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Publication numberUS20020156516 A1
Publication typeApplication
Application numberUS 09/919,226
Publication date24 Oct 2002
Filing date31 Jul 2001
Priority date4 Nov 1996
Also published asDE69736676D1, DE69736676T2, EP0944366A1, EP0944366A4, EP0944366B1, EP1723931A2, EP1723931A3, EP1723931B1, US6210429, US6962602, US20010037137, US20020116047, US20060085061, US20090132028, WO1998019628A1, WO1999036002A1
Publication number09919226, 919226, US 2002/0156516 A1, US 2002/156516 A1, US 20020156516 A1, US 20020156516A1, US 2002156516 A1, US 2002156516A1, US-A1-20020156516, US-A1-2002156516, US2002/0156516A1, US2002/156516A1, US20020156516 A1, US20020156516A1, US2002156516 A1, US2002156516A1
InventorsGil Vardi, Charles Davidson
Original AssigneeAdvanced Stent Technologies, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method for employing an extendible stent apparatus
US 20020156516 A1
Abstract
An imageable extendable stent apparatus for insertion into a bifurcating vessel or a vessel opening. The stent apparatus comprises a main stent and a flared stent, which may used individually or in combination with each other. The flared stent may be interlocked with the main stent to provide stent coverage over the entire region of a bifurcation. The main stent of the apparatus may be deployed at the bifurcation point of a vessel, allowing unimpeded future access to the side branch of the bifurcated vessel. The flared stent may be employed at vessel openings. Also disclosed and claimed are methods for implanting the extendable stent apparatus into the bifurcation point or the ostium of a subject vessel.
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Claims(22)
We claim:
1. An extending double-stent apparatus for placement in a bifurcating vessel comprising a first generally cylindrical stent having sides extending between first and second opposing ends and at least one opening being defined in a side; and a second generally cylindrical stent adapted to extend through one of said side openings of said first stent, said first and second stents each being constructed from a material which allows said stents to be expanded to conform to the shape of the subject vessel.
2. The stent apparatus of claim 1 wherein said second cylindrical stent additionally comprises a proximal end and an opposing distal end, wherein the proximal end additionally comprises a flared portion, which flared portion is in contact with the edges of said first stent-side opening.
3. The stent apparatus of claim 1 wherein the stent apparatus is comprised of a biologically acceptable material.
4. The stent apparatus of claim 1 wherein the stents comprise a self-expanding material.
5. The stent apparatus of claim 1 wherein the stents comprise a balloon-expandable material.
6. The stent apparatus of claim 1 wherein at least a portion of the stents are imageable during and after insertion.
7. A generally cylindrical stent apparatus comprising a proximal end and a distal end, wherein the proximal end further comprises a flared portion for anchoring said stent apparatus into place within a vessel.
8. The stent apparatus of claim 7 wherein the flared portion is expandable from a compressed position to a configuration extending radially, at least in part, to the longitudinal axis of the stent apparatus.
9. The stent apparatus of claim 7 wherein the stent apparatus is comprised of a biologically acceptable material.
10. The stent apparatus of claim 7 wherein the stent comprises a self-expanding material.
11. The stent apparatus of claim 7 wherein the stents comprise a balloon-expandable material.
12. The stent apparatus of claim 7 wherein at least a portion of the stent is imageable during and after insertion.
13. A generally cylindrical stent apparatus having sides extending between first and second opposing ends and at least one opening being defined in a stent side.
14. The stent apparatus of claim 13 wherein the stent apparatus is comprised of a biologically acceptable material.
15. The stent apparatus of claim 13 wherein the stent comprises a self-expanding material.
16. The stent apparatus of claim 13 wherein at least a portion of the stents are imageable during and after insertion.
17. A method for deploying a stent apparatus into a bifurcated vessel comprising the steps of
routing a first guidewire into the main vessel of a subject bifurcating vessel and extending the guidewire beyond the bifurcation point;
inserting a first generally cylindrical stent apparatus comprising at least one side opening into an area of bifurcation of the main vessel;
aligning a side opening of the first stent apparatus with the bifurcation point of the bifurcated vessel by inserting a second guidewire and a stabilizing catheter into the first stent apparatus and into a subject branch vessel by passing the second guidewire and the stabilizing catheter through a side opening of the first stent apparatus and into the subject branch vessel; and
expanding the first cylindrical stent apparatus into contact with the walls of the main vessel.
18. The method of claim 17 further comprising
inserting along the second guidewire and into the stabilizing catheter of the branch vessel a second generally cylindrical stent apparatus, comprising a distal end and an opposed proximal end and further comprising a flared portion at the proximal end, positioned so that the flared portion is within a lumen of a subject branch vessel and contacts at least part of the edge of a side opening of the first stent apparatus;
withdrawing the stabilizing catheter from the subject vessel; and
expanding the second cylindrical stent apparatus at least into contact with the walls of the subject branch vessel.
19. The method of claim 17 wherein the step of expanding the first cylindrical stent apparatus is performed by balloon catheterization.
20. The method of claim 18 wherein the steps of expanding the first and second cylindrical stent apparatuses is performed by balloon catheterization.
21. A method for deploying a flared stent apparatus into the ostium of a vessel comprising:
inserting a guidewire through the ostium of a vessel and into the vessel,
inserting around the guidewire a generally cylindrical flared stent apparatus, the flared stent apparatus comprising a distal end and an opposed proximal end and further comprising a flared portion at the proximal end;
positioning the flared portion so that the flared portion is within the ostium of the vessel and contacts at least part of the ostium of said vessel;
dilating the flared stent apparatus at least into contact with the walls of the subject vessel; and
removing the guidewire from the subject.
22. The method of claim 21 further comprising the step of dilating the flared stent apparatus by balloon catheterization.
Description
    BACKGROUND
  • [0001]
    A type of endoprosthesis device, commonly referred to as a stent, is placed or implanted within a vein, artery or other tubular body organ for treating occlusions, stenoses, or aneurysms of the vessel. These stent devices are implanted within tubular vessels to reinforce collapsing, partially occluded, weakened, or abnormally dilated segments of the vessel wall. Stents have been used to treat dissections in blood vessel walls caused by balloon angioplasty of the coronary arteries as well as peripheral arteries and to improve angioplasty results by preventing elastic recoil and remodeling of the vessel wall.
  • [0002]
    Stents also have been successfully implanted in the urinary tract, the bile duct, the esophagus and the tracheo-bronchial tree to reinforce those body organs. Two randomized multicenter trials have recently shown a lower restenosis rate in stent treated coronary arteries compared with balloon angioplasty alone (Serruys P W et. al. New England Journal of Medicine 331: 489495, 1994, Fischman D L et. al. New England Journal of Medicine 331: 496-501, 1994).
  • [0003]
    One of the drawbacks of conventional stents is that they are produced in a straight tubular configuration. The use of such stents to treat disease at or near a branch or bifurcation of a vessel runs the risk of compromising the degree of patency of the primary vessel and/or its branches or bifurcation and also limits the ability to insert a second stent into the side branch if the angioplasty result is suboptimal. This may occur as a result of several mechanisms such as displacing diseased tissue or plaque shifting, vessel spasm, dissection with or without intimal flaps, thrombosis, and embolism.
  • [0004]
    The risk of branch compromise is increased in two anatomical situations. First the side branch can be compromised when there is a stenosis in the origin of the side branch. Second, when there is an eccentric lesion at the bifurcation site, asymmetric expansion can cause either plaque shifting or dissection at the side branch origin. There are reports of attempting to solve this problem by inserting a balloon into the side branch through the stent struts; however, this technique carries the risk of balloon entrapment and other major complications (Nakamura, S. et al., Catheterization and Cardiovascular Diagnosis 34: 353-361-(1995)). Moreover, adequate dilatation of the side branch is limited by elastic recoil of the origin of the side branch. In addition, the stent may pose a limitation to blood flow and may limit access to the side branch. The term “stent jail” is often used to describe this concept. In this regard, the tubular slotted hinged design of the Palmaz-Schatz intracoronary stent, in particular, is felt to be unfavorable for lesions with a large side branch and it is believed to pose a higher risk of side branch vessel entrapment where the stent prevents or limits access to the side branch. Id.
  • [0005]
    One common procedure for implanting the endoprosthesis or stent is to first open the region of the vessel with a balloon catheter and then place the stent in a position that bridges the treated portion of the vessel in order to prevent-elastic recoil and restenosis of that segment. The angioplasty of the bifurcation lesion has traditionally been performed using the kissing balloon technique where two guidewires and two balloons are inserted, one into the main branch and the other into the side branch. Stent placement in this situation will require the removal of the guidewire from the side branch and reinsertion of the guidewire via the stent struts and insertion of a balloon through the struts of the stent. The removal of the guidewire poses the risk of occlusion of the side branch during the deployment of the stent in the main branch.
  • [0006]
    Prior art patents refer to the construction and design of both the stent as well as the apparatus for positioning the stent within the vessel. One representative patent to Chaudhury, U.S. Pat. No. 4,140,126, discloses a technique for positioning an elongated cylindrical stent at a region of an aneurysm to avoid catastrophic failure of the blood vessel wall. The '126 patent discloses a cylinder that expands to its implanted configuration after insertion with the aid of a catheter. Dotter, U.S. Pat. No. 4,503,569, discloses a spring stent which expands to an implanted configuration with a change in temperature. The spring stent is -implanted in a coiled orientation and is then heated to cause the spring to expand. Palmaz, U.S. Pat. No. 4,733,665, discloses a umber of stent configurations for implantation with the aid of a catheter. The catheter includes mechanism for mounting and-retaining the vascular prosthesis or stent, preferably on an inflatable portion of the catheter. The stents are implanted while imaged on a monitor. Once the stent is properly positioned, the catheter is expanded and the stent separated from the catheter body. The catheter can then be withdrawn from the subject, leaving the stent in place within the blood vessel. Palmaz, U.S. Pat. No. 4,739,762, discloses an expandable intraluminal graft. Schjeldahl et. al., U.S. Pat. No. 4,413,989, discloses a variety of balloon catheter constructions. Maginot, U.S. Pat. No. 5,456,712 and Maginot, U.S. Pat No. 5,304,220 disclose graft and stent assembly and method of implantation where a stent is used to reinforce a graft surgically inserted into a blood vessel in order to bypass an occlusion. However, none of these patents relate to the treatment of bifurcation lesions, or disclose a bifurcating stent apparatus and method for deploying the same.
  • [0007]
    Taheri, U.S. Pat. No. 4,872,874, Piplani et. al., U.S. Pat. No. 5,489,295, and Marin et al., U.S. Pat. No. 5,507,769, disclose bifurcating graft material which may be implanted with stents. However, there is no mention of bifurcation of the stent, and the stent is used only to anchor the graft into the vessel wall. It does not reinforce the vessel wall, nor does it prevent restenosis after angioplasty.
  • [0008]
    MacGregor, U.S. Pat. No. 4,994,071, discloses a hinged bifurcating stent. In the 071' patent, in contrast to the present invention, there is a main stent with two additional stents attached at one end, creating a single unit with a bifurcation. The two additional stents are permanently attached and cannot be removed from the main stent. Thus, this invention may not be used in non-bifurcation vessels. In addition, studies with hinge-containing stents have shown that there is a high incidence of restenosis (tissue growth) at the hinge point that may cause narrowing or total occlusion of the vessel and thus compromise blood flow. Furthermore, this design has a relatively large size which makes insertion into the vessel difficult. Also, by having the two additional stents connected to the main stent, tracking into a wide-angle side branch may be difficult and may carry the risk of dissection of the vessel wall. Furthermore, once the device of the '071 patent is implanted, it is impossible to exchange the side branch stent should the need for a different stent size arise.
  • [0009]
    In general, when treating a bifurcation lesion using commercially available stents, great care should be taken to cover the origin of the branch because if left uncovered, this area is prone to restenosis. In order to cover the branch origin, conventional stents must either protrude into the lumen of the main artery or vessel from the branch (which may causes thrombosis [clotting of blood], again compromising blood flow), or they must be placed entirely within the branch, and will generally not cover the origin of the bifurcation. Another frequent complication experienced with the stenting of bifurcations include narrowing or occlusion of the origin of a side branch spanned by a stent placed in the main branch. Lastly, placement of a stent into a main vessel where the stent partially or completely extends across the opening of a branch may make future access into such branch vessels difficult if not impossible.
  • [0010]
    In addition, conventional stent technology is inadequate as a means of treating ostial lesions. Ostial lesions are lesions at the origin of a vessel. For example, ostial lesions may form in renal arteries, which are side branches extending from the aorta. Ostial lesions are prone to restenosis due to elastic recoil of the main vessel, such as the aorta. Therefore, the stent cover must include the thickness of the wall of the main vessel. This is extremely difficult to accomplish without protrusion of the stent into the main vessel.
  • [0011]
    Lastly, conventional stents are difficult to visualize during and after deployment. While some prior art balloon catheters are “marked” at the proximal and distal ends of the balloon with imageable patches, no FDA-approved stents are currently available which are themselves imageable through currently known imaging procedures used when inserting the stents into a vessel.
  • [0012]
    Accordingly, there is a need for an improved stent apparatus and method for deploying the same which 1) may be used to effectively treat bifurcation lesions which reduces the risk of restenosis or occlusion of the side branch and which completely covers bifurcation lesions with the stent apparatus, 2) may be used to treat lesions in one branch of a bifurcation while preserving access to the other branch for future treatment, 3) may be used to treat ostial lesions, 4) allows for differential sizing of the stents in a bifurcated stent apparatus even after the main stent is implanted, and which 5) may be readily visualized by current or future visualization techniques.
  • SUMMARY OF THE INVENTION
  • [0013]
    The present invention concerns a novel extendable stent apparatuses and method for deploying the same. More particularly, the invention concerns a stent apparatus comprising an extendable stent which is suitable for treating bifurcation lesions, and which may also be used to treat lesions at the origin of a blood vessel or other organ. As used herein, the term “vessel” means any tubular tissue, and is not limited to vessels of the vascular system. Devices constructed in accordance with the invention include, singularly or in combination, a flared stent comprising a compressible flared portion at its proximal end, which flared portion may comprise hooks, compressible mesh or any other means of creating such a flared portion at the proximal end of the stent, and a main stent comprising at least one substantially circular opening located between its proximal and distal ends. For ease of visualization, both the flared stent and the main stent may be comprised of materials which are imageable, or the stents of the invention may be “marked” at the ends with an imageable substance and the main stent may also be marked at any opening. At least one flared stent may be extended through at least one opening of the main stent into at least one branch vessel for treating bifurcated or branched lesions, or the stents of the invention may be inserted individually for the treatment of ostial lesions, or lesions near bifurcations requiring a stent in either the main or the branch vessel with unobstructed access to the unstented vessel in the bifurcation. The methods of the invention comprises a two-step process used to deploy both the main and the flared stent in a bifurcated vessel, or to deploy the main stent only within a bifurcated vessel.
  • [0014]
    The stent apparatus of the invention may be constructed from any non-immunoreactive material that allows the apparatus to be expanded from an initial shape to a shape which conforms to the shape of the vessel or vessels into which the apparatus is inserted, including but not limited to any of the materials disclosed in the prior art stents, which are incorporated herein by reference. It is hypothesized that the stent apparatuses of the invention may further be constructed of a substance which is observable by imaging methods including but not limited to magnetic resonance, ultrasound, radio-opaque or contrast-dye, or may be marked at certain points including but not limited to the ends and around any opening or flared portion in a stent of the invention, with a material which is discernable by imaging methods as described above.
  • [0015]
    A stent constructed in accordance with the invention is suitable for implantation into any vessel in the body, including but not limited to vessels in the cardiac system, the peripheral vascular system, the carotid and intracranial vessels, the venous system, the renal system, the biliary system, the gastrointestinal system, the tracheobronchial system, the biliary system and the genitourinary system.
  • [0016]
    The stents of the invention are deployed utilizing a set of guidewires and catheters, which are then withdrawn from the subject following deployment of the stents. The stents of the invention may be self-expanding to conform to the shape of the subject vessel, or they may be expanded utilizing balloon catheters, or by any method currently known or developed in the future which is effective for expanding the stents of the invention. The flared stent of the invention is constructed such that the flared portion is confined along the wall of the flared stent by a sheath running parallel to the longitudinal axis of the flared stent until deployment, during which the sheath is removed and the flared portion is expanded into a configuration extending radially, at least in part, from the longitudinal axis of the flared stent.
  • [0017]
    Thus, it is an object of the present invention to provide a double-stent apparatus which makes it possible to completely cover the origin of a bifurcation lesion with a stent apparatus.
  • [0018]
    Another object of the invention is to provide a single-stent apparatus and method for deploying the same which may be used to treat only one branch of a bifurcation lesion but which will facilitate future treatment of the corresponding branch.
  • [0019]
    Yet another object of the invention is to provide a single-stent apparatus which is effective in treating ostial lesions.
  • [0020]
    A further object of the invention is to provide a method for insertion of the extendable double-stent apparatus into both the main and branch vessels of a bifurcation lesion.
  • [0021]
    Additionally, it is an object of the invention to provide a stent apparatus which is imageable during and after insertion.
  • [0022]
    These objects and other object advantages and features of the invention will become better understood from the detailed description of the invention and the accompanying drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0023]
    [0023]FIG. 1 is a schematic depiction of the double-stent apparatus of the present invention in which both the main stent and the flared stent are fully dilated.
  • [0024]
    [0024]FIG. 2 is a schematic depiction of the main stent of the apparatus of the invention as deployed, without placement of the flared stent.
  • [0025]
    [0025]FIG. 3 is a schematic depiction of the flared stent of the apparatus as deployed, without the main stent.
  • [0026]
    [0026]FIG. 4 is a schematic depiction of the main stent of the apparatus deployed within a subject vessel.
  • [0027]
    [0027]FIG. 5 is a schematic depiction of the double-stent bifurcating stent apparatus, where the main stent is deployed and showing the placement of the flared stent apparatus prior to full deployment of the flared stent.
  • [0028]
    [0028]FIG. 6 is a schematic depiction of the method of the invention. FIG. 6a depicts initial placement of the main stent of the bifurcating stent apparatus into the vessel, along with the insertion of guidewire and stabilizing catheter for placement of the flared stent into the branch vessel of the subject.
  • [0029]
    [0029]FIG. 6b is a schematic depiction of the step of inflating the main stent of the invention.
  • [0030]
    [0030]FIG. 6c is a schematic depiction of the deployment of the flared stent over the side branch guidewire, through an opening in the main stent and into the branch vessel of the subject.
  • [0031]
    [0031]FIG. 6d is a schematic depiction of the removal of the protective sheath of the flared stent, allowing for full expansion of the flared portion prior to placement and deployment.
  • [0032]
    [0032]FIG. 6e is a schematic depiction of the fully extended flared stent positioned into the branch by the catheter, but prior to full deployment.
  • [0033]
    [0033]FIG. 6f is a schematic depiction of the fully dilated main stent and the fully positioned flared stent, where the flared stent is being dilated by inflation of the balloon
  • [0034]
    [0034]FIG. 6g is a schematic depiction of the fully dilated bifurcating double stent of the invention, positioned into the bifurcation in a subject vessel.
  • [0035]
    The rectilinear matrices shown in the drawings are intended to show the shapes of the surfaces only, and do not illustrate the actual surface patterns or appearances of the stent apparatuses of the invention.
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0036]
    The bifurcating double-stent apparatus 10 of the present invention comprises a generally cylindrical main stent 12 and a generally cylindrical flared stent 15, which are shown as fully dilated in a subject main vessel 8 and a subject branch vessel 7, as illustrated in FIG. 1.
  • [0037]
    The main stent 12 contains at least one generally circular opening 16 located between the proximal end 26 and the distal end 28 of the main stent 12 (FIG. 2), which opening is positioned over the opening 48 of a branch vessel in a vessel bifurcation 50, as shown in FIG. 2. The ends of the stent 12 and the opening are imaged during imaging procedures by placing markers 56 around the edges of the opening 16 in the main stent 12 and at the proximal end 26 and distal end 28 of the main stent, as illustrated in FIG. 4.
  • [0038]
    The flared stent apparatus 15 of the present invention comprises a generally cylindrical flared stent comprising a proximal end 30 and a distal end 32, as shown in FIG. 3. The proximal end 30 comprises a flared portion, illustrated here as extended loops 18, which flared portion, when dilated, is positioned within the lumen 58 of the main vessel 8 (FIG. 3). The ends of the flared stent 15 and the flared portion 18 are imaged during imaging procedures by placing markers 56 around the flared portion 18 and at the proximal-end 30 and distal end 32 of the flared stent, as illustrated in FIG. 5.
  • [0039]
    As shown in the embodiment of the invention illustrated in FIG. 4, a guidewire 20 is inserted into the vessel 8 prior to insertion of the main stent 12, and is used to guide the main stent 12 into position within the vessel 8. Prior to insertion and dilation, the main stent 12 is disposed around the distal end of a catheter 48 which may include an inflatable balloon 24. The main stent/catheter apparatus is then threaded onto the main guidewire 20 and into the vessel 8. The main stent 12 is dilated by inflation of the balloon 24 until it expands the walls of the vessel 8, and is thus affixed into place.
  • [0040]
    As shown in the embodiment of the invention illustrated in FIG. 5, prior to insertion of the flared stent 15, a guidewire 36 and a stabilizing catheter 44 are inserted through the opening 16 in the main stent 12, and into a branch vessel. The stabilizing catheter 44 is used to place the opening in the main stent 12 over the opening 16 in the bifurcation. The guidewire 36 is used to guide the flared stent 15 into position within a vessel. During insertion and prior to dilation, the flared stent 15 is disposed around the distal end of a branch catheter 54 which may include an inflatable balloon 25, and the flared portion 18 of the flared stent 15 is held in a compressed position by a protective sheath 34.
  • [0041]
    In the bifurcating double-stent apparatus 10 of the invention, once the main stent 12 is dilated and the stabilizing catheter 44 is removed, the flared stent 15 is inserted over the branch guidewire 36 and through the opening 16 of the main stent 12 substantially as shown in FIG. 5, and affixed in place by the expansion of the flared portion 18 positioned at the proximal end 30 of the flared stent, as shown in FIGS. 1 and 5. The angle at which the flared stent 15 is affixed depends upon the vessel structure into which the bifurcating stent apparatus 10 is inserted (FIG. 1).
  • [0042]
    The inventive two-stage method for implanting the novel bifurcating double-stent apparatus 10 begins with insertion of the main guidewire 20 into the subject main vessel 8 and across the bifurcation 50. Once the main guidewire 20 is in position in the main vessel 8, the main stent 12 is mounted around a catheter 48 (which may also comprise a balloon 24), and the catheter 48 and stent 12 are inserted into the main vessel 8. The stent 12 is positioned so that the opening 16 is directly over the bifurcation point 50 in the subject vessel (FIG. 6a). In order to aid such positioning, a side branch guidewire 36 and a stabilizing catheter 44 (as depicted in FIGS. 5 and 6) are also inserted through the opening 16 of the main stent 12 and into the branch vessel 7 (FIG. 6a).
  • [0043]
    In an alternative embodiment of the method of the invention, the main stent 12, the catheters 44 and 48 and the side branch guidewire 36 may be assembled in advance of insertion (with the stabilizing catheter 44 and the side branch guidewire positioned through the opening 16 of the main stent) into the subject, and then inserted into the bifurcation point 50 in the main vessel 8 simultaneously, after which the side branch guidewire 36 and the stabilizing catheter 44 are threaded into the branch vessel 7 in order to properly align the opening 16 in the main stent 12 (FIG. 6a).
  • [0044]
    To affix the main stent 12 in the desired position within the vessel 8, the stent 12 may be dilated by inflating the balloon 24 until the main stent 12 is in contact with the walls of the vessel 8 (FIG. 6b). Once the-main stent 12 is dilated, the catheters 44 and 48 are withdrawn, leaving the fully positioned main stent 12 and the main guidewire 20 in the main subject vessel, and the side branch guidewire 36 in the subject branch vessel (FIG. 6c).
  • [0045]
    In the second stage of the method of deploying the bifurcating double-stent of the invention, the flared stent catheter 54, containing the compressed flared stent 15 in a protective sheath 34 and which may further contain a balloon 25 disposed around the flared stent catheter 54 and inside the compressed flared stent 15, is inserted into the subject branch vessel 7 around the side branch guidewire 36 as shown in FIG. 6c. The compressed flared stent 15 is initially positioned so that the compressed proximal end 30 of the flared stent extends into the lumen 42 of the main stent 12 to facilitate full expansion of the flared portion 18 after withdrawal of the protective sheath 34, prior to the final positioning of the flared stent 15 into the branch of the bifurcation (FIG. 6c). The distal end 32 of the flared stent is initially positioned within the branch vessel 7 (FIG. 6c). After the proximal end 30 of the compressed flared stent is properly placed within the lumen 42 of the main stent, the protective sheath 34 is withdrawn from the vessel 8, and the flared portion 18 of the flared stent 15 is decompressed to extend radially, at least in part, to the longitudinal axis of the flared stent 15, as shown in FIG. 6d. After the flared portion 18 of the flared stent 15 is in its flared configuration (as shown in FIG. 6d), the flared stent 15 is advanced into the side branch 7 at its proximal end 30 until at least a portion of flared portion 18 of the flared sheath 15 contacts at least a portion of an edge of the opening 16 of the main stent 12, as shown in FIG. 6e. In this example, a balloon 25 is inflated in order to dilate the flared stent 15 to bring the walls of the flared stent 15 into contact with the walls of the branch vessel 7, as shown in FIG. 6f. All remaining catheters and guidewires are then withdrawn from the subject, leaving the fully deployed bifurcating double-stent apparatus of the invention 10, comprising the main stent 12 with at least one opening 16, and the flared stent 15 positioned through the opening 16 into the branch vessel 7, as shown in FIG. 6g.
  • [0046]
    When treating ostial lesions, the flared stent 15 alone is used, and is positioned utilizing catheters and guidewires as described above, except that a stabilizing catheter is not used, and the flared portion 18 of the flared stent is positioned at the ostium of a vessel, instead of into a side branch through the an opening 16 in a main branch. After the flared stent 15 is positioned near the ostium of a subject vessel, the protective sheath 34 is retracted in order to allow the flared portion to fully expanded and the flared stent 15 is further advanced with the proximal end of the catheter until the unfolded hooks 18 are in contact with the walls of the subject vessel.
  • [0047]
    All the stents of the invention may be deployed using the methods of the invention without resort to a balloon catheter. For example, a self-expanding compressed stent contained within a protective sheath could be self-dilated by retraction of a protective sheath. Other methods of dilation of the stents of the invention may exist, or may become available in the future, and such methods are contemplated as being within the scope of this invention. While this example used self-unfolding loops to demonstrate one means of creating a flared portion, any other means of creating a flare, such as but not limited to creating a roll in the stent material which is then compressed, is contemplated as within the scope of this invention.
  • [0048]
    It is the intent that the invention include all modifications and alterations from the disclosed embodiments that fall within the scope of the claims of the invention.
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US683520313 Jan 199928 Dec 2004Advanced Stent Technologies, Inc.Extendible stent apparatus
US734451417 Aug 200418 Mar 2008Innovational Holdings, LlcExpandable medical device delivery system and method
US7344557 *10 Nov 200418 Mar 2008Advanced Stent Technologies, Inc.Catheter balloon systems and methods
US74252198 Oct 200416 Sep 2008Arshad QuadriSystem and method for endoluminal grafting of bifurcated and branched vessels
US747912728 Oct 200420 Jan 2009Innovational Holding, LlcExpandable medical device delivery system and method
US764168427 Apr 20045 Jan 2010Minvasys, SaCatheter system for stenting bifurcated vessels
US765503029 Apr 20042 Feb 2010Boston Scientific Scimed, Inc.Catheter balloon systems and methods
US76781424 Aug 200416 Mar 2010Boston Scientific Scimed, Inc.Extendible stent apparatus
US771794923 Sep 200418 May 2010C. R. Bard, Inc.Lining for bodily lumen
US771795313 Oct 200418 May 2010Tryton Medical, Inc.Delivery system for placement of prosthesis at luminal OS
US77317418 Sep 20058 Jun 2010Boston Scientific Scimed, Inc.Inflatable bifurcation stent
US77317479 Mar 20058 Jun 2010Tryton Medical, Inc.Vascular bifurcation prosthesis with multiple thin fronds
US775863021 Nov 200620 Jul 2010Tryton Medical, Inc.Helical ostium support for treating vascular bifurcations
US775863421 Mar 200720 Jul 2010Boston Scientific Scimed, Inc.Bifurcated stent and delivery system
US776695519 May 20033 Aug 2010Boston Scientific Scimed, Inc.Extendible stent apparatus
US777146215 Sep 200010 Aug 2010Boston Scientific Scimed, Inc.Catheter with side sheath and methods
US7771465 *23 Jun 200610 Aug 2010Gore Enterprise Holdings, Inc.Branched stent delivery system
US781567510 Mar 200819 Oct 2010Boston Scientific Scimed, Inc.Stent with protruding branch portion for bifurcated vessels
US78332646 Mar 200616 Nov 2010Boston Scientific Scimed, Inc.Bifurcated stent
US783326628 Nov 200716 Nov 2010Boston Scientific Scimed, Inc.Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US784208127 Nov 200630 Nov 2010Boston Scientific Scimed, Inc.Stent with spiral side-branch
US784208230 Aug 200730 Nov 2010Boston Scientific Scimed, Inc.Bifurcated stent
US785072515 Jun 200614 Dec 2010Boston Scientific Scimed, Inc.Extendible stent apparatus
US789227926 May 200922 Feb 2011Boston Scientific Scimed, Inc.Extendible stent apparatus
US792275417 Apr 200612 Apr 2011Trireme Medical, Inc.Apparatus and methods for delivering prostheses to luminal bifurcations
US792275820 Jun 200712 Apr 2011Boston Scientific Scimed, Inc.Nesting twisting hinge points in a bifurcated petal geometry
US79511915 Sep 200731 May 2011Boston Scientific Scimed, Inc.Bifurcated stent with entire circumferential petal
US795119225 Aug 200931 May 2011Boston Scientific Scimed, Inc.Stent with protruding branch portion for bifurcated vessels
US795966816 Jan 200714 Jun 2011Boston Scientific Scimed, Inc.Bifurcated stent
US795966912 Sep 200714 Jun 2011Boston Scientific Scimed, Inc.Bifurcated stent with open ended side branch support
US797236920 Jul 20075 Jul 2011Tryton Medical, Inc.Method for delivering a luminal prosthesis
US79723724 May 20075 Jul 2011Tryton Medical, Inc.Kit for treating vascular bifurcations
US800752823 May 200730 Aug 2011Boston Scientific Scimed, Inc.Bifurcated stent
US80168781 Jun 200913 Sep 2011Boston Scientific Scimed, Inc.Bifurcation stent pattern
US80387068 Sep 200518 Oct 2011Boston Scientific Scimed, Inc.Crown stent assembly
US80433668 Sep 200525 Oct 2011Boston Scientific Scimed, Inc.Overlapping stent
US8080049 *9 Nov 200620 Dec 2011Gore Enterprise Holdings, Inc.Branched stent delivery system
US808379127 Jul 200527 Dec 2011Tryton Medical, Inc.Method of treating a lumenal bifurcation
US810998712 Oct 20057 Feb 2012Tryton Medical, Inc.Method of treating a lumenal bifurcation
US811886128 Mar 200721 Feb 2012Boston Scientific Scimed, Inc.Bifurcation stent and balloon assemblies
US818731429 Jan 200929 May 2012Tryton Medical, Inc.Prothesis and deployment catheter for treating vascular bifurcations
US82064292 Nov 200626 Jun 2012Boston Scientific Scimed, Inc.Adjustable bifurcation catheter incorporating electroactive polymer and methods of making and using the same
US821116723 Jan 20043 Jul 2012Boston Scientific Scimed, Inc.Method of using a catheter with attached flexible side sheath
US821626712 Sep 200610 Jul 2012Boston Scientific Scimed, Inc.Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US82162951 Jul 200910 Jul 2012Endologix, Inc.Catheter system and methods of using same
US822149420 Feb 200917 Jul 2012Endologix, Inc.Apparatus and method of placement of a graft or graft system
US823604011 Apr 20087 Aug 2012Endologix, Inc.Bifurcated graft deployment systems and methods
US82413493 Feb 201114 Aug 2012Boston Scientific Scimed, Inc.Extendible stent apparatus
US825203820 Jul 200728 Aug 2012Tryton Medical, Inc.System for delivering a prosthesis to a luminal OS
US82574254 Dec 20064 Sep 2012Boston Scientific Scimed, Inc.Stent with protruding branch portion for bifurcated vessels
US825743214 May 20104 Sep 2012Tryton Medical, Inc.Vascular bifurcation prosthesis with at least one frond
US827750121 Dec 20072 Oct 2012Boston Scientific Scimed, Inc.Bi-stable bifurcated stent petal geometry
US828758228 Apr 200416 Oct 2012C. R. Bard, Inc.Loading and delivery of self-expanding stents
US82982787 Mar 200630 Oct 2012Boston Scientific Scimed, Inc.Bifurcated stent with improvement securement
US829828014 Dec 200430 Oct 2012Boston Scientific Scimed, Inc.Stent with protruding branch portion for bifurcated vessels
US831785526 May 200527 Nov 2012Boston Scientific Scimed, Inc.Crimpable and expandable side branch cell
US834321114 Dec 20051 Jan 2013Boston Scientific Scimed, Inc.Connectors for bifurcated stent
US835719211 Mar 201122 Jan 2013Endologix, Inc.Bifurcated graft deployment systems and methods
US83667631 Jul 20105 Feb 2013Tryton Medical, Inc.Ostium support for treating vascular bifurcations
US83771082 Jun 200819 Feb 2013Boston Scientific Scimed, Inc.Staggered two balloon bifurcation catheter assembly and methods
US83828181 Jul 201026 Feb 2013Tryton Medical, Inc.Ostium support for treating vascular bifurcations
US842559031 May 201123 Apr 2013Boston Scientific Scimed, Inc.Stent with protruding branch portion for bifurcated vessels
US843528414 Dec 20057 May 2013Boston Scientific Scimed, Inc.Telescoping bifurcated stent
US848072826 May 20059 Jul 2013Boston Scientific Scimed, Inc.Stent side branch deployment initiation geometry
US84861341 Aug 200716 Jul 2013Boston Scientific Scimed, Inc.Bifurcation treatment system and methods
US852393112 Jan 20073 Sep 2013Endologix, Inc.Dual concentric guidewire and methods of bifurcated graft deployment
US85296183 Sep 200910 Sep 2013Tryton Medical, Inc.Ostium support for treating vascular bifurcations
US855695522 Jun 201215 Oct 2013Boston Scientific Scimed, Inc.Adjustable bifurcation catheter incorporating electroactive polymer and methods of makings and using the same
US860878923 May 200617 Dec 2013Trireme Medical, Inc.Delivery system for bifurcation stents
US86087919 Mar 201117 Dec 2013Trireme Medical, Inc.Apparatus and methods for delivering prostheses to luminal bifurcations
US861723125 Sep 200331 Dec 2013Boston Scientific Scimed, Inc.Dual guidewire exchange catheter system
US864175129 Jan 20094 Feb 2014Tryton Medical, Inc.Vascular bifurcation prosthesis with multiple linked thin fronds
US86417554 May 20074 Feb 2014Tryton Medical, Inc.Prosthesis for treating vascular bifurcations
US864737630 Mar 200711 Feb 2014Boston Scientific Scimed, Inc.Balloon fold design for deployment of bifurcated stent petal architecture
US867298911 Jul 201218 Mar 2014Endologix, Inc.Apparatus and method of placement of a graft or graft system
US867299413 Oct 200518 Mar 2014Tryton Medical, Inc.Prosthesis for treating vascular bifurcations
US867917227 Jan 201025 Mar 2014C. R. Bard, Inc.Delivery device for delivering a stent device
US870277911 Jan 200822 Apr 2014Boston Scientific Scimed, Inc.Catheter balloon systems and methods
US874745631 Dec 200810 Jun 2014Boston Scientific Scimed, Inc.Bifurcation stent delivery system and methods
US876481218 Jan 20131 Jul 2014Endologix, Inc.Bifurcated graft deployment systems and methods
US877133415 Dec 20098 Jul 2014Boston Scientific Scimed, Inc.Catheter balloon systems and methods
US87713428 Sep 20098 Jul 2014Boston Scientific Scimed, Inc.Methods for deploying stents in bifurcations
US882156121 Feb 20072 Sep 2014Boston Scientific Scimed, Inc.Marker arrangement for bifurcation catheter
US88279545 Jun 20099 Sep 2014Boston Scientific Scimed, Inc.Deflatable bifurcated device
US886481220 May 201321 Oct 2014W.L. Gore & Associates, Inc.Branched stent delivery system
US88768844 May 20074 Nov 2014Tryton Medical, Inc.Prosthesis and deployment catheter for treating vascular bifurcations
US892048428 May 201030 Dec 2014C. R. Bard, Inc.Transluminal delivery system
US892668527 Apr 20106 Jan 2015Tryton Medical, Inc.Prosthesis for placement at a luminal OS
US893234029 May 200813 Jan 2015Boston Scientific Scimed, Inc.Bifurcated stent and delivery system
US89365675 Jun 200920 Jan 2015Boston Scientific Scimed, Inc.Balloon bifurcated lumen treatment
US894520228 Apr 20103 Feb 2015Endologix, Inc.Fenestrated prosthesis
US8956399 *11 May 201217 Feb 2015Covidien LpVascular remodeling device
US907262310 Oct 20127 Jul 2015C. R. Bard, Inc.Loading and delivery of self-expanding stents
US910150020 Feb 200911 Aug 2015Trireme Medical, Inc.Stent with self-deployable portion having wings of different lengths
US911403310 Jan 200625 Aug 2015Trireme Medical, Inc.Stent with self-deployable portion
US914937325 Feb 20136 Oct 2015Tryton Medical, Inc.Method of treating vascular bifurcations
US91493814 Feb 20146 Oct 2015Endologix, Inc.Apparatus and method of placement of a graft or graft system
US9168160 *30 Jan 201327 Oct 2015Cook Medical Technologies LlcImplantable medical device with fenestration and radiopaque marker coils on stents
US927801523 Apr 20078 Mar 2016MinvasysCatheter system for stenting and drug treatment of bifurcated vessels
US933940215 Nov 201317 May 2016TriReme Medical, LLCApparatus and methods for delivering prostheses to luminal bifurcations
US93581407 Dec 20147 Jun 2016Aneuclose LlcStent with outer member to embolize an aneurysm
US942734014 Feb 200730 Aug 2016Boston Scientific Scimed, Inc.Stent with protruding branch portion for bifurcated vessels
US949229713 Jun 201215 Nov 2016Boston Scientific Scimed, Inc.Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US20050059991 *28 Oct 200417 Mar 2005Shanley John F.Expandable medical device delivery system and method
US20050085845 *27 Apr 200421 Apr 2005Minvasys, SaCatheter system for stenting bifurcated vessels
US20050154444 *8 Oct 200414 Jul 2005Arshad QuadriSystem and method for endoluminal grafting of bifurcated and branched vessels
US20060047335 *26 Aug 20042 Mar 2006Israel Henry MCatheter with deflector
US20060116748 *12 Oct 20051 Jun 2006Aaron KaplanStepped balloon catheter for treating vascular bifurcations
US20060173528 *10 Jan 20063 Aug 2006Trireme Medical, Inc.Stent with self-deployable portion
US20060253480 *8 May 20069 Nov 2006Staples Peter ECollaborative design process for a design team, outside suppliers, and outside manufacturers
US20060259123 *23 Sep 200416 Nov 2006C. R. Bard, Inc.Lining for bodily lumen
US20070032862 *22 Mar 20068 Feb 2007Jan WeberMedical devices
US20070250001 *21 May 200525 Oct 2007Pierre HilaireGuidewire Separator Device and Method of Use
US20070282419 *23 Apr 20076 Dec 2007Minvasys, SaCatheter system for stenting and drug treatment of bifurcated vessels
US20070299494 *23 Jun 200627 Dec 2007Stanislaw ZukowskiBranched stent delivery system
US20070299495 *9 Nov 200627 Dec 2007Stanislaw ZukowskiBranched stent delivery system
US20080147174 *11 Dec 200719 Jun 2008Trireme Medical, Inc.Apparatus and method of using markers to position stents in bifurcations
US20090182409 *20 Feb 200916 Jul 2009Trireme Medical, Inc.Stent with self-deployable portion having wings of different lengths
US20100069853 *18 Nov 200918 Mar 2010Stanislaw ZukowskiBranched Stent Delivery System
US20100070016 *15 Sep 200918 Mar 2010C. R. Bard, Inc.Stent device adhesively bonded to a stent device pusher
US20110054438 *28 Aug 20093 Mar 2011Webster Mark W IStent delivery at a bifurcation, systems and methods
US20110160837 *9 Mar 201130 Jun 2011Trireme Medical, Inc.Apparatus and methods for delivering prostheses to luminal bifurcations
US20120290067 *11 May 201215 Nov 2012Tyco Healthcare Group LpVascular remodeling device
US20130197627 *30 Jan 20131 Aug 2013Cook Medical Technologies LlcImplantable medical device
WO2005030092A3 *23 Sep 200421 Jul 2005Angiomed AgLining for bodily lumen
Classifications
U.S. Classification623/1.11, 623/1.35
International ClassificationA61F2/82, A61F2/06, A61F2/00
Cooperative ClassificationA61F2250/0098, A61F2250/006, A61F2002/91533, A61F2002/91525, A61F2002/821, A61F2/958, A61F2/954, A61F2/915, A61F2/91, A61F2/856, A61F2/852, A61F2/82, A61F2/064, A61F2002/91516, A61F2002/91508, A61F2002/067, A61F2002/91575, A61F2002/91583, A61F2002/9155, A61F2002/91558, A61F2/07
European ClassificationA61F2/954, A61F2/958, A61F2/91, A61F2/856, A61F2/915