EP1228071A4 - Pharmaceutically active isoindoline derivatives - Google Patents
Pharmaceutically active isoindoline derivativesInfo
- Publication number
- EP1228071A4 EP1228071A4 EP00977095A EP00977095A EP1228071A4 EP 1228071 A4 EP1228071 A4 EP 1228071A4 EP 00977095 A EP00977095 A EP 00977095A EP 00977095 A EP00977095 A EP 00977095A EP 1228071 A4 EP1228071 A4 EP 1228071A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmaceutically active
- isoindoline derivatives
- active isoindoline
- derivatives
- oxoisoindoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10176420A EP2263669B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP06009632A EP1698334B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP10176390A EP2255801B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
SI200030951T SI1228071T1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
ES06009632T ES2363933T3 (en) | 1999-11-12 | 2000-11-09 | PHARMACEUTICALLY ACTIVE ISOINDOLINE DERIVATIVES. |
CY20071100487T CY1107610T1 (en) | 1999-11-12 | 2007-04-05 | MEDICINAL ACTIVE ISINOLIN PRODUCTS |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US590344 | 1996-01-19 | ||
US16516899P | 1999-11-12 | 1999-11-12 | |
US165168P | 1999-11-12 | ||
US59034400A | 2000-06-08 | 2000-06-08 | |
US09/708,199 US6667316B1 (en) | 1999-11-12 | 2000-11-08 | Pharmaceutically active isoindoline derivatives |
US708199 | 2000-11-08 | ||
PCT/US2000/030770 WO2001034606A1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06009632A Division EP1698334B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP06009632.8 Division-Into | 2006-05-10 | ||
EP10176390.2 Division-Into | 2010-09-13 | ||
EP10176420.7 Division-Into | 2010-09-13 |
Publications (4)
Publication Number | Publication Date |
---|---|
EP1228071A1 EP1228071A1 (en) | 2002-08-07 |
EP1228071A4 true EP1228071A4 (en) | 2002-12-04 |
EP1228071B1 EP1228071B1 (en) | 2007-03-28 |
EP1228071B8 EP1228071B8 (en) | 2012-02-29 |
Family
ID=27389110
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06009632A Expired - Lifetime EP1698334B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP10176420A Expired - Lifetime EP2263669B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP10176390A Expired - Lifetime EP2255801B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP00977095A Expired - Lifetime EP1228071B8 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06009632A Expired - Lifetime EP1698334B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP10176420A Expired - Lifetime EP2263669B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
EP10176390A Expired - Lifetime EP2255801B1 (en) | 1999-11-12 | 2000-11-09 | Pharmaceutically active isoindoline derivatives |
Country Status (19)
Country | Link |
---|---|
US (1) | US6667316B1 (en) |
EP (4) | EP1698334B1 (en) |
JP (1) | JP5116201B2 (en) |
CN (1) | CN1325497C (en) |
AT (4) | ATE544452T1 (en) |
AU (2) | AU782409B2 (en) |
CA (1) | CA2392081C (en) |
CY (2) | CY1107610T1 (en) |
DE (1) | DE60034139T2 (en) |
DK (2) | DK2263669T3 (en) |
ES (4) | ES2282147T3 (en) |
FI (1) | FI119931B (en) |
HK (2) | HK1049158A1 (en) |
MX (1) | MXPA02004793A (en) |
NO (2) | NO323633B1 (en) |
NZ (1) | NZ519459A (en) |
PT (2) | PT2263669E (en) |
SI (1) | SI1228071T1 (en) |
WO (1) | WO2001034606A1 (en) |
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US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US6518281B2 (en) * | 1995-08-29 | 2003-02-11 | Celgene Corporation | Immunotherapeutic agents |
EP0918746B1 (en) * | 1996-08-12 | 2003-04-09 | Celgene Corporation | Immunotherapeutic agents and their use in the reduction of cytokine levels |
US8030343B2 (en) * | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
US7491634B2 (en) * | 2006-04-28 | 2009-02-17 | Asm International N.V. | Methods for forming roughened surfaces and applications thereof |
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DE60231989D1 (en) * | 2001-08-06 | 2009-05-28 | Childrens Medical Center | ANTIANGIOGENIC EFFECT OF NITROGEN SUBSTITUTED THALIDOMIDE ANALOGUE |
US6962940B2 (en) * | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
CA2486141A1 (en) * | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
ZA200503024B (en) | 2002-10-15 | 2006-11-29 | Celgene Corp | Selective cytokine inhibitory drugs for treating myelodysplastic syndrome |
US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
US20050203142A1 (en) * | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
US7776907B2 (en) * | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
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US4173652A (en) | 1976-12-18 | 1979-11-06 | Akzona Incorporated | Pharmaceutical hydroxamic acid compositions and uses thereof |
SE434638B (en) | 1980-06-06 | 1984-08-06 | Lekemedelsfabriken Medica Ab | NEW THERAPEUTIC WORLDFUL TAURIN DERIVATIVES AND THEIR PREPARATION |
US4820828A (en) | 1987-03-04 | 1989-04-11 | Ortho Pharmaceutical Corporation | Cinnamohydroxamic acids |
US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
US5605914A (en) | 1993-07-02 | 1997-02-25 | Celgene Corporation | Imides |
US5801195A (en) | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
ES2151156T3 (en) | 1995-07-26 | 2000-12-16 | Pfizer | ACID DERIVATIVES N- (AROIL) GLYCINE HYDROXAMICS AND RELATED COMPOUNDS. |
US5658940A (en) | 1995-10-06 | 1997-08-19 | Celgene Corporation | Succinimide and maleimide cytokine inhibitors |
ATE262899T1 (en) | 1996-01-02 | 2004-04-15 | Aventis Pharma Inc | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIZAEUR COMPOUNDS |
CZ297278B6 (en) * | 1996-08-07 | 2006-10-11 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives and their use |
EP0918746B1 (en) | 1996-08-12 | 2003-04-09 | Celgene Corporation | Immunotherapeutic agents and their use in the reduction of cytokine levels |
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WO1997008143A1 (en) * | 1995-08-29 | 1997-03-06 | Celgene Corporation | Inhibitors of tumor necrosis factor alpha |
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WO1998024763A2 (en) * | 1996-12-03 | 1998-06-11 | Celgene Corporation | Immunotherapeutic imides/amides as pde iv and tnf inhibitors |
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