DE69833223D1 - 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasen - Google Patents
4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasenInfo
- Publication number
- DE69833223D1 DE69833223D1 DE69833223T DE69833223T DE69833223D1 DE 69833223 D1 DE69833223 D1 DE 69833223D1 DE 69833223 T DE69833223 T DE 69833223T DE 69833223 T DE69833223 T DE 69833223T DE 69833223 D1 DE69833223 D1 DE 69833223D1
- Authority
- DE
- Germany
- Prior art keywords
- aminothiazol
- derivatives
- preparation
- dependent kinases
- cyclin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6363497P | 1997-10-27 | 1997-10-27 | |
US63634P | 1997-10-27 | ||
US6366697P | 1997-10-28 | 1997-10-28 | |
US63666P | 1997-10-28 | ||
PCT/US1998/022809 WO1999021845A2 (en) | 1997-10-27 | 1998-10-27 | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69833223D1 true DE69833223D1 (de) | 2006-04-06 |
DE69833223T2 DE69833223T2 (de) | 2006-09-14 |
Family
ID=26743609
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69835241T Expired - Fee Related DE69835241T2 (de) | 1997-10-27 | 1998-10-27 | 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen |
DE69833223T Expired - Fee Related DE69833223T2 (de) | 1997-10-27 | 1998-10-27 | 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69835241T Expired - Fee Related DE69835241T2 (de) | 1997-10-27 | 1998-10-27 | 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen |
Country Status (34)
Country | Link |
---|---|
US (2) | US6569878B1 (de) |
EP (1) | EP1056732B1 (de) |
JP (1) | JP2004500304A (de) |
KR (1) | KR20010082501A (de) |
CN (1) | CN1158269C (de) |
AP (1) | AP1445A (de) |
AT (2) | ATE332896T1 (de) |
AU (1) | AU738792B2 (de) |
BG (1) | BG64195B1 (de) |
BR (1) | BR9815200A (de) |
CA (1) | CA2306082A1 (de) |
DE (2) | DE69835241T2 (de) |
EA (1) | EA003527B1 (de) |
EE (1) | EE200000289A (de) |
ES (2) | ES2267873T3 (de) |
GE (1) | GEP20032896B (de) |
HR (1) | HRP20000222A2 (de) |
HU (1) | HUP0004512A3 (de) |
ID (1) | ID24372A (de) |
IL (1) | IL135574A0 (de) |
IS (1) | IS5462A (de) |
LT (1) | LT4855B (de) |
LV (1) | LV12592B (de) |
NO (1) | NO20001955L (de) |
NZ (1) | NZ503788A (de) |
OA (1) | OA11352A (de) |
PL (1) | PL342447A1 (de) |
RO (1) | RO119463B1 (de) |
SI (1) | SI20324A (de) |
SK (1) | SK5212000A3 (de) |
TR (1) | TR200001081T2 (de) |
UA (1) | UA66810C2 (de) |
WO (1) | WO1999021845A2 (de) |
YU (1) | YU22400A (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69835241T2 (de) * | 1997-10-27 | 2007-05-31 | Agouron Pharmaceuticals, Inc., La Jolla | 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen |
UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
PL346795A1 (en) * | 1998-09-22 | 2002-02-25 | Yamanouchi Pharma Co Ltd | Cyanophenyl derivatives |
US6414156B2 (en) | 1998-10-21 | 2002-07-02 | Bristol-Myers Squibb Company | Process for preparing azacycloalkanoylaminothiazoles |
US6214852B1 (en) | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
KR100722344B1 (ko) | 1999-04-15 | 2007-05-29 | 브리스톨-마이어스스퀴브컴파니 | 환형 단백질 티로신 키나제 억제제 |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
US7141581B2 (en) | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
US6515004B1 (en) | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
AU2001230026A1 (en) * | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
AU2001249865A1 (en) | 2000-04-18 | 2001-10-30 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
CA2411928A1 (en) | 2000-08-09 | 2002-02-14 | Agouron Pharmaceuticals, Inc. | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclindependent kinases |
CA2411924A1 (en) | 2000-08-18 | 2002-02-28 | Agouron Pharmaceuticals, Inc. | Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting proteinkinases |
EP1712550A3 (de) * | 2000-12-22 | 2009-07-15 | Ortho-McNeil Pharmaceutical, Inc. | Substituite Triazoldiamin Derivate und ihre Verwendung als Kinase-Inhibitoren |
EP1355889B1 (de) | 2000-12-22 | 2006-06-07 | Ortho-McNeil Pharmaceutical, Inc. | Substituieten triazoldiamin derivaten und ihre verwendung als kinase inhibitoren |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
ES2255621T3 (es) * | 2001-06-22 | 2006-07-01 | MERCK & CO., INC. | Inhibidores de tirosina quinasa. |
HN2002000156A (es) * | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
CA2455753A1 (en) * | 2001-08-03 | 2003-02-13 | Novo Nordisk A/S | Novel 2,4-diaminothiazole derivatives |
CN101001857B (zh) | 2002-01-22 | 2011-06-22 | 沃尼尔·朗伯有限责任公司 | 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮 |
US6818663B2 (en) * | 2002-05-17 | 2004-11-16 | Hoffmann-La Roches | Diaminothiazoles |
UA77303C2 (en) | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
US6872724B2 (en) | 2002-07-24 | 2005-03-29 | Merck & Co., Inc. | Polymorphs with tyrosine kinase activity |
CA2493701A1 (en) | 2002-07-25 | 2004-02-05 | Pfizer Products Inc. | Isothiazole derivatives useful as anticancer agents |
EP1539722A1 (de) * | 2002-08-07 | 2005-06-15 | F. Hoffmann-La Roche Ag | Thiazolderivate |
US7157455B2 (en) | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
MXPA05008520A (es) * | 2003-02-12 | 2005-10-20 | Pfizer | Derivados de 2-(sulfo-fenil)-aminotiazol antiproliferativos. |
CA2516234A1 (en) * | 2003-02-21 | 2004-09-02 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
DE602004022668D1 (de) | 2003-06-03 | 2009-10-01 | Novartis Ag | 5-gliedrige heterocyclische p-38 inhibitoren |
DK1641764T3 (da) | 2003-06-26 | 2011-11-21 | Novartis Ag | P38-kinasehæmmere på grundlag af 5-leddede heterocykliske forbindelser |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
PL1651612T3 (pl) | 2003-07-22 | 2012-09-28 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
DK1651615T3 (da) | 2003-07-29 | 2010-05-25 | High Point Pharmaceuticals Llc | Pyridazinyl-piperaziner og anvendelse deraf som histamin-H3-receptorligander |
US20070275918A1 (en) * | 2003-11-07 | 2007-11-29 | The Board Of Trustees Of The University Of Illinois | Induction of Cellular Senescence by Cdk4 Disruption for Tumor Suppression and Regression |
JP2007513967A (ja) * | 2003-12-11 | 2007-05-31 | セラヴァンス, インコーポレーテッド | 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物 |
EP1550372A1 (de) * | 2003-12-24 | 2005-07-06 | Bayer CropScience GmbH | Pflanzenwachstumsregulierung |
WO2005073225A1 (en) * | 2004-01-30 | 2005-08-11 | Ab Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
JP2007531773A (ja) * | 2004-03-31 | 2007-11-08 | レキシコン・ジェネティクス・インコーポレーテッド | プロテインキナーゼ変調剤としての2−アミノメチルチアゾール−5−カルボキサミド |
US7211576B2 (en) * | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
EP1742627A4 (de) | 2004-05-06 | 2009-08-26 | Plexxikon Inc | Pde4b-hemmer und ihre verwendung |
US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
US7423051B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
US7423053B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
AU2005279795A1 (en) | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl PDE4B inhibitors |
US7253285B2 (en) * | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
US7241893B2 (en) * | 2004-09-17 | 2007-07-10 | Hoffman-La Roche Inc. | Thiazolinone 2-substituted quinolines |
ATE388149T1 (de) | 2004-10-14 | 2008-03-15 | Hoffmann La Roche | Neue azaindol-thiazolinone als krebsmittel |
US8110573B2 (en) | 2004-12-30 | 2012-02-07 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases |
US20080312223A1 (en) | 2004-12-30 | 2008-12-18 | Astex Therapeutics Limited | Thiazole And Isothiazole Derivatives That Modulate The Activity Of CDK, GSK And Aurora Kinases |
MX2007008781A (es) | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
JP5475234B2 (ja) | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
KR101286569B1 (ko) | 2005-07-04 | 2013-07-23 | 하이 포인트 파마슈티칼스, 엘엘씨 | 신규 약제 |
MX2008001428A (es) | 2005-07-30 | 2008-04-04 | Astrazeneca Ab | Compuestos de imidazolil-pirimidina para uso en el tratamiento de trastornos proliferativos. |
US7705009B2 (en) * | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
EP1999120B1 (de) | 2006-03-28 | 2012-06-27 | High Point Pharmaceuticals, LLC | Benzothiazole mit wirkung am histamin-h3-rezeptor |
EP2038256A1 (de) | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6-(4-cyclopropylpiperazin-1-yl)-2'-methyl-[3,4']-bipyridin und seine verwendung als arzneimittel |
DK2079732T3 (da) | 2006-05-29 | 2012-01-23 | High Point Pharmaceuticals Llc | 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazin, dets salte og solvater og dets anvendelse som histamin H3-receptorantagonister |
AU2008214679A1 (en) * | 2007-02-13 | 2008-08-21 | Ab Science | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors |
JP5264890B2 (ja) * | 2007-05-11 | 2013-08-14 | エフ.ホフマン−ラ ロシュ アーゲー | アミロイドベータの調節剤としてのヘタリールアニリン |
EP2014656A3 (de) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Neue heterocyclische H3-Antagonisten |
EP3399026A1 (de) | 2010-06-14 | 2018-11-07 | The Scripps Research Institute | Neuprogrammierung von zellen für ein neues zellschicksal |
EA032429B1 (ru) * | 2012-02-02 | 2019-05-31 | Сенекс Биотекнолоджи Инк. | Селективные низкомолекулярные ингибиторы cdk8/cdk19 и их применение в качестве агентов для лечения рака |
CN102977049A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-氨基-4-环丙基-5-羧酸乙酯噻唑的合成方法 |
WO2014182789A2 (en) * | 2013-05-07 | 2014-11-13 | The Regents Of The University Of California | Radiomitigating pharmaceutical formulations |
CN104628627A (zh) * | 2014-12-23 | 2015-05-20 | 安徽德信佳生物医药有限公司 | 一种1-boc-4-氨基哌啶的合成方法 |
CN106854200B (zh) * | 2015-12-08 | 2019-05-21 | 上海复星星泰医药科技有限公司 | 色瑞替尼及其中间体的制备方法 |
WO2018089902A1 (en) * | 2016-11-13 | 2018-05-17 | Apogee Biotechnology Corporation | Diaminothiazole compounds, compositions and methods of use |
EP3564232B1 (de) | 2016-12-27 | 2022-01-26 | Riken | Bmp-signalhemmende verbindung |
EP4219486A1 (de) * | 2017-01-19 | 2023-08-02 | Temple University of the Commonwealth System of Higher Education | Verbrückte bicycloalkyl-substituierte aminothizole und verfahren zu ihrer verwendung |
AU2019285066A1 (en) | 2018-06-15 | 2020-12-17 | Handa Pharmaceuticals, Inc. | Kinase inhibitor salts and compositions thereof |
CN109897014A (zh) * | 2019-04-17 | 2019-06-18 | 成都睿智化学研究有限公司 | 一种1-(取代苯基)-4-甲基哌嗪的工艺制备方法 |
CN114099503A (zh) * | 2020-09-01 | 2022-03-01 | 乔海灵 | 化合物作为cyp2e1抑制剂的应用 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3530161A (en) | 1968-08-19 | 1970-09-22 | Shell Oil Co | Aromatic isothiocyanate production |
BE792402A (fr) | 1971-12-07 | 1973-06-07 | Ciba Geigy | Composes heterocycliques azotes et medicaments anthelminthiqueset antimicrobiens qui en contiennent |
CH593806A5 (de) | 1974-11-14 | 1977-12-15 | Ciba Geigy Ag | |
US4086239A (en) | 1977-07-01 | 1978-04-25 | Stauffer Chemical Company | Thiazole bis-phosphates and phosphonates, intermediates, and insecticidal compositions and methods |
US4649146A (en) | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
DE3804531A1 (de) | 1988-02-13 | 1989-08-24 | Bayer Ag | 5-cyano-2,4-diamino-thiazol-derivate |
IE68593B1 (en) | 1989-12-06 | 1996-06-26 | Sanofi Sa | Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them |
US5620963A (en) | 1991-10-15 | 1997-04-15 | Isis Pharmaceuticals, Inc. | Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5409930A (en) * | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
ATE273386T1 (de) | 1991-09-20 | 2004-08-15 | Hutchinson Fred Cancer Res | Menschliches cyclin e |
US5262409A (en) | 1991-10-11 | 1993-11-16 | Fred Hutchinson Cancer Research Center | Binary tumor therapy |
US5441880A (en) | 1991-11-18 | 1995-08-15 | Cold Spring Harbor Laboratory | Human cdc25 genes, encoded products and uses thereof |
US5596079A (en) | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
US5302706A (en) | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
WO1993021230A1 (en) | 1992-04-10 | 1993-10-28 | Dana-Farber Cancer Institute, Inc. | Activation-state-specific phosphoprotein immunodetection |
WO1994007522A1 (en) | 1992-09-30 | 1994-04-14 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
US5543291A (en) | 1993-01-29 | 1996-08-06 | Dana Farber Cancer Institute | Method of detecting carcinoma |
CA2162586C (en) | 1993-05-13 | 2006-01-03 | David J. Grainger | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
US5443962A (en) | 1993-06-04 | 1995-08-22 | Mitotix, Inc. | Methods of identifying inhibitors of cdc25 phosphatase |
US5514571A (en) | 1993-08-05 | 1996-05-07 | University Technologies International Inc. | Cyclin D1 negative regulatory activity |
US5473056A (en) | 1993-10-13 | 1995-12-05 | Merck & Co., Inc. | E2F-2, a novel mammalian transcription factor |
US5532167A (en) | 1994-01-07 | 1996-07-02 | Beth Israel Hospital | Substrate specificity of protein kinases |
US5484710A (en) | 1994-01-14 | 1996-01-16 | La Jolla Cancer Research Foundation | Method of down-regulating a gene linked to a P-53 responsive element |
US5625031A (en) | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
EP0702730A4 (de) | 1994-03-18 | 1997-05-07 | Univ Utah Res Found | Kermbahnmütationen im mts-gen und methoden zur detektion einer veranlagung von krebs im mts-gen |
US5496831A (en) | 1994-05-13 | 1996-03-05 | The General Hospital Corporation | Inhibition of insulin-induced adiposis |
US5631156A (en) | 1994-06-21 | 1997-05-20 | The University Of Michigan | DNA encoding and 18 KD CDK6 inhibiting protein |
US5571523A (en) | 1995-03-09 | 1996-11-05 | President And Fellows Of Harvard College | Antioxidant-induced apoptosis in vascular smooth muscle cells |
US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
EP0874846B1 (de) | 1995-11-01 | 2003-04-02 | Novartis AG | Purinderivate und verfahren zu ihrer herstellung |
US5849733A (en) | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
TW513418B (en) | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
GB9621757D0 (en) | 1996-10-18 | 1996-12-11 | Ciba Geigy Ag | Phenyl-substituted bicyclic heterocyclyl derivatives and their use |
AU749750B2 (en) * | 1997-02-05 | 2002-07-04 | Warner-Lambert Company | Pyrido {2,3-d} pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
DE69835241T2 (de) * | 1997-10-27 | 2007-05-31 | Agouron Pharmaceuticals, Inc., La Jolla | 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen |
UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
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