DE69836586D1 - Systeme und verfahren zum gewinnen von mononuklearen zellen durch rezirkulation gepackter roter blutkörper - Google Patents
Systeme und verfahren zum gewinnen von mononuklearen zellen durch rezirkulation gepackter roter blutkörperInfo
- Publication number
- DE69836586D1 DE69836586D1 DE69836586T DE69836586T DE69836586D1 DE 69836586 D1 DE69836586 D1 DE 69836586D1 DE 69836586 T DE69836586 T DE 69836586T DE 69836586 T DE69836586 T DE 69836586T DE 69836586 D1 DE69836586 D1 DE 69836586D1
- Authority
- DE
- Germany
- Prior art keywords
- recirculating
- systems
- mononuclear cells
- reduced rod
- obtaining mononuclear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/302—Active control mechanisms with external energy, e.g. with solenoid valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
- A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36222—Details related to the interface between cassette and machine
- A61M1/362227—Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362261—Constructional details of cassettes, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362265—Details of valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362266—Means for adding solutions or substances to the blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
- B04B2013/006—Interface detection or monitoring of separated components
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US886780 | 1997-07-01 | ||
US08/886,780 US5980760A (en) | 1997-07-01 | 1997-07-01 | System and methods for harvesting mononuclear cells by recirculation of packed red blood cells |
PCT/US1998/012172 WO1999001225A1 (en) | 1997-07-01 | 1998-06-22 | Systems and methods for harvesting mononuclear cells by recirculation of packed red blood cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69836586D1 true DE69836586D1 (de) | 2007-01-18 |
DE69836586T2 DE69836586T2 (de) | 2007-09-13 |
Family
ID=25389755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69836586T Expired - Lifetime DE69836586T2 (de) | 1997-07-01 | 1998-06-22 | Systeme und verfahren zum gewinnen von mononuklearen zellen durch rezirkulation gepackter roter blutkörper |
Country Status (9)
Country | Link |
---|---|
US (1) | US5980760A (de) |
EP (1) | EP1003609B1 (de) |
JP (1) | JP4076588B2 (de) |
CN (1) | CN1113702C (de) |
BR (1) | BR9810649A (de) |
CA (1) | CA2293298A1 (de) |
DE (1) | DE69836586T2 (de) |
ES (1) | ES2278414T3 (de) |
WO (1) | WO1999001225A1 (de) |
Families Citing this family (62)
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US5958250A (en) * | 1995-06-07 | 1999-09-28 | Baxter International Inc. | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
US6312607B1 (en) | 1995-06-07 | 2001-11-06 | Baxter International Inc. | Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent |
US6254784B1 (en) * | 1997-10-30 | 2001-07-03 | Baxter International Inc. | Optical interface detection system for centrifugal blood processing |
JP3196838B2 (ja) * | 1998-09-11 | 2001-08-06 | ヘモネティクス・コーポレーション | アフェレーシス装置及び血液製剤の製造方法 |
US20020077241A1 (en) * | 1999-09-03 | 2002-06-20 | Baxter International Inc. | Blood processing systems and methods with quick attachment of a blood separation chamber to a centrifuge rotor |
US6860846B2 (en) * | 1999-09-03 | 2005-03-01 | Baxter International Inc. | Blood processing systems and methods with umbilicus-driven blood processing chambers |
US6284142B1 (en) * | 1999-09-03 | 2001-09-04 | Baxter International Inc. | Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing |
US6322488B1 (en) | 1999-09-03 | 2001-11-27 | Baxter International Inc. | Blood separation chamber with preformed blood flow passages and centralized connection to external tubing |
US6315707B1 (en) | 1999-09-03 | 2001-11-13 | Baxter International Inc. | Systems and methods for seperating blood in a rotating field |
US6348156B1 (en) | 1999-09-03 | 2002-02-19 | Baxter International Inc. | Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma |
US6294094B1 (en) | 1999-09-03 | 2001-09-25 | Baxter International Inc. | Systems and methods for sensing red blood cell hematocrit |
US6524231B1 (en) | 1999-09-03 | 2003-02-25 | Baxter International Inc. | Blood separation chamber with constricted interior channel and recessed passage |
US7011761B2 (en) * | 1999-09-03 | 2006-03-14 | Baxter International Inc. | Red blood cell processing systems and methods which control red blood cell hematocrit |
US6730054B2 (en) * | 1999-10-16 | 2004-05-04 | Baxter International Inc. | Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit |
US6466879B1 (en) * | 2000-07-13 | 2002-10-15 | Baxter International Inc. | Systems and methods for monitoring introduction of a processing fluid during a fluid processing procedure |
US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
US6884228B2 (en) | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
US6582386B2 (en) | 2001-03-06 | 2003-06-24 | Baxter International Inc. | Multi-purpose, automated blood and fluid processing systems and methods |
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US6878105B2 (en) | 2001-08-16 | 2005-04-12 | Baxter International Inc. | Red blood cell processing systems and methods with deliberate under spill of red blood cells |
JP3997890B2 (ja) * | 2001-11-13 | 2007-10-24 | 松下電器産業株式会社 | 送信方法及び送信装置 |
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US6982038B2 (en) | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
US6849039B2 (en) * | 2002-10-24 | 2005-02-01 | Baxter International Inc. | Blood processing systems and methods for collecting plasma free or essentially free of cellular blood components |
US7297272B2 (en) * | 2002-10-24 | 2007-11-20 | Fenwal, Inc. | Separation apparatus and method |
US8454548B2 (en) | 2008-04-14 | 2013-06-04 | Haemonetics Corporation | System and method for plasma reduced platelet collection |
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US8628489B2 (en) | 2008-04-14 | 2014-01-14 | Haemonetics Corporation | Three-line apheresis system and method |
US8834402B2 (en) | 2009-03-12 | 2014-09-16 | Haemonetics Corporation | System and method for the re-anticoagulation of platelet rich plasma |
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JP5490966B2 (ja) | 2010-11-05 | 2014-05-14 | ヘモネティクス・コーポレーション | 自動化された血小板洗浄のためのシステムおよび方法 |
US8870733B2 (en) | 2010-11-19 | 2014-10-28 | Kensey Nash Corporation | Centrifuge |
US8469871B2 (en) | 2010-11-19 | 2013-06-25 | Kensey Nash Corporation | Centrifuge |
US8556794B2 (en) | 2010-11-19 | 2013-10-15 | Kensey Nash Corporation | Centrifuge |
US8394006B2 (en) | 2010-11-19 | 2013-03-12 | Kensey Nash Corporation | Centrifuge |
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US9302042B2 (en) | 2010-12-30 | 2016-04-05 | Haemonetics Corporation | System and method for collecting platelets and anticipating plasma return |
US11386993B2 (en) | 2011-05-18 | 2022-07-12 | Fenwal, Inc. | Plasma collection with remote programming |
EP2731724B1 (de) * | 2011-09-22 | 2015-01-14 | Fenwal, Inc. | Antriebssystem für eine zentrifuge |
JP6250053B2 (ja) | 2012-09-04 | 2017-12-20 | フェンウォール、インコーポレイテッド | 血液処理システムの境界検知装置 |
KR102369602B1 (ko) | 2014-01-31 | 2022-03-02 | 디에스엠 아이피 어셋츠 비.브이. | 지방 조직 원심 분리기 및 그 사용 방법 |
US9833557B2 (en) | 2014-12-19 | 2017-12-05 | Fenwal, Inc. | Systems and methods for determining free plasma hemoglobin |
US10556053B2 (en) | 2017-01-30 | 2020-02-11 | Fenwal, Inc. | System for collecting mononuclear cells having a suitable hematocrit for extracorporeal photopheresis |
CN106890373A (zh) * | 2017-02-10 | 2017-06-27 | 广州上诺生物技术有限公司 | 一种用于数字化管理血浆过滤白细胞的方法及系统 |
US11285250B2 (en) * | 2017-03-07 | 2022-03-29 | Fenwal, Inc. | Systems and methods for separating blood under conditions of reduced plasma clarity |
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EP3501562A1 (de) | 2017-12-22 | 2019-06-26 | Fenwal, Inc. | Verarbeitungsanordnungen für umwandelbares fluid |
WO2019140491A1 (en) | 2018-01-22 | 2019-07-25 | Scinogy Products Pty Ltd | System, method and controller for recovery of concentrated particles suspended in fluid |
EP3553498B1 (de) | 2018-04-13 | 2021-06-02 | Fenwal, Inc. | Optische erfassung und messung von hämatokrit und freier hämoglobinkonzentration |
JP6976458B2 (ja) | 2018-05-21 | 2021-12-08 | フェンウォール、インコーポレイテッド | 血漿収集量を最適化するためのシステムおよび方法 |
US11412967B2 (en) | 2018-05-21 | 2022-08-16 | Fenwal, Inc. | Systems and methods for plasma collection |
EP3578971B1 (de) | 2018-06-05 | 2021-12-15 | Fenwal, Inc. | Bestimmung der ursache von rötung in einer biologischen flüssigkeit |
US11137344B2 (en) | 2018-11-28 | 2021-10-05 | Fenwal, Inc. | Optical mixing of fluids |
EP3705146A3 (de) | 2019-03-05 | 2020-11-25 | Fenwal, Inc. | Entnahme von mononukleären zellen und peripheren blutstammzellen |
US20200282116A1 (en) | 2019-03-05 | 2020-09-10 | Fenwal, Inc. | Collection, Genome Editing, And Washing Of T-Cell Lymphocytes |
EP4238595A3 (de) | 2019-05-23 | 2023-11-29 | Fenwal, Inc. | Einstellung der zielgrenzflächenposition zwischen getrennten fluidkomponenten in einer zentrifuge |
US11898967B2 (en) | 2021-02-02 | 2024-02-13 | Fenwal, Inc. | Predicting malfunction and failure of centrifuge umbilicus |
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-
1997
- 1997-07-01 US US08/886,780 patent/US5980760A/en not_active Expired - Lifetime
-
1998
- 1998-06-22 ES ES98934139T patent/ES2278414T3/es not_active Expired - Lifetime
- 1998-06-22 DE DE69836586T patent/DE69836586T2/de not_active Expired - Lifetime
- 1998-06-22 EP EP98934139A patent/EP1003609B1/de not_active Expired - Lifetime
- 1998-06-22 JP JP50866599A patent/JP4076588B2/ja not_active Expired - Fee Related
- 1998-06-22 CN CN98806828A patent/CN1113702C/zh not_active Expired - Fee Related
- 1998-06-22 WO PCT/US1998/012172 patent/WO1999001225A1/en active IP Right Grant
- 1998-06-22 CA CA002293298A patent/CA2293298A1/en not_active Abandoned
- 1998-06-22 BR BR9810649-0A patent/BR9810649A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP4076588B2 (ja) | 2008-04-16 |
CN1268075A (zh) | 2000-09-27 |
EP1003609A4 (de) | 2004-12-15 |
BR9810649A (pt) | 2000-10-03 |
CA2293298A1 (en) | 1999-01-14 |
CN1113702C (zh) | 2003-07-09 |
EP1003609B1 (de) | 2006-12-06 |
US5980760A (en) | 1999-11-09 |
WO1999001225A1 (en) | 1999-01-14 |
ES2278414T3 (es) | 2007-08-01 |
DE69836586T2 (de) | 2007-09-13 |
JP2002511785A (ja) | 2002-04-16 |
EP1003609A1 (de) | 2000-05-31 |
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