DE69814639D1 - Nicht-invasive pränatale diagnose - Google Patents

Nicht-invasive pränatale diagnose

Info

Publication number
DE69814639D1
DE69814639D1 DE69814639T DE69814639T DE69814639D1 DE 69814639 D1 DE69814639 D1 DE 69814639D1 DE 69814639 T DE69814639 T DE 69814639T DE 69814639 T DE69814639 T DE 69814639T DE 69814639 D1 DE69814639 D1 DE 69814639D1
Authority
DE
Germany
Prior art keywords
prenatal diagnosis
invasive prenatal
detection
sample
eclampsia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814639T
Other languages
English (en)
Other versions
DE69814639T3 (de
DE69814639T2 (de
Inventor
Dennis Lo
Stephen Wainscoat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10808662&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69814639(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of DE69814639D1 publication Critical patent/DE69814639D1/de
Application granted granted Critical
Publication of DE69814639T2 publication Critical patent/DE69814639T2/de
Publication of DE69814639T3 publication Critical patent/DE69814639T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6879Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
DE69814639T 1997-03-04 1998-03-04 Nicht-invasive pränatale diagnose Expired - Lifetime DE69814639T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9704444.0A GB9704444D0 (en) 1997-03-04 1997-03-04 Non-invasive prenatal diagnosis
GB9704444 1997-03-04
PCT/GB1998/000690 WO1998039474A1 (en) 1997-03-04 1998-03-04 Non-invasive prenatal diagnosis
EP98910845A EP0994963B2 (de) 1997-03-04 1998-03-04 Nicht-invasive pränatale diagnose

Publications (3)

Publication Number Publication Date
DE69814639D1 true DE69814639D1 (de) 2003-06-18
DE69814639T2 DE69814639T2 (de) 2004-03-25
DE69814639T3 DE69814639T3 (de) 2012-09-13

Family

ID=10808662

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814639T Expired - Lifetime DE69814639T3 (de) 1997-03-04 1998-03-04 Nicht-invasive pränatale diagnose

Country Status (13)

Country Link
US (1) US6258540B1 (de)
EP (1) EP0994963B2 (de)
JP (1) JP4245666B2 (de)
AT (1) ATE240409T1 (de)
AU (1) AU727919B2 (de)
CA (1) CA2282793C (de)
DE (1) DE69814639T3 (de)
DK (1) DK0994963T4 (de)
ES (1) ES2198700T5 (de)
GB (1) GB9704444D0 (de)
HK (1) HK1026720A1 (de)
PT (1) PT994963E (de)
WO (1) WO1998039474A1 (de)

Families Citing this family (304)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136311A (en) * 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US7767422B2 (en) * 1998-09-22 2010-08-03 Oncomedx, Inc. Detection of 5T4 RNA in plasma and serum
EP1198585B1 (de) * 1999-06-28 2007-06-13 Source Precision Medicine, Inc. Verfahren zum Charakterisieren von biologischen Bedingungen, die kalibrierte Genexpressionsprofile verwenden
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
GB0009784D0 (en) * 2000-04-20 2000-06-07 Simeg Limited Methods for clinical diagnosis
GB0016742D0 (en) * 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
US7083924B2 (en) 2000-07-10 2006-08-01 Btg International Limited Diagnostic method for the identification of foetal DNA in a material sample
EP1354060B1 (de) * 2000-08-28 2011-02-09 Oncomedx, Inc. 5t4 rna in plasma und serum als marker für neoplastische erkrankungen
US6664056B2 (en) 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
US20090226915A1 (en) * 2001-01-24 2009-09-10 Health Discovery Corporation Methods for Screening, Predicting and Monitoring Prostate Cancer
EP2186901B1 (de) * 2001-06-14 2015-06-03 The Regents of The University of California Mutationen in der mit der Resistenz gegenüber STI-571 assoziierten BCR-abl-Tyrosinkinase
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
EP1468104A4 (de) * 2002-01-18 2006-02-01 Genzyme Corp Verfahren zum nachweis fötaler dna und zur allelquantifizierung
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
JP2006523082A (ja) * 2002-03-01 2006-10-12 ラブジェン, インコーポレイテッド ゲノム内の変異の迅速分析
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
JP2006501449A (ja) 2002-09-27 2006-01-12 ザ ジェネラル ホスピタル コーポレーション 細胞分離のためのマイクロ流体デバイスおよびその使用
CA2445204C (en) 2002-10-16 2014-08-12 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
DE10254601A1 (de) * 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
ES2542328T3 (es) * 2002-12-06 2015-08-04 Millennium Pharmaceuticals, Inc. Métodos para la identificación, evaluación y tratamiento de pacientes con terapia de inhibición del proteasoma
CA2513292C (en) 2003-01-17 2016-04-05 The Chinese University Of Hong Kong Circulating mrna as diagnostic markers for pregnancy-related disorders
EP1664077B1 (de) * 2003-09-05 2016-04-13 Trustees of Boston University Verfahren zur nichtinvasiven pränatalen diagnose
DE60328193D1 (de) 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
JP2007526761A (ja) * 2003-10-31 2007-09-20 ヴィタテックス, インコーポレイテッド 循環性の腫瘍細胞および内皮細胞の検出のための血液試験のプロトタイプおよび方法
WO2005072133A2 (en) * 2004-01-27 2005-08-11 Zoragen, Inc. Nucleic acid detection
EP1720636A4 (de) 2004-02-02 2012-06-20 Univ British Columbia Scodaphorese und verfahren und vorrichtungen zum bewegen und aufkonzentrieren von teilchen
US8529744B2 (en) 2004-02-02 2013-09-10 Boreal Genomics Corp. Enrichment of nucleic acid targets
US10337054B2 (en) 2004-02-02 2019-07-02 Quantum-Si Incorporated Enrichment of nucleic acid targets
WO2005080570A1 (ja) * 2004-02-24 2005-09-01 Mitsubishi Rayon Co., Ltd. 乳癌の術後予後予測に関与する遺伝子
WO2005111244A2 (en) * 2004-05-10 2005-11-24 Exact Sciences Corporation Methods for detecting a mutant nucleic acid
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
US7981607B2 (en) * 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
US8024128B2 (en) * 2004-09-07 2011-09-20 Gene Security Network, Inc. System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US11105808B2 (en) 2004-11-12 2021-08-31 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
WO2006089212A2 (en) * 2005-02-18 2006-08-24 Children's Medical Center Corporation Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin
JP5595657B2 (ja) * 2005-04-01 2014-09-24 メドベット サイエンス ピーティーワイ. リミティッド 診断法および治療法ならびにそれに有用な薬剤
US20070026418A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
EP1886138A4 (de) * 2005-05-11 2009-04-15 Genetic Technologies Ltd Verfahren zur anreicherung fötaler zellen
WO2007044091A2 (en) * 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8515679B2 (en) * 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
PT2385143T (pt) 2006-02-02 2016-10-18 Univ Leland Stanford Junior Rastreio genético fetal não-invasivo por análise digital
ATE508209T1 (de) * 2006-02-28 2011-05-15 Univ Louisville Res Found Erkennung von chromosomabnormalitäten im fötus mit hilfe der tandem-einzelnukleotid- polymorphismen
US8609338B2 (en) * 2006-02-28 2013-12-17 University Of Louisville Research Foundation, Inc. Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
US7901884B2 (en) 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
WO2008016186A1 (fr) * 2006-08-03 2008-02-07 The University Of Tokyo Anticorps spécifique dirigé contre l'autotaxine humaine intacte, procédé de criblage dudit anticorps et procédé et réactif destinés à l'examen d'un lymphome malin par une analyse de l'autotaxine
GB0616045D0 (en) * 2006-08-11 2006-09-20 Univ Bristol Blood cell separation
TWI335354B (en) * 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
DK2140269T3 (da) 2007-03-27 2013-12-16 Immunovia Ab Proteinsignatur/markører til at detektere adenocarcinom
WO2008134881A1 (en) * 2007-05-05 2008-11-13 The University Of Western Ontario Methods for the detection of preeclampsia
WO2008143896A1 (en) * 2007-05-14 2008-11-27 The Johns Hopkins University Methylation markers for prostate cancer and methods of use
US20100112590A1 (en) * 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
EP3067807A1 (de) 2007-07-23 2016-09-14 The Chinese University of Hong Kong Diagnose der fötalen chromosomalen aneuploidisierung unter verwendung von genomsequenzierung
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
WO2009092068A1 (en) 2008-01-18 2009-07-23 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
WO2009094772A1 (en) 2008-02-01 2009-08-06 The University Of British Columbia Methods and apparatus for particle introduction and recovery
WO2009102632A2 (en) * 2008-02-12 2009-08-20 Biocept, Inc. Method for isolating cell free apoptotic or fetal nucleic acids
WO2009105531A1 (en) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US8709726B2 (en) * 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US10996218B2 (en) 2008-03-11 2021-05-04 Ournextbaby Llc Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles
WO2009114579A2 (en) * 2008-03-11 2009-09-17 Urobiogics Llc Reducing/oxidizing activity of maternal urine as indicator of fetal gender related characteristics
WO2009146335A1 (en) * 2008-05-27 2009-12-03 Gene Security Network, Inc. Methods for embryo characterization and comparison
ES2620431T3 (es) * 2008-08-04 2017-06-28 Natera, Inc. Métodos para la determinación de alelos y de ploidía
EP2329021B1 (de) 2008-09-16 2016-08-10 Sequenom, Inc. Verfahren und zusammensetzungen zur methylierungsbasierten anreicherung fetaler nukleinsäure aus einer mütterlichen probe für nicht-invasive pränatale diagnose
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2952589B1 (de) 2008-09-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Nicht invasive diagnose von fötaler aneuploidie durch sequenzierung
US20110159499A1 (en) * 2009-11-25 2011-06-30 Quantalife, Inc. Methods and compositions for detecting genetic material
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8236503B2 (en) 2008-11-07 2012-08-07 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US20100167271A1 (en) * 2008-12-30 2010-07-01 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
ES2726702T3 (es) 2009-01-15 2019-10-08 Adaptive Biotechnologies Corp Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
DE202010018561U1 (de) 2009-01-21 2017-08-28 Streck Inc. Blutsammelröhrchen
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
WO2010091253A1 (en) 2009-02-06 2010-08-12 Women & Infants' Hospital Of Rhode Island Compositions, formulations and methods of treating preeclampsia-type disorders of pregnancy
DK3290530T3 (da) 2009-02-18 2020-12-07 Streck Inc Konservering af cellefrie nukleinsyrer
EP2408936A4 (de) * 2009-03-18 2013-01-30 Sequenom Inc Verwendung wärmestabiler endonukleasen zur herstellung von reportermolekülen
US8877028B2 (en) 2009-04-21 2014-11-04 The University Of British Columbia System and methods for detection of particles
AU2010239131A1 (en) 2009-04-21 2011-11-17 Genetic Technologies Limited Methods for obtaining fetal genetic material
WO2010123626A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms and expression predict clinical outcome in patients with cancer
CN102459643B (zh) 2009-06-25 2016-06-01 弗雷德哈钦森癌症研究中心 检测获得性免疫的方法
US10017812B2 (en) 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
KR101117916B1 (ko) 2009-07-30 2012-02-24 삼성메디슨 주식회사 새지털 뷰를 검출하는 초음파 시스템 및 방법
US20110070590A1 (en) 2009-09-22 2011-03-24 Jan Rohozinski Primers and Methods for Determining RhD Zygosity
US20120185176A1 (en) 2009-09-30 2012-07-19 Natera, Inc. Methods for Non-Invasive Prenatal Ploidy Calling
AU2010315037B9 (en) 2009-11-05 2015-04-23 Sequenom, Inc. Fetal genomic analysis from a maternal biological sample
EP2496720B1 (de) 2009-11-06 2020-07-08 The Board of Trustees of the Leland Stanford Junior University Nichtinvasive diagnose von transplantatabstossungen bei patienten mit organtransplantaten
EP2499259B1 (de) * 2009-11-09 2016-04-06 Streck Inc. Stabilisierung von rna in und extraktion aus intakten zellen in einer blutprobe
GB0921873D0 (en) * 2009-12-15 2010-01-27 Cytosystems Ltd Assay
WO2011084757A1 (en) 2009-12-21 2011-07-14 University Of Southern California Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer
EP2516680B1 (de) 2009-12-22 2016-04-06 Sequenom, Inc. Verfahren und kits zur identifizierung von aneuploidie
AU2010336017B2 (en) 2009-12-23 2016-04-28 Genetic Technologies Limited Methods of enriching and detecting fetal nucleic acids
WO2011085334A1 (en) 2010-01-11 2011-07-14 University Of Southern California Cd44 polymorphisms predict clinical outcome in patients with gastric cancer
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
AU2011207561B2 (en) 2010-01-19 2014-02-20 Verinata Health, Inc. Partition defined detection methods
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
AU2011207544A1 (en) * 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
US20120010085A1 (en) 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
EP2883965B8 (de) 2010-01-19 2018-06-27 Verinata Health, Inc Verfahren zur Bestimmung von Kopienummer-Variationen
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
KR101533469B1 (ko) * 2010-02-03 2015-07-02 연세대학교 산학협력단 Ras의 Thr-144번과 Thr-148번의 인산화의 감지를 통한 암 진단 방법, 항암제 스크리닝 및 약효테스트 방법
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
CA2798758C (en) 2010-05-18 2019-05-07 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
AU2011280936A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
SG10201505723UA (en) 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
WO2012012725A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting diseases or conditions using phagocytic cells
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
EP3153861A3 (de) * 2010-08-06 2017-06-07 The United States of America, as represented by The Secretary, Department of Health and Human Services Biomarker zur vorhersage des ansprechens auf einen krebsimpfstoff
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) * 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
EP2603607B1 (de) 2010-08-11 2016-04-06 Celula, Inc. Dns genotypisierung
EP2619573B1 (de) * 2010-09-16 2017-06-14 Urobiologics LLC Verwendung des harns von weiblichen säugetieren zur bestimmung von fetalen geschlechtsspezifischen merkmalen
EP2633311A4 (de) 2010-10-26 2014-05-07 Univ Stanford Nichtinvasives fötales genetisches screening durch sequenzierungsanalyse
CL2010001419A1 (es) * 2010-12-10 2011-04-25 Aquainnovo S A Metodo para detectar el sexo de forma prenatal en el plasma de madre, mediante el uso de la reaccion de polimerasa en cadena (pcr) humano en tiempo real.
WO2012088456A2 (en) 2010-12-22 2012-06-28 Natera, Inc. Methods for non-invasive prenatal paternity testing
EP3901955A1 (de) 2011-01-05 2021-10-27 The Chinese University Of Hong Kong Nichtinvasive pränatale genotypisierung fetaler geschlechtschromosomen
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
CA2826748C (en) 2011-02-09 2020-08-04 Bio-Rad Laboratories, Inc. Method of detecting variations in copy number of a target nucleic acid
EP3202921B1 (de) 2011-02-24 2019-02-13 The Chinese University of Hong Kong Molekularer test von mehrlingsschwangerschaften
WO2012123297A1 (en) * 2011-03-11 2012-09-20 Roche Diagnostics Gmbh Nnmt as marker for chronic obstructive pulmonary disease (copd)
CA2826811A1 (en) * 2011-03-11 2012-09-20 F. Hoffmann-La Roche Ag Apex1 as marker for chronic obstructive pulmonary disease (copd)
PL2697392T3 (pl) 2011-04-12 2016-08-31 Verinata Health Inc Rozdzielanie frakcji genomowych z wykorzystaniem liczby polimorfizmów
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
WO2012145399A2 (en) * 2011-04-20 2012-10-26 Traxxsson, Llc Methods of diagnosing cancer in a patient
US20140234860A1 (en) * 2011-04-20 2014-08-21 Traxxsson, Llc Measurement of pka for cancer characterization
CN103717750B (zh) 2011-04-29 2017-03-08 塞昆纳姆股份有限公司 少数核酸物质的定量
US9956281B2 (en) 2011-05-04 2018-05-01 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
CA2742327A1 (en) 2011-05-20 2012-11-20 The University Of British Columiba Systems and methods for enhanced scoda
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
AU2012261664B2 (en) 2011-06-29 2014-07-03 Bgi Genomics Co., Ltd. Noninvasive detection of fetal genetic abnormality
US20140371083A1 (en) 2011-07-14 2014-12-18 Celula, Inc. Systems, apparatus and methods for biochemical analysis
US20130018700A1 (en) * 2011-07-14 2013-01-17 International Business Machines Corporation Optimizing product portfolios under customer choice
US9816996B2 (en) * 2011-07-26 2017-11-14 National Institute Of Advanced Industrial Science And Technology Antibody for detecting epithelial ovarian cancer marker and method for diagnosing epithelial ovarian cancer
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
JP6276992B2 (ja) * 2011-09-15 2018-02-14 国立大学法人名古屋大学 胸膜中皮腫患者の早期発見のための分子マーカー及びその発現解析方法
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2012324532B2 (en) 2011-10-18 2017-11-02 Agilent Technologies, Inc. Fetal chromosomal aneuploidy diagnosis
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
EP3904536A1 (de) 2011-12-09 2021-11-03 Adaptive Biotechnologies Corporation Diagnose von lymphoid-malignität und nachweis minimaler resterkrankungen
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
WO2013104994A2 (en) 2012-01-13 2013-07-18 The University Of British Columbia Multiple arm apparatus and methods for separation of particles
WO2013110007A1 (en) * 2012-01-18 2013-07-25 The Trustees Of Columbia University In The City Of New York USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION
JP6431769B2 (ja) 2012-01-20 2018-11-28 セクエノム, インコーポレイテッド 実験条件を要因として含める診断プロセス
EP2805166B1 (de) * 2012-01-20 2018-11-21 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren zur vorhersage der überlebenszeit eines patienten, der an krebs leidet
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
KR101256206B1 (ko) * 2012-03-02 2013-04-19 의료법인 제일의료재단 태아의 성별 결정을 위한 분석방법 및 장치
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
EP2823060B1 (de) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Festlegung von gepaarten immunrezeptorketten aus frequenzabgestimmten untereinheiten
WO2013134860A1 (en) * 2012-03-16 2013-09-19 University Health Network Cancer biomarkers and methods of use
CN104350158A (zh) 2012-03-26 2015-02-11 约翰霍普金斯大学 快速非整倍性检测
EP2844773B1 (de) 2012-05-04 2017-08-16 Boreal Genomics Corp. Biomarkeranalyse mittels scodaphorese
SG11201407107VA (en) 2012-05-08 2014-11-27 Adaptive Biotechnologies Corp Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
JP2015519565A (ja) * 2012-05-10 2015-07-09 ユートロピクス ファーマシューティカルズ, インコーポレイテッド がんに対する補助的機能診断テスト
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013177206A2 (en) 2012-05-21 2013-11-28 Fluidigm Corporation Single-particle analysis of particle populations
EP2863920B1 (de) 2012-06-20 2023-03-22 Eutropics Pharmaceuticals, Inc. Chinolinderivate zur verwendung in der behanldung von brustkrebs
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014011928A1 (en) 2012-07-13 2014-01-16 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
FR2993668B1 (fr) * 2012-07-17 2015-07-03 Cisbio Bioassays Methode theranostique basee sur la detection de dimeres her2-her2
WO2014015269A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
CN105189779B (zh) 2012-10-01 2018-05-11 适应生物技术公司 通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA3120521A1 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6381033B2 (ja) * 2012-10-12 2018-08-29 国立大学法人弘前大学 前立腺癌と前立腺肥大を識別するための方法およびキット
EP2912466B1 (de) * 2012-10-26 2018-08-29 Institut Gustave Roussy Verfahren zur vorhersage der empfindlichkeit eines subjekts auf therapie mit t-zell aktivierenden antikörpern
WO2014081953A1 (en) 2012-11-21 2014-05-30 Richard David J Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
KR102120510B1 (ko) * 2012-11-28 2020-06-08 넥타르 테라퓨틱스 지속 작용성 토포아이소머라제 i 저해제를 이용하는 유방암 치료의 효능을 평가 및 예측하기 위한 방법
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2759602A1 (de) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Nichtinvasive Verfahren zur pränatalen Gendiagnose
US20140222512A1 (en) * 2013-02-01 2014-08-07 Goodsnitch, Inc. Receiving, tracking and analyzing business intelligence data
CA2900529A1 (en) * 2013-02-08 2014-08-14 Institute For Myeloma & Bone Cancer Research Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma
EP4202441A3 (de) 2013-03-09 2023-07-26 Immunis.AI, Inc. Genexpressionsprofil in makrophagen zur diagnose von krebs
EP3385717A3 (de) 2013-03-09 2018-10-24 Harry Stylli Verfahren zum nachweis von prostatakrebs
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
EP2971126B1 (de) 2013-03-15 2018-11-07 The Chinese University Of Hong Kong Bestimmung fötaler genome für schwangerschaften mit mehreren föten
DK2970958T3 (en) 2013-03-15 2018-02-19 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
GB201304810D0 (en) 2013-03-15 2013-05-01 Isis Innovation Assay
US9340835B2 (en) 2013-03-15 2016-05-17 Boreal Genomics Corp. Method for separating homoduplexed and heteroduplexed nucleic acids
EP4187543A1 (de) 2013-04-03 2023-05-31 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
TWI522367B (zh) * 2013-04-12 2016-02-21 Univ Chang Gung Urine biomarkers are used to predict bladder and kidney cancer
WO2014172390A2 (en) * 2013-04-15 2014-10-23 Cedars-Sinai Medical Center Methods for detecting cancer metastasis
WO2014180910A1 (en) 2013-05-09 2014-11-13 Roche Diagnostics Gmbh Method of determining the fraction of fetal dna in maternal blood using hla markers
US20140343982A1 (en) * 2013-05-14 2014-11-20 Landmark Graphics Corporation Methods and systems related to workflow mentoring
CA2912526C (en) * 2013-05-16 2021-09-14 Kyoto University Method for determining prognosis of cancer
US9725494B2 (en) * 2013-05-17 2017-08-08 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Soluble CD27 (sCD27) and the use thereof
CA2910205C (en) 2013-05-24 2023-04-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014194289A1 (en) * 2013-05-31 2014-12-04 Nektar Therapeutics Method for predicting and evaluating responsiveness to cancer treatment with dna-damaging chemotherapeutic agents
US10622094B2 (en) 2013-06-21 2020-04-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
FR3008096B1 (fr) * 2013-07-03 2015-08-14 Gregory Raux Kit et methode de detection in vitro du rhesus d
EP4136972A1 (de) 2013-07-24 2023-02-22 Streck, Inc. Zusammensetzungen und verfahren zur stabilisierung zirkulierender tumorzellen
WO2015017788A1 (en) 2013-08-01 2015-02-05 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
CA2925528C (en) 2013-10-04 2023-09-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2925111C (en) 2013-10-07 2024-01-16 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
JP6538044B2 (ja) 2013-10-30 2019-07-03 ユートロピクス ファーマシューティカルズ, インコーポレイテッド 化学療法感受性および化学毒性を判定する方法
AU2014346562B2 (en) 2013-11-07 2018-11-29 The Board Of Trustees Of The Leland Stanford Junior University Cell-free nucleic acids for the analysis of the human microbiome and components thereof
EP2876442A1 (de) * 2013-11-22 2015-05-27 Institut de Cancérologie de l'Ouest Olfactomedin-4, Neudesin und Desmoplakin als Biomarker von Brustkrebs
US20160304968A1 (en) * 2013-12-02 2016-10-20 Oncomed Pharmaceuticals, Inc. Identification of Predictive Biomarkers Associated With WNT Pathway Inhibitors
EP3114240B1 (de) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Verfahren unter verwendung von randomerhaltigen synthetischen molekülen
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
US10133996B2 (en) * 2014-04-22 2018-11-20 International Business Machines Corporation Object lifecycle analysis tool
US20160034640A1 (en) 2014-07-30 2016-02-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2016040843A1 (en) 2014-09-11 2016-03-17 Harry Stylli Methods of detecting prostate cancer
EP3212790B1 (de) 2014-10-29 2020-03-25 Adaptive Biotechnologies Corp. Hochmultiplexierter gleichzeitiger nachweis von für adaptive gepaarte immunrezeptorheterodimere codierenden nukleinsäuren aus einer vielzahl von proben
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
JP6774951B2 (ja) 2015-01-12 2020-11-04 ユートロピクス ファーマシューティカルズ, インコーポレイテッド 癌処置をガイドするためのコンテクストに依存する診断試験
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US9901574B2 (en) 2015-04-20 2018-02-27 Tolero Pharmaceuticals, Inc. Predicting response to alvocidib by mitochondrial profiling
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
EP3298021B1 (de) 2015-05-18 2019-05-01 Tolero Pharmaceuticals, Inc. Alvocidib-prodrugs mit erhöhter bioverfügbarkeit
US11130986B2 (en) 2015-05-20 2021-09-28 Quantum-Si Incorporated Method for isolating target nucleic acid using heteroduplex binding proteins
US11111538B2 (en) 2015-05-22 2021-09-07 Nipd Genetics Public Company Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
DE102015111329B4 (de) 2015-07-13 2017-02-02 Bernd-Peter Ernst Verfahren zum Bestimmen einer relativen Häufigkeit von verschiedenen Genen oder Chromosomen eines Genoms in einer Probe
EP3331510A4 (de) 2015-08-03 2019-04-03 Tolero Pharmaceuticals, Inc. Kombinationstherapien zur behandlung von krebs
US11377687B2 (en) 2015-10-16 2022-07-05 Inguran, Llc Methods of genomic evaluation in livestock
CA3000506A1 (en) 2015-10-16 2017-04-20 Inguran, Llc Methods of genomic evaluation in livestock
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
US11698369B2 (en) 2016-01-12 2023-07-11 Oncotracker, Inc. Methods for monitoring immune status of a subject
US11708574B2 (en) 2016-06-10 2023-07-25 Myriad Women's Health, Inc. Nucleic acid sequencing adapters and uses thereof
WO2018002147A1 (en) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Detection of borealin mutations for diagnosing thyroid dysgenesis
EP3491560A1 (de) 2016-07-27 2019-06-05 Sequenom, Inc. Genkopienzahlvariationklassifizierungen
EP3491381A1 (de) 2016-07-29 2019-06-05 Streck, Inc. Suspensionszusammensetzung zur kontrolle einer hämatologischen analyse
US11854666B2 (en) 2016-09-29 2023-12-26 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US11274349B2 (en) 2016-11-08 2022-03-15 Cedars-Sinai Medical Center Methods for diagnosing cancer
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
EP3362471B1 (de) 2016-12-19 2021-11-17 Sumitomo Dainippon Pharma Oncology, Inc. Profilierung von peptiden und verfahren zur sensitivitätsprofilierung
JP7237003B2 (ja) 2017-01-24 2023-03-10 セクエノム, インコーポレイテッド 遺伝子片の評価のための方法およびプロセス
AU2018225348A1 (en) 2017-02-21 2019-07-18 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
EP3602359A4 (de) 2017-03-24 2021-01-06 Myriad Women's Health, Inc. Kopienzahlvariantencaller
US11635435B2 (en) 2017-06-13 2023-04-25 Oncotracker, Inc. Diagnostic, prognostic, and monitoring methods for solid tumor cancers
SK862017A3 (sk) 2017-08-24 2020-05-04 Grendar Marian Doc Mgr Phd Spôsob použitia fetálnej frakcie a chromozómovej reprezentácie pri určovaní aneuploidného stavu v neinvazívnom prenatálnom testovaní
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
WO2019084489A1 (en) 2017-10-27 2019-05-02 Juno Diagnostics, Inc. DEVICES, SYSTEMS AND METHODS FOR ULTRA-LOW VOLUMES LIQUID BIOPSY
WO2019229113A1 (en) 2018-05-30 2019-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Detection of tubb1 mutations for diagnosing thyroid dysgenesis
GB201810571D0 (en) 2018-06-27 2018-08-15 Cs Genetics Ltd Reagents and methods for the analysis of circulating microparticles
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN113490499A (zh) 2018-12-04 2021-10-08 大日本住友制药肿瘤公司 用作治疗癌症的活性剂的cdk9抑制剂及其多晶型物
WO2020191326A1 (en) 2019-03-20 2020-09-24 Sumitomo Dainippon Pharma Oncology, Inc. Treatment of acute myeloid leukemia (aml) with venetoclax failure
GB201909325D0 (en) 2019-06-28 2019-08-14 Cs Genetics Ltd Reagents and methods for analysis for microparticles
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008304A1 (en) 1989-11-24 1991-06-13 Isis Innovation Limited Prenatal genetic determination
WO1995006137A1 (en) * 1993-08-27 1995-03-02 Australian Red Cross Society Detection of genes
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.

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