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Publication numberUS1967927 A
Publication typeGrant
Publication date24 Jul 1934
Filing date4 Sep 1931
Priority date18 Jun 1931
Also published asDE603705C
Publication numberUS 1967927 A, US 1967927A, US-A-1967927, US1967927 A, US1967927A
InventorsDeutsch Desider
Original AssigneeFirm Schering Kahlbaum Ag
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Device for inserting medicaments into the body by iontophoresis
US 1967927 A
Abstract  available in
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Claims  available in
Description  (OCR text may contain errors)

Patented July 24, 1934 UNITED STATES DEVICE FOR INSERTING MEDICAMENTS INTO THE BODY BY IONTOPHORESIS Desider Deutsch, Budapest, Hungary, assignor to the firm Schering-Kahlbaum Aktiengesellschaft, Berlin, Germany No Drawing. Application September 4, 1931, Serial No. 561,312. In Germany June 17, 1931 3 Claims.

My invention relates to a device for inserting medicaments into the human or animal body by means of iontophoresis It is known to insert medicaments into the body by iontophoresis. To this end the medicament is put on the skin in fluid state and covered with an electrode connected to one pole of a direct current source while the other pole of said current source is connected to another electrode being in contact with any other part of the body. Thus the current flowing through the electrode and the medicament inserts the latter through the skin into the body. Instead of putting the medicament directly upon the skin it is also known to impregnate a pad of cotton-wool with the medicament and to lay this pad under the one electrode upon the skin. Both methods have several disadvantages. Owing to the poisonous effect of most medicaments if taken in greater quantities or stronger concentration than allowed, the physician must not give them into the hands of the patient but has to perform the iontophoresis himself. That is even true with the treatment of frequently appearing pains wanting repeated iontophoresis like rheumatism, so that the treatment is becoming very dear in spite of its simplicity and of the cheapness of the medicaments.

Moreover the known methods are very unthrifty even if performed by physicians, because usually there is put much more of the medicament upon the cotton-wool than necessary for one treatment and the surplus is getting lost since the same pad of cotton-wool can not be used another time. Besides it often happens that the patient gets burnt by the electric current if the electrode slides off from the wool-cotton and thus comes into direct contact with the skin.

One object of my invention is to provide means for performing the iontophoresis which can be used by everybody without danger of poisoning by the poisonous medicaments necessary therefor.

Another object is to provide a device for the said purpose by which the waste of medicaments is avoided. Another object is to prevent burning of the skin by the current.

My invention consists in a lining for the active electrode for the iontophoresis, said lining consisting of a material being impregnated with the necessary quantity of the medicament. This impregnated lining which may consist of filteringpaper, blotting-paper, textile fabric or the like can be given into the hand of the patient without scruple as wrong use of it is impossible so that the patient is thus enabled to cure his pains, for

example his rheumatism, himself. As the quantity of the medicament in the lining can be adjusted carefully there is no waste and each piece of the lining contains only as much of the medicament as necessary for one treatment. It is advantageous to mix the medicament with a disinfectant like thymol in order to prevent any decomposition of the medicament when storing for longer time. If the lining consists of the above named materials like paper or textile the water contained in the medicament will evaporate after the impregnation and the lining has to be moistened before use so as to make it conductive for the current. This is not necessary if the lining consists of hygroscopic material like hectograph-paste as in this case the lining remains damp permanently.

It is particularly advantageous to combine the lining with the electrode by providing it with a metallic covering serving as electrode. This covering may consist of a foil fastened to the lining or be produced on the lining by galvanoplastic depositing or by squirting. This combination of the lining with the electrode renders the performance of the iontophoresis very simple and easy, and makes it impossible to burn the patient since the electrode can never come into direct contact with the skin.

Having now particularly described and ascertained the nature of my said invention and in what manner the same is to be performed, I declare that what I claim is:

1. As an article of manufacture, for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly sufiicient for a single treatment, said lining being substantially free of water capable of evaporating therefrom.

2. As an article of manufacture, for use in a device for inserting medicaments into the human or animal body by iontophoresis, a lining for the active electrode, said lining being impregnated with a quantity of the medicament substantially exactly suflicient for a single treatment, and a thin flexible metallic covering secured to said lining and constituting the active electrode.

3. As an article of manufacture, for use in a device for inserting medicaments into the human thin flexible metallic covering secured to said lining and constituting the active electrode, said metallic covering comprising a galvanoplastic deposit.

DESIDER DEUTSCH.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US2784715 *25 Mar 195312 Mar 1957Kestler Otto ColmanCataphoresis unit
US4405311 *8 Dec 198020 Sep 1983Greatbatch Enterprises, Inc.Method and apparatus for direct electrical injection of gold ions into tissue such as bone
US4602909 *7 Feb 198329 Jul 1986Richter Gedeon Vegyeszeti Gyar RtVinca alkaloids
US4767401 *26 Aug 198230 Aug 1988Maurice SeidermanIontophoretic administration of ionizable or polar medicaments to a mammalian body
US5415629 *15 Sep 199316 May 1995Henley; Julian L.Programmable apparatus for the transdermal delivery of drugs and method
US625488327 Jan 19973 Jul 2001Novagent OyComposition for transdermal delivery of drugs
US673547018 Sep 200211 May 2004Biophoretic Therapeutic Systems, LlcElectrokinetic delivery of medicaments
US67923068 Apr 200214 Sep 2004Biophoretic Therapeutic Systems, LlcFinger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US689527126 Aug 200317 May 2005Biophoretic Therapeutic Systems, LlcIontophoretic drug delivery electrodes and method
US698927522 Mar 200224 Jan 2006Carnegie Mellon UniversityGenerating luminescent particles; generate reaction mixture containing biopolymers and cyanine dye, conjugate cyanine dye with biopolymer, evaluate signal from conjugate
US700879822 Mar 20027 Mar 2006Carnegie Mellon UniversityGenerating luminescent particle; obtain biopolymers, incubate with reaction mixture, recover labeled product
US70167241 Dec 200321 Mar 2006Transport Pharmaceuticals, Inc.Electrokinetic delivery system for self-administration of medicaments and methods therefor
US703176810 Jun 200218 Apr 2006Birch Point Medical, Inc.Controlled dosage drug delivery
US706907324 Mar 200427 Jun 2006Biophoretic Therapeutic Systems, LlcElectrokinetic delivery of medicaments
US71272857 Feb 200324 Oct 2006Transport Pharmaceuticals Inc.Systems and methods for electrokinetic delivery of a substance
US81978448 Jun 200712 Jun 2012Activatek, Inc.Active electrode for transdermal medicament administration
US832878811 May 201111 Dec 2012Nitric Biotherapeutics, Inc.Methods and systems for electrokinetic delivery of a substance
US835202413 Mar 20068 Jan 2013Nitric Biotherapeutics, Inc.Electrokinetic delivery system for self-administration of medicaments and methods therefor
DE3304246A1 *8 Feb 198318 Aug 1983Richter Gedeon VegyeszetIontophorese-zwischeneinlage, kontaktloesung und verwendung eines mikrotubulen-inhibitors zur behandlung von chronischen schmerz-syndromen
WO1997047353A1 *27 May 199718 Dec 1997Jouni HirvonenComposition and system for iontophoretic transdermal delivery of drugs
Classifications
U.S. Classification604/20
International ClassificationA61N1/30
Cooperative ClassificationA61N1/0448
European ClassificationA61N1/04E1I3