DE69716414T2 - Benzoxazine zur erhöhung der synaptischen reaktionen - Google Patents

Benzoxazine zur erhöhung der synaptischen reaktionen

Info

Publication number
DE69716414T2
DE69716414T2 DE69716414T DE69716414T DE69716414T2 DE 69716414 T2 DE69716414 T2 DE 69716414T2 DE 69716414 T DE69716414 T DE 69716414T DE 69716414 T DE69716414 T DE 69716414T DE 69716414 T2 DE69716414 T2 DE 69716414T2
Authority
DE
Germany
Prior art keywords
compounds
subjects
ampa receptors
benzoxazine
reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69716414T
Other languages
English (en)
Other versions
DE69716414D1 (de
Inventor
A Rogers
S Lynch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69716414D1 publication Critical patent/DE69716414D1/de
Publication of DE69716414T2 publication Critical patent/DE69716414T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
DE69716414T 1996-04-03 1997-03-28 Benzoxazine zur erhöhung der synaptischen reaktionen Expired - Lifetime DE69716414T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/624,335 US5736543A (en) 1996-04-03 1996-04-03 Benzoxazines for enhancing synaptic response
PCT/US1997/005184 WO1997036907A1 (en) 1996-04-03 1997-03-28 Benzoxazines for enhancing synaptic response

Publications (2)

Publication Number Publication Date
DE69716414D1 DE69716414D1 (de) 2002-11-21
DE69716414T2 true DE69716414T2 (de) 2003-06-12

Family

ID=24501596

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69716414T Expired - Lifetime DE69716414T2 (de) 1996-04-03 1997-03-28 Benzoxazine zur erhöhung der synaptischen reaktionen

Country Status (10)

Country Link
US (2) US5736543A (de)
EP (1) EP0891365B1 (de)
JP (1) JP3170294B2 (de)
AT (1) ATE226206T1 (de)
AU (1) AU708212B2 (de)
DE (1) DE69716414T2 (de)
DK (1) DK0891365T3 (de)
ES (1) ES2185932T3 (de)
NZ (1) NZ331992A (de)
WO (1) WO1997036907A1 (de)

Families Citing this family (36)

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AU721936B2 (en) * 1996-04-03 2000-07-20 Regents Of The University Of California, The Benzoxazines for enhancing synaptic response
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
PT1026950E (pt) * 1997-10-27 2006-06-30 Cortex Pharma Inc Tratamento da esquizofrenia com ampaquinas e neurolepticos
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
US6943159B1 (en) 1998-02-18 2005-09-13 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators
US6124278A (en) * 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response
US6011991A (en) * 1998-12-07 2000-01-04 Technology Patents, Llc Communication system and method including brain wave analysis and/or use of brain activity
US7455836B2 (en) * 2000-05-08 2008-11-25 The University Of Melbourne Method of treatment and agents useful for same
TWI232863B (en) 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
KR100864267B1 (ko) * 2001-06-14 2008-10-20 엔.브이.오가논 ＡＭＰＡ 수용체의 양성 조절제로서의(피리도/티에노)-[ｆ]-옥사제핀-5-온 유도체
SK2292004A3 (en) * 2001-11-26 2004-09-08 Cortex Pharma Inc Carbonyl benzoxazine compounds for enhancement of glutamatergic synaptic responses
RS20050202A (en) 2002-09-09 2007-08-03 Nektar Therapeuticals Al.Corporation, Water-soluble polymer alkanals
EA200501117A1 (ru) 2003-01-13 2006-02-24 Кортекс Фармасеутикалс, Инк. Способ лечения снижения когнитивной способности вследствие лишения сна и стресса
US20060063707A1 (en) * 2004-09-17 2006-03-23 Lifelike Biomatic, Inc. Compositions for enhancing memory and methods therefor
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
EP2083921A2 (de) 2006-09-04 2009-08-05 Neurosearch A/S Pharmazeutische kombinationen aus einem nikotinrezeptormodulator und einem mittel zur intensivierung kognitiver funktionen
JP5139446B2 (ja) * 2007-01-03 2013-02-06 レ ラボラトワール セルヴィエ グルタミン酸作動性シナプス応答を増強する３−置換−［１，２，３］−ベンゾトリアジノン化合物
AP2009004915A0 (en) * 2007-01-03 2009-08-31 Cortex Pharma Inc 3-substituted-[1,2,3] benzotriazinone compounds for enhancing glutamatergic synaptic responses
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
MX2009009937A (es) * 2007-03-23 2009-09-24 Univ California Tratamiento de la disfuncion sexual femenina mediante compuestos que modulan de manera positiva los receptores de glutamato tipo ampa.
ES2657054T3 (es) * 2007-05-17 2018-03-01 Respirerx Pharmaceuticals Inc. Amidas disustituidas para mejorar las respuestas sinápticas glutamatérgicas
US8168632B2 (en) * 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
WO2009023126A2 (en) 2007-08-10 2009-02-19 Cortex Pharmaceuticals, Inc. Bicyclic amides for enhancing glutamatergic synaptic responses
US8071914B2 (en) 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
WO2010054336A2 (en) * 2008-11-10 2010-05-14 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
EP2544688B1 (de) 2010-03-02 2016-09-07 President and Fellows of Harvard College Verfahren und zusammensetzungen zur behandlung des angelman-syndroms
WO2012121971A2 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
US10555916B2 (en) 2013-01-25 2020-02-11 Case Western Reserve University NMDAR antagonist for the treatment of pervasive development disorders
MX2015017253A (es) 2013-06-13 2016-04-19 Veroscience Llc Composiciones y metodos para tratar trastornos metabolicos.
CN107286114B (zh) 2016-04-13 2020-08-18 中国人民解放军军事医学科学院毒物药物研究所 Ampa受体增效剂的脑靶向前药及其医药用途
WO2019060298A1 (en) 2017-09-19 2019-03-28 Neuroenhancement Lab, LLC METHOD AND APPARATUS FOR NEURO-ACTIVATION
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
WO2020056418A1 (en) 2018-09-14 2020-03-19 Neuroenhancement Lab, LLC System and method of improving sleep
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3257396A (en) * 1962-06-11 1966-06-21 Geigy Chem Corp Certain 1, 3-benzoxazinone derivatives
ATE253909T1 (de) * 1992-07-24 2003-11-15 Univ California Arzneimittel die den durch ampa rezeptoren vermittelten synaptischen response erhöhen
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response

Also Published As

Publication number Publication date
DK0891365T3 (da) 2003-02-10
ATE226206T1 (de) 2002-11-15
JP3170294B2 (ja) 2001-05-28
US5736543A (en) 1998-04-07
EP0891365B1 (de) 2002-10-16
ES2185932T3 (es) 2003-05-01
EP0891365A1 (de) 1999-01-20
US5962447A (en) 1999-10-05
AU2427497A (en) 1997-10-22
AU708212B2 (en) 1999-07-29
NZ331992A (en) 1999-02-25
JP2000503664A (ja) 2000-03-28
DE69716414D1 (de) 2002-11-21
WO1997036907A1 (en) 1997-10-09

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Publication Publication Date Title
DE69716414D1 (de) Benzoxazine zur erhöhung der synaptischen reaktionen
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CA2138533A1 (en) Drugs that enhance synaptic responses mediated by ampa receptors
PL341427A1 (en) Benzoxazinic compounds for enhancing sybaptic response
DK1355669T3 (da) Forbedret kognitiv træning
DE69834590D1 (de) Benzofurazanderivate und deren verwendung zur verbesserung glutaminerger synaptischer antworten
DE69910552D1 (de) Acylbenzoxazine zur erhöhung der synaptischen reaktion(en)
EA200400584A1 (ru) Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов
CA2249654A1 (en) Benzoxazines for enhancing synaptic response

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee
8370 Indication related to discontinuation of the patent is to be deleted