DE69835854D1 - Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der Druchflusszytometrie - Google Patents

Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der Druchflusszytometrie

Info

Publication number
DE69835854D1
DE69835854D1 DE69835854T DE69835854T DE69835854D1 DE 69835854 D1 DE69835854 D1 DE 69835854D1 DE 69835854 T DE69835854 T DE 69835854T DE 69835854 T DE69835854 T DE 69835854T DE 69835854 D1 DE69835854 D1 DE 69835854D1
Authority
DE
Germany
Prior art keywords
instruments
polymer particles
particles
calibration
flow cytometry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69835854T
Other languages
English (en)
Other versions
DE69835854T2 (de
Inventor
David Zelmanovic
William Moskalski
Ronny Declercq
Frank Louwet
Eberhard Dr Kuckert
Wolfgang Dr Podszun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of DE69835854D1 publication Critical patent/DE69835854D1/de
Application granted granted Critical
Publication of DE69835854T2 publication Critical patent/DE69835854T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1012Calibrating particle analysers; References therefor
    • G01N15/149
    • G01N2015/1024
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1486Counting the particles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666Particle count or volume standard or control [e.g., platelet count standards, etc.]
DE69835854T 1997-06-23 1998-06-23 Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der Druchflusszytometrie Expired - Lifetime DE69835854T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5047797P 1997-06-23 1997-06-23
US50477P 1997-06-23

Publications (2)

Publication Number Publication Date
DE69835854D1 true DE69835854D1 (de) 2006-10-26
DE69835854T2 DE69835854T2 (de) 2007-03-08

Family

ID=21965468

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69835854T Expired - Lifetime DE69835854T2 (de) 1997-06-23 1998-06-23 Verwendung synthetischer Polymerteilchen als Standards und Kalibratoren in der Druchflusszytometrie

Country Status (6)

Country Link
US (2) US6074879A (de)
EP (1) EP0887637B1 (de)
JP (1) JPH1183724A (de)
AT (1) ATE339681T1 (de)
DE (1) DE69835854T2 (de)
ES (1) ES2273384T3 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294388B1 (en) * 1998-04-03 2001-09-25 Symyx Technologies, Inc. Indirect calibration of polymer characterization systems
US6200500B1 (en) * 1999-08-20 2001-03-13 Streck Laboratories, Inc. Hematology control and system for multi-parameter hematology measurements
JP4606543B2 (ja) * 2000-04-13 2011-01-05 パナソニック株式会社 光学特性計測装置における被検溶液量確認方法および計測系制御方法
US6784981B1 (en) * 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
US6572922B1 (en) * 2000-07-25 2003-06-03 Seagate Technology Llc Eliminating gel particle-related defects for obtaining sub-micron flyability over sol-gel—coated disk substrates
US6905881B2 (en) * 2000-11-30 2005-06-14 Paul Sammak Microbead-based test plates and test methods for fluorescence imaging systems
JP2002251091A (ja) * 2001-02-27 2002-09-06 Konica Corp 画像定着装置および画像形成装置
US6723563B2 (en) 2001-12-03 2004-04-20 Streck Laboratories Inc. Hematology reference control
US6653137B2 (en) 2001-12-03 2003-11-25 Streck Laboratories Inc. Hematology reference control
KR101166180B1 (ko) * 2003-08-13 2012-07-18 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
US6962817B2 (en) * 2003-10-02 2005-11-08 Beckman Coulter, Inc. Reference control for optical measurement of nucleated red blood cells of a blood sample
US7195919B2 (en) * 2003-12-19 2007-03-27 Beckman Coulter, Inc. Hematology controls for reticulocytes and nucleated red blood cells
US7081227B2 (en) * 2004-06-07 2006-07-25 The Reagents Of The University Of California Amphiphilic mediated sample preparation for micro-flow cytometry
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US20060045814A1 (en) * 2004-09-01 2006-03-02 Zhang Yu-Zhong Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use
WO2006029017A1 (en) * 2004-09-03 2006-03-16 Symyx Technologies, Inc. System and method for rapid chromatography with fluid temperature and mobile phase composition control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7531357B2 (en) * 2005-04-04 2009-05-12 Bio-Rad Laboratories, Inc. Preparation of platelet analogs
ITUD20050118A1 (it) 2005-07-13 2007-01-14 Sire Analytical Systems Srl Procedimento per la taratura di macchine per l' analisi di parametri del sangue connessi alla densita' del sangue, quali la velocita' di eritrosedimentazione e/o di aggregazione dei globuli rossi
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
CN100386054C (zh) * 2006-04-24 2008-05-07 西安交通大学 用于脉搏血氧仿真器的光散射介质及制备方法
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2530168B1 (de) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP2479552B1 (de) * 2007-04-02 2015-09-02 Acoustic Cytometry Systems, Inc. Verfahren zur verbesserten Analyse von in einem akustischen Feld fokussierten Zellen und Partikeln
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US7859664B2 (en) * 2007-09-13 2010-12-28 Brightwell Technologies Inc. Plurality of samples and method for selecting a target sample therefrom
US8102528B2 (en) * 2007-09-13 2012-01-24 Brightwell Technologies Inc. Particle standard and method of calibrating or validating an optical particle analyzer
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) * 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
JP2009115672A (ja) * 2007-11-08 2009-05-28 Sony Corp 微小粒子の光学的測定方法及び分取方法、並びに前記光学的測定方法及び分取方法に用いる流路、光学的測定装置及びフローサイトメータ
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US8187885B2 (en) * 2009-05-07 2012-05-29 Nodality, Inc. Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument
WO2010135627A1 (en) 2009-05-21 2010-11-25 Intellicyt System and method for separating samples in a continuous flow
JP5304456B2 (ja) 2009-06-10 2013-10-02 ソニー株式会社 微小粒子測定装置
US20110134426A1 (en) * 2009-12-04 2011-06-09 Life Technologies Corporation Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry.
FR2956207B1 (fr) 2010-02-10 2012-05-04 Horiba Abx Sas Dispositif et procede de mesures multiparametriques de microparticules dans un fluide
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP2012047464A (ja) 2010-08-24 2012-03-08 Sony Corp 微小粒子測定装置及び光軸補正方法
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
GB2499796B (en) * 2012-02-28 2016-06-15 Ojk Consulting Ltd Method and system for calibrating a flow cytometer
WO2013159296A1 (zh) * 2012-04-25 2013-10-31 深圳联合医学科技有限公司 用于对血球试剂进行标记或对测试过程进行控制的方法
EP2999988A4 (de) 2013-05-23 2017-01-11 S.D. Sight Diagnostics Ltd. Verfahren und system zur bildgebung einer zellprobe
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for obtaining a monolayer of cells, for use specifically for diagnosis
US9562846B2 (en) * 2013-07-10 2017-02-07 Kla-Tencor Corporation Particle suspensions used as low-contrast standards for inspection of liquids
EP3039477B1 (de) 2013-08-26 2021-10-20 S.D. Sight Diagnostics Ltd. Digitale mikroskopiesysteme, verfahren und computerprogrammprodukte
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2016030897A1 (en) 2014-08-27 2016-03-03 S.D. Sight Diagnostics Ltd System and method for calculating focus variation for a digital microscope
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CA2998829A1 (en) 2015-09-17 2017-03-23 S.D. Sight Diagnostics Ltd Methods and apparatus for detecting an entity in a bodily sample
JP6237806B2 (ja) * 2016-03-16 2017-11-29 ソニー株式会社 微小粒子分取装置
US11733150B2 (en) 2016-03-30 2023-08-22 S.D. Sight Diagnostics Ltd. Distinguishing between blood sample components
CA3022770A1 (en) 2016-05-11 2017-11-16 S.D. Sight Diagnostics Ltd Performing optical measurements on a sample
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
CA3094373C (en) 2018-03-30 2023-10-17 Idexx Laboratories, Inc. Flow cytometer, laser optics assembly thereof, and methods of assembling the same
BR112020016080A2 (pt) * 2018-03-30 2020-12-15 Idexx Laboratories, Inc. Sistema de diagnóstico médico no ponto de atendimento.
WO2019207988A1 (ja) 2018-04-25 2019-10-31 ソニー株式会社 微小粒子分取装置及び微小粒子分取方法
CN108827860A (zh) * 2018-06-22 2018-11-16 沧州医学高等专科学校 一种用改良Neubauer计数板进行网织红细胞计数的方法
CN113474302A (zh) * 2019-02-18 2021-10-01 凯米拉公司 监测和任选地控制从包含微塑料的水中去除微塑料的方法
CN115087393A (zh) * 2019-12-19 2022-09-20 罗氏血液诊断股份有限公司 用于校准和质量控制的组合物和方法
JP7446008B2 (ja) * 2020-03-31 2024-03-08 国立研究開発法人産業技術総合研究所 粒子の屈折率計測方法
EP4168773A1 (de) 2020-06-17 2023-04-26 Idexx Laboratories, Inc. Durchflusszytometer und laseroptikanordnung dafür

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331862A (en) * 1979-02-23 1982-05-25 Ryan Wayne L Method for calibrating a particle counting machine and a calibration standard therefor
US4489162A (en) * 1981-12-21 1984-12-18 American Hospital Supply Corporation Fresh blood (unfixed) hematology control
US4735504A (en) * 1983-10-31 1988-04-05 Technicon Instruments Corporation Method and apparatus for determining the volume & index of refraction of particles
JPH0617373B2 (ja) * 1984-07-06 1994-03-09 株式会社リコー 粒子径分布の狭い重合体粒子の製造法
US5093234A (en) * 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
US4857451A (en) * 1984-12-24 1989-08-15 Flow Cytometry Standards Corporation Method of compensating and calibrating a flow cytometer, and microbead standards kit therefor
US4767206A (en) * 1984-12-24 1988-08-30 Flow Cytometry Standards Corporation Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
US5073497A (en) * 1989-06-30 1991-12-17 Caribbean Microparticles Corporation Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads
US5084394A (en) * 1984-12-24 1992-01-28 Vogt Robert F Method for corrective calibration of a flow cytometry using a mixture of fluorescent microbeads and cells
US5380663A (en) * 1984-12-24 1995-01-10 Caribbean Microparticles Corporation Automated system for performance analysis and fluorescence quantitation of samples
US4868126A (en) * 1985-12-11 1989-09-19 Flow Cytometry Standards Corporation Method of calibrating a fluorescent microscope using fluorescent calibration microbeads simulating stained cells
US4704891A (en) * 1986-08-29 1987-11-10 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
US4867908A (en) * 1986-08-29 1989-09-19 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
DE3708032A1 (de) * 1987-03-12 1988-09-22 Agfa Gevaert Ag Fluorhaltige perlpolymerisate
US4777139A (en) * 1987-06-25 1988-10-11 Fisher Scientific Company Hematology control or calibrator with red cell components of enhanced stability
GB8911859D0 (en) * 1989-05-23 1989-07-12 Ilford Ltd Polymer particles
EP0483416B1 (de) * 1990-11-02 1995-03-22 Agfa-Gevaert N.V. Verfahren zur Herstellung wässriger beladener Latexzusammensetzungen
JP3328032B2 (ja) * 1993-11-04 2002-09-24 シスメックス株式会社 粒子分析装置
US5540494A (en) * 1994-06-03 1996-07-30 Purvis, Jr.; Norman B. Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry
US5837547A (en) * 1995-12-27 1998-11-17 Caribbean Microparticles Corporation Flow cytometer calibration method

Also Published As

Publication number Publication date
EP0887637A2 (de) 1998-12-30
ES2273384T3 (es) 2007-05-01
JPH1183724A (ja) 1999-03-26
DE69835854T2 (de) 2007-03-08
EP0887637A3 (de) 1999-12-22
ATE339681T1 (de) 2006-10-15
US6521729B1 (en) 2003-02-18
EP0887637B1 (de) 2006-09-13
US6074879A (en) 2000-06-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US

8328 Change in the person/name/address of the agent

Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN