DE69835854D1 - Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der Druchflusszytometrie - Google Patents
Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der DruchflusszytometrieInfo
- Publication number
- DE69835854D1 DE69835854D1 DE69835854T DE69835854T DE69835854D1 DE 69835854 D1 DE69835854 D1 DE 69835854D1 DE 69835854 T DE69835854 T DE 69835854T DE 69835854 T DE69835854 T DE 69835854T DE 69835854 D1 DE69835854 D1 DE 69835854D1
- Authority
- DE
- Germany
- Prior art keywords
- instruments
- polymer particles
- particles
- calibration
- flow cytometry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title abstract 9
- 238000000684 flow cytometry Methods 0.000 title abstract 2
- 229920001059 synthetic polymer Polymers 0.000 title abstract 2
- 239000011324 bead Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 210000001995 reticulocyte Anatomy 0.000 abstract 1
- 238000011425 standardization method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
-
- G01N15/149—
-
- G01N2015/1024—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1486—Counting the particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5047797P | 1997-06-23 | 1997-06-23 | |
US50477P | 1997-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69835854D1 true DE69835854D1 (de) | 2006-10-26 |
DE69835854T2 DE69835854T2 (de) | 2007-03-08 |
Family
ID=21965468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69835854T Expired - Lifetime DE69835854T2 (de) | 1997-06-23 | 1998-06-23 | Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der Druchflusszytometrie |
Country Status (6)
Country | Link |
---|---|
US (2) | US6074879A (de) |
EP (1) | EP0887637B1 (de) |
JP (1) | JPH1183724A (de) |
AT (1) | ATE339681T1 (de) |
DE (1) | DE69835854T2 (de) |
ES (1) | ES2273384T3 (de) |
Families Citing this family (76)
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US6905881B2 (en) * | 2000-11-30 | 2005-06-14 | Paul Sammak | Microbead-based test plates and test methods for fluorescence imaging systems |
JP2002251091A (ja) * | 2001-02-27 | 2002-09-06 | Konica Corp | 画像定着装置および画像形成装置 |
US6723563B2 (en) | 2001-12-03 | 2004-04-20 | Streck Laboratories Inc. | Hematology reference control |
US6653137B2 (en) | 2001-12-03 | 2003-11-25 | Streck Laboratories Inc. | Hematology reference control |
KR101166180B1 (ko) * | 2003-08-13 | 2012-07-18 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법 |
US6962817B2 (en) * | 2003-10-02 | 2005-11-08 | Beckman Coulter, Inc. | Reference control for optical measurement of nucleated red blood cells of a blood sample |
US7195919B2 (en) * | 2003-12-19 | 2007-03-27 | Beckman Coulter, Inc. | Hematology controls for reticulocytes and nucleated red blood cells |
US7081227B2 (en) * | 2004-06-07 | 2006-07-25 | The Reagents Of The University Of California | Amphiphilic mediated sample preparation for micro-flow cytometry |
US7340957B2 (en) | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
US20060045814A1 (en) * | 2004-09-01 | 2006-03-02 | Zhang Yu-Zhong | Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use |
WO2006029017A1 (en) * | 2004-09-03 | 2006-03-16 | Symyx Technologies, Inc. | System and method for rapid chromatography with fluid temperature and mobile phase composition control |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US7531357B2 (en) * | 2005-04-04 | 2009-05-12 | Bio-Rad Laboratories, Inc. | Preparation of platelet analogs |
ITUD20050118A1 (it) | 2005-07-13 | 2007-01-14 | Sire Analytical Systems Srl | Procedimento per la taratura di macchine per l' analisi di parametri del sangue connessi alla densita' del sangue, quali la velocita' di eritrosedimentazione e/o di aggregazione dei globuli rossi |
WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
CN100386054C (zh) * | 2006-04-24 | 2008-05-07 | 西安交通大学 | 用于脉搏血氧仿真器的光散射介质及制备方法 |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US9074242B2 (en) | 2010-02-12 | 2015-07-07 | Raindance Technologies, Inc. | Digital analyte analysis |
EP2530168B1 (de) | 2006-05-11 | 2015-09-16 | Raindance Technologies, Inc. | Mikrofluidische Vorrichtungen |
US7835000B2 (en) | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
EP2479552B1 (de) * | 2007-04-02 | 2015-09-02 | Acoustic Cytometry Systems, Inc. | Verfahren zur verbesserten Analyse von in einem akustischen Feld fokussierten Zellen und Partikeln |
US8083068B2 (en) | 2007-04-09 | 2011-12-27 | Los Alamos National Security, Llc | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
US7837040B2 (en) * | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US7859664B2 (en) * | 2007-09-13 | 2010-12-28 | Brightwell Technologies Inc. | Plurality of samples and method for selecting a target sample therefrom |
US8102528B2 (en) * | 2007-09-13 | 2012-01-24 | Brightwell Technologies Inc. | Particle standard and method of calibrating or validating an optical particle analyzer |
US8263407B2 (en) | 2007-10-24 | 2012-09-11 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8528406B2 (en) * | 2007-10-24 | 2013-09-10 | Los Alamos National Security, LLP | Method for non-contact particle manipulation and control of particle spacing along an axis |
JP2009115672A (ja) * | 2007-11-08 | 2009-05-28 | Sony Corp | 微小粒子の光学的測定方法及び分取方法、並びに前記光学的測定方法及び分取方法に用いる流路、光学的測定装置及びフローサイトメータ |
US8266950B2 (en) | 2007-12-19 | 2012-09-18 | Los Alamos National Security, LLP | Particle analysis in an acoustic cytometer |
US8714014B2 (en) | 2008-01-16 | 2014-05-06 | Life Technologies Corporation | System and method for acoustic focusing hardware and implementations |
EP4047367A1 (de) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken |
US8187885B2 (en) * | 2009-05-07 | 2012-05-29 | Nodality, Inc. | Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument |
WO2010135627A1 (en) | 2009-05-21 | 2010-11-25 | Intellicyt | System and method for separating samples in a continuous flow |
JP5304456B2 (ja) | 2009-06-10 | 2013-10-02 | ソニー株式会社 | 微小粒子測定装置 |
US20110134426A1 (en) * | 2009-12-04 | 2011-06-09 | Life Technologies Corporation | Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry. |
FR2956207B1 (fr) | 2010-02-10 | 2012-05-04 | Horiba Abx Sas | Dispositif et procede de mesures multiparametriques de microparticules dans un fluide |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
JP2012047464A (ja) | 2010-08-24 | 2012-03-08 | Sony Corp | 微小粒子測定装置及び光軸補正方法 |
WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9522396B2 (en) | 2010-12-29 | 2016-12-20 | S.D. Sight Diagnostics Ltd. | Apparatus and method for automatic detection of pathogens |
EP3412778A1 (de) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Verfahren zur bildung gemischter tröpfchen |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
WO2012167142A2 (en) | 2011-06-02 | 2012-12-06 | Raindance Technolgies, Inc. | Enzyme quantification |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
GB2499796B (en) * | 2012-02-28 | 2016-06-15 | Ojk Consulting Ltd | Method and system for calibrating a flow cytometer |
WO2013159296A1 (zh) * | 2012-04-25 | 2013-10-31 | 深圳联合医学科技有限公司 | 用于对血球试剂进行标记或对测试过程进行控制的方法 |
EP2999988A4 (de) | 2013-05-23 | 2017-01-11 | S.D. Sight Diagnostics Ltd. | Verfahren und system zur bildgebung einer zellprobe |
IL227276A0 (en) | 2013-07-01 | 2014-03-06 | Parasight Ltd | A method and system for obtaining a monolayer of cells, for use specifically for diagnosis |
US9562846B2 (en) * | 2013-07-10 | 2017-02-07 | Kla-Tencor Corporation | Particle suspensions used as low-contrast standards for inspection of liquids |
EP3039477B1 (de) | 2013-08-26 | 2021-10-20 | S.D. Sight Diagnostics Ltd. | Digitale mikroskopiesysteme, verfahren und computerprogrammprodukte |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
WO2016030897A1 (en) | 2014-08-27 | 2016-03-03 | S.D. Sight Diagnostics Ltd | System and method for calculating focus variation for a digital microscope |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
CA2998829A1 (en) | 2015-09-17 | 2017-03-23 | S.D. Sight Diagnostics Ltd | Methods and apparatus for detecting an entity in a bodily sample |
JP6237806B2 (ja) * | 2016-03-16 | 2017-11-29 | ソニー株式会社 | 微小粒子分取装置 |
US11733150B2 (en) | 2016-03-30 | 2023-08-22 | S.D. Sight Diagnostics Ltd. | Distinguishing between blood sample components |
CA3022770A1 (en) | 2016-05-11 | 2017-11-16 | S.D. Sight Diagnostics Ltd | Performing optical measurements on a sample |
US11307196B2 (en) | 2016-05-11 | 2022-04-19 | S.D. Sight Diagnostics Ltd. | Sample carrier for optical measurements |
CA3094373C (en) | 2018-03-30 | 2023-10-17 | Idexx Laboratories, Inc. | Flow cytometer, laser optics assembly thereof, and methods of assembling the same |
BR112020016080A2 (pt) * | 2018-03-30 | 2020-12-15 | Idexx Laboratories, Inc. | Sistema de diagnóstico médico no ponto de atendimento. |
WO2019207988A1 (ja) | 2018-04-25 | 2019-10-31 | ソニー株式会社 | 微小粒子分取装置及び微小粒子分取方法 |
CN108827860A (zh) * | 2018-06-22 | 2018-11-16 | 沧州医学高等专科学校 | 一种用改良Neubauer计数板进行网织红细胞计数的方法 |
CN113474302A (zh) * | 2019-02-18 | 2021-10-01 | 凯米拉公司 | 监测和任选地控制从包含微塑料的水中去除微塑料的方法 |
CN115087393A (zh) * | 2019-12-19 | 2022-09-20 | 罗氏血液诊断股份有限公司 | 用于校准和质量控制的组合物和方法 |
JP7446008B2 (ja) * | 2020-03-31 | 2024-03-08 | 国立研究開発法人産業技術総合研究所 | 粒子の屈折率計測方法 |
EP4168773A1 (de) | 2020-06-17 | 2023-04-26 | Idexx Laboratories, Inc. | Durchflusszytometer und laseroptikanordnung dafür |
Family Cites Families (20)
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US4331862A (en) * | 1979-02-23 | 1982-05-25 | Ryan Wayne L | Method for calibrating a particle counting machine and a calibration standard therefor |
US4489162A (en) * | 1981-12-21 | 1984-12-18 | American Hospital Supply Corporation | Fresh blood (unfixed) hematology control |
US4735504A (en) * | 1983-10-31 | 1988-04-05 | Technicon Instruments Corporation | Method and apparatus for determining the volume & index of refraction of particles |
JPH0617373B2 (ja) * | 1984-07-06 | 1994-03-09 | 株式会社リコー | 粒子径分布の狭い重合体粒子の製造法 |
US5093234A (en) * | 1984-12-24 | 1992-03-03 | Caribbean Microparticles Corporation | Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor |
US4857451A (en) * | 1984-12-24 | 1989-08-15 | Flow Cytometry Standards Corporation | Method of compensating and calibrating a flow cytometer, and microbead standards kit therefor |
US4767206A (en) * | 1984-12-24 | 1988-08-30 | Flow Cytometry Standards Corporation | Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof |
US5073497A (en) * | 1989-06-30 | 1991-12-17 | Caribbean Microparticles Corporation | Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads |
US5084394A (en) * | 1984-12-24 | 1992-01-28 | Vogt Robert F | Method for corrective calibration of a flow cytometry using a mixture of fluorescent microbeads and cells |
US5380663A (en) * | 1984-12-24 | 1995-01-10 | Caribbean Microparticles Corporation | Automated system for performance analysis and fluorescence quantitation of samples |
US4868126A (en) * | 1985-12-11 | 1989-09-19 | Flow Cytometry Standards Corporation | Method of calibrating a fluorescent microscope using fluorescent calibration microbeads simulating stained cells |
US4704891A (en) * | 1986-08-29 | 1987-11-10 | Becton, Dickinson And Company | Method and materials for calibrating flow cytometers and other analysis instruments |
US4867908A (en) * | 1986-08-29 | 1989-09-19 | Becton, Dickinson And Company | Method and materials for calibrating flow cytometers and other analysis instruments |
DE3708032A1 (de) * | 1987-03-12 | 1988-09-22 | Agfa Gevaert Ag | Fluorhaltige perlpolymerisate |
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GB8911859D0 (en) * | 1989-05-23 | 1989-07-12 | Ilford Ltd | Polymer particles |
EP0483416B1 (de) * | 1990-11-02 | 1995-03-22 | Agfa-Gevaert N.V. | Verfahren zur Herstellung wässriger beladener Latexzusammensetzungen |
JP3328032B2 (ja) * | 1993-11-04 | 2002-09-24 | シスメックス株式会社 | 粒子分析装置 |
US5540494A (en) * | 1994-06-03 | 1996-07-30 | Purvis, Jr.; Norman B. | Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry |
US5837547A (en) * | 1995-12-27 | 1998-11-17 | Caribbean Microparticles Corporation | Flow cytometer calibration method |
-
1998
- 1998-06-17 US US09/099,233 patent/US6074879A/en not_active Expired - Lifetime
- 1998-06-23 AT AT98111504T patent/ATE339681T1/de not_active IP Right Cessation
- 1998-06-23 EP EP98111504A patent/EP0887637B1/de not_active Expired - Lifetime
- 1998-06-23 DE DE69835854T patent/DE69835854T2/de not_active Expired - Lifetime
- 1998-06-23 ES ES98111504T patent/ES2273384T3/es not_active Expired - Lifetime
- 1998-06-23 JP JP10192381A patent/JPH1183724A/ja active Pending
-
1999
- 1999-11-02 US US09/432,905 patent/US6521729B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0887637A2 (de) | 1998-12-30 |
ES2273384T3 (es) | 2007-05-01 |
JPH1183724A (ja) | 1999-03-26 |
DE69835854T2 (de) | 2007-03-08 |
EP0887637A3 (de) | 1999-12-22 |
ATE339681T1 (de) | 2006-10-15 |
US6521729B1 (en) | 2003-02-18 |
EP0887637B1 (de) | 2006-09-13 |
US6074879A (en) | 2000-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN |