EP0546125A1 - Facteur osteogene - Google Patents

Facteur osteogene

Info

Publication number
EP0546125A1
EP0546125A1 EP19920903107 EP92903107A EP0546125A1 EP 0546125 A1 EP0546125 A1 EP 0546125A1 EP 19920903107 EP19920903107 EP 19920903107 EP 92903107 A EP92903107 A EP 92903107A EP 0546125 A1 EP0546125 A1 EP 0546125A1
Authority
EP
European Patent Office
Prior art keywords
nucleotide sequence
seq
subunit
encodes
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920903107
Other languages
German (de)
English (en)
Other versions
EP0546125A4 (en
Inventor
Lynn Grinna
Georgia Theofan
Thomas F. Parsons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Corp
Original Assignee
Xoma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Corp filed Critical Xoma Corp
Publication of EP0546125A1 publication Critical patent/EP0546125A1/fr
Publication of EP0546125A4 publication Critical patent/EP0546125A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Préparations protéiques à action ostéogène, qui comprennent un hétérodimère de la sous-unité B P3 OF 31-34 et de la sous-unité D P3 OF 31-34, lesdites sous-unité étant liées à l'aide d'au moins une liaison bisulfure et procédés de production desdites préparations. La présente invention concerne également des lignées cellulaires transformées à l'aide de séquences de nucléotides codant la sous-unité B P3 OF 31-34 et la sous-unité D P3 OF 31-34 et des vecteurs comprenant ces séquences associées fonctionnellement avec une séquence de régulation d'expression.
EP9292903107A 1991-06-20 1991-07-01 Osteogenic factor Withdrawn EP0546125A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/718,274 US5284756A (en) 1988-10-11 1991-06-20 Heterodimeric osteogenic factor
US718274 1991-06-20

Publications (2)

Publication Number Publication Date
EP0546125A1 true EP0546125A1 (fr) 1993-06-16
EP0546125A4 EP0546125A4 (en) 1994-10-05

Family

ID=24885482

Family Applications (1)

Application Number Title Priority Date Filing Date
EP9292903107A Withdrawn EP0546125A4 (en) 1991-06-20 1991-07-01 Osteogenic factor

Country Status (6)

Country Link
US (3) US5284756A (fr)
EP (1) EP0546125A4 (fr)
JP (1) JPH07505039A (fr)
AU (1) AU654316B2 (fr)
CA (1) CA2093790A1 (fr)
WO (1) WO1993000049A1 (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
EP1225225A3 (fr) * 1988-04-08 2003-01-08 Stryker Corporation Dispositifs ostéogéniques
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3504263B2 (ja) * 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
US5610021A (en) * 1992-02-21 1997-03-11 Creative Biomolecules, Inc. Compositions and methods for identification and use of soluble complex forms of osteogenic proteins
EP0687272B1 (fr) * 1993-03-04 2007-01-17 Stryker Corporation Procedes et compositions pour la production de proteines osteogenes recombinantes
JPH09503903A (ja) * 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−６
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
AU6787594A (en) * 1994-03-10 1995-09-25 Human Genome Sciences, Inc. Bone morphogenic protein-10
EP0691349A3 (fr) * 1994-07-04 1997-09-10 Hoechst Japan Proteines dimériques morphogénétiques d'origine osseuse et leur fragments et anologues et compositions pharmaceutiques les contenants
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
ATE364629T1 (de) * 1996-01-22 2007-07-15 Curis Inc Methoden zur herstellung von op-1 morphogen analoge
US20030185792A1 (en) * 1996-01-22 2003-10-02 Curis, Inc. Morphogen analogs of bone morphogenic proteins
US5851802A (en) * 1996-03-22 1998-12-22 Xoma Corporation Methods for recombinant microbial production of fusion proteins and BPI-derived peptides
US5863731A (en) * 1996-11-01 1999-01-26 The Penn State Research Foundation Polymerase chain reaction-based diagnostic test for the detection of Xanthomonas campestris pathovar pelargonii
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
CA2291514C (fr) 1997-05-30 2011-07-12 Creative Biomolecules, Inc. Procedes pour evaluer la morphogenese des tissus et leur activite
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
EP1007673B1 (fr) 1997-07-30 2008-12-17 Emory University Nouvelle proteine de mineralisation osseuse, adn, vecteurs et systemes d'expressions
US6958149B2 (en) * 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
CA2346375C (fr) 1998-10-06 2013-04-23 Rush-Presbyterian-St. Luke's Medical Center Procede de traitement par chimionucleolyse
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
EP1223990B1 (fr) 1999-10-15 2004-07-28 Genetics Institute, LLC Formulations a base d'acide hyaluronique aux fins de l'administration de proteines osteogenes
EP2140881B1 (fr) 1999-12-16 2013-04-17 Biogen Idec MA Inc. Procédés de traitement de maladie hémorragique ou ischémique du système nerveux central, utilisant des antagonistes d'intégrine anti alpha 4
US20030104977A1 (en) * 2000-03-31 2003-06-05 Ugo Ripamonti Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
ATE393573T1 (de) * 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US6822033B2 (en) 2001-11-19 2004-11-23 United States Gypsum Company Compositions and methods for treating set gypsum
KR100450864B1 (ko) * 2001-11-23 2004-10-01 한국과학기술연구원 Ｒｎａ 표적 분자에 대해 특이성이 향상된네오마이신-클로람페니콜 헤테로 이합체 및 그의 제조방법
MXPA04011337A (es) * 2002-05-17 2005-07-01 Wyeth Corp Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas.
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
CN1878565B (zh) * 2003-09-12 2011-01-12 惠氏公司 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂
US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
WO2006081379A1 (fr) * 2005-01-26 2006-08-03 Wyeth Utilisation de sfrps, en tant que marqueurs d'une activte bmp
KR100775958B1 (ko) * 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
EP1863518A2 (fr) * 2005-03-30 2007-12-12 Wyeth Methodes pour stimuler la pousse des cheveux par administration de proteines bmp
US20070105762A1 (en) * 2005-03-30 2007-05-10 Jung Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
US7910552B2 (en) 2005-05-27 2011-03-22 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US8070895B2 (en) 2007-02-12 2011-12-06 United States Gypsum Company Water resistant cementitious article and method for preparing same
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
JP2011514331A (ja) 2008-02-13 2011-05-06 キース フルスカ， 血管硬化症の治療における使用のためのｂｍｐ−７
CA2720845A1 (fr) * 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Formulations liquides tamponnees de gdf-5
US8329308B2 (en) 2009-03-31 2012-12-11 United States Gypsum Company Cementitious article and method for preparing the same
SG10201913070UA (en) * 2015-08-25 2020-03-30 Histide Ag Compounds for inducing tissue formation and uses thereof
CN105218659B (zh) * 2015-11-03 2016-06-01 筴文奎 人骨形成蛋白2成熟肽及其表达

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003733A1 (fr) * 1988-10-11 1990-04-19 International Genetic Engineering, Inc. Facteurs osteogeniques

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458397A (en) * 1966-12-08 1969-07-29 Squibb & Sons Inc Process for producing osteogenic material
US4488911A (en) * 1975-10-22 1984-12-18 Luck Edward E Non-antigenic collagen and articles of manufacture
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4761471A (en) * 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
DE3037513C2 (de) * 1980-10-03 1983-05-05 Steffan, Wolfgang, 8425 Neustadt Kollagene Wundauflage
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4863899A (en) * 1983-05-09 1989-09-05 Todaro George J Biologically active polypeptides
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4804744A (en) * 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
DE3414924A1 (de) * 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert Beschichtetes verankerungsteil fuer implantate
DE3588058T3 (de) * 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US5001169A (en) * 1984-10-24 1991-03-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4734363A (en) * 1984-11-27 1988-03-29 Molecular Diagnostics, Inc. Large scale production of DNA probes
DE3445738A1 (de) * 1984-12-14 1986-06-19 Draenert Klaus Implantat zur knochenverstaerkung und verankerung von knochenschrauben, implantaten oder implantatteilen
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
DE3521684A1 (de) * 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg Verfahren zur beschichtung von polymeren
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
PT87133B (pt) * 1987-04-02 1992-07-31 Amrad Corp Ltd Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif
US4952404A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Promotion of healing of meniscal tissue
JPS6451085A (en) * 1987-08-20 1989-02-27 Sanwa Kagaku Kenkyusho Co Cloned dna of antibacterial polypeptide precursor, its fragment, their preparation and plasmid integrated with said cloned dna or fragment
WO1989010409A1 (fr) * 1988-04-08 1989-11-02 Genetics Institute, Inc. Compositions provoquant la formation d'os et de cartilage
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
EP1225225A3 (fr) * 1988-04-08 2003-01-08 Stryker Corporation Dispositifs ostéogéniques
IL90683A0 (en) * 1988-06-27 1990-01-18 Yissum Res Dev Co Osteogenic growth factors derived from regenerating bone marrow
ATE162223T1 (de) * 1989-03-28 1998-01-15 Genetics Inst Osteoinduktive zusammensetzungen
CA2020729A1 (fr) * 1989-07-19 1991-01-20 Michael C. Kiefer Proteine morphogenetique des os
CA2064878A1 (fr) * 1989-08-21 1991-02-22 Hanne Bentz Proteine specifique des os
DE69027961T2 (de) * 1989-09-06 1997-01-09 Takeda Chemical Industries Ltd Protein, DNA und ihre Verwendung
ES2118723T3 (es) * 1989-10-17 1998-10-01 Stryker Corp Dispositivos osteogenicos.
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
EP0550625B1 (fr) * 1990-09-26 2003-11-05 Genetics Institute, LLC Derives bmp-5
EP0575555B1 (fr) * 1991-03-11 2001-07-18 Curis, Inc. Morphogenese induite par des proteines
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
DK0592562T3 (da) * 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003733A1 (fr) * 1988-10-11 1990-04-19 International Genetic Engineering, Inc. Facteurs osteogeniques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF BIOLOGICAL CHEMISTRY vol. 265, no. 22 , 5 August 1990 , BALTIMORE, MD US pages 13198 - 13205 T. KUBER SAMPATH ET AL. 'Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily' *
See also references of WO9300049A1 *

Also Published As

Publication number Publication date
US5508263A (en) 1996-04-16
US5284756A (en) 1994-02-08
AU654316B2 (en) 1994-11-03
CA2093790A1 (fr) 1992-12-21
AU9162391A (en) 1993-01-25
WO1993000049A1 (fr) 1993-01-07
EP0546125A4 (en) 1994-10-05
JPH07505039A (ja) 1995-06-08
US5411941A (en) 1995-05-02

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