EP0933133B1 - Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlussstelle - Google Patents
Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlussstelle Download PDFInfo
- Publication number
- EP0933133B1 EP0933133B1 EP99101930A EP99101930A EP0933133B1 EP 0933133 B1 EP0933133 B1 EP 0933133B1 EP 99101930 A EP99101930 A EP 99101930A EP 99101930 A EP99101930 A EP 99101930A EP 0933133 B1 EP0933133 B1 EP 0933133B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- sliding
- bush
- centrifuge
- bearing
- sliding bush
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts
Definitions
- the invention relates to a centrifuge, in particular a sliding seal-free one Flow centrifuge for centrifuging biological fluids and a line for supplying and / or discharging at least one fluid from the Separation unit of such a centrifuge to a stationary Junction.
- Centrifuges are known in which the biological fluid flows through is centrifuged. The fluid is rotating over a line Centrifuge chamber supplied or removed from the chamber. Because of the Relative movement of the centrifuge chamber and the fixed connection point of the Management, however, turns out to be problematic. To a Avoid twisting the wire, find with conventional Flow centrifuges at the connection points rotating seals Use. Such flow centrifuges allow a high one Speed, but it is disadvantageous that the rotary couplings cause abrasion, Leaks and thus injuries and contamination from in the Components containing fluid can lead.
- a flow seal free flow seal centrifuge is known from DE-A-32 42 541 known.
- the line is run by a stationary connection point in a loop around the centrifuge chamber led around.
- the line is connected to a rotating frame that rotates at half the speed of the centrifuge chamber.
- Such Flow centrifuge is also known for example from DE-A-42 20 232.
- the line In the case of the flow-through centrifuges without mechanical seals, the line is relatively large exposed to mechanical stresses with increasing speed solid rising.
- the line forms under the influence of centrifugal forces an outward sweeping loop, which at the fixed junction and the connection to the separation unit high alternating bending loads occur.
- the steep entry and exit angle at the connection points leads for additional friction between the connection adapters and the Line, which in turn leads to increased abrasion.
- the Alternating bending loads and abrasion are the factors that Lifetime of the line or the maximum speed of the centrifuge restrict.
- Flow seal-free flow centrifuges are known, for which Support the pipe bearing.
- WO95 / 17261 describes a flow centrifuge, the centrifuge tube with a Roller bearing is supported.
- the roller bearing which consists of an inner and outer Bearing shell with the rolling elements is part of the line.
- the roller bearing offers the advantage of low bearing friction, which is disadvantageous however, the complex production and thus the relatively high price. This is particularly disadvantageous in that the centrifuge line is a disposable item, which is discarded after use.
- EP-A-0 112 990 describes a flow centrifuge, the Centrifuge tube between the fixed connection point and the connection the separation unit is supported with two plain bearings.
- the plain bearings each have an inner and an outer bearing shell with a cylindrical Tread, which are part of the centrifuge tube, which is why the Hose is relatively expensive to manufacture.
- the sliding surface is large which creates high abrasion and heat. Furthermore shows the Bearing arrangement does not have sufficient axial support to prevent it from sliding out prevents the socket from the sleeve.
- WO 93/12887 describes a centrifuge with two on its centrifuge line Slide bushings are seated.
- the sliding bushes rotate in the bearing shells of the frame.
- Slide bushes and bearing shells each have two inclined to each other Sliding surfaces, the sliding bush snapping into the bearing shell is inserted.
- With the V-shaped sliding surfaces the sliding bushes are on the Bearing cups secured in the axial and radial directions.
- the disadvantage is that the snap-in fixing of the sliding bush in the bearing shell with a relatively large bearing friction when rotating the bushing in the Bearing shell is connected.
- the invention has for its object to provide a centrifuge whose Line for supplying and / or discharging at least one fluid is exposed to relatively low mechanical stress and can still be manufactured simply and inexpensively as a disposable item. This object is achieved with those specified in claim 1 Features.
- Another object of the invention is to provide a conduit for feeding and / or removing at least one fluid from or to the separation unit to provide a centrifuge that is simple and inexpensive to use Manufacturing and operating the centrifuge at high speeds Relatively low mechanical stresses on the line allowed. This object is achieved with those specified in claim 8 Features.
- the bearing shell preferably opened to allow easy insertion of the socket guarantee.
- the bearing arrangement advantageously has one Snap on, with a longitudinal, slot-shaped opening of the Bearing shell is slightly narrower than the diameter of the bush. But other conventional insertion mechanisms are also conceivable and of the invention includes.
- the sliding bush can be used as a separate component, preferably as Injection molded part, be formed, which is pushed onto the line and with the Cable is connected in a rotationally fixed manner, for example welded or glued.
- the sliding bush can also be made in one piece with the line.
- the sliding bush and the bearing shell each have a cylindrical section on, which connects to their sliding surface.
- the cylindrical sections of Slide bushes and bearing shells do not represent a running surface, they only serve the additional centering or adjustment of the line. Through the The internal stress of the line becomes the sliding surface of the sliding bush on the sliding surface pressed the bearing shell, the cylindrical sections of the sliding bush and Bearing shell are not loaded.
- the sliding surfaces are advantageously of this type designed that only a very small circular contact surface is created.
- a line for supplying and / or discharging at least one fluid in this context is not just a hose with one or more Lumens, but also an arrangement of several single-lumen tubes Roger that.
- the sliding bushing consists of a material which has a lower hardness than the material from which the bearing shell is made. This has the advantage that the fatigue strength of the non-replaceable bearing shell is ensured. In contrast, the wear of the sliding bush is not disadvantageous as this is part of the line intended for single use is.
- the sliding bush is preferably made of plastic, preferably polyacetal plastic (POM) or Teflon, i.e. a material with a lower Abrasion resistance, while the bearing shell is preferably made of metal, in particular Steel, i.e. a material with a higher abrasion resistance.
- Advantageous are especially materials with a low coefficient of friction.
- the sliding surface of the bearing shell and the sliding bush are preferably machined in such a way that the lowest possible friction losses occur.
- the bearing shell is advantageously slotted at one point.
- the cylindrical portion of the sliding bush is inserted, and the sliding surface of the sliding bush is then on the sliding surface of the bearing shell hung up.
- the sliding bush is thus centered in the bearing shell.
- the slide bearing for supporting the line is purpose-wise on the side rotating rotating frame of the centrifuge arranged the separation unit carries, so that the line laterally in an arc around the Separation unit can be guided to the fixed connection point. If the plain bearing is approximately at the level at which the separation unit is arranged, i.e. in the area of the lower third of that of the Separation unit to the fixed line running line is the line is adequately supported. More plain bearings are then available Support of the line is no longer required.
- Fig. 1 shows a schematic diagram of a flow centrifuge free of mechanical seals for centrifuging a biological fluid, in particular blood, which corresponds in structure and function to the centrifuge described in DE 32 42 541 A1.
- the flow centrifuge has a rotating frame 1 with a lower 1a and an upper support plate 1b and two side parts 1c, 1d.
- the rotating frame 1 is rotatably mounted on a stationary frame 2 about a vertical axis 3 and is driven by a drive unit (not shown in FIG. 1) at a speed n 1 .
- a separation unit 4 in the form of a cylindrical chamber is rotatably mounted about the axis of rotation of the frame.
- the separation unit can be attached to the top or bottom of the support plate.
- a flexible Line 6 in which one or more hoses for feeding and discharging the blood or the blood components in the centrifuge chamber 4 or from the Chamber are summarized around the centrifuge chamber 4 and connected to the bottom of the chamber. A twisting of the line is avoided in that the line 6 at half the speed as the Centrifuge chamber is guided around this.
- Line 6 is part of a disposable, which in addition to Centrifuge chamber 4 still bags for collecting the by centrifugation separated blood components can include.
- the disposable is in the Centrifuge inserted and discarded after use.
- Such Hose arrangements are part of the prior art, so that here no further explanation is necessary.
- a comprehensive collection bag Disposable is for example in DE-A-28 45 364 and DE-A-28 45 399 described.
- the bearing has a sliding bush sitting on the hose line and one Bearing shell, which is attached to the rotating frame 1.
- Fig. 2 shows the section that one or more hoses 6a, 6b comprehensive hose line 6, on which the sliding bush 9 sits.
- From Polyacetal plastic (POM) or Teflon existing sliding bush 9 has one cylindrical section 10, which in a forming the sliding surface conical section 11 merges. At its the conical section opposite end is the cylindrical portion 10 of the slide bush 9 provided with a circumferential approach 12.
- the sliding bush 9 is fixed to the Hose line 6 glued or welded, which is characterized by its axial Hole extends.
- the bearing shell 13 has a stepped bore with a cylindrical Section 14 and a conical section 15 which is the same Has conicity as the conical section 11 of the sliding bush 9. At a The bearing shell 13 is slotted. The width of the opening 16 is so dimensioned that the cylindrical portion 10 of the sliding bush 9 laterally in the Bearing shell 13 can be pressed and snapped into the bearing shell is set. The length of the cylindrical portion 10 of the slide bush 9 is slightly larger than the height of the bearing shell 13.
- FIG. 5 shows the sliding bush 9 of the line 6 inserted in the bearing shell 13.
- the cylindrical portion 10 is in the lateral opening 16 of the bearing shell 13 inserted, and the conical Section 11 of the sliding bush is on the conical sliding surface 15 of the Bearing shell.
- the bearing shell is in this way on the rotating frame attached that the sliding surface 15 is above.
- the sliding bush 9 is in the Bearing shell 13 fixed in the axial and radial directions, the circumferential Approach 12 of the sliding bush slipping out of the bearing shell prevented.
- FIG. 6 shows the sliding bush 9 'inserted into the bearing shell 13 another embodiment.
- the sliding surfaces the bearing shell and the sliding bush formed such that there is sliding bush and touch the bearing shell only along a circular line 17. So that's it Minimal contact area.
Landscapes
- Centrifugal Separators (AREA)
Description
- Fig. 1
- eine Prinzipskizze eines Ausführungsbeispiels einer gleitdichtungsfreien Durchflußzentrifuge zum Zentrifugieren von einem biologischen Fluid, insbesondere Blut,
- Fig. 2
- eine vergrößerte Darstellung eines Leitungsabschnitts der in die Zentrifuge einzulegenden Schlauchleitung mit einer Gleitbuchse,
- Fig. 3
- die Lagerschale zum Einlegen der Gleitbuchse der Schlauchleitung in vergrößerter Darstellung,
- Fig. 4
- die Lagerschale von Fig. 3 in der Ansicht aus der Richtung des Pfeils IV,
- Fig. 5
- die in die Lagerschale eingesetzte Gleitbuchse der Schlauchleitung und
- Fig. 6
- die Gleitflächen der Lagerschale und der Gleitbuchse, wobei die Auflagefläche kreislinienförmig ist.
Claims (11)
- Zentrifuge mit einem Drehrahmen (1), der an einem Gestell (2) drehbar gelagert ist, einer an dem Gestell (2) drehbar gelagerten Separationseinheit (4), die mit doppelter Drehzahl in gleichem Drehsinn wie der Drehrahmen antreibbar ist, einer Leitung (6) zum Zuführen und/oder Abführen mindestens eines Fluids, die von einer ortsfesten Anschlußstelle (5) um die Separationseinheit (4) herumgeführt und an einer der ortsfesten Anschlußstelle (5) abgewandten Seite der Separationseinheit (4) an dieselbe angeschlossen ist und mindestens einem Lager (7) zur Abstützung der Leitung (6), das eine auf der Leitung sitzende Gleitbuchse (9) und eine Lagerschale (13) aufweist, wobei die Lagerschale (13) an dem Drehrahmen (1) befestigt ist und die Lagerschale (13) und die Gleitbuchse (9) jeweils eine sich im Radius aufweitende Gleitfläche (11,15) aufweisen, so daß die Gleitbuchse (9) in der Lagerschale (13) in Richtung der Längsachse der Gleitbuchse (9) und quer zu deren Längsachse abgestützt ist, dadurch gekennzeichnet, daß die Gleitbuchse (9) einen zylindrischen Abschnitt (10) aufweist, an den sich deren im Radius aufweitende Gleitfläche (11) anschließt, und die Lagerschale (13) einen zylindrischen Abschnitt (14) aufweist, an den sich deren im Radius aufweitende Gleitfläche (15) anschließt.
- Zentrifuge nach Anspruch 1, dadurch gekennzeichnet, daß die Gleitbuchse (9) aus einem Material besteht, das eine geringere Härte als das Material hat, aus dem die Lagerschale (13) besteht.
- Zentrifuge nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die Gleitbuchse (9) aus Kunststoff, vorzugsweise Polyacetal-Kunststoffoder Teflon besteht.
- Zentrifuge nach einem der Ansprüche 1-3, dadurch gekennzeichnet, daß die Lagerschale (13) aus Metall, vorzugsweise Stahl, besteht.
- Zentrifuge nach einem der Ansprüche 1-4, dadurch gekennzeichnet, daß die sich im Radius aufiveitenden Gleitflächen (11,15) von Gleitbuchse (9) und Lagerschale (13) kegelförmig sind.
- Zentrifuge nach einem der Ansprüche 1-5, dadurch gekennzeichnet, daß die Lagerschale (13) zum Einlegen der Gleitbuchse (9) an einer Seite geschlitzt ist.
- Zentrifuge nach einem der Ansprüche 1-6, dadurch gekennzeichnet, daß der zylindrische Abschnitt (10) der Gleitbuchse (9) mit einem umlaufenden Ansatz (12) versehen ist.
- Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von einer Separationseinheit, die an einem Drehrahmen drehbar gelagert ist, der an einem Gestell drehbar gelagert ist, wobei die Separationseinheit mit doppelter Drehzahl in gleichem Drehsinn wie der Drehrahmen angetrieben ist, wobei auf der Leitung mindestens eine Gleitbuchse (9) sitzt, die eine sich im Radius erweiternde Gleitfläche (11) aufweist, so daß die Gleitbuchse (9) in eine Lagerschale einsetzbar und in Richtung der Längsachse der Gleitbuchse (9) und quer zu deren Längsachse in der Lagerschale abgestützt ist, dadurch gekennzeichnet, daß die Gleitbuchse (9) einen zylindrischen Abschnitt (10) aufweist, an den sich die im Radius aufweitende Gleitfläche (11) anschließt.
- Leitung nach Anspruch 8, dadurch gekennzeichnet, daß die Gleitbuchse (9) aus Kunststoff, vorzugsweise Polyacetal-Kunststoff oder Teflon, besteht.
- Leitung nach Anspruch 8 oder 9, dadurch gekennzeichnet, daß die sich im Radius aufweitende Gleitfläche (11) der Gleitbuchse (9) kegelförmig ist.
- Leitung nach Anspruch 10, dadurch gekennzeichnet, daß der zylindrische Abschnitt (10) der Gleitbuchse (9) mit einem umlaufenden Ansatz (12) versehen ist.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803534A DE19803534C2 (de) | 1998-01-30 | 1998-01-30 | Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle |
DE19803534 | 1998-01-30 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0933133A2 EP0933133A2 (de) | 1999-08-04 |
EP0933133A3 EP0933133A3 (de) | 2000-06-21 |
EP0933133B1 true EP0933133B1 (de) | 2002-05-08 |
Family
ID=7856094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99101930A Expired - Lifetime EP0933133B1 (de) | 1998-01-30 | 1999-01-29 | Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlussstelle |
Country Status (5)
Country | Link |
---|---|
US (1) | US6273849B1 (de) |
EP (1) | EP0933133B1 (de) |
JP (1) | JP4354563B2 (de) |
DE (2) | DE19803534C2 (de) |
ES (1) | ES2177149T3 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102022114273A1 (de) | 2022-06-07 | 2023-12-07 | Fresenius Medical Care Deutschland Gmbh | Beschichtung von Hohlfasermembranen in der Medizintechnik |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1043071A1 (de) * | 1999-04-09 | 2000-10-11 | Jean-Denis Rochat | Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung |
US7008366B1 (en) * | 2000-10-27 | 2006-03-07 | Zymequest, Inc. | Circumferentially driven continuous flow centrifuge |
JP5147154B2 (ja) * | 1999-10-28 | 2013-02-20 | ベリコ メディカル,インコーポレイテッド | 円周状に駆動される連続流遠心分離 |
WO2002062482A2 (en) | 2000-11-02 | 2002-08-15 | Gambro, Inc. | Fluid separation devices, systems and methods |
DE10129769A1 (de) * | 2001-06-20 | 2003-01-09 | Fresenius Hemocare Gmbh | Schlauchanordnung und Verfahren zu ihrer Herstellung |
DE10142744C1 (de) * | 2001-08-31 | 2003-05-22 | Fresenius Hemocare Gmbh | Zentrifuge |
US7479123B2 (en) | 2002-03-04 | 2009-01-20 | Therakos, Inc. | Method for collecting a desired blood component and performing a photopheresis treatment |
US7211037B2 (en) | 2002-03-04 | 2007-05-01 | Therakos, Inc. | Apparatus for the continuous separation of biological fluids into components and method of using same |
EP1981963A1 (de) | 2004-12-27 | 2008-10-22 | Fresenius Medical Care Deutschland GmbH | Reaktor und reaktoreinheit mit hohlfasern |
WO2008002004A1 (en) * | 2006-06-30 | 2008-01-03 | Medikan Inc. | Centrifuge and centrifuging method |
KR100772970B1 (ko) | 2006-06-30 | 2007-11-02 | 메디칸(주) | 원심분리기 및 원심분리방법 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US4113173A (en) * | 1975-03-27 | 1978-09-12 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus |
US4120448A (en) * | 1977-06-08 | 1978-10-17 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus with automatically positioned collection port |
US4114802A (en) | 1977-08-29 | 1978-09-19 | Baxter Travenol Laboratories, Inc. | Centrifugal apparatus with biaxial connector |
US4164318A (en) * | 1977-10-12 | 1979-08-14 | Baxter Travenol Laboratories, Inc. | Centrifugal processing apparatus with reduced-load tubing |
US4146172A (en) * | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
US4185629A (en) * | 1977-10-18 | 1980-01-29 | Baxter Travenol Laboratories, Inc. | Method and apparatus for processing blood |
US4109852A (en) * | 1977-10-21 | 1978-08-29 | Baxter Travenol Laboratories, Inc. | Centrifugal strain relief sheath for processing apparatus |
US4221322A (en) * | 1977-10-31 | 1980-09-09 | Union Carbide Corporation | Tube guide insert and constraint fittings for compensating rotor |
DE3242541A1 (de) * | 1982-11-18 | 1984-05-24 | Fresenius AG, 6380 Bad Homburg | Zentrifuge |
US4439178A (en) | 1982-12-30 | 1984-03-27 | International Business Machines Corporation | Sealless centrifuge processing channel and tube system |
JPS61245855A (ja) * | 1985-04-22 | 1986-11-01 | Green Cross Corp:The | 連続式血液分離装置 |
IT1251147B (it) * | 1991-08-05 | 1995-05-04 | Ivo Panzani | Tubo multilume per separatore centrifugo particolarmente per sangue |
WO1993012887A1 (en) | 1991-12-23 | 1993-07-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
DE4220232A1 (de) * | 1992-06-20 | 1993-12-23 | Fresenius Ag | Zentrifuge |
US5514069A (en) * | 1993-12-22 | 1996-05-07 | Baxter International Inc. | Stress-bearing umbilicus for a compact centrifuge |
US5704887A (en) * | 1995-06-07 | 1998-01-06 | Baxter International Inc. | Easy load umbilicus holder for a centrifuge |
US5989177A (en) * | 1997-04-11 | 1999-11-23 | Baxter International Inc. | Umbilicus gimbal with bearing retainer |
-
1998
- 1998-01-30 DE DE19803534A patent/DE19803534C2/de not_active Expired - Fee Related
-
1999
- 1999-01-19 US US09/233,314 patent/US6273849B1/en not_active Expired - Lifetime
- 1999-01-29 EP EP99101930A patent/EP0933133B1/de not_active Expired - Lifetime
- 1999-01-29 JP JP02156099A patent/JP4354563B2/ja not_active Expired - Fee Related
- 1999-01-29 ES ES99101930T patent/ES2177149T3/es not_active Expired - Lifetime
- 1999-01-29 DE DE59901371T patent/DE59901371D1/de not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102022114273A1 (de) | 2022-06-07 | 2023-12-07 | Fresenius Medical Care Deutschland Gmbh | Beschichtung von Hohlfasermembranen in der Medizintechnik |
WO2023237523A1 (de) | 2022-06-07 | 2023-12-14 | Fresenius Medical Care Deutschland Gmbh | Beschichtung von hohlfasermembranen in der medizintechnik |
Also Published As
Publication number | Publication date |
---|---|
DE59901371D1 (de) | 2002-06-13 |
DE19803534C2 (de) | 1999-11-11 |
EP0933133A3 (de) | 2000-06-21 |
JPH11262684A (ja) | 1999-09-28 |
EP0933133A2 (de) | 1999-08-04 |
DE19803534A1 (de) | 1999-08-12 |
ES2177149T3 (es) | 2002-12-01 |
JP4354563B2 (ja) | 2009-10-28 |
US6273849B1 (en) | 2001-08-14 |
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