DE733059T1 - Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen - Google Patents

Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen

Info

Publication number
DE733059T1
DE733059T1 DE0733059T DE95905337T DE733059T1 DE 733059 T1 DE733059 T1 DE 733059T1 DE 0733059 T DE0733059 T DE 0733059T DE 95905337 T DE95905337 T DE 95905337T DE 733059 T1 DE733059 T1 DE 733059T1
Authority
DE
Germany
Prior art keywords
polynucleotide
connections
location
eukaryotic cells
specific mutation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0733059T
Other languages
English (en)
Inventor
Eric B Kmiec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of DE733059T1 publication Critical patent/DE733059T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
DE0733059T 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen Pending DE733059T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16430393A 1993-12-09 1993-12-09
PCT/US1994/014181 WO1995015972A1 (en) 1993-12-09 1994-12-09 Compounds and methods for site-directed mutations in eukaryotic cells

Publications (1)

Publication Number Publication Date
DE733059T1 true DE733059T1 (de) 1997-08-28

Family

ID=22593886

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69425903T Expired - Fee Related DE69425903T2 (de) 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen
DE0733059T Pending DE733059T1 (de) 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69425903T Expired - Fee Related DE69425903T2 (de) 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen

Country Status (15)

Country Link
US (3) US5565350A (de)
EP (1) EP0733059B1 (de)
JP (1) JP3585238B2 (de)
KR (1) KR100386337B1 (de)
CN (2) CN1048254C (de)
AT (1) ATE196311T1 (de)
AU (1) AU691550B2 (de)
CA (1) CA2178729A1 (de)
DE (2) DE69425903T2 (de)
DK (1) DK0733059T3 (de)
ES (1) ES2149962T3 (de)
GR (1) GR3034988T3 (de)
NZ (1) NZ278490A (de)
PT (1) PT733059E (de)
WO (1) WO1995015972A1 (de)

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AU1399595A (en) 1995-06-27
US5565350A (en) 1996-10-15
US5756325A (en) 1998-05-26
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CN1215755A (zh) 1999-05-05
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JP3585238B2 (ja) 2004-11-04
DE69425903D1 (de) 2000-10-19
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ATE196311T1 (de) 2000-09-15
AU691550B2 (en) 1998-05-21
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