DE69840630D1 - Kapillar-ventil-verbindungsstück und die flu richtung bestimmendes kapillar-element - Google Patents

Kapillar-ventil-verbindungsstück und die flu richtung bestimmendes kapillar-element

Info

Publication number
DE69840630D1
DE69840630D1 DE69840630T DE69840630T DE69840630D1 DE 69840630 D1 DE69840630 D1 DE 69840630D1 DE 69840630 T DE69840630 T DE 69840630T DE 69840630 T DE69840630 T DE 69840630T DE 69840630 D1 DE69840630 D1 DE 69840630D1
Authority
DE
Germany
Prior art keywords
fibers
capillary
face
flu
direction determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69840630T
Other languages
English (en)
Inventor
Stevan B Jovanovich
Gregory J Ronan
David J Roach
Richard F Johnston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences AB
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Bio Sciences AB, GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences AB
Application granted granted Critical
Publication of DE69840630D1 publication Critical patent/DE69840630D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6034Construction of the column joining multiple columns
    • G01N30/6039Construction of the column joining multiple columns in series
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6052Construction of the column body
    • G01N30/6073Construction of the column body in open tubular form
    • G01N30/6078Capillaries
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/26Optical coupling means
    • G02B6/35Optical coupling means having switching means
    • G02B6/3502Optical coupling means having switching means involving direct waveguide displacement, e.g. cantilever type waveguide displacement involving waveguide bending, or displacing an interposed waveguide between stationary waveguides
    • G02B6/3504Rotating, tilting or pivoting the waveguides, or with the waveguides describing a curved path
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/381Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/3869Mounting ferrules to connector body, i.e. plugs
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/40Mechanical coupling means having fibre bundle mating means
    • G02B6/403Mechanical coupling means having fibre bundle mating means of the ferrule type, connecting a pair of ferrules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0832Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838Capillaries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0622Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0644Valves, specific forms thereof with moving parts rotary valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56Labware specially adapted for transferring fluids
    • B01L3/561Tubes; Conduits
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56Labware specially adapted for transferring fluids
    • B01L3/565Seals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8827Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N30/16Injection
    • G01N30/20Injection using a sampling valve
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N30/24Automatic injection systems
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/26Optical coupling means
    • G02B6/35Optical coupling means having switching means
    • G02B6/354Switching arrangements, i.e. number of input/output ports and interconnection types
    • G02B6/35543D constellations, i.e. with switching elements and switched beams located in a volume
    • G02B6/35581xN switch, i.e. one input and a selectable single output of N possible outputs
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/381Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres
    • G02B6/3818Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres of a low-reflection-loss type
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/381Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres
    • G02B6/3825Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres with an intermediate part, e.g. adapter, receptacle, linking two plugs
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/3833Details of mounting fibres in ferrules; Assembly methods; Manufacture
    • G02B6/3851Ferrules having keying or coding means
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/3833Details of mounting fibres in ferrules; Assembly methods; Manufacture
    • G02B6/3854Ferrules characterised by materials
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/3873Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls
    • G02B6/3874Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls using tubes, sleeves to align ferrules
    • G02B6/3877Split sleeves
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/3873Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls
    • G02B6/3874Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls using tubes, sleeves to align ferrules
    • G02B6/3878Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls using tubes, sleeves to align ferrules comprising a plurality of ferrules, branching and break-out means
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/3887Anchoring optical cables to connector housings, e.g. strain relief features
    • G02B6/38875Protection from bending or twisting
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/36Mechanical coupling means
    • G02B6/38Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807Dismountable connectors, i.e. comprising plugs
    • G02B6/389Dismountable connectors, i.e. comprising plugs characterised by the method of fastening connecting plugs and sockets, e.g. screw- or nut-lock, snap-in, bayonet type
    • G02B6/3894Screw-lock type
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/86493Multi-way valve unit
    • Y10T137/86549Selective reciprocation or rotation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer
DE69840630T 1997-09-11 1998-09-08 Kapillar-ventil-verbindungsstück und die flu richtung bestimmendes kapillar-element Expired - Lifetime DE69840630D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/927,645 US6190616B1 (en) 1997-09-11 1997-09-11 Capillary valve, connector, and router
PCT/US1998/018634 WO1999013312A1 (en) 1997-09-11 1998-09-08 Capillary valve, connector, and router

Publications (1)

Publication Number Publication Date
DE69840630D1 true DE69840630D1 (de) 2009-04-16

Family

ID=25455040

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69840630T Expired - Lifetime DE69840630D1 (de) 1997-09-11 1998-09-08 Kapillar-ventil-verbindungsstück und die flu richtung bestimmendes kapillar-element

Country Status (7)

Country Link
US (2) US6190616B1 (de)
EP (1) EP1019694B1 (de)
JP (1) JP2001516048A (de)
AT (1) ATE424552T1 (de)
DE (1) DE69840630D1 (de)
ES (1) ES2321350T3 (de)
WO (1) WO1999013312A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369363A1 (en) * 1999-04-29 2000-11-09 Marcy Engelstein Device for rapid dna sample processing with integrated liquid handling, thermocycling, and purification
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CN1416365A (zh) 2000-02-22 2003-05-07 基因谱公司 微阵列制造技术及设备
KR20020097181A (ko) 2000-02-22 2002-12-31 제노스펙트라 인코포레이티드 마이크로어레이 제작 기술 및 장치
DE10014962A1 (de) * 2000-03-25 2001-10-04 Gsf Forschungszentrum Umwelt Pulsbares Kapillarventil
US6599441B1 (en) * 2000-07-18 2003-07-29 Emerald Biostructures, Inc. Crystallization solutions
US7588641B2 (en) * 2001-08-30 2009-09-15 Hamamatsu Photonics K.K. Method of forming liquid-drops of mixed liquid, and device for forming liquid-drops of mixed liquid
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
US20050074211A1 (en) * 2002-01-24 2005-04-07 Daniel Greub Sleeve receiving element for the coupling of an optical plug-type connector
US7288228B2 (en) * 2002-02-12 2007-10-30 Gilson, Inc. Sample injection system
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
US6923907B2 (en) * 2002-02-13 2005-08-02 Nanostream, Inc. Separation column devices and fabrication methods
US8241883B2 (en) * 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
WO2004022233A1 (en) * 2002-09-06 2004-03-18 Epigem Limited Modular microfluidic system
DE10393203B4 (de) * 2002-09-12 2017-12-14 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Kapillarverbindungsfassung und Verfahren zum Halten einer Kapillarverrohrung
JP2006512092A (ja) 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
US7311882B1 (en) 2003-01-24 2007-12-25 Sandia National Laboratories Capillary interconnect device
US6832787B1 (en) 2003-01-24 2004-12-21 Sandia National Laboratories Edge compression manifold apparatus
US6966336B1 (en) 2003-01-24 2005-11-22 Sandia National Laboratories Fluid injection microvalve
US6918573B1 (en) 2003-01-27 2005-07-19 Sandia National Laboratories Microvalve
US7553455B1 (en) 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
US6926313B1 (en) 2003-04-02 2005-08-09 Sandia National Laboratories High pressure capillary connector
EP1636823A4 (de) * 2003-05-29 2007-11-21 Upchurch Scient Inc Verbesserte vorrichtungen und verfahren für elektrospray-anwendungen
US7018108B2 (en) * 2003-06-24 2006-03-28 Molex Incorporated Rotationally adjustable fiber optic connector
EP2322278B1 (de) 2003-10-24 2017-01-04 Aushon Biosystems, Inc. Vorrichtung und Verfahren zur Ausgabe von flüssigen, halbflüssigen und festen Proben
AU2005206920B2 (en) * 2004-01-16 2011-04-14 Osteobiologics, Inc. Bone-tendon-bone implant
US20050257885A1 (en) * 2004-05-24 2005-11-24 Nanostream, Inc. Capillary multi-channel optical flow cell
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
EP1611954A1 (de) * 2004-07-03 2006-01-04 Roche Diagnostics GmbH Verbindungsstück zwischen Flüssigkeitsbehältern
EP2261650A3 (de) * 2004-09-15 2011-07-06 IntegenX Inc. Mikrofluidische Vorrichtungen
US7745207B2 (en) 2006-02-03 2010-06-29 IntegenX, Inc. Microfluidic devices
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
WO2007021813A2 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic system and methods
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US8841116B2 (en) * 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US9011382B2 (en) * 2006-11-22 2015-04-21 Becton, Dickinson And Company Vascular access device blood sealing and exposure prevention
US20110039303A1 (en) * 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
CN101990516B (zh) 2008-01-22 2015-09-09 英特基因有限公司 多用试样准备系统及其在集成分析系统中的使用
CH702498B1 (de) * 2008-05-13 2011-07-15 Ctc Analytics Ag Probenaufgabe- und Reinigungseinrichtung für HPLC-Geräte.
WO2009146290A1 (en) * 2008-05-30 2009-12-03 Waters Technologies Corporation Device and method for connecting fluid conduits
US7881569B2 (en) * 2008-06-17 2011-02-01 Princetel, Inc. Two-channel plastic optical fiber (POF) rotary joint
WO2010077322A1 (en) 2008-12-31 2010-07-08 Microchip Biotechnologies, Inc. Instrument with microfluidic chip
US8062064B2 (en) * 2009-05-11 2011-11-22 Belden Inc. Modular nut assembly having textured ring
EP2438154A1 (de) 2009-06-02 2012-04-11 Integenx Inc. Fluidische vorrichtung mit membranventilen
AU2010256429B2 (en) 2009-06-05 2015-09-17 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2378342A1 (de) * 2010-04-15 2011-10-19 Mmi Ag Mikromanipulationssystem mit Schutzvorrichtung für Kapillaren
CA3016967C (en) 2010-04-16 2021-08-31 Opko Diagnostics, Llc Systems and devices for analysis of samples
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
EP2606242A4 (de) 2010-08-20 2016-07-20 Integenx Inc Mikrofluidikvorrichtungen mit mechanisch abgedichteten membranventilen
AU2011305480A1 (en) * 2010-09-22 2013-05-23 Perkinelmer Health Sciences, Inc. Backflush methods and devices for chromatography
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
JP5873760B2 (ja) * 2012-05-25 2016-03-01 矢崎総業株式会社 光コネクタ
KR101414048B1 (ko) * 2012-10-09 2014-07-02 디지탈 지노믹스(주) 반응 용기 내로 액체를 선택적으로 주입하는 장치 및 이를 포함하는 바이오 센서
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US10481341B2 (en) * 2014-08-14 2019-11-19 CommScope Connectivity Belgium BVBA Fiber optic adapter assembly
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
CN106291826B (zh) * 2015-05-20 2019-05-28 华为技术有限公司 插头防护帽、光纤连接头组件、光纤插头及网络设备
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
WO2016206594A1 (zh) 2015-06-23 2016-12-29 爱德奇电讯国际贸易(上海)有限公司 光纤连接器组件
EP3368668B1 (de) 2015-10-28 2023-11-29 Silicon Valley Scientific, Inc. Verfahren und vorrichtung zur codierung von zellularen räumlichen positionsinformationen
USD923817S1 (en) * 2016-03-30 2021-06-29 Princeton Biochemicals, Inc Analyte concentrator-microreactor device
US11231347B2 (en) 2016-11-29 2022-01-25 S2 Genomics, Inc. Method and apparatus for processing tissue samples
JP7101764B2 (ja) 2017-05-22 2022-07-15 スミスズ インターコネクト アメリカズ インコーポレイテッド 乾式はめ合わせ回転コネクタ
US10890595B2 (en) 2017-10-12 2021-01-12 Visiongate, Inc. Method and apparatus for pre-positioning a radially symmetric, coaxial sample within a sheath fluid to provide uniform sample delivery rate during flow
CN107602874B (zh) * 2017-11-01 2020-09-11 中国药科大学 一种基于微流控技术合成金属有机骨架材料的方法
US10422965B2 (en) 2018-01-26 2019-09-24 Steve Cheng Fiber optic connector
CA3102089A1 (en) 2018-06-01 2019-12-05 S2 Genomics, Inc. Method and apparatus for processing tissue samples
EP3914907A4 (de) * 2019-01-25 2022-10-26 ProteinSimple Wiederverwendbare kartusche für kapillarelektrophorese
USD919833S1 (en) * 2019-03-06 2021-05-18 Princeton Biochemicals, Inc Micro valve for controlling path of fluids in miniaturized capillary connections
EP3730982A1 (de) 2019-04-25 2020-10-28 DoseVue NV Verbindungsvorrichtung für optische fasern
US11512908B2 (en) 2020-02-03 2022-11-29 Hamilton Sundstrand Corporation Evaporator with grooved channels
US11808528B2 (en) * 2020-02-03 2023-11-07 Hamilton Sundstrand Corporation Evaporator with grooved channels and orifice inserts

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3071155A (en) * 1961-08-15 1963-01-01 Danley Dayton Herschel Rotary valve for fluid operated musical instruments
SE330624B (de) * 1965-09-02 1970-11-23 Medicinskkemiska Lab Calab Ab
US3570314A (en) * 1967-08-28 1971-03-16 Maurice Wagner Valving arrangement for automated materials analysis
US4027945A (en) * 1976-03-04 1977-06-07 The United States Of America As Represented By The Secretary Of The Navy Optical sliprings
US4401365A (en) * 1980-02-08 1983-08-30 Hitachi, Ltd. Rotary type optical switch
GB2091899B (en) * 1980-12-16 1984-04-18 Kokusai Denshin Denwa Co Ltd Rotary joints for optical fibres
SE436931B (sv) * 1980-12-19 1985-01-28 Asea Ab Metsignaloverforingsanordning for signaler mellan en roterande del och en rotationsstatisk del
US4492427A (en) * 1981-03-09 1985-01-08 Litton Systems, Inc. Optical slip ring assembly
US4445391A (en) * 1981-10-19 1984-05-01 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US4507977A (en) * 1981-10-19 1985-04-02 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US4529230A (en) * 1982-02-26 1985-07-16 Supelco, Inc. Capillary tubing and small rod connector
US4448214A (en) * 1982-11-22 1984-05-15 Alessio Lawrence M D Multi-channel laminar-flow fluid valve
CH674580A5 (de) * 1983-10-06 1990-06-15 Contraves Ag
JPS6196441A (ja) * 1984-10-17 1986-05-15 Idemitsu Kosan Co Ltd 見掛粘度測定装置
US4632149A (en) * 1984-12-10 1986-12-30 Uop Inc. Rotary valve for interconnecting conduits
DE3688142T2 (de) * 1985-01-25 1993-07-22 Mallinckrodt Sensor Syst Geraet zum nachweis oder zur messung von chemischen komponenten.
US4702889A (en) * 1986-01-16 1987-10-27 Coulter Electronics Inc. Liquid sampling valve
US4822569A (en) * 1986-06-09 1989-04-18 Fisher Scientific Company Rotary shear valve with cleaning feature and method of using same
DE3825080A1 (de) * 1988-07-23 1990-01-25 Putzmeister Maschf Vorrichtung und verfahren zum verteilen von pumpfaehigen dickstoffen in mehrere foerderleitungen
US4953932A (en) * 1989-04-25 1990-09-04 Hughes Aircraft Company Optical slip ring
US4948565A (en) * 1989-04-25 1990-08-14 Fisher Scientific Company Analytical system
JP2624328B2 (ja) * 1989-05-19 1997-06-25 日本電気 株式会社 光合波分波器
DE3921829A1 (de) * 1989-07-03 1991-01-17 Gerhard Gramm Verteilervorrichtung
US5205845A (en) * 1990-09-28 1993-04-27 The Regents Of The University Of Michigan Mechanical gas chromatography injection valves and column multiplexing techniques
DE59105165D1 (de) * 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
US5158751A (en) * 1990-12-13 1992-10-27 Coulter Corporation Liquid metering and transfer valve assembly
US5207643A (en) * 1991-05-08 1993-05-04 Ballard Medical Products Multi-lumen-catheter flow valve system
US5208466A (en) * 1991-10-08 1993-05-04 Beckman Instruments, Inc. Apparatus and method for aligning capillary column and detection optics
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
DE4235860C2 (de) * 1992-10-26 1998-07-09 Mann & Hummel Filter Rohrweiche
US5288113A (en) 1992-12-24 1994-02-22 Restek Corporation Connector for capillary tubes having a tapered inner bore
US5389221A (en) 1993-03-09 1995-02-14 The University Of North Carolina At Chapel Hill Two dimensional separation system
EP0617278A1 (de) 1993-03-12 1994-09-28 Orion Research, Incorporated Kapillarverbindungen zur Anwendung bei Trennverfahren
JPH06265447A (ja) * 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
JPH07253521A (ja) * 1993-09-27 1995-10-03 Toto Ltd 光ファイバコネクタ用キャピラリ及びその製造方法
JPH07107962A (ja) * 1993-10-12 1995-04-25 Hitachi Ltd 毛細管を用いた核酸増幅装置
US5438638A (en) * 1994-04-05 1995-08-01 Tektronix, Inc. Electrically controlled mechanical optical switch
US5492555A (en) 1994-06-09 1996-02-20 Lovelace Biomedical & Environmental Research Institute, Inc. Automated two-dimensional interface for capillary gas chromatography
US5453170A (en) 1994-09-26 1995-09-26 Ati Orion Off-column detector for ion separation techniques
US5540464A (en) 1994-10-04 1996-07-30 J&W Scientific Incorporated Capillary connector
US5487569A (en) 1994-10-12 1996-01-30 Restek Corporation Connector for three or more capillary tubes
US5573651A (en) * 1995-04-17 1996-11-12 The Dow Chemical Company Apparatus and method for flow injection analysis
JP3124467B2 (ja) * 1995-04-21 2001-01-15 株式会社精工技研 光カプラ
US5588077A (en) * 1995-05-22 1996-12-24 Focal Technologies, Inc. In-line, two-pass, fiber optic rotary joint
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets

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US6190616B1 (en) 2001-02-20
ATE424552T1 (de) 2009-03-15
ES2321350T3 (es) 2009-06-04
WO1999013312A1 (en) 1999-03-18
EP1019694A1 (de) 2000-07-19
US20010007641A1 (en) 2001-07-12
EP1019694B1 (de) 2009-03-04
JP2001516048A (ja) 2001-09-25
EP1019694A4 (de) 2006-09-13

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