US20010055604A1 - Gel formulations containing insecticide - Google Patents
Gel formulations containing insecticide Download PDFInfo
- Publication number
- US20010055604A1 US20010055604A1 US09/462,958 US46295800A US2001055604A1 US 20010055604 A1 US20010055604 A1 US 20010055604A1 US 46295800 A US46295800 A US 46295800A US 2001055604 A1 US2001055604 A1 US 2001055604A1
- Authority
- US
- United States
- Prior art keywords
- gel
- insecticidal
- active compound
- vaporization
- rapeseed oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 238000009472 formulation Methods 0.000 title claims abstract description 34
- 239000002917 insecticide Substances 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 29
- 230000000749 insecticidal effect Effects 0.000 claims abstract description 13
- 238000013270 controlled release Methods 0.000 claims abstract description 4
- 238000013268 sustained release Methods 0.000 claims abstract description 4
- 239000012730 sustained-release form Substances 0.000 claims abstract description 4
- 238000009834 vaporization Methods 0.000 claims description 12
- 230000008016 vaporization Effects 0.000 claims description 12
- 239000003607 modifier Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 9
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- DDVNRFNDOPPVQJ-HQJQHLMTSA-N transfluthrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=CC(F)=C1F DDVNRFNDOPPVQJ-HQJQHLMTSA-N 0.000 claims description 8
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 claims description 7
- 239000003086 colorant Substances 0.000 claims description 7
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 6
- 239000002304 perfume Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 150000004702 methyl esters Chemical class 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 description 10
- 238000003756 stirring Methods 0.000 description 8
- -1 polypropylene Polymers 0.000 description 6
- 241000255925 Diptera Species 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- RGCKGOZRHPZPFP-UHFFFAOYSA-N alizarin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000006200 vaporizer Substances 0.000 description 3
- KWBCXNHXXWZCMM-UHFFFAOYSA-N 1,4-bis(4-tert-butylanilino)-5,8-dihydroxyanthracene-9,10-dione Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(C=1C(=O)C2=C(O)C=CC(O)=C2C(=O)C=11)=CC=C1NC1=CC=C(C(C)(C)C)C=C1 KWBCXNHXXWZCMM-UHFFFAOYSA-N 0.000 description 2
- FBMQNRKSAWNXBT-UHFFFAOYSA-N 1,4-diaminoanthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(N)=CC=C2N FBMQNRKSAWNXBT-UHFFFAOYSA-N 0.000 description 2
- 229910002012 Aerosil® Inorganic materials 0.000 description 2
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000011296 birch-tar Substances 0.000 description 2
- 239000010632 citronella oil Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 2
- BFBPISPWJZMWJN-UHFFFAOYSA-N methyl 2-[(7-hydroxy-3,7-dimethyloctylidene)amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1N=CCC(C)CCCC(C)(C)O BFBPISPWJZMWJN-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000002728 pyrethroid Substances 0.000 description 2
- 235000019719 rose oil Nutrition 0.000 description 2
- 239000010666 rose oil Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000256118 Aedes aegypti Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229910003480 inorganic solid Inorganic materials 0.000 description 1
- 239000003350 kerosene Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/10—Insect repellent
Definitions
- the present invention relates to novel insecticidal gel formulations for the controlled and sustained release of insecticidal active compounds by means of a heat source.
- These novel gel formulations are characterized in that they comprise at least one type of insecticide and at least one vaporization-controlling substance (vaporization modifier), in combination with a solid suitable as a gel former.
- the present invention is based on known gel formulations as described in EP 0 693 254, where insecticidally active compounds with novel, alternative solvents in combination with perfumes, colorants and auxiliaries are to display an optimum effect without decomposition for a relatively long period of time.
- This novel active compound formulation is to be used in deep-drawn or cast containers made of polymer or metal, these containers being open or closed by means of suitable fabrics, films made of polymer, for example polypropylene film, or metal, which are permeable to the volatile components, as described in EP 0 693 254.
- These deep-drawn containers can be used in an electrical heating device for killing insects, for example mosquitoes.
- a considerable disadvantage of these tablet vaporizers is the unfavourable ratio between energy input and active compound to be vaporized, since the proportion of active compound relative to the auxiliaries is to be considered as low. Furthermore, the high working temperature of these tablet vaporizers means that only few active compounds are suitable for this purpose in the first place, and that, moreover, these active compounds are released over the predetermined period of action in a non-uniform manner, for system reasons. The period of action of these vaporizer tablets is limited to a maximum of 12 hours. Finally, the unfavourable ratio of active compound/active compound carrier requires a substantial, constantly available stock of vaporizer tablets, which means that large amounts of material are necessary as carriers and packaging material.
- vapour-producing systems Apart from the fact that these vapour-producing systems also operate at temperatures of between 120 and 190° C., they require a specific distribution system (wick) and considerable amounts of solvents. When the product is used, the superproportional amount of solvent relative to the active compound results in a high concentration of solvents or adjuvants in the room, which, in turn, leads to dirtying of walls and objects in the vicinity of these devices, which has frequently been observed by customers and given cause for complaint.
- EP 0 693 254 mentions gel formulations which have the disadvantage that they persist for a long time indoors and that they additionally consist of very expensive components.
- novel insecticide-comprising gel formulations according to the invention include mixtures which comprise at least one type of a pyrethroid insecticide, a vaporization-controlling substance and an inorganic solid suitable as a gel former.
- Suitable active compounds which can be used are the active compounds mentioned in EP 0 693 254.
- compositions with the active compound transfluthrin (Bayothrin®, 2,3,5,6-tetrafluorobenzyl (+)-1R-trans-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate) having a reduced active compound content and in combination with novel vaporization-controlling substances, also referred to as vaporization modifiers, which have a strongly reduced risk potential during processing and which are furthermore rapidly degradable indoors.
- active compound transfluthrin Boyothrin®, 2,3,5,6-tetrafluorobenzyl (+)-1R-trans-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate
- Preferred novel vaporization modifiers are medicinal white oils CAS No. 804247-5 (BP Enerpar M002®) and high-pressure hydrogenated mineral oils CAS No. 804247-5 (Enerpar M1930®).
- the formulations generally comprise between 1.0 and 95% by weight of insecticidally active compound, preferably between 5.0 and 80%, in particular from 20 to 50% by weight.
- the formulations furthermore generally comprise between 10 and 90% by weight of vaporization modifiers, preferably between 40 and 80%, and generally between 1 and 12% of gel former, preferably between 6 and 10%.
- the ratio of active compound/vaporization modifier in the insecticide-comprising gel formulations according to the invention is between 9 and 0.1; preferably between 2.0 and 0.2.
- the formulations must have an optimum storage stability over a long period of time.
- the gel formulations according to the invention are prepared by first stirring at room temperature in a suitable mixing apparatus (planetary paddle mixer) the active compound with the vaporization modifier and stabilizer and, if appropriate, additional solvents, to give a clear solution. Then, the gel former is added under reduced pressure, and the mixture is stirred vigorously until a homogeneous gel is formed. Before the gel former is mixed in to give the final gel product, perfume oils and colorants can optionally be added to the existing clear solution with stirring until the mixture is completely homogeneous.
- a suitable mixing apparatus planetary paddle mixer
- the film container with the coloured gel is inserted into a heating device whose front is transparent or fitted with an inspection opening.
- the content of the film container which is not visible through a colour marking on the container itself or on the heating device, dries out.
- a further variant for visual identification of the end point using added colorants may also take the form of a change in colour when the active compounds and, if appropriate, the solvent have vaporized.
- Formulations having Novel Vaporization Modifiers Example Insecticide content Gel former Stabilizer Vaporization modifier 1.1. 25% Transfluthrin ® 6% Aerosil 200 ® 1% BHT 64% Enerpar M002 ® 1.2. 25% Transfluthrin ® 8% Aerosil COK 84 ® 1% BHT 64% Guerbitol 16 ®
- insecticide-comprising gel formulations can be prepared as follows:
- 6 kg of Aerosil 200 are introduced into the clear solution under reduced pressure until a gel has formed.
- 8 kg of Aerosil COK 84® are introduced into the clear solution under reduced pressure until a gel has formed.
- the gel formulations are, depending on the duration of use, filled into deep-drawn or cast containers generally in amounts of 0.2-0.5 g, preferably in amounts of 0.2-0.3 g, and sealed with polypropylene film.
- Preferred container materials are aluminium, polyester, polyethylene, metals.
- the dimensions of the container are chosen such that the area of the bottom of the container has the same size as the heating area of the heating device and transfers temperatures of from 70 to 112° C.
- 1.6 g of the insecticide-comprising gel formulations are uniformly distributed on the surface of deep-drawn aluminium container having the dimensions (4 ⁇ 2.5 ⁇ 0.4 cm) and sealed with the PP film Walothen C5OSE® or Trespaphan 6ND50®.
- a heating device having a temperature of 100-112° C., the container is heated for 8 hours each day, and the release rates of the formulation are determined.
- Example 1.1 Example 1.2 Cycle Weight loss per hour in mg 1 4.6 4.6 2 4.8 4.5 3 4.1 4.4 4 4.1 4.3 5 3.2 4.8 8 3.2 4.4 10 3.2 4.3 12 3.2 4.1 14 2.7 4.0 16 2.5 3.8 18 2.4 3.5 20 2.2 3.5 22 2.0 3.9 24 2.0 3.8 26 2.0 3.4 28 2.1 3.3 30 1.4 2.9 32 1.2 2.6 34 1.3 2.5 36 1.2 2.7 38 1.0 2.3 40 1.1 2.2 42 0.9 2.2 44 0.8 1.6 46 0.8 1.3 48 0.8 1.2 50 0.6 1.0
Abstract
Description
- The present invention relates to novel insecticidal gel formulations for the controlled and sustained release of insecticidal active compounds by means of a heat source. These novel gel formulations are characterized in that they comprise at least one type of insecticide and at least one vaporization-controlling substance (vaporization modifier), in combination with a solid suitable as a gel former.
- The present invention is based on known gel formulations as described in EP 0 693 254, where insecticidally active compounds with novel, alternative solvents in combination with perfumes, colorants and auxiliaries are to display an optimum effect without decomposition for a relatively long period of time.
- This novel active compound formulation is to be used in deep-drawn or cast containers made of polymer or metal, these containers being open or closed by means of suitable fabrics, films made of polymer, for example polypropylene film, or metal, which are permeable to the volatile components, as described in EP 0 693 254. These deep-drawn containers can be used in an electrical heating device for killing insects, for example mosquitoes.
- In the case where mosquitoes are killed using an electrical heating device, a so-called tablet vaporizer, it is generally known that specifically selected substances, such as cellulose board and cotton board, asbestos, ceramics and/or porous synthetic resins are impregnated with pyrethroid insecticides to obtain insecticide tablets, the insecticides being volatilized by the action of the mosquito killing heating device, which generates a temperature of 120-190° C.
- A considerable disadvantage of these tablet vaporizers is the unfavourable ratio between energy input and active compound to be vaporized, since the proportion of active compound relative to the auxiliaries is to be considered as low. Furthermore, the high working temperature of these tablet vaporizers means that only few active compounds are suitable for this purpose in the first place, and that, moreover, these active compounds are released over the predetermined period of action in a non-uniform manner, for system reasons. The period of action of these vaporizer tablets is limited to a maximum of 12 hours. Finally, the unfavourable ratio of active compound/active compound carrier requires a substantial, constantly available stock of vaporizer tablets, which means that large amounts of material are necessary as carriers and packaging material.
- The devices which are already widely used for domestic purposes, in which a solution of an insecticidally active compound is vaporized by means of a heated wick (GB 2 153 227), where the active compound is dissolved in a kerosene mixture of saturated aliphatic hydrocarbons which is vaporized electrically by means of the wick, also have considerable disadvantages.
- Apart from the fact that these vapour-producing systems also operate at temperatures of between 120 and 190° C., they require a specific distribution system (wick) and considerable amounts of solvents. When the product is used, the superproportional amount of solvent relative to the active compound results in a high concentration of solvents or adjuvants in the room, which, in turn, leads to dirtying of walls and objects in the vicinity of these devices, which has frequently been observed by customers and given cause for complaint.
- Other disadvantages of these formulations are the high volume of the solvent containers and the risk of the solvent leaking, which means that there are substantial problems during transport and hazards in use.
- Furthermore, EP 0 693 254 mentions gel formulations which have the disadvantage that they persist for a long time indoors and that they additionally consist of very expensive components.
- The novel insecticide-comprising gel formulations according to the invention include mixtures which comprise at least one type of a pyrethroid insecticide, a vaporization-controlling substance and an inorganic solid suitable as a gel former.
- Suitable active compounds which can be used are the active compounds mentioned in EP 0 693 254.
- Particularly suitable here are formulations with the active compound transfluthrin (Bayothrin®, 2,3,5,6-tetrafluorobenzyl (+)-1R-trans-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate) having a reduced active compound content and in combination with novel vaporization-controlling substances, also referred to as vaporization modifiers, which have a strongly reduced risk potential during processing and which are furthermore rapidly degradable indoors.
- Preferred novel vaporization modifiers are medicinal white oils CAS No. 804247-5 (BP Enerpar M002®) and high-pressure hydrogenated mineral oils CAS No. 804247-5 (Enerpar M1930®).
- Particular preference is given to naturally regrowing raw materials such as rapeseed oil, rapeseed oil methyl ester and colourless to slightly yellowish Guerbet alcohol of liquid/solid consistency having a very weak intrinsic odour, CAS No.: 67 187-86-0 (Guerbitol 32/36®), colourless to slightly yellowish Guerbet aalcohol of liquid consistency having very weak intrinsic odour=2-hexyldecan-1-ol, CAS No.: 36311-34-9 (Guerbitol 16®).
- Particular preference is given to colourless to slightly yellowish Guerbet alcohol of liquid consistency=2-hexyldecan-1-ol, CAS No.: 36311-34-9 (Guerbitol 16®).
- The formulations generally comprise between 1.0 and 95% by weight of insecticidally active compound, preferably between 5.0 and 80%, in particular from 20 to 50% by weight.
- The formulations furthermore generally comprise between 10 and 90% by weight of vaporization modifiers, preferably between 40 and 80%, and generally between 1 and 12% of gel former, preferably between 6 and 10%.
- The ratio of active compound/vaporization modifier in the insecticide-comprising gel formulations according to the invention is between 9 and 0.1; preferably between 2.0 and 0.2.
- It is furthermore possible to add organic or inorganic auxiliaries, stabilizers, perfumes and colorants, as described in EP 0 693 254, inter alia, to these mixtures.
- The formulations must have an optimum storage stability over a long period of time.
- The gel formulations according to the invention are prepared by first stirring at room temperature in a suitable mixing apparatus (planetary paddle mixer) the active compound with the vaporization modifier and stabilizer and, if appropriate, additional solvents, to give a clear solution. Then, the gel former is added under reduced pressure, and the mixture is stirred vigorously until a homogeneous gel is formed. Before the gel former is mixed in to give the final gel product, perfume oils and colorants can optionally be added to the existing clear solution with stirring until the mixture is completely homogeneous.
- For use, the film container with the coloured gel is inserted into a heating device whose front is transparent or fitted with an inspection opening.
- During the use of the heating device, the content of the film container, which is not visible through a colour marking on the container itself or on the heating device, dries out.
- Only the empty film container is still visible through the transparent front of the heating device or through the inspection opening.
- A further variant for visual identification of the end point using added colorants may also take the form of a change in colour when the active compounds and, if appropriate, the solvent have vaporized.
- The present invention is to be illustrated by the present examples:
- Formulations having Novel Vaporization Modifiers
Example Insecticide content Gel former Stabilizer Vaporization modifier 1.1. 25% Transfluthrin ® 6% Aerosil 200 ® 1% BHT 64% Enerpar M002 ® 1.2. 25% Transfluthrin ® 8% Aerosil COK 84 ® 1% BHT 64% Guerbitol 16 ® - The insecticide-comprising gel formulations can be prepared as follows:
- 2.1
- For a 100 kg batch, 25 kg of liquid Transfluthrin® (temperature about 40° C.) are initially charged in a stirring apparatus, 64 kg of Enerpar M002® and 1 kg of BHT are added and the mixture is stirred to give a clear solution. Additionally, it is possible to stir into the formulation preferably the perfume oils aurantiol, citronella oil, C10-C16 aldehyde, birch tar oil, benzyl salicylate, lavender oil or rose oil in combination with, or without, the colorants Hostasol yellow®, Resolin-brilliant red BLS®, 1,4-diaminoanthraquinone, Alizarin VK6/225, Fatty Red HRR®, Fatty Red G®, Solvaperm Green G or Sudan Blue 670®. With rapid stirring, 6 kg of Aerosil 200 are introduced into the clear solution under reduced pressure until a gel has formed.
- 2.2
- For a 100 kg batch, 25 kg of liquid Transfluthrin® (temperature) about 40° C. are initially charged in a stirring apparatus, 64 kg of Guerbitol 16® and 1 kg of BHT are added and the mixture is stirred to give a clear solution. Additionally, it is possible to stir into the formulation preferably the perfume oils aurantiol, citronella oil, C10-C16 aldehyde, birch tar oil, benzyl salicylate, lavender oil or rose oil in combination with, or without, the colorants Hostasol yellow®, Resolin-brilliant red BLS®, 1,4-diaminoanthraquinone, Alizarin VK6/225, Fatty Red HRR®, Fatty Red G®, Solvaperm Green G or Sudan Blue 670®. With rapid stirring, 8 kg of Aerosil COK 84® are introduced into the clear solution under reduced pressure until a gel has formed.
- For use, the gel formulations are, depending on the duration of use, filled into deep-drawn or cast containers generally in amounts of 0.2-0.5 g, preferably in amounts of 0.2-0.3 g, and sealed with polypropylene film. Preferred container materials are aluminium, polyester, polyethylene, metals. The dimensions of the container are chosen such that the area of the bottom of the container has the same size as the heating area of the heating device and transfers temperatures of from 70 to 112° C.
- The controlled and sustained release of insecticidally active compounds is effected by using Examples 2.1 and 2.2 as follows:
- 1.6 g of the insecticide-comprising gel formulations are uniformly distributed on the surface of deep-drawn aluminium container having the dimensions (4×2.5×0.4 cm) and sealed with the PP film Walothen C5OSE® or Trespaphan 6ND50®. In a heating device having a temperature of 100-112° C., the container is heated for 8 hours each day, and the release rates of the formulation are determined.
- The results of the vaporization tests are shown in Example 3.
- Release Rates of the Formulations from Example 1.1 and 1.2 in [mg/h]
Heater temperatures: 105-107° C. Voltage: 230 V Room temperature: 20-22° C. Duration of the cycle: 8 h Cycle pause: 4 h Weighed-out formulation: 1.6 g -
Example 1.1 Example 1.2 Cycle Weight loss per hour in mg 1 4.6 4.6 2 4.8 4.5 3 4.1 4.4 4 4.1 4.3 5 3.2 4.8 8 3.2 4.4 10 3.2 4.3 12 3.2 4.1 14 2.7 4.0 16 2.5 3.8 18 2.4 3.5 20 2.2 3.5 22 2.0 3.9 24 2.0 3.8 26 2.0 3.4 28 2.1 3.3 30 1.4 2.9 32 1.2 2.6 34 1.3 2.5 36 1.2 2.7 38 1.0 2.3 40 1.1 2.2 42 0.9 2.2 44 0.8 1.6 46 0.8 1.3 48 0.8 1.2 50 0.6 1.0 - Biological Effect on Mosquitoes of the Variety Aedes Aegypti, Sensitive
Room size: 36 m3 Kind of room: 1 window, open temperature: 20-28° C. rel. humidity in the room: 17-34% heater temperature: 105-110° C. content of active compound: 25% of transfluthrin weighed-out formulation: 1.6 g -
Duration of operation/ Formulation 1.1 Formulation 1.2 Examination Mosquitoes KD effect after KD effect after after days released min or h % dead after min or h % dead after (hours) after hours 50% 100% 9 h 24 h 50% 100% 9 h 24 h 1 day 0 1 h 03′ 1 h 15′ 100 100 1 h 14′ 2 h 02′ 100 100 1 19′ 1 h 05′ 100 100 39′ 59′ 100 100 2 10′ 17′ 100 100 11′ 16′ 100 100 3 4′ 7′ 100 100 32′ 45′ 100 100 4 4′ 7′ 100 100 9′ 17′ 100 100 5 4′ 6′ 100 100 7′ 21′ 100 100 6 3′ 5′ 100 100 12′ 22′ 100 100 7 4′ 5′ 100 100 15′ 24′ 100 100 8 hours 8 4′ 5′ 100 100 7′ 18 100 100 2 days 0 53′ 1 h 21′ 100 1 h 02′ 1 h 34′ 100 1 29′ 1 h 02′ 100 1 h 04′ 2 h 20′ 100 2 21′ 35′ 100 1 h 03′ 1 h 30′ 100 3 13′ 23′ 100 44′ 1 h 35′ 100 4 14′ 24′ 100 37 1 h 12′ 100 5 7′ 13′ 100 35′ 1 h 14′ 100 6 9′ 20′ 100 23′ 40′ 100 7 7′ 13′ 100 26′ 45′ 100 16 hours 8 5′ 8′ 100 9′ 14′ 100 7 days 0 41′ 52′ 100 100 1 h 10′ 1 h 34′ 100 100 1 24′ 42′ 100 100 39′ 1 h 24′ 100 100 2 8′ 14′ 100 100 34′ 1 h 03′ 100 100 3 8′ 16′ 100 100 15′ 54′ 100 100 4 7′ 15′ 100 100 18′ 30′ 100 100 5 8′ 17′ 100 100 24′ 41′ 100 100 6 8′ 16′ 100 100 19′ 31′ 100 100 7 7′ 14′ 100 100 16′ 44′ 100 100 56 hours 8 6′ 11′ 100 100 7′ 12′ 100 100 13 days 0 30′ 43′ 100 100 29′ 48′ 100 100 1 6′ 11′ 100 100 8′ 13′ 100 100 2 4′ 8′ 100 100 6′ 10′ 100 100 3 3′ 4′ 100 100 4′ 9′ 100 100 4 2′ 5′ 100 100 4′ 8′ 100 100 5 3′ 6′ 100 100 7′ 22′ 100 100 6 2′ 6′ 100 100 6′ 12′ 100 100 7 2′ 7′ 100 100 5′ 8′ 100 100 104 hours 8 2′ 6′ 100 100 5′ 8′ 100 100 20 days 0 42′ 57′ 100 100 38′ 55′ 100 100 1 5′ 11′ 100 100 3′ 7′ 100 100 2 5′ 11′ 100 100 2′ 6′ 100 100 3 4′ 8′ 100 100 2′ 4′ 100 100 4 5′ 7′ 100 100 2′ 4′ 100 100 5 6′ 9′ 100 100 2′ 6′ 100 100 6 5′ 8′ 100 100 2′ 5′ 100 100 7 4′ 8′ 100 100 2′ 7′ 100 100 160 hours 8 5′ 7′ 100 100 2′ 6′ 100 100 27 days 0 1 h 28′ 1 h 53′ 100 100 42′ 52′ 100 100 1 1 h 13′ 2 h 05′ 100 100 35′ 49′ 100 100 2 1 h 01′ 1 h 35′ 100 100 10′ 50′ 100 100 3 40′ 1 h 13′ 100 100 7′ 14′ 100 100 4 23′ 43′ 100 100 7′ 12′ 100 100 5 33′ 53′ 100 100 8′ 15′ 100 100 6 8′ 18′ 100 100 4′ 8′ 100 100 7 20′ 58′ 100 100 3′ 5′ 100 100 216 hours 8 7′ 11′ 100 100 3′ 5′ 100 100 35 days 0 1 h 25′ 2 h 20′ 100 100 1 h 00′ 1 h 13′ 100 100 1 43′ 1 h 15′ 100 100 11′ 43′ 100 100 2 28′ 1 h 03′ 100 100 5′ 10′ 100 100 3 43′ 1 h 03′ 100 100 3′ 7′ 100 100 4 13′ 1 h 18′ 100 100 3′ 7′ 100 100 5 15′ 58′ 100 100 2′ 7′ 100 100 6 20′ 1 h 05′ 100 100 3′ 18′ 100 100 7 8′ 28′ 100 100 2′ 9′ 100 100 280 hours 8 10′ 48′ 100 100 2′ 7′ 100 100 42 days 0 2 h 23′ 3 h 05′ 100 100 53′ 1 h 28′ 100 100 1 2 h 43′ 3 h 15′ 100 100 1 h 05′ 1 h 45′ 100 100 2 1 h 43′ 2 h 48′ 100 100 53′ 1 h 35′ 100 100 3 1 h 53′ 3 h 50′ 100 100 1 h 00′ 1 h 55′ 100 100 4 1 h 20′ 2 h 28′ 100 100 48′ 1 h 25′ 100 100 5 45′ >4 h 98 100 33′ 48′ 100 100 6 38′ 1 h 28′ 100 100 12′ 55′ 100 100 7 48′ >2 h 90 100 14′ 48′ 100 100 336 hours 8 >1 h >1 h 45 100 6′ 10′ 100 100 48 days 0 1 h 42′ 2 h 40′ 100 1 h 40′ 2 h 20′ 100 1 2 h 45′ 3 h 50′ 100 1 h 30′ 2 h 15′ 100 2 1 h 43′ 2 h 55′ 100 1 h 00′ 2 h 18′ 100 3 1 h 45′ 2 h 48′ 100 1 h 03′ 2 h 05′ 100 4 1 h 23′ 2 h 13′ 100 53′ 1 h 48′ 100 5 1 h 48′ >4 h 95 40′ 1 h 45′ 100 6 1 h 20′ >3 h 88 35′ 1 h 00′ 100 7 39′ >2 h 90 9′ 48′ 100 384 hours 8 >1 h >1 h 60 8′ >1 h 90 - Based on the present results, the biological activity of the formulations mentioned here in sufficient.
Claims (5)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19731156 | 1997-07-21 | ||
DE19731156.3 | 1997-07-21 | ||
DE19731156A DE19731156A1 (en) | 1997-07-21 | 1997-07-21 | Improved gel formulations containing insecticide |
PCT/EP1998/004253 WO1999004629A1 (en) | 1997-07-21 | 1998-07-08 | Improved gel formulations containing insecticide |
Publications (2)
Publication Number | Publication Date |
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US20010055604A1 true US20010055604A1 (en) | 2001-12-27 |
US6447795B2 US6447795B2 (en) | 2002-09-10 |
Family
ID=7836332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US09/462,958 Expired - Fee Related US6447795B2 (en) | 1997-07-21 | 1998-07-08 | Gel formulations containing insecticide |
Country Status (11)
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US (1) | US6447795B2 (en) |
EP (1) | EP0999743B1 (en) |
JP (1) | JP2001515840A (en) |
CN (1) | CN1265005A (en) |
AT (1) | ATE225603T1 (en) |
AU (1) | AU739899B2 (en) |
BR (1) | BR9810725B1 (en) |
DE (2) | DE19731156A1 (en) |
ES (1) | ES2185201T3 (en) |
ID (1) | ID24646A (en) |
WO (1) | WO1999004629A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7215878B2 (en) | 2000-01-13 | 2007-05-08 | S.C. Johnson & Son, Inc. | Chip that comprises an active agent and an integrated heating element |
US20100160396A1 (en) * | 2007-05-25 | 2010-06-24 | Bayer Scropscience Ag | Insecticidal Compositions of 2-Cyanobenzene Sulfonamide Compounds and Isomeric Forms Thereof Having Improved Effect |
US8231887B2 (en) | 2008-04-11 | 2012-07-31 | Basf Corporation | Pesticidal compositions |
US9549546B2 (en) | 2011-12-09 | 2017-01-24 | Shin-Etsu Chemical Co., Ltd. | Sustained release preparation comprising insect pest-targeting gel composition |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2002230389A1 (en) * | 2000-06-14 | 2002-04-29 | Vermeer Manufacturing Company | Utility mapping and data distribution system and method |
US20030040504A1 (en) * | 2001-05-09 | 2003-02-27 | Gans Eugene H. | Ectoparasiticidal compositions and methods of their use |
US6722578B2 (en) * | 2002-03-11 | 2004-04-20 | S.C. Johnson & Son, Inc. | Apparatus for dispensing volatile materials |
US7813224B2 (en) * | 2006-04-06 | 2010-10-12 | Underground Imaging Technologies, Inc. | Seismic source/receiver probe for shallow seismic surveying |
US9646415B2 (en) * | 2006-05-16 | 2017-05-09 | Underground Imaging Technologies, Inc. | System and method for visualizing multiple-sensor subsurface imaging data |
US8089390B2 (en) * | 2006-05-16 | 2012-01-03 | Underground Imaging Technologies, Inc. | Sensor cart positioning system and method |
DE102008006883A1 (en) * | 2008-01-31 | 2009-08-13 | Evonik Degussa Gmbh | Silica dispersion |
CN108056119A (en) * | 2018-01-19 | 2018-05-22 | 山东省寄生虫病防治研究所 | A kind of mosquito-fly pesticide |
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JPS53121927A (en) * | 1977-03-29 | 1978-10-24 | Sumitomo Chem Co Ltd | Insecticidal composition for electiric mosquito-repellent device |
JPS54135227A (en) * | 1978-04-13 | 1979-10-20 | Kureha Chem Ind Co Ltd | Insecticidal or fungicidal fumigant |
IN152745B (en) * | 1980-03-21 | 1984-03-24 | Airwick Ag | |
GR82163B (en) | 1984-01-31 | 1984-12-13 | Earth Chemical Co | |
EG18025A (en) | 1986-07-18 | 1993-06-30 | Sumitomo Chemical Co | A method for killing insects by heating fumigation |
DE69407949T2 (en) * | 1993-10-01 | 1998-05-14 | Scherer Corp R P | COMPOSITIONS FOR DISTRIBUTING FRAGRANCES |
DE4424786A1 (en) | 1994-07-14 | 1996-01-18 | Bayer Ag | Insecticide-containing gel formulations for evaporator systems |
-
1997
- 1997-07-21 DE DE19731156A patent/DE19731156A1/en not_active Withdrawn
-
1998
- 1998-07-08 CN CN98807510A patent/CN1265005A/en active Pending
- 1998-07-08 AU AU88592/98A patent/AU739899B2/en not_active Ceased
- 1998-07-08 WO PCT/EP1998/004253 patent/WO1999004629A1/en active IP Right Grant
- 1998-07-08 JP JP2000503709A patent/JP2001515840A/en active Pending
- 1998-07-08 ID IDW20000017D patent/ID24646A/en unknown
- 1998-07-08 DE DE59805910T patent/DE59805910D1/en not_active Expired - Fee Related
- 1998-07-08 US US09/462,958 patent/US6447795B2/en not_active Expired - Fee Related
- 1998-07-08 EP EP98940186A patent/EP0999743B1/en not_active Expired - Lifetime
- 1998-07-08 ES ES98940186T patent/ES2185201T3/en not_active Expired - Lifetime
- 1998-07-08 BR BRPI9810725-9A patent/BR9810725B1/en not_active IP Right Cessation
- 1998-07-08 AT AT98940186T patent/ATE225603T1/en not_active IP Right Cessation
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7215878B2 (en) | 2000-01-13 | 2007-05-08 | S.C. Johnson & Son, Inc. | Chip that comprises an active agent and an integrated heating element |
US20100160396A1 (en) * | 2007-05-25 | 2010-06-24 | Bayer Scropscience Ag | Insecticidal Compositions of 2-Cyanobenzene Sulfonamide Compounds and Isomeric Forms Thereof Having Improved Effect |
US8604068B2 (en) * | 2007-05-25 | 2013-12-10 | Bayer Cropscience Ag | Insecticidal compositions of 2-cyanobenzene sulfonamide compounds and isomeric forms thereof having improved effect |
US8231887B2 (en) | 2008-04-11 | 2012-07-31 | Basf Corporation | Pesticidal compositions |
US8591927B2 (en) | 2008-04-11 | 2013-11-26 | Basf Corporation | Pesticidal compositions |
US9005644B2 (en) | 2008-04-11 | 2015-04-14 | Basf Corporation | Pesticidal compositions |
US9549546B2 (en) | 2011-12-09 | 2017-01-24 | Shin-Etsu Chemical Co., Ltd. | Sustained release preparation comprising insect pest-targeting gel composition |
US10244750B2 (en) | 2011-12-09 | 2019-04-02 | Shin-Etsu Chemical Co., Ltd. | Insect pest-targeting gel composition and sustained release preparation comprising that |
Also Published As
Publication number | Publication date |
---|---|
AU8859298A (en) | 1999-02-16 |
BR9810725A (en) | 2000-08-08 |
WO1999004629A1 (en) | 1999-02-04 |
ES2185201T3 (en) | 2003-04-16 |
ID24646A (en) | 2000-07-27 |
DE19731156A1 (en) | 1999-01-28 |
US6447795B2 (en) | 2002-09-10 |
EP0999743B1 (en) | 2002-10-09 |
DE59805910D1 (en) | 2002-11-14 |
EP0999743A1 (en) | 2000-05-17 |
ATE225603T1 (en) | 2002-10-15 |
JP2001515840A (en) | 2001-09-25 |
BR9810725B1 (en) | 2010-09-21 |
CN1265005A (en) | 2000-08-30 |
AU739899B2 (en) | 2001-10-25 |
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