DE69835241D1 - 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen - Google Patents

4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen

Info

Publication number
DE69835241D1
DE69835241D1 DE69835241T DE69835241T DE69835241D1 DE 69835241 D1 DE69835241 D1 DE 69835241D1 DE 69835241 T DE69835241 T DE 69835241T DE 69835241 T DE69835241 T DE 69835241T DE 69835241 D1 DE69835241 D1 DE 69835241D1
Authority
DE
Germany
Prior art keywords
cyclin
inhibitors
preparation
dependent kinases
aminothiazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69835241T
Other languages
English (en)
Other versions
DE69835241T2 (de
Inventor
Wesley K M Chong
Shao Song Chu
Rohit R Duvadie
Lin Li
Wei Xiao
Yi Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Publication of DE69835241D1 publication Critical patent/DE69835241D1/de
Application granted granted Critical
Publication of DE69835241T2 publication Critical patent/DE69835241T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
DE69835241T 1997-10-27 1998-10-27 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen Expired - Fee Related DE69835241T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6363497P 1997-10-27 1997-10-27
US63634P 1997-10-27
US6366697P 1997-10-28 1997-10-28
US63666P 1997-10-28

Publications (2)

Publication Number Publication Date
DE69835241D1 true DE69835241D1 (de) 2006-08-24
DE69835241T2 DE69835241T2 (de) 2007-05-31

Family

ID=26743609

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69835241T Expired - Fee Related DE69835241T2 (de) 1997-10-27 1998-10-27 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen
DE69833223T Expired - Fee Related DE69833223T2 (de) 1997-10-27 1998-10-27 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69833223T Expired - Fee Related DE69833223T2 (de) 1997-10-27 1998-10-27 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasen

Country Status (34)

Country Link
US (2) US6569878B1 (de)
EP (1) EP1056732B1 (de)
JP (1) JP2004500304A (de)
KR (1) KR20010082501A (de)
CN (1) CN1158269C (de)
AP (1) AP1445A (de)
AT (2) ATE315553T1 (de)
AU (1) AU738792B2 (de)
BG (1) BG64195B1 (de)
BR (1) BR9815200A (de)
CA (1) CA2306082A1 (de)
DE (2) DE69835241T2 (de)
EA (1) EA003527B1 (de)
EE (1) EE200000289A (de)
ES (2) ES2267873T3 (de)
GE (1) GEP20032896B (de)
HR (1) HRP20000222A2 (de)
HU (1) HUP0004512A3 (de)
ID (1) ID24372A (de)
IL (1) IL135574A0 (de)
IS (1) IS5462A (de)
LT (1) LT4855B (de)
LV (1) LV12592B (de)
NO (1) NO20001955L (de)
NZ (1) NZ503788A (de)
OA (1) OA11352A (de)
PL (1) PL342447A1 (de)
RO (1) RO119463B1 (de)
SI (1) SI20324A (de)
SK (1) SK5212000A3 (de)
TR (1) TR200001081T2 (de)
UA (1) UA66810C2 (de)
WO (1) WO1999021845A2 (de)
YU (1) YU22400A (de)

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NO20001955L (no) 2000-06-16
US6569878B1 (en) 2003-05-27
EE200000289A (et) 2001-06-15
BG104478A (en) 2001-02-28
DE69833223D1 (de) 2006-04-06
HRP20000222A2 (en) 2001-02-28
HUP0004512A2 (hu) 2002-03-28
OA11352A (en) 2003-12-23
KR20010082501A (ko) 2001-08-30
AP1445A (en) 2005-07-10
AU1366499A (en) 1999-05-17
NZ503788A (en) 2002-11-26
WO1999021845A2 (en) 1999-05-06
CN1276789A (zh) 2000-12-13
NO20001955D0 (no) 2000-04-14
EA003527B1 (ru) 2003-06-26
LV12592A (en) 2000-12-20
LV12592B (en) 2001-07-20
RO119463B1 (ro) 2004-11-30
BR9815200A (pt) 2001-10-16
EP1056732B1 (de) 2006-01-11
DE69835241T2 (de) 2007-05-31
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