EP1276426A4 - Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems - Google Patents

Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems

Info

Publication number
EP1276426A4
EP1276426A4 EP01918390A EP01918390A EP1276426A4 EP 1276426 A4 EP1276426 A4 EP 1276426A4 EP 01918390 A EP01918390 A EP 01918390A EP 01918390 A EP01918390 A EP 01918390A EP 1276426 A4 EP1276426 A4 EP 1276426A4
Authority
EP
European Patent Office
Prior art keywords
systems
fluids
transport
methods
production techniques
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01918390A
Other languages
German (de)
French (fr)
Other versions
EP1276426A2 (en
Inventor
Yehoshua Yeshurun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanopass Ltd
Original Assignee
Nanopass Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13499700A external-priority patent/IL134997A0/en
Priority claimed from US09/589,369 external-priority patent/US6558361B1/en
Application filed by Nanopass Ltd filed Critical Nanopass Ltd
Publication of EP1276426A2 publication Critical patent/EP1276426A2/en
Publication of EP1276426A4 publication Critical patent/EP1276426A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213—Venting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150847—Communication to or from blood sampling device
    • A61B5/150854—Communication to or from blood sampling device long distance, e.g. between patient's home and doctor's office
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
EP01918390A 2000-03-09 2001-03-07 Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems Withdrawn EP1276426A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US589368 1990-09-28
US589369 1990-09-28
IL13499700A IL134997A0 (en) 2000-03-09 2000-03-09 Health care system based on micro device
IL13499700 2000-03-09
US58936800A 2000-06-08 2000-06-08
US09/589,369 US6558361B1 (en) 2000-03-09 2000-06-08 Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
PCT/US2001/007170 WO2001066065A2 (en) 2000-03-09 2001-03-07 Systems and methods for fluid transport through dermal barriers

Publications (2)

Publication Number Publication Date
EP1276426A2 EP1276426A2 (en) 2003-01-22
EP1276426A4 true EP1276426A4 (en) 2008-03-19

Family

ID=27271924

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01918390A Withdrawn EP1276426A4 (en) 2000-03-09 2001-03-07 Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems

Country Status (3)

Country Link
EP (1) EP1276426A4 (en)
AU (1) AU2001245472A1 (en)
WO (1) WO2001066065A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
GB0030929D0 (en) * 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
EP1490147A2 (en) 2002-03-04 2004-12-29 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
ATE490037T1 (en) 2004-08-16 2010-12-15 Functional Microstructures Ltd METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT
WO2007130718A2 (en) * 2006-01-31 2007-11-15 Kralick Francis A Implantable micro-system for treatment of hydrocephalus
US8206334B2 (en) 2006-01-31 2012-06-26 Kralick Francis A Implantable micro-system for treatment of hydrocephalus
JP2009545368A (en) * 2006-08-01 2009-12-24 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Ultrasonic enhanced micro needle
EP1967581B1 (en) * 2007-03-08 2016-08-17 Imec CMOS compatible method for manufacturing microneedle structures
EP2338557A1 (en) 2009-12-23 2011-06-29 Debiotech S.A. Soluble microneedle
EP2343550B1 (en) 2009-12-30 2013-11-06 Imec Improved microneedle
WO2019058329A1 (en) * 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Methods and systems of producing microneedle arrays
US11690739B1 (en) 2020-08-25 2023-07-04 Francis A. Kralick Implantable device for treatment of hydrocephalus
US11717660B2 (en) 2021-07-29 2023-08-08 Nanopass Technologies Ltd. Silicon microneedle structure and production method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
FR2535602A1 (en) * 1982-11-05 1984-05-11 Stallergenes Lab Scarifying device
EP0407063A1 (en) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Tines structure of clinical applicator
WO1996017648A1 (en) * 1994-12-09 1996-06-13 Novartis Ag Transdermal system
DE19525607A1 (en) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
WO2000009184A1 (en) * 1998-08-13 2000-02-24 Imprint Pharmaceuticals Limited Apparatus for delivering a substance having one or more needles driven at high velocity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6077251A (en) * 1997-10-30 2000-06-20 Ting; Windsor Medicinal agent administration system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
FR2535602A1 (en) * 1982-11-05 1984-05-11 Stallergenes Lab Scarifying device
EP0407063A1 (en) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Tines structure of clinical applicator
WO1996017648A1 (en) * 1994-12-09 1996-06-13 Novartis Ag Transdermal system
DE19525607A1 (en) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
WO2000009184A1 (en) * 1998-08-13 2000-02-24 Imprint Pharmaceuticals Limited Apparatus for delivering a substance having one or more needles driven at high velocity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0166065A3 *

Also Published As

Publication number Publication date
WO2001066065A3 (en) 2002-01-31
WO2001066065A2 (en) 2001-09-13
AU2001245472A1 (en) 2001-09-17
EP1276426A2 (en) 2003-01-22

Similar Documents

Publication Publication Date Title
AU2003209645A8 (en) Devices and methods for transporting fluid across a biological barrier
AU2001282866A1 (en) Multi-layer surveying systems and methods with multi-layer incentives
GB0211638D0 (en) Barrier film and method for production thereof
GB0124613D0 (en) System and method for separating fluids
AU2001255714A1 (en) Systems and methods for the collaborative design, construction, and maintenance of fluid processing plants
AU5323201A (en) Systems and methods for recognizing preferred wagerers
HUP0302730A3 (en) Polyethylene pipe resins and production thereof
AU2002241567A1 (en) Fluid delivery and measurement systems and methods
AU8466501A (en) Multi-component biological transport systems
AU2001282995A1 (en) Transport logistics systems and methods
EP1276426A4 (en) Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
EP1480906A4 (en) Liquids dispensing systems and methods
IL162202A0 (en) Detection systems and methods
AU3866101A (en) System and method for transferring cryogenic fluids
TW511713U (en) The earthquake alarm
GB2376073B (en) Fluid-gauging systems and methods
GB0112103D0 (en) Fluid transportation system
GB0124615D0 (en) A method and system for handling production fluid
HK1043821A1 (en) Sumptuary and timesaving semi-shield method for contructing a pipeline in the ground.
SG88820A1 (en) Column packing and method for manufacturing the same
GB0013584D0 (en) Automated flow patch-clamp system
EP1374888A4 (en) Remedies for arthritis deformans and remedies for rheumatoid arthritis
AU2001283468A1 (en) Systems and methods for gas exchange and/or organic separation from fluids
GB0101118D0 (en) Fluid transport system
GB2373051B (en) Fluid storage systems

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020920

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

A4 Supplementary search report drawn up and despatched

Effective date: 20080218

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 5/00 20060101ALI20080212BHEP

Ipc: A61M 37/00 20060101AFI20080212BHEP

17Q First examination report despatched

Effective date: 20081223

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20091001