EP1497314A4 - Compositions and methods of use of targeting peptides against placenta and adipose tissues - Google Patents

Compositions and methods of use of targeting peptides against placenta and adipose tissues

Info

Publication number
EP1497314A4
EP1497314A4 EP02757531A EP02757531A EP1497314A4 EP 1497314 A4 EP1497314 A4 EP 1497314A4 EP 02757531 A EP02757531 A EP 02757531A EP 02757531 A EP02757531 A EP 02757531A EP 1497314 A4 EP1497314 A4 EP 1497314A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
adipose tissues
targeting peptides
peptides against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02757531A
Other languages
German (de)
French (fr)
Other versions
EP1497314A2 (en
Inventor
Renata Pasqualini
Wadih Arap
Mikhail G Kolonin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/027692 external-priority patent/WO2002020769A1/en
Application filed by University of Texas System filed Critical University of Texas System
Publication of EP1497314A2 publication Critical patent/EP1497314A2/en
Publication of EP1497314A4 publication Critical patent/EP1497314A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/28—Gramicidins A, B, D; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
EP02757531A 2001-09-07 2002-08-30 Compositions and methods of use of targeting peptides against placenta and adipose tissues Withdrawn EP1497314A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/US01/27692 2001-09-07
PCT/US2001/027692 WO2002020769A1 (en) 2000-09-08 2001-09-07 Human and mouse targeting peptides identified by phage display
PCT/US2002/027836 WO2003022991A2 (en) 2001-09-07 2002-08-30 Compositions and methods of use of targeting peptides against placenta and adipose tissues

Publications (2)

Publication Number Publication Date
EP1497314A2 EP1497314A2 (en) 2005-01-19
EP1497314A4 true EP1497314A4 (en) 2007-10-10

Family

ID=21742817

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02757531A Withdrawn EP1497314A4 (en) 2001-09-07 2002-08-30 Compositions and methods of use of targeting peptides against placenta and adipose tissues

Country Status (4)

Country Link
EP (1) EP1497314A4 (en)
AU (1) AU2002323543A1 (en)
CA (1) CA2458047A1 (en)
WO (1) WO2003022991A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148277A (en) * 2014-11-03 2017-09-08 清华大学 A kind of medicine for suppressing Adipocyte Differentiation and insulin resistant

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US8507445B2 (en) 2001-09-07 2013-08-13 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US7671010B2 (en) 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
WO2005041882A2 (en) * 2003-10-31 2005-05-12 The Burnham Institute Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
US20050191294A1 (en) * 2003-12-31 2005-09-01 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
WO2007020405A2 (en) * 2005-08-12 2007-02-22 Cartela R & D Ab Integrin i-domain binding peptides
CA2827029C (en) 2011-02-11 2019-07-02 The Regents Of The University Of Michigan Tripeptide compositions and methods
CN114469891B (en) * 2021-12-29 2023-01-24 中山大学附属第一医院 Micromolecule drug/therapeutic gene combined delivery system with enzyme sensitive shell and preparation method and application thereof
CN114272390B (en) * 2021-12-29 2022-09-02 中山大学附属第一医院 Microenvironment targeted combined cell targeted tumor inhibition carrier and preparation method and application thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
WO1998039469A1 (en) * 1997-03-04 1998-09-11 Bio-Technology General Corp. Isolation of tissue specific peptide ligands and their use for targeting pharmaceuticals to organs
WO1999004813A1 (en) * 1997-07-24 1999-02-04 Brigham & Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
WO2001013114A1 (en) * 1999-08-16 2001-02-22 Bio-Rad Pasteur Use of stabilised synthetic compounds in immunoassay
WO2001042276A1 (en) * 1999-12-13 2001-06-14 Proteom Limited Complementary peptide ligands generated from higher eukaryote genome sequences
WO2001053342A1 (en) * 2000-01-21 2001-07-26 The Burnham Institute Chimeric prostate-homing peptides with pro-apoptotic activity
WO2002020769A1 (en) * 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Human and mouse targeting peptides identified by phage display

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19605175A1 (en) * 1996-02-13 1997-08-14 Sourovoi Andrej Dr Lipid compounds and their use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
WO1998039469A1 (en) * 1997-03-04 1998-09-11 Bio-Technology General Corp. Isolation of tissue specific peptide ligands and their use for targeting pharmaceuticals to organs
WO1999004813A1 (en) * 1997-07-24 1999-02-04 Brigham & Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
WO2001013114A1 (en) * 1999-08-16 2001-02-22 Bio-Rad Pasteur Use of stabilised synthetic compounds in immunoassay
WO2001042276A1 (en) * 1999-12-13 2001-06-14 Proteom Limited Complementary peptide ligands generated from higher eukaryote genome sequences
WO2001053342A1 (en) * 2000-01-21 2001-07-26 The Burnham Institute Chimeric prostate-homing peptides with pro-apoptotic activity
WO2002020769A1 (en) * 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Human and mouse targeting peptides identified by phage display

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HUSSAIN MUNIR A ET AL: "Nasal mucosal metabolism and absorption of pentapeptide enkephalin analogs having varying N-terminal amino acids", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 84, no. 1, 1995, pages 62 - 64, XP002447983, ISSN: 0022-3549 *
KOLONIN M G ET AL: "Reversal of obesity by targeted ablation of adipose tissue", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 10, no. 6, June 2004 (2004-06-01), pages 625 - 632, XP002363820, ISSN: 1078-8956 *
KOLONIN MIKHAIL G ET AL: "Teratogenicity induced by targeting a placental immunoglobulin transporter", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 20, 1 October 2002 (2002-10-01), pages 13055 - 13060, XP002433168, ISSN: 0027-8424 *
KOLONIN MIKHAIL GERMAN ET AL: "Targeting physiological and pathological blood vessel formation with in vivo phage display", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 42, March 2001 (2001-03-01), & 92ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LA, USA; MARCH 24-28, 2001, pages 822 - 823, XP001536410, ISSN: 0197-016X *
NOMIZU ET AL.: "Cell binding sequences in mouse laminin alpha1 chain", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 1998, pages 32491 - 32499, XP002447984 *
ST HILAIRE P M ET AL: "The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach.", CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 18 AUG 2000, vol. 1, no. 2, 18 August 2000 (2000-08-18), pages 115 - 122, XP002433167, ISSN: 1439-4227 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148277A (en) * 2014-11-03 2017-09-08 清华大学 A kind of medicine for suppressing Adipocyte Differentiation and insulin resistant

Also Published As

Publication number Publication date
AU2002323543A1 (en) 2003-03-24
WO2003022991A3 (en) 2004-10-28
EP1497314A2 (en) 2005-01-19
CA2458047A1 (en) 2003-03-20
WO2003022991A2 (en) 2003-03-20

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Legal Events

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AX Request for extension of the european patent

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Effective date: 20070912

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