DE69919701D1 - Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie - Google Patents

Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie

Info

Publication number
DE69919701D1
DE69919701D1 DE69919701T DE69919701T DE69919701D1 DE 69919701 D1 DE69919701 D1 DE 69919701D1 DE 69919701 T DE69919701 T DE 69919701T DE 69919701 T DE69919701 T DE 69919701T DE 69919701 D1 DE69919701 D1 DE 69919701D1
Authority
DE
Germany
Prior art keywords
multimers
exchange chromatography
separation
ion exchange
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69919701T
Other languages
English (en)
Other versions
DE69919701T2 (de
Inventor
Deborah Ansaldi
Philip Lester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22206161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69919701(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE69919701D1 publication Critical patent/DE69919701D1/de
Application granted granted Critical
Publication of DE69919701T2 publication Critical patent/DE69919701T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
DE69919701T 1998-06-01 1999-05-24 Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie Revoked DE69919701T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8760298P 1998-06-01 1998-06-01
US87602P 1998-06-01
PCT/US1999/011598 WO1999062936A1 (en) 1998-06-01 1999-05-24 Separation of protein monomers from aggregates by use of ion-exchange chromatography

Publications (2)

Publication Number Publication Date
DE69919701D1 true DE69919701D1 (de) 2004-09-30
DE69919701T2 DE69919701T2 (de) 2005-09-15

Family

ID=22206161

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919701T Revoked DE69919701T2 (de) 1998-06-01 1999-05-24 Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie

Country Status (13)

Country Link
US (2) US6620918B2 (de)
EP (2) EP1500661A1 (de)
JP (3) JP2002517406A (de)
AT (1) ATE274522T1 (de)
AU (1) AU750977B2 (de)
CA (1) CA2333747C (de)
DE (1) DE69919701T2 (de)
DK (1) DK1084136T3 (de)
ES (1) ES2228052T3 (de)
HK (1) HK1037879A1 (de)
IL (2) IL139609A (de)
PT (1) PT1084136E (de)
WO (1) WO1999062936A1 (de)

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CN107531750B (zh) * 2015-04-28 2021-03-16 深圳翰宇药业股份有限公司 多肽混合物高效液相色谱分析方法
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Also Published As

Publication number Publication date
US20020010319A1 (en) 2002-01-24
EP1500661A1 (de) 2005-01-26
CA2333747C (en) 2008-02-19
EP1084136A1 (de) 2001-03-21
JP2002517406A (ja) 2002-06-18
HK1037879A1 (en) 2002-02-22
AU750977B2 (en) 2002-08-01
US20040116674A1 (en) 2004-06-17
ATE274522T1 (de) 2004-09-15
DK1084136T3 (da) 2005-01-03
IL139609A (en) 2006-06-11
CA2333747A1 (en) 1999-12-09
WO1999062936A1 (en) 1999-12-09
US6620918B2 (en) 2003-09-16
AU4205999A (en) 1999-12-20
IL173432A0 (en) 2006-06-11
DE69919701T2 (de) 2005-09-15
IL139609A0 (en) 2002-02-10
EP1084136B1 (de) 2004-08-25
JP2006071646A (ja) 2006-03-16
JP2004175806A (ja) 2004-06-24
ES2228052T3 (es) 2005-04-01
PT1084136E (pt) 2004-12-31

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8331 Complete revocation