DE69709377D1 - Mikrofliesssystem für die teilchenanalyse und trennung - Google Patents

Mikrofliesssystem für die teilchenanalyse und trennung

Info

Publication number
DE69709377D1
DE69709377D1 DE69709377T DE69709377T DE69709377D1 DE 69709377 D1 DE69709377 D1 DE 69709377D1 DE 69709377 T DE69709377 T DE 69709377T DE 69709377 T DE69709377 T DE 69709377T DE 69709377 D1 DE69709377 D1 DE 69709377D1
Authority
DE
Germany
Prior art keywords
flow channel
fluid
flow
particles
field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69709377T
Other languages
English (en)
Other versions
DE69709377T2 (de
Inventor
Gert Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere Switzerland GmbH
Original Assignee
Scandinavian Micro Biodevices ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scandinavian Micro Biodevices ApS filed Critical Scandinavian Micro Biodevices ApS
Publication of DE69709377D1 publication Critical patent/DE69709377D1/de
Application granted granted Critical
Publication of DE69709377T2 publication Critical patent/DE69709377T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/028—Non-uniform field separators using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • G01N15/1023—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects thereof, e.g. conductivity or capacity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G01N2015/1028—
DE69709377T 1996-09-04 1997-09-04 Mikrofliesssystem für die teilchenanalyse und trennung Expired - Fee Related DE69709377T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK95396 1996-09-04
DK15097 1997-02-10
PCT/DK1997/000368 WO1998010267A1 (en) 1996-09-04 1997-09-04 A micro flow system for particle separation and analysis

Publications (2)

Publication Number Publication Date
DE69709377D1 true DE69709377D1 (de) 2002-01-31
DE69709377T2 DE69709377T2 (de) 2002-08-14

Family

ID=26063406

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709377T Expired - Fee Related DE69709377T2 (de) 1996-09-04 1997-09-04 Mikrofliesssystem für die teilchenanalyse und trennung

Country Status (10)

Country Link
US (3) US6432630B1 (de)
EP (1) EP0925494B1 (de)
JP (1) JP2002503334A (de)
AT (1) ATE211258T1 (de)
AU (1) AU4113297A (de)
CA (1) CA2264389A1 (de)
DE (1) DE69709377T2 (de)
DK (1) DK0925494T3 (de)
NO (1) NO317958B1 (de)
WO (1) WO1998010267A1 (de)

Families Citing this family (482)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
CA2230653A1 (en) 1998-02-27 1999-08-27 The Governors Of The University Of Alberta Microchip based enzymatic analysis
AU2848099A (en) * 1998-03-25 1999-10-18 Gert Blankenstein Micro system and method for field manipulation of particules
DE19815882A1 (de) 1998-04-08 1999-10-14 Fuhr Guenther Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen
EP1046032A4 (de) * 1998-05-18 2002-05-29 Univ Washington Patrone zur flüssigkeitsanalyse
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
CA2333201A1 (en) * 1998-05-22 1999-12-02 California Institute Of Technology Microfabricated cell sorter
DE19847952C2 (de) * 1998-09-01 2000-10-05 Inst Physikalische Hochtech Ev Fluidstromschalter
US6858439B1 (en) * 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
EP1169122A2 (de) * 1999-03-24 2002-01-09 Torsana Biosensor A/S Räumlich orientierte wechselwirkung auf einen festen träger
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
WO2000070080A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6613211B1 (en) 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
WO2001051918A1 (en) * 2000-01-12 2001-07-19 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US6323040B1 (en) * 2000-02-15 2001-11-27 Ryan S. Raz System for biological specimen preparation
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
JP4504501B2 (ja) * 2000-03-15 2010-07-14 株式会社東海理化電機製作所 粒子移動／固定装置
US20030186426A1 (en) * 2000-03-15 2003-10-02 The Regents Of The University Of California Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species
JP2001281233A (ja) * 2000-03-28 2001-10-10 Inst Of Physical & Chemical Res 水性分配用マイクロチップおよびそれを用いた水性分配方法
US7682837B2 (en) * 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
DE10025699A1 (de) 2000-05-23 2001-12-06 Merck Patent Gmbh Emulgier- und Trennvorrichtung für flüssige Phasen
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US7033473B2 (en) * 2000-06-14 2006-04-25 Board Of Regents, University Of Texas Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
US20050032051A1 (en) * 2000-06-19 2005-02-10 Hayes Mark A Rapid flow-based immunoassay microchip
GB0016247D0 (en) * 2000-06-30 2000-08-23 Torsana Biosensor Diagnostics Flow cell assemblies and methods of spatially directed interaction between liquids and solid surfaces
AU2000274922A1 (en) * 2000-08-08 2002-02-18 Aviva Biosciences Corporation Methods for manipulating moieties in microfluidic systems
EP1365241A2 (de) * 2000-08-21 2003-11-26 Darashkevitch, Oleg Verfahren und vorrichtung für den gleichzeitigen nachweis mehrerer komponenten in einer mischung
US20020031836A1 (en) * 2000-09-11 2002-03-14 Feldstein Mark J. Fluidics system
US20020076825A1 (en) * 2000-10-10 2002-06-20 Jing Cheng Integrated biochip system for sample preparation and analysis
US6623984B1 (en) * 2000-11-01 2003-09-23 The Cleveland Clinic Foundation MEMS-based integrated magnetic particle identification system
CA2468772C (en) 2000-11-29 2013-10-29 George E. Seidel System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
FR2817343B1 (fr) * 2000-11-29 2003-05-09 Commissariat Energie Atomique Procede et dispositifs de transport et de concentration d'un analyte present dans un echantillon
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6736978B1 (en) * 2000-12-13 2004-05-18 Iowa State University Research Foundation, Inc. Method and apparatus for magnetoresistive monitoring of analytes in flow streams
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
CN100494360C (zh) * 2001-03-22 2009-06-03 博奥生物有限公司 细胞分离方法及其应用
JP3538777B2 (ja) * 2001-03-26 2004-06-14 独立行政法人産業技術総合研究所 微小化学反応装置
EP1384022A4 (de) 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
FR2826882B1 (fr) * 2001-07-09 2003-09-12 Bio Merieux Procede de traitement de particules magnetiques et configurations d'aimants permettant la mise en oeuvre de ce procede
US20030027225A1 (en) * 2001-07-13 2003-02-06 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US20030095897A1 (en) * 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
US20050148085A1 (en) * 2001-09-16 2005-07-07 Chemometec A/S Method and a system for detecting and optinally isolating a rare event particle
GB0126281D0 (en) * 2001-11-01 2002-01-02 Astrazeneca Ab A chemical reactor
US20040214314A1 (en) * 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
AU2002352746A1 (en) * 2001-11-15 2003-06-10 Arryx, Inc. Sample chip
US20030186465A1 (en) * 2001-11-27 2003-10-02 Kraus Robert H. Apparatus used in identification, sorting and collection methods using magnetic microspheres and magnetic microsphere kits
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7252987B2 (en) * 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
GB0129374D0 (en) * 2001-12-07 2002-01-30 Univ Brunel Test apparatus
DK1335198T3 (da) * 2002-02-01 2004-07-12 Leister Process Tech Mikrofluidik-komponent og fremgangsmåde til sortering af partikler i en væske
AU2003216175A1 (en) * 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
WO2003072765A1 (en) * 2002-02-27 2003-09-04 The Regents Of The University Of Michigan Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
JP2004000144A (ja) * 2002-03-29 2004-01-08 Aisin Seiki Co Ltd 細胞分離選別装置、細胞整列用基板
CA2480728A1 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
FI118611B (fi) * 2002-04-15 2008-01-15 Labmaster Oy Eriste-elektrodilaitteet
CA2482869C (en) * 2002-04-17 2014-11-18 Manish Deshpande Method and apparatus for sorting particles
US7157274B2 (en) * 2002-06-24 2007-01-02 Cytonome, Inc. Method and apparatus for sorting particles
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6877528B2 (en) 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20070065808A1 (en) * 2002-04-17 2007-03-22 Cytonome, Inc. Method and apparatus for sorting particles
EP1507591A1 (de) * 2002-05-24 2005-02-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum überführen von molekülen aus einem chemisch reagierenden ersten strom in einen benachbarten chemisch reagierenden zweiten strom
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20040018611A1 (en) * 2002-07-23 2004-01-29 Ward Michael Dennis Microfluidic devices for high gradient magnetic separation
US7699767B2 (en) * 2002-07-31 2010-04-20 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7745203B2 (en) 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
ES2451765T3 (es) * 2002-07-31 2014-03-28 Premium Genetics (Uk) Limited Sistema y procedimiento de clasificación de materiales usando orientación holográfica con láser
NZ538462A (en) 2002-08-01 2008-06-30 Xy Inc Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
JP3898103B2 (ja) * 2002-08-26 2007-03-28 独立行政法人科学技術振興機構 細胞分析分離装置
CA2501965C (en) * 2002-09-11 2012-04-10 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ, and methods
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
AU2003270722A1 (en) * 2002-09-16 2004-04-30 Cytonome/St, Llc Method and apparatus for sorting particles
EP1551753A2 (de) 2002-09-25 2005-07-13 California Institute Of Technology Hochintegriertes mikrofluidisches netzwerk
EP1569510B1 (de) 2002-09-27 2011-11-02 The General Hospital Corporation Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
WO2004035776A1 (ja) * 2002-10-16 2004-04-29 Universal Bio Research Co., Ltd. 生体物質導入装置、生体物質導入方法および生体物質導入用磁性担体
KR20040044336A (ko) * 2002-11-12 2004-05-28 마쯔시다덴기산교 가부시키가이샤 특이결합반응 측정방법과 이에 이용하는 시약키트 및특이결합반응 측정장치
AU2003291249A1 (en) 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
WO2004068553A2 (en) * 2003-01-29 2004-08-12 The Regents Of The University Of Michigan Method for forming nanoscale features
US20050064137A1 (en) * 2003-01-29 2005-03-24 Hunt Alan J. Method for forming nanoscale features and structures produced thereby
US7190450B2 (en) * 2003-02-20 2007-03-13 Yale University Systems and methods for sorting aerosols
US20040171091A1 (en) * 2003-02-27 2004-09-02 Cell Work, Inc. Standardized evaluation of therapeutic efficacy based on cellular biomarkers
EP1602623B1 (de) * 2003-03-07 2011-08-17 Tosoh Corporation Verfahren zum Abformen einer mikrofluidischen Struktur und Form
ATE510605T1 (de) * 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
DE10311716A1 (de) 2003-03-17 2004-10-14 Evotec Oai Ag Verfahren und Vorrichtung zur Trennung von Partikeln in einer Flüssigkeitsströmung
EP2308416B1 (de) 2003-03-28 2015-01-07 Inguran, LLC Vorrichtung und Verfahren zur Bereitstellung von geschlechtssortierten Tierspermien
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
JP2006522940A (ja) * 2003-04-10 2006-10-05 ユー．エス． ジェノミクス， インコーポレイテッド マイクロチャネルにおけるポリマーの操作
JP2006523142A (ja) 2003-04-10 2006-10-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体種の形成および制御
US9815058B2 (en) 2003-05-08 2017-11-14 The University Court Of The University Of St Andrews Fractionation of particles
DE10320869A1 (de) * 2003-05-09 2004-12-16 Evotec Technologies Gmbh Verfahren und Vorrichtungen zur Flüssigkeitsbehandlung suspendierter Partikel
JP3711988B2 (ja) * 2003-05-12 2005-11-02 株式会社日立製作所 微粒子アレー分析システム、微粒子アレーキットおよび化学分析方法
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
JP4420900B2 (ja) 2003-05-19 2010-02-24 独立行政法人科学技術振興機構 細胞分離装置
GB0313197D0 (en) * 2003-06-09 2003-07-16 Imp College Innovations Ltd Free flow electrophoresis microchip, system and method
WO2004113491A1 (ja) * 2003-06-20 2004-12-29 Nitto Denko Corporation 細胞マイクロチップ
DK1664110T3 (da) * 2003-08-26 2009-01-12 Univ Danmarks Tekniske Kontinuert makromolekylær samling og magnetisk adskillelse
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
JP4533382B2 (ja) 2003-08-28 2010-09-01 セルラ・インコーポレイテッド マイクロ流体分析およびソーティング用の一体化された構造物
EP1663460B1 (de) * 2003-09-04 2015-07-08 Premium Genetics (UK) Limited Auf mehrfachlaminarströmen basierende teilchen- und zellentrennung mit lasersteuerung
FR2860006B1 (fr) * 2003-09-24 2006-12-22 Commissariat Energie Atomique Dispositif pour separer et/ou analyser plusieurs cibles moleculaires en solution dans un melange complexe
JP3787578B2 (ja) * 2003-10-29 2006-06-21 アイダエンジニアリング株式会社 マイクロチップの微細流路における液体送液方法
FR2863626B1 (fr) * 2003-12-15 2006-08-04 Commissariat Energie Atomique Procede et dispositif de division d'un echantillon biologique par effet magnetique
WO2005069015A1 (ja) 2004-01-15 2005-07-28 Japan Science And Technology Agency 化学分析装置及び化学分析方法
US20050178700A1 (en) * 2004-01-21 2005-08-18 David Tyvoll Sorting particles in parallel
US20060121624A1 (en) * 2004-03-03 2006-06-08 Huang Lotien R Methods and systems for fluid delivery
EP1765503A2 (de) * 2004-03-03 2007-03-28 The General Hospital Corporation System zur verabreichung einer verdünnten lösung
US8058056B2 (en) * 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US7258716B2 (en) * 2004-03-22 2007-08-21 Joseph Gerard Birmingham Microimpactor system having optimized impactor spacing
US20050205483A1 (en) * 2004-03-22 2005-09-22 Birmingham Joseph G Microimpactor system for collection of particles from a fluid stream
JP4643921B2 (ja) * 2004-03-26 2011-03-02 独立行政法人科学技術振興機構 流路における流体の通過を検出する方法および流体の流れを制御する方法
US7892725B2 (en) 2004-03-29 2011-02-22 Inguran, Llc Process for storing a sperm dispersion
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP2006010535A (ja) * 2004-06-25 2006-01-12 Canon Inc 標的物質捕捉方法および装置
JP2006010529A (ja) * 2004-06-25 2006-01-12 Canon Inc 磁性粒子分離装置および分離方法
JP2006007146A (ja) * 2004-06-28 2006-01-12 Canon Inc 粒子分離装置
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
ITBO20040420A1 (it) * 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
AR049732A1 (es) 2004-07-22 2006-08-30 Monsanto Co Proceso para enriquecer una poblacion de celulas de esperma
US7156365B2 (en) * 2004-07-27 2007-01-02 Kelsey-Hayes Company Method of controlling microvalve actuator
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US7595170B2 (en) * 2004-08-05 2009-09-29 Modrovich Ivan E Apparatus and method for measuring concentrations of molecules through a barrier
DE102004040785B4 (de) * 2004-08-23 2006-09-21 Kist-Europe Forschungsgesellschaft Mbh Mikrofluidisches System zur Isolierung biologischer Partikel unter Verwendung der immunomagnetischen Separation
JP2006087336A (ja) * 2004-09-22 2006-04-06 Shimadzu Corp 細胞分析装置
ITBO20040601A1 (it) * 2004-09-30 2004-12-30 Ima Spa Metodo per il controllo di capsule
DE102004047953A1 (de) * 2004-10-01 2006-04-20 Rudolf Rigler Selektion von Partikeln im laminaren Fluss
DE102004048443B3 (de) * 2004-10-02 2005-12-01 C.D. Wälzholz-Brockhaus GmbH Verfahren zur walztechnischen Verformung von draht- und stabförmigem Vormaterial, Vorrichtung zur Durchführung des Verfahrens sowie nach dem Verfahren hergestelltes Flachprofil
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7534097B2 (en) * 2004-10-15 2009-05-19 Nanyang Technological University Method and apparatus for controlling multi-fluid flow in a micro channel
DE102004055662A1 (de) * 2004-11-18 2006-06-01 Evotec Technologies Gmbh Mikrofluidisches System mit einer Kanalaufweitung
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
JP4601423B2 (ja) * 2004-12-28 2010-12-22 独立行政法人科学技術振興機構 細胞計測および分離チップ
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
KR20070116585A (ko) 2005-01-18 2007-12-10 바이오셉트 인코포레이티드 패턴화된 포스트를 갖는 마이크로채널을 이용하는 세포분리법
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
JP4047336B2 (ja) * 2005-02-08 2008-02-13 独立行政法人科学技術振興機構 ゲル電極付セルソーターチップ
US20070054119A1 (en) * 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
JP2008535644A (ja) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
FR2882939B1 (fr) * 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
EP2594631A1 (de) * 2005-04-05 2013-05-22 Cellpoint Diagnostics Vorrichtungen und Verfahren zur Nachweisen von zirkulierenden Tumorzellen und anderen Partikeln
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20060223178A1 (en) * 2005-04-05 2006-10-05 Tom Barber Devices and methods for magnetic enrichment of cells and other particles
WO2006119806A1 (en) * 2005-05-13 2006-11-16 Agilent Technologies, Inc. Fluid cell with sheath flow
WO2006128098A2 (en) * 2005-05-27 2006-11-30 Applera Corporation Cytometric system including nucleic acid sequence amplification, and method
US20090317798A1 (en) * 2005-06-02 2009-12-24 Heid Christian A Analysis using microfluidic partitioning devices
EP2463386B1 (de) 2005-06-15 2017-04-12 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige Mischungen von sich überlappenden Fragmenten
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
CA2552456A1 (en) * 2005-07-18 2007-01-18 Barry Ruddick Apparatus, system and method for evaluating fluid systems
ITBO20050481A1 (it) * 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US20070025879A1 (en) * 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20090201504A1 (en) * 2005-08-09 2009-08-13 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
US8232092B2 (en) * 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
US7858307B2 (en) * 2005-08-09 2010-12-28 Maxwell Sensors, Inc. Light transmitted assay beads
DE102005039175A1 (de) * 2005-08-18 2007-02-22 Qiagen Gmbh Vorrichtung und Verfahren zum Abtrennen von magnetischen Partikeln aus einer Flüssigkeit
EP1928570B1 (de) * 2005-08-22 2015-04-15 Life Technologies Corporation Vorrichtung, system und verfahren unter verwendung von diskreten volumina nicht mischbarer fluide
JP4745755B2 (ja) * 2005-08-23 2011-08-10 セイコーインスツル株式会社 分画マイクロチップ及び分画装置
US20070059782A1 (en) * 2005-09-13 2007-03-15 Graham Henry A Magnetic particle tagged blood bank reagents and techniques
US9488665B2 (en) * 2005-09-13 2016-11-08 Chrome Red Technologies, Llc Magnetic particle tagged reagents and techniques
AU2006292394A1 (en) * 2005-09-15 2007-03-29 Artemis Health, Inc. Systems and methods for enrichment of analytes
WO2007044642A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
JP4692200B2 (ja) * 2005-10-06 2011-06-01 横河電機株式会社 化学処理用カートリッジおよびその使用方法
ITBO20050646A1 (it) * 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
US20070178067A1 (en) * 2005-11-09 2007-08-02 John Maier System and method for cytological analysis by raman spectroscopic imaging
US7540206B2 (en) * 2005-11-14 2009-06-02 Parker-Hannifin Corporation Self-cleaning sample extraction system
US20080193919A1 (en) * 2005-11-30 2008-08-14 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and methods for receiving pathogen related information and responding
US8068991B2 (en) * 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US20080241000A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for pathogen detection
US20080179255A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic devices
US20080178692A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US20080241909A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for pathogen detection
US20080241910A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for pathogen detection
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9878326B2 (en) 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
WO2007081386A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
CN101004423B (zh) * 2006-01-19 2011-12-28 博奥生物有限公司 流体样品分析用卡盒系统
CN101375166B (zh) * 2006-01-25 2013-07-10 皇家飞利浦电子股份有限公司 用于分析流体的装置
US20100252507A1 (en) * 2006-01-26 2010-10-07 Frederic Lacharme Magnetic Bead Retention Apparatus and Method
AU2007210152A1 (en) * 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
US8293524B2 (en) * 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US20090181864A1 (en) * 2006-03-31 2009-07-16 Nam Trung Nguyen Active control for droplet-based microfluidics
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2047910B1 (de) * 2006-05-11 2012-01-11 Raindance Technologies, Inc. Mikrofluidische Vorrichtung und Verfahren
DE602006021151D1 (de) * 2006-05-11 2011-05-19 Corning Inc Modulares Halte- und Verbindungssystem für microfluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
JP5032792B2 (ja) * 2006-05-22 2012-09-26 浜松ホトニクス株式会社 細胞選別装置
MX2008014732A (es) 2006-05-22 2009-04-07 Univ Columbia Sistemas y metodos de intercambio sin membrana microfluidica usando filtracion de corrientes de salida de fluidos de extraccion.
WO2008016414A2 (en) * 2006-06-01 2008-02-07 The Trustees Of Princeton University Apparatus and method for continuous particle separation
US8296088B2 (en) * 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US20080070792A1 (en) * 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080090239A1 (en) * 2006-06-14 2008-04-17 Daniel Shoemaker Rare cell analysis using sample splitting and dna tags
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
GB0612825D0 (en) * 2006-06-28 2006-08-09 Iti Scotland Ltd Analyte detection
GB0614297D0 (en) * 2006-07-19 2006-08-30 Shaw Water Engineering Ltd Apparatus, system and method for detecting particles
KR100846491B1 (ko) * 2006-07-25 2008-07-17 삼성전자주식회사 미세유동 장치 내에서 표적 생체분자의 분리 및 정제를 위한 자성 비드 추출 장치
EP3536396B1 (de) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
GB0616508D0 (en) * 2006-08-18 2006-09-27 Iti Scotland Ltd Analyte manipulation and detection
US8524173B2 (en) 2006-09-01 2013-09-03 Tosoh Corporation Microchannel structure and fine-particle production method using the same
GB0618605D0 (en) 2006-09-21 2006-11-01 Univ St Andrews Optical sorting
GB0618606D0 (en) 2006-09-21 2006-11-01 Univ St Andrews Optical sorting
US20120122731A1 (en) * 2006-10-18 2012-05-17 Hyongsok Soh Screening molecular libraries using microfluidic devices
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
JP4984849B2 (ja) * 2006-11-27 2012-07-25 パナソニック株式会社 成分分離デバイスと、この成分分離デバイスを用いた化学分析デバイス
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
WO2008085991A2 (en) 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
EP2125171A4 (de) 2007-01-10 2012-05-16 Univ Michigan Ultrafiltriermembran, vorrichtung, bioartifizielles organ und entsprechende verfahren
GB0701641D0 (en) * 2007-01-29 2007-03-07 Iti Scotland Ltd Analyte manipulation and detection
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US20090050569A1 (en) * 2007-01-29 2009-02-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
US20080181821A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for allergen detection
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008096302A1 (en) 2007-02-07 2008-08-14 Koninklijke Philips Electronics N. V. Means for the separation of magnetic particles
US20090081750A1 (en) * 2007-02-14 2009-03-26 Bio-Rad Laboratories, Inc. Transfection in magnetically driven continuous flow
US20090227005A1 (en) * 2007-03-27 2009-09-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
WO2008121342A2 (en) * 2007-03-28 2008-10-09 President And Fellows Of Harvard College Emulsions and techniques for formation
US20080237044A1 (en) * 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules
ATE538377T1 (de) 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
WO2008130977A2 (en) 2007-04-16 2008-10-30 The General Hospital Corporation D/B/A Massachusetts General Hospital Systems and methods for particle focusing in microchannels
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2008130618A1 (en) * 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
WO2009014792A2 (en) * 2007-05-11 2009-01-29 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Electrical detection using confined fluids
WO2008147530A1 (en) * 2007-05-24 2008-12-04 The Regents Of The University Of California Integrated fluidics devices with magnetic sorting
US8921121B2 (en) * 2007-06-29 2014-12-30 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for chemiluminescence-based microfluidic cell counting
WO2009006456A1 (en) 2007-06-29 2009-01-08 The Trustees Of Columbia University Microfluidic device for counting biological particles
WO2009021215A1 (en) * 2007-08-09 2009-02-12 Celula, Inc. Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material
US20110290330A1 (en) * 2007-08-09 2011-12-01 Agilent Technologies, Inc. Fluid flow control in a microfluidic device
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
GB2464433B (en) * 2007-08-23 2012-06-20 Cynvenio Biosystems Llc Trapping magnetic sorting system for target species
CA2734029C (en) 2007-08-30 2016-03-29 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
WO2009034563A2 (en) * 2007-09-14 2009-03-19 Nanocomms Patents Limited An analysis system
EP2215441A2 (de) * 2007-10-25 2010-08-11 The Research Foundation of the State University of New York Einzelphotonen-spektrometer
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
EP2215453A1 (de) * 2007-11-22 2010-08-11 Koninklijke Philips Electronics N.V. Kombinierte optische und elektrische sensorkartuschen
KR101338349B1 (ko) * 2007-11-30 2013-12-06 연세대학교 산학협력단 미세입자 분리 장치 및 이의 제작 방법
US9656271B2 (en) * 2007-12-04 2017-05-23 Headway Technologies, Inc. Guided transport of magnetically labeled biological molecules and cells
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
KR100907213B1 (ko) 2007-12-07 2009-07-10 한국과학기술원 등자기영동 기술을 이용한 미세입자 분리 장치 및등자기영동 기술을 이용한 미세입자 분리 방법
EP2229441B1 (de) * 2007-12-12 2014-10-01 The Board of Trustees of The Leland Stanford Junior University Verfahren und vorrichtung zur magnetischen trennung von zellen
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
KR101384142B1 (ko) * 2007-12-28 2014-04-14 삼성디스플레이 주식회사 표시기판, 이의 제조방법 및 이를 갖는 표시장치
US8001855B2 (en) * 2008-01-14 2011-08-23 Medi Medical Engineering Corp. Fluid transferring apparatus
JP2009168650A (ja) * 2008-01-17 2009-07-30 Sekisui Chem Co Ltd カートリッジ式電気化学分析装置及び方法
US8496606B2 (en) 2008-02-04 2013-07-30 The Trustees Of Columbia University In The City Of New York Fluid separation devices, systems and methods
KR100965399B1 (ko) 2008-02-14 2010-06-24 연세대학교 산학협력단 전자석의 주울열을 이용하여 채널내 세포의 최적온도조절이 가능한 자성세포분리장치
NL2001322C2 (nl) * 2008-02-27 2009-08-31 Univ Delft Tech Werkwijze en inrichting voor het scheiden van vaste deeltjes met een onderling dichtheidsverschil.
WO2009117611A2 (en) * 2008-03-19 2009-09-24 Cynvenio Biosystems, Llc Trapping magnetic cell sorting system
EP2271919A1 (de) * 2008-04-16 2011-01-12 Cynvenio Biosystems, Inc. Magnetisches trennsystem mit vor- und nachbearbeitungsmodulen
WO2009132151A2 (en) * 2008-04-23 2009-10-29 The Regents Of The University Of California Microfluidic devices and methods of using same
JP4661942B2 (ja) * 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
JP4572973B2 (ja) * 2008-06-16 2010-11-04 ソニー株式会社 マイクロチップ及びマイクロチップにおける送流方法
GB0812781D0 (en) * 2008-07-11 2008-08-20 Deltadot Ltd Material separation device
EP2315629B1 (de) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Tröpfchenbibliotheken
US9180453B2 (en) * 2008-08-15 2015-11-10 University Of Washington Method and apparatus for the discretization and manipulation of sample volumes
EP3378951B1 (de) 2008-09-20 2020-05-13 The Board of Trustees of the Leland Stanford Junior University Nicht invasive diagnose von aneuploidie durch sequenzierung
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
WO2010041230A2 (en) * 2008-10-10 2010-04-15 Cnrs-Dae Microfluidic integrated device for sample processing
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
JP2010151777A (ja) * 2008-11-19 2010-07-08 Sony Corp 微小粒子解析装置、微小粒子解析用マイクロチップ及び微小粒子解析方法
WO2010123594A2 (en) 2009-01-15 2010-10-28 Children's Medical Center Corporation Device for filtration of fluids there through and accompanying method
US8162149B1 (en) 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
DE102009005925B4 (de) 2009-01-23 2013-04-04 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zur Handhabung von Biomolekülen
US20100298453A1 (en) * 2009-01-26 2010-11-25 Invista North America S.A R.L. Board stock foam having biobased content
JP5382852B2 (ja) 2009-02-06 2014-01-08 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
US8828715B2 (en) * 2009-03-06 2014-09-09 Cfd Research Corporation Particle adhesion assay for microfluidic bifurcations
SG174459A1 (en) 2009-03-17 2011-10-28 Silicon Biosystems Spa Microfluidic device for isolation of cells
ITBO20090154A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
JP5333752B2 (ja) * 2009-03-27 2013-11-06 セイコーエプソン株式会社 細胞分離装置および細胞分離方法
JP4893794B2 (ja) * 2009-09-14 2012-03-07 セイコーエプソン株式会社 細胞分離装置
US8343440B2 (en) 2009-03-27 2013-01-01 Seiko Epson Corporation Cell separating apparatus and cell separating method
JP5248394B2 (ja) * 2009-03-30 2013-07-31 シャープ株式会社 被検体物質の固定化方法およびマイクロ分析装置
NL2002736C2 (en) 2009-04-09 2010-10-12 Univ Delft Tech Method for separating magnetic pieces of material.
WO2010117458A1 (en) 2009-04-10 2010-10-14 President And Fellows Of Harvard College Manipulation of particles in channels
US10031061B2 (en) 2009-05-13 2018-07-24 Intellicyt Corporation Flow measurement and control for improved quantification of particles in flow cytometry
US8790916B2 (en) * 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
JP2011013208A (ja) * 2009-06-05 2011-01-20 Advance Co Ltd 生物学的操作システム及び工業的操作システム
CN102713640B (zh) * 2009-06-10 2015-09-16 辛温尼奥生物系统公司 鞘流装置和方法
SG177369A1 (en) 2009-06-26 2012-02-28 Harvard College Fluid injection
DE102009030688A1 (de) 2009-06-26 2010-12-30 Carl Zeiss Ag Mikroskopische Detektion von Objekten in einem Fluidstrom
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
US8834807B2 (en) 2009-08-12 2014-09-16 Caliper Life Sciences, Inc. Device and method for improving sample injection and stacking
US8202486B2 (en) * 2009-08-12 2012-06-19 Caliper Life Sciences, Inc. Pinching channels for fractionation of fragmented samples
TW201113523A (en) 2009-08-31 2011-04-16 Mbio Diagnostics Inc Integrated sample preparation and analyte detection
WO2011028764A2 (en) 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
US9625454B2 (en) * 2009-09-04 2017-04-18 The Research Foundation For The State University Of New York Rapid and continuous analyte processing in droplet microfluidic devices
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
SG170702A1 (en) * 2009-10-20 2011-05-30 Agency Science Tech & Res Microfluidic system for trapping and detection of a biological entity in a sample
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
EP3671180B1 (de) 2010-01-15 2023-03-08 On-chip Biotechnologies Co., Ltd. Verfahren zur verwendung einer vorrichtung, die zum trennen biologischer partikel konfiguriert ist
CA2787135C (en) 2010-01-21 2018-11-20 Biocep Ltd. Magnetic separation of rare cells
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
ES2544635T3 (es) * 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
AU2011236503B2 (en) 2010-04-07 2014-10-30 Biosensia Patents Limited Flow control device for assays
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
JP2011237201A (ja) * 2010-05-06 2011-11-24 Sony Corp 微小粒子分取装置、マイクロチップ及びマイクロチップモジュール
JP5268989B2 (ja) * 2010-05-11 2013-08-21 株式会社日立ハイテクノロジーズ 核酸分析反応セルおよび核酸分析装置
GB2482658A (en) 2010-07-08 2012-02-15 Univ Dublin Non-linear magnetophoresis system
ITBO20100503A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
ITBO20100505A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
US9803236B2 (en) 2010-08-06 2017-10-31 Tsinghua University Microarray-based assay integrated with particles for analyzing molecular interactions
US8468680B2 (en) 2010-08-24 2013-06-25 Roche Diagnostics Operations, Inc. Biosensor test member and method for making the same
KR20120026959A (ko) * 2010-09-10 2012-03-20 인제대학교 산학협력단 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
DE102010042737A1 (de) * 2010-10-21 2012-04-26 Siemens Aktiengesellschaft Magnetische Durchflusszytometrie
US9090865B2 (en) 2010-10-29 2015-07-28 The Regents Of The University Of California Systems and methods for particle classification and sorting
CN102019277B (zh) * 2010-10-29 2013-05-22 北京惟馨雨生物科技有限公司 一种用于细胞和颗粒分离的分选仪及分选方法
JP2012095550A (ja) * 2010-10-29 2012-05-24 Sony Corp 細胞分取装置、細胞分取チップ及び細胞分取方法
JP5732816B2 (ja) * 2010-10-29 2015-06-10 ソニー株式会社 細胞分取装置及び細胞分取チップ
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
WO2012067985A2 (en) * 2010-11-18 2012-05-24 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
US9815060B2 (en) 2010-11-18 2017-11-14 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
CN105107228B (zh) * 2010-12-06 2017-03-29 颇尔公司 生物制品的连续加工方法
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
US8371683B2 (en) 2010-12-23 2013-02-12 Palo Alto Research Center Incorporated Particle removal device for ink jet printer
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20120214224A1 (en) * 2011-02-01 2012-08-23 Chan Eugene Y Flow based clinical analysis
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US20130000738A1 (en) * 2011-02-28 2013-01-03 Pathogenetix, Inc. Method and system for transferring and/or concentrating a sample
DE102011015321A1 (de) 2011-03-28 2012-10-04 Ralph Heindrichs Verfahren zur kontinuierlichen selektiven Separation von Partikeln mittels Magnetismus
CA2831857A1 (en) * 2011-04-01 2012-10-04 Children's Medical Center Corporation Dialysis like therapeutic (dlt) device
ES2837407T3 (es) 2011-04-05 2021-06-30 Purdue Research Foundation Sistema microfluídico usando microaberturas para detección con alto rendimiento de entidades
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
EP2701850B1 (de) 2011-04-27 2018-08-15 Becton Dickinson and Company Vorrichtungen und verfahren zur abtrennung magnetisch markierter teile in einer probe
US20140038259A1 (en) * 2011-04-29 2014-02-06 Becton, Dickinson And Company Fluidic in-line particle immobilization and collection systems and methods for using the same
DE102011076051A1 (de) * 2011-05-18 2012-11-22 Siemens Aktiengesellschaft Magnetophoretische Analytselektion und -anreicherung
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
JP2014522718A (ja) 2011-07-06 2014-09-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 多相エマルションおよび多相エマルション形成法
US10240186B2 (en) 2011-07-14 2019-03-26 Fluxion Biosciences, Inc. Devices, systems, and methods for magnetic separation
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
GB201113007D0 (en) * 2011-07-28 2011-09-14 Q Chip Ltd Bead collection device and method
US20130029355A1 (en) * 2011-07-28 2013-01-31 Electronics And Telecommunications Research Institute Multiple analysis device and method for analyzing cancer cells in blood
US20130075318A1 (en) * 2011-09-23 2013-03-28 Xiaojing Zhang Apparatus for Isolating Rare Cells from Blood Samples
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
EP2644258A1 (de) * 2012-03-29 2013-10-02 Roche Diagniostics GmbH Mikroflussfiltrationssystem und Flussfiltrationsverfahren für eine Flüssigkeitsprobe
EP2644259A1 (de) 2012-03-29 2013-10-02 Roche Diagniostics GmbH Mikroflussfiltrationssystem und Flussfiltrationsverfahren
JP2015514425A (ja) 2012-04-17 2015-05-21 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 垂直３ストリームマイクロ流体デバイスのための入口および出口の幾何学的形態
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9517474B2 (en) 2012-05-18 2016-12-13 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
CN104471077B (zh) 2012-05-21 2017-05-24 富鲁达公司 颗粒群的单颗粒分析
DE102012211626A1 (de) * 2012-07-04 2014-01-09 Siemens Aktiengesellschaft Anordnung zur Quantifizierung von Zellen einer Zellsuspension
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
JP5910412B2 (ja) * 2012-08-16 2016-04-27 ソニー株式会社 微小粒子分取方法及び微小粒子分取用マイクロチップ
CN104736718A (zh) 2012-10-26 2015-06-24 贝克顿·迪金森公司 用于操纵流体样品中的组分的装置和方法
US20140151229A1 (en) * 2012-12-05 2014-06-05 Caliper Life Sciences, Inc. Manipulation of objects in microfluidic devices using external electrodes
US20140168328A1 (en) * 2012-12-18 2014-06-19 Palo Alto Research Center Incorporated Non-spherical particle separator for ink jet printer
KR101356933B1 (ko) * 2012-12-28 2014-01-29 고려대학교 산학협력단 표면탄성파를 이용한 미세유동 크로마토 그래피 기반 미세입자 분리 장치 및 방법
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
FR3001038B1 (fr) * 2013-01-17 2018-02-09 Centre National De La Recherche Scientifique (Cnrs) Procede de capture, procede de detection et kit de capture d'une molecule dans un echantillon
US9322013B2 (en) * 2013-02-25 2016-04-26 Los Alamos National Security, Llc Magnetic separation of algae
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US20160299132A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for bead-based assays in ferrofluids
WO2014144782A2 (en) 2013-03-15 2014-09-18 Ancera, Inc. Systems and methods for active particle separation
CN103196725B (zh) * 2013-03-26 2015-07-08 上海交通大学 制备与富集单个微纳米珠携带单根多聚物分子的方法
CN103194371B (zh) * 2013-03-26 2014-12-24 上海交通大学 生物复合物的分离与收集装置
CN103217311B (zh) * 2013-03-26 2015-04-01 上海交通大学 生物复合物的分离与收集方法
CN103194370B (zh) * 2013-03-26 2014-12-24 上海交通大学 制备与富集单个微纳米珠携带单根多聚物分子的装置
CN103305603B (zh) * 2013-03-26 2015-05-20 上海交通大学 单分子生物反应器制备单微纳米珠携带单根多聚物的方法
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
JP5780274B2 (ja) * 2013-07-31 2015-09-16 セイコーエプソン株式会社 細胞回収方法
CN108051590B (zh) 2013-09-13 2020-12-11 Symbolics有限责任公司 运用二维试验和对照信号读出模式的侧向层析检测
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015052034A1 (en) * 2013-10-07 2015-04-16 Devrim Pesen Okvur Microfluidic device for investigation of distance dependent interactions in cell biology
US10202577B2 (en) * 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
GB201320146D0 (en) * 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
EP3108219B1 (de) * 2014-02-20 2020-04-01 Malvern Panalytical Limited Charakterisierung heterogener flüssigkeitsproben
DE102014203285A1 (de) * 2014-02-24 2015-08-27 Miltenyi Biotec Gmbh Hydrodynamische Fokussierungseinheit
US20170074870A1 (en) 2014-03-14 2017-03-16 Northeastern University Microfluidic System and Method for Real-Time Measurement of Antibody-Antigen Binding and Analyte Detection
US8820538B1 (en) * 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
DE102014205949A1 (de) * 2014-03-31 2015-10-01 Siemens Aktiengesellschaft Durchflusskammer für einen Durchflusszytometer sowie Durchflusszytometer
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
US10031104B2 (en) 2014-06-13 2018-07-24 Yes Way Intellectual Holdings, Llc Mobile micro-lab for chemical analysis of fluids
KR101984559B1 (ko) * 2014-08-20 2019-05-31 스템 셀 에스.알.엘. 대상물의 분류를 위한 장치 및 분류 방법
DE102014112270B3 (de) 2014-08-27 2015-04-23 Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. Verfahren zur Messung der Thrombozytenfunktion
EP3187854B1 (de) * 2014-08-28 2020-08-19 Sysmex Corporation Partikelbildaufnahmevorrichtung und partikelbildaufnahmeverfahren
DE102014116567A1 (de) * 2014-11-12 2016-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zum Sortieren von Mikropartikeln in einem Fluidstrom
WO2016132222A2 (en) 2015-02-19 2016-08-25 Premium Genetics (Uk) Ltd. Scanning infrared measurement system
US10167502B2 (en) 2015-04-03 2019-01-01 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
US11725179B2 (en) 2015-05-12 2023-08-15 On-Chip Biotechnologies Co., Ltd. Single-particle analysis method, and system for performing said analysis
US11285490B2 (en) 2015-06-26 2022-03-29 Ancera, Llc Background defocusing and clearing in ferrofluid-based capture assays
ES2599056B2 (es) * 2015-07-31 2017-07-07 Pablo ALBERTOS SÁNCHEZ Dispositivo para ensayar una muestra de células
US10676719B2 (en) 2015-07-31 2020-06-09 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
DE102015218177B4 (de) 2015-09-22 2022-09-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Isolation und Anreicherung magnetisch markierter Zellen im Durchfluss
KR20180061336A (ko) * 2015-10-02 2018-06-07 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 자기 부상을 이용한 생물학적 및 비-생물학적 모이어티의 분류
ES2757076T3 (es) * 2015-11-30 2020-04-28 Rqmicro Ag Dispositivo microfluídico, conjuntos y procedimiento para extraer partículas de una muestra
CN105536664B (zh) * 2015-12-12 2017-06-20 西安交通大学 一种用于可控筛选流体中粒子的微反应器的制备方法
KR101855490B1 (ko) * 2016-01-22 2018-05-08 한국과학기술원 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법
EP3411710A1 (de) * 2016-02-05 2018-12-12 The Broad Institute Inc. Mehrstufige, multiplexierte zielisolierung und -verarbeitung aus heterogenen populationen
US20170259262A1 (en) * 2016-03-09 2017-09-14 Intelligent Bio-Systems, Inc. Laminar fluidic separation in flowcells for minimal reagent usage
WO2017181258A1 (en) * 2016-04-21 2017-10-26 Duane Hewitt Continuous flow system
US10189029B2 (en) * 2016-06-30 2019-01-29 United Arab Emirates University Magnetic particle separator
US9968943B2 (en) * 2016-06-30 2018-05-15 United Arab Emirates University Magnetic particle separator
EP3514518A4 (de) 2016-09-16 2020-09-02 On-chip Biotechnologies Co., Ltd. Feinpartikelabgabevorrichtung, feinpartikelanalysevorrichtung, reaktionserkennungsvorrichtung und verfahren unter verwendung dieser vorrichtungen
WO2018184002A1 (en) * 2017-04-01 2018-10-04 Biomagnetic Solutions Llc Devices and methods for one-step static or continuous magnetic separation
GB201706947D0 (en) 2017-05-02 2017-06-14 Cytosight Ltd Fluid sample enrichment system
US10350611B2 (en) * 2017-06-27 2019-07-16 General Electric Company Apparatus and methods for particle separation by ferrofluid constriction
WO2019017875A1 (en) * 2017-07-17 2019-01-24 Hewlett-Packard Development Company, L.P. DIELECTROPHORESIS SEPARATORS WITH CELL EJECTION DEVICES
CN107340226A (zh) * 2017-08-03 2017-11-10 江苏大学 一种油液中悬浮微粒计数检测装置及其应用
WO2019028445A1 (en) * 2017-08-04 2019-02-07 University Of Georgia Research Foundation, Inc. DEVICES AND METHODS FOR SEPARATING CIRCULATING TUMOR CELLS FROM BIOLOGICAL SAMPLES
US11648559B2 (en) 2017-08-04 2023-05-16 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
US11292000B2 (en) 2017-08-04 2022-04-05 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
KR20190016011A (ko) * 2017-08-07 2019-02-15 울산과학기술원 자성 입자를 이용한 유체 분리 시스템 및 방법
KR102327920B1 (ko) * 2017-12-28 2021-11-17 인하대학교 산학협력단 결정성 나노셀룰로오스의 길이별 분리장치
KR102260437B1 (ko) * 2017-12-28 2021-06-02 인하대학교 산학협력단 결정성 나노셀룰로오스의 길이별 분리장치
DE102018104669A1 (de) * 2018-03-01 2019-09-05 Dionex Softron Gmbh Verwendung einer akustischen Welle in einem Chromatographiesystem
DE112019001098T5 (de) * 2018-03-02 2021-02-04 Sony Corporation Verfahren zum optimieren von feinteilchenansaugbedingung, feinteilchentrennungsvorrichtung, feinteilchentrennungssystem und feinteilchentrennungsprogramm
US20200200734A1 (en) * 2018-04-23 2020-06-25 Anpac Bio-Medical Science Co., Ltd. New Apparatus and Methods for Disease Detection
CN112368079A (zh) * 2018-04-30 2021-02-12 联合治疗学有限公司 用于控制流体流动的设备和方法
US11413378B2 (en) 2018-05-08 2022-08-16 Biomagnetic Solutions Llc Rigid chamber for cell separation from a flexible disposable bag
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
WO2019230489A1 (ja) * 2018-06-01 2019-12-05 ソニー株式会社 マイクロチップ及びサンプル分取キット
CN108680403B (zh) * 2018-06-21 2024-03-29 重庆交通大学 附加压流式多级亚微米粒子采集器
CN109174445B (zh) * 2018-08-23 2020-03-31 山东路友再生资源设备有限公司 一种飞秒激光涡流磁选机
EP3857215A4 (de) * 2018-09-24 2022-06-22 Hewlett-Packard Development Company, L.P. Partikeltrennung aus vollblut
US11073466B2 (en) 2018-10-03 2021-07-27 Verily Life Sciences Llc Systems and methods for maintaining constant volumetric flow rates in a fluid channel
US11137337B2 (en) 2019-01-21 2021-10-05 Essen Instruments, Inc. Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation
CN109856398B (zh) * 2019-01-31 2022-04-29 京东方科技集团股份有限公司 疫苗检测装置及其检测方法
KR102279854B1 (ko) * 2019-02-13 2021-07-21 인제대학교 산학협력단 자기영동을 이용한 음성수집 방식의 미세입자 분리장치 및 그 분리방법
ES2871925T3 (es) * 2019-03-19 2021-11-02 Ace Medical Tech Co Ltd Dispositivo para clasificar biopartículas utilizando una fuerza generada a partir de dielectroforesis inducida por luz y su método de funcionamiento
BR112021020390A2 (pt) 2019-04-18 2022-01-18 Abs Global Inc Sistema de distribuição de crioprotetor, sistema de criopreservação para distribuir um crioprotetor a um espécime biológico, método para distribuir um crioprotetor a um espécime biológico, sistema de distribuição e método para preparar um espécime biológico para criopreservação
GB2587061B (en) * 2019-06-05 2023-09-13 Jaguar Land Rover Ltd Device for manipulating a substance
CN110438000B (zh) * 2019-07-24 2021-10-12 中山大学 双频驻波声场分离循环肿瘤细胞及其微栓的装置与方法
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US11709116B2 (en) 2020-02-04 2023-07-25 Sartorius Bioanalytical Instruments, Inc. Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods
US20220088604A1 (en) * 2020-09-24 2022-03-24 Micareo Taiwan Co., Ltd. Microfluidic chip and device
US11951476B2 (en) * 2020-11-19 2024-04-09 Rutgers, The State University Of New Jersey Electronic-sensing and magnetic-modulation (ESMM) biosensor for phagocytosis quantification in pathogenic infections and methods of use thereof
CN112871750B (zh) * 2021-01-26 2022-12-02 华南师范大学 基于级联式微型热源的颗粒分选芯片及其颗粒分选方法
WO2023153331A1 (ja) * 2022-02-08 2023-08-17 京セラ株式会社 流路デバイスの準備方法
US11802870B1 (en) * 2022-12-13 2023-10-31 Panazee Kinetic immunoassay systems and methods

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1894146A (en) * 1931-04-30 1933-01-10 John S Baker Score card holder or writing tablet
US3560754A (en) 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3827555A (en) * 1973-03-05 1974-08-06 Bio Physics Systems Inc Particle sorter with segregation indicator
US4279345A (en) 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
ATE48477T1 (de) 1984-09-11 1989-12-15 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
EP0196205A2 (de) 1985-03-27 1986-10-01 The Standard Oil Company Einrichtung zur Aussonderung von teilchenartigem Material
DE3522365A1 (de) 1985-06-22 1987-01-02 Bayer Ag Trenngeraet fuer magnetische partikel aus fluessiger phase
US4894146A (en) 1986-01-27 1990-01-16 University Of Utah Thin channel split flow process and apparatus for particle fractionation
NO162946C (no) 1987-08-21 1990-03-14 Otto Soerensen Anordning for magnetisk separasjon av celler.
US5053344A (en) * 1987-08-04 1991-10-01 Cleveland Clinic Foundation Magnetic field separation and analysis system
US5123901A (en) 1988-02-25 1992-06-23 Carew E Bayne Method for separating pathogenic or toxic agents from a body fluid and return to body
US5039426A (en) 1988-05-17 1991-08-13 University Of Utah Process for continuous particle and polymer separation in split-flow thin cells using flow-dependent lift forces
DE3827252A1 (de) 1988-08-11 1990-02-15 Unkelbach Karl Heinz Dr Verfahren und vorrichtung zum kontinuierlichen trennen von biologische mikrosysteme und zellen enthaltenden mischungen
US5092973A (en) 1990-01-26 1992-03-03 The Board Of Trustees Of The Leland Stanford Junior University Rectangular capillaries for capillary electrophoresis
GB9008044D0 (en) 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
US5460797A (en) * 1991-05-08 1995-10-24 Streck Laboratories, Inc. Method for fixing tissues and cells for analysis using oxazolidine compounds
EP0637997B1 (de) * 1992-05-01 1998-07-01 Trustees Of The University Of Pennsylvania Analyse bei messung des durchflusswiderstandes
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
TW239881B (de) 1992-12-22 1995-02-01 Sienna Biotech Inc
EP0682671A4 (de) * 1993-02-01 1998-01-14 Seq Ltd Verfahren und geräte zur sequenzierung von dns.
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
JPH07232097A (ja) 1994-02-24 1995-09-05 Power Reactor & Nuclear Fuel Dev Corp 磁気クロマトグラフィー法による群分離方法
JPH10507632A (ja) 1994-09-20 1998-07-28 ミルテニー バイオテック，インコーポレイティド 母体からの胎児血液の濃縮
US5528045A (en) 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter

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AU4113297A (en) 1998-03-26
US20070207548A1 (en) 2007-09-06
NO991051D0 (no) 1999-03-03
WO1998010267A1 (en) 1998-03-12
US6432630B1 (en) 2002-08-13
US7138269B2 (en) 2006-11-21
EP0925494A1 (de) 1999-06-30
US20030044832A1 (en) 2003-03-06
CA2264389A1 (en) 1998-03-12
JP2002503334A (ja) 2002-01-29
DK0925494T3 (da) 2002-07-01
DE69709377T2 (de) 2002-08-14
NO317958B1 (no) 2005-01-17

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