DE69824876D1 - Knochenersatzmaterialien - Google Patents

Knochenersatzmaterialien

Info

Publication number
DE69824876D1
DE69824876D1 DE69824876T DE69824876T DE69824876D1 DE 69824876 D1 DE69824876 D1 DE 69824876D1 DE 69824876 T DE69824876 T DE 69824876T DE 69824876 T DE69824876 T DE 69824876T DE 69824876 D1 DE69824876 D1 DE 69824876D1
Authority
DE
Germany
Prior art keywords
bone replacement
replacement materials
materials
bone
replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824876T
Other languages
English (en)
Other versions
DE69824876T2 (de
Inventor
D Johnson
R Johnson
G Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philips Origen Ceramic Technology LLC
Original Assignee
Philips Origen Ceramic Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Origen Ceramic Technology LLC filed Critical Philips Origen Ceramic Technology LLC
Publication of DE69824876D1 publication Critical patent/DE69824876D1/de
Application granted granted Critical
Publication of DE69824876T2 publication Critical patent/DE69824876T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A61F2/3662—Femoral shafts
    • A61F2/367—Proximal or metaphyseal parts of shafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A61F2/389—Tibial components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30092—Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30884—Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30968—Sintering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00131—Tantalum or Ta-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
    • A61F2310/00203—Ceramics or ceramic-like structures based on metal oxides containing alumina or aluminium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
    • A61F2310/00239—Ceramics or ceramic-like structures based on metal oxides containing zirconia or zirconium oxide ZrO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
DE69824876T 1997-10-01 1998-09-30 Knochenersatzmaterialien Expired - Lifetime DE69824876T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/942,557 US6136029A (en) 1997-10-01 1997-10-01 Bone substitute materials
US942557 1997-10-01
PCT/US1998/020549 WO1999016479A1 (en) 1997-10-01 1998-09-30 Bone substitute materials

Publications (2)

Publication Number Publication Date
DE69824876D1 true DE69824876D1 (de) 2004-08-05
DE69824876T2 DE69824876T2 (de) 2005-07-14

Family

ID=25478272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824876T Expired - Lifetime DE69824876T2 (de) 1997-10-01 1998-09-30 Knochenersatzmaterialien

Country Status (8)

Country Link
US (1) US6136029A (de)
EP (1) EP1024840B1 (de)
JP (1) JP4101458B2 (de)
CN (1) CN1230207C (de)
AU (1) AU736513B2 (de)
CA (1) CA2305431C (de)
DE (1) DE69824876T2 (de)
WO (1) WO1999016479A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667049B2 (en) 1999-06-14 2003-12-23 Ethicon, Inc. Relic process for producing bioresorbable ceramic tissue scaffolds
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6451059B1 (en) * 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
US6723334B1 (en) * 2000-03-01 2004-04-20 Iowa State University Research Foundation, Inc. Biologically compatible bone cements and orthopedic methods
US7001551B2 (en) * 2000-07-13 2006-02-21 Allograft Research Technologies, Inc. Method of forming a composite bone material implant
US6599516B1 (en) 2000-09-14 2003-07-29 Etex Corporation Malleable implant containing solid element that resorbs or fractures to provide access channels
US7052517B2 (en) * 2000-10-24 2006-05-30 Vita Special Purpose Corporation Delivery device for biological composites and method of preparation thereof
US6736799B1 (en) 2000-10-24 2004-05-18 Vita Licensing, Inc. Delivery device for biological composites and method of preparation thereof
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
WO2002059395A2 (en) * 2000-12-28 2002-08-01 The Board Of Regents Of The University Of Nebraska Electrolytic deposition of coatings for prosthetic metals and alloys
US7294187B2 (en) * 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
US6793725B2 (en) 2001-01-24 2004-09-21 Ada Foundation Premixed calcium phosphate cement pastes
US7709029B2 (en) * 2001-01-24 2010-05-04 Ada Foundation Calcium-containing restoration materials
CA2438801A1 (en) * 2001-02-19 2002-08-29 Isotis N.V. Porous metals and metal coatings for implants
US8123814B2 (en) 2001-02-23 2012-02-28 Biomet Manufacturing Corp. Method and appartus for acetabular reconstruction
US7597715B2 (en) 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
CA2442855A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
US20050177237A1 (en) * 2001-04-12 2005-08-11 Ben Shappley Spinal cage insert, filler piece and method of manufacturing
EP1492475B1 (de) 2001-04-16 2011-12-21 Wright Medical Technology, Inc. Dichte/poröse strukturen zur verwendung als knochenersatz
FI117963B (fi) * 2001-04-26 2007-05-15 Eija Marjut Pirhonen Luuta korvaavat materiaalit
EP1389978B1 (de) * 2001-05-01 2009-01-07 Amedica Corporation Röntgendurchlässiges knochentransplantat
US7776085B2 (en) 2001-05-01 2010-08-17 Amedica Corporation Knee prosthesis with ceramic tibial component
US7695521B2 (en) * 2001-05-01 2010-04-13 Amedica Corporation Hip prosthesis with monoblock ceramic acetabular cup
AU2002324443A1 (en) 2001-06-14 2003-01-02 Amedica Corporation Metal-ceramic composite articulation
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20030065397A1 (en) 2001-08-27 2003-04-03 Hanssen Arlen D. Prosthetic implant support structure
US7892288B2 (en) * 2001-08-27 2011-02-22 Zimmer Technology, Inc. Femoral augments for use with knee joint prosthesis
US20040162619A1 (en) * 2001-08-27 2004-08-19 Zimmer Technology, Inc. Tibial augments for use with knee joint prostheses, method of implanting the tibial augment, and associated tools
EP1429817B8 (de) * 2001-09-24 2007-09-12 Millenium Biologix Technologies Inc. Poröse keramische komposit-knochenimplantate
ATE319760T1 (de) * 2001-12-21 2006-03-15 Isotis Orthobiologics Inc Zusammensetzungen enthaltend endgruppen-verkappte polyalkylenglykole
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
DE10201340A1 (de) * 2002-01-16 2003-07-24 Biovision Gmbh Knochen-Ersatzmaterial und Verfahren zu seiner Herstellung
US6955716B2 (en) 2002-03-01 2005-10-18 American Dental Association Foundation Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
US7159272B2 (en) * 2002-05-14 2007-01-09 Emerson Electric Co. Detachable accessory holder
US20030220696A1 (en) * 2002-05-23 2003-11-27 Levine David Jerome Implantable porous metal
US20030225347A1 (en) * 2002-06-03 2003-12-04 Argenta Louis C. Directed tissue growth employing reduced pressure
US6797006B2 (en) * 2002-06-18 2004-09-28 Zimmer Technology, Inc. Porous unicondylar knee
USD684693S1 (en) 2002-08-22 2013-06-18 Zimmer, Inc. Prosthetic implant support structure
US6744454B2 (en) * 2002-10-18 2004-06-01 Eastman Kodak Company Method and apparatus for reducing uneven use of heating elements on thermal print head
US7323011B2 (en) * 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US7309361B2 (en) * 2002-10-23 2007-12-18 Wasielewski Ray C Biologic modular tibial and femoral component augments for use with total knee arthroplasty
US6761739B2 (en) * 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
WO2004058098A2 (en) 2002-12-17 2004-07-15 Amedica Corporation Total disc implant
EP1601632B1 (de) * 2003-01-23 2010-08-25 University Of Bath Knochenersatzmaterial
US20050158535A1 (en) * 2003-05-15 2005-07-21 Miqin Zhang Methods for making porous ceramic structures
GB0318901D0 (en) * 2003-08-12 2003-09-17 Univ Bath Improvements in or relating to bone substitute material
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
EP1789088A4 (de) 2004-03-24 2009-12-30 Doctor S Res Group Inc Verfahren zur durchführung von medizinischen verfahren zur förderung des knochenwachstums, verfahren zur herstellung von zusammensetzungen zur förderung des knochenwachstums und gerät zur verwendung bei solchen verfahren
US7384430B2 (en) * 2004-06-30 2008-06-10 Depuy Products, Inc. Low crystalline polymeric material for orthopaedic implants and an associated method
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
US7879275B2 (en) * 2004-12-30 2011-02-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7896921B2 (en) * 2004-12-30 2011-03-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7883653B2 (en) 2004-12-30 2011-02-08 Depuy Products, Inc. Method of making an implantable orthopaedic bearing
US8221504B2 (en) 2005-02-23 2012-07-17 Wright Medical Technology, Inc. Coating an implant for increased bone in-growth
US8066778B2 (en) 2005-04-21 2011-11-29 Biomet Manufacturing Corp. Porous metal cup with cobalt bearing surface
US8021432B2 (en) 2005-12-05 2011-09-20 Biomet Manufacturing Corp. Apparatus for use of porous implants
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8266780B2 (en) 2005-04-21 2012-09-18 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
CA2619469C (en) 2005-09-09 2015-03-03 Wright Medical Technology, Inc. Composite bone graft cement comprising calcium sulfate dihydrate and brushite
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
EP1951156A2 (de) * 2005-11-18 2008-08-06 Ceramatec, Inc. Poröses, belastbares implantat aus keramik oder metall
EP1991282B1 (de) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Zusammensetzungen und verfahren zur behandlung von knochen
US8252058B2 (en) 2006-02-16 2012-08-28 Amedica Corporation Spinal implant with elliptical articulatory interface
WO2007105600A1 (ja) * 2006-03-10 2007-09-20 Takiron Co., Ltd. インプラント複合材料
US20100131064A1 (en) * 2006-04-05 2010-05-27 University Of Nebraska Bioresorbable polymer reconstituted bone and methods of formation thereof
US9101505B2 (en) * 2006-04-27 2015-08-11 Brs Holdings, Llc Composite stent
US9155646B2 (en) * 2006-04-27 2015-10-13 Brs Holdings, Llc Composite stent with bioremovable ceramic flakes
US20070260324A1 (en) * 2006-05-05 2007-11-08 Joshi Ashok V Fully or Partially Bioresorbable Orthopedic Implant
EP2040765A2 (de) 2006-06-29 2009-04-01 Orthovita, INC. Bioaktiver knochentransplantatersatz
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
ES2664229T3 (es) 2006-06-30 2018-04-18 Biomimetic Therapeutics, Llc Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador
US20080022644A1 (en) * 2006-07-28 2008-01-31 Derosa Michael Edward Reticulated pore formers for ceramic articles
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8157869B2 (en) 2007-01-10 2012-04-17 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US8562616B2 (en) 2007-10-10 2013-10-22 Biomet Manufacturing, Llc Knee joint prosthesis system and method for implantation
US8187280B2 (en) 2007-10-10 2012-05-29 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US8163028B2 (en) 2007-01-10 2012-04-24 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US8328873B2 (en) 2007-01-10 2012-12-11 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US8512342B2 (en) * 2007-08-11 2013-08-20 Thomas L. Meredith Portable bone grinder
DE102008044951A1 (de) * 2008-02-05 2009-08-06 Smith & Nephew Orthopaedics Ag Offenporige biokompatible Oberflächenschicht für ein Implantat, Verfahren zur Herstellung und Verwendung
CN102014977B (zh) 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 用于牵引成骨术的组合物和方法
US20090248162A1 (en) * 2008-03-25 2009-10-01 Warsaw Orthopedic, Inc. Microparticle delivery syringe and needle for placing suspensions and removing vehicle fluid
EP2130516B1 (de) * 2008-06-03 2014-03-05 DePuy (Ireland) Poröse Titan-Schienbeinhülsen
EP2130518B1 (de) 2008-06-03 2013-05-15 DePuy Products, Inc. Poröse Titan-Oberschenkelhülsen
US20090304775A1 (en) * 2008-06-04 2009-12-10 Joshi Ashok V Drug-Exuding Orthopedic Implant
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
CA2734183C (en) * 2008-08-13 2016-11-01 Smed-Ta/Td, Llc Orthopaedic implant with spatially varying porosity
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US20100042213A1 (en) * 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
JP5774989B2 (ja) 2008-08-13 2015-09-09 スメド−ティーエイ／ティーディー・エルエルシー 整形外科用ねじ
WO2010025386A1 (en) * 2008-08-29 2010-03-04 Smed-Ta/Td, Llc Orthopaedic implant
CN102231992B (zh) 2008-09-09 2015-05-20 生物模拟治疗公司 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法
US8614189B2 (en) * 2008-09-24 2013-12-24 University Of Connecticut Carbon nanotube composite scaffolds for bone tissue engineering
US20100125335A1 (en) * 2008-11-20 2010-05-20 Daley Robert J Methods and apparatus for replacing biological joints using bone cement in a suspended state
US20100125303A1 (en) * 2008-11-20 2010-05-20 Daley Robert J Methods and apparatus for replacing biological joints using bone mineral substance in a suspended state
EP2401000A2 (de) * 2009-02-25 2012-01-04 Howmedica Osteonics Corp. Haltestrukturen für knochentransplantatmaterial
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
US9399086B2 (en) 2009-07-24 2016-07-26 Warsaw Orthopedic, Inc Implantable medical devices
IN2012DN01464A (de) * 2009-08-19 2015-06-05 Smith & Nephew Inc
MX2012009687A (es) 2010-02-22 2012-11-29 Biomimetic Therapeutics Inc Metodos y composiciones de factor de crecimiento derivado de plaquetas y métodos para el tratamiento de tendinopatías.
US8795691B2 (en) * 2010-03-16 2014-08-05 Brown University Nanotubes and compositions thereof
AU2011251991B2 (en) 2010-05-10 2014-05-22 University Of Connecticut Lactoferrin -based biomaterials for tissue regeneration and drug delivery
CA2798710C (en) 2010-05-11 2019-08-27 Venkat R. Garigapati Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
US9878272B2 (en) 2010-05-28 2018-01-30 Corning Incorporated Porous inorganic membranes and method of manufacture
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
US8900317B2 (en) 2011-05-20 2014-12-02 Zimmer, Inc. Stabilizing prosthesis support structure
GB201119966D0 (en) * 2011-11-18 2012-01-04 Biocomposites Ltd Mould mat for producing bone cement pellets
US9180223B2 (en) 2012-05-10 2015-11-10 The Trustees Of The Stevens Institute Of Technology Biphasic osteochondral scaffold for reconstruction of articular cartilage
BR102012032608B1 (pt) * 2012-12-18 2021-06-01 Universidade Estadual De Campinas - Unicamp Processo de obtenção de esponjas de hidroxiapatita e fosfato tricálcico, esponjas assim obtidas e uso das mesmas
US9681966B2 (en) 2013-03-15 2017-06-20 Smed-Ta/Td, Llc Method of manufacturing a tubular medical implant
US9724203B2 (en) 2013-03-15 2017-08-08 Smed-Ta/Td, Llc Porous tissue ingrowth structure
US9408699B2 (en) 2013-03-15 2016-08-09 Smed-Ta/Td, Llc Removable augment for medical implant
US10118827B2 (en) * 2013-05-10 2018-11-06 Reed A. Ayers Combustion synthesis of calcium phosphate constructs and powders doped with atoms, molecules, ions, or compounds
AU2014331971B2 (en) * 2013-10-08 2018-07-19 Vivorte, Inc. Processed bone particle compositions and related methods
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
CN105343935A (zh) * 2014-12-15 2016-02-24 四川大学 一种磷酸钙晶须骨架和多孔复合支架及其制备方法
EP3570787B1 (de) 2017-01-20 2022-05-04 Biomet Manufacturing, LLC Modulare vegrösserungskomponente
WO2018220848A1 (ja) * 2017-06-02 2018-12-06 オリンパス株式会社 骨補填材及び骨補填材の製造方法
TWI647032B (zh) * 2017-12-28 2019-01-11 財團法人工業技術研究院 醫療元件的製作方法及其應用
US10512495B2 (en) 2017-12-28 2019-12-24 Industrial Technology Research Institute Method for fabricating medical device and applications thereof
CN109730811B (zh) * 2018-12-17 2021-07-13 中国科学院上海硅酸盐研究所 仿骨哈弗斯系统生物活性支架及其制备方法和应用
EP3908338A4 (de) * 2019-01-10 2022-09-07 University of Utah Research Foundation Fluorapatitbeschichtete implantate und zugehörige verfahren
CN114026882A (zh) * 2019-06-28 2022-02-08 富士胶片株式会社 压电薄膜
USD901014S1 (en) 2019-08-12 2020-11-03 Ortho Development Corporation Porous implant
USD901012S1 (en) 2019-08-12 2020-11-03 Ortho Development Corporation Porous implant
US11565021B1 (en) 2019-08-12 2023-01-31 Ortho Development Corporation Composite structure porous implant for replacing bone stock
USD901013S1 (en) 2019-08-12 2020-11-03 Ortho Development Corporation Porous implant
US11498124B1 (en) 2019-11-25 2022-11-15 Ortho Development Corporation Method for sintering porous structures from powder using additive manufacturing
CN110882417B (zh) * 2019-12-20 2021-02-19 上海贝奥路生物材料有限公司 复合多孔生物陶瓷的金属假体及其制备方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000525A (en) * 1975-08-21 1977-01-04 The United States Of America As Represented By The Secretary Of The Navy Ceramic prosthetic implant suitable for a knee joint plateau
US4237559A (en) * 1979-05-11 1980-12-09 General Electric Company Bone implant embodying a composite high and low density fired ceramic construction
DE2928007A1 (de) * 1979-07-11 1981-01-15 Riess Guido Dr Knochen-implantatkoerper fuer prothesen und knochenverbindungsstuecke sowie verfahren zu seiner herstellung
US4343704A (en) * 1981-01-22 1982-08-10 Swiss Aluminium Ltd. Ceramic foam filter
US4626392A (en) * 1984-03-28 1986-12-02 Ngk Spark Plug Co., Ltd. Process for producing ceramic body for surgical implantation
US5001169A (en) * 1984-10-24 1991-03-19 Collagen Corporation Inductive collagen-based bone repair preparations
US5522894A (en) * 1984-12-14 1996-06-04 Draenert; Klaus Bone replacement material made of absorbable beads
US4722870A (en) * 1985-01-22 1988-02-02 Interpore International Metal-ceramic composite material useful for implant devices
US5007930A (en) * 1985-02-19 1991-04-16 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US5133755A (en) * 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
JPS62202884A (ja) * 1986-02-28 1987-09-07 工業技術院長 生体代替セラミツク材料
FI80605C (fi) * 1986-11-03 1990-07-10 Biocon Oy Benkirurgisk biokompositmaterial.
JPS6418973A (en) * 1987-07-10 1989-01-23 Agency Ind Science Techn Bioceramic material
DE68917947T2 (de) * 1988-02-08 1995-03-16 Mitsubishi Chem Ind Keramisches Implantat und Verfahren zu dessen Herstellung.
US5185177A (en) * 1988-02-08 1993-02-09 Mitsubishi Kasei Corporation Producing a ceramic implant by coating a powder mixture of zirconia and either tricalcium phosphate or hydroxyapatite on a molded unsintered body of partially stabilized zirconia and then sintering the article
US5192325A (en) * 1988-02-08 1993-03-09 Mitsubishi Kasei Corporation Ceramic implant
SE465571B (sv) * 1989-04-10 1991-09-30 Stiftelsen Ct Foer Dentaltekni Saett att framstaella ett sammansatt keramiskt material med bioaktiva egenskaper
US4976736A (en) * 1989-04-28 1990-12-11 Interpore International Coated biomaterials and methods for making same
US5344456A (en) * 1989-06-06 1994-09-06 Tdk Corporation Materials for living hard tissue replacements
EP0405556B1 (de) * 1989-06-30 1996-05-22 TDK Corporation Ersatzmaterial für lebende Hartgewebe, seine Herstellung und Herstellung eines Formkörpers
US5037438A (en) * 1989-07-25 1991-08-06 Richards Medical Company Zirconium oxide coated prosthesis for wear and corrosion resistance
US5152791A (en) * 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US4967509A (en) * 1990-01-05 1990-11-06 Storey Leonard M Security window shutter
JP2921918B2 (ja) * 1990-05-07 1999-07-19 旭光学工業株式会社 多相構造の生体材料及びその製造方法
US5231169A (en) * 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
US5205921A (en) * 1991-02-04 1993-04-27 Queen's University At Kingston Method for depositing bioactive coatings on conductive substrates
JP3007903B2 (ja) * 1991-03-29 2000-02-14 京セラ株式会社 人工椎間板
SE469653B (sv) * 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
US5282861A (en) * 1992-03-11 1994-02-01 Ultramet Open cell tantalum structures for cancellous bone implants and cell and tissue receptors
JP3362267B2 (ja) * 1993-12-29 2003-01-07 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
US5549685A (en) * 1994-02-23 1996-08-27 Zimmer, Inc. Augmentation for an orthopaedic implant
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6105235A (en) * 1994-04-28 2000-08-22 Johnson & Johnson Professional, Inc. Ceramic/metallic articulation component and prosthesis
WO1995032008A1 (en) * 1994-05-24 1995-11-30 Implico B.V. A biomaterial and bone implant for bone repair and replacement
AU3795395A (en) * 1994-11-30 1996-06-06 Ethicon Inc. Hard tissue bone cements and substitutes
DE19504955A1 (de) * 1995-02-15 1996-08-22 Merck Patent Gmbh Verfahren zur Herstellung von Spongiosa-Knochenkeramikformkörpern
US5783248A (en) * 1995-08-28 1998-07-21 National Science Council Of R.O.C. Process for producing a bioceramic composite material containing natural bone material on an alumina substrate
DE19610715C1 (de) * 1996-03-19 1997-06-26 Axel Kirsch Verfahren zum Herstellen eines Knochenersatzmaterials

Also Published As

Publication number Publication date
CA2305431A1 (en) 1999-04-08
AU9594198A (en) 1999-04-23
CN1230207C (zh) 2005-12-07
CA2305431C (en) 2009-09-08
DE69824876T2 (de) 2005-07-14
JP4101458B2 (ja) 2008-06-18
CN1290181A (zh) 2001-04-04
WO1999016479A1 (en) 1999-04-08
EP1024840A1 (de) 2000-08-09
EP1024840B1 (de) 2004-06-30
JP2001518322A (ja) 2001-10-16
AU736513B2 (en) 2001-07-26
US6136029A (en) 2000-10-24

Similar Documents

Publication Publication Date Title
DE69824876D1 (de) Knochenersatzmaterialien
DE59809812D1 (de) Knochen- und knorpel-ersatzstrukturen
FR2787020B1 (fr) Implant intervertebral
DE69834425D1 (de) Unterstütztes implantat
PT973746E (pt) 3-ciano-quinolinas substituidas
FR2759576B1 (fr) Implant de sclero-keratectomie pre-descemetique
ID24176A (id) Bahan pembantu sementasi
DE69823955D1 (de) Als knochenimplantat geeignetes erzeugnis
DE59710145D1 (de) Symmetrische knochenplatte
DE69827462D1 (de) Hüftschaft-Zementabstandshalter
DE59700099D1 (de) Knochenplatte
DE69832542D1 (de) Fusionsimplantat
DE69722320D1 (de) Skelettimplantat
DE59804367D1 (de) Sterilisierbehälter
DE69715264D1 (de) Knochenprothese
DE69802670D1 (de) Flash-gesponnenes flächiges material
DE69826451D1 (de) Anästehischer knochenzement
DE69916159D1 (de) Skelettimplantat
ATA144897A (de) Wirbelsäulen-prothese
ID28852A (id) Bahan-bahan elektroluminesensi
PT1036083E (pt) Novos 9a-azalidos
FI972210A (fi) Hiostamaton materiaali
DE29703971U1 (de) Knochenprothese
DE69827886D1 (de) Entnahmegefässanordnung
DE69805291D1 (de) Teilcheförmiges hydrogelmaterial

Legal Events

Date Code Title Description
8364 No opposition during term of opposition