DE69733663D1 - Analytisches system und verfahren - Google Patents

Analytisches system und verfahren

Info

Publication number
DE69733663D1
DE69733663D1 DE69733663T DE69733663T DE69733663D1 DE 69733663 D1 DE69733663 D1 DE 69733663D1 DE 69733663 T DE69733663 T DE 69733663T DE 69733663 T DE69733663 T DE 69733663T DE 69733663 D1 DE69733663 D1 DE 69733663D1
Authority
DE
Germany
Prior art keywords
analytical system
substrate
reservoirs
fluids
engaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69733663T
Other languages
English (en)
Other versions
DE69733663T2 (de
Inventor
Y Chow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caliper Life Sciences Inc
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24777319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69733663(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Publication of DE69733663D1 publication Critical patent/DE69733663D1/de
Application granted granted Critical
Publication of DE69733663T2 publication Critical patent/DE69733663T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0654Lenses; Optical fibres
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00326Analysers with modular structure
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer
DE69733663T 1996-08-02 1997-07-31 Analytisches system und verfahren Expired - Lifetime DE69733663T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US691632 1996-08-02
US08/691,632 US6399023B1 (en) 1996-04-16 1996-08-02 Analytical system and method
PCT/US1997/013178 WO1998005424A1 (en) 1996-08-02 1997-07-31 Analytical system and method

Publications (2)

Publication Number Publication Date
DE69733663D1 true DE69733663D1 (de) 2005-08-04
DE69733663T2 DE69733663T2 (de) 2006-05-04

Family

ID=24777319

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733663T Expired - Lifetime DE69733663T2 (de) 1996-08-02 1997-07-31 Analytisches system und verfahren

Country Status (11)

Country Link
US (6) US6399023B1 (de)
EP (2) EP1426109A1 (de)
JP (1) JP3686932B2 (de)
CN (1) CN1096297C (de)
AT (1) ATE298631T1 (de)
AU (1) AU717981B2 (de)
CA (1) CA2259929C (de)
DE (1) DE69733663T2 (de)
TW (1) TW350914B (de)
WO (1) WO1998005424A1 (de)
ZA (1) ZA976887B (de)

Families Citing this family (409)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
WO1998000231A1 (en) 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
US6149869A (en) * 1996-10-23 2000-11-21 Glaxo Wellcome Inc. Chemical synthesizers
US6042789A (en) * 1996-10-23 2000-03-28 Glaxo Group Limited System for parallel synthesis of organic compounds
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
GB9705667D0 (en) * 1997-03-19 1997-05-07 Jackson James R Diagnostic and analytical devices
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
CA2284612A1 (en) 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
EP0988529B1 (de) * 1997-04-25 2013-06-12 Caliper Life Sciences, Inc. Mikrofluidische geräte mit verbesserten kanalgeometrien
EP1021566A4 (de) 1997-06-09 2002-06-19 Caliper Techn Corp Vorrichtung und verfahren zum richtigstellen von verschiedenen geschwindigkeitenin mikrofluidischen systemen
US6425972B1 (en) 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US6818110B1 (en) * 1997-09-30 2004-11-16 Symyx Technologies, Inc. Combinatorial electrochemical deposition and testing system
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6444474B1 (en) * 1998-04-22 2002-09-03 Eltron Research, Inc. Microfluidic system for measurement of total organic carbon
US6123798A (en) * 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
WO1999064836A1 (en) * 1998-06-08 1999-12-16 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6366924B1 (en) 1998-07-27 2002-04-02 Caliper Technologies Corp. Distributed database for analytical instruments
US7155344B1 (en) 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6447724B1 (en) 1998-08-11 2002-09-10 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6326612B1 (en) * 1998-10-13 2001-12-04 Texas Instruments Incorporated System and method for optical sensing utilizing a portable, detachable sensor cartridge
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
DE19854096A1 (de) * 1998-11-24 2000-05-25 Merck Patent Gmbh Anschlußträger für plattenförmige Mikrokomponenten
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
EP1135679B1 (de) * 1998-11-30 2009-09-02 Abbott Laboratories Multichemie-messvorrichtung und teststreifen
EP1155435A4 (de) * 1999-01-08 2004-08-11 Univ Northeastern Elektropneumatischer verteiler für zeitmultiplexte analytischemicrosystemen
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
JP4515640B2 (ja) 1999-02-02 2010-08-04 カリパー・ライフ・サイエンシズ・インク. タンパク質特性決定方法、装置及びシステム
AU3372800A (en) 1999-02-23 2000-09-14 Caliper Technologies Corporation Manipulation of microparticles in microfluidic systems
US6239445B1 (en) * 1999-03-01 2001-05-29 Bayer Corporation Optical inspection apparatus with removable inserts
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
CA2367912A1 (en) * 1999-03-19 2000-09-28 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
DE19917433C2 (de) * 1999-04-19 2003-05-22 Fraunhofer Ges Forschung Mikroreaktorsystem zum Erzeugen und Testen von Substanzen und Wirkstoffen
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
WO2002043864A2 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6458259B1 (en) 1999-05-11 2002-10-01 Caliper Technologies Corp. Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
WO2000070080A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
EP1185871A4 (de) 1999-06-01 2003-01-15 Caliper Techn Corp Assays im kleinstformat und mikrofluidische vorrichtungen für aktivitäten von transportern, gradienten und bindungsassays
AU5405100A (en) * 1999-06-16 2001-01-02 Gesellschaft Zur Forderung Der Spektrochemie Und Angewandten Spektroskopie E.V. Device for preparing samples
DE19927534B4 (de) * 1999-06-16 2008-01-31 Merck Patent Gmbh Vorrichtung zur Probenaufgabe
EP1360992A3 (de) * 1999-06-22 2004-05-19 Caliper Life Sciences, Inc. Apparat zur Bedienung eines mikrofluidischen Gerätes
DE19964399B4 (de) * 1999-06-22 2005-06-16 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Einrichtung zum Betrieb eines Labor-Mikrochips mit einem mittels eines Bajonettverschlusses befestigbaren Schnittstellenelement
DE19928412C2 (de) 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
JP2003502655A (ja) * 1999-06-22 2003-01-21 アジレント・テクノロジーズ・インコーポレーテッド 微小流体デバイスの操作用装置
DE19928410C2 (de) * 1999-06-22 2002-11-28 Agilent Technologies Inc Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
DE19964315B4 (de) * 1999-06-22 2005-01-13 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Analyseneinheit mit einem Schnittstellenelement und einem Labor-Mikrochip
US7396444B2 (en) * 1999-06-22 2008-07-08 Agilent Technologies Inc. Device to operate a laboratory microchip
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
AU6068300A (en) 1999-07-06 2001-01-22 Caliper Technologies Corporation Microfluidic systems and methods for determining modulator kinetics
DE19933458B4 (de) * 1999-07-15 2015-08-20 Eppendorf Ag Einrichtungen und Systeme zum Handhaben von Flüssigkeitsproben
EP1072881A3 (de) * 1999-07-30 2002-04-24 Texas Instruments Incorporated Ein integrierter optischer Sensor
US6692697B1 (en) 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
US6495104B1 (en) * 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
AU7101000A (en) 1999-09-10 2001-04-10 Caliper Technologies Corporation Microfabrication methods and devices
US6767440B1 (en) 2001-04-24 2004-07-27 Roche Diagnostics Corporation Biosensor
US6537771B1 (en) 1999-10-08 2003-03-25 Caliper Technologies Corp. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6386014B1 (en) 1999-11-18 2002-05-14 Eagle Research Corporation Energy measurement device for flowing gas using microminiature gas chromatograph
US6271038B1 (en) 1999-12-15 2001-08-07 Glaxo Wellcome Inc. Methods for high throughout determination and ranking of formulations and solubility
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
JP2004530860A (ja) * 2000-01-11 2004-10-07 クリニカル・マイクロ・センサーズ・インコーポレイテッド バイオチップ多重化デバイスおよび方法
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US6556923B2 (en) * 2000-01-26 2003-04-29 Caliper Technologies Corp. Software for high throughput microfluidic systems
TWI225494B (en) 2000-02-17 2004-12-21 Mitsui Chemicals Inc Microcellular polyurethane elastomer, and method of producing the same
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
CN1444646A (zh) 2000-02-23 2003-09-24 齐翁米克斯股份有限公司 具有凸起的样品表面的芯片
BR0109125A (pt) * 2000-03-09 2002-11-26 Clinical Analysis Corp Sistema de diagnóstico médico
US6749735B1 (en) 2000-03-16 2004-06-15 David Le Febre Electromobility focusing controlled channel electrophoresis system
US7141152B2 (en) * 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
EP1281002A4 (de) 2000-05-11 2006-08-09 Caliper Life Sciences Inc Mikrofluidische einrichtungen und methoden zur beeinflussung des strömungswiderstandes und elektrischen widerstandes mit hilfe von viskositätssteigernden zusätzen
AU6152301A (en) * 2000-05-12 2001-11-26 Caliper Techn Corp Detection of nucleic acid hybridization by fluorescence polarization
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
EP1161985B1 (de) * 2000-06-05 2005-10-26 STMicroelectronics S.r.l. Verfahren zur Herstellung integrierter chemischer Mikroreaktoren aus Halbleitermaterial sowie integrierter Mikroreaktor
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US6632400B1 (en) * 2000-06-22 2003-10-14 Agilent Technologies, Inc. Integrated microfluidic and electronic components
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US20070119711A1 (en) * 2000-08-02 2007-05-31 Caliper Life Sciences, Inc. High throughput separations based analysis systems and methods
CN100394171C (zh) * 2000-08-02 2008-06-11 卡钳技术有限公司 基于分离的高处理量分析系统
US7192559B2 (en) 2000-08-03 2007-03-20 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
US20020142618A1 (en) 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US6581020B1 (en) * 2000-10-10 2003-06-17 Velquest Corporation Process-linked data management system
JP2004513342A (ja) 2000-10-31 2004-04-30 カリパー・テクノロジーズ・コープ. 現場で材料を濃縮するミクロ流体方法、装置及びシステム
US20030057092A1 (en) * 2000-10-31 2003-03-27 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20050011761A1 (en) * 2000-10-31 2005-01-20 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US6878755B2 (en) * 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
EP1355823A4 (de) * 2001-01-29 2005-04-20 Caliper Life Sciences Inc Nichtmechanische ventile für strömungssysteme
US6613284B2 (en) * 2001-02-01 2003-09-02 V&P Scientific, Inc. Microarrayer
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7670559B2 (en) 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
WO2002103323A2 (en) * 2001-02-15 2002-12-27 Caliper Technologies Corp. Microfluidic systems with enhanced detection systems
US6720148B1 (en) 2001-02-22 2004-04-13 Caliper Life Sciences, Inc. Methods and systems for identifying nucleotides by primer extension
US7867776B2 (en) * 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
US20060108218A1 (en) * 2001-03-05 2006-05-25 Clinical Analysis Corporation Test cell for use with medical diagnostic instrument
US7223363B2 (en) * 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
US6852287B2 (en) * 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6727479B2 (en) * 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US7294478B1 (en) * 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
US6381516B1 (en) * 2001-06-16 2002-04-30 Data I/O Corporation Modular off-line micro device processing system
US20030077570A1 (en) * 2001-09-20 2003-04-24 Coventor, Inc. Small molecule substrate based enzyme activity assays
ATE465811T1 (de) * 2001-07-13 2010-05-15 Caliper Life Sciences Inc Methode zur trennung von komponenten eines gemisches
US6825127B2 (en) 2001-07-24 2004-11-30 Zarlink Semiconductor Inc. Micro-fluidic devices
US7060171B1 (en) * 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
WO2003015890A1 (en) * 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
US20030062833A1 (en) * 2001-10-03 2003-04-03 Wen-Yen Tai Mini-type decorative bulb capable of emitting light through entire circumferential face
WO2003035671A2 (en) * 2001-10-24 2003-05-01 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
DE10203211A1 (de) * 2002-01-28 2003-08-14 Siemens Ag Mikrofluidikprobenmodul mit Mitteln zur Temperaturbeeinflussung
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
EP2581739B1 (de) 2002-03-05 2015-11-04 Caliper Life Sciences, Inc. Mikrofluidisches Trennverfahren mit kombinierter Druck- und Spannungsregelung
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US7252928B1 (en) 2002-03-12 2007-08-07 Caliper Life Sciences, Inc. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
EP1490292A1 (de) * 2002-03-31 2004-12-29 Gyros AB Effiziente mikrofluidvorrichtungen
AU2003228395B2 (en) * 2002-04-02 2006-12-21 Caliper Life Sciences, Inc. Methods and apparatus for separation and isolation of components from a biological sample
US20030203504A1 (en) * 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
EP1385006A3 (de) * 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag System und Patrone zur Verarbeitung einer biologischen Probe
US7803322B2 (en) * 2002-08-14 2010-09-28 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
US7267799B1 (en) 2002-08-14 2007-09-11 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
DE60321376D1 (de) * 2002-12-04 2008-07-10 Spinx Inc Vorrichtungen und verfahren zur programmierbaren mikrohandhabung von fluiden
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7507376B2 (en) * 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US7682565B2 (en) * 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20040175821A1 (en) * 2003-03-07 2004-09-09 Ehman Michael F. Integrated photodetector for heavy metals and biological activity analysis
EP1473085B1 (de) * 2003-03-31 2015-07-22 Canon Kabushiki Kaisha Behälter für biochemische Reaktionen
EP1473084B1 (de) * 2003-03-31 2015-07-29 Canon Kabushiki Kaisha Behälter für biochemische Reaktionen
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
US20040265184A1 (en) * 2003-04-18 2004-12-30 Kyocera Corporation Microchemical chip and method for producing the same
DE10320957A1 (de) * 2003-05-09 2004-12-09 Evotec Technologies Gmbh Andockeinrichtung für ein fluidisches Mikrossystem
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7118713B2 (en) * 2003-06-03 2006-10-10 Bayer Healthcare Llc Tray assembly for optical inspection apparatus
US20040248306A1 (en) * 2003-06-09 2004-12-09 Hernandez Juan J. Microfluidic water analytical device
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
JP2005030847A (ja) * 2003-07-10 2005-02-03 Sysmex Corp 電子機器および分析システム
JP4228808B2 (ja) * 2003-07-23 2009-02-25 株式会社日立製作所 マイクロ分光計測装置及びマイクロ化学システム
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US20050037508A1 (en) * 2003-08-12 2005-02-17 Juan Hernandez Microfluidic titration apparatus
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
CA2479452C (en) * 2003-08-30 2008-11-04 F.Hoffmann-La Roche Ag Method and device for determining analytes in a liquid
US7431883B2 (en) * 2003-09-30 2008-10-07 Beckman Coulter, Inc. Clinical analysis system
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7718133B2 (en) * 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
CN101914803B (zh) * 2004-01-25 2012-07-04 弗卢丁公司 晶体形成设备与系统以及制造和使用该晶体形成设备与系统的方法
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
CN102357352B (zh) 2004-01-26 2015-08-12 哈佛大学 流体递送系统和方法
EP1561507A1 (de) * 2004-01-27 2005-08-10 Future Diagnostics B.V. System für das Kennzeichnen einer Flüssigkeit, microfluidische Vorrichtung für das Kennzeichnen oder das Analysieren der Bestandteile einer Konzentration, eine Methode des Kennzeichnens oder des Analysierens solcher Konzentrationen und einer Messvorrichtung
WO2005078118A1 (en) 2004-02-06 2005-08-25 Bayer Healthcare Llc Oxidizable species as an internal reference for biosensors and method of use
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
KR100534615B1 (ko) * 2004-03-15 2005-12-07 삼성전자주식회사 접철가능한 급지카세트를 구비한 화상형성장치
US20070071641A1 (en) * 2004-04-09 2007-03-29 Brock David A Tray assembly for optical inspection apparatus
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7984443B2 (en) 2004-07-22 2011-07-19 Computer Associates Think, Inc. System and method for normalizing job properties
US7932090B2 (en) * 2004-08-05 2011-04-26 3M Innovative Properties Company Sample processing device positioning apparatus and methods
KR100579831B1 (ko) * 2004-09-07 2006-05-15 삼성전자주식회사 조립 가능한 미세유동형 바이오시료 처리장치
JP4506375B2 (ja) * 2004-09-22 2010-07-21 ウシオ電機株式会社 吸光度測定ユニット
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
AU2005290314A1 (en) * 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
US7727477B2 (en) * 2004-12-10 2010-06-01 Bio-Rad Laboratories, Inc. Apparatus for priming microfluidics devices with feedback control
US7582263B2 (en) * 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP1880223A2 (de) 2005-04-21 2008-01-23 Celerus Diagnostics, Inc. Verfahren und vorrichtung zur automatisierten schnellen immunhistochemie
JP2006322720A (ja) * 2005-05-17 2006-11-30 Ushio Inc マイクロチップ吸光光度測定装置
JP4635728B2 (ja) * 2005-06-03 2011-02-23 ウシオ電機株式会社 マイクロチップ検査装置
US7323660B2 (en) * 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
AU2006272909B2 (en) 2005-07-20 2013-02-07 Bayer Healthcare Llc Gated amperometry
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8480053B2 (en) * 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
JP2007114189A (ja) * 2005-09-20 2007-05-10 Yamaha Corp マイクロ化学チップ用温度制御装置
ES2379921T3 (es) * 2005-09-29 2012-05-07 Siemens Medical Solutions Usa, Inc. Chip microfluídico que puede sintetizar moléculas marcadas radiactivamente en una escala adecuada para la obtención de imágenes en seres humanos con tomografía por emisión de positrones
AU2006297572B2 (en) 2005-09-30 2012-11-15 Ascensia Diabetes Care Holdings Ag Gated Voltammetry
US7727371B2 (en) * 2005-10-07 2010-06-01 Caliper Life Sciences, Inc. Electrode apparatus for use with a microfluidic device
WO2007044888A2 (en) * 2005-10-11 2007-04-19 The Johns Hopkins Univerisity Microfluidic device and method for high-throughput cellular gradient and dose response studies
EP1945815A4 (de) * 2005-10-11 2009-02-18 Handylab Inc Polynukleotidprobenvorbereitungsvorrichtung
WO2007044856A1 (en) * 2005-10-11 2007-04-19 The Johns Hopkins University Device and method for high-throughput stimulation, immunostaining, and visualization of single cells
JP2007147456A (ja) * 2005-11-28 2007-06-14 Seiko Epson Corp マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法
US20070258864A1 (en) * 2005-12-08 2007-11-08 Protein Discovery, Inc. Methods and devices for concentration and fractionation of analytes for chemical analysis
JP2009521684A (ja) * 2005-12-22 2009-06-04 ハネウェル・インターナショナル・インコーポレーテッド 携帯用サンプル分析装置のカートリッジ
EP1983339A4 (de) * 2006-01-22 2010-02-17 Arkray Inc Analysevorrichtung mit abwurfmechanismus
EP1815785A1 (de) * 2006-02-02 2007-08-08 Bioception B.V.i.o. Diagnosegerät in Form einer Kassette zur Diagnose von Flüssigkeit und deren Inhalt
US7862000B2 (en) * 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
WO2007112114A2 (en) 2006-03-24 2007-10-04 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2550004T3 (es) 2006-04-04 2015-11-03 Singulex, Inc. Sistema de alta sensibilidad y métodos de análisis de la troponina
EP3156799B1 (de) 2006-04-04 2024-01-24 Novilux, LLC Analysator und verfahren zur hochempfindlichen detektion von analyten
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
WO2007115378A1 (en) * 2006-04-11 2007-10-18 Minifab (Australia) Pty Ltd Microfluidic package housing
WO2010027894A2 (en) * 2008-08-27 2010-03-11 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
JP4292279B2 (ja) * 2006-07-18 2009-07-08 ファルマ・アクセス株式会社 結晶作製器具
JP4912096B2 (ja) * 2006-09-07 2012-04-04 ローム株式会社 マイクロチップ検査装置
US20080131327A1 (en) * 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
EP2091647A2 (de) 2006-11-14 2009-08-26 Handylab, Inc. Mikrofluidisches system für parallele amplifikation und erkennung von polynukleotiden
EA201201363A1 (ru) 2006-11-21 2013-08-30 Медимейт Холдинг Б.В. Датчик ионов для текучей среды и способ его изготовления
WO2008091694A2 (en) * 2007-01-23 2008-07-31 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US7799656B2 (en) 2007-03-15 2010-09-21 Dalsa Semiconductor Inc. Microchannels for BioMEMS devices
US8071035B2 (en) * 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
ES2687620T3 (es) 2007-05-04 2018-10-26 Opko Diagnostics, Llc Dispositivo y método para análisis en sistemas microfluídicos
US9121843B2 (en) 2007-05-08 2015-09-01 Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
CA2685361C (en) * 2007-05-18 2014-05-06 Medimate Holding B.V. Test chip with plug for measuring the concentration of an analyte in a liquid, housing for test chip and socket for plug
EP2562537B1 (de) * 2007-05-18 2016-07-13 CE-Mate B.V. Probenanalysemethode und -gerät mit Testchip und Handhabungseinheit
US8522413B2 (en) * 2007-06-26 2013-09-03 Micronit Microfluids B.V. Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof
EP2008716A1 (de) * 2007-06-28 2008-12-31 Bp Oil International Limited Probenplatte
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8324372B2 (en) 2007-07-13 2012-12-04 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
CN104307581B (zh) * 2007-08-09 2017-04-12 诺思可有限公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
WO2009046227A1 (en) 2007-10-02 2009-04-09 Theranos, Inc. Modular point-of-care devices and uses thereof
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
WO2009117033A2 (en) 2007-12-19 2009-09-24 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
CN102016552A (zh) * 2008-03-05 2011-04-13 神谷来克斯公司 用于分子的高灵敏性检测的方法和组合物
US7919062B2 (en) * 2008-03-20 2011-04-05 Corning Incorporated Modular microfluidic system and method for building a modular microfludic system
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
US8222049B2 (en) 2008-04-25 2012-07-17 Opko Diagnostics, Llc Flow control in microfluidic systems
CN101625996B (zh) * 2008-07-08 2011-03-23 中芯国际集成电路制造(上海)有限公司 用以减少暗电流的ono侧墙刻蚀工艺
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US20100009351A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
DE202008009938U1 (de) 2008-07-23 2008-10-09 Bürkert Werke GmbH & Co.KG Sensorsystem
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
GB2465842A (en) * 2008-12-05 2010-06-09 Accunostics Ltd Adaptor for an analyte measuring device
EP2376226B1 (de) 2008-12-18 2018-09-12 Opko Diagnostics, LLC Verbesserte reagentienlagerung in mikrofluidsystemen und verwandte artikel und verfahren
US7927904B2 (en) 2009-01-05 2011-04-19 Dalsa Semiconductor Inc. Method of making BIOMEMS devices
EP2391451B1 (de) * 2009-02-02 2018-09-12 Opko Diagnostics, LLC Strukturen zur steuerung von lichtwechselwirkung mit mikrofluidikvorrichtungen
US8354080B2 (en) * 2009-04-10 2013-01-15 Canon U.S. Life Sciences, Inc. Fluid interface cartridge for a microfluidic chip
CN102439398A (zh) * 2009-04-27 2012-05-02 蛋白质发现公司 可编程电泳凹口过滤器系统及方法
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
AU2010259022B2 (en) * 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
EP2483680A4 (de) 2009-09-30 2014-01-01 Quantapore Inc Ultraschnelle sequenzierung biologischer polymere mithilfe einer markierten nanopore
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
CN102713720B (zh) 2009-10-28 2016-05-11 阿兰蒂克微科学股份有限公司 显微成像装置和显微成像方法
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
PL2504105T3 (pl) 2009-11-24 2021-06-28 Opko Diagnostics, Llc Mieszanie i dostarczanie płynów w układach mikroprzepływowych
AU2011221244B2 (en) 2010-02-23 2014-02-13 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
CN102939160B (zh) 2010-04-16 2016-10-12 欧普科诊断有限责任公司 用于样本分析的系统和装置
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
WO2011140484A1 (en) 2010-05-06 2011-11-10 Singulex, Inc Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
JP5426476B2 (ja) * 2010-05-21 2014-02-26 株式会社エンプラス 分析用具及びマイクロ分析システム
US20130109080A1 (en) * 2010-05-27 2013-05-02 3M Innovative Properties Company Integrated systems and assemblies for sample processing
GB2483858A (en) * 2010-09-21 2012-03-28 Univ Hull Amplifying nucleic acids using microfluidic device to perform PRC
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
CA3097861A1 (en) 2011-01-21 2012-07-26 Labrador Diagnostics Llc Systems and methods for sample use maximization
FR2973720B1 (fr) 2011-04-08 2016-02-26 Commissariat Energie Atomique Dispositif de connexion d'une carte microfluidique
WO2012142516A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermo-cycler and methods for synchronized thermocycling and scanning optical detection
WO2012158988A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for valving on a sample processing device
CN103547370A (zh) 2011-05-18 2014-01-29 3M创新有限公司 用于样品处理装置上体积计量的系统和方法
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
WO2013033726A1 (en) * 2011-09-02 2013-03-07 Quinonez Carlo Joseph Universal hardware platform and toolset for operating and fabricating microfluidic devices
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
ES2825905T3 (es) 2011-09-30 2021-05-17 Becton Dickinson Co Tira reactiva unificada
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
TWI638277B (zh) 2012-03-05 2018-10-11 Opko診斷法有限責任公司 用於確定前列腺癌相關事件之機率之分析系統及方法
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9675973B2 (en) * 2012-06-14 2017-06-13 Paratus Diagnostics, LLC Specimen delivery apparatus
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628115S (de) 2012-10-24 2019-04-01
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
TW201422817A (zh) * 2012-12-14 2014-06-16 Ardic Instr Co 生物感測晶片結構
JP2014132228A (ja) * 2013-01-04 2014-07-17 Sony Corp 液体注入用治具セット
EP3450984B1 (de) * 2013-01-31 2020-10-07 Luminex Corporation Flüssigkeitsretentionsplatten und analysepatronen
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
WO2014158367A1 (en) 2013-03-13 2014-10-02 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
WO2014150905A2 (en) 2013-03-15 2014-09-25 Genmark Diagnostics, Inc. Systems, methods, and apparatus for manipulating deformable fluid vessels
JP2013156268A (ja) * 2013-03-28 2013-08-15 Medimate Holding B V 液体で満たされてシールされたチャネルを有する測定試料ハンドリング・デバイス
US9671368B2 (en) * 2013-05-10 2017-06-06 The Regents Of The University Of California Two-dimensional microfluidic devices and methods of using the same
CA2910019A1 (en) 2013-05-24 2014-11-27 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed fret detection
EP3014330B1 (de) 2013-06-26 2024-01-03 Alentic Microscience Inc. Verbesserungen zur probenverarbeitung für mikroskopie
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
WO2015085262A1 (en) * 2013-12-05 2015-06-11 The General Hospital Corporation Modular instrumentation for analyzing biological fluids
US10258991B2 (en) 2014-02-14 2019-04-16 Elements S.R.L. High sensitivity multichannel detection device
DE202015009494U1 (de) 2014-04-10 2018-02-08 10X Genomics, Inc. Fluidische Vorrichtungen und Systeme zur Einkapselung und Partitionierung von Reagenzien, und deren Anwendungen
WO2016027782A1 (ja) * 2014-08-20 2016-02-25 株式会社シン・コーポレイション 検査用装置
EP3204519B1 (de) 2014-10-10 2020-04-29 Quantapore Inc. Analyse nanoporenbasierter polymere mit gegenseitig löschenden fluoreszenzmarkern
CA2964790C (en) 2014-10-24 2023-02-21 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
WO2016062788A1 (en) 2014-10-24 2016-04-28 Ait Austrian Institute Of Technology Gmbh Microfluidic chip for biological analysis
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
JP6929773B2 (ja) 2014-12-12 2021-09-01 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーOpko Diagnostics,Llc 成形によって形成される流体システムを含む培養チャネルを備える流体システム
CN105772117A (zh) * 2014-12-22 2016-07-20 卡梅德生物科技(天津)有限公司 一种用于生物实验室检测化学成份的实验芯片
CN107001026A (zh) * 2015-01-30 2017-08-01 惠普发展公司,有限责任合伙企业 微流体感测系统
US9739751B2 (en) * 2015-02-05 2017-08-22 International Business Machines Corporation Devices for trapping and controlling microparticles with radiation
WO2016149639A1 (en) * 2015-03-19 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
WO2016163946A1 (en) 2015-04-07 2016-10-13 Cell Id Pte Ltd A dc heater
EP3093656A1 (de) 2015-05-13 2016-11-16 ARKRAY, Inc. Analytisches werkzeug und analytisches system
WO2016209734A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Device for analyzing a fluid sample and use of test card with same
US10519493B2 (en) 2015-06-22 2019-12-31 Fluxergy, Llc Apparatus and method for image analysis of a fluid sample undergoing a polymerase chain reaction (PCR)
WO2016209731A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Test card for assay and method of manufacturing same
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US10184102B2 (en) * 2015-08-26 2019-01-22 EMULATE, Inc. Controlling pressure
WO2017044527A1 (en) * 2015-09-09 2017-03-16 Life Technologies Corporation Clamp devices for receiving a cartridge and methods for using same
JP6714603B2 (ja) * 2015-10-09 2020-07-01 シスメックス株式会社 検体処理チップ、検体処理装置および検体処理方法
WO2017100457A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation samples and/or reagents
GB2547753B (en) * 2015-12-28 2020-07-08 Ibm Operation of diagnostic devices involving microchannels and electrodes
US10444184B2 (en) 2015-12-28 2019-10-15 International Business Machines Corporation Operation of diagnostic devices involving microchannels and electrodes
US10088468B2 (en) * 2016-02-04 2018-10-02 Nova Biomedical Corporation Analyte system and method for determining hemoglobin parameters in whole blood
US11446671B2 (en) 2016-03-29 2022-09-20 Leica Microsystems Cms Gmbh Self-contained slide processing unit for biological specimens
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
EP3482196B1 (de) 2016-07-05 2022-02-23 Quantapore, Inc. Optisch basierte nanoporensequenzierung
EP3615220A4 (de) 2017-04-28 2020-12-30 Neofluidics, LLC Fluidische vorrichtungen mit reaktionsvertiefungen und ihre verwendungen
US11745181B2 (en) 2017-08-09 2023-09-05 Unchained Labs Devices and methods for bioassay
WO2019063959A1 (en) * 2017-09-28 2019-04-04 Oxford Nanopore Technologies Limited KIT OF FIRST AND SECOND PARTS DESIGNED TO BE CONNECTED TO ONE ANOTHER
US11305279B2 (en) * 2017-11-10 2022-04-19 Neofluidics, Llc Integrated fluidic circuit and device for droplet manipulation and methods thereof
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
CN112261975B (zh) * 2018-04-11 2022-09-13 印第安纳大学理事会 用于质谱分析的盒、系统和方法
WO2020009896A1 (en) * 2018-07-06 2020-01-09 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor
KR102185961B1 (ko) * 2018-07-11 2020-12-03 부산대학교 산학협력단 교류 전위 변조를 이용한 마이크로 플루이딕 채널 기반의 진단 키트
US11484881B2 (en) 2019-06-27 2022-11-01 Axbio Inc. Biomolecule diagnostic systems
USD1016324S1 (en) * 2020-07-08 2024-02-27 NanoCav, LLC Biological cell processing chip
DE102020128003A1 (de) * 2020-10-23 2020-12-31 Bmg Labtech Gmbh Mikroplatten-Lesegerät
USD983405S1 (en) * 2021-04-15 2023-04-11 Cytoaurora Biotechnologies, Inc. Microfluidic chip

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS533674B2 (de) 1972-11-29 1978-02-08
EP0006031B1 (de) 1978-06-05 1983-06-22 EASTMAN KODAK COMPANY (a New Jersey corporation) Vorrichtung zur Aufnahme von Magazinen und dafür geeignete Magazine
US4170737A (en) * 1978-07-06 1979-10-09 Spetsialnoe Konstruktorskoe Bjuro Biologicheskogo Priborotroenia Akademii Nauk SSSR Top-entry transmission electron microscope
DE3688142T2 (de) 1985-01-25 1993-07-22 Mallinckrodt Sensor Syst Geraet zum nachweis oder zur messung von chemischen komponenten.
JPS61198041A (ja) 1985-02-28 1986-09-02 Konishiroku Photo Ind Co Ltd 生化学分析装置
DE3784161T2 (de) 1986-09-16 1993-05-27 Mitsubishi Corp Automatischer analysator.
US5004582A (en) 1987-07-15 1991-04-02 Fuji Photo Film Co., Ltd. Biochemical analysis apparatus
JPS6480864A (en) 1987-09-24 1989-03-27 Fuji Photo Film Co Ltd Biochemical analyzer
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5106758A (en) * 1988-12-12 1992-04-21 Technicon Instruments Corporation Analytical test device and the use thereof
JP2779676B2 (ja) 1989-06-14 1998-07-23 横河電機株式会社 クロマトグラフィ装置及び成分分離手段の形成方法
JPH03101752A (ja) 1989-09-16 1991-04-26 Canon Inc 画像形成装置
US5219526A (en) 1990-04-27 1993-06-15 Pb Diagnostic Systems Inc. Assay cartridge
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
JP2543243B2 (ja) 1990-09-05 1996-10-16 株式会社京都第一科学 検体自動分析装置
CA2044929C (en) 1991-06-18 1997-11-18 Maxime Ferris Teaching method and system
FR2679661B1 (fr) 1991-07-26 1994-10-14 Sfri Appareil d'analyse automatique d'echantillons.
AU4047493A (en) * 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
JP2745091B2 (ja) 1992-04-03 1998-04-28 東亞医用電子株式会社 免疫凝集測定装置
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5232667A (en) * 1992-05-21 1993-08-03 Diametrics Medical, Inc. Temperature control for portable diagnostic system using a non-contact temperature probe
US5334349A (en) 1992-07-16 1994-08-02 Schiapparelli Biosystems, Inc. Liquid transfer module for a chemical analyzer
US5302348A (en) * 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
US5510082A (en) 1993-01-25 1996-04-23 Fuji Photo Film Co., Ltd. Chemical analysis film supplier
JPH06265447A (ja) 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
US5534328A (en) * 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
DE59408870D1 (de) 1993-04-23 1999-12-09 Roche Diagnostics Gmbh System zur Bevorratung und Zurverfügungstellung von Testelementen
AU7245094A (en) 1993-07-07 1995-02-06 Abaxis, Inc. System and method for incorporating analytical instruments within personal computers
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
AU705351B2 (en) * 1994-11-10 1999-05-20 Orchid Biosciences, Inc. Liquid distribution system
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CA2181190C (en) 1994-11-14 2001-02-06 Peter Wilding Mesoscale sample preparation device and systems for determination and processing of analytes
US5728352A (en) * 1994-11-14 1998-03-17 Advanced Care Products Disposable electronic diagnostic instrument
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5833924A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay device and interface system
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
ES2141460T3 (es) * 1996-04-18 2000-03-16 Alusuisse Lonza Services Ag Superficies de aluminio con colores de interferencia.
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices

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US6432720B2 (en) 2002-08-13
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US5955028A (en) 1999-09-21
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US6071478A (en) 2000-06-06
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CA2259929A1 (en) 1998-02-12
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US6399023B1 (en) 2002-06-04

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