EP0024313A1 - Method of residue-free dispensing of small amounts of liquid - Google Patents

Method of residue-free dispensing of small amounts of liquid Download PDF

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Publication number
EP0024313A1
EP0024313A1 EP80104407A EP80104407A EP0024313A1 EP 0024313 A1 EP0024313 A1 EP 0024313A1 EP 80104407 A EP80104407 A EP 80104407A EP 80104407 A EP80104407 A EP 80104407A EP 0024313 A1 EP0024313 A1 EP 0024313A1
Authority
EP
European Patent Office
Prior art keywords
piston
cylinder
liquid
micro
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP80104407A
Other languages
German (de)
French (fr)
Other versions
EP0024313B1 (en
Inventor
Bernd Dr. Zierenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Priority to AT80104407T priority Critical patent/ATE4290T1/en
Publication of EP0024313A1 publication Critical patent/EP0024313A1/en
Application granted granted Critical
Publication of EP0024313B1 publication Critical patent/EP0024313B1/en
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0203—Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • B01L3/0206—Burettes, i.e. for withdrawing and redistributing liquids through different conduits of the plunger pump type
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B7/00—Piston machines or pumps characterised by having positively-driven valving
    • F04B7/0003—Piston machines or pumps characterised by having positively-driven valving the distribution member forming both the inlet and discharge distributor for one single pumping chamber
    • F04B7/0015—Piston machines or pumps characterised by having positively-driven valving the distribution member forming both the inlet and discharge distributor for one single pumping chamber and having a slidable movement

Definitions

  • the invention relates to a micro-piston pump for the residue-free metering of small amounts of liquid.
  • Micro-piston pumps of this type can, for example, be used advantageously to supply a defined amount of medicinal substance to the atomizing plate of a piezoelectric atomizer (e.g. according to DE-OS 25 37 765).
  • the micro-piston pump according to the invention essentially consists of a capillary-like cylinder with a gas-tightly fitted piston, a two-way valve with inlet and outlet at the end of the cylinder opposite the piston head, and a control device which coordinates the piston movement and valve setting.
  • FIG. 1 shows the micro-piston pump in the initial state
  • Figure 2 shows the micro-piston pump in the filled state
  • FIG. 3 shows a vertical section through the middle of the lower part of the micro-piston pump, perpendicular to the section shown in FIG. 1.
  • the piston 1, preferably made of stainless steel, moves in the very narrow cylinder 2, which is made, for example, of glass or metal can.
  • the cylinder 2 ends in a valve block 4, for example made of a plastic, such as Teflon, into which the gas-tight valve slide 5, preferably made of stainless steel, extends as far as the stop 6; 7 can be moved.
  • the position of the constriction 8 of the valve slide 5 relative to the inlet 9 or outlet 10 results in a connection between the inlet or outlet and the cavity 11 of the cylinder.
  • the piston 1 is at its bottom dead center when the piston handle 12 abuts the cylinder.
  • the product of the clear cross-section of the barrel and the stroke between marks a and c determines the dosage.
  • the micro-piston pump according to the invention is preferably used for metering liquid quantities in the range from 10 to 50 ⁇ l, but can also be set up for larger or smaller volumes by changing the dimensions. It is ensured by the use of a sufficiently narrow cylinder that due to capillarity The air column between the piston and the liquid is retained even when the position of the filled micro-piston pump changes.
  • the rotary movement is replaced by an up and down movement.

Abstract

1. Process for metering small quantities of liquid without leaving a residue by means of a micro-piston pump having a capillary cylinder in which a piston, which fits in gastight manner therein, is mounted so as to be movable between a top dead centre and a bottom dead centre, the cylinder at its end located opposite the base of the piston opening into a twoway valve which connects the space in the cylinder alternately to an inlet and to an outlet (which connects the cylinder to the atmosphere during the first stage of the intake operation), characterised in that the piston and the valve are moved in such a way that, during the intake operation, first a defined quantity of air and then a defined quantity of liquid is transported into the cylinder, the quantity of air being such that, as the piston moves downwards to bottom dead centre, all the liquid is expelled through the outlet line.

Description

Die Erfindung betrifft eine Mikrokolbenpumpe für die rückstandsfreie Dosierung kleiner Flüssigkeitsmengen. Mikrokolbenpumpen dieser Art können beispielsweise mit Vorteil verwendet werden, um der Zerstäuberplatte eines piezoelektrischen Zerstäubers (z.B. nach der DE-OS 25 37 765) eine definierte Menge Arzneistoff zuzuführen.The invention relates to a micro-piston pump for the residue-free metering of small amounts of liquid. Micro-piston pumps of this type can, for example, be used advantageously to supply a defined amount of medicinal substance to the atomizing plate of a piezoelectric atomizer (e.g. according to DE-OS 25 37 765).

Die erfindungsgemäße Mikrokolbenpumpe besteht im wesentlichen aus einem kapillarenartigen Zylinder mit gasdicht eingepaßten Kolben, einem Zweiwegeventil mit Zu- und Ableitung an dem dem Kolbenboden gegenüberliegenden Ende des Zylinders sowie einer Steuerungsvorrichtung, welche Kolbenbewegung und Ventileinstellung koordiniert.The micro-piston pump according to the invention essentially consists of a capillary-like cylinder with a gas-tightly fitted piston, a two-way valve with inlet and outlet at the end of the cylinder opposite the piston head, and a control device which coordinates the piston movement and valve setting.

Eine typische Ausführungsform der Erfindung ist in Figur 1 und 2 dargestellt, wobei Figur 1 die Mikrokolbenpumpe im Ausgangszustand, Figur 2 die Mikrokolbenpumpe in gefülltem Zustand zeigt. Einen vertikalen Schnitt durch die Mitte des unteren Teils der Mikrokolbenpumpe, senkrecht zu dem in Figur 1 wiedergegebenen Schnitt, zeigt Figur 3. Der Kolben 1, vorzugsweise aus Edelstahl, bewegt sich in dem sehr engen Zylinder 2, der z.B. aus Glas oder Metall gefertigt sein kann. Der Zylinder 2 endet in einem Ventilblock 4, z.B. aus einem Kunststoff, etwa Teflon, in den der gasdicht schließende, vorzugsweise aus Edelstahl gefertigte Ventilschieber 5 jeweils bis zum Anschlag 6; 7 bewegt werden kann. Durch die Lage der Einschnürung 8 des Ventilschiebers 5 zu Einlaß 9 bzw. Auslaß 10 ergibt sich eine Verbindung zwischen dem Einlaß bzw. dem Auslaß und dem Hohlraum 11 des Zylinders. Der Kolben 1 befindet sich an seinem unteren Totpunkt, wenn der Kolbengriff 12 an den Zylinder anstößt. Das Produkt aus dem lichten Querschnitt des Zvlinders und dem Hub zwischen den Marken a und c bestimmt die Dosierung.A typical embodiment of the invention is shown in Figures 1 and 2, wherein Figure 1 shows the micro-piston pump in the initial state, Figure 2 shows the micro-piston pump in the filled state. FIG. 3 shows a vertical section through the middle of the lower part of the micro-piston pump, perpendicular to the section shown in FIG. 1. The piston 1, preferably made of stainless steel, moves in the very narrow cylinder 2, which is made, for example, of glass or metal can. The cylinder 2 ends in a valve block 4, for example made of a plastic, such as Teflon, into which the gas-tight valve slide 5, preferably made of stainless steel, extends as far as the stop 6; 7 can be moved. The position of the constriction 8 of the valve slide 5 relative to the inlet 9 or outlet 10 results in a connection between the inlet or outlet and the cavity 11 of the cylinder. The piston 1 is at its bottom dead center when the piston handle 12 abuts the cylinder. The product of the clear cross-section of the barrel and the stroke between marks a and c determines the dosage.

Die Bewegung von Kolben 1 und Ventilschieber 5 ist so gesteuert, daß es zu folgendem Bewegungsablauf kommt:

  • a) Bei geöffnetem Auslaß (Anschlag 7 liegt am Ventilblock) bewegt sich der Kolben 1 aus der in Figur 1 dargestellten Position in Richtung A, bis eine gewisse Menge Luft in den Zylinder hineingesaugt ist (die Stirnfläche des Kolbens befindet sich bei Marke a). Die Luftmenge ist so bemessen, daß sie mit Sicherheit beim Entleeren der Mikrokolbenpumpe alle Flüssigkeit aus dem Bentil und der Auslaßleitung hinaustreibt.
  • b) Im zweiten Schritt wird durch Verschieben des Ventilschiebers in Richtung D bis zum Anschlag die Verbindung zwischen dem Einlaß 9 (und damit dem Vorratsbehälter) und dem Zylinder freigegeben.
  • c) Der Kolben 1 wird in Richtung A weiterbewegt, bis das durch Hub- und Z--linderquerschnitt festgelegte Flüssigkeitsvolumen eingesaugt ist (Endeinstellung gemäß Figur 2; die Stirnfläche des Kolbens befindet sich bei Marke c).
  • d) Der Ventilschieber 5 wird bis zum Anschlag in Richtung C zurückgestellt, damit die Verbindung zwischen Zylinder 2 und Auslaß 10 geöffnet.
  • e) Der Kolben 1 bewegt sich bis zum umteren Totpunkt (Stellung gemäß Figur 1). Dabei wird zunächst die Flüssigkeit, dann die Luft aus dem Zylinder 2 ver--drängt und durch die Auslaßleitung hinausgetrieben. Die Luft wird zum Freiblasen des Ventils und der Auslaßleitung benutzt. Nach diesem Entleerungsvorgang ist wieder der Ausgangszustand erreicht.
The movement of piston 1 and valve slide 5 is controlled so that the following sequence of movements occurs:
  • a) With the outlet open (stop 7 is on the valve block), the piston 1 moves from the position shown in Figure 1 in direction A until a certain amount of air is sucked into the cylinder (the end face of the piston is at mark a). The amount of air is dimensioned so that it surely drives all liquid out of the bentile and the outlet line when emptying the micro-piston pump.
  • b) In the second step, the connection between the inlet 9 (and thus the reservoir) and the cylinder is released by moving the valve slide in the direction D up to the stop.
  • c) The piston 1 is moved in the direction A until the liquid volume defined by the stroke and cylinder cross section is sucked in (final setting according to FIG. 2; the end face of the piston is at mark c).
  • d) The valve slide 5 is reset as far as possible in direction C, so that the connection between cylinder 2 and outlet 10 is opened.
  • e) The piston 1 moves to the rear dead center (position according to FIG. 1). First the liquid, then the air is displaced from cylinder 2 and driven out through the outlet line. The air is used to blow free the valve and the outlet line. After this emptying process, the initial state is reached again.

Die erfindungsgemäße Mikrokolbenpumpe dient bevorzugt zur Dosierung vom Flüssigkeitsmengen im Bereich von 10 bis 50 µl, kann jedoch durch Änderung der Abmessungen auch für größere oder kleinere Volumina eingerichtet werden. Dabei wird durch die Verwendung eines hinreichend engen Zylinders dafür gesorgt, daß infolge der Kapillarität auch bei Lageveränderungen der gefüllten Mikrokolbenpumpe die Luftsäule zwischen Kolben und Flüssigkeit erhalten bleibt.The micro-piston pump according to the invention is preferably used for metering liquid quantities in the range from 10 to 50 μl, but can also be set up for larger or smaller volumes by changing the dimensions. It is ensured by the use of a sufficiently narrow cylinder that due to capillarity The air column between the piston and the liquid is retained even when the position of the filled micro-piston pump changes.

Die Steuerung des oben beschriebenen Bewegungsablaufes kann im einfachsten Fall von Hand erfolgen. Verwendbar sind aber auch an sich bekannte mechanische oder elektrische Mittel. Eine einfache Vorrichtung für diesen Zweck besteht aus einer Kombination von Zahnrädern, Zahnstangen und Hebeln, die folgendermaßen aufgebaut ist:

  • Vier Zahnräder sind nebeneinander angeordnet und starr miteinander verbunden. Der Umfang der Zahnräder ist nur teilweise mit Zähnen besetzt, und zwar derart, daß zu einem bestimmten Zeitpunkt im wesentlichen nur ein Zahnrad wirksam wird. Während also beispielsweise das erste Zahnrad über eine Zahnstange und Hebel den Vorgang a) bewirkt, laufen die drei anderen frei mit, bis die gewünschte Luftmenge in den Zylinder gelangt ist. Dann sorgt das zweite Zahnrad für die Verstellung des Ventilschiebers, während gleichzeitig das erste Zahnrad den Kolben auf den oberen Totpunkt hin bewegt. Von da an läuft Zahnrad 1 frei mit, ein drittes Zahnrad bringt den Ventilschieber in die Auslaßstellung. Danach übernimmt es das vierte Zahnrad mit den zugehörigen Ubertragungselementen, den Kolben zum unteren Totpunkt zu bewegen. Die Steuerungsmechanik ist so ausgelegt, daß sich nach einer Drehung der Zahnräder um 360° alle Elemente wieder in der Ausgangsposition befinden.
In the simplest case, the movement sequence described above can be controlled by hand. However, mechanical or electrical means known per se can also be used. A simple device for this purpose consists of a combination of gears, racks and levers, which is constructed as follows:
  • Four gears are arranged side by side and rigidly connected to each other. The circumference of the gears is only partially covered with teeth, in such a way that only one gear becomes effective at a certain point in time. For example, while the first gearwheel effects the process a) via a rack and lever, the other three run freely until the desired amount of air has entered the cylinder. Then the second gear ensures the adjustment of the valve spool, while at the same time the first gear moves the piston towards top dead center. From then on, gear 1 runs freely, a third gear brings the valve spool into the outlet position. Then the fourth gearwheel with the associated transmission elements takes over to move the piston to the bottom dead center. The control mechanism is designed so that after rotating the gearwheels through 360 °, all elements are in the starting position again.

In einer anderen Ausführungsform der Steuerungsvorrichtung ist die Drehbewegung durch eine Auf- und Abbewegung ersetzt.In another embodiment of the control device, the rotary movement is replaced by an up and down movement.

Hierzu kann es vorteilhaft sein, Zylinder und Ventil so anzuordnen, daß die Bewegungsrichtungen von Kolben und Ventilschieber parallel verlaufen.To this end, it can be advantageous to arrange the cylinder and valve so that the directions of movement of the piston and valve slide are parallel.

Claims (2)

1. Mikrokolbenpumpe für die rückstandsfreie Dosierung kleiner Flüssigkeitsmengen, dadurch gekennzeichnet, daß sie einen kapillaren Zylinder aufweist, in dem ein gasdicht eingepaßter Kolben zwischen einem oberen und einem unteren Totpunkt beweglich angeordnet ist, daß der Zylinder an seinem dem Kolbenboden gegenüberliegenden Ende in ein Zweiwegeventil mündet, das den Zylinderhohlraum wechselweise mit einem Einlaß und einem Auslaß verbindet, wobei die Kolbenbewegungen und die Ventileinstellung durch an sich bekannte Steuerungselemente so koordiniert werden, daß während des Ansaugvorgangs zunächst Luft und danach eine definierte Flüssigkeitsmenge in den Zylinder transportiert wird, die bei der Abwärtsbewegung des Kolbens bis zum unteren Totpunkt rückstandsfrei durch die Auslaßleitung abgegeben wird.1. Micro piston pump for residue-free metering of small amounts of liquid, characterized in that it has a capillary cylinder in which a gas-tight piston is movably arranged between an upper and a lower dead center, that the cylinder opens into a two-way valve at its end opposite the piston head , which alternately connects the cylinder cavity to an inlet and an outlet, the piston movements and the valve setting being coordinated by control elements known per se in such a way that, during the suction process, first air and then a defined quantity of liquid are transported into the cylinder, which is released during the downward movement of the Piston is discharged without residue through the outlet line to the bottom dead center. 2. Mikrokolbenpumpe nach Anspruch 1, dadurch gekennzeichnet, daß der Hohlraum des Zylinders einen solchen Durchmesser aufweist, daß infolge der Kapillarität auch bei Lageveränderungen der Mikrokolbenpumpe die Luftsäule zwischen Kolbenboden und Flüssigkeit erhalten bleibt.2. Micro-piston pump according to claim 1, characterized in that the cavity of the cylinder has such a diameter that the air column between the piston crown and the liquid is retained due to the capillarity even when the micro-piston pump changes position.
EP80104407A 1979-08-20 1980-07-26 Method of residue-free dispensing of small amounts of liquid Expired EP0024313B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT80104407T ATE4290T1 (en) 1979-08-20 1980-07-26 PROCESS FOR RESIDUE-FREE DOSING OF SMALL QUANTITIES OF LIQUID.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2933617 1979-08-20
DE19792933617 DE2933617A1 (en) 1979-08-20 1979-08-20 MICRO PISTON PUMP

Publications (2)

Publication Number Publication Date
EP0024313A1 true EP0024313A1 (en) 1981-03-04
EP0024313B1 EP0024313B1 (en) 1983-07-27

Family

ID=6078839

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EP80104407A Expired EP0024313B1 (en) 1979-08-20 1980-07-26 Method of residue-free dispensing of small amounts of liquid

Country Status (14)

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EP (1) EP0024313B1 (en)
JP (1) JPS5632082A (en)
AT (1) ATE4290T1 (en)
AU (1) AU544213B2 (en)
CA (1) CA1152379A (en)
DE (2) DE2933617A1 (en)
DK (1) DK147844C (en)
ES (1) ES8105829A1 (en)
FI (1) FI67434C (en)
IE (1) IE50187B1 (en)
IL (1) IL60854A0 (en)
NO (1) NO155358C (en)
NZ (1) NZ194707A (en)
ZA (1) ZA805103B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031357A2 (en) * 2000-10-10 2002-04-18 Beckman Coulter, Inc. Fluid-moving device with integrated valve
CN109573124A (en) * 2018-12-29 2019-04-05 河南官渡生物工程有限公司 The plunger pump of adjustable filling amount for veterinary drug production

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE125606C (en) *
DE254111C (en) *
US3299827A (en) * 1964-04-29 1967-01-24 Snam Spa Micropump head
FR2319117A1 (en) * 1975-07-25 1977-02-18 Pasteur Institut Syringe for use with small quantities of liquid - measures quantity by displacement of calibrated wire inside a capillary tube
US4022065A (en) * 1976-02-19 1977-05-10 Ramin James A Calibrated sample delivery apparatus accommodating offset error
US4061037A (en) * 1976-09-20 1977-12-06 Keegan William P Pipettes
US4091677A (en) * 1976-12-23 1978-05-30 Nichiryo Co., Ltd. Pipetting apparatus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4935904A (en) * 1972-08-09 1974-04-03
JPS541422A (en) * 1977-06-06 1979-01-08 Citizen Watch Co Ltd Fixed quantity of liquid supplying device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE125606C (en) *
DE254111C (en) *
US3299827A (en) * 1964-04-29 1967-01-24 Snam Spa Micropump head
FR2319117A1 (en) * 1975-07-25 1977-02-18 Pasteur Institut Syringe for use with small quantities of liquid - measures quantity by displacement of calibrated wire inside a capillary tube
US4022065A (en) * 1976-02-19 1977-05-10 Ramin James A Calibrated sample delivery apparatus accommodating offset error
US4061037A (en) * 1976-09-20 1977-12-06 Keegan William P Pipettes
US4091677A (en) * 1976-12-23 1978-05-30 Nichiryo Co., Ltd. Pipetting apparatus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031357A2 (en) * 2000-10-10 2002-04-18 Beckman Coulter, Inc. Fluid-moving device with integrated valve
WO2002031357A3 (en) * 2000-10-10 2002-09-06 Beckman Coulter Inc Fluid-moving device with integrated valve
CN109573124A (en) * 2018-12-29 2019-04-05 河南官渡生物工程有限公司 The plunger pump of adjustable filling amount for veterinary drug production

Also Published As

Publication number Publication date
AU6156880A (en) 1981-04-09
FI67434C (en) 1985-03-11
FI802588A (en) 1981-02-21
NO155358B (en) 1986-12-08
CA1152379A (en) 1983-08-23
ZA805103B (en) 1982-04-28
DK147844B (en) 1984-12-24
FI67434B (en) 1984-11-30
IL60854A0 (en) 1980-10-26
DK147844C (en) 1985-06-03
AU544213B2 (en) 1985-05-23
IE50187B1 (en) 1986-03-05
DE2933617A1 (en) 1981-03-26
NZ194707A (en) 1984-11-09
JPS5632082A (en) 1981-04-01
DK356980A (en) 1981-02-21
NO802439L (en) 1981-02-23
IE801752L (en) 1981-02-20
ES494358A0 (en) 1981-06-16
EP0024313B1 (en) 1983-07-27
NO155358C (en) 1987-03-18
ATE4290T1 (en) 1983-08-15
ES8105829A1 (en) 1981-06-16
DE3064407D1 (en) 1983-09-01

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