US20010039431A1 - Device and method for selectively removing a thrombus filter - Google Patents

Device and method for selectively removing a thrombus filter Download PDF

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US20010039431A1
US20010039431A1 US09/904,259 US90425901A US2001039431A1 US 20010039431 A1 US20010039431 A1 US 20010039431A1 US 90425901 A US90425901 A US 90425901A US 2001039431 A1 US2001039431 A1 US 2001039431A1
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Prior art keywords
thrombus filter
strut
struts
patient
thrombus
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Granted
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US09/904,259
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US6416530B2 (en
Inventor
Robert DeVries
Hannah Kim
Naroun Soun
Forrest Whitcher
Mark Wolfson
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Lifescreen Sciences LLC
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Scimed Life Systems Inc
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Assigned to ACACIA RESEARCH GROUP LLC reassignment ACACIA RESEARCH GROUP LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BOSTON SCIENTIFIC SCIMED, INC.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/011Instruments for their placement or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/0105Open ended, i.e. legs gathered only at one side
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2002/016Filters implantable into blood vessels made from wire-like elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028Shapes in the form of latin or greek characters
    • A61F2230/005Rosette-shaped, e.g. star-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0067Three-dimensional shapes conical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0071Additional features; Implant or prostheses properties not otherwise provided for breakable or frangible

Definitions

  • the present invention relates generally to filters for use inside blood vessels. More particularly, the present invention relates to thrombus filters which can be securely affixed at a selected location in the vascular system and removed when no longer required.
  • DVT Deep Venous Thrombosis
  • Pulmonary embolization can frequently be fatal, for example when a large blood clot interferes with the life-sustaining pumping action of the heart. If a blood clot passes through the heart it will be pumped into the lungs and may cause a blockage in the pulmonary arteries. A blockage of this type in the lungs will interfere with the oxygenation of the blood causing shock or death.
  • Pulmonary embolization may be successfully prevented by the appropriate placement of a thrombus filter in the vascular system of a patient's body. Placement of the filter may be accomplished by performing a laparotomy with the patient under general anesthesia. However, intravenous insertion is often the preferred method of placing a thrombus filter in a patient's vascular system.
  • Intravenous insertion of a thrombus filter is less invasive and it requires only a local anesthetic.
  • the thrombus filter is collapsed within a delivery catheter.
  • the delivery catheter is introduced into the patients vascular system at a point which is convenient to the physician.
  • the delivery catheter is then fed further into the vascular system until it reaches a desirable location for filter placement.
  • the thrombus filter is then released into the blood vessel from the delivery catheter.
  • a thrombus filter is placed in the inferior vena cava of a patient.
  • the inferior vena cava is a large vessel which returns blood to the heart from the lower part of the body.
  • the inferior vena cava may be accessed through the patient's femoral vein.
  • Thrombus filters may be placed in other locations when treating other conditions. For example, if blood clots are expected to approach the heart and lungs from the upper portion of the body, a thrombus filter may be positioned in the superior-vena cava.
  • the superior vena cava is a large vessel which returns blood to the heart from the upper part of the body.
  • the superior vena cava may by accessed through the jugular vein, located in the patient's neck.
  • a thrombus filter acts to catch and hold blood clots.
  • the flow of blood around the captured clots allows the body's lysing process to dissolve the clots.
  • the walls of the blood vessels are lined with a thin inner membrane or intima.
  • the anchor portions of a thrombus filter puncture this inner membrane the body responds in a process referred to as neointimal hyperplasia.
  • the punctured area of inner membrane is overgrown with a number of new cells.
  • the anchor portions of the thrombus filter are encapsulated with new cell growth (neointimal hyperplasia).
  • thrombus filters placed in the blood vessel of a patient become affixed in the blood vessel walls within two weeks after being implanted. Because the portions of the filter contacting the blood vessel wall become fixed in this way, many prior art filters cannot be removed percutaneously after being in place for more than two weeks.
  • the present invention pertains to a thrombus filter and a method of removing a thrombus filter using minimally invasive methods while limiting complications due to neointimal encapsulation of the anchor portions of the thrombus filter.
  • a thrombus filter for use with the inventive removal method includes a body member and a plurality of elongated struts. Each strut has a joined end and a free end. The joined end of each strut is fixably attached to the body member on the thrombus filter. The struts radiate outwardly from the body member of the thrombus filter such that the thrombus filter is generally conical in shape.
  • a thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, struts, and anchor members.
  • the insulation layer includes an opening.
  • the opening in the insulation layer is proximate a sacrificial link. The opening in the insulation layer allows direct contact between a portion of the thrombus filter and the patient's blood. This direct contact creates a conductor path between the thrombus filter and the body of the patient.
  • a first electrical conductor forms an electrical connection with the body portion of the thrombus filter.
  • a second electrical connector forms an electrical connection with the patient's body.
  • a power supply is used to selectively apply a voltage differential between the body portion of the thrombus filter and the body of a patient. This voltage differential induces a current through the thrombus filter.
  • the free ends of the struts engage the blood vessel wall.
  • the body member of the thrombus filter is held in a position proximate the center of the blood vessel by the plurality of struts which engage the blood vessel walls with opposing force vectors.
  • the conical formation of struts acts to trap or capture blood clots.
  • the generally conical shape of the formation of struts serves to urge captured blood clots toward the center of the blood flow. The flow of blood around the captured blood clots allows the body's natural lysing process to dissolve the clots.
  • anchor members may be attached to the free ends of the struts.
  • anchors are attached by a sleeve.
  • anchor members are attached by a sacrificial link.
  • the anchors are formed from the strut itself.
  • the thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, the struts and the anchor members. An opening in the insulation layer is selectively created over a portion of the thrombus filter which retains anchors to the free ends of the struts. This opening in the insulating layer allows direct contact between the material of the thrombus filter and the patient's blood. This direct contact creates a conductive path between a portion of the thrombus filter and the patient's blood.
  • a removal catheter with a lumen and a distal end is disposed in the lumen of the blood vessel.
  • the removal catheter enters the patient's vascular system at a point which is readily accessible to the physician. Once in the vascular system, the catheter is urged forward until the distal end of the removal catheter is proximate the thrombus filter.
  • a first electrical conductor is disposed inside the lumen of the removal catheter.
  • the first electrical conductor includes a proximal end and a distal end. The distal end of the first electrical connector penetrates the insulating layer on the thrombus filter to form an electrical connection with the body portion of the thrombus filter.
  • the proximal end of the first electrical conductor is electrically connected to a power supply.
  • a proximal end of the second electrical conductor is also electrically connected to the power supply.
  • the distal end of the second electrical conductor is electrically connected to the body of the patient.
  • the power supply is used to selectively apply a voltage differential between the first electrical conductor and the second electrical conductor.
  • This voltage differential induces a current flow between the thrombus filter and the blood of the patient. Because the thrombus filter is covered with an insulating layer, this current must flow through the area proximate the opening in the insulating layer. The flow of current causes electrolytic corrosion of the thrombus filter in the selected area. The flow of electrical current between the thrombus filter and the patient's blood is continued until a selected portion of the thrombus filter has been weakened or cut completely free by electrolytic corrosion. The weakened link will separate when a load is applied, for example, by an elongated pulling tool.
  • the thrombus filter may be pulled into the lumen of the retrieval catheter leaving the anchor portions attached to the blood vessel wall. Pulling the thrombus filter into the lumen of the retrieval catheter causes the struts to collapse. When the struts collapse, the thrombus filter is transformed from a generally conical shape to a generally cylindrical shape. Pulling of the thrombus filter into the lumen of the retrieval catheter may be accomplished with a retrieval wire including a hook.
  • the anchor members remain fixed in the walls of the blood vessel by encapsulating cell growth due to neointimal hyperplasia. When the thrombus filter is pulled into the lumen of the retrieval catheter, the removal of the thrombus filter from the patient becomes simply a matter of withdrawing the removal catheter from the lumen of the blood vessel.
  • FIG. 1 is a perspective view of a thrombus filter
  • FIG. 2 is a plan view of a portion of the thrombus filter including an anchor portion and a weakened strut portion;
  • FIG. 3 is a plan view of a portion of a thrombus filter including an anchor portion and a weakened strut portion;
  • FIG. 5 is a plan view of a portion of a thrombus filter illustrating attachment of an anchor portion to a strut portion;
  • FIG. 6 is a schematic representation of the removal of a thrombus filter from a blood vessel
  • FIG. 7 is a schematic illustration of a thrombus filter which has been pulled into the lumen of a retrieval catheter.
  • FIG. 8 is a plan view of a portion of the thrombus filter.
  • FIG. 1 is a perspective view of a thrombus filter 20 .
  • Thrombus filter 20 includes a body member 22 and a plurality of elongated struts 24 .
  • Struts 24 each have a joined end 26 and a free end 28 .
  • Joined end 26 of each strut 24 is fixedly attached to body member 22 .
  • body member 22 is generally cylindrical in shape, and includes a bore 23 . It should be understood that other embodiments of body member 22 are possible without departing from the spirit or scope of the present invention.
  • Struts 24 radiate outwardly from body member 22 such that thrombus filter 20 is generally conical in shape.
  • free ends 28 engage the blood vessel wall.
  • Body member 22 is held in a position proximate to the center of the blood vessel by the plurality of struts 24 which engage the blood vessel walls with opposing force vectors.
  • thrombus filter 20 When thrombus filter 20 is disposed in a blood vessel, the conical formation of struts 24 acts to trap, or capture blood clots.
  • the generally conical shape of the formation of struts 24 serves to urge captured blood clots toward the center of the blood flow. The flow of blood around the captured blood clots allows the body's natural lysing process to dissolve the clots.
  • anchor members may be attached to free ends 28 of struts 24 .
  • FIG. 2 illustrates one embodiment of an anchor member 30 including a stem 32 and a sharp projection 34 .
  • Stem 32 of anchor member 30 is attached to strut 24 with a sleeve 36 .
  • sleeve 36 is fixedly attached to free end 28 of strut 24 with a weld joint 38 .
  • Other methods of attachment may be used without departing from the spirit or scope of this invention.
  • sleeve 36 may be fixedly attached to free end 28 of strut 24 through soldering, brazing, crimping, or swaging.
  • Sleeve 36 could also be attached to strut 24 with a fastening means such as a suture.
  • sleeve 36 could be bonded to strut 24 with a permanent adhesive.
  • Stem 32 is adapted to releasably mate with sleeve 36 .
  • the method of connecting stem 32 to sleeve 36 is selected so that the mechanical strength of the connection between sleeve 36 and stem 32 will be less than the mechanical strength of the connection between sleeve 36 and strut 24 .
  • the outer diameter of stem 32 and the inside diameter of sleeve 36 may be selected to form an interference fit.
  • an adhesive may be used to attach stem 32 to sleeve 36 , this adhesive would be selected so that the connection between stem 32 and sleeve 36 would be weaker than the connection between strut 24 and sleeve 36 .
  • thrombus filter 20 When thrombus filter 20 is removed from the body an extraction catheter including an elongated pulling tool is used to exert a pulling force on thrombus filter 20 . Thrombus filter 20 is pulled with a force which is sufficient to separate stem 32 from sleeve 36 . Thereby removing thrombus filter 20 from the blood vessel, but leaving anchor members 30 attached to the blood vessel wall.
  • FIG. 3 illustrates an alternate embodiment of the present invention.
  • An anchor member 30 includes a stem 32 and a sharp projection 34 .
  • Stem 32 of anchor member 30 is attached to free end 28 of strut 24 with a sacrificial link 40 which is comprised of a material which is susceptible to electrolytic disintegration/weakening in blood.
  • Sacrificial link 40 includes a first bore 42 and a second bore 44 .
  • a first interference fit is formed between stem 32 of anchor member 30 and first bore 42 of sacrificial link 40 .
  • a second interference fit may also be formed between free end 28 of strut 24 and second bore 44 of sacrificial link 40 .
  • free end 28 of strut 24 may be attached to sacrificial link 40 using other methods.
  • sacrificial link 40 may be fixedly attached to free end 28 of strut 24 through soldering, brazing, crimping, or swaging. Sacrificial link could also be attached to strut 24 with a fastening means such as a suture.
  • sacrificial link 40 could be bonded to strut 24 with an adhesive.
  • thrombus filter 20 can be formed from the struts 24 shown in FIG. 3 as an alternative to those shown in FIG. 2.
  • This alternative embodiment of thrombus filter 20 can include an insulating layer 39 substantially covering thrombus filter 20 including body portion 22 , struts 24 , and anchor members 30 (thrombus filter 20 and body portion 22 not shown in FIG. 3).
  • insulating layer 39 is shown covering strut 24 , anchor member 30 , and a portion of sacrificial link 40 .
  • Insulation layer 39 includes an opening 41 proximate sacrificial link 40 . Opening 41 of insulating layer 39 allows direct contact between sacrificial link 40 and the patients blood. This direct contact creates a conductive path between sacrificial link 40 and the body of the patient. The significance of this conductive path will be described below.
  • parylene Another material which may be used to fabricate insulating layer 39 is a thermoplastic generically known as parylene.
  • parylene There are a variety of polymers based on para-xylylene. These polymers are typically placed onto a substrate by vapor phase polymerization of the monomer. Parylene N coatings are produced by vaporization of a di(P-xylylene)dimer, pyrollization, and condensation of the vapor to produce a polymer that is maintained at comparatively lower temperature.
  • parylene-C is derived from di(monochloro-P-xylylene)
  • parylene-D is derived from di(dichloro-P-xylylene).
  • thrombus filter 20 can be formed from the struts 24 shown in FIG. 4 as an alternative to those shown in FIG. 2.
  • This alternative embodiment of thrombus filter 20 can include an insulating layer 39 substantially covering thrombus filter 20 including body portion 22 , struts 24 , and anchor members 30 (thrombus filter 20 and body portion 22 not shown in FIG. 4)
  • insulating layer 39 is shown covering strut 24 , anchor member 30 , and a portion of sacrificial link 50 .
  • Insulation layer 39 includes opening 51 proximate sacrificial link 50 . Opening 51 of insulating layer 39 allows direct contact between sacrificial link 50 and the patient's body. Specifically, blood and tissue of the patients body is free to contact sacrificial link 50 . This direct contact creates a conductive path between sacrificial link 50 and the body of the patient.
  • thrombus filter 20 can be formed from the struts 24 shown in FIG. 5 as an alternative to those shown in FIG. 2.
  • This alternative embodiment of thrombus filter 20 can include an insulating layer 39 substantially covering thrombus filter 20 including body portion 22 , struts 24 , and anchor members 30 (thrombus filter 20 and body portion 22 not shown in FIG. 5)
  • insulating layer 39 is shown covering strut 24 , anchor member 30 , and a portion of sacrificial link 60 .
  • Insulation layer 39 includes opening 61 proximate sacrificial link 60 . Opening 61 of insulating layer 39 allows direct contact between sacrificial link 60 and the patient's blood. This direct contact creates a conductive path between sacrificial link 60 and the body of the patient. The significance of this conductive path is described in the following paragraph.
  • Blood vessel 100 includes walls 104 having a thin inner membrane or intima 106 .
  • Anchors 30 have punctured inner membrane 106 and are embedded in walls 104 of blood vessel 100 .
  • the body responds to the puncturing of inner membrane 106 with a process referred to as neointimal hyperplasia.
  • the punctured area of inner membrane 106 is overgrown with a multitude of new cells. In FIG. 6, these new cells are illustrated as encapsulating cell growth 108 .
  • anchors 30 will be completely encapsulated by encapsulating cell growth 108 . With many prior art thrombus filters, removal of the filter after neointimal hyperplasia encapsulation has occurred is very difficult, if not impossible.
  • a preferred embodiment of the thrombus filter in accordance with the present invention can be removed using minimally invasive methods without complications due to neointimal hyperplasia of anchors 30 .
  • a minimally invasive process which may be used to remove thrombus filter 20 from blood vessel 100 is schematically represented in FIG. 6.
  • a removal catheter 110 with a lumen 112 and a distal end 114 is disposed in lumen 102 of blood vessel 100 .
  • Removal catheter 110 enters the patients vascular system at a point which is readily accessible to the physician. Once in the vascular system, catheter 110 is urged forward until distal end 114 is proximate to the thrombus filter 20 .
  • a number of methods suitable for forming the electrical connection between first electrical connector 114 and body portion 22 of thrombus filter 20 are known in the art.
  • a needle electrode could be disposed at distal end 118 of electrical connector 114 .
  • the needle electrode could penetrate insulating layer 39 and make electrical contact with body portion 22 of thrombus filter 20 .
  • An easily deformed material such as silicone rubber or silicone foam rubber could be disposed around the needle electrode to insulate the electrical connection.
  • Power supply 120 is used to selectively apply a voltage differential between first electrical conductor 114 and second electrical conductor 124 .
  • This voltage differential induces a current flow 200 through sacrificial links 60 (links 40 and 50 could be sacrificed in this manner as well).
  • the path which current flow 200 takes through the body of the patient is represented by a dashed link.
  • Current flow 200 causes sacrificial links 60 to corrode, dissolve, or disintegrate until the bond between free end 28 of strut 24 and stem 32 of anchor 30 are broken or weakened.
  • thrombus filter 20 may be pulled into lumen 112 of retrieval catheter 110 .
  • FIG. 7 is a schematic representation of thrombus filter 20 after it has been pulled into lumen 112 of retrieval catheter 110 .
  • pulling thrombus filter 20 into lumen 112 of retrieval catheter 110 causes struts 24 to collapse.
  • struts 24 collapse thrombus filter 20 is transformed from a generally conical shape to a generally cylindrical shape.
  • the pulling of thrombus filter 20 into lumen 112 of retrieval catheter 110 may be accomplished with a retrieval wire 140 including a hook 142 .
  • anchor members 30 remain fixed in the walls of blood vessel 100 by encapsulating cell growth 108 .
  • the removal of thrombus filter 20 from the patient becomes a simple matter of withdrawing removal catheter 110 from lumen 102 of blood vessel 100 .
  • FIG. 8 may be removed using a process similar to that shown in FIG. 6.
  • a first electrical conductor forms an electrical connection with the body portion of the thrombus filter.
  • a second electrical conductor forms an electrical connection with the patient's body. This connection may be via an electrode placed on the patient's skin as shown in FIG. 6. It should be understood that the electrical connection to the patient's body may be accomplished using other methods without departing from the spirit or scope of the invention. For example, the connection to the patients body may be made through an electrode disposed on the retrieval catheter which makes direct contact with the patient's blood.
  • a power supply is used to selectively apply a voltage differential between the body portion of the thrombus filter and body of the patient. This voltage differential induces a current flow through the thrombus filter. In the embodiment of FIG. 8, current flows between strut 24 and opening 82 in insulating layer 39 .
  • the flow of electrical current between strut 24 and the patients blood causes the electrolytic corrosion of strut 24 in an area proximate opening 82 in insulating layer 39 .
  • the current flow is continued until strut 24 has been weakened or cut through by electrolytic corrosion.
  • the cross sectional area of strut 24 may be reduced proximate opening 82 in insulating layer 39 .
  • thrombus filter 20 may be pulled into a retrieval catheter.

Abstract

A thrombus filter which can be securely fixed in a selected location in the vascular system of a patient and removed when no longer required. The thrombus filter includes a plurality of struts which radiate from a body portion to form the generally conical shape of the thrombus filter. The thrombus filter includes anchor members joined to the free end of each strut. The thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, the struts and the anchor members. The insulating layer includes an opening proximate the anchor members. The opening in the insulating layer creates a conductive path between the thrombus filter and the patient's body. When removal of the thrombus filter is desired, a first electrical conductor forms an electrical connection with the body portion of the thrombus filter. A second electrical conductor forms an electrical connection with the patient's body. A power supply is used to selectively apply a voltage differential between the thrombus filter and the body of the patient. This voltage differential induces an electrical current the flow of electrical current between the thrombus filter and the patient's blood causes the electrolytic corrosion of the thrombus filter proximate the opening in the insulating layer. When the bond between the struts of the thrombus filter and the anchors is cut through or weakened, the thrombus filter may be pulled into the lumen of a retrieval catheter. Removal of the thrombus filter from the patient's body is completed by withdrawing the retrieval catheter from the patient's blood vessel.

Description

    FIELD OF THE INVENTION
  • The present invention relates generally to filters for use inside blood vessels. More particularly, the present invention relates to thrombus filters which can be securely affixed at a selected location in the vascular system and removed when no longer required. [0001]
  • BACKGROUND OF THE INVENTION
  • There are a number of situations in the practice of medicine when it becomes desirable for a physician to place a filter in the vascular system of a patient. One of the most common applications for vascular filters is the treatment of Deep Venous Thrombosis (DVT). Deep Venous Thrombosis patients experience clotting of blood in the large veins of the lower portions of the body. These patients are constantly at risk of a clot breaking free and traveling via the inferior vena cava to the heart and lungs. This process is known as pulmonary embolization. Pulmonary embolization can frequently be fatal, for example when a large blood clot interferes with the life-sustaining pumping action of the heart. If a blood clot passes through the heart it will be pumped into the lungs and may cause a blockage in the pulmonary arteries. A blockage of this type in the lungs will interfere with the oxygenation of the blood causing shock or death. [0002]
  • Pulmonary embolization may be successfully prevented by the appropriate placement of a thrombus filter in the vascular system of a patient's body. Placement of the filter may be accomplished by performing a laparotomy with the patient under general anesthesia. However, intravenous insertion is often the preferred method of placing a thrombus filter in a patient's vascular system. [0003]
  • Intravenous insertion of a thrombus filter is less invasive and it requires only a local anesthetic. In this procedure, the thrombus filter is collapsed within a delivery catheter. The delivery catheter is introduced into the patients vascular system at a point which is convenient to the physician. The delivery catheter is then fed further into the vascular system until it reaches a desirable location for filter placement. The thrombus filter is then released into the blood vessel from the delivery catheter. [0004]
  • In the treatment of Deep Venous Thrombosis, a thrombus filter is placed in the inferior vena cava of a patient. The inferior vena cava is a large vessel which returns blood to the heart from the lower part of the body. The inferior vena cava may be accessed through the patient's femoral vein. [0005]
  • Thrombus filters may be placed in other locations when treating other conditions. For example, if blood clots are expected to approach the heart and lungs from the upper portion of the body, a thrombus filter may be positioned in the superior-vena cava. The superior vena cava is a large vessel which returns blood to the heart from the upper part of the body. The superior vena cava may by accessed through the jugular vein, located in the patient's neck. [0006]
  • Once placed inside a blood vessel, a thrombus filter acts to catch and hold blood clots. The flow of blood around the captured clots allows the body's lysing process to dissolve the clots. [0007]
  • The walls of the blood vessels are lined with a thin inner membrane or intima. When the anchor portions of a thrombus filter puncture this inner membrane the body responds in a process referred to as neointimal hyperplasia. As a result, the punctured area of inner membrane is overgrown with a number of new cells. The anchor portions of the thrombus filter are encapsulated with new cell growth (neointimal hyperplasia). [0008]
  • Due to neointimal hyperplasia, thrombus filters placed in the blood vessel of a patient become affixed in the blood vessel walls within two weeks after being implanted. Because the portions of the filter contacting the blood vessel wall become fixed in this way, many prior art filters cannot be removed percutaneously after being in place for more than two weeks. [0009]
  • SUMMARY OF THE INVENTION
  • The present invention pertains to a thrombus filter and a method of removing a thrombus filter using minimally invasive methods while limiting complications due to neointimal encapsulation of the anchor portions of the thrombus filter. A thrombus filter for use with the inventive removal method includes a body member and a plurality of elongated struts. Each strut has a joined end and a free end. The joined end of each strut is fixably attached to the body member on the thrombus filter. The struts radiate outwardly from the body member of the thrombus filter such that the thrombus filter is generally conical in shape. A thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, struts, and anchor members. The insulation layer includes an opening. In one embodiment of the current invention, the opening in the insulation layer is proximate a sacrificial link. The opening in the insulation layer allows direct contact between a portion of the thrombus filter and the patient's blood. This direct contact creates a conductor path between the thrombus filter and the body of the patient. [0010]
  • When removal of a thrombus filter is desired, a first electrical conductor forms an electrical connection with the body portion of the thrombus filter. A second electrical connector forms an electrical connection with the patient's body. A power supply is used to selectively apply a voltage differential between the body portion of the thrombus filter and the body of a patient. This voltage differential induces a current through the thrombus filter. [0011]
  • When a voltage differential is applied between the body portion of the thrombus filter and the body of a patient, current flows between the thrombus filter and the patient's blood at a location proximate the opening in the insulating layer. The flow of electrical current between the thrombus filter and the patient's blood causes electrolytic corrosion of the thrombus filter in a selected area. The current flow is continued until a selected area of the thrombus filter has been weakened or cut through by electrolytic corrosion. In one embodiment of the thrombus filter, electrolytic corrosion weakens or cuts through a sacrificial link holding an anchor to the thrombus filter. [0012]
  • When the thrombus filter is deployed inside a blood vessel, the free ends of the struts engage the blood vessel wall. The body member of the thrombus filter is held in a position proximate the center of the blood vessel by the plurality of struts which engage the blood vessel walls with opposing force vectors. The conical formation of struts acts to trap or capture blood clots. The generally conical shape of the formation of struts, serves to urge captured blood clots toward the center of the blood flow. The flow of blood around the captured blood clots allows the body's natural lysing process to dissolve the clots. [0013]
  • To assure firm attachment of the thrombus filter to the blood vessel, anchor members may be attached to the free ends of the struts. In one embodiment of the thrombus filter, anchors are attached by a sleeve. In a second embodiment of the thrombus filter, anchor members are attached by a sacrificial link. In a third embodiment of the thrombus filter, the anchors are formed from the strut itself. [0014]
  • When anchor members are attached by a sacrificial link, the material of the sacrificial link is selected to be one which is susceptible to electrolytic disintegration in blood. The thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, the struts and the anchor members. An opening in the insulation layer is selectively created over a portion of the thrombus filter which retains anchors to the free ends of the struts. This opening in the insulating layer allows direct contact between the material of the thrombus filter and the patient's blood. This direct contact creates a conductive path between a portion of the thrombus filter and the patient's blood. [0015]
  • When removal of the thrombus filter is desired, a removal catheter with a lumen and a distal end is disposed in the lumen of the blood vessel. The removal catheter enters the patient's vascular system at a point which is readily accessible to the physician. Once in the vascular system, the catheter is urged forward until the distal end of the removal catheter is proximate the thrombus filter. A first electrical conductor is disposed inside the lumen of the removal catheter. The first electrical conductor includes a proximal end and a distal end. The distal end of the first electrical connector penetrates the insulating layer on the thrombus filter to form an electrical connection with the body portion of the thrombus filter. The proximal end of the first electrical conductor is electrically connected to a power supply. A proximal end of the second electrical conductor is also electrically connected to the power supply. The distal end of the second electrical conductor is electrically connected to the body of the patient. [0016]
  • The power supply is used to selectively apply a voltage differential between the first electrical conductor and the second electrical conductor. This voltage differential induces a current flow between the thrombus filter and the blood of the patient. Because the thrombus filter is covered with an insulating layer, this current must flow through the area proximate the opening in the insulating layer. The flow of current causes electrolytic corrosion of the thrombus filter in the selected area. The flow of electrical current between the thrombus filter and the patient's blood is continued until a selected portion of the thrombus filter has been weakened or cut completely free by electrolytic corrosion. The weakened link will separate when a load is applied, for example, by an elongated pulling tool. [0017]
  • When the anchor portions of the thrombus filter are separated in this fashion, the thrombus filter may be pulled into the lumen of the retrieval catheter leaving the anchor portions attached to the blood vessel wall. Pulling the thrombus filter into the lumen of the retrieval catheter causes the struts to collapse. When the struts collapse, the thrombus filter is transformed from a generally conical shape to a generally cylindrical shape. Pulling of the thrombus filter into the lumen of the retrieval catheter may be accomplished with a retrieval wire including a hook. The anchor members remain fixed in the walls of the blood vessel by encapsulating cell growth due to neointimal hyperplasia. When the thrombus filter is pulled into the lumen of the retrieval catheter, the removal of the thrombus filter from the patient becomes simply a matter of withdrawing the removal catheter from the lumen of the blood vessel.[0018]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a perspective view of a thrombus filter; [0019]
  • FIG. 2 is a plan view of a portion of the thrombus filter including an anchor portion and a weakened strut portion; [0020]
  • FIG. 3 is a plan view of a portion of a thrombus filter including an anchor portion and a weakened strut portion; [0021]
  • FIG. 4 is a plan view of a portion of a thrombus filter including an anchor portion and a weakened strut portion; [0022]
  • FIG. 5 is a plan view of a portion of a thrombus filter illustrating attachment of an anchor portion to a strut portion; [0023]
  • FIG. 6 is a schematic representation of the removal of a thrombus filter from a blood vessel; [0024]
  • FIG. 7 is a schematic illustration of a thrombus filter which has been pulled into the lumen of a retrieval catheter; and [0025]
  • FIG. 8 is a plan view of a portion of the thrombus filter.[0026]
  • DETAILED DESCRIPTION OF THE INVENTION
  • FIG. 1 is a perspective view of a [0027] thrombus filter 20. Thrombus filter 20 includes a body member 22 and a plurality of elongated struts 24. Struts 24 each have a joined end 26 and a free end 28. Joined end 26 of each strut 24 is fixedly attached to body member 22.
  • [0028] Struts 24 may be fabricated from wire with a circular or rectangular cross section. For example, struts 24 may be comprised of 2 inch lengths of 0.018″ diameter wire. Stainless steel, titanium, and nickel-titanium alloys have all been found to be acceptable materials for struts 24. In the embodiment of FIG. 1, a plurality of bends 25 are disposed between free end 28 and fixed end 26 of each strut 24. It should be understood that struts 24 may also be straight, or include bends different than those illustrated in FIG. 1, without departing from the spirit or scope of the present invention.
  • In the embodiment of FIG. 1, [0029] body member 22 is generally cylindrical in shape, and includes a bore 23. It should be understood that other embodiments of body member 22 are possible without departing from the spirit or scope of the present invention.
  • [0030] Struts 24 radiate outwardly from body member 22 such that thrombus filter 20 is generally conical in shape. When thrombus filter 20 is deployed inside a blood vessel, free ends 28 engage the blood vessel wall. Body member 22 is held in a position proximate to the center of the blood vessel by the plurality of struts 24 which engage the blood vessel walls with opposing force vectors.
  • When [0031] thrombus filter 20 is disposed in a blood vessel, the conical formation of struts 24 acts to trap, or capture blood clots. The generally conical shape of the formation of struts 24 serves to urge captured blood clots toward the center of the blood flow. The flow of blood around the captured blood clots allows the body's natural lysing process to dissolve the clots.
  • To assure firm attachment of [0032] thrombus filter 20 to the blood vessel, anchor members may be attached to free ends 28 of struts 24. FIG. 2 illustrates one embodiment of an anchor member 30 including a stem 32 and a sharp projection 34. Stem 32 of anchor member 30 is attached to strut 24 with a sleeve 36.
  • In FIG. 2, [0033] sleeve 36 is fixedly attached to free end 28 of strut 24 with a weld joint 38. Other methods of attachment may be used without departing from the spirit or scope of this invention. For example, sleeve 36 may be fixedly attached to free end 28 of strut 24 through soldering, brazing, crimping, or swaging. Sleeve 36 could also be attached to strut 24 with a fastening means such as a suture. Finally, sleeve 36 could be bonded to strut 24 with a permanent adhesive.
  • [0034] Stem 32 is adapted to releasably mate with sleeve 36. The method of connecting stem 32 to sleeve 36 is selected so that the mechanical strength of the connection between sleeve 36 and stem 32 will be less than the mechanical strength of the connection between sleeve 36 and strut 24. Several methods of accomplishing this releasable connection have been contemplated. For example, the outer diameter of stem 32 and the inside diameter of sleeve 36 may be selected to form an interference fit. In another embodiment of the present invention, an adhesive may be used to attach stem 32 to sleeve 36, this adhesive would be selected so that the connection between stem 32 and sleeve 36 would be weaker than the connection between strut 24 and sleeve 36.
  • When [0035] thrombus filter 20 is removed from the body an extraction catheter including an elongated pulling tool is used to exert a pulling force on thrombus filter 20. Thrombus filter 20 is pulled with a force which is sufficient to separate stem 32 from sleeve 36. Thereby removing thrombus filter 20 from the blood vessel, but leaving anchor members 30 attached to the blood vessel wall.
  • FIG. 3 illustrates an alternate embodiment of the present invention. An [0036] anchor member 30 includes a stem 32 and a sharp projection 34. Stem 32 of anchor member 30 is attached to free end 28 of strut 24 with a sacrificial link 40 which is comprised of a material which is susceptible to electrolytic disintegration/weakening in blood. Sacrificial link 40 includes a first bore 42 and a second bore 44.
  • In the embodiment illustrated in FIG. 3, a first interference fit is formed between [0037] stem 32 of anchor member 30 and first bore 42 of sacrificial link 40. A second interference fit may also be formed between free end 28 of strut 24 and second bore 44 of sacrificial link 40. Alternately, free end 28 of strut 24 may be attached to sacrificial link 40 using other methods. For example, sacrificial link 40 may be fixedly attached to free end 28 of strut 24 through soldering, brazing, crimping, or swaging. Sacrificial link could also be attached to strut 24 with a fastening means such as a suture. Finally, sacrificial link 40 could be bonded to strut 24 with an adhesive.
  • In FIG. 3 it can be appreciated that [0038] thrombus filter 20 can be formed from the struts 24 shown in FIG. 3 as an alternative to those shown in FIG. 2. This alternative embodiment of thrombus filter 20 can include an insulating layer 39 substantially covering thrombus filter 20 including body portion 22, struts 24, and anchor members 30 (thrombus filter 20 and body portion 22 not shown in FIG. 3). In FIG. 3, insulating layer 39 is shown covering strut 24, anchor member 30, and a portion of sacrificial link 40. Insulation layer 39 includes an opening 41 proximate sacrificial link 40. Opening 41 of insulating layer 39 allows direct contact between sacrificial link 40 and the patients blood. This direct contact creates a conductive path between sacrificial link 40 and the body of the patient. The significance of this conductive path will be described below.
  • A number of materials are suitable for use in insulating [0039] layer 39, these materials include fluoropolytetrafluoroethylene (PTFE), polyethylene(PE), polypropylene (PP), polyvinylchloride (PVC), and polyurethane. A number of manufacturing processes may be used to create insulating layer 39. For example, a portion of insulating layer 39 may be made up of sections of shrink tubing. The shrink tubing sections may be positioned over the struts then shrunk by the application of heat. A spray process may also be used to apply insulating layer 39 to thrombus filter 20. For example, spraying PTFE solids in a suitable solvent carrier is a process which has been found suitable for this application.
  • Another material which may be used to fabricate insulating [0040] layer 39 is a thermoplastic generically known as parylene. There are a variety of polymers based on para-xylylene. These polymers are typically placed onto a substrate by vapor phase polymerization of the monomer. Parylene N coatings are produced by vaporization of a di(P-xylylene)dimer, pyrollization, and condensation of the vapor to produce a polymer that is maintained at comparatively lower temperature. In addition to parylene-N, parylene-C is derived from di(monochloro-P-xylylene) and parylene-D is derived from di(dichloro-P-xylylene). There are a variety of known ways to apply parylene to substrates. The use of paralene in surgical devices has been disclosed in U.S. Pat. No. 5,380,320 (to J. R. Morris), in U.S. Pat. No. 5,174,295 (to Christian et al.), and in U.S. Pat. No. 6,067,491 (to Taylor et al.).
  • FIG. 4 illustrates an additional embodiment of the present invention. In this embodiment, a [0041] distal end 52 of stem 32 is positioned adjacent to free end 28 of strut 24 in a butt joint configuration. Distal end 52 of stem 32 is fixedly joined to free end 28 of strut 24 with a sacrificial link 50. Sacrificial link 50 may be created using a process similar to brazing or soldering. The filler metal used in this process would be one selected because it is susceptible to electrolytic disintegration/weakening in blood.
  • In FIG. 4 it can be appreciated that [0042] thrombus filter 20 can be formed from the struts 24 shown in FIG. 4 as an alternative to those shown in FIG. 2. This alternative embodiment of thrombus filter 20 can include an insulating layer 39 substantially covering thrombus filter 20 including body portion 22, struts 24, and anchor members 30 (thrombus filter 20 and body portion 22 not shown in FIG. 4) In FIG. 4, insulating layer 39 is shown covering strut 24, anchor member 30, and a portion of sacrificial link 50. Insulation layer 39 includes opening 51 proximate sacrificial link 50. Opening 51 of insulating layer 39 allows direct contact between sacrificial link 50 and the patient's body. Specifically, blood and tissue of the patients body is free to contact sacrificial link 50. This direct contact creates a conductive path between sacrificial link 50 and the body of the patient.
  • FIG. 5 illustrates an additional embodiment of the present invention. In this embodiment, stem [0043] 32 of anchor 30 is positioned parallel to strut 24 in a lap joint configuration. Stem 32 of anchor member 30 is fixedly joined to strut 24 by a sacrificial link 60. As in the previous embodiment, sacrificial link 60 may be created using a process similar to brazing or soldering. The filler metal used in this process would be one which is susceptible to electrolytic disintegration/weakening in blood.
  • In FIG. 5 it can be appreciated that [0044] thrombus filter 20 can be formed from the struts 24 shown in FIG. 5 as an alternative to those shown in FIG. 2. This alternative embodiment of thrombus filter 20 can include an insulating layer 39 substantially covering thrombus filter 20 including body portion 22, struts 24, and anchor members 30 (thrombus filter 20 and body portion 22 not shown in FIG. 5) In FIG. 5, insulating layer 39 is shown covering strut 24, anchor member 30, and a portion of sacrificial link 60. Insulation layer 39 includes opening 61 proximate sacrificial link 60. Opening 61 of insulating layer 39 allows direct contact between sacrificial link 60 and the patient's blood. This direct contact creates a conductive path between sacrificial link 60 and the body of the patient. The significance of this conductive path is described in the following paragraph.
  • The embodiments shown in FIGS. 3, 4, and [0045] 5 include a sacrificial link comprised of a material which is susceptible to electrolytic disintegration/weakening in blood. When it is desirable to remove thrombus filter 20 from a blood vessel, an electrical current is passed through sacrificial links 40, 50, 60. This electrical current causes sacrificial links 40,50, 60 to corrode, dissolve, or disintegrate until the bond between free end 28 of strut 24 and stem 32 of anchor 30 is broken or weakened.
  • FIG. 6 schematically illustrates a [0046] thrombus filter 20 disposed in a lumen 102 of blood vessel 100. As described previously, joined ends 26 of struts 24 are fixedly joined to body portion 22. Free ends 28 of struts 24 are fixedly attached to anchors 30 by sacrificial links 60.
  • [0047] Blood vessel 100 includes walls 104 having a thin inner membrane or intima 106. Anchors 30 have punctured inner membrane 106 and are embedded in walls 104 of blood vessel 100. The body responds to the puncturing of inner membrane 106 with a process referred to as neointimal hyperplasia. The punctured area of inner membrane 106 is overgrown with a multitude of new cells. In FIG. 6, these new cells are illustrated as encapsulating cell growth 108. Within about 2 to 3 weeks after a thrombus filter is implanted, anchors 30 will be completely encapsulated by encapsulating cell growth 108. With many prior art thrombus filters, removal of the filter after neointimal hyperplasia encapsulation has occurred is very difficult, if not impossible.
  • A preferred embodiment of the thrombus filter in accordance with the present invention can be removed using minimally invasive methods without complications due to neointimal hyperplasia of [0048] anchors 30. A minimally invasive process which may be used to remove thrombus filter 20 from blood vessel 100 is schematically represented in FIG. 6.
  • A [0049] removal catheter 110 with a lumen 112 and a distal end 114 is disposed in lumen 102 of blood vessel 100. Removal catheter 110 enters the patients vascular system at a point which is readily accessible to the physician. Once in the vascular system, catheter 110 is urged forward until distal end 114 is proximate to the thrombus filter 20.
  • A first [0050] electrical conductor 115 is disposed inside lumen 112 of-removal catheter 110. First electrical conductor 115 includes a proximal end 116 and a distal end 118. Distal end 118 of first electrical conductor 115 has penetrated insulating layer 39 (not shown) to form an electrical connection with body portion 22 of thrombus filter 20. Proximal end 116 of first electrical conductor 115 is electrically connected to a power supply 120. A proximal end 122 of a second electrical conductor is also electrically connected to power supply 120. A distal end 126 of second electrical conductor 124 is electrically connected to an area of exposed skin 128 of a living being. The connection between second electrical conductor 124 and skin 128 is preferably made via an electrode 130.
  • A number of methods suitable for forming the electrical connection between first [0051] electrical connector 114 and body portion 22 of thrombus filter 20 are known in the art. For example, a needle electrode could be disposed at distal end 118 of electrical connector 114. The needle electrode could penetrate insulating layer 39 and make electrical contact with body portion 22 of thrombus filter 20. An easily deformed material such as silicone rubber or silicone foam rubber could be disposed around the needle electrode to insulate the electrical connection.
  • [0052] Power supply 120 is used to selectively apply a voltage differential between first electrical conductor 114 and second electrical conductor 124. This voltage differential induces a current flow 200 through sacrificial links 60 ( links 40 and 50 could be sacrificed in this manner as well). In FIG. 6, the path which current flow 200 takes through the body of the patient is represented by a dashed link. Current flow 200 causes sacrificial links 60 to corrode, dissolve, or disintegrate until the bond between free end 28 of strut 24 and stem 32 of anchor 30 are broken or weakened. When the bonds between struts 24 and anchors 30 is broken or weakened, thrombus filter 20 may be pulled into lumen 112 of retrieval catheter 110.
  • FIG. 7 is a schematic representation of [0053] thrombus filter 20 after it has been pulled into lumen 112 of retrieval catheter 110. As may be seen in FIG. 7, pulling thrombus filter 20 into lumen 112 of retrieval catheter 110 causes struts 24 to collapse. When struts 24 collapse thrombus filter 20 is transformed from a generally conical shape to a generally cylindrical shape. The pulling of thrombus filter 20 into lumen 112 of retrieval catheter 110 may be accomplished with a retrieval wire 140 including a hook 142. As can also be seen in FIG. 7, anchor members 30 remain fixed in the walls of blood vessel 100 by encapsulating cell growth 108. When thrombus filter 20 is pulled into lumen 112 of retrieval catheter 110, the removal of thrombus filter 20 from the patient becomes a simple matter of withdrawing removal catheter 110 from lumen 102 of blood vessel 100.
  • FIG. 8 illustrates an additional embodiment of the present invention. In this embodiment, [0054] free end 28 of strut 24 includes a bend 80 and a sharp projection 84. Bend 80 and sharp projection 84 enable free end 28 of strut 24 to anchor thrombus filter 20 into the walls of a blood vessel. Strut 24 substantially covered with a layer of insulating material 39. A thrombus filter 20 of the embodiment shown in FIG. 8 includes an insulating layer 39 substantially covering thrombus filter 20 including body portion 22 (not shown) and struts 24. Insulation layer 39 includes an opening 82 proximate free end 28 of strut 24. Opening 82 of insulating layer 39 allows direct contact between strut 24 and the patient's blood. This direct contact creates a conductive path between strut 24 and the body of the patient.
  • The embodiment of FIG. 8 may be removed using a process similar to that shown in FIG. 6. A first electrical conductor forms an electrical connection with the body portion of the thrombus filter. A second electrical conductor forms an electrical connection with the patient's body. This connection may be via an electrode placed on the patient's skin as shown in FIG. 6. It should be understood that the electrical connection to the patient's body may be accomplished using other methods without departing from the spirit or scope of the invention. For example, the connection to the patients body may be made through an electrode disposed on the retrieval catheter which makes direct contact with the patient's blood. [0055]
  • A power supply is used to selectively apply a voltage differential between the body portion of the thrombus filter and body of the patient. This voltage differential induces a current flow through the thrombus filter. In the embodiment of FIG. 8, current flows between [0056] strut 24 and opening 82 in insulating layer 39.
  • The flow of electrical current between [0057] strut 24 and the patients blood causes the electrolytic corrosion of strut 24 in an area proximate opening 82 in insulating layer 39. The current flow is continued until strut 24 has been weakened or cut through by electrolytic corrosion. To reduce the time required for the removal of thrombus filter 20, the cross sectional area of strut 24 may be reduced proximate opening 82 in insulating layer 39. When struts 24 of thrombus filter 20 are weakened or cut through, thrombus filter 20 may be pulled into a retrieval catheter.
  • Numerous advantages of the invention covered by this document have been set forth in the foregoing description. It will be understood, however, that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of parts without exceeding the scope of the invention. The invention's scope is, of course, defined in the language in which the appended claims are expressed. [0058]

Claims (19)

What is claimed is:
1. A thrombus filter configured for placement within a blood vessel lumen defined by a blood vessel wall, comprising:
a body portion;
a plurality of struts, each strut having a joined end and a free end;
the joined end of each strut being fixedly attached to the body portion; and
an anchor member joined to the free end of each strut by a sacrificial link.
2. The thrombus filter of
claim 1
, wherein each anchor member includes a sharp projection.
3. The thrombus filter of
claim 1
, wherein the sacrificial link is susceptible to electrolytic weakening in blood.
4. The thrombus filter of
claim 1
wherein an insulating layer is axially disposed about the struts.
5. The thrombus filter of
claim 1
, wherein an insulating layer is selectively disposed about the body portion.
6. The thrombus filter of
claim 1
, wherein each strut is rectangular in cross section.
7. The thrombus filter of
claim 1
, wherein each strut is circular in cross section.
8. A thrombus filter configured for placement within a blood vessel lumen defined by a blood vessel wall, comprising:
a body portion;
a plurality of struts, each strut having a joined end and a free end;
the joined end of each strut being fixedly attached to the body portion;
an anchor member including a sharp projection and a stem; and
means for attaching the anchor member to the free end of the strut by interference fit.
9. The thrombus filter of
claim 8
, wherein the struts have a circular cross section.
10. The thrombus filter of
claim 8
, wherein the sleeves have a tubular cross section, and the stems of the anchors have a circular cross section.
11. The thrombus filter of
claim 8
, wherein the struts have a rectangular cross section.
12. The thrombus filter of
claim 8
, wherein the means for attaching includes a sleeve.
13. The thrombus filter of
claim 12
, wherein each sleeve is attached to each strut with a weld joint.
14. The thrombus filter of
claim 12
, wherein each sleeve is attached to each strut with a solder joint.
15. A method of removing a thrombus filter from a blood vessel lumen inside a living being, the method comprising the steps of:
providing a thrombus filter comprising, a body portion, a plurality of struts, each strut having a joined end and a free end, the joined end of each strut being fixedly attached to the body portion, and an anchor member joined to the free end of each strut by a sacrificial link;
connecting a first electrical conductor to the body portion of the thrombus filter;
connecting a second electrical conductor to the living being; and
creating a voltage differential between the first electrical conductor and the second electrical conductor whereby the sacrificial links are dissolved by electrolytic corrosion.
16. The method of
claim 15
, wherein each anchor member includes a sharp projection.
17. The method of
claim 15
, wherein the sacrificial link is susceptible to electrolytic weakening in blood.
18. The method of
claim 15
, wherein an insulating layer is axially disposed about the struts.
19. The method of
claim 15
, wherein an insulating layer is selectively disposed about the body portion.
US09/904,259 2000-01-26 2001-07-12 Device and method for selectively removing a thrombus filter Expired - Lifetime US6416530B2 (en)

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Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060058832A1 (en) * 2002-12-12 2006-03-16 Andreas Melzer Vessel filter
US20080255605A1 (en) * 2007-04-13 2008-10-16 C.R. Bard, Inc. Migration resistant embolic filter
US20080306478A1 (en) * 2007-06-06 2008-12-11 Scott H. Bradshaw Method and Apparatus for Electrochemically Dissolving Selected Regions of Conducting Objects in Tissue
US20090248060A1 (en) * 2008-03-19 2009-10-01 Schneider M Bret Electrostatic vascular filters
US7662165B2 (en) 1997-11-07 2010-02-16 Salviac Limited Embolic protection device
US7704267B2 (en) 2004-08-04 2010-04-27 C. R. Bard, Inc. Non-entangling vena cava filter
US7766934B2 (en) 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US7780697B2 (en) 1997-11-07 2010-08-24 Salviac Limited Embolic protection system
US7794473B2 (en) 2004-11-12 2010-09-14 C.R. Bard, Inc. Filter delivery system
US7799051B2 (en) 1999-05-07 2010-09-21 Salviac Limited Support frame for an embolic protection device
US7850708B2 (en) 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US7901427B2 (en) 1997-11-07 2011-03-08 Salviac Limited Filter element with retractable guidewire tip
US7927349B2 (en) 2001-12-21 2011-04-19 Salviac Limited Support frame for an embolic protection device
US8002790B2 (en) 1999-05-07 2011-08-23 Salviac Limited Support frame for an embolic protection device
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US8152831B2 (en) 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US8182508B2 (en) 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US8187298B2 (en) 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US8252018B2 (en) 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
US8252017B2 (en) 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
US8267954B2 (en) 2005-02-04 2012-09-18 C. R. Bard, Inc. Vascular filter with sensing capability
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US8419748B2 (en) 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US8430903B2 (en) 2005-08-09 2013-04-30 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US20130138137A1 (en) * 2010-01-12 2013-05-30 Cook Medical Technologies Llc Visual stabilizer on anchor legs of vena cava filter
US8574261B2 (en) 2005-05-12 2013-11-05 C. R. Bard, Inc. Removable embolus blood clot filter
US8613754B2 (en) 2005-05-12 2013-12-24 C. R. Bard, Inc. Tubular filter
US8632562B2 (en) 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8690906B2 (en) 1998-09-25 2014-04-08 C.R. Bard, Inc. Removeable embolus blood clot filter and filter delivery unit
US8795315B2 (en) 2004-10-06 2014-08-05 Cook Medical Technologies Llc Emboli capturing device having a coil and method for capturing emboli
US8945169B2 (en) 2005-03-15 2015-02-03 Cook Medical Technologies Llc Embolic protection device
US9131999B2 (en) 2005-11-18 2015-09-15 C.R. Bard Inc. Vena cava filter with filament
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US9204956B2 (en) 2002-02-20 2015-12-08 C. R. Bard, Inc. IVC filter with translating hooks
US9295393B2 (en) 2012-11-09 2016-03-29 Elwha Llc Embolism deflector
US9326842B2 (en) 2006-06-05 2016-05-03 C. R . Bard, Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US20170112501A1 (en) * 2014-03-21 2017-04-27 The United States of America, as represented by the Secretary, Department of Health & Human Servic Conductive and retrievable devices
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
US9907639B2 (en) 2006-09-19 2018-03-06 Cook Medical Technologies Llc Apparatus and methods for in situ embolic protection
US10123864B2 (en) * 2014-06-30 2018-11-13 Cook Medical Technologies Llc Vascular filter and anchoring arrangement thereof
US10188496B2 (en) 2006-05-02 2019-01-29 C. R. Bard, Inc. Vena cava filter formed from a sheet
WO2019045705A1 (en) * 2017-08-30 2019-03-07 C.R. Bard, Inc. Interventional medical device having reduced fracture risk
CN112998918A (en) * 2016-01-12 2021-06-22 W.L.戈尔及同仁股份有限公司 Selectively degradable implantable devices

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267776B1 (en) * 1999-05-03 2001-07-31 O'connell Paul T. Vena cava filter and method for treating pulmonary embolism
DE29916162U1 (en) * 1999-09-14 2000-01-13 Cormedics Gmbh Vascular filter system
US20050096669A1 (en) * 1999-10-05 2005-05-05 Omnisonics Medical Technologies, Inc. Apparatus and method for an ultrasonic medical device to treat coronary thrombus bearing lesions
US20040097996A1 (en) 1999-10-05 2004-05-20 Omnisonics Medical Technologies, Inc. Apparatus and method of removing occlusions using an ultrasonic medical device operating in a transverse mode
US6217600B1 (en) * 2000-01-26 2001-04-17 Scimed Life Systems, Inc. Thrombus filter with break-away anchor members
US6517573B1 (en) * 2000-04-11 2003-02-11 Endovascular Technologies, Inc. Hook for attaching to a corporeal lumen and method of manufacturing
US7147649B2 (en) * 2000-08-04 2006-12-12 Duke University Temporary vascular filters
US6582447B1 (en) * 2000-10-20 2003-06-24 Angiodynamics, Inc. Convertible blood clot filter
US20040073252A1 (en) * 2001-02-20 2004-04-15 Mark Goldberg Blood clot filtering system
US6506205B2 (en) * 2001-02-20 2003-01-14 Mark Goldberg Blood clot filtering system
US6623506B2 (en) * 2001-06-18 2003-09-23 Rex Medical, L.P Vein filter
JP2005519644A (en) * 2001-06-18 2005-07-07 レックス メディカル リミテッド パートナーシップ Vein filter
US8282668B2 (en) * 2001-06-18 2012-10-09 Rex Medical, L.P. Vein filter
US6793665B2 (en) * 2001-06-18 2004-09-21 Rex Medical, L.P. Multiple access vein filter
US7179275B2 (en) * 2001-06-18 2007-02-20 Rex Medical, L.P. Vein filter
US20040243170A1 (en) * 2001-09-05 2004-12-02 Mitta Suresh Method and device for percutaneous surgical ventricular repair
US6881218B2 (en) * 2002-05-01 2005-04-19 Angiodynamics, Inc. Blood clot filter
WO2004024032A1 (en) * 2002-09-12 2004-03-25 Cook Incorporated Retrievable filter
US7534251B2 (en) * 2003-02-11 2009-05-19 Boston Scientific Scimed, Inc. Retrievable IVC filter
WO2004071343A2 (en) * 2003-02-11 2004-08-26 Cook, Inc. Removable vena cava filter
US6902572B2 (en) * 2003-04-02 2005-06-07 Scimed Life Systems, Inc. Anchoring mechanisms for intravascular devices
US7056286B2 (en) * 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
US20050137620A1 (en) * 2003-12-22 2005-06-23 Scimed Life Systems, Inc. Balloon catheter retrieval device
US20050209632A1 (en) * 2004-01-14 2005-09-22 Wallace Michael J Filtering devices
US8062326B2 (en) 2004-01-22 2011-11-22 Rex Medical, L.P. Vein filter
US9510929B2 (en) 2004-01-22 2016-12-06 Argon Medical Devices, Inc. Vein filter
US7338512B2 (en) * 2004-01-22 2008-03-04 Rex Medical, L.P. Vein filter
US7976562B2 (en) 2004-01-22 2011-07-12 Rex Medical, L.P. Method of removing a vein filter
US8500774B2 (en) 2004-01-22 2013-08-06 Rex Medical, L.P. Vein filter
US8162972B2 (en) 2004-01-22 2012-04-24 Rex Medical, Lp Vein filter
US7704266B2 (en) 2004-01-22 2010-04-27 Rex Medical, L.P. Vein filter
US8211140B2 (en) * 2004-01-22 2012-07-03 Rex Medical, L.P. Vein filter
US7794414B2 (en) 2004-02-09 2010-09-14 Emigrant Bank, N.A. Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes
US7867245B2 (en) * 2004-02-09 2011-01-11 The United States Of America As Represented By The Department Of Health And Human Services Venous filters
US7323003B2 (en) * 2004-02-13 2008-01-29 Boston Scientific Scimed, Inc. Centering intravascular filters and devices and methods for deploying and retrieving intravascular filters
EP1737385B1 (en) * 2004-04-16 2010-12-15 Cook Incorporated Removable vena cava filter with anchoring feature for reduced trauma
US7699867B2 (en) * 2004-04-16 2010-04-20 Cook Incorporated Removable vena cava filter for reduced trauma in collapsed configuration
ES2335903T3 (en) * 2004-04-16 2010-04-06 Cook, Inc. VENA CAVA REMOVABLE FILTER THAT HAS ANCHORING HOOKS POSITIONED INWARDS IN COLLAPSED CONFIGURATION.
US8105349B2 (en) * 2004-04-16 2012-01-31 Cook Medical Technologies Llc Removable vena cava filter having primary struts for enhanced retrieval and delivery
US8998944B2 (en) * 2004-06-10 2015-04-07 Lifescreen Sciences Llc Invertible intravascular filter
US8529595B2 (en) 2004-06-30 2013-09-10 Boston Scientific Scimed, Inc. Intravascular filter
US20060015137A1 (en) * 2004-07-19 2006-01-19 Wasdyke Joel M Retrievable intravascular filter with bendable anchoring members
US8403955B2 (en) * 2004-09-02 2013-03-26 Lifescreen Sciences Llc Inflatable intravascular filter
BRPI0516135B8 (en) * 2004-09-27 2021-06-22 Cook Medical Technologies Llc removable filter for capturing thrombi in a blood vessel
US7749246B2 (en) 2004-09-27 2010-07-06 Rex Medical, L.P. Vein filter
US20060100660A1 (en) * 2004-11-08 2006-05-11 Cook Incorporated Blood clot filter configured for a wire guide
US20060206138A1 (en) * 2005-03-09 2006-09-14 Eidenschink Tracee E Intravascular filter assembly
US7998164B2 (en) * 2005-03-11 2011-08-16 Boston Scientific Scimed, Inc. Intravascular filter with centering member
US20060224175A1 (en) * 2005-03-29 2006-10-05 Vrba Anthony C Methods and apparatuses for disposition of a medical device onto an elongate medical device
KR20070117705A (en) * 2005-04-04 2007-12-12 비. 브라운 메디컬 에스에이에스 Removable filter head
US20060259132A1 (en) * 2005-05-02 2006-11-16 Cook Incorporated Vascular stent for embolic protection
US20060282112A1 (en) * 2005-06-09 2006-12-14 Stephen Griffin Method and apparatus for enhanced electrolytic detachment
US8292946B2 (en) * 2005-10-25 2012-10-23 Boston Scientific Scimed, Inc. Medical implants with limited resistance to migration
US20070100372A1 (en) * 2005-11-02 2007-05-03 Cook Incorporated Embolic protection device having a filter
US10076401B2 (en) 2006-08-29 2018-09-18 Argon Medical Devices, Inc. Vein filter
US20080294189A1 (en) * 2007-05-23 2008-11-27 Moll Fransiscus L Vein filter
US8246672B2 (en) 2007-12-27 2012-08-21 Cook Medical Technologies Llc Endovascular graft with separately positionable and removable frame units
US20090257970A1 (en) * 2008-03-14 2009-10-15 Ernest Bloom Antiperspirant compositions containing a copper salt and a penetration enhancer and methods of using the same
US20090254117A1 (en) * 2008-04-03 2009-10-08 Pakter Robert L Venous Filter with Detachable Anchors
DE102008040253A1 (en) 2008-07-08 2010-01-14 Biotronik Vi Patent Ag Implant system with a functional implant made of degradable metal material
US8246648B2 (en) * 2008-11-10 2012-08-21 Cook Medical Technologies Llc Removable vena cava filter with improved leg
US20100211094A1 (en) * 2009-02-18 2010-08-19 Cook Incorporated Umbrella distal embolic protection device
US20100274277A1 (en) * 2009-04-27 2010-10-28 Cook Incorporated Embolic protection device with maximized flow-through
US10092427B2 (en) * 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
EP2624791B1 (en) * 2010-10-08 2017-06-21 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design
JP2013540040A (en) * 2010-10-20 2013-10-31 ウルフ トリー メディカル インコーポレイテッド Small fluid sprayer
US8940012B2 (en) 2010-12-07 2015-01-27 Boston Scientific Scimed, Inc. Intravascular filter with biodegradable force-reducing element
US10022212B2 (en) 2011-01-13 2018-07-17 Cook Medical Technologies Llc Temporary venous filter with anti-coagulant delivery method
CN102499734B (en) * 2011-11-17 2013-06-19 祖茂衡 Remover for thrombus in stents
US10278803B2 (en) 2013-03-12 2019-05-07 Cook Medical Technologies Llc Vena cava filter removal device
EP3068337B1 (en) 2013-11-13 2022-10-05 Covidien LP Galvanically assisted attachment of medical devices to thrombus
US10265515B2 (en) 2015-03-27 2019-04-23 Covidien Lp Galvanically assisted aneurysm treatment
WO2017053784A1 (en) 2015-09-25 2017-03-30 Covidien Lp Medical device delivery system
US11819215B2 (en) 2018-04-04 2023-11-21 Incumedx Inc. Embolic device with improved neck coverage
JP7252181B2 (en) * 2020-08-26 2023-04-04 シー・アール・バード・インコーポレーテッド Interventional medical device with reduced breakage risk

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US4494531A (en) 1982-12-06 1985-01-22 Cook, Incorporated Expandable blood clot filter
US4727873A (en) 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
FR2573646B1 (en) 1984-11-29 1988-11-25 Celsa Composants Electr Sa PERFECTED FILTER, PARTICULARLY FOR THE RETENTION OF BLOOD CLOTS
US4793348A (en) 1986-11-15 1988-12-27 Palmaz Julio C Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation
FR2606641B1 (en) 1986-11-17 1991-07-12 Promed FILTERING DEVICE FOR BLOOD CLOTS
US5174295A (en) 1987-04-10 1992-12-29 Cardiometrics, Inc. Apparatus, system and method for measuring spatial average velocity and/or volumetric flow of blood in a vessel and screw joint for use therewith
US4817600A (en) 1987-05-22 1989-04-04 Medi-Tech, Inc. Implantable filter
US5059205A (en) 1989-09-07 1991-10-22 Boston Scientific Corporation Percutaneous anti-migration vena cava filter
US5242462A (en) 1989-09-07 1993-09-07 Boston Scientific Corp. Percutaneous anti-migration vena cava filter
GB2238485B (en) 1989-11-28 1993-07-14 Cook William Europ A collapsible filter for introduction in a blood vessel of a patient
US5354295A (en) 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
FR2663217B1 (en) 1990-06-15 1992-10-16 Antheor FILTERING DEVICE FOR THE PREVENTION OF EMBOLIES.
US5147379A (en) 1990-11-26 1992-09-15 Louisiana State University And Agricultural And Mechanical College Insertion instrument for vena cava filter
US5324304A (en) 1992-06-18 1994-06-28 William Cook Europe A/S Introduction catheter set for a collapsible self-expandable implant
FR2694491B1 (en) 1992-08-07 1994-09-30 Celsa Lg Triangular tab filters.
FR2699809B1 (en) 1992-12-28 1995-02-17 Celsa Lg Device which can selectively constitute a temporary blood filter.
JPH09503409A (en) 1993-10-01 1997-04-08 ボストン・サイエンティフィック・コーポレーション Improved vena cava filter
US5423829A (en) 1993-11-03 1995-06-13 Target Therapeutics, Inc. Electrolytically severable joint for endovascular embolic devices
US5380320A (en) 1993-11-08 1995-01-10 Advanced Surgical Materials, Inc. Electrosurgical instrument having a parylene coating
FR2714814B1 (en) * 1994-01-10 1996-03-29 Bentex Trading Sa Device intended to be placed in a vessel with flattened fixing lugs.
ES2242957T3 (en) 1994-03-03 2005-11-16 Boston Scientific Limited DEVICE FOR DETECTING THE SEPARATION OF A VASCULAR OCLUSION DEVICE.
US5522836A (en) * 1994-06-27 1996-06-04 Target Therapeutics, Inc. Electrolytically severable coil assembly with movable detachment point
US5709704A (en) 1994-11-30 1998-01-20 Boston Scientific Corporation Blood clot filtering
US5681347A (en) 1995-05-23 1997-10-28 Boston Scientific Corporation Vena cava filter delivery system
US5704910A (en) 1995-06-05 1998-01-06 Nephros Therapeutics, Inc. Implantable device and use therefor
DE942767T1 (en) 1996-11-27 2000-04-06 Boston Scient Corp MECHANISM FOR ANCHORING AND RELEASING A PERMANENT IMPLANT
US6086577A (en) * 1997-08-13 2000-07-11 Scimed Life Systems, Inc. Detachable aneurysm neck bridge (III)
JPH1191623A (en) 1997-09-18 1999-04-06 Unisia Jecs Corp Cab suspension controller
US6036720A (en) * 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US6267776B1 (en) 1999-05-03 2001-07-31 O'connell Paul T. Vena cava filter and method for treating pulmonary embolism
US6217600B1 (en) * 2000-01-26 2001-04-17 Scimed Life Systems, Inc. Thrombus filter with break-away anchor members

Cited By (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7972352B2 (en) 1997-11-07 2011-07-05 Salviac Limited Embolic protection system
US8852226B2 (en) 1997-11-07 2014-10-07 Salviac Limited Vascular device for use during an interventional procedure
US8603131B2 (en) 1997-11-07 2013-12-10 Salviac Limited Embolic protection device
US8430901B2 (en) 1997-11-07 2013-04-30 Salviac Limited Embolic protection device
US7662165B2 (en) 1997-11-07 2010-02-16 Salviac Limited Embolic protection device
US8328842B2 (en) 1997-11-07 2012-12-11 Salviac Limited Filter element with retractable guidewire tip
US8241319B2 (en) 1997-11-07 2012-08-14 Salviac Limited Embolic protection system
US8226678B2 (en) 1997-11-07 2012-07-24 Salviac Limited Embolic protection device
US8221448B2 (en) 1997-11-07 2012-07-17 Salviac Limited Embolic protection device
US7780697B2 (en) 1997-11-07 2010-08-24 Salviac Limited Embolic protection system
US7785342B2 (en) 1997-11-07 2010-08-31 Salviac Limited Embolic protection device
US8216270B2 (en) 1997-11-07 2012-07-10 Salviac Limited Embolic protection device
US8123776B2 (en) 1997-11-07 2012-02-28 Salviac Limited Embolic protection system
US7833242B2 (en) 1997-11-07 2010-11-16 Salviac Limited Embolic protection device
US7837701B2 (en) 1997-11-07 2010-11-23 Salviac Limited Embolic protection device
US7842066B2 (en) 1997-11-07 2010-11-30 Salviac Limited Embolic protection system
US7842063B2 (en) 1997-11-07 2010-11-30 Salviac Limited Embolic protection device
US7846176B2 (en) 1997-11-07 2010-12-07 Salviac Limited Embolic protection system
US8057504B2 (en) 1997-11-07 2011-11-15 Salviac Limited Embolic protection device
US8052716B2 (en) 1997-11-07 2011-11-08 Salviac Limited Embolic protection system
US7901427B2 (en) 1997-11-07 2011-03-08 Salviac Limited Filter element with retractable guidewire tip
US7901426B2 (en) 1997-11-07 2011-03-08 Salviac Limited Embolic protection device
US9351821B2 (en) 1998-09-25 2016-05-31 C. R. Bard, Inc. Removable embolus blood clot filter and filter delivery unit
US8690906B2 (en) 1998-09-25 2014-04-08 C.R. Bard, Inc. Removeable embolus blood clot filter and filter delivery unit
US9615909B2 (en) 1998-09-25 2017-04-11 C.R. Bard, Inc. Removable embolus blood clot filter and filter delivery unit
US8002790B2 (en) 1999-05-07 2011-08-23 Salviac Limited Support frame for an embolic protection device
US7799051B2 (en) 1999-05-07 2010-09-21 Salviac Limited Support frame for an embolic protection device
US7927349B2 (en) 2001-12-21 2011-04-19 Salviac Limited Support frame for an embolic protection device
US8114115B2 (en) 2001-12-21 2012-02-14 Salviac Limited Support frame for an embolic protection device
US9204956B2 (en) 2002-02-20 2015-12-08 C. R. Bard, Inc. IVC filter with translating hooks
US20060058832A1 (en) * 2002-12-12 2006-03-16 Andreas Melzer Vessel filter
US7766932B2 (en) * 2002-12-12 2010-08-03 Amris Patente Gmbh Vessel filter
US8628556B2 (en) 2004-08-04 2014-01-14 C. R. Bard, Inc. Non-entangling vena cava filter
US9144484B2 (en) 2004-08-04 2015-09-29 C. R. Bard, Inc. Non-entangling vena cava filter
US8372109B2 (en) 2004-08-04 2013-02-12 C. R. Bard, Inc. Non-entangling vena cava filter
US7704267B2 (en) 2004-08-04 2010-04-27 C. R. Bard, Inc. Non-entangling vena cava filter
US11103339B2 (en) 2004-08-04 2021-08-31 C. R. Bard, Inc. Non-entangling vena cava filter
US8795315B2 (en) 2004-10-06 2014-08-05 Cook Medical Technologies Llc Emboli capturing device having a coil and method for capturing emboli
US8992562B2 (en) 2004-11-12 2015-03-31 C.R. Bard, Inc. Filter delivery system
US10512531B2 (en) 2004-11-12 2019-12-24 C. R. Bard, Inc. Filter delivery system
US7794473B2 (en) 2004-11-12 2010-09-14 C.R. Bard, Inc. Filter delivery system
US8267954B2 (en) 2005-02-04 2012-09-18 C. R. Bard, Inc. Vascular filter with sensing capability
US8945169B2 (en) 2005-03-15 2015-02-03 Cook Medical Technologies Llc Embolic protection device
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US10813738B2 (en) 2005-05-12 2020-10-27 C.R. Bard, Inc. Tubular filter
US8574261B2 (en) 2005-05-12 2013-11-05 C. R. Bard, Inc. Removable embolus blood clot filter
US11730583B2 (en) 2005-05-12 2023-08-22 C.R. Band. Inc. Tubular filter
US9017367B2 (en) 2005-05-12 2015-04-28 C. R. Bard, Inc. Tubular filter
US10729527B2 (en) 2005-05-12 2020-08-04 C.R. Bard, Inc. Removable embolus blood clot filter
US9498318B2 (en) 2005-05-12 2016-11-22 C.R. Bard, Inc. Removable embolus blood clot filter
US8613754B2 (en) 2005-05-12 2013-12-24 C. R. Bard, Inc. Tubular filter
US11554006B2 (en) 2005-05-12 2023-01-17 C. R. Bard Inc. Removable embolus blood clot filter
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US7850708B2 (en) 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US8845677B2 (en) 2005-06-20 2014-09-30 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US7766934B2 (en) 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
US7867247B2 (en) 2005-07-12 2011-01-11 Cook Incorporated Methods for embolic protection during treatment of a stenotic lesion in a body vessel
US8187298B2 (en) 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
US8430903B2 (en) 2005-08-09 2013-04-30 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US10492898B2 (en) 2005-08-09 2019-12-03 C.R. Bard, Inc. Embolus blood clot filter and delivery system
US9387063B2 (en) 2005-08-09 2016-07-12 C. R. Bard, Inc. Embolus blood clot filter and delivery system
US11517415B2 (en) 2005-08-09 2022-12-06 C.R. Bard, Inc. Embolus blood clot filter and delivery system
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US8632562B2 (en) 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8182508B2 (en) 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US8252017B2 (en) 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
US8152831B2 (en) 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US9131999B2 (en) 2005-11-18 2015-09-15 C.R. Bard Inc. Vena cava filter with filament
US10842608B2 (en) 2005-11-18 2020-11-24 C.R. Bard, Inc. Vena cava filter with filament
US10980626B2 (en) 2006-05-02 2021-04-20 C. R. Bard, Inc. Vena cava filter formed from a sheet
US10188496B2 (en) 2006-05-02 2019-01-29 C. R. Bard, Inc. Vena cava filter formed from a sheet
US11141257B2 (en) 2006-06-05 2021-10-12 C. R. Bard, Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US9326842B2 (en) 2006-06-05 2016-05-03 C. R . Bard, Inc. Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access
US9907639B2 (en) 2006-09-19 2018-03-06 Cook Medical Technologies Llc Apparatus and methods for in situ embolic protection
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
US8795351B2 (en) 2007-04-13 2014-08-05 C.R. Bard, Inc. Migration resistant embolic filter
US11617640B2 (en) 2007-04-13 2023-04-04 C.R. Bard, Inc. Migration resistant embolic filter
US10390925B2 (en) 2007-04-13 2019-08-27 C.R. Bard, Inc. Migration resistant embolic filter
US20080255605A1 (en) * 2007-04-13 2008-10-16 C.R. Bard, Inc. Migration resistant embolic filter
US20080306478A1 (en) * 2007-06-06 2008-12-11 Scott H. Bradshaw Method and Apparatus for Electrochemically Dissolving Selected Regions of Conducting Objects in Tissue
US9398946B2 (en) 2007-09-14 2016-07-26 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US8252018B2 (en) 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US8419748B2 (en) 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US20090248060A1 (en) * 2008-03-19 2009-10-01 Schneider M Bret Electrostatic vascular filters
US8246649B2 (en) * 2008-03-19 2012-08-21 Schneider M Bret Electrostatic vascular filters
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US8657849B2 (en) 2008-12-29 2014-02-25 Cook Medical Technologies Llc Embolic protection device and method of use
US9308066B2 (en) * 2010-01-12 2016-04-12 Cook Medical Technologies Llc Visual stabilizer on anchor legs of vena cava filter
US10258454B2 (en) * 2010-01-12 2019-04-16 Cook Medical Technologies Llc Visual stabilizer on anchor legs of vena cava filter
US20170128185A1 (en) * 2010-01-12 2017-05-11 Cook Medical Technologies Llc Visual stabilizer on anchor legs of vena cava filter
US9592107B2 (en) 2010-01-12 2017-03-14 Cook Medical Technologies Llc Visual stabilizer on anchor legs of vena cava filter
US20130138137A1 (en) * 2010-01-12 2013-05-30 Cook Medical Technologies Llc Visual stabilizer on anchor legs of vena cava filter
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
US9295393B2 (en) 2012-11-09 2016-03-29 Elwha Llc Embolism deflector
EP3119350A4 (en) * 2014-03-21 2017-12-27 The U.S.A. as represented by the Secretary, Department of Health and Human Services Conductive and retrievable devices
US20170112501A1 (en) * 2014-03-21 2017-04-27 The United States of America, as represented by the Secretary, Department of Health & Human Servic Conductive and retrievable devices
US10123864B2 (en) * 2014-06-30 2018-11-13 Cook Medical Technologies Llc Vascular filter and anchoring arrangement thereof
CN112998918A (en) * 2016-01-12 2021-06-22 W.L.戈尔及同仁股份有限公司 Selectively degradable implantable devices
EP3906899A1 (en) * 2016-01-12 2021-11-10 W.L. Gore & Associates Inc. Implantable devices capable of selective degradation
WO2019045705A1 (en) * 2017-08-30 2019-03-07 C.R. Bard, Inc. Interventional medical device having reduced fracture risk

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JP4652654B2 (en) 2011-03-16
WO2001054617A1 (en) 2001-08-02
US6416530B2 (en) 2002-07-09
EP1253872A1 (en) 2002-11-06
CA2396708A1 (en) 2001-08-02
JP2003521309A (en) 2003-07-15
US6342063B1 (en) 2002-01-29
AU2001229729A1 (en) 2001-08-07

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