EP2076172A4 - Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same - Google Patents

Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same

Info

Publication number
EP2076172A4
EP2076172A4 EP07863628A EP07863628A EP2076172A4 EP 2076172 A4 EP2076172 A4 EP 2076172A4 EP 07863628 A EP07863628 A EP 07863628A EP 07863628 A EP07863628 A EP 07863628A EP 2076172 A4 EP2076172 A4 EP 2076172A4
Authority
EP
European Patent Office
Prior art keywords
techniques
same
therapeutic purposes
medical diagnostic
coherent raman
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07863628A
Other languages
German (de)
French (fr)
Other versions
EP2076172A2 (en
Inventor
Ian W Hunter
Shyamal Somaroo
Serge Lafontaine
Patrick A Anquetil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aretais Inc
Original Assignee
Aretais Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aretais Inc filed Critical Aretais Inc
Publication of EP2076172A2 publication Critical patent/EP2076172A2/en
Publication of EP2076172A4 publication Critical patent/EP2076172A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G01N21/276—Calibration, base line adjustment, drift correction with alternation of sample and standard in optical path
EP07863628A 2006-10-27 2007-10-29 Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same Withdrawn EP2076172A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85503206P 2006-10-27 2006-10-27
US85503306P 2006-10-27 2006-10-27
PCT/US2007/082905 WO2008052221A2 (en) 2006-10-27 2007-10-29 Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same

Publications (2)

Publication Number Publication Date
EP2076172A2 EP2076172A2 (en) 2009-07-08
EP2076172A4 true EP2076172A4 (en) 2012-03-21

Family

ID=39325500

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07863628A Withdrawn EP2076172A4 (en) 2006-10-27 2007-10-29 Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same

Country Status (3)

Country Link
US (1) US20080117416A1 (en)
EP (1) EP2076172A4 (en)
WO (1) WO2008052221A2 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8253936B2 (en) 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
WO2008127388A2 (en) * 2006-10-27 2008-10-23 Aretais, Inc. Use of quantum system identification and quantum control techniques for medical diagnostic and therapeutic purposes
WO2009012222A1 (en) 2007-07-13 2009-01-22 Purdue Research Foundation Time-resolved raman spectroscopy
WO2009137740A1 (en) * 2008-05-09 2009-11-12 Hugh Beckman Medical device for diagnosing and treating anomalous tissue and method for doing the same
WO2009149733A1 (en) * 2008-06-13 2009-12-17 Embl Heidelberg Next generation flow cytometer sorter
KR100973149B1 (en) * 2008-09-05 2010-07-30 한국표준과학연구원 Spectrally Encoded CARS Endoscope
WO2010095263A1 (en) * 2009-02-23 2010-08-26 オリンパス株式会社 Laser microscope
EP2416708B1 (en) * 2009-04-01 2019-05-08 Erasmus University Medical Center Rotterdam Method for determination of one or more mutations
GB201000179D0 (en) 2010-01-07 2010-02-24 Rsp Systems As Apparatus for non-invasive in vivo measurement by raman spectroscopy
US20120010513A1 (en) * 2010-07-08 2012-01-12 Wong Stephen T C Chemically-selective, label free, microendoscopic system based on coherent anti-stokes raman scattering and microelectromechanical fiber optic probe
WO2012006625A2 (en) 2010-07-09 2012-01-12 Velomedix, Inc. Method and apparatus for pressure measurement
EP2439536A1 (en) * 2010-10-01 2012-04-11 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO New classification method for spectral data
FR2969282B1 (en) * 2010-12-21 2014-07-18 Horiba Jobin Yvon Sas DEVICE AND METHOD FOR VISUALIZING AND MEASURING RAMAN DIFFUSION
US20140058226A1 (en) * 2010-12-22 2014-02-27 Boris M. Chernobrod Method and Apparatus for In Vivo Optical Measurement of Blood Glucose Concentration
US10194805B2 (en) * 2011-02-05 2019-02-05 Triple Ring Technologies, Inc. Intrinsic and swept-source raman spectroscopy
US9655555B2 (en) 2011-03-07 2017-05-23 Potrero Medical, Inc. Sensing foley catheter
WO2012134515A1 (en) * 2011-04-01 2012-10-04 Verifica-Bg Inc. Method and apparatus for in vivo optical measurement of blood glucose concentration
US20130052636A1 (en) * 2011-08-22 2013-02-28 Spectral Platforms, Inc. Rapid detection of metabolic activity
WO2013032839A2 (en) * 2011-09-02 2013-03-07 The Board Of Trustees Of The Leland Stanford Junior University Raman imaging devices and methods of moleclar imaging
WO2013118124A1 (en) * 2012-02-08 2013-08-15 Biop Imaging, Ltd. Method and apparatus for tissue disease diagnosis
EP2917734A4 (en) * 2012-11-06 2016-09-07 Chemimage Corp System and method for serum based cancer detection
AU2014261003B2 (en) 2013-05-02 2019-03-28 Atonarp Inc. Monitor and system for monitoring living organisms
AU2015204868B2 (en) 2014-01-07 2019-05-16 Potrero Medical, Inc. Systems, devices and methods for draining and analyzing bodily fluids
CZ2014184A3 (en) * 2014-03-26 2015-08-26 Tescan Orsay Holding, A.S. Analytic system with Raman microscope and electron microscope
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
CA2953527A1 (en) * 2014-05-30 2015-12-03 Todd Frank OVOKAITYS Method and system for generation and use of activated stem cells
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
GB201415671D0 (en) 2014-09-04 2014-10-22 Systems Rsp As Method and apparatus for transdermal in vivo measurement by raman spectroscopy
SG11201701818YA (en) 2014-09-28 2017-04-27 Potrero Medical Inc Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids
KR102395773B1 (en) * 2014-11-07 2022-05-09 삼성전자주식회사 Spectroscopy system for biological material and spectroscopy method using the spectroscopy system
KR102335739B1 (en) 2014-12-19 2021-12-06 삼성전자주식회사 Apparatus and method for measuring a blood glucose in a noninvasive manner
WO2016157156A1 (en) 2015-04-02 2016-10-06 Livspek Medical Technologies Inc. Method and apparatus for a spectral detector for noninvasive detection and monitoring of a variety of biomarkers and other blood constituents in the conjunctiva
EP3347691B1 (en) 2015-09-11 2022-01-12 Leibniz-Institut für Photonische Technologien e.V. Arrangement for an individualized patient blood analysis and use
DE102015115342A1 (en) 2015-09-11 2017-03-16 Leibniz-Institut für Photonische Technologien e. V. Arrangement of individualized patient blood analysis
US10391275B2 (en) 2015-11-17 2019-08-27 Potrero Medical, Inc. Systems, devices and methods for draining and analyzing bodily fluids
EP3474001B1 (en) * 2016-06-17 2021-11-17 Saitama Medical University Test object visualizing device
KR101716729B1 (en) * 2016-09-27 2017-03-27 주식회사 토브스 Apparatus and method for analyzing saliva and system and method for monitoring animal using the apparatus
JP2019035669A (en) * 2017-08-16 2019-03-07 株式会社ニコン Observation apparatus and observation method
RU2020109417A (en) * 2017-08-24 2021-09-24 Штайнфурт Месс-Зистеме Гмбх METHOD OF EXAMINATION IN PACKAGES
US10620050B2 (en) * 2018-03-05 2020-04-14 Ut-Battelle, Llc Vibrational sum frequency generation using shaped near infrared light
JPWO2020203969A1 (en) * 2019-04-03 2020-10-08
DE102021102601A1 (en) 2021-02-04 2022-08-04 Friedrich-Schiller-Universität Jena Method for analyzing changes in signatures of key metabolites in biological samples
WO2022220012A1 (en) * 2021-04-13 2022-10-20 アトナープ株式会社 Implant, biomonitoring system, and biomanagement system
WO2024052898A1 (en) * 2022-09-06 2024-03-14 Refana Inc. System and method for non-invasive quantification of blood biomarkers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5850623A (en) * 1997-03-14 1998-12-15 Eastman Chemical Company Method for standardizing raman spectrometers to obtain stable and transferable calibrations
US20040127777A1 (en) * 2001-01-26 2004-07-01 Ruchti Timothy L. Indirect measurement of tissue analytes through tissue properties

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277760A (en) * 1979-03-30 1981-07-07 United Technologies Corporation Crossed-beam phase-matched coherent anti-stokes raman spectroscopy
US4405237A (en) * 1981-02-04 1983-09-20 The United States Of America As Represented By The Secretary Of The Navy Coherent anti-Stokes Raman device
US4509522A (en) * 1981-12-15 1985-04-09 The United States Of America As Represented By The Secretary Of The Navy Infrared optical measurement of blood gas concentrations and fiber optic catheter
US4512660A (en) * 1983-04-14 1985-04-23 The United States Of America As Represented By The Secretary Of The Navy Picosecond broadband cars probe using the picosecond continuum
DK230183D0 (en) * 1983-05-24 1983-05-24 Radiometer As ELECTRIC DEVICE FOR APPLICATION ON A SKIN SURFACE
US4940659A (en) * 1987-02-20 1990-07-10 Monoclonetics International, Inc. Screening extra-cellular body fluids for superoxide dismutase (SOD-1) for determining fetal trisomy 21 down syndrome
EP0409956B2 (en) * 1989-01-17 2004-07-21 MACRI, James N. Down syndrome screening method
US5068536A (en) * 1989-01-19 1991-11-26 Futrex, Inc. Method for providing custom calibration for near infrared instruments for measurement of blood glucose
US4975581A (en) * 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
US5641628A (en) * 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5355880A (en) * 1992-07-06 1994-10-18 Sandia Corporation Reliable noninvasive measurement of blood gases
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
AU7828694A (en) * 1993-08-24 1995-03-22 Mark R. Robinson A robust accurate non-invasive analyte monitor
US5553616A (en) * 1993-11-30 1996-09-10 Florida Institute Of Technology Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator
US5617850A (en) * 1994-03-24 1997-04-08 Gold Standard Medical Corp. Gas probe
US5602038A (en) * 1994-07-25 1997-02-11 Private Clinic Laboratories, Inc. Method of determining renal clearances
US5800361A (en) * 1995-02-06 1998-09-01 Ntc Technology Inc. Non-invasive estimation of arterial blood gases
US6627404B1 (en) * 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US7016713B2 (en) * 1995-08-09 2006-03-21 Inlight Solutions, Inc. Non-invasive determination of direction and rate of change of an analyte
US5882301A (en) * 1995-12-13 1999-03-16 Yoshida; Akitoshi Measuring apparatus for intraocular substance employing light from eyeball
US6040906A (en) * 1996-07-11 2000-03-21 Harhay; Gregory P. Resonance raman spectroscopy for identifying and quantitating biomatter, organic, and inorganic analytes
WO1998003010A2 (en) * 1996-07-15 1998-01-22 Pacific Title And Mirage, Inc. Rapid high resolution image capture system
US5722396A (en) * 1996-08-13 1998-03-03 St. Luke's-Roosevelt Hospital Center Method for estimating creatinine clearance using measurements of body cell mass
WO1999004246A1 (en) * 1997-07-14 1999-01-28 Massachusetts Institute Of Technology Three-dimensional light absorption spectroscopic imaging
US6005664A (en) * 1997-10-07 1999-12-21 Massachusetts Institute Of Technology Nonuniform sampling for spectral and related applications
ATE352252T1 (en) * 1997-11-12 2007-02-15 Lightouch Medical Inc METHOD FOR NON-INVASIVE ANALYTE MEASUREMENT
US6101269A (en) * 1997-12-19 2000-08-08 Lifef/X Networks, Inc. Apparatus and method for rapid 3D image parametrization
US6489138B1 (en) * 1998-01-14 2002-12-03 Human Genome Sciences, Inc. Human ependymin
US6560478B1 (en) * 1998-03-16 2003-05-06 The Research Foundation Of City University Of New York Method and system for examining biological materials using low power CW excitation Raman spectroscopy
US6151522A (en) * 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
US6327068B1 (en) * 1998-05-27 2001-12-04 Yeda Research And Development Co. Ltd. Adaptive pulse compressor
ATE225142T1 (en) * 1998-07-07 2002-10-15 Lightouch Medical Inc TISSUE MODULATION METHOD FOR QUANTITATIVE NON-INVASIVE IN VIVO SPECTROSCOPIC ANALYSIS OF TISSUE
US6108081A (en) * 1998-07-20 2000-08-22 Battelle Memorial Institute Nonlinear vibrational microscopy
IL126426A0 (en) * 1998-09-29 1999-05-09 Technion Res & Dev Foundation Process for the preparation of corroles several such new compounds including chiral derivatives and the use thereof
US6352502B1 (en) * 1998-12-03 2002-03-05 Lightouch Medical, Inc. Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities
US6167290A (en) * 1999-02-03 2000-12-26 Bayspec, Inc. Method and apparatus of non-invasive measurement of human/animal blood glucose and other metabolites
ATE543080T1 (en) * 2000-07-13 2012-02-15 Harvard College SYSTEM AND METHOD FOR EPIDETECTION COHERENCE ANTI-STOKES RAMAN SCATTERING MICROSCOPY
US20040005555A1 (en) * 2000-08-31 2004-01-08 Rothman Richard E. Molecular diagnosis of bactermia
US20040063216A1 (en) * 2000-12-24 2004-04-01 Iser Lubocki Method for detecting biomarkers
US7139598B2 (en) * 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
US7217266B2 (en) * 2001-05-30 2007-05-15 Anderson R Rox Apparatus and method for laser treatment with spectroscopic feedback
WO2003004983A1 (en) * 2001-07-03 2003-01-16 President And Fellows Of Harvard College System and method for polarization coherent anti-stokes raman scattering microscopy
US7262017B2 (en) * 2001-09-14 2007-08-28 Torrey Pines Institute For Molecular Studies Diagnostic markers for ischemia
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6795777B1 (en) * 2002-03-04 2004-09-21 The Texas A&M University System Identifying molecules of a sample
US20050240311A1 (en) * 2002-03-04 2005-10-27 Herschel Rabitz Closed-loop apparatuses for non linear system identification via optimal control
US20040180379A1 (en) * 2002-08-30 2004-09-16 Northwestern University Surface-enhanced raman nanobiosensor
AU2003272279B2 (en) * 2002-09-06 2007-04-26 Massachusetts Institute Of Technology Measuring properties of an anatomical body
DE10243449B4 (en) * 2002-09-19 2014-02-20 Leica Microsystems Cms Gmbh CARS microscope and method for CARS microscopy
US20040128081A1 (en) * 2002-12-18 2004-07-01 Herschel Rabitz Quantum dynamic discriminator for molecular agents
US7256885B2 (en) * 2003-01-29 2007-08-14 Yeda Research And Development Company Ltd. Coherently controlled nonlinear Raman spectroscopy and microscopy
US20040197832A1 (en) * 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
US6949070B2 (en) * 2003-08-21 2005-09-27 Ishler Larry W Non-invasive blood glucose monitoring system
BRPI0415411A (en) * 2003-10-17 2006-12-05 Koninkl Philips Electronics Nv spectroscopic method and system for determining a property of a substance, and, computer program product
JP4796967B2 (en) * 2003-11-07 2011-10-19 ヴァーミリオン インコーポレイテッド Biomarkers for Alzheimer's disease
WO2005072133A2 (en) * 2004-01-27 2005-08-11 Zoragen, Inc. Nucleic acid detection
US20050230239A1 (en) * 2004-03-12 2005-10-20 Herschel Rabitz Accelerating the discovery of effective photonic reagents
CA2563996A1 (en) * 2004-04-23 2005-11-10 Renal Diagnostic, Inc. An automated non- invasive real-time acute renal failure detection system
US7388668B2 (en) * 2004-06-09 2008-06-17 President & Fellows Of Harvard College Phase sensitive heterodyne coherent anti-Stokes Raman scattering micro-spectroscopy and microscopy
WO2006091835A2 (en) * 2005-02-25 2006-08-31 The Trustees Of Princeton University Optimal dynamic discrimination of similar molecular scale systems using functional data
WO2006116637A2 (en) * 2005-04-27 2006-11-02 Massachusetts Institute Of Technology Raman spectroscopy for non-invasive glucose measurements
US7414729B2 (en) * 2005-10-13 2008-08-19 President And Fellows Of Harvard College System and method for coherent anti-Stokes Raman scattering endoscopy
US7573577B2 (en) * 2005-10-21 2009-08-11 Southwest Research Institute Spatial heterodyne wide-field Coherent Anti-Stokes Raman spectromicroscopy
US7352458B2 (en) * 2005-10-26 2008-04-01 President And Fellows Of Harvard College System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses
JP2009529887A (en) * 2006-03-13 2009-08-27 イコニシス インコーポレーテッド Non-invasive methods for diagnosing fetal and cancer cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5850623A (en) * 1997-03-14 1998-12-15 Eastman Chemical Company Method for standardizing raman spectrometers to obtain stable and transferable calibrations
US20040127777A1 (en) * 2001-01-26 2004-07-01 Ruchti Timothy L. Indirect measurement of tissue analytes through tissue properties

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANNIKA M. K. ENEJDER ET AL: "Raman spectroscopy for noninvasive glucose measurements", JOURNAL OF BIOMEDICAL OPTICS, vol. 10, no. 3, 1 January 2005 (2005-01-01), pages 031114, XP055018261, ISSN: 1083-3668, DOI: 10.1117/1.1920212 *
BERGER A J ET AL: "Feasibility of measuring blood glucose concentration by near-infrared Raman spectroscopy", SPECTROCHIMICA ACTA. PART A: MOLECULAR SPECTROSCOPY, PERGAMON PRESS, OXFORD, GB, vol. 53A, no. 2, 1 February 1997 (1997-02-01), pages 287 - 292, XP002400213, ISSN: 0584-8539, DOI: 10.1016/S0584-8539(96)01779-5 *
JOSEPH CHAIKEN ET AL: "Effect of hemoglobin concentration variation on the accuracy and precision of glucose analysis using tissue modulated, noninvasive, in vivo Raman spectroscopy of human blood: a small clinical study", JOURNAL OF BIOMEDICAL OPTICS, vol. 10, no. 3, 1 January 2005 (2005-01-01), pages 031111, XP055018262, ISSN: 1083-3668, DOI: 10.1117/1.1922147 *
OMAR S. KHALIL: "Non-Invasive Glucose Measurement Technologies: An Update from 1999 to the Dawn of the New Millennium", DIABETES TECHNOLOGY & THERAPEUTICS, vol. 6, no. 5, 1 October 2004 (2004-10-01), pages 660 - 697, XP055018258, ISSN: 1520-9156, DOI: 10.1089/dia.2004.6.660 *

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Publication number Publication date
EP2076172A2 (en) 2009-07-08
WO2008052221A3 (en) 2008-08-28
WO2008052221A9 (en) 2008-06-26
US20080117416A1 (en) 2008-05-22
WO2008052221A2 (en) 2008-05-02

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