EP2143949A3 - Microfluidic system for controlled displacement of a liquid - Google Patents

Microfluidic system for controlled displacement of a liquid Download PDF

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Publication number
EP2143949A3
EP2143949A3 EP09164657.0A EP09164657A EP2143949A3 EP 2143949 A3 EP2143949 A3 EP 2143949A3 EP 09164657 A EP09164657 A EP 09164657A EP 2143949 A3 EP2143949 A3 EP 2143949A3
Authority
EP
European Patent Office
Prior art keywords
liquid
controlled displacement
interface
microfluidic system
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09164657.0A
Other languages
German (de)
French (fr)
Other versions
EP2143949A2 (en
Inventor
Jean-Maxime Roux
Raymond Campagnolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique et aux Energies Alternatives CEA filed Critical Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Publication of EP2143949A2 publication Critical patent/EP2143949A2/en
Publication of EP2143949A3 publication Critical patent/EP2143949A3/en
Withdrawn legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Abstract

L'invention concerne un dispositif microfluidique de déplacement contrôlé de liquide.The invention relates to a microfluidic device for the controlled displacement of liquid.

Le dispositif de déplacement contrôlé selon l'invention comporte un microcanal (10) rempli d'un premier liquide (F1) et d'un fluide (F2) formant une première interface (I1) avec le premier liquide (F1) , ou formant une première interface (I1) avec le premier liquide (F1) et une seconde interface (I3) avec un second liquide (F3) situé en aval dudit fluide (F2), et des moyens de déplacement du premier liquide (F1) par électromouillage.The controlled displacement device according to the invention comprises a microchannel (10) filled with a first liquid (F 1 ) and a fluid (F 2 ) forming a first interface (I 1 ) with the first liquid (F 1 ) , or forming a first interface (I 1 ) with the first liquid (F 1 ) and a second interface (I 3 ) with a second liquid (F 3 ) located downstream of said fluid (F 2 ), and means for moving the first liquid (F 1 ) by electrowetting.

Un système d'asservissement est prévu pour contrôler le déplacement du premier liquide (F1) en fonction de la position d'une interface (I1, I3) du fluide (F2).

Figure imgaf001
A servo system is provided to control the displacement of the first liquid (F 1 ) as a function of the position of an interface (I 1 , I 3 ) of the fluid (F 2 ).
Figure imgaf001
EP09164657.0A 2008-07-07 2009-07-06 Microfluidic system for controlled displacement of a liquid Withdrawn EP2143949A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0854597A FR2933316B1 (en) 2008-07-07 2008-07-07 MICROFLUID DEVICE FOR DISPLACING LIQUID CONTROL

Publications (2)

Publication Number Publication Date
EP2143949A2 EP2143949A2 (en) 2010-01-13
EP2143949A3 true EP2143949A3 (en) 2015-07-08

Family

ID=40521623

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09164657.0A Withdrawn EP2143949A3 (en) 2008-07-07 2009-07-06 Microfluidic system for controlled displacement of a liquid

Country Status (3)

Country Link
US (1) US8252159B2 (en)
EP (1) EP2143949A3 (en)
FR (1) FR2933316B1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007146025A2 (en) * 2006-06-06 2007-12-21 University Of Virginia Patent Foundation Capillary force actuator device and related method of applications
DE102010028012A1 (en) * 2010-04-21 2011-10-27 Qiagen Gmbh Liquid control for micro flow system
US8653832B2 (en) * 2010-07-06 2014-02-18 Sharp Kabushiki Kaisha Array element circuit and active matrix device
US20130293246A1 (en) * 2010-11-17 2013-11-07 Advanced Liquid Logic Inc. Capacitance Detection in a Droplet Actuator
WO2012085728A1 (en) * 2010-12-20 2012-06-28 Koninklijke Philips Electronics N.V. Microfluidic device with fluid flow control means
CN103597348B (en) 2012-02-29 2016-10-19 斯博科动力公司 Three-dimensional digital microfluidic system
US8764958B2 (en) * 2012-08-24 2014-07-01 Gary Chorng-Jyh Wang High-voltage microfluidic droplets actuation by low-voltage fabrication technologies
JP1628115S (en) * 2012-10-24 2019-04-01
US10369567B2 (en) * 2015-11-04 2019-08-06 International Business Machines Corporation Continuous, capacitance-based monitoring of liquid flows in a microfluidic device
CN109622085B (en) * 2019-01-31 2021-12-24 京东方科技集团股份有限公司 Driving method and device of micro-fluidic chip and micro-fluidic system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125138A1 (en) * 1999-05-18 2002-09-12 Gianni Medoro Method and apparatus for the manipulation of particles by means of dielectrophoresis
US20030006140A1 (en) * 2001-02-28 2003-01-09 Giacomo Vacca Microfluidic control using dielectric pumping
WO2006098700A1 (en) * 2005-03-18 2006-09-21 Nanyang Technological University Microfluidic sensor for interfacial tension measurement and method for measuring interfacial tension
WO2008055256A2 (en) * 2006-11-02 2008-05-08 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1997772A3 (en) * 2002-05-16 2011-01-26 Micronit Microfluidics B.V. Method of fabrication of a microfluidic device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125138A1 (en) * 1999-05-18 2002-09-12 Gianni Medoro Method and apparatus for the manipulation of particles by means of dielectrophoresis
US20030006140A1 (en) * 2001-02-28 2003-01-09 Giacomo Vacca Microfluidic control using dielectric pumping
WO2006098700A1 (en) * 2005-03-18 2006-09-21 Nanyang Technological University Microfluidic sensor for interfacial tension measurement and method for measuring interfacial tension
WO2008055256A2 (en) * 2006-11-02 2008-05-08 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REN H ET AL: "Automated on-chip droplet dispensing with volume control by electro-wetting actuation and capacitance metering", SENSORS AND ACTUATORS B: CHEMICAL: INTERNATIONAL JOURNAL DEVOTED TO RESEARCH AND DEVELOPMENT OF PHYSICAL AND CHEMICAL TRANSDUCERS, ELSEVIER S.A, CH, vol. 98, no. 2-3, 15 March 2004 (2004-03-15), pages 319 - 327, XP004493694, ISSN: 0925-4005, DOI: 10.1016/J.SNB.2003.09.030 *

Also Published As

Publication number Publication date
FR2933316A1 (en) 2010-01-08
US20100000866A1 (en) 2010-01-07
EP2143949A2 (en) 2010-01-13
US8252159B2 (en) 2012-08-28
FR2933316B1 (en) 2010-09-10

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