EP0497495A2 - A minimally invasive medical device - Google Patents
A minimally invasive medical device Download PDFInfo
- Publication number
- EP0497495A2 EP0497495A2 EP92300538A EP92300538A EP0497495A2 EP 0497495 A2 EP0497495 A2 EP 0497495A2 EP 92300538 A EP92300538 A EP 92300538A EP 92300538 A EP92300538 A EP 92300538A EP 0497495 A2 EP0497495 A2 EP 0497495A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- wire
- distal end
- passageway
- wire coil
- distal portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22068—Centering
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1047—Balloon catheters with special features or adapted for special applications having centering means, e.g. balloons having an appropriate shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
- A61N2005/1003—Intraluminal radiation therapy having means for centering a radioactive source within the lumen, e.g. balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
- A61N2005/1004—Intraluminal radiation therapy having expandable radiation sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1021—Radioactive fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1025—Wires
Definitions
- This invention relates to minimally invasive medical devices such as wire guides or catheters.
- a coronary stent can be positioned in a treated vessel to maintain the patency of the vessel.
- smooth muscle proliferates or intimal hyperplasia occurs in response to the presence of the stent in the vessel.
- restenosis of the vessel typically occurs within a period of six months.
- Another problem is that abrasion or dissection of the vessel wall may occur during a therapeutic procedure to reopen or enlarge the lumen of the vessel. As a result, thrombi formation and occlusion of the vessel lumen may also occur.
- the device can provide localized radiation treatment in a body passageway such as a coronary vessel in the vascular system. That decreases reproduction of intimal and smooth muscle cells to prevent or curtail intimal hyperplasia and smooth muscle proliferation.
- restenosis of the treated vessel is significantly minimized.
- the distal portion preferably has a distal end that is directable through the tortuous segments of coronary vessels.
- Fig.1 Depicted in Fig.1 is preferred embodiment of an illustrative minimally invasive medical device 10, such as a wire guide, for providing a radiation treatment in part of a body such as a passageway thereof.
- This minimally invasive medical device has particular application as a percutaneously inserted intravascular device for providing a radiation treatment to the area of a coronary vessel having, for example, a stent positioned therein.
- Device 10 comprises flexible elongated member 11 and radiation source 12.
- Flexible elongated member 11 includes proximal portion 13 and distal portion 14. The distal portion is insertable in a body passageway such as a coronary artery of the vascular system and has a distal end 15 that is directable through the vascular system to the treatment site.
- Radiation source 12 comprises commercially available iridium radioactive material attached about or within distal portion 14 as shown.
- Distal portion 14 includes wire coil 16 of commercially available 0.01cms (0.004") diameter stainless steel wire that is wound into a coil having an outside diameter of approximately 0.046cms (0.0183") to 0.048cms (0.019”) and a length of approximately 6 to 9cms.
- Distal portion 14 has a predetermined longitudinal curvature such as approximately 90° longitudinal curvature 17 that extends for about 15mm from distal end 15. As a result, distal end 15 is directable through the body passageway.
- Wire coil 16 includes distal end 18, proximal end 19, and passageway 20 extending longitudinally therebetween.
- Flexible elongated member 11 comprises a stainless steel mandril wire 21 having a uniform diameter of 0.046cms (0.018") about the proximal portion 13. This uniform diameter is within a tolerance of - 0.0038cms (-0.0015") of the wire coil diameter.
- Mandril wire 21 is approximately 40cms in length and has a longitudinally tapered distal end 22 for a length of approximately 15cms. Tapered distal end 22 of the mandril wire is inserted through passageway 20 and attached to distal coil end 18 in a well-known manner by, for example, weld 24.
- Proximal coil end 19 is attached to tapered distal end 22 in a well-known manner using, for example, soft solder 25.
- Flexible elongated member 11, known as a Cope Mandril wire guide is commercially available from Cook Incorporated, Bloomington, Indiana.
- Tapered distal end 22 also includes an annular recess 23 circumferentially positioned thereabout approximately 10mm from directable distal end 15.
- Radiation source 12 comprising a ring of commercially available iridium radioactive material is fixedly positioned in annular recess 23 for providing the radiation treatment.
- FIG.2 depicts an enlarged view of annular recess 23 and radiation source 12 fixedly positioned therein.
- distal portion 66 of a minimally invasive medical device which includes an enhancement to the device of FIG.1.
- Distal portion 66 includes proximal wire coil 68 and distal wire coil 69 having respective longitudinally extending passageways 70 and 71.
- the elongated flexible member of the device includes a mandril wire having tapered distal end 72.
- the tapered distal end of the mandril wire extends longitudinally through the wire coil passageways.
- the distal ends of the mandril wire and distal wire coil 69 are attached together using, for example, weld 76. This forms directable end 67 of distal portion 66 of the minimally invasive medical device.
- the medical device also includes radiation source 73 which is a tubular sleeve of commercially available iridium radioactive material positioned about tapered distal end 72 of a mandril wire and between proximal wire coil 68 and distal wire coil 69.
- Wire coils 68 and 69 are wound from commercially available 0.01cms (0.004") stainless steel wire into coils having an outside diameter of approximately 0.046cms (0.0183”) to 0.048cms (0.019").
- the tubular sleeve has an outside diameter approximating that of the wire coils.
- Proximal wire coil 68 is positioned over the tapered distal end of the mandril wire with the proximal end of the coil being affixed thereto with, for example, soft solder.
- Tubular sleeve radiation source 73 is positioned about the tapered distal end of the mandril wire next to the distal end of proximal wire coil 68.
- the abutting ends of the proximal wire coil and tubular sleeve are affixed to tapered distal end 72 of the mandril wire using, for example, soft solder 74.
- Distal wire coil 69 is positioned about the tapered distal end of the mandril wire abutting the proximal end of the tubular sleeve radiation source.
- the abutting ends of the distal wire coil and tubular sleeve are affixed to tapered distal end 72 of the mandril wire using, for example, soft solder 75.
- minimally invasive medical device 26 which includes an alternative enhancement to the minimally invasive device of FIG.1.
- Medical device 26 includes flexible elongated member 27 and radiation source 28.
- the flexible elongated member includes proximal portion 29 and distal portion 30.
- Distal portion 30 has longitudinal curvature 43 and directable distal end 44.
- mandril wire 31 has distal end 32 that is tapered a shorter distance of, for example, 7cms and extends only partially through wire coil passageway 33 of wire coil 34.
- Wire coil 34 has proximal end 40, distal end 41, and passageway 33 extending longitudinally therebetween.
- the proximal end of the coil is attached to tapered distal end 32 in a well-known manner using, for example, soft solder 42.
- a safety second wire 35 of, for example, 0.0076cms (0.003") by 0.02cms (0.008") rectangular stainless steel having proximal end 36 and distal end 37 is inserted into passageway 33 of wire coil 34.
- the distal ends of the safety wire and wire coil are attached in a well-known manner using, for example, weld 38.
- Proximal end 36 of the safety wire extends through passageway 33 to tapered distal end 32 of mandril wire 31.
- Tapered distal end 32 and proximal safety wire end 36 are attached to wire coil 34 in a well-known manner using, for example, soft solder 39, as shown.
- Radiation source 28 comprising, for example, a sleeve of iridium radioactive material, is fixedly positioned about tapered distal end 32 in wire coil passageway 33 proximal to solder joint 39.
- minimally invasive medical device 45 which is a second alternative enhancement to the device of FIG.1.
- mandril wire 46 having distal end 47 is tapered a distance of, for example, 7cms, and extends only partially into passageway 48 of wire coil 49.
- safety second wire 50 having proximal end 51 and distal end 52 extends approximately the entire length of wire coil passageway 48.
- Distal safety wire end 52 is attached to distal coil end 53 in a well-known manner using, for example, weld 54.
- Proximal safety wire end 51 and tapered distal wire end 47 are attached to proximal wire coil end 55 in a well-known manner using, for example, soft solder 56.
- Radiation source 57 comprising, for example, a sleeve of iridium radioactive material, is fixedly positioned about safety second wire 50 in wire coil passageway 48 a predetermined distance, for example, 5mms from distal wire end 52 to permit controlled radiation of the affected area. This advantageously provides the distal portion with variable flexibility for atraumatic insertion of the device.
- the proximal portion of the cylindrical first wire has a uniform diameter.
- the outer diameter of the distal portion wire coil and the proximal portion of the first wire are within a close tolerance of each other to minimize trauma and abrasion to the vessel wall during insertion to the affected vessel site.
- Minimally invasive medical device 58 such as a catheter, comprises elongated member tube 59 having distal portion 60, proximal portion 61, and passageway 62 extending longitudinally therebetween.
- the device further comprises radiation source 63 attached about the passageway of distal portion 60, and shown embedded in tube 59 about 5mms from end 64 of the tube.
- Radiation source 63 comprises a tubular sleeve of iridium radioactive material.
- Elongated member tube 59 is formed in a well-known manner from any of a number of commercially available plastic materials such as polyethylene, polyurethane, or polytetrafluorethylene.
- the device also includes wire guide 65 which is percutaneously inserted and guided into the vessel. Catheter 59 is then inserted over the wire guide and directed to the treatment site in the vessel.
- Minimally invasive medical device 77 such as a catheter, comprises elongated member tube 78 having distal portion 79, proximal portion 80, and a passageway extending longitudinally therebetween.
- the device further comprises radiation source 84 attached about distal portion 79 in the passageway thereof between proximal wire coil 81 and distal wire coil 85.
- radiation source 84 comprises a tubular sleeve of iridium radioactive material having a passageway extending longitudinally between passageways 82 and 86 of wire coils 81 and 85, respectively.
- the tubular sleeve radiation source is preferably fixedly positioned about the passageway of the elongated member tube between the proximal and distal wire coils 81 and 85 by adhesive to form joints 83 and 87.
- the adhesive extends the entire length of distal wire coil 85 to form a rounded surface at the distal end of the coil and elongated member tube.
- Elongated member tube 78 is formed from plastic materials.
- the flexible elongated member tube has an outer diameter of approximately 0.096cms (0.038”) which is insertable into passageway 89 of commercially available guiding catheter 88.
- the minimally invasive medical device also includes wire guide 90 which is percutaneously inserted and guided into the desired coronary vessel. Flexible elongated member tube 78 is then inserted over the wire guide and directed to the treatment site in the coronary vessel through the passageway of the guiding catheter.
- the above-described minimally invasive intravascular medical device for providing a radiation treatment in a body passageway is merely an illustrative embodiment of the principles of this invention and that alternative devices, instruments, or apparatus may be devised by those skilled in the art.
- many commercially available wire guides and catheters may be modified to attach a radiation source about or in the distal end thereof for providing a radiation treatment to a body passageway and, in particular, preventing intimal hyperplasia and smooth muscle proliferation which causes stenosis or restenosis of the passageway.
- the minimally invasive device is applicable for providing treatment to the pulmonary system as well as the gastrointestinal tract.
- Treatment of the biliary and urinary system are also contemplated with wire guides and catheters, particularly adapted with the radiation source for treating the particular anatomical system.
Abstract
Description
- This invention relates to minimally invasive medical devices such as wire guides or catheters.
- In addition to balloon, angioplasty or laser ablation a coronary stent can be positioned in a treated vessel to maintain the patency of the vessel. However, one problem is that smooth muscle proliferates or intimal hyperplasia occurs in response to the presence of the stent in the vessel. As a result, restenosis of the vessel typically occurs within a period of six months.
- Another problem is that abrasion or dissection of the vessel wall may occur during a therapeutic procedure to reopen or enlarge the lumen of the vessel. As a result, thrombi formation and occlusion of the vessel lumen may also occur.
- These problems apply to parts of the vascular system other than coronary vessels, such as the occlusion of the femoral or iliac vessels.
- According to the invention there is provided a device as claimed in claim 1 or a method as defined in
claim 2. - The device can provide localized radiation treatment in a body passageway such as a coronary vessel in the vascular system. That decreases reproduction of intimal and smooth muscle cells to prevent or curtail intimal hyperplasia and smooth muscle proliferation. Advantageously, restenosis of the treated vessel is significantly minimized. The distal portion preferably has a distal end that is directable through the tortuous segments of coronary vessels.
-
- FIG.1 depicts the minimally invasive medical device of the present invention;
- FIG.2 depicts an enlarged view of the distal portion of the medical device of FIG.1;
- FIG.3 depicts an alternative enhancement to the minimally invasive medical device of FIG.1;
- FIG.4 depicts a second alternative enhancement to the minimally invasive medical device of FIG.1;
- FIG.5 depicts another aspect of the minimally invasive medical device of the present invention;
- FIG.6 depicts a second aspect of the minimally invasive medical device of the present invention; and
- FIG.7 depicts an enhancement to the distal portion of the medical device of FIG.1.
- Depicted in Fig.1 is preferred embodiment of an illustrative minimally invasive
medical device 10, such as a wire guide, for providing a radiation treatment in part of a body such as a passageway thereof. This minimally invasive medical device has particular application as a percutaneously inserted intravascular device for providing a radiation treatment to the area of a coronary vessel having, for example, a stent positioned therein.Device 10 comprises flexible elongated member 11 andradiation source 12. Flexible elongated member 11 includesproximal portion 13 anddistal portion 14. The distal portion is insertable in a body passageway such as a coronary artery of the vascular system and has adistal end 15 that is directable through the vascular system to the treatment site.Radiation source 12 comprises commercially available iridium radioactive material attached about or withindistal portion 14 as shown. -
Distal portion 14 includeswire coil 16 of commercially available 0.01cms (0.004") diameter stainless steel wire that is wound into a coil having an outside diameter of approximately 0.046cms (0.0183") to 0.048cms (0.019") and a length of approximately 6 to 9cms.Distal portion 14 has a predetermined longitudinal curvature such as approximately 90°longitudinal curvature 17 that extends for about 15mm fromdistal end 15. As a result,distal end 15 is directable through the body passageway.Wire coil 16 includesdistal end 18,proximal end 19, andpassageway 20 extending longitudinally therebetween. - Flexible elongated member 11 comprises a stainless steel mandril wire 21 having a uniform diameter of 0.046cms (0.018") about the
proximal portion 13. This uniform diameter is within a tolerance of - 0.0038cms (-0.0015") of the wire coil diameter. Mandril wire 21 is approximately 40cms in length and has a longitudinally tapereddistal end 22 for a length of approximately 15cms. Tapereddistal end 22 of the mandril wire is inserted throughpassageway 20 and attached todistal coil end 18 in a well-known manner by, for example,weld 24.Proximal coil end 19 is attached to tapereddistal end 22 in a well-known manner using, for example,soft solder 25. Flexible elongated member 11, known as a Cope Mandril wire guide, is commercially available from Cook Incorporated, Bloomington, Indiana. - Tapered
distal end 22 also includes anannular recess 23 circumferentially positioned thereabout approximately 10mm from directabledistal end 15.Radiation source 12 comprising a ring of commercially available iridium radioactive material is fixedly positioned inannular recess 23 for providing the radiation treatment. FIG.2 depicts an enlarged view ofannular recess 23 andradiation source 12 fixedly positioned therein. - Depicted in FIG.7 is
distal portion 66 of a minimally invasive medical device which includes an enhancement to the device of FIG.1.Distal portion 66 includesproximal wire coil 68 anddistal wire coil 69 having respective longitudinally extendingpassageways 70 and 71. The elongated flexible member of the device includes a mandril wire having tapereddistal end 72. The tapered distal end of the mandril wire extends longitudinally through the wire coil passageways. The distal ends of the mandril wire anddistal wire coil 69 are attached together using, for example,weld 76. This formsdirectable end 67 ofdistal portion 66 of the minimally invasive medical device. The medical device also includesradiation source 73 which is a tubular sleeve of commercially available iridium radioactive material positioned about tapereddistal end 72 of a mandril wire and betweenproximal wire coil 68 anddistal wire coil 69.Wire coils Proximal wire coil 68 is positioned over the tapered distal end of the mandril wire with the proximal end of the coil being affixed thereto with, for example, soft solder. Tubularsleeve radiation source 73 is positioned about the tapered distal end of the mandril wire next to the distal end ofproximal wire coil 68. The abutting ends of the proximal wire coil and tubular sleeve are affixed to tapereddistal end 72 of the mandril wire using, for example,soft solder 74.Distal wire coil 69 is positioned about the tapered distal end of the mandril wire abutting the proximal end of the tubular sleeve radiation source. The abutting ends of the distal wire coil and tubular sleeve are affixed to tapereddistal end 72 of the mandril wire using, for example,soft solder 75. - Depicted in FIG.3 is minimally invasive
medical device 26 which includes an alternative enhancement to the minimally invasive device of FIG.1.Medical device 26 includes flexibleelongated member 27 andradiation source 28. The flexible elongated member includesproximal portion 29 anddistal portion 30.Distal portion 30 haslongitudinal curvature 43 and directabledistal end 44. With this enhancement,mandril wire 31 hasdistal end 32 that is tapered a shorter distance of, for example, 7cms and extends only partially throughwire coil passageway 33 of wire coil 34. Wire coil 34 hasproximal end 40,distal end 41, andpassageway 33 extending longitudinally therebetween. The proximal end of the coil is attached to tapereddistal end 32 in a well-known manner using, for example,soft solder 42. A safetysecond wire 35 of, for example, 0.0076cms (0.003") by 0.02cms (0.008") rectangular stainless steel havingproximal end 36 anddistal end 37 is inserted intopassageway 33 of wire coil 34. The distal ends of the safety wire and wire coil are attached in a well-known manner using, for example,weld 38.Proximal end 36 of the safety wire extends throughpassageway 33 to tapereddistal end 32 ofmandril wire 31. Tapereddistal end 32 and proximalsafety wire end 36 are attached to wire coil 34 in a well-known manner using, for example,soft solder 39, as shown.Radiation source 28 comprising, for example, a sleeve of iridium radioactive material, is fixedly positioned about tapereddistal end 32 inwire coil passageway 33 proximal to solder joint 39. - Depicted in FIG.4 is minimally invasive
medical device 45 which is a second alternative enhancement to the device of FIG.1. Similar to the enhancement depicted in FIG.3,mandril wire 46 havingdistal end 47 is tapered a distance of, for example, 7cms, and extends only partially intopassageway 48 ofwire coil 49. However, safetysecond wire 50 having proximal end 51 and distal end 52 extends approximately the entire length ofwire coil passageway 48. Distal safety wire end 52 is attached todistal coil end 53 in a well-known manner using, for example,weld 54. Proximal safety wire end 51 and tapereddistal wire end 47 are attached to proximalwire coil end 55 in a well-known manner using, for example,soft solder 56.Radiation source 57 comprising, for example, a sleeve of iridium radioactive material, is fixedly positioned about safetysecond wire 50 in wire coil passageway 48 a predetermined distance, for example, 5mms from distal wire end 52 to permit controlled radiation of the affected area. This advantageously provides the distal portion with variable flexibility for atraumatic insertion of the device. - The proximal portion of the cylindrical first wire has a uniform diameter. The outer diameter of the distal portion wire coil and the proximal portion of the first wire are within a close tolerance of each other to minimize trauma and abrasion to the vessel wall during insertion to the affected vessel site.
- Minimally invasive
medical device 58, (FIG.5), such as a catheter, comprises elongatedmember tube 59 havingdistal portion 60,proximal portion 61, andpassageway 62 extending longitudinally therebetween. The device further comprisesradiation source 63 attached about the passageway ofdistal portion 60, and shown embedded intube 59 about 5mms fromend 64 of the tube.Radiation source 63 comprises a tubular sleeve of iridium radioactive material.Elongated member tube 59 is formed in a well-known manner from any of a number of commercially available plastic materials such as polyethylene, polyurethane, or polytetrafluorethylene. The device also includeswire guide 65 which is percutaneously inserted and guided into the vessel.Catheter 59 is then inserted over the wire guide and directed to the treatment site in the vessel. - Minimally invasive medical device 77, (FIG.6), such as a catheter, comprises elongated
member tube 78 havingdistal portion 79,proximal portion 80, and a passageway extending longitudinally therebetween. The device further comprisesradiation source 84 attached aboutdistal portion 79 in the passageway thereof betweenproximal wire coil 81 and distal wire coil 85. In particular,radiation source 84 comprises a tubular sleeve of iridium radioactive material having a passageway extending longitudinally betweenpassageways 82 and 86 of wire coils 81 and 85, respectively. The tubular sleeve radiation source is preferably fixedly positioned about the passageway of the elongated member tube between the proximal and distal wire coils 81 and 85 by adhesive to formjoints Elongated member tube 78 is formed from plastic materials. The flexible elongated member tube has an outer diameter of approximately 0.096cms (0.038") which is insertable intopassageway 89 of commercially available guidingcatheter 88. The minimally invasive medical device also includeswire guide 90 which is percutaneously inserted and guided into the desired coronary vessel. Flexibleelongated member tube 78 is then inserted over the wire guide and directed to the treatment site in the coronary vessel through the passageway of the guiding catheter. - It is to be understood that the above-described minimally invasive intravascular medical device for providing a radiation treatment in a body passageway is merely an illustrative embodiment of the principles of this invention and that alternative devices, instruments, or apparatus may be devised by those skilled in the art. In particular, it is contemplated that many commercially available wire guides and catheters may be modified to attach a radiation source about or in the distal end thereof for providing a radiation treatment to a body passageway and, in particular, preventing intimal hyperplasia and smooth muscle proliferation which causes stenosis or restenosis of the passageway. Although described as being particularly applicable to the vascular system using well-known percutaneous insertion techniques, it is contemplated that the minimally invasive device is applicable for providing treatment to the pulmonary system as well as the gastrointestinal tract. Treatment of the biliary and urinary system are also contemplated with wire guides and catheters, particularly adapted with the radiation source for treating the particular anatomical system.
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US647280 | 1991-01-29 | ||
US07/647,280 US5354257A (en) | 1991-01-29 | 1991-01-29 | Minimally invasive medical device for providing a radiation treatment |
EP95308296A EP0775505B1 (en) | 1991-01-29 | 1995-11-21 | A minimally invasive medical device for providing a radiation treatment |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0497495A2 true EP0497495A2 (en) | 1992-08-05 |
EP0497495A3 EP0497495A3 (en) | 1993-04-07 |
EP0497495B1 EP0497495B1 (en) | 1997-03-12 |
Family
ID=37023055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92300538A Expired - Lifetime EP0497495B1 (en) | 1991-01-29 | 1992-01-22 | A minimally invasive medical device |
Country Status (5)
Country | Link |
---|---|
US (1) | US5354257A (en) |
EP (1) | EP0497495B1 (en) |
JP (1) | JPH04309368A (en) |
CA (1) | CA2059900C (en) |
DE (1) | DE69218013T2 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0539165A1 (en) * | 1991-10-21 | 1993-04-28 | Robert E. Fischell | Inter-biliary duct stent |
WO1994026205A1 (en) * | 1993-05-06 | 1994-11-24 | Kernforschungszentrum Karlsruhe Gmbh | Vascular implant |
WO1995007732A1 (en) * | 1993-09-15 | 1995-03-23 | Mawad Michel E | Retrievable, shielded radiotherapy implant |
EP0724467A1 (en) * | 1993-05-04 | 1996-08-07 | Omnitron International Incorporated | Radioactive source wire, apparatus and treatment methods |
US5683345A (en) * | 1994-10-27 | 1997-11-04 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
FR2759914A1 (en) * | 1997-02-27 | 1998-08-28 | Concept Medical Service | Radiotherapy instrument for treating tumours in ENT region or lungs |
US5855546A (en) * | 1996-02-29 | 1999-01-05 | Sci-Med Life Systems | Perfusion balloon and radioactive wire delivery system |
US5865720A (en) * | 1997-03-06 | 1999-02-02 | Scimed Life Systems, Inc. | Expandable and retrievable radiation delivery system |
US5873811A (en) * | 1997-01-10 | 1999-02-23 | Sci-Med Life Systems | Composition containing a radioactive component for treatment of vessel wall |
US5879282A (en) * | 1997-01-21 | 1999-03-09 | Cordis A Johnson And Johnson Company | Catheter having an expandable radioactive source |
US5899882A (en) * | 1994-10-27 | 1999-05-04 | Novoste Corporation | Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient |
US5910102A (en) * | 1997-01-10 | 1999-06-08 | Scimed Life Systems, Inc. | Conversion of beta radiation to gamma radiation for intravascular radiation therapy |
US5951458A (en) * | 1996-02-29 | 1999-09-14 | Scimed Life Systems, Inc. | Local application of oxidizing agents to prevent restenosis |
US6013019A (en) * | 1998-04-06 | 2000-01-11 | Isostent, Inc. | Temporary radioisotope stent |
EP0972498A1 (en) * | 1995-12-05 | 2000-01-19 | Robert E. Fischell | Radioisotope stent with increased radiation field strength at the ends of the stent |
US6074339A (en) * | 1998-05-07 | 2000-06-13 | Medtronic Ave, Inc. | Expandable braid device and method for radiation treatment |
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Also Published As
Publication number | Publication date |
---|---|
CA2059900C (en) | 2003-10-21 |
US5354257A (en) | 1994-10-11 |
EP0497495B1 (en) | 1997-03-12 |
DE69218013T2 (en) | 1997-06-19 |
DE69218013D1 (en) | 1997-04-17 |
JPH04309368A (en) | 1992-10-30 |
EP0497495A3 (en) | 1993-04-07 |
CA2059900A1 (en) | 1992-07-30 |
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