US20010000129A1 - Micro optical fiber sensor device - Google Patents
Micro optical fiber sensor device Download PDFInfo
- Publication number
- US20010000129A1 US20010000129A1 US09/729,611 US72961100A US2001000129A1 US 20010000129 A1 US20010000129 A1 US 20010000129A1 US 72961100 A US72961100 A US 72961100A US 2001000129 A1 US2001000129 A1 US 2001000129A1
- Authority
- US
- United States
- Prior art keywords
- light
- sample
- sensor
- sensor device
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
Definitions
- This invention relates generally to a sensor device and more particularly to a micro optical fiber sensor device which may be employed in a variety of sensor applications to monitor, sense, or measure a concentration of a material within a sample.
- a device is used to monitor or detect a concentration of material within a substance. For example, it may be required to know the concentration of a chemical in a sample of material such as knowing the concentration of sodium, calcium, or some other chemical composition in a sample.
- Monitoring or detecting a concentration of a substance typically requires a set up of relatively complex, sensitive, and expensive equipment or instrumentation. Sometimes space requirements make it difficult to use the set up of complex equipment and it would be advantageous to have equipment which has small dimensions and is easily transportable. Additionally, such complex equipment may not provide results which are of a high resolution.
- One known and important application for monitoring a concentration of a material within a sample deals with checking blood glucose for diabetics.
- the two techniques are invasive which involves extracting samples with the use of needles or syringes and noninvasive.
- a patient employs a small lancet device which is used to prick or puncture a finger. Blood is then collected onto a strip which has incorporated therein a chemical reagent. The strip is then placed inside of a device that optically reads the chemical reaction of the blood on the strip and converts this to a blood glucose level. It has been found very important to control glucose levels in diabetics to reduce any complications associated with diabetes.
- the present invention is designed to obviate and overcome many of the disadvantages and shortcomings associated with the prior use of complex testing and monitoring equipment. Additionally, the present invention is simple to use, provides extremely quick results and high resolution, and is easily transportable. The present invention uses relatively inexpensive components which results in a commercially viable product. Further, the micro optical fiber sensor device of the present invention is relatively noninvasive since it does not require the drawing of blood and provides immediate results which does not require related blood processing such as centrifugation, storage, transportation, and other time consuming testing.
- the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof, means for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light, and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample
- Another example of the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source for emitting a beam of light of a preselected wavelength with the light source being coupled to an optical device capable of transmitting the beam of light therethrough, the transmitted beam of light being directed into the first end of the sensor, through the sensor and out of the second end into a sample, the active material interacting with a substance within a sample to change the wavelength of the transmitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light from the second end, through the sensor, and out of the first end thereof, the optical device being further capable of reflecting the reflected beam of light, means for receiving the reflected beam of light which is
- a further example of the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and a first and a second active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the first active material capable of interacting with a first substance within a sample and the second active material capable of interacting with a second substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the first active material interacting with a first substance within a sample to change the wavelength of the emitted beam of light to produce a first reflected beam of light, the second active material interacting with a second substance within a sample to change the wavelength of the emitted beam of light to produce a second reflected beam of light, and the sensor for transmitting the first and second
- a principal object of the present invention is to provide an improved sensor device which is hand held, portable, and easy to operate.
- Another object of the present invention is to provide a sensor device which has a tip portion of an extremely small size so that when it is inserted into a hand of a patient little or no sensation will be produced or detected.
- a further object of the present invention is to provide a sensor device which is of simple construction and design and which can be easily employed with highly reliable results.
- Another object of the present invention is to provide a sensor device which is accurate and provides readings in a short time span.
- a still further object of the present invention is to provide a sensor device which is compact in design and is easily transportable for personal use.
- FIG. 1 is a perspective view of a micro optical fiber sensor device constructed according to the present invention.
- FIG. 2 is a block diagram of the micro optical fiber sensor device constructed according to the present invention.
- FIG. 3 is a perspective view of a tip portion of the micro optical fiber sensor device shown in FIG. 1;
- FIG. 4 is a schematic view of the micro optical fiber sensor device of the present invention being employed to sense a concentration in a sample
- FIG. 5 is a block diagram of a second embodiment of the micro optical fiber sensor device constructed according to the present invention.
- FIG. 6 is perspective view of the sensor device of FIG. 5 illustrated monitoring a concentration of glucose in a hand of a patient.
- FIG. 7 is a block diagram of a third embodiment of the micro optical fiber sensor device constructed according to the present invention.
- the device 10 comprises a pencil or pen shaped body 12 which includes a tip portion 14 , a central body portion 16 , and an end cap 18 .
- the central body portion 16 further includes a display device 20 , such as an LED (light emitting diode) type display or an LCD type display, for displaying information.
- the end cap 18 which may be removable from the central body portion 16 , is used to allow access into the interior of the central body portion 16 .
- Batteries (not shown) can be inserted into the central body portion 16 to supply power to the device 10 , as will be explained.
- the central body portion 16 may also include an ON/OFF switch 22 which may be used to operate the device 10 .
- Other switches may be incorporated into the central body portion 16 to further control the device 10 .
- the central body portion 16 houses electronic circuitry and other components which will be illustrated and explained in further detail herein.
- the device 10 is sized and shaped to be a hand held type device which is portable and preferably is the size and shape of a pencil or a pen.
- the device 10 includes a light source 30 which may be an LED, a laser, a laser diode, or other excitation source.
- the light source 30 is adapted to project a beam of light 32 into a section fiber optic 34 .
- the fiber optic 34 transmits a beam of light 36 to a tip portion or device 38 which is part of the tip portion 14 .
- the beam of light 36 passes through the tip device 38 and a reflected beam of light 40 can be reflected back from a sample (not shown) through the tip device 38 to a detector 42 .
- the reflected beam of light 40 typically has a wavelength or a frequency which is different than the wavelength or frequency of the beam of light 36 .
- the detector 42 is in turn connected to a computer 44 via an electrical connection such as a wire 46 .
- the detector 42 provides electrical signals over the wire 46 to the computer 44 .
- the computer 44 may consists of, by way of examples, a microprocessor, a microcontroller, an ASIC chip, or any other known equivalent device which is capable of processing electrical signals.
- the computer 44 is further operatively connected to a power supply 48 , such as batteries, by a wire 50 .
- the computer 44 may also connected to the display device 20 , the switch 22 , and the light source 30 although such connection is not illustrated in FIG. 2. Additionally, the computer 44 may also be connected to other switches (not shown) which may be provided with the device 10 . In this manner, the additional switches are used to further control or operate other functions of the device 10 .
- the tip device 38 is shown in greater detail in FIG. 3 and is preferably a small device on the order of microns in diameter.
- the tip device 38 may be constructed as is disclosed in U.S. Pat. Nos. 5,361,314 and 5,627,922.
- the tip device 38 includes a non-tapered fiber optic portion 60 and a tapered fiber optic portion 62 which is coated with an opaque material 64 .
- the tip device 38 further includes a first end 66 and a second end 68 .
- the second end 68 further has a tip or portion 70 of material which is adhered thereto.
- the tip 70 is chemically treated which enables the tip 70 to interact with the sample to be detected.
- the tip device 38 allows for the beam of light 36 to pass through the first end 66 , the second end 68 , and the tip portion 70 and the reflected beam 40 is allowed to pass through the tip portion 70 , the second end 68 , and the first end 66 .
- the tip device 38 is extremely small on the order of one-thousandth the width of a human hair and because of this size it can be inserted through gaps in most cells or through the membrane of a cell without damaging the cell.
- the tip 70 may be bathed in chemical coatings selected to react with biological compounds such as acid, calcium, oxygen, glucose, potassium, sodium, or any other material to be detected.
- the beam of light 36 which is transmitted through the tip device 38 glows with its brightness and color varying according to the concentration of the target chemical.
- the portion 70 is a photochemical sensor which is less than ten microns in diameter. Again, the portion 70 is small enough that it can pass through the membrane of a cell to monitor the concentration and nature of chemicals within the cell.
- the tip device 38 may have specific chemical sensitivities based upon the properties of a dye matrix.
- a dye may be chemically activated by a different chemical compound which enables sensing of a specific chemical property within a sample or a substance.
- the tip device 38 provides for enhanced sensitivity, selectivity, and stability when detecting a concentration within a sample or substance.
- the tip portion or device 38 may comprise a biologically active compound that is immobilized in an environment that is optically reactive. Additionally, the biologically active compound can, in itself, be optically active.
- the sensor device 10 interacts with the substance or sample to detect a specific chemical or concentration within the substance.
- the on/off switch 22 is pressed to initialize the device 10 .
- the device 10 may be inserted into a sample 80 to test for a particular concentration of material within the sample 80 .
- the sample to be tested is a liquid 82 in a beaker 84 .
- the tip portion 70 is inserted into the liquid 82 and at this point in time a beam of light, such as the beam of light 36 , is transmitted into the liquid 82 .
- the liquid 82 reacts chemically with the tip portion 70 and the color of the chemical composing the sensor device 10 changes.
- the color of the light reflected back into the tip portion 70 changes, such as reflected beam of light 40 , as compared to the beam of light 36 .
- the amount of this change can be quantified by the detector 42 . Once quantified signals are provided to the computer 44 which performs a calculation to determine the concentration of the particular chemical being sensed and the result may be displayed in the display 20 .
- the beam of light 32 is sent from the light source 30 through the fiber optic 34 which transmits the beam of light 36 through the tip device 38 into the liquid 82 .
- the reflected beam of light 40 is reflected from the liquid 82 into the tip device 38 to the detector 42 .
- the detector 42 provides signals to the computer 44 and the computer 44 determines the concentration of a particular chemical within the liquid 82 .
- This process may be termed photochemical optical fiber sensing.
- the chemical properties of the tip portion 70 of the sensor portion 14 may be changed to react with another chemical to detect some other chemical within a sample. Further, instead of changing the chemical properties of the tip portion 70 , it may only be necessary to change the light source 30 to detect some other chemical within a sample.
- FIG. 5 illustrates another preferred embodiment of a sensor device 100 which comprises a computer 102 which is connected to a light source 104 by a wire 106 .
- the light source 104 operates to provide light, represented by a light beam 108 , to be projected at an optical device 110 .
- the optical device 110 may be a mirror which allows light, which is represented by a light beam 112 , of a particular or predetermined wavelength or frequency to pass through the device 110 to be directed at a fiber optic 114 .
- the fiber optic 114 is connected to a connector device 116 and the fiber optic 114 passes light, such as light beam 118 , through to the connector device 116 .
- a beam of light 120 is transmitted from the connector device 116 to a sensor device 122 .
- the sensor device 122 is similar to the tip portion or device 38 which was shown in FIGS. 2 and 3 .
- Light such as light beam 124 , which may be reflected back from a sample (not shown) and through the sensor device 122 , is directed to the connector device 116 .
- a light beam 126 is transmitted from the connector device 116 to the fiber optic 114 .
- the fiber optic 114 in turn directs a light beam 128 to the optical device 110 .
- the optical device 110 provides a light beam 130 of a particular or predetermined wavelength or frequency to be directed at an optical detector device 132 .
- the optical detector 132 is connected by a wire 134 to the computer 102 and provides signals to the computer 102 .
- the computer 102 is operatively programmed to use the signals provided from the optical detector 132 to calculate or determine the concentration of a substance within a sample.
- the sensor device 100 is further shown comprising a pencil like body 150 which includes a central body portion 152 , an end cap 154 , and a tip portion 156 .
- the central body portion 152 has a display 158 for displaying information such as glucose concentration.
- An ON/OFF switch 160 is also included in the central body portion 152 for controlling operation of the sensor device 100 .
- the sensor device 100 is illustrated having the tip portion 156 inserted into a hand 162 of a patient. As has been previously discussed, the tip portion 156 is of an extremely small size and because of its small size insertion of the tip portion 156 into the hand 162 will produce little or no sensation.
- the other components of the sensor device 100 which were discussed with reference to FIG. 5, are all housed within the central body portion 152 .
- the tip portion 156 of the sensor device 100 is inserted into a sample, such as the hand 162 , to detect the presence of a concentration of material, such as for example glucose.
- a concentration of material such as for example glucose.
- the ON/OFF switch 160 is pressed by the user to initiate operation of the sensor device 100 .
- Actuation of the sensor device 100 causes the computer 102 to operate the light source 104 .
- the light beam 108 is sent to the optical device 110 which causes the light beam 112 to be directed at the fiber optic 114 which in turn produces the light beam 118 .
- the light beam 118 passes into the connector 116 and emerges as the light beam 120 which is provided to the sensor device 122 .
- the sensor device 122 reacts chemically with the hand 162 and the color of the chemical composing the sensor device 122 changes.
- the color of the light beam 124 which is reflected back into the sensor device 122 is then directed back into the connector 116 .
- the beam of light 126 is transmitted from the connector 116 to the fiber optic 114 which in turn transmits the beam of light 128 to the optical device 110 .
- the optical device allows the light beam 130 to be directed to the optical detector 134 .
- the optical detector 134 provides signals to the computer 102 which then determines the concentration of glucose within the hand 162 .
- the result may then be displayed in the display 158 of the sensor device 100 . Once the result is displayed, the user may remove the sensor device 100 from the hand 162 and press the ON/OFF switch 160 to turn the sensor device 100 off.
- the sensor device 100 may be used again to determine the glucose concentration.
- the sensor device 100 in actual construction is a small device and sized and shaped to be pencil like. Because of its small size the sensor device 100 may be used as a portable monitoring device. Additionally, the computer 102 may be a microprocessor chip, a customized integrated circuit chip such as an ASIC chip, or any other device which is capable of processing electrical signals. Although not shown or made reference to, a rechargeable battery or a replaceable battery may be used to power the sensor device 100 . Further both devices 10 and 100 may have incorporated therein a memory for storing information such as, for example, a log of monitoring of the patient's glucose concentration, time of day of monitoring, and date of monitoring.
- FIG. 7 depicts a block diagram of a third embodiment of a micro optical fiber sensor device 200 .
- the sensor device 200 comprises a computer 202 which is connected to a light source 204 via a wire 206 .
- the light source 204 projects a beam of light 208 into a section or portion of a fiber optic 210 .
- the fiber optic 210 is connected to a tip portion or device 212 and passes a beam of light 214 to the tip device 212 .
- the tip portion or device 212 is similar in several respects to the tip device 38 which was illustrated in FIGS. 2 and 3 , however, the tip device 212 is different in one respect. In fabricating the tip device 212 , as discussed in U.S. Pat. Nos.
- the tip device 212 uses a multi-dye matrix tip which is photochemically attached to the tip device 212 to form a multi-functional sensor having an extremely small size.
- the multi-dye configuration allows for a multi-function sensor in which each dye may be chemically activated by a different chemical compound. This enables the tip device 212 to sense, detect, or monitor more than one chemical.
- the tip device 212 is capable of monitoring two different chemicals, two different light beams, such as light beams 216 and 218 , will be reflected back from a sample and through the tip device 212 .
- Each of the light beams 216 and 218 are directed to a detector 220 and 222 , respectively.
- an optical component such as band pass filters, placed between the tip device 212 and the detectors 220 and 222 to direct the light beams 216 and 218 to a specific detector 220 or 222 .
- the detector 220 is connected to the computer 202 by a wire 224 and electrical signals indicative of the concentration of a particular chemical within a sample is provided to the computer 202 .
- the detector 222 is connected to the computer 202 by another wire 226 and signals indicative of another chemical within the sample are provided to the computer 202 .
- the computer 202 is programmed to receive the signals from the detectors 220 and 222 and calculate or determine the concentrations of the two chemicals within the sample.
- the sensor device 200 may include a display (not shown) which would display the results of the calculations.
- the sensor device 200 may also be provided with a power supply 228 which is operatively connected by a wire 230 to the computer 202 .
- the device 200 is depicted to show the monitoring of at least two different chemical compounds it is also contemplated that more than two chemical compounds may be sensed, detected, or monitored by the device 200 by adding additional components, as has been taught and illustrated.
- micro optical fiber sensor device which fulfills the various objects and advantages sought therefor. It will be apparent to those skilled in the art, however, that many changes, modifications, variations, and other uses and applications of the subject micro optical fiber sensor device are possible and contemplated. All changes, modifications, variations, and other uses and applications which do not depart from the spirit and scope of the invention are deemed to be covered by the invention, which is limited only by the claims which follow.
Abstract
A sensor device for measuring a concentration of a substance within a sample comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof, an optical detector for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light, and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
Description
- 1. This invention relates generally to a sensor device and more particularly to a micro optical fiber sensor device which may be employed in a variety of sensor applications to monitor, sense, or measure a concentration of a material within a sample.
- 2. There are numerous applications in which a device is used to monitor or detect a concentration of material within a substance. For example, it may be required to know the concentration of a chemical in a sample of material such as knowing the concentration of sodium, calcium, or some other chemical composition in a sample. Monitoring or detecting a concentration of a substance typically requires a set up of relatively complex, sensitive, and expensive equipment or instrumentation. Sometimes space requirements make it difficult to use the set up of complex equipment and it would be advantageous to have equipment which has small dimensions and is easily transportable. Additionally, such complex equipment may not provide results which are of a high resolution.
- 3. One known and important application for monitoring a concentration of a material within a sample deals with checking blood glucose for diabetics. There are at least two known techniques for monitoring blood glucose levels in humans. The two techniques are invasive which involves extracting samples with the use of needles or syringes and noninvasive. Typically, for the invasive method, a patient employs a small lancet device which is used to prick or puncture a finger. Blood is then collected onto a strip which has incorporated therein a chemical reagent. The strip is then placed inside of a device that optically reads the chemical reaction of the blood on the strip and converts this to a blood glucose level. It has been found very important to control glucose levels in diabetics to reduce any complications associated with diabetes. Many samples or finger pricks may be required to be taken for analysis during the course of a day. Self monitoring of blood glucose by a patient is therefor very important in the treatment of diabetes. Since finger pricking or lancing is required for self monitoring levels of glucose in a patient, many patients avoid this because it is painful and inconvenient. Therefore, a less invasive procedure would be desirable. The other methods, which have been termed noninvasive, typically involve a devices which uses near infrared light to detect blood glucose levels. These devices measure a glucose concentration in blood or an organism's tissue by use of an optical device without the need to collect blood or fracturing a part of the organism's tissue. Although these devices use noninvasive methods, in that no blood is collected, none of these devices have been commercially accepted or viable.
- 4. The present invention is designed to obviate and overcome many of the disadvantages and shortcomings associated with the prior use of complex testing and monitoring equipment. Additionally, the present invention is simple to use, provides extremely quick results and high resolution, and is easily transportable. The present invention uses relatively inexpensive components which results in a commercially viable product. Further, the micro optical fiber sensor device of the present invention is relatively noninvasive since it does not require the drawing of blood and provides immediate results which does not require related blood processing such as centrifugation, storage, transportation, and other time consuming testing.
- 5. The present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof, means for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light, and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
- 6. Another example of the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source for emitting a beam of light of a preselected wavelength with the light source being coupled to an optical device capable of transmitting the beam of light therethrough, the transmitted beam of light being directed into the first end of the sensor, through the sensor and out of the second end into a sample, the active material interacting with a substance within a sample to change the wavelength of the transmitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light from the second end, through the sensor, and out of the first end thereof, the optical device being further capable of reflecting the reflected beam of light, means for receiving the reflected beam of light which is reflected by the optical device for producing a signal indicative of the reflected beam of light; and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
- 7. A further example of the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and a first and a second active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the first active material capable of interacting with a first substance within a sample and the second active material capable of interacting with a second substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the first active material interacting with a first substance within a sample to change the wavelength of the emitted beam of light to produce a first reflected beam of light, the second active material interacting with a second substance within a sample to change the wavelength of the emitted beam of light to produce a second reflected beam of light, and the sensor for transmitting the first and second reflected beams of light out of the second end thereof, means for receiving the first and second reflected beams of light from the second end of the sensor for producing a first signal indicative of the first reflected beam of light and a second signal indicative of the second reflected beam of light, and a processor for receiving the first and second signals and for processing the first and second signals to determine the concentration of a first substance within a sample and the concentration of a second substance with a sample.
- 8. In light of the foregoing comments, it will be recognized that a principal object of the present invention is to provide an improved sensor device which is hand held, portable, and easy to operate.
- 9. Another object of the present invention is to provide a sensor device which has a tip portion of an extremely small size so that when it is inserted into a hand of a patient little or no sensation will be produced or detected.
- 10. A further object of the present invention is to provide a sensor device which is of simple construction and design and which can be easily employed with highly reliable results.
- 11. Another object of the present invention is to provide a sensor device which is accurate and provides readings in a short time span.
- 12. A still further object of the present invention is to provide a sensor device which is compact in design and is easily transportable for personal use.
- 13. These and other objects and advantages of the present invention will become apparent after considering the following detailed specification in conjunction with the accompanying drawings, wherein:
- 14.FIG. 1 is a perspective view of a micro optical fiber sensor device constructed according to the present invention;
- 15.FIG. 2 is a block diagram of the micro optical fiber sensor device constructed according to the present invention;
- 16.FIG. 3 is a perspective view of a tip portion of the micro optical fiber sensor device shown in FIG. 1;
- 17.FIG. 4 is a schematic view of the micro optical fiber sensor device of the present invention being employed to sense a concentration in a sample;
- 18.FIG. 5 is a block diagram of a second embodiment of the micro optical fiber sensor device constructed according to the present invention;
- 19.FIG. 6 is perspective view of the sensor device of FIG. 5 illustrated monitoring a concentration of glucose in a hand of a patient; and
- 20.FIG. 7 is a block diagram of a third embodiment of the micro optical fiber sensor device constructed according to the present invention.
- 21. Referring now to the drawings, wherein like numbers refer to like items,
number 10 identifies a preferred embodiment of a micro optical fiber sensor device constructed according to the present invention. As illustrated in FIG. 1, thedevice 10 comprises a pencil or pen shapedbody 12 which includes atip portion 14, acentral body portion 16, and anend cap 18. Thecentral body portion 16 further includes adisplay device 20, such as an LED (light emitting diode) type display or an LCD type display, for displaying information. Theend cap 18, which may be removable from thecentral body portion 16, is used to allow access into the interior of thecentral body portion 16. Batteries (not shown) can be inserted into thecentral body portion 16 to supply power to thedevice 10, as will be explained. Thecentral body portion 16 may also include an ON/OFF switch 22 which may be used to operate thedevice 10. Other switches (not shown) may be incorporated into thecentral body portion 16 to further control thedevice 10. Additionally, thecentral body portion 16 houses electronic circuitry and other components which will be illustrated and explained in further detail herein. Thedevice 10 is sized and shaped to be a hand held type device which is portable and preferably is the size and shape of a pencil or a pen. - 22. With reference now to FIG. 2, a block diagram of the circuitry and components of the
device 10 is shown. Thedevice 10 includes alight source 30 which may be an LED, a laser, a laser diode, or other excitation source. Thelight source 30 is adapted to project a beam of light 32 into asection fiber optic 34. Thefiber optic 34 transmits a beam of light 36 to a tip portion ordevice 38 which is part of thetip portion 14. The beam of light 36 passes through thetip device 38 and a reflected beam of light 40 can be reflected back from a sample (not shown) through thetip device 38 to adetector 42. The reflected beam oflight 40 typically has a wavelength or a frequency which is different than the wavelength or frequency of the beam oflight 36. Thedetector 42 is in turn connected to acomputer 44 via an electrical connection such as awire 46. Thedetector 42 provides electrical signals over thewire 46 to thecomputer 44. Thecomputer 44 may consists of, by way of examples, a microprocessor, a microcontroller, an ASIC chip, or any other known equivalent device which is capable of processing electrical signals. Thecomputer 44 is further operatively connected to apower supply 48, such as batteries, by awire 50. Thecomputer 44 may also connected to thedisplay device 20, theswitch 22, and thelight source 30 although such connection is not illustrated in FIG. 2. Additionally, thecomputer 44 may also be connected to other switches (not shown) which may be provided with thedevice 10. In this manner, the additional switches are used to further control or operate other functions of thedevice 10. - 23. The
tip device 38 is shown in greater detail in FIG. 3 and is preferably a small device on the order of microns in diameter. Thetip device 38 may be constructed as is disclosed in U.S. Pat. Nos. 5,361,314 and 5,627,922. In particular, thetip device 38 includes a non-taperedfiber optic portion 60 and a taperedfiber optic portion 62 which is coated with anopaque material 64. Thetip device 38 further includes afirst end 66 and asecond end 68. Thesecond end 68 further has a tip orportion 70 of material which is adhered thereto. Thetip 70 is chemically treated which enables thetip 70 to interact with the sample to be detected. Properties of the sensor ortip device 38 may vary dependent upon the sample and the chemical or substance to be detected by thedevice 10. As constructed, thetip device 38 allows for the beam of light 36 to pass through thefirst end 66, thesecond end 68, and thetip portion 70 and the reflectedbeam 40 is allowed to pass through thetip portion 70, thesecond end 68, and thefirst end 66. - 24. As indicated above, the
tip device 38 is extremely small on the order of one-thousandth the width of a human hair and because of this size it can be inserted through gaps in most cells or through the membrane of a cell without damaging the cell. Thetip 70 may be bathed in chemical coatings selected to react with biological compounds such as acid, calcium, oxygen, glucose, potassium, sodium, or any other material to be detected. The beam of light 36 which is transmitted through thetip device 38 glows with its brightness and color varying according to the concentration of the target chemical. Theportion 70 is a photochemical sensor which is less than ten microns in diameter. Again, theportion 70 is small enough that it can pass through the membrane of a cell to monitor the concentration and nature of chemicals within the cell. - 25. The
tip device 38 may have specific chemical sensitivities based upon the properties of a dye matrix. A dye may be chemically activated by a different chemical compound which enables sensing of a specific chemical property within a sample or a substance. Thetip device 38 provides for enhanced sensitivity, selectivity, and stability when detecting a concentration within a sample or substance. The tip portion ordevice 38 may comprise a biologically active compound that is immobilized in an environment that is optically reactive. Additionally, the biologically active compound can, in itself, be optically active. Thesensor device 10 interacts with the substance or sample to detect a specific chemical or concentration within the substance. - 26. With reference now to FIGS. 1, 2, and 4, the operation of the
device 10 will be explained in detail. In order to operate thedevice 10, the on/offswitch 22 is pressed to initialize thedevice 10. Once powered, thedevice 10 may be inserted into asample 80 to test for a particular concentration of material within thesample 80. As shown in FIG. 4, the sample to be tested is a liquid 82 in abeaker 84. Thetip portion 70 is inserted into the liquid 82 and at this point in time a beam of light, such as the beam oflight 36, is transmitted into the liquid 82. With thetip portion 70 being in contact with the liquid 82, the liquid 82 reacts chemically with thetip portion 70 and the color of the chemical composing thesensor device 10 changes. As a result of this change, the color of the light reflected back into thetip portion 70 changes, such as reflected beam oflight 40, as compared to the beam oflight 36. The amount of this change can be quantified by thedetector 42. Once quantified signals are provided to thecomputer 44 which performs a calculation to determine the concentration of the particular chemical being sensed and the result may be displayed in thedisplay 20. - 27. In further detail and again with reference to FIGS. 1, 2, and 4, once the
device 10 is actuated by pressing theswitch 22, the beam oflight 32 is sent from thelight source 30 through thefiber optic 34 which transmits the beam of light 36 through thetip device 38 into the liquid 82. The reflected beam oflight 40 is reflected from the liquid 82 into thetip device 38 to thedetector 42. Thedetector 42 provides signals to thecomputer 44 and thecomputer 44 determines the concentration of a particular chemical within the liquid 82. This process may be termed photochemical optical fiber sensing. Additionally, the chemical properties of thetip portion 70 of thesensor portion 14 may be changed to react with another chemical to detect some other chemical within a sample. Further, instead of changing the chemical properties of thetip portion 70, it may only be necessary to change thelight source 30 to detect some other chemical within a sample. - 28.FIG. 5 illustrates another preferred embodiment of a
sensor device 100 which comprises acomputer 102 which is connected to alight source 104 by awire 106. Thelight source 104 operates to provide light, represented by alight beam 108, to be projected at anoptical device 110. Theoptical device 110 may be a mirror which allows light, which is represented by alight beam 112, of a particular or predetermined wavelength or frequency to pass through thedevice 110 to be directed at afiber optic 114. Thefiber optic 114 is connected to aconnector device 116 and thefiber optic 114 passes light, such aslight beam 118, through to theconnector device 116. A beam oflight 120 is transmitted from theconnector device 116 to asensor device 122. Thesensor device 122 is similar to the tip portion ordevice 38 which was shown in FIGS. 2 and 3. Light, such aslight beam 124, which may be reflected back from a sample (not shown) and through thesensor device 122, is directed to theconnector device 116. Alight beam 126 is transmitted from theconnector device 116 to thefiber optic 114. Thefiber optic 114 in turn directs alight beam 128 to theoptical device 110. Theoptical device 110 provides alight beam 130 of a particular or predetermined wavelength or frequency to be directed at anoptical detector device 132. Theoptical detector 132 is connected by awire 134 to thecomputer 102 and provides signals to thecomputer 102. Thecomputer 102 is operatively programmed to use the signals provided from theoptical detector 132 to calculate or determine the concentration of a substance within a sample. - 29. Referring now to FIG. 6, the
sensor device 100 is further shown comprising a pencil likebody 150 which includes acentral body portion 152, anend cap 154, and atip portion 156. Thecentral body portion 152 has adisplay 158 for displaying information such as glucose concentration. An ON/OFF switch 160 is also included in thecentral body portion 152 for controlling operation of thesensor device 100. Thesensor device 100 is illustrated having thetip portion 156 inserted into ahand 162 of a patient. As has been previously discussed, thetip portion 156 is of an extremely small size and because of its small size insertion of thetip portion 156 into thehand 162 will produce little or no sensation. The other components of thesensor device 100, which were discussed with reference to FIG. 5, are all housed within thecentral body portion 152. - 30. With particular reference now to FIGS. 5 and 6, in operation, the
tip portion 156 of thesensor device 100 is inserted into a sample, such as thehand 162, to detect the presence of a concentration of material, such as for example glucose. Once inserted into thehand 162, the ON/OFF switch 160 is pressed by the user to initiate operation of thesensor device 100. Actuation of thesensor device 100 causes thecomputer 102 to operate thelight source 104. Thelight beam 108 is sent to theoptical device 110 which causes thelight beam 112 to be directed at thefiber optic 114 which in turn produces thelight beam 118. Thelight beam 118 passes into theconnector 116 and emerges as thelight beam 120 which is provided to thesensor device 122. With thesensor device 122 being in contact with thehand 162, thesensor device 122 reacts chemically with thehand 162 and the color of the chemical composing thesensor device 122 changes. The color of thelight beam 124 which is reflected back into thesensor device 122 is then directed back into theconnector 116. The beam oflight 126 is transmitted from theconnector 116 to thefiber optic 114 which in turn transmits the beam oflight 128 to theoptical device 110. The optical device allows thelight beam 130 to be directed to theoptical detector 134. Theoptical detector 134 provides signals to thecomputer 102 which then determines the concentration of glucose within thehand 162. The result may then be displayed in thedisplay 158 of thesensor device 100. Once the result is displayed, the user may remove thesensor device 100 from thehand 162 and press the ON/OFF switch 160 to turn thesensor device 100 off. Thesensor device 100 may be used again to determine the glucose concentration. - 31. The
sensor device 100 in actual construction is a small device and sized and shaped to be pencil like. Because of its small size thesensor device 100 may be used as a portable monitoring device. Additionally, thecomputer 102 may be a microprocessor chip, a customized integrated circuit chip such as an ASIC chip, or any other device which is capable of processing electrical signals. Although not shown or made reference to, a rechargeable battery or a replaceable battery may be used to power thesensor device 100. Further bothdevices - 32.FIG. 7 depicts a block diagram of a third embodiment of a micro optical
fiber sensor device 200. Thesensor device 200 comprises acomputer 202 which is connected to alight source 204 via awire 206. Thelight source 204 projects a beam oflight 208 into a section or portion of afiber optic 210. Thefiber optic 210 is connected to a tip portion ordevice 212 and passes a beam oflight 214 to thetip device 212. The tip portion ordevice 212 is similar in several respects to thetip device 38 which was illustrated in FIGS. 2 and 3, however, thetip device 212 is different in one respect. In fabricating thetip device 212, as discussed in U.S. Pat. Nos. 5,361,314 and 5,627,922, thetip device 212 uses a multi-dye matrix tip which is photochemically attached to thetip device 212 to form a multi-functional sensor having an extremely small size. The multi-dye configuration allows for a multi-function sensor in which each dye may be chemically activated by a different chemical compound. This enables thetip device 212 to sense, detect, or monitor more than one chemical. - 33. Since the
tip device 212 is capable of monitoring two different chemicals, two different light beams, such aslight beams tip device 212. Each of thelight beams detector tip device 212 and thedetectors light beams specific detector detector 220 is connected to thecomputer 202 by awire 224 and electrical signals indicative of the concentration of a particular chemical within a sample is provided to thecomputer 202. Additionally, thedetector 222 is connected to thecomputer 202 by anotherwire 226 and signals indicative of another chemical within the sample are provided to thecomputer 202. In this manner, thecomputer 202 is programmed to receive the signals from thedetectors sensor device 200 may include a display (not shown) which would display the results of the calculations. Thesensor device 200 may also be provided with apower supply 228 which is operatively connected by awire 230 to thecomputer 202. Although thedevice 200 is depicted to show the monitoring of at least two different chemical compounds it is also contemplated that more than two chemical compounds may be sensed, detected, or monitored by thedevice 200 by adding additional components, as has been taught and illustrated. - 34. From all that has been said, it will be clear that there has thus been shown and described herein a micro optical fiber sensor device which fulfills the various objects and advantages sought therefor. It will be apparent to those skilled in the art, however, that many changes, modifications, variations, and other uses and applications of the subject micro optical fiber sensor device are possible and contemplated. All changes, modifications, variations, and other uses and applications which do not depart from the spirit and scope of the invention are deemed to be covered by the invention, which is limited only by the claims which follow.
Claims (20)
1. A sensor device for measuring a concentration of a substance within a sample comprising:
a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample;
a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof;
means for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light; and
a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
2. The sensor device of wherein the active material is preselected to interact with a predetermined substance within a sample.
claim 1
3. The sensor device of wherein the reflected beam of light has a wavelength—which is different from the wavelength of the emitted beam of light.
claim 1
4. The sensor device of wherein the receiving means is an optical detector.
claim 1
5. The sensor device of wherein the concentration to be measured is glucose and the sample is a human.
claim 1
6. The sensor device of further comprising a pencil shaped and sized body having a tip portion, a central body, and an end cap.
claim 1
7. The sensor device of wherein the tip portion comprises a biologically active compound that is immobilized in an environment that is optically reactive.
claim 1
8. A sensor device for measuring a concentration of a substance within a sample comprising:
a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample;
a light source for emitting a beam of light of a preselected wavelength with the light source being coupled to an optical device capable of transmitting the beam of light therethrough, the transmitted beam of light being directed into the first end of the sensor, through the sensor, and out of the second end into a sample, the active material interacting with a substance within a sample to change the wavelength of the transmitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light from the second end, through the sensor, and out of the first end thereof, the optical device being further capable of reflecting the reflected beam of light;
means for receiving the reflected beam of light which is reflected by the optical device for producing a signal indicative of the reflected beam of light; and
a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
9. The sensor device of wherein the active material is preselected to interact with a predetermined substance within a sample.
claim 8
10. The sensor device of wherein the reflected beam of light has a wavelength which is different from the wavelength of the transmitted beam of light.
claim 8
11. The sensor device of wherein the receiving means is an optical detector.
claim 8
12. The sensor device of wherein the concentration to be measured is glucose and the sample is a human.
claim 8
13. The sensor device of further comprising a pencil shaped and sized body having a tip portion, a central body, and an end cap.
claim 8
14. The sensor device of wherein the tip portion comprises a biologically active compound that is immobilized in an environment that is optically reactive.
claim 8
15. A sensor device for measuring a concentration of a substance within a sample comprising:
a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and a first and a second active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the first active material capable of interacting with a first substance within a sample and the second active material capable of interacting with a second substance within a sample;
a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the first active material interacting with a first substance within a sample to change the wavelength of the emitted beam of light to produce a first reflected beam of light, the second active material interacting with a second substance within a sample to change the wavelength of the emitted beam of light to produce a second reflected beam of light, and the sensor for transmitting the first and second reflected beams of light out of the second end thereof;
means for receiving the first and second reflected beams of light from the second end of the sensor for producing a first signal indicative of the first reflected beam of light and a second signal indicative of the second reflected beam of light; and
a processor for receiving the first and second signals and for processing the first and second signals to determine the concentration of a first substance within a sample and the concentration of a second substance with a sample.
16. The sensor device of wherein the receiving means comprises a first means for receiving the first reflected beam of light and a second means for receiving the second beam of light.
claim 15
17. The sensor device of wherein the first means for receiving is an optical detector and the second means for receiving is an optical detector.
claim 16
18. The sensor device of wherein the first concentration to be measured is glucose and the sample is a human.
claim 15
19. The sensor device of further comprising a pencil shaped and sized body having a tip portion, a central body, and an end cap.
claim 15
20. The sensor device of wherein the tip portion comprises a biologically active compound that is immobilized in an environment that is optically reactive.
claim 15
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/729,611 US20010000129A1 (en) | 1998-06-19 | 2000-12-04 | Micro optical fiber sensor device |
US10/364,723 US6922576B2 (en) | 1998-06-19 | 2003-02-11 | Micro optical sensor device |
US11/166,344 US20060030761A1 (en) | 1998-06-19 | 2005-06-27 | Micro optical sensor device |
US11/745,324 US20070208237A1 (en) | 1998-06-19 | 2007-05-07 | Method of using a micro optical sensor device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/100,295 US6157442A (en) | 1998-06-19 | 1998-06-19 | Micro optical fiber sensor device |
US09/729,611 US20010000129A1 (en) | 1998-06-19 | 2000-12-04 | Micro optical fiber sensor device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/100,295 Continuation US6157442A (en) | 1998-06-19 | 1998-06-19 | Micro optical fiber sensor device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/364,723 Continuation-In-Part US6922576B2 (en) | 1998-06-19 | 2003-02-11 | Micro optical sensor device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20010000129A1 true US20010000129A1 (en) | 2001-04-05 |
Family
ID=22279062
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/100,295 Expired - Lifetime US6157442A (en) | 1998-06-19 | 1998-06-19 | Micro optical fiber sensor device |
US09/729,611 Abandoned US20010000129A1 (en) | 1998-06-19 | 2000-12-04 | Micro optical fiber sensor device |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/100,295 Expired - Lifetime US6157442A (en) | 1998-06-19 | 1998-06-19 | Micro optical fiber sensor device |
Country Status (1)
Country | Link |
---|---|
US (2) | US6157442A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070045126A1 (en) * | 2004-02-06 | 2007-03-01 | Beer Greg P | Oxidizable species as an internal reference for biosensors and method of use |
US20080145878A1 (en) * | 2004-12-13 | 2008-06-19 | Marfurt Karen L | Method of Differentiating Between Blood and Control Solutions Containing a Common Analyte |
US20090014339A1 (en) * | 2005-04-08 | 2009-01-15 | Beer Greg P | Oxidizable Species as an Internal Reference in Control Solutions for Biosensors |
US20090021743A1 (en) * | 2004-06-17 | 2009-01-22 | Dosmann Andrew J | Coaxial Diffuse Reflectance Read Head |
US20090148875A1 (en) * | 2007-12-10 | 2009-06-11 | Jing Lin | Control markers for auto-detection of control solution and method of use |
US20090305317A1 (en) * | 2008-06-05 | 2009-12-10 | Brauer Jacob S | User interface for testing device |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6922576B2 (en) * | 1998-06-19 | 2005-07-26 | Becton, Dickinson And Company | Micro optical sensor device |
US6535753B1 (en) * | 1998-08-20 | 2003-03-18 | Microsense International, Llc | Micro-invasive method for painless detection of analytes in extra-cellular space |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7699791B2 (en) | 2001-06-12 | 2010-04-20 | Pelikan Technologies, Inc. | Method and apparatus for improving success rate of blood yield from a fingerstick |
US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
CA2448902C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
DE60234597D1 (en) | 2001-06-12 | 2010-01-14 | Pelikan Technologies Inc | DEVICE AND METHOD FOR REMOVING BLOOD SAMPLES |
US7749174B2 (en) | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7033371B2 (en) | 2001-06-12 | 2006-04-25 | Pelikan Technologies, Inc. | Electric lancet actuator |
US20030077205A1 (en) * | 2001-10-24 | 2003-04-24 | Xu Tom C. | Diagnostic test optical fiber tips |
US6770883B2 (en) | 2002-01-30 | 2004-08-03 | Beckman Coulter, Inc. | Sample level detection system |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7993108B2 (en) | 2002-10-09 | 2011-08-09 | Abbott Diabetes Care Inc. | Variable volume, shape memory actuated insulin dispensing pump |
US7727181B2 (en) * | 2002-10-09 | 2010-06-01 | Abbott Diabetes Care Inc. | Fluid delivery device with autocalibration |
DE60336834D1 (en) | 2002-10-09 | 2011-06-01 | Abbott Diabetes Care Inc | FUEL FEEDING DEVICE, SYSTEM AND METHOD |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7579194B2 (en) * | 2003-01-30 | 2009-08-25 | Techelan, Llc | Apparatus and method for investigating chemical entities |
US7679407B2 (en) | 2003-04-28 | 2010-03-16 | Abbott Diabetes Care Inc. | Method and apparatus for providing peak detection circuitry for data communication systems |
ES2347248T3 (en) | 2003-05-30 | 2010-10-27 | Pelikan Technologies Inc. | PROCEDURE AND APPLIANCE FOR FLUID INJECTION. |
WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US7282101B2 (en) * | 2003-08-19 | 2007-10-16 | Mccurdy Brent K | Method for dissolving a solid material in a liquid |
WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US7787923B2 (en) * | 2003-11-26 | 2010-08-31 | Becton, Dickinson And Company | Fiber optic device for sensing analytes and method of making same |
US7496392B2 (en) * | 2003-11-26 | 2009-02-24 | Becton, Dickinson And Company | Fiber optic device for sensing analytes |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US20050185505A1 (en) * | 2004-02-19 | 2005-08-25 | Mccurdy Brent K. | Apparatus for dissolving a solid material in a liquid |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
CA2601441A1 (en) | 2005-03-21 | 2006-09-28 | Abbott Diabetes Care Inc. | Method and system for providing integrated medication infusion and analyte monitoring system |
US7768408B2 (en) | 2005-05-17 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing data management in data monitoring system |
US7620437B2 (en) | 2005-06-03 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and apparatus for providing rechargeable power in data monitoring and management systems |
US7756561B2 (en) | 2005-09-30 | 2010-07-13 | Abbott Diabetes Care Inc. | Method and apparatus for providing rechargeable power in data monitoring and management systems |
US7583190B2 (en) | 2005-10-31 | 2009-09-01 | Abbott Diabetes Care Inc. | Method and apparatus for providing data communication in data monitoring and management systems |
US8344966B2 (en) | 2006-01-31 | 2013-01-01 | Abbott Diabetes Care Inc. | Method and system for providing a fault tolerant display unit in an electronic device |
EP1998840A4 (en) | 2006-03-23 | 2012-02-29 | Becton Dickinson Co | System and methods for improved diabetes data management and use employing wireless connectivity between patients and healthcare providers and repository of diabetes management information |
US8579853B2 (en) | 2006-10-31 | 2013-11-12 | Abbott Diabetes Care Inc. | Infusion devices and methods |
US20090219509A1 (en) * | 2008-02-29 | 2009-09-03 | Hiroshi Nomura | Optical sensor with enhanced reflectance |
US8008068B2 (en) * | 2008-02-29 | 2011-08-30 | Light Pointe Medical, Inc. | Nonhemolytic optical sensor with enhanced reflectance |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US8560082B2 (en) | 2009-01-30 | 2013-10-15 | Abbott Diabetes Care Inc. | Computerized determination of insulin pump therapy parameters using real time and retrospective data processing |
WO2010129375A1 (en) | 2009-04-28 | 2010-11-11 | Abbott Diabetes Care Inc. | Closed loop blood glucose control algorithm analysis |
US8501111B2 (en) | 2009-05-21 | 2013-08-06 | Tom Cheng Xu | Small volume and fast acting optical analyte sensor |
EP2456351B1 (en) | 2009-07-23 | 2016-10-12 | Abbott Diabetes Care, Inc. | Real time management of data relating to physiological control of glucose levels |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
WO2015179288A1 (en) | 2014-05-19 | 2015-11-26 | University Of South Florida | Systems and methods for analyzing liquids |
EP3517938B1 (en) | 2018-01-30 | 2020-09-16 | Karlsruher Institut für Technologie | Optical detector and method for detection of a chemical compound |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5361314A (en) * | 1992-09-04 | 1994-11-01 | The Regents Of The University Of Michigan | Micro optical fiber light source and sensor and method of fabrication thereof |
US5448992A (en) * | 1992-12-10 | 1995-09-12 | Sunshine Medical Instruments, Inc. | Method and apparatus for non-invasive phase sensitive measurement of blood glucose concentration |
US5398681A (en) * | 1992-12-10 | 1995-03-21 | Sunshine Medical Instruments, Inc. | Pocket-type instrument for non-invasive measurement of blood glucose concentration |
US5341805A (en) * | 1993-04-06 | 1994-08-30 | Cedars-Sinai Medical Center | Glucose fluorescence monitor and method |
EP0670143B1 (en) * | 1993-08-12 | 2003-05-28 | Kurashiki Boseki Kabushiki Kaisha | Non invasive method and instrument for measuring blood sugar level |
US5553616A (en) * | 1993-11-30 | 1996-09-10 | Florida Institute Of Technology | Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator |
US5529755A (en) * | 1994-02-22 | 1996-06-25 | Minolta Co., Ltd. | Apparatus for measuring a glucose concentration |
US5553613A (en) * | 1994-08-17 | 1996-09-10 | Pfizer Inc. | Non invasive blood analyte sensor |
US5617852A (en) * | 1995-04-06 | 1997-04-08 | Macgregor; Alastair R. | Method and apparatus for non-invasively determining blood analytes |
-
1998
- 1998-06-19 US US09/100,295 patent/US6157442A/en not_active Expired - Lifetime
-
2000
- 2000-12-04 US US09/729,611 patent/US20010000129A1/en not_active Abandoned
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10067082B2 (en) | 2004-02-06 | 2018-09-04 | Ascensia Diabetes Care Holdings Ag | Biosensor for determining an analyte concentration |
US9410917B2 (en) | 2004-02-06 | 2016-08-09 | Ascensia Diabetes Care Holdings Ag | Method of using a biosensor |
US8696880B2 (en) | 2004-02-06 | 2014-04-15 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
US20070045126A1 (en) * | 2004-02-06 | 2007-03-01 | Beer Greg P | Oxidizable species as an internal reference for biosensors and method of use |
US7952716B2 (en) | 2004-06-17 | 2011-05-31 | Bayer Healthcare Llc | Coaxial diffuse reflectance read head |
US20090021743A1 (en) * | 2004-06-17 | 2009-01-22 | Dosmann Andrew J | Coaxial Diffuse Reflectance Read Head |
US7724374B2 (en) | 2004-06-17 | 2010-05-25 | Bayer Healthcare Llc | Coaxial diffuse reflectance read head |
US20100195109A1 (en) * | 2004-06-17 | 2010-08-05 | Bayer Healthcare Llc | Coaxial diffuse reflectance read head |
US8416398B2 (en) | 2004-12-13 | 2013-04-09 | Bayer Healthcare, Llc | Method of differentiating between blood and control solutions containing a common analyte |
US8681324B2 (en) | 2004-12-13 | 2014-03-25 | Bayer Healthcare, Llc | Method of differentiating between blood and control solutions containing a common analyte |
US8102517B2 (en) | 2004-12-13 | 2012-01-24 | Bayer Healthcare, Llc | Method of differentiating between blood and control solutions containing a common analyte |
US20080145878A1 (en) * | 2004-12-13 | 2008-06-19 | Marfurt Karen L | Method of Differentiating Between Blood and Control Solutions Containing a Common Analyte |
US9244078B2 (en) | 2005-04-08 | 2016-01-26 | Bayer Healthcare Llc | Oxidizable species as an internal reference in control solutions for biosensors |
US8702926B2 (en) | 2005-04-08 | 2014-04-22 | Bayer Healthcare Llc | Oxidizable species as an internal reference in control solutions for biosensors |
US8002965B2 (en) | 2005-04-08 | 2011-08-23 | Bayer Healthcare Llc | Oxidizable species as an internal reference in control solutions for biosensors |
US20090014339A1 (en) * | 2005-04-08 | 2009-01-15 | Beer Greg P | Oxidizable Species as an Internal Reference in Control Solutions for Biosensors |
US9766198B2 (en) | 2005-04-08 | 2017-09-19 | Ascensia Diabetes Care Holdings Ag | Oxidizable species as an internal reference in control solutions for biosensors |
US20090148875A1 (en) * | 2007-12-10 | 2009-06-11 | Jing Lin | Control markers for auto-detection of control solution and method of use |
US8716024B2 (en) | 2007-12-10 | 2014-05-06 | Bayer Healthcare Llc | Control solution for use in testing an electrochemical system |
US8871517B2 (en) | 2007-12-10 | 2014-10-28 | Bayer Healthcare Llc | Method of using a control solution and preparing for testing using the same |
US9933385B2 (en) | 2007-12-10 | 2018-04-03 | Ascensia Diabetes Care Holdings Ag | Method of using an electrochemical test sensor |
US8337691B2 (en) | 2007-12-10 | 2012-12-25 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and method of use |
US10690614B2 (en) | 2007-12-10 | 2020-06-23 | Ascensia Diabetes Care Holdings Ag | Method of using an electrochemical test sensor |
US20090305317A1 (en) * | 2008-06-05 | 2009-12-10 | Brauer Jacob S | User interface for testing device |
Also Published As
Publication number | Publication date |
---|---|
US6157442A (en) | 2000-12-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6157442A (en) | Micro optical fiber sensor device | |
US6922576B2 (en) | Micro optical sensor device | |
US6197257B1 (en) | Micro sensor device | |
US7731900B2 (en) | Body fluid testing device | |
JP4286226B2 (en) | Body fluid testing device | |
US4637403A (en) | Glucose medical monitoring system | |
US5507288A (en) | Analytical system for monitoring a substance to be analyzed in patient-blood | |
US7288073B2 (en) | System for withdrawing small amounts of body fluid | |
US7409238B2 (en) | Micro-invasive method for painless detection of analytes in extracellular space | |
US20080269575A1 (en) | Method and Apparatus for Monitoring Bodily Analytes | |
JP2009509667A (en) | Multi-part body fluid sampling and analysis cartridge | |
EP0631490A1 (en) | Blood chemistry measurement by stimulated infrared emission | |
WO2004110275A1 (en) | Device and method of measuring living-body information | |
Walt | Fiber-optic sensors for continuous clinical monitoring | |
KR20150050523A (en) | Noninvasive measurement of analyte concentration using a fiberless transflectance probe | |
KR20190052240A (en) | Potable optical non-invasive glucose detector and measurement strip |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: MICROSENSE INTERNATIONAL, LLC, MISSOURI Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:RASKAS, ERIC J.;REEL/FRAME:011353/0739 Effective date: 20001204 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: BECTON, DICKINSON AND COMPANY, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MICROSENSE INTERNATIONAL, L.L.C.;REEL/FRAME:015782/0801 Effective date: 20040115 |