatable balloon at a desired location along its length such as at or near its tip. Balloon catheters are designed to be inserted into a body passageway such as the lumen of a blood vessel, a passageway in the heart, a urological passageway, and the like. Typically, the passage of the balloon catheter into the body passageway is done with guidance, such as x-ray or fluoroscopic guidance. [0009]
  • In practice, stent delivery is quite complex. That is, a stent is sometimes required to be placed in a rather tortuous area of the vasculature. In this instance, it is often necessary to have a catheter which is capable of negotiating tight turns, and/or being placed along a bifurcated length of blood vessel. In some instances, while a generally occluded section of blood vessel can readily be stented, it is often difficult to place a second stent at the other portion of a bifurcation. In other words, one can imagine the bifurcation as an inverted letter “Y” within the body. (The approach of the catheter concerning this inverted “Y” shape is generally through one of the legs in the “Y”.) Therefore, the balloon passes both between the leg and the trunk or base of the “Y” rather readily. However, once a stent is placed along these two legs, it is rather difficult to place a second stent at or near the junction of the first leg and the base of the letter “Y”. Of course, the same can hold true when the approach is via the base of the “Y” and delivery of the first stent is to one of the legs. This is all the more true because as one advances through the vasculature, the arterial sizes go from quite large (greater than 1 cm diameter) to rather small (some time less than 2.5 mm diameter). [0010]
  • It would be desirable, therefore, to create a system which allows for delivery of a single stent or pair of stents at a bifurcation in the vasculature. It would further be desirable for this stent or for this delivery system to be able to negotiate the bends of the bifurcation, and moreover, to provide for easy access when one stent is already placed. Furthermore, it would be quite useful in order to be able to apply the second stent, for the first stent to be reliably placed every time so that the user knows exactly where the bifurcation is located, and as well where the stent must be appropriately oriented in order to readily access the second leg of the “Y” of the bifurcation. [0011]
  • Finally, it would be useful for a device such as a desired delivery system to carry a stent capable of allowing secondary access to a bifurcated portion of the vasculature. Thus, it would be most desirable for the device to comprise a catheter capable of balloon delivery of a stent at a bifurcation, and also balloon delivery of a second stent at the bifurcation. [0012]
  • SUMMARY OF THE INVENTION
  • The present invention overcomes some perceived shortcomings of prior art stents by providing a stent with axial flexibility. In a preferred embodiment, the stent has a first end and a second end with an intermediate section between the two ends. The stent further has a longitudinal axis and comprises a plurality of longitudinally disposed bands, wherein each band defines a generally continuous wave along a line segment parallel to the longitudinal axis. A plurality of links maintains the bands in a tubular structure. In a further embodiment of the invention, each longitudinally disposed band of the stent is connected, at a plurality of periodic locations, by a short circumferential link to an adjacent band. The wave associated with each of the bands has approximately the same fundamental spatial frequency in the intermediate section, and the bands are so disposed that the waves associated with them are spatially aligned so as to be generally in phase with one another. The spatially aligned bands are connected, at a plurality of periodic locations, by a short circumferential link to an adjacent band. [0013]
  • In particular, at each one of a first group of common axial positions, there is a circumferential link between each of a first set of adjacent pairs of bands. [0014]
  • At each one of a second group of common axial positions, there is a circumferential link between each of a second set of adjacent rows of bands, wherein, along the longitudinal axis, a common axial position occurs alternately in the first group and in the second group, and the first and second sets are selected so that a given band is linked to a neighboring band at only one of the first and second groups of common axial positions. [0015]
  • In a preferred embodiment of the invention, the spatial frequency of the wave associated with each of the bands is decreased in a first end region lying proximate to the first end and in a second end region lying proximate to the second end, in comparison to the spatial frequency of the wave in the intermediate section. In a further embodiment of the invention, the spatial frequency of the bands in the first and second end regions is decreased by 20% compared with the spatial frequency of the bands in the intermediate section. The first end region may be located between the first end and a set of circumferential links lying closest to the first end and the second end region lies between the second end and a set of circumferential links lying closest to the second end. The widths of corresponding sections of the bands in these end regions, measured in a circumferential direction, are greater in the first and second end regions than in the intermediate section. Each band includes a terminus at each of the first and second ends and the adjacent pairs of bands are joined at their termini to form a closed loop. [0016]
  • In a further embodiment of the invention, a stent is provided that has first and second ends with an intermediate section therebetween, the stent further having a longitudinal axis and providing axial flexibility. This stent includes a plurality of longitudinally disposed bands, wherein each band defines a generally continuous wave having a spatial frequency along a line segment parallel to the longitudinal axis, the spatial frequency of the wave associated with each of the bands being decreased in a first end region lying proximate to the first end and in a second end region lying proximate to the second end, in comparison to the spatial frequency of the wave in the intermediate section; and a plurality of links for maintaining the bands in a tubular structure. The first and second regions have been further defined as the region that lies between the first and second ends and a set of circumferential links lying closest to the first end and second end. [0017]
  • In a further embodiment the widths of the sectionals of the bands, measured in a circumferential direction, are greater in the first and second end regions than in the intermediate section. [0018]
  • In yet an additional embodiment, the stent is divided into a group of segments, and each of the segments are connected by a flexible connector. In addition, the stent segments are provided with enhanced flexibility at the flexible connectors, due to the geometrical configuration of the flexible connectors. [0019]
  • Furthermore, the current stent can be modified to provide for bifurcated access, whereas the stent itself is uniform throughout. If the manufacturer designs such a stent to have an essential opening, then it is possible to place the stent such that a pair of stents can be placed one through The other. In this fashion, the stents are capable of being placed at a bifurcation, without any welding or any special attachments. The interlocking mechanism can be incorporated into the stent design to cause the scent to interlock at the desired position during assembly of the device. [0020]
  • In practice, therefore, the current catheter device consists of a balloon catheter which comprises a shaft portion having a proximal and a distal end. The shaft portion has a guidewire lumen therethrough. The lumen has a proximal opening and a distal opening. The distal opening of the shaft portion is located at the distal end of the shaft. A balloon is connected to the shaft at the shaft distal end. The balloon has proximal and distal ends and a first guidewire lumen through it. The balloon guidewire is in fluid communication with the guidewire lumen of the shaft and the first balloon guidewire lumen also has proximal and distal ends. The balloon has a second guidewire lumen, the second guidewire lumen containing a distal opening located proximal to the distal opening of the first guidewire lumen. [0021]
  • Further, there is disclosed a method of stent placement which comprises first guiding a guidewire through the vasculature. Second, a balloon catheter which contains two guidewire lumens is strung along the guidewire into position at the bifurcation. The distal opening of the second guidewire lumen abuts the proximal end of the bifurcation. Thereafter, a second guidewire is strung through the first balloon catheter and out the distal opening of the second guidewire lumen. Thus, resident in the second bifurcation leg is the second guidewire. Then, a second standard stent delivery balloon catheter is guided along the second guidewire to a position within the bifurcation. Typically, expansion of both stents can be done one right after the other after proper placement of the first and second balloons.[0022]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The foregoing aspects of the invention will be more readily understood by reference to the following detailed description, taken with the accompanying drawings, in which: [0023]
  • FIGS. [0024] 1(a) and 1(b) are side views of a stent having circumferentially disposed bands wherein the stent is in axially unbent and bent positions respectively, the latter showing protruding edges;
  • FIGS. [0025] 1(c) and 1(d) are side views of an axially flexible stent in accordance with the present invention wherein the stent Is in unbent and bent positions respectively, the latter displaying an absence of protruding edges;
  • FIG. 2 is a side view of a portion of the stent of FIGS. [0026] 1(c) and 1(d) showing the longitudinal bands, spaces, and inner radial measurements of bends in the bands being measured in inches;
  • FIGS. [0027] 3(a) and 3(b) show a portion of the stent of FIG. 2 with two bands between two circumferential links (a) before expansion in the unexpanded state; and (b) after expansion, in the deformed state;
  • FIG. 4 is a view along the length of a piece of cylindrical stent (ends not shown) prior to expansion showing the exterior surface of the cylinder of the stent and the characteristic banding pattern; [0028]
  • FIG. 5 is an isometric view of a deflection plot where the stent of FIG. 2 is expanded to a larger diameter of 5 mm; [0029]
  • FIG. 6 shows a two-dimensional layout of the stent of FIG. 4 to form a cylinder such that edge “A” meets edge “B”, and illustrating the spring-like action provided in circumferential and longitudinal directions; [0030]
  • FIG. 7 shows a two dimensional layout of the stent. The ends are modified such that the length (L[0031] A) is about 20% shorter than length (LB) and the width of the band A is greater than the width of band B;
  • FIG. 8 shows a perspective view of a stent containing flexible connectors as described in the present invention; [0032]
  • FIG. 9 shows a stent in which the flexible connectors are attached to stent segments, in layout form. These flexible connectors are attached in an every-other-segment pattern; [0033]
  • FIG. 10 shows a layout view where the stent segments are connected with a flexible connector in every stent segment pattern; [0034]
  • FIG. 11 shows a schematic of the unexpanded stents when loaded on the stent delivery system; [0035]
  • FIG. 12 shows the stents placed alone; [0036]
  • FIG. 13 shows the stents as expanded without the delivery system; [0037]
  • FIG. 14 shows a modification of the stent in a layout view; [0038]
  • FIG. 15 is a plan view of the balloon of the present system; [0039]
  • FIG. 16 is an assembly view of the same balloon; [0040]
  • FIG. 17 is a view of the balloon when in use; [0041]
  • FIG. 18 is a assembly view of another stent which may be used on the balloons of FIGS. [0042] 15-17; and
  • FIG. 19 is a plan view of the stent of the previous figure.[0043]
  • DETAILED DESCRIPTION OF SPECIFIC EMBODIMENTS
  • Improvements afforded by embodiments of the present invention include (a) increased flexibility in two planes of the non-expanded stent while maintaining radial strength and a high percentage open area after expansion; (b) even pressure on the expanding stent that ensures the consistent and continuous contact of expanded stent against artery wall; (c) avoidance of protruding parts during bending; (d) removal of existing restrictions on maximum of stent; and reduction of any shortening effect during expansion of the stent. [0044]
  • In a preferred embodiment of the invention, an expandable [0045] cylindrical stent 10 is provided having a fenestrated structure for placement in a blood vessel, duct or lumen to hold the vessel, duct or lumen open, more particularly for protecting a segment of artery from restenosis after angioplasty. The stent 10 may be expanded circumferentially and maintained in an expanded configuration, that is circumferentially rigid. The stent 10 is axially flexible and when flexed at a band, the stent 10 avoids any externally protruding component parts.
  • FIG. 1 shows what happens to a [0046] stent 10, of a similar design to a preferred embodiment herein but utilizing instead a series of circumferentially disposed bands, when caused to bend in a manner that is likely encountered within a lumen of the body. A stent 10 with a circumferential arrangement of bands (1) experiences an effect analogous to a series of railroad cars on a track. As the row of railroad cars proceeds around the bend, the corner of each car proceeding around the bend after the coupling is caused to protrude from the contour of the track. Similarly, the serpentine circumferential bands have protrusions (2) above the surface of the stent 10 as the stent 10 bends.
  • The embodiment shown in FIGS. [0047] 1(c) and 1(d) and FIG. 7 has bands (3) which are axially flexible and are arranged along the longitudinal axis. This allows the stent to bend so that the bent bands (4) do not protrude from the profile of the curve of the stent 10. Furthermore, any flaring at the ends of the stent 10 that might occur with a stent 10 having a uniform structure is substantially eliminated by introducing a modification at the ends of the stent 10. This modification comprises decreasing the spatial frequency and increasing the width of the corresponding bands in a circumferential direction (LA and A) compared to that of the intermediate section. (lB and B).
  • In an embodiment of the invention, the spatial frequency L[0048] A may be decreased 0-50% with respect to LB, and the width A may be increased in the range of 0-150% with respect to B. Other modifications at the ends of the stent 10 may include increasing the thickness of the wall of the stent 10 and selective electropolishing. These modifications protect the artery and any plaque from abrasion that may be caused by the stent 10 ends during insertion of the stent 10. The modification also may provide increased radio-opacity at the ends of the stent 10. Hence it may be possible to more accurately locate the stent 10 once it is in place in the body.
  • The embodiment as shown in FIGS. 2 and 6 has the unique advantage of possessing effective “springs” in both circumferential and longitudinal directions shown as items ([0049] 5) and (6) respectively. These springs provide the stent 10 with the flexibility necessary both to navigate vessels in the body with reduced friction and to expand at the selected site in a manner that provides the final necessary expanded dimensions without undue force while retaining structural resilience of the expanded structure.
  • As shown in both FIGS. 2, 4 and [0050] 6, each longitudinal band undulates through approximately two cycles before there is formed a circumferential link to an adjacent band. Prior to expansion, the wave W associated with each of the bands may have approximately the same fundamental spatial frequency, and the bands are so disposed that the wave W associated with them are spatially aligned, so as to be generally in phase with one another as shown in FIG. 6.
  • The aligned bands on the longitudinal axis are connected at a plurality of periodic locations, by a short circumferential link to an adjacent band. Consider a first common axial position such as shown by the line X-X in FIGS. 4 and 6. Here an adjacent pair of bands is joined by [0051] circumferential link 7. Similarly other pairs of bands are also linked at this common axial position. At a second common axial position, shown in FIG. 6 by the line Y-Y, an adjacent pair of bands is joined by circumferential link 8. However, any given pair of bands that is linked at X-X is not linked at Y-Y and vice-versa. The X-X pattern of linkages repeats at the common axial position Z-Z. In general, there are thus two groups of common axial positions. In each of the axial positions of any one group are links between the same pairs of adjacent bands, and the groups alternate along the longitudinal axis of the embodiment. In this way, circumferential spring 6 and the longitudinal spring 6 are provided.
  • A feature of the expansion event is that the pattern of open space in the [0052] stent 10 of :he embodiment of FIG. 2 before expansion is different r mm the pattern of the stent 10 after expansion. In particular, in a preferred embodiment, he pattern of open space on the stent 10 before expansion is serpentine, whereas after expansion, the pattern approaches a diamond shape (3 a, 3 b). In embodiments of the invention, expansion may be achieved using pressure from an expanding balloon or by other mechanical means.
  • In the course of expansion, as shown in FIG. 3, the wave W shaped bands tend to become straighter. When the bands become straighter, they become stiffer and thereby withstand relatively high radial forces. FIG. 3 shows how radial expansion of the [0053] stent 10 causes the fenestrations to open up into a diamond shape with maximum stress being expended on the apices of the diamond along the longitudinal axis. When finite element analyses including strain studies were performed on the stent 10, it was found that maximum strain was experienced on the bands and links and was below the maximum identified as necessary to maintain structural integrity.
  • The optimization of strain of the [0054] stent 10 is achieved by creating as large a turn radius as possible in the wave W associated with each band in the non-expanded stent 10. This is accomplished while preserving a sufficient number of bands and links to preserve the structural integrity of the stent 10 after expansion. In an embodiment of the invention, the strain may be less than 0.57 inches/Inch for 316L stainless steel. The expansion pressure may be 1.0-7.0 atmospheres. The number of bands and the spatial frequency of the wave W on the longitudinal axis also affect the number of circumferential links. The circumferential links contribute structural integrity during application of radial force used in expansion of the stent 10 and in the maintenance of the expanded form. While not being limited to a single set of parameters, examples of a stent 10 of the invention having a longitudinal axis and providing axial flexibility of the type shown in FIG. 6, may include the following: stents 10 having an expanded diameter of 4 mm and a length of 30 mm that for example may have about 8-12 rows, more particularly 10 rows; about 6-10 slots, more particularly 8 slots (a slot is shown in FIG. 6 as extending between X and Z); and a wave W amplitude of about ¼-{fraction (1/10)} of a slot length, more particularly ⅛ of a slot length.
  • The stents described may be fabricated from many methods. For example, the stents may be fabricated from a hollow or formed stainless steel tube that may be cut out using lasers, electric discharge milling (EDM), chemical etching or other means. The stents are inserted into the body and placed at the desired site in an unexpanded form. In a preferred embodiment, expansion of the stent is effected in a blood vessel by means of a balloon catheter, where the final diameter of the stent is a function of the diameter of the balloon catheter used. [0055]
  • In contrast to stents of the prior art, the stent of the invention can be made at any desired length, most preferably at a nominal 30 mm length that can be extended or diminished by increments, for example 1.9 mm increments. [0056]
  • It will be appreciated that a stent in accordance with the present invention may be embodied in a shape memory material, including, for example, an appropriate alloy of nickel and titanium; or stainless steel. In this embodiment after the stent has been formed, it may be compressed so as to occupy a space sufficiently small as to permit its insertion in a blood vessel or other tissue by insertion means, wherein the insertion means include a suitable catheter, or flexible rod. On emerging from the catheter, the stent may be configured to expand into the desired configuration where the expansion is automatic or triggered by a change in pressure, temperature or electrical stimulation. [0057]
  • An embodiment of the improved stent has utility not only within blood vessels as described above but also in any tubular system of the body such as the bile ducts, the urinary system, the digestive tube, and the tubes of the reproductive system in both men and women. [0058]
  • In yet a further embodiment, there is described a [0059] stent 10 as presently disclosed containing a multiplicity of curvilinear segments 20. These curvilinear segments 20 are connected to each other via a generally perpendicular connector 25. The generally perpendicular connector 25 lies substantially in the plane perpendicular to the longitudinal axis of the scent 10. Each of the stent 10 segments as described herein is connected to an adjacent stent 10 segment. This is done using a series of flexible connectors. Importantly, the connectors themselves can be made narrower at their midpoints. This enhances the possibility of flexure at that point. Of course, it is to be realized that alternate designs of the connector to insure flexibility are possible, and contemplated by this invention.
  • In essence therefore, the [0060] stent 10 as described in FIG. 8 is a stent 10 of considerable flexibility when compared to more rigid rectilinear stents. Nonetheless, the stent 10 of the present invention does not depart from the basic concepts set forth herein, in that it discloses a continuously curvilinear strut. This curvilinear strut is connected to other curvilinear struts via a series of “second” more flexible connectors, described above.
  • In any regard, it can be seen that the [0061] stent 10 of the present invention incorporates various new and useful members. One of them is the flexible connector in conjunction with a generally curvilinear stent. Another is the use of the generally larger struts at the ends of the stent 10 in order to provide for continued support at the stent 10 ends. A final aspect is the use of flexible connectors amongst stent 10 segments to provide for greater flexibility.
  • In all regards, however, it is to be seen that the present invention is to be determined from the attached claims and their equivalents. [0062]
  • As can be seen from FIGS. 11 through 14, an [0063] improved device 100 of the present invention can also be made to perform in a bifurcated fashion. In this way, the stent 101 contains a central opening 102. This central opening 102 allows for the passage of an unexpanded stent 103 of the same size. Typically of course, the two stents 101, 103 will have the same general configuration, and one can pass through the other on the same type of diameter balloon. In fact, the balloon 150 as seen in the current FIGS. 11-16 is a bifurcated balloon, but need not be. Two separate balloons are certainly capable of performing the same function. The balloons are preferably less than 6 Fr in their unexpanded shape in a preferred embodiment, but of course, need not be so constrained.
  • As seen in FIGS. [0064] 11-14, the first stent 101 (the lower one in the figure) is loaded on one of the balloons 151. It has an opening 102 central to it. This opening faces the upper stent 103 and balloon 152, the upper stent 102 loaded on the second balloon 152. The upper stent 103, when loaded on the second balloon 152 also has an opening 104 which faces the lower stent 101. In this fashion, as the second stent 103 is strung through the first stent 101, it is placed in such a fashion so as to have a mutually acing contact with the first stent 101. Then, as the balloon and stent combination is guided through the human anatomy, the devices will go toward a bifurcation. When this happens, the device is caused to split using various guide wire techniques. Then, each of the respective balloons is inflated.
  • On this inflation, the entire device is expanded such as seen in FIG. 13. Thus, the entire bifurcation is covered, and yet in a much easier than typical bifurcated expansions. What is unique is that there is no welding of the [0065] stents 101, 103 together, they can be common “off-the-shelf” stents modified only slightly so as to be useful for this particular need.
  • It should be noted that the stent of FIGS. [0066] 11-14 can be designed with any slot or wire configurations or of any high density materials or composites and can be balloon expandable or self-expanding or even the combination of both. The devices can be sold separately from separate catheters to be assembled during the desired procedure by the clinicians; can be used with a bifurcated balloon or two separate balloons; or incorporated with one or more radio-opaque markers to allow for better positioning in radio-opacity. The bifurcated stent delivery system is placed by crimping over two balloons and then expanded at the sight of the lesion.
  • As seen from FIGS. [0067] 15-17, there is described in this present invention a balloon 510, in which is contained a standard balloon catheter 520. These catheters are described In, for instance, U.S. Pat. Nos. 5,108,415; 5,156,612 and 5,304,197. Such patents are owned by a common assignee of the present invention, and incorporated herein by reference. Uniquely, however, the current balloon 510 contains a side hole 515 in the balloon. The side hole 515 is placed at an exit port 516 in the middle 517 of the balloon 510. This side hole 515 creates access to a lumen 525 created in the side of the catheter 510. Thus, this side hole 515 creates an access channel useful for the stent 101 of the current invention.
  • So in use therefore, the [0068] catheter 510 is advanced into the lumen of the artery, as would be typical angioplasty catheter. First, a guidewire 550 is placed within lumen 530 of the catheter 510. Second, the catheter 510 is tracked over the guidewire and into the lumen. Then, the guidewire 550, specially formed for this use is retracted until its tip 555 is placed at the distal marker 535 of the current catheter 516. Then, the guidewire 550 is rotated so that its tip 555 “pops” out of the side hole 515 created in the side lumen 525 of the present catheter 510. The guidewire 550 is then advanced through the side branch artery to give access to the side branch.
  • In FIGS. [0069] 18-19, the first item described will be the structure of stent 200 in accordance with the invention and illustrated in FIGS. 18-19. The stent 200 is an improvement over other bifurcated stent ideas, in that the stent is continuous through the mid-section 250 of the main branch segment 210, 220. Segment 230 is connected by a weld or other means (such as a pivotable hook or a ball in socket joint) to another section 220 to form the “Y”-shaped stent. Such design will allow for greater vessel coverage at the intersection point of the bifurcation.
  • As was mentioned earlier, [0070] stent 200 comprises three tubular sections (210, 220, and 230) and a continuous connection (240). Sections 210, 220, 230 have struts 211, 221, 231 of sinusoidal shape. Of course, any known shape (e.g., straight struts, are possible).
  • The first section ([0071] 210) is a proximal section having as its center axis L. It is intended for insertion into main stem of blood vessel for treatment upstream of a bifurcation.
  • The first distal section ([0072] 220) having as its section axis L′ is at least approximately aligned with proximal section 210 prior to use. This first distal section 220 is intended for insertion to a blood distal branching off from the bifurcation from a proximal blood vessel, into which section 210 is to be placed. The first distal section (220) is attached to proximal section 210 by some of the omega-shaped connector members 250 seen in FIGS. 18 and 19. Omega-shaped connectors 250, it should be realized, are of different shape than struts 211, 221; these omega-shaped connectors 250 are formed to maximize flexibility, and it is to be understood that these struts need not be limited to the design disclosed here. It is envisioned that other flexible connections are possible.
  • The second distal section ([0073] 230) having as its axis L″ is positioned at the side of the first distal section 220, and has the advantage of being parallel to the latter prior to use. The second distal section 230 is intended to be inserted into a second distal blood vessel branching off from the bifurcation.
  • The two [0074] distal sections 220 and 230 have their proximal ends linked by the connection member 260, which is a weld joint comprising elements 261, 262 seen in FIG. 18. Dowel 261 fits into hole 262 to form weld 260.
  • Each of [0075] section 210, 220, and 230 is preferably formed from a tubular component perforated with a slotted tubular pattern such that the structure of sections 210, 220, 230 allows them to expand along their circumferences.
  • In [0076] practice section 210, 220, and 230 of stent is 200 can be manufactured from extruded cylindrical parts made of a bendable metal alloy such as 316L stainless steel, but may also be made from other known metals such as nitinol. The external diameter of sections 210, 220, 230 typically ranges from 1 mm to 4 mm prior to use, and can be expanded further than 2 mm and 8 mm.
  • [0077] Sections 210, 220 are preferably manufactured from a single tubular part in which flexible connectors, such as omega-shaped connectors 250 are formed via machining.
  • Weld points [0078] 261, 262 are preferably joined by means of, for example, laser welding, or other acceptable alternatives.
  • Furthermore, proximal end [0079] 235 of the second distal section 230 may be tapered at the other side of the connector 250. It extends forward in its peripheral area opposite the omega-shaped connectors 250. This tapered portion may also be determined by a plane that is inclined with reference to L′ perpendicular to the plane of symmetry of the stent 200.
  • After expansion, when the [0080] stent 200 is installed at the a bifurcation of the two vessels, distal portion 215 of the proximal section 210 is fit together with the proximal ends 225, 235, of sections 220, 230 of the stent, and ensures maximum coverage of the dilated bifurcation area. This is especially true since weld 260 holds the relative position of sections 220, 230 and the relative positions of sections 210, 220 is set, and covered by omega-shaped connectors 250.
  • In this way, once in place, the whole of the grid of the [0081] bifurcated stent 200 covers the proximal and distal portions of the two branching vessels and the whole of the dilated bifurcation area.
  • The stents themselves can be made from any high density material or composite. These stents can be balloon expandable or self-expanding or a combination of both. They can be used on catheters as described herein or on standard catheters. [0082]
  • These and other objects of the present invention are accomplished in a stent delivery system which consists of an ingeniously modified angioplasty catheter. Typical angioplasty catheters contain a central lumen useful for stringing a guidewire therethrough. The guidewire then guides the balloon from a point outside the body, along its length, to a point which is about to be stented. The balloon of the angioplasty catheter holds the stent as it is guided through the vasculature. When the obstruction is reached, the balloon is inflated, the stent is similarly inflated, and then the balloon can be deflated. Upon deflation, the balloon can be retracted through the vasculature along the guidewire. [0083]
  • In the present invention, a second guidewire lumen is placed at least within the balloon. (It should also be realized that the second guidewire lumen also can readily be placed along a length of the catheter shaft.) This second guidewire lumen is useful for attacking the bifurcated vessel. What occurs, therefore, is the following: a large stent is placed on the balloon so modified. Thereafter, the guidewire is tracked through the body to a point past the obstruction, which for the purposes described herein, is presumed to occur at or near a bifurcation. Onto the guidewire is tracked the modified stent delivery system. The balloon guidewire lumen is placed on to the guidewire outside the body and it is then moved along the guidewire to a point inside the body. The exit portion of the second balloon guidewire lumen is somewhere proximal to the distal end of the balloon, so that the entire balloon can be moved to a position along the vasculature at the obstruction in the body passageway. [0084]
  • When the obstruction is reached, the balloon can be inflated. This will usually take care of the “base” and one of the “legs” of the bifurcation. When inflated, a stent which is associated with the stent delivery system is similarly inflated. This stent has an opening situated along a portion of its wall. This opening is useful for opening the second leg of the bifurcated area. [0085]
  • The second area is opened in the following manner: a second balloon angioplasty catheter, this time containing a single basic stent is placed along the guidewire during positioning of the balloon catheter. A second guidewire is then strung through the catheter to a position where it emerges from the second opening. Then, the second catheter is guided along the second guidewire so that it, too, is placed along the second guidewire after the guidewire emerges from the distal opening of the balloon second guidewire opening. Then, the second catheter can be inflated when it is resident in the second “leg” of the bifurcation. At that point, because the first leg has already been expanded and the base of the bifurcation has been expanded, once -he second leg of the bifurcation is expanded, the entire bifurcation has been attended to and the patient is properly stented. [0086]
  • Further, there is disclosed a method of stent placement which comprises first guiding a guidewire through the vasculature. Second, a balloon catheter which contains two guidewire lumens is strung along the guidewire into position at the bifurcation. The distal opening of the second guidewire lumen abuts the proximal end of the bifurcation. Thereafter, a second guidewire is strung through the first balloon catheter and out the distal opening of the second guidewire lumen. Thus, resident in the second bifurcation leg is the second guidewire. Then, a second standard stent delivery balloon catheter is guided along the second guidewire to a position within the bifurcation. Typically, expansion of both stents can be done one right after the other after proper placement of the first and second balloons. [0087]

Claims (7)

What is claimed is:
1. A balloon catheter comprising:
a shaft portion having proximal and distal ends, and a guidewire lumen therethrough, said lumen having a proximal opening and a distal opening, the distal opening located at the distal end of said shaft; and
a balloon connected to said shaft at said shaft distal end, said balloon having proximal and distal ends and a first guidewire lumen therethrough, said balloon guidewire lumen in fluid communication with the guidewire lumen of said shaft, said first balloon guidewire lumen having proximal and distal openings; and
a second guidewire lumen, said second guidewire lumen having a distal opening located proximal to the distal opening of said first guidewire lumen.
2. A balloon catheter comprising:
a shaft portion having proximal and distal ends, and a guidewire lumen therethrough, said lumen having a proximal opening and a distal opening, the distal opening located at the distal end of said shaft; and
a balloon connected to said shaft at said shaft distal end, said balloon having proximal and distal ends and a first guidewire lumen therethrough, said balloon guidewire lumen in fluid communication with the guidewire lumen of said shaft, said first balloon guidewire lumen having proximal and distal openings; and
a second guidewire lumen, said second guidewire lumen having a distal opening located proximal to the distal opening of said first guidewire lumen; and the distal opening of the second guidewire lumen contained along the length of the balloon.
3. In combination:
a balloon catheter comprising:
a shaft portion having proximal and distal ends, and a guidewire lumen therethrough, said lumen having a proximal opening and a distal opening, the distal opening located at the distal end of said shaft; and
a balloon connected to said shaft at said shaft distal end, said balloon having proximal and distal ends and a first guidewire lumen therethrough, said balloon guidewire lumen in fluid communication with the guidewire lumen of said shaft, said first balloon guidewire lumen having proximal and distal openings; and
a second balloon catheter comprising;
a second balloon having a second guidewire lumen, said second guidewire lumen having a distal opening located proximal to the distal opening of said first guidewire lumen.
4. In combination:
a balloon catheter comprising:
a shaft portion having proximal and distal ends, and a guidewire lumen therethrough, said lumen having a proximal opening and a distal opening, the distal opening located at the distal end of said shaft; and
a balloon connected to said shaft at said shaft distal end, said balloon having proximal and distal ends and a first guidewire lumen therethrough, said balloon guidewire lumen in fluid communication with the guidewire lumen of said shaft, said first balloon guidewire lumen having proximal and distal openings; and
a second balloon catheter comprising;
a second balloon having a second guidewire lumen, said second guidewire lumen having a distal opening located proximal to the distal opening of said first guidewire lumen; and
a stent comprising a first cylindrical form and a second cylindrical form connected thereto; said second cylindrical form placed alongside a wall portion of the first cylindrical form so that the stent forms a “Y” shaped opening through the interior portion of the stent; and said stent having a welded connection at the connection between said first and second cylinders.
5. In combination:
a balloon catheter comprising:
a shaft portion having proximal and distal ends, and a guidewire lumen therethrough, said lumen having a proximal opening and a distal opening, the distal opening located at the distal end of said shaft; and
a balloon connected to said shaft at said shaft distal end, said balloon having proximal and distal ends and a first guidewire lumen therethrough, said balloon guidewire lumen in fluid communication with the guidewire lumen of said shaft, said first balloon guidewire lumen having proximal and distal openings; and
a second balloon having a second guidewire lumen, said second guidewire lumen having a distal opening located proximal to he distal opening of said first guidewire; and
a guidewire useful for passage through said catheter, said guidewire having a pre-formed curve at its tip.
6. A guidewire useful for passage though a balloon catheter, said guidewire having a curve pre-formed at its tip.
7. In combination:
a balloon catheter comprising:
a shaft portion having proximal and distal ends, and a guidewire lumen therethrough, said lumen having a proximal opening and a distal opening, the distal opening located at the distal end of said shaft; and
a balloon connected to said shaft at said shaft distal end, said balloon having proximal and distal ends and a first guidewire lumen therethrough, said balloon guidewire lumen in fluid communication with the guidewire lumen of said shaft, said first balloon guidewire lumen having proximal and distal openings; and
a second guidewire lumen, said second guidewire lumen having a distal opening located proximal to the distal opening of said first guidewire lumen; and
a stent comprising a first cylindrical form and second cylindrical form;
said second cylindrical form placed alongside a wall portion of the first cylindrical form so that the stent forms a “Y”-shaped opening through the interior portion of the stent.
US10/180,405 1996-01-26 2002-06-26 Bifurcated axially flexible stent Abandoned US20030009209A1 (en)

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US1068696P 1996-01-26 1996-01-26
US1747996P 1996-04-26 1996-04-26
US1741596P 1996-05-08 1996-05-08
US2411096P 1996-08-16 1996-08-16
US08/934,974 US5938682A (en) 1996-01-26 1997-09-22 Axially flexible stent
US09/028,383 US6017363A (en) 1997-09-22 1998-02-24 Bifurcated axially flexible stent
US09/256,580 US6436104B2 (en) 1996-01-26 1999-02-24 Bifurcated axially flexible stent
US10/180,405 US20030009209A1 (en) 1996-01-26 2002-06-26 Bifurcated axially flexible stent

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Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020116047A1 (en) * 1996-11-04 2002-08-22 Vardi Gil M. Extendible stent apparatus and method for deploying the same
US20030195606A1 (en) * 1999-09-23 2003-10-16 Advanced Stent Technologies, Inc., A Delaware Corporation Bifurcation stent system and method
US20040015227A1 (en) * 1996-11-04 2004-01-22 Gil Vardi Extendible stent apparatus
US6706062B2 (en) 1998-01-14 2004-03-16 Advanced Stent Technologies, Inc. Extendible stent apparatus
US20040138737A1 (en) * 1996-11-04 2004-07-15 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US20040148006A1 (en) * 1999-09-23 2004-07-29 Davidson Charles J Stent range transducers and methods of use
US6835203B1 (en) 1996-11-04 2004-12-28 Advanced Stent Technologies, Inc. Extendible stent apparatus
US20050065596A1 (en) * 2002-07-24 2005-03-24 Xufan Tseng Stents capable of controllably releasing histone deacetylase inhibitors
US20050102019A1 (en) * 2003-11-12 2005-05-12 Advanced Stent Technologies, Inc. Catheter balloon systems and methods
US20050102023A1 (en) * 2003-08-21 2005-05-12 Amnon Yadin Stent with protruding branch portion for bifurcated vessels
EP1629861A1 (en) * 2003-06-02 2006-03-01 Nipro Corporation Soft stent with excellent follow-up capability to blood vessel
US20060271159A1 (en) * 2005-05-26 2006-11-30 Boston Scientific Scimed, Inc. Crimpable and expandable side branch cell
US20060271160A1 (en) * 2005-05-26 2006-11-30 Boston Scientific Scimed, Inc. Stent side branch deployment initiation geometry
US20060271161A1 (en) * 2005-05-26 2006-11-30 Boston Scientific Scimed, Inc. Selective treatment of stent side branch petals
WO2007002423A2 (en) * 2005-06-24 2007-01-04 Abbott Laboratories Balloon catheter
US20070055351A1 (en) * 2005-09-08 2007-03-08 Boston Scientific Scimed, Inc. Crown stent assembly
US20070055362A1 (en) * 2005-09-08 2007-03-08 Boston Scientific Scimed, Inc. Overlapping stent
US20070112418A1 (en) * 2005-11-14 2007-05-17 Boston Scientific Scimed, Inc. Stent with spiral side-branch support designs
US20070118205A1 (en) * 1999-01-13 2007-05-24 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US20070129750A1 (en) * 2005-12-05 2007-06-07 Abbott Laboratories Catheter balloon device with internal guidewire lumen and method of formation
US20070135904A1 (en) * 2005-12-14 2007-06-14 Tracee Eidenschink Telescoping bifurcated stent
US20070135903A1 (en) * 2005-12-14 2007-06-14 Daniel Gregorich Connectors for bifurcated stent
US20070142902A1 (en) * 2004-12-14 2007-06-21 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20070203562A1 (en) * 2006-02-22 2007-08-30 Andrzej Malewicz Marker arrangement for bifurcation catheter
US20070208418A1 (en) * 2006-03-06 2007-09-06 Boston Scientific Scimed, Inc. Bifurcated stent
US20070208411A1 (en) * 2006-03-06 2007-09-06 Boston Scientific Scimed, Inc. Bifurcated stent with surface area gradient
US20070208419A1 (en) * 2006-03-06 2007-09-06 Boston Scientific Scimed, Inc. Bifurcation stent with uniform side branch projection
US20070213811A1 (en) * 2006-03-07 2007-09-13 Boston Scientific Scimed, Inc. Bifurcated stent with improvement securement
US20070225796A1 (en) * 2004-03-17 2007-09-27 Boston Scientific Scimed, Inc. Bifurcated stent
US20070233233A1 (en) * 2006-03-31 2007-10-04 Boston Scientific Scimed, Inc Tethered expansion columns for controlled stent expansion
US20080065188A1 (en) * 2006-09-12 2008-03-13 Boston Scientific Scimed, Inc. Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US20080243232A1 (en) * 2007-03-28 2008-10-02 Boston Scientific Scimed, Inc. Bifurcation stent and balloon assemblies
US20080243221A1 (en) * 2007-03-30 2008-10-02 Boston Scientific Scimed, Inc. Balloon fold design for deployment of bifurcated stent petal architecture
US20080255581A1 (en) * 1999-06-04 2008-10-16 Boston Scientific Scimed, Inc. Short sleeve stent delivery catheter and methods
US20090171430A1 (en) * 2007-12-31 2009-07-02 Boston Scientific Scimed, Inc. Bifurcation stent delivery system and methods
US20090275920A1 (en) * 2006-05-11 2009-11-05 Solar Ronald J Systems and methods for treating a vessel using focused force
US20090292241A1 (en) * 2006-06-23 2009-11-26 Abbott Laboratories Balloon catheter
US20090326634A1 (en) * 1996-11-04 2009-12-31 Boston Scientific Scimed, Inc. Methods for deploying stents in bifurcations
US7655030B2 (en) 2003-07-18 2010-02-02 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US20100114018A1 (en) * 2007-11-14 2010-05-06 Boston Scientific Scimed, Inc. Balloon bifurcated lumen treatment
US7731741B2 (en) 2005-09-08 2010-06-08 Boston Scientific Scimed, Inc. Inflatable bifurcation stent
US7758634B2 (en) 2001-02-26 2010-07-20 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US7771462B1 (en) 1999-06-04 2010-08-10 Boston Scientific Scimed, Inc. Catheter with side sheath and methods
US20100241212A1 (en) * 2004-03-04 2010-09-23 Y Med, Inc. Vessel treatment devices
US7815675B2 (en) 1996-11-04 2010-10-19 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20100286720A1 (en) * 2004-03-04 2010-11-11 Y Med, Inc. Vessel treatment devices
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US7842082B2 (en) 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
US20110034949A1 (en) * 2006-05-11 2011-02-10 Y-Med, Inc. Systems and methods for treating a vessel using focused force
US20110077730A1 (en) * 2009-09-30 2011-03-31 Fenster Michael S Bifurcated balloon stent
US7922758B2 (en) 2006-06-23 2011-04-12 Boston Scientific Scimed, Inc. Nesting twisting hinge points in a bifurcated petal geometry
US7951191B2 (en) 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
US7951192B2 (en) 2001-09-24 2011-05-31 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US7959668B2 (en) 2007-01-16 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent
US7959669B2 (en) 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US20110190708A1 (en) * 2004-03-04 2011-08-04 YMED, Inc. Positioning device for ostial lesions
US8016878B2 (en) 2005-12-22 2011-09-13 Boston Scientific Scimed, Inc. Bifurcation stent pattern
US8206429B2 (en) 2006-11-02 2012-06-26 Boston Scientific Scimed, Inc. Adjustable bifurcation catheter incorporating electroactive polymer and methods of making and using the same
US8211167B2 (en) 1999-12-06 2012-07-03 Boston Scientific Scimed, Inc. Method of using a catheter with attached flexible side sheath
US8277501B2 (en) 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
US8377108B2 (en) 2008-06-02 2013-02-19 Boston Scientific Scimed, Inc. Staggered two balloon bifurcation catheter assembly and methods
US8486134B2 (en) 2007-08-01 2013-07-16 Boston Scientific Scimed, Inc. Bifurcation treatment system and methods
US8617231B2 (en) 2001-05-18 2013-12-31 Boston Scientific Scimed, Inc. Dual guidewire exchange catheter system
US8827954B2 (en) 2008-06-05 2014-09-09 Boston Scientific Scimed, Inc. Deflatable bifurcated device
US8932340B2 (en) 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
USRE48169E1 (en) 2007-06-25 2020-08-25 Glofish Llc Aquarium with adjustable lighting
EP3933046A1 (en) 2020-07-03 2022-01-05 Consejo Superior de Investigaciones Científicas (CSIC) Method for colorimetric detection of bacteria in food samples
US11744723B2 (en) 2004-03-04 2023-09-05 Y Med, Inc. Vessel treatment devices

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436104B2 (en) * 1996-01-26 2002-08-20 Cordis Corporation Bifurcated axially flexible stent
US6258116B1 (en) * 1996-01-26 2001-07-10 Cordis Corporation Bifurcated axially flexible stent
US6251133B1 (en) * 1996-05-03 2001-06-26 Medinol Ltd. Bifurcated stent with improved side branch aperture and method of making same
US7641685B2 (en) * 1996-05-03 2010-01-05 Medinol Ltd. System and method for delivering a bifurcated stent
US6440165B1 (en) * 1996-05-03 2002-08-27 Medinol, Ltd. Bifurcated stent with improved side branch aperture and method of making same
US6682536B2 (en) 2000-03-22 2004-01-27 Advanced Stent Technologies, Inc. Guidewire introducer sheath
JP4741728B2 (en) * 1998-06-04 2011-08-10 ニューヨーク・ユニバーシティ Intravascular thin film device and stroke treatment
JP2003525065A (en) * 1999-01-27 2003-08-26 ボストン サイエンティフィック リミテッド Bifurcation stent delivery system
US6361555B1 (en) * 1999-12-15 2002-03-26 Advanced Cardiovascular Systems, Inc. Stent and stent delivery assembly and method of use
EP1255506B1 (en) * 2000-02-18 2003-09-03 E.V.R. Endovascular Researches S.A. Endolumenal device for delivering and deploying an endolumenal expandable prosthesis
ITMI20020860A1 (en) * 2002-04-22 2003-10-22 E V R Endovascular Res Es S A ENDOLUMINAL DEVICE TO TRANSPORT AND DISPLAY AN EXPANDABLE ENDOLUMINAL PROSTHESIS
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
WO2002067815A1 (en) 2001-02-26 2002-09-06 Scimed Life Systems, Inc. Bifurcated stent
US7799064B2 (en) 2001-02-26 2010-09-21 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US6761733B2 (en) 2001-04-11 2004-07-13 Trivascular, Inc. Delivery system and method for bifurcated endovascular graft
US6733521B2 (en) 2001-04-11 2004-05-11 Trivascular, Inc. Delivery system and method for endovascular graft
ES2319621T3 (en) 2001-08-23 2009-05-11 Darrell C. Gumm ROTARY SYSTEM OF IMPLANT OF ENDOVASCULAR PROTESIS FOR ACCSO OF SIDE BRANCH AND PROTECTION.
US20100016943A1 (en) 2001-12-20 2010-01-21 Trivascular2, Inc. Method of delivering advanced endovascular graft
US6916409B1 (en) 2002-12-31 2005-07-12 Advanced Cardiovascular Systems, Inc. Apparatus and process for electrolytic removal of material from a medical device
US7918884B2 (en) * 2003-02-25 2011-04-05 Cordis Corporation Stent for treatment of bifurcated lesions
US7942920B2 (en) * 2003-02-25 2011-05-17 Cordis Corporation Stent with nested fingers for enhanced vessel coverage
US20050131524A1 (en) * 2003-02-25 2005-06-16 Majercak David C. Method for treating a bifurcated vessel
US7367989B2 (en) * 2003-02-27 2008-05-06 Scimed Life Systems, Inc. Rotating balloon expandable sheath bifurcation delivery
US8109987B2 (en) 2003-04-14 2012-02-07 Tryton Medical, Inc. Method of treating a lumenal bifurcation
US7731747B2 (en) 2003-04-14 2010-06-08 Tryton Medical, Inc. Vascular bifurcation prosthesis with multiple thin fronds
US8083791B2 (en) 2003-04-14 2011-12-27 Tryton Medical, Inc. Method of treating a lumenal bifurcation
US7972372B2 (en) 2003-04-14 2011-07-05 Tryton Medical, Inc. Kit for treating vascular bifurcations
US7717953B2 (en) 2004-10-13 2010-05-18 Tryton Medical, Inc. Delivery system for placement of prosthesis at luminal OS
US7758630B2 (en) 2003-04-14 2010-07-20 Tryton Medical, Inc. Helical ostium support for treating vascular bifurcations
US8784472B2 (en) * 2003-08-15 2014-07-22 Boston Scientific Scimed, Inc. Clutch driven stent delivery system
US20050131526A1 (en) * 2003-12-10 2005-06-16 Shing-Chiu Wong Stent and balloon system for bifurcated vessels and lesions
US7686841B2 (en) 2003-12-29 2010-03-30 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery system
US7922753B2 (en) 2004-01-13 2011-04-12 Boston Scientific Scimed, Inc. Bifurcated stent delivery system
US8012192B2 (en) 2004-02-18 2011-09-06 Boston Scientific Scimed, Inc. Multi-stent delivery system
US7744619B2 (en) 2004-02-24 2010-06-29 Boston Scientific Scimed, Inc. Rotatable catheter assembly
US7922740B2 (en) 2004-02-24 2011-04-12 Boston Scientific Scimed, Inc. Rotatable catheter assembly
AU2005202182A1 (en) * 2004-06-08 2005-12-22 Cordis Corporation Method for treating a bifurcated vessel
WO2006024488A2 (en) 2004-08-30 2006-03-09 Interstitial Therapeutics Medical stent provided with inhibitors of atp synthesis
US8608789B2 (en) * 2005-05-24 2013-12-17 Trireme Medical, Inc. Delivery system for bifurcation stents
US20090259288A1 (en) * 2005-05-27 2009-10-15 Bandula Wijay Catheter device for delivery of stents to bifurcated arteries
US20070208415A1 (en) * 2006-03-06 2007-09-06 Kevin Grotheim Bifurcated stent with controlled drug delivery
US8167929B2 (en) * 2006-03-09 2012-05-01 Abbott Laboratories System and method for delivering a stent to a bifurcated vessel
US8246670B2 (en) * 2006-08-23 2012-08-21 Abbott Cardiovascular Systems Inc. Catheter system and method for delivering medical devices
US8608790B2 (en) * 2006-10-06 2013-12-17 Boston Scientific Scimed, Inc. Bifurcation catheter and method
KR100847123B1 (en) * 2006-11-22 2008-07-18 주식회사 스텐다드싸이텍 Stent
US8066755B2 (en) 2007-09-26 2011-11-29 Trivascular, Inc. System and method of pivoted stent deployment
US8663309B2 (en) 2007-09-26 2014-03-04 Trivascular, Inc. Asymmetric stent apparatus and method
US8226701B2 (en) 2007-09-26 2012-07-24 Trivascular, Inc. Stent and delivery system for deployment thereof
WO2009046372A2 (en) 2007-10-04 2009-04-09 Trivascular2, Inc. Modular vascular graft for low profile percutaneous delivery
US8328861B2 (en) 2007-11-16 2012-12-11 Trivascular, Inc. Delivery system and method for bifurcated graft
US8083789B2 (en) 2007-11-16 2011-12-27 Trivascular, Inc. Securement assembly and method for expandable endovascular device
DE102007060497A1 (en) * 2007-12-06 2009-06-10 Joline Gmbh & Co. Kg Implantable vascular support
US20090287148A1 (en) * 2008-05-15 2009-11-19 Martin Daryl L Joined Inflation Portions for Bifurcation Catheter
US8333003B2 (en) 2008-05-19 2012-12-18 Boston Scientific Scimed, Inc. Bifurcation stent crimping systems and methods
US8133199B2 (en) 2008-08-27 2012-03-13 Boston Scientific Scimed, Inc. Electroactive polymer activation system for a medical device
US20100318170A1 (en) * 2009-06-15 2010-12-16 Richard Newhauser Proximal catheter flap for managing wire twist
US8382818B2 (en) 2009-07-02 2013-02-26 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
US9402754B2 (en) 2010-05-18 2016-08-02 Abbott Cardiovascular Systems, Inc. Expandable endoprostheses, systems, and methods for treating a bifurcated lumen
US9707108B2 (en) 2010-11-24 2017-07-18 Tryton Medical, Inc. Support for treating vascular bifurcations
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9498363B2 (en) 2012-04-06 2016-11-22 Trivascular, Inc. Delivery catheter for endovascular device
WO2013162724A1 (en) 2012-04-26 2013-10-31 Tryton Medical, Inc. Support for treating vascular bifurcations
CN107787211B (en) 2015-05-27 2020-12-08 特里瓦斯库拉尔公司 Balloon assisted endoluminal prosthesis deployment
US10179057B2 (en) * 2015-05-28 2019-01-15 George Kramer Tracheobronchial Y-stents, delivery catheters and delivery apparatus, and methods for delivering bronchial Y-stents
EP3381416B1 (en) 2017-03-29 2020-07-22 Cook Medical Technologies LLC Prosthesis with flexible stent

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3392722A (en) * 1965-07-29 1968-07-16 Roger L. Jorgensen Post-operative surgical valve
US3721233A (en) * 1970-10-30 1973-03-20 W Montgomery T-shaped tracheal stent
US4795465A (en) * 1987-05-14 1989-01-03 Hood Laboratories Tracheobronchial stent
US5104404A (en) * 1989-10-02 1992-04-14 Medtronic, Inc. Articulated stent
US5653743A (en) * 1994-09-09 1997-08-05 Martin; Eric C. Hypogastric artery bifurcation graft and method of implantation
US5709713A (en) * 1995-03-31 1998-01-20 Cardiovascular Concepts, Inc. Radially expansible vascular prosthesis having reversible and other locking structures
US5776161A (en) * 1995-10-16 1998-07-07 Instent, Inc. Medical stents, apparatus and method for making same
US5785679A (en) * 1995-07-19 1998-07-28 Endotex Interventional Systems, Inc. Methods and apparatus for treating aneurysms and arterio-venous fistulas
US5851228A (en) * 1995-06-01 1998-12-22 Meadox Medicals, Inc. Implantable intraluminal prosthesis
US6017363A (en) * 1997-09-22 2000-01-25 Cordis Corporation Bifurcated axially flexible stent
US6033434A (en) * 1995-06-08 2000-03-07 Ave Galway Limited Bifurcated endovascular stent and methods for forming and placing
US6436104B2 (en) * 1996-01-26 2002-08-20 Cordis Corporation Bifurcated axially flexible stent
US6835203B1 (en) * 1996-11-04 2004-12-28 Advanced Stent Technologies, Inc. Extendible stent apparatus

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156612A (en) 1988-10-04 1992-10-20 Cordis Corporation Balloons for medical devices and fabrication thereof
US5108415A (en) 1988-10-04 1992-04-28 Cordis Corporation Balloons for medical devices and fabrication thereof
US5304197A (en) 1988-10-04 1994-04-19 Cordis Corporation Balloons for medical devices and fabrication thereof
US4994071A (en) 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
EP1477132A3 (en) 1994-10-17 2009-09-09 Kabushikikaisha Igaki Iryo Sekkei Drug-releasing stent
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
NL1000180C1 (en) 1995-04-20 1996-10-22 Laurens Sibinga Mulder Endovascular bifurcation prosthesis for used in treating of aorta bifurcate
FR2733682B1 (en) 1995-05-04 1997-10-31 Dibie Alain ENDOPROSTHESIS FOR THE TREATMENT OF STENOSIS ON BIFURCATIONS OF BLOOD VESSELS AND LAYING EQUIPMENT THEREFOR
US5591228A (en) 1995-05-09 1997-01-07 Edoga; John K. Methods for treating abdominal aortic aneurysms
US5669924A (en) 1995-10-26 1997-09-23 Shaknovich; Alexander Y-shuttle stent assembly for bifurcating vessels and method of using the same
FR2740346A1 (en) 1995-10-30 1997-04-30 Debiotech Sa ANGIOPLASTY DEVICE FOR ARTERIAL BIFURCATION
US5713854A (en) * 1995-11-01 1998-02-03 Cordis Corporation Method and apparatus for dilatation catheterization
US5690642A (en) * 1996-01-18 1997-11-25 Cook Incorporated Rapid exchange stent delivery balloon catheter
US5895406A (en) 1996-01-26 1999-04-20 Cordis Corporation Axially flexible stent
US6258116B1 (en) * 1996-01-26 2001-07-10 Cordis Corporation Bifurcated axially flexible stent
WO1997045073A1 (en) * 1996-05-31 1997-12-04 Bard Galway Limited Bifurcated endovascular stents and method and apparatus for their placement
US5728150A (en) 1996-07-29 1998-03-17 Cardiovascular Dynamics, Inc. Expandable microporous prosthesis
US5749825A (en) * 1996-09-18 1998-05-12 Isostent, Inc. Means method for treatment of stenosed arterial bifurcations
US6083232A (en) 1996-09-27 2000-07-04 Advanced Cardivascular Systems, Inc. Vibrating stent for opening calcified lesions
AU4896797A (en) * 1996-11-04 1998-05-29 Davidson, Charles Extendible stent apparatus and method for deploying the same
US5720735A (en) * 1997-02-12 1998-02-24 Dorros; Gerald Bifurcated endovascular catheter
EP1011528A1 (en) 1997-02-25 2000-06-28 SciMed Life Systems, Inc. Stents and stent delivery and dilatation system for bifurcation lesions
US5830229A (en) 1997-03-07 1998-11-03 Micro Therapeutics Inc. Hoop stent
US5895495A (en) 1997-03-13 1999-04-20 International Business Machines Corporation Demand-based larx-reserve protocol for SMP system buses
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
DE29708803U1 (en) * 1997-05-17 1997-07-31 Jomed Implantate Gmbh Radially expandable stent for implantation in a body vessel in the area of a vascular branch
US6165195A (en) * 1997-08-13 2000-12-26 Advanced Cardiovascylar Systems, Inc. Stent and catheter assembly and method for treating bifurcations
WO1999008744A1 (en) 1997-08-15 1999-02-25 Alexander Shaknovich A distal protection/wash-out method for treating vessels
US6015432A (en) 1998-02-25 2000-01-18 Cordis Corporation Wire reinforced vascular prosthesis

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3392722A (en) * 1965-07-29 1968-07-16 Roger L. Jorgensen Post-operative surgical valve
US3721233A (en) * 1970-10-30 1973-03-20 W Montgomery T-shaped tracheal stent
US4795465A (en) * 1987-05-14 1989-01-03 Hood Laboratories Tracheobronchial stent
US5104404A (en) * 1989-10-02 1992-04-14 Medtronic, Inc. Articulated stent
US5653743A (en) * 1994-09-09 1997-08-05 Martin; Eric C. Hypogastric artery bifurcation graft and method of implantation
US5755772A (en) * 1995-03-31 1998-05-26 Medtronic, Inc. Radially expansible vascular prosthesis having reversible and other locking structures
US5709713A (en) * 1995-03-31 1998-01-20 Cardiovascular Concepts, Inc. Radially expansible vascular prosthesis having reversible and other locking structures
US5851228A (en) * 1995-06-01 1998-12-22 Meadox Medicals, Inc. Implantable intraluminal prosthesis
US6033434A (en) * 1995-06-08 2000-03-07 Ave Galway Limited Bifurcated endovascular stent and methods for forming and placing
US5785679A (en) * 1995-07-19 1998-07-28 Endotex Interventional Systems, Inc. Methods and apparatus for treating aneurysms and arterio-venous fistulas
US5776161A (en) * 1995-10-16 1998-07-07 Instent, Inc. Medical stents, apparatus and method for making same
US6436104B2 (en) * 1996-01-26 2002-08-20 Cordis Corporation Bifurcated axially flexible stent
US6835203B1 (en) * 1996-11-04 2004-12-28 Advanced Stent Technologies, Inc. Extendible stent apparatus
US6017363A (en) * 1997-09-22 2000-01-25 Cordis Corporation Bifurcated axially flexible stent

Cited By (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678142B2 (en) 1996-11-04 2010-03-16 Boston Scientific Scimed, Inc. Extendible stent apparatus
US20040015227A1 (en) * 1996-11-04 2004-01-22 Gil Vardi Extendible stent apparatus
US7766955B2 (en) 1996-11-04 2010-08-03 Boston Scientific Scimed, Inc. Extendible stent apparatus
US8771342B2 (en) 1996-11-04 2014-07-08 Boston Scientific Scimed, Inc. Methods for deploying stents in bifurcations
US20040138737A1 (en) * 1996-11-04 2004-07-15 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US20090326634A1 (en) * 1996-11-04 2009-12-31 Boston Scientific Scimed, Inc. Methods for deploying stents in bifurcations
US6835203B1 (en) 1996-11-04 2004-12-28 Advanced Stent Technologies, Inc. Extendible stent apparatus
US20050010278A1 (en) * 1996-11-04 2005-01-13 Advanced Stent Technologies, Inc. Extendible stent apparatus
US7850725B2 (en) 1996-11-04 2010-12-14 Boston Scientific Scimed, Inc. Extendible stent apparatus
US9561126B2 (en) 1996-11-04 2017-02-07 Boston Scientific Scimed, Inc. Catheter with attached flexible side sheath
US20020116047A1 (en) * 1996-11-04 2002-08-22 Vardi Gil M. Extendible stent apparatus and method for deploying the same
US7815675B2 (en) 1996-11-04 2010-10-19 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20060085061A1 (en) * 1996-11-04 2006-04-20 Vardi Gil M Extendible stent apparatus and method for deploying the same
US6706062B2 (en) 1998-01-14 2004-03-16 Advanced Stent Technologies, Inc. Extendible stent apparatus
US8241349B2 (en) 1998-01-14 2012-08-14 Boston Scientific Scimed, Inc. Extendible stent apparatus
US7892279B2 (en) 1998-01-14 2011-02-22 Boston Scientific Scimed, Inc. Extendible stent apparatus
US20070118205A1 (en) * 1999-01-13 2007-05-24 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US8257425B2 (en) 1999-01-13 2012-09-04 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US7771462B1 (en) 1999-06-04 2010-08-10 Boston Scientific Scimed, Inc. Catheter with side sheath and methods
US20080255581A1 (en) * 1999-06-04 2008-10-16 Boston Scientific Scimed, Inc. Short sleeve stent delivery catheter and methods
US20030195606A1 (en) * 1999-09-23 2003-10-16 Advanced Stent Technologies, Inc., A Delaware Corporation Bifurcation stent system and method
US20040148006A1 (en) * 1999-09-23 2004-07-29 Davidson Charles J Stent range transducers and methods of use
US8211167B2 (en) 1999-12-06 2012-07-03 Boston Scientific Scimed, Inc. Method of using a catheter with attached flexible side sheath
US7758634B2 (en) 2001-02-26 2010-07-20 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US8617231B2 (en) 2001-05-18 2013-12-31 Boston Scientific Scimed, Inc. Dual guidewire exchange catheter system
US7951192B2 (en) 2001-09-24 2011-05-31 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US8425590B2 (en) 2001-09-24 2013-04-23 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20050065596A1 (en) * 2002-07-24 2005-03-24 Xufan Tseng Stents capable of controllably releasing histone deacetylase inhibitors
EP1629861A1 (en) * 2003-06-02 2006-03-01 Nipro Corporation Soft stent with excellent follow-up capability to blood vessel
EP1629861A4 (en) * 2003-06-02 2011-05-11 Nipro Corp Soft stent with excellent follow-up capability to blood vessel
US7655030B2 (en) 2003-07-18 2010-02-02 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US8771334B2 (en) 2003-07-18 2014-07-08 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US8298280B2 (en) 2003-08-21 2012-10-30 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20050102023A1 (en) * 2003-08-21 2005-05-12 Amnon Yadin Stent with protruding branch portion for bifurcated vessels
US20080109060A1 (en) * 2003-11-12 2008-05-08 Advanced Stent Technologies, Inc. Catheter balloon systems and methods
US8702779B2 (en) 2003-11-12 2014-04-22 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US20050102019A1 (en) * 2003-11-12 2005-05-12 Advanced Stent Technologies, Inc. Catheter balloon systems and methods
US9050437B2 (en) 2004-03-04 2015-06-09 YMED, Inc. Positioning device for ostial lesions
US20110190708A1 (en) * 2004-03-04 2011-08-04 YMED, Inc. Positioning device for ostial lesions
US9504473B2 (en) 2004-03-04 2016-11-29 Y Med Inc. Vessel treatment devices
US20100241212A1 (en) * 2004-03-04 2010-09-23 Y Med, Inc. Vessel treatment devices
US11744723B2 (en) 2004-03-04 2023-09-05 Y Med, Inc. Vessel treatment devices
US20100286720A1 (en) * 2004-03-04 2010-11-11 Y Med, Inc. Vessel treatment devices
US8007528B2 (en) 2004-03-17 2011-08-30 Boston Scientific Scimed, Inc. Bifurcated stent
US20070225796A1 (en) * 2004-03-17 2007-09-27 Boston Scientific Scimed, Inc. Bifurcated stent
US20070142902A1 (en) * 2004-12-14 2007-06-21 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US9427340B2 (en) 2004-12-14 2016-08-30 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US8480728B2 (en) 2005-05-26 2013-07-09 Boston Scientific Scimed, Inc. Stent side branch deployment initiation geometry
US20060271161A1 (en) * 2005-05-26 2006-11-30 Boston Scientific Scimed, Inc. Selective treatment of stent side branch petals
US20060271160A1 (en) * 2005-05-26 2006-11-30 Boston Scientific Scimed, Inc. Stent side branch deployment initiation geometry
US8317855B2 (en) 2005-05-26 2012-11-27 Boston Scientific Scimed, Inc. Crimpable and expandable side branch cell
US20060271159A1 (en) * 2005-05-26 2006-11-30 Boston Scientific Scimed, Inc. Crimpable and expandable side branch cell
US20070016241A1 (en) * 2005-06-24 2007-01-18 Abbott Laboratories Balloon catheter
US7578831B2 (en) 2005-06-24 2009-08-25 Abbott Laboratories Balloon catheter
WO2007002423A3 (en) * 2005-06-24 2007-07-12 Abbott Lab Balloon catheter
WO2007002423A2 (en) * 2005-06-24 2007-01-04 Abbott Laboratories Balloon catheter
US20070055351A1 (en) * 2005-09-08 2007-03-08 Boston Scientific Scimed, Inc. Crown stent assembly
US8038706B2 (en) 2005-09-08 2011-10-18 Boston Scientific Scimed, Inc. Crown stent assembly
US8043366B2 (en) 2005-09-08 2011-10-25 Boston Scientific Scimed, Inc. Overlapping stent
US7731741B2 (en) 2005-09-08 2010-06-08 Boston Scientific Scimed, Inc. Inflatable bifurcation stent
US20070055362A1 (en) * 2005-09-08 2007-03-08 Boston Scientific Scimed, Inc. Overlapping stent
US7842081B2 (en) 2005-11-14 2010-11-30 Boston Scientific Scimed, Inc. Stent with spiral side-branch
US20070112418A1 (en) * 2005-11-14 2007-05-17 Boston Scientific Scimed, Inc. Stent with spiral side-branch support designs
WO2007067642A1 (en) * 2005-12-05 2007-06-14 Abbott Laboratories Catheter balloon device with internal guidewire lumen and method of formation
US20070129750A1 (en) * 2005-12-05 2007-06-07 Abbott Laboratories Catheter balloon device with internal guidewire lumen and method of formation
US8343211B2 (en) 2005-12-14 2013-01-01 Boston Scientific Scimed, Inc. Connectors for bifurcated stent
US8435284B2 (en) 2005-12-14 2013-05-07 Boston Scientific Scimed, Inc. Telescoping bifurcated stent
US20070135904A1 (en) * 2005-12-14 2007-06-14 Tracee Eidenschink Telescoping bifurcated stent
US20070135903A1 (en) * 2005-12-14 2007-06-14 Daniel Gregorich Connectors for bifurcated stent
US8016878B2 (en) 2005-12-22 2011-09-13 Boston Scientific Scimed, Inc. Bifurcation stent pattern
US8821561B2 (en) 2006-02-22 2014-09-02 Boston Scientific Scimed, Inc. Marker arrangement for bifurcation catheter
US20070203562A1 (en) * 2006-02-22 2007-08-30 Andrzej Malewicz Marker arrangement for bifurcation catheter
US7833264B2 (en) 2006-03-06 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent
US20070208411A1 (en) * 2006-03-06 2007-09-06 Boston Scientific Scimed, Inc. Bifurcated stent with surface area gradient
US20070208419A1 (en) * 2006-03-06 2007-09-06 Boston Scientific Scimed, Inc. Bifurcation stent with uniform side branch projection
US20070208418A1 (en) * 2006-03-06 2007-09-06 Boston Scientific Scimed, Inc. Bifurcated stent
US8298278B2 (en) 2006-03-07 2012-10-30 Boston Scientific Scimed, Inc. Bifurcated stent with improvement securement
US20070213811A1 (en) * 2006-03-07 2007-09-13 Boston Scientific Scimed, Inc. Bifurcated stent with improvement securement
US20070233233A1 (en) * 2006-03-31 2007-10-04 Boston Scientific Scimed, Inc Tethered expansion columns for controlled stent expansion
US8070729B2 (en) 2006-05-11 2011-12-06 YMED, Inc. Systems and methods for treating a vessel using focused force
US20090275920A1 (en) * 2006-05-11 2009-11-05 Solar Ronald J Systems and methods for treating a vessel using focused force
US8486025B2 (en) 2006-05-11 2013-07-16 Ronald J. Solar Systems and methods for treating a vessel using focused force
US20110118774A1 (en) * 2006-05-11 2011-05-19 YMED, Inc. Systems and methods for treating a vessel using focused force
US20110034949A1 (en) * 2006-05-11 2011-02-10 Y-Med, Inc. Systems and methods for treating a vessel using focused force
US8262621B2 (en) 2006-05-11 2012-09-11 YMED, Inc. Systems and methods for treating a vessel using focused force
US20090292241A1 (en) * 2006-06-23 2009-11-26 Abbott Laboratories Balloon catheter
US7922758B2 (en) 2006-06-23 2011-04-12 Boston Scientific Scimed, Inc. Nesting twisting hinge points in a bifurcated petal geometry
US9492297B2 (en) 2006-09-12 2016-11-15 Boston Scientific Scimed, Inc. Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US8216267B2 (en) 2006-09-12 2012-07-10 Boston Scientific Scimed, Inc. Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US20080065188A1 (en) * 2006-09-12 2008-03-13 Boston Scientific Scimed, Inc. Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US7951191B2 (en) 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
US8206429B2 (en) 2006-11-02 2012-06-26 Boston Scientific Scimed, Inc. Adjustable bifurcation catheter incorporating electroactive polymer and methods of making and using the same
US8556955B2 (en) 2006-11-02 2013-10-15 Boston Scientific Scimed, Inc. Adjustable bifurcation catheter incorporating electroactive polymer and methods of makings and using the same
US7842082B2 (en) 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
US7959668B2 (en) 2007-01-16 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent
US20080243232A1 (en) * 2007-03-28 2008-10-02 Boston Scientific Scimed, Inc. Bifurcation stent and balloon assemblies
US8118861B2 (en) 2007-03-28 2012-02-21 Boston Scientific Scimed, Inc. Bifurcation stent and balloon assemblies
US20080243221A1 (en) * 2007-03-30 2008-10-02 Boston Scientific Scimed, Inc. Balloon fold design for deployment of bifurcated stent petal architecture
US8647376B2 (en) 2007-03-30 2014-02-11 Boston Scientific Scimed, Inc. Balloon fold design for deployment of bifurcated stent petal architecture
USRE48169E1 (en) 2007-06-25 2020-08-25 Glofish Llc Aquarium with adjustable lighting
USRE49345E1 (en) 2007-06-25 2022-12-27 GloFish, LLC Aquarium with adjustable lighting
US8486134B2 (en) 2007-08-01 2013-07-16 Boston Scientific Scimed, Inc. Bifurcation treatment system and methods
US7959669B2 (en) 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US20100114018A1 (en) * 2007-11-14 2010-05-06 Boston Scientific Scimed, Inc. Balloon bifurcated lumen treatment
US8936567B2 (en) 2007-11-14 2015-01-20 Boston Scientific Scimed, Inc. Balloon bifurcated lumen treatment
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8277501B2 (en) 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
US8747456B2 (en) 2007-12-31 2014-06-10 Boston Scientific Scimed, Inc. Bifurcation stent delivery system and methods
US20090171430A1 (en) * 2007-12-31 2009-07-02 Boston Scientific Scimed, Inc. Bifurcation stent delivery system and methods
US8932340B2 (en) 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US8377108B2 (en) 2008-06-02 2013-02-19 Boston Scientific Scimed, Inc. Staggered two balloon bifurcation catheter assembly and methods
US8827954B2 (en) 2008-06-05 2014-09-09 Boston Scientific Scimed, Inc. Deflatable bifurcated device
US20110077730A1 (en) * 2009-09-30 2011-03-31 Fenster Michael S Bifurcated balloon stent
EP3933046A1 (en) 2020-07-03 2022-01-05 Consejo Superior de Investigaciones Científicas (CSIC) Method for colorimetric detection of bacteria in food samples
WO2022003201A1 (en) 2020-07-03 2022-01-06 Consejo Superior De Investigaciones Cientificas Method for colorimetric detection of bacteria in food samples

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AU1943000A (en) 2000-08-31
US6436104B2 (en) 2002-08-20
US20010004706A1 (en) 2001-06-21
DE60023769T2 (en) 2006-06-08
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JP2000262633A (en) 2000-09-26
DE60023769D1 (en) 2005-12-15

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