DE69633782D1 - Vorrichtung undverfahren zum bestimmen der raumkoordinaten von radiomarkiertem gewebe - Google Patents
Vorrichtung undverfahren zum bestimmen der raumkoordinaten von radiomarkiertem gewebeInfo
- Publication number
- DE69633782D1 DE69633782D1 DE69633782T DE69633782T DE69633782D1 DE 69633782 D1 DE69633782 D1 DE 69633782D1 DE 69633782 T DE69633782 T DE 69633782T DE 69633782 T DE69633782 T DE 69633782T DE 69633782 D1 DE69633782 D1 DE 69633782D1
- Authority
- DE
- Germany
- Prior art keywords
- ray
- gamma
- signal
- rays
- characteristic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/482—Diagnostic techniques involving multiple energy imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4057—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/16—Measuring radiation intensity
- G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/392—Radioactive markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nuclear Medicine (AREA)
- Measurement Of Radiation (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Radio Relay Systems (AREA)
- Radar Systems Or Details Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/430,589 US5694933A (en) | 1995-04-28 | 1995-04-28 | Apparatus and methods for determining spatial coordinates of radiolabelled tissue using gamma-rays and associated characteristic X-rays |
US430589 | 1995-04-28 | ||
PCT/US1996/005479 WO1996033652A1 (en) | 1995-04-28 | 1996-04-19 | Apparatus and methods for determining spatial coordinates of using radio labelled tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69633782D1 true DE69633782D1 (de) | 2004-12-09 |
DE69633782T2 DE69633782T2 (de) | 2005-11-03 |
Family
ID=23708210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69633782T Expired - Lifetime DE69633782T2 (de) | 1995-04-28 | 1996-04-19 | Vorrichtung undverfahren zum bestimmen der raumkoordinaten von radiomarkiertem gewebe |
Country Status (7)
Country | Link |
---|---|
US (2) | US5694933A (de) |
EP (1) | EP0830079B1 (de) |
JP (1) | JP3720055B2 (de) |
AT (1) | ATE281115T1 (de) |
CA (1) | CA2219353C (de) |
DE (1) | DE69633782T2 (de) |
WO (1) | WO1996033652A1 (de) |
Families Citing this family (85)
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US5694933A (en) * | 1995-04-28 | 1997-12-09 | Care Wise Medical Products Corporation | Apparatus and methods for determining spatial coordinates of radiolabelled tissue using gamma-rays and associated characteristic X-rays |
US6076009A (en) * | 1997-05-05 | 2000-06-13 | The University Of Michigan | Solid state beta-sensitive surgical probe |
US5916167A (en) * | 1997-10-10 | 1999-06-29 | Neoprobe Corporation | Surgical probe apparatus and system |
US5961458A (en) * | 1997-11-18 | 1999-10-05 | Carewise Medical Products Corporation | Minimally invasive surgical probe for tissue identification and retrieval and method of use |
US6484050B1 (en) * | 1997-11-18 | 2002-11-19 | Care Wise Medical Products Corporation | Minimally invasive surgical instrument for tissue identification, dislodgment and retrieval and methods of use |
US6207111B1 (en) | 1997-12-31 | 2001-03-27 | Pem Technologies, Inc. | System for describing the physical distribution of an agent in a patient |
US6496717B2 (en) * | 1998-10-06 | 2002-12-17 | University Of South Florida | Radio guided seed localization of imaged lesions |
US8114006B2 (en) * | 1998-10-06 | 2012-02-14 | University Of South Florida | Radio guided seed localization of imaged lesions |
FR2795526B1 (fr) * | 1999-06-22 | 2001-11-23 | Jean Maublant | Dispositif de detection et de localisation d'une source radioactive emettrice de rayonnements gamma, utilisation dudit dispositif |
US6362472B1 (en) | 1999-10-22 | 2002-03-26 | Ethicon Endo-Surgery, Inc. | Method for calibrating a radiation detection system |
US6512943B1 (en) | 2000-05-22 | 2003-01-28 | Wisconsin Alumni Research Foundation | Combined ultrasound-radionuclide device for percutaneous ultrasound-guided biopsy and method of use |
US20010048730A1 (en) * | 2000-06-06 | 2001-12-06 | Masumi Oshima | Method of highly sensitive analysis of nuclides by multiple gamma-ray detection |
US8489176B1 (en) | 2000-08-21 | 2013-07-16 | Spectrum Dynamics Llc | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US8909325B2 (en) | 2000-08-21 | 2014-12-09 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US7826889B2 (en) | 2000-08-21 | 2010-11-02 | Spectrum Dynamics Llc | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US8565860B2 (en) | 2000-08-21 | 2013-10-22 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system |
US8036731B2 (en) | 2001-01-22 | 2011-10-11 | Spectrum Dynamics Llc | Ingestible pill for diagnosing a gastrointestinal tract |
CA2435205A1 (en) | 2001-01-22 | 2002-08-01 | V-Target Technologies Ltd. | Ingestible device |
US6678546B2 (en) * | 2001-01-30 | 2004-01-13 | Fischer Imaging Corporation | Medical instrument guidance using stereo radiolocation |
US20050182015A1 (en) * | 2001-02-23 | 2005-08-18 | Ward Donna T. | Antisense modulation of EIF2C1 expression |
JP4031618B2 (ja) * | 2001-02-28 | 2008-01-09 | 安西メディカル株式会社 | 放射線源検出装置 |
US6432064B1 (en) | 2001-04-09 | 2002-08-13 | Ethicon Endo-Surgery, Inc. | Biopsy instrument with tissue marking element |
FR2823092B1 (fr) * | 2001-04-10 | 2004-03-05 | Eurorad 2 6 | Dispositif per-operatoire pour la localisation de tissus marques et procede utilisant un tel dispositif |
US6620111B2 (en) | 2001-04-20 | 2003-09-16 | Ethicon Endo-Surgery, Inc. | Surgical biopsy device having automatic rotation of the probe for taking multiple samples |
US20030013950A1 (en) * | 2001-06-27 | 2003-01-16 | David Rollo | Dual isotope studies in nuclear medicine imaging |
US20030036700A1 (en) * | 2001-07-20 | 2003-02-20 | Weinberg Irving N. | Internal/external coincident gamma camera system |
US6668277B1 (en) * | 2001-09-14 | 2003-12-23 | The Regents Of The University Of California | Web-based multi-channel analyzer |
EP1444955A1 (de) * | 2001-11-14 | 2004-08-11 | Noriyasu Sakamoto | Verfahren und vorrichtung zur spezifizierung von betroffenen teilen |
US6847838B1 (en) * | 2002-09-19 | 2005-01-25 | Southeastern Universities Research Assn., Inc. | Apparatus and method for high dose rate brachytherapy radiation treatment |
US20040116807A1 (en) * | 2002-10-17 | 2004-06-17 | Roni Amrami | Blood vessels wall imaging catheter |
AU2003276658A1 (en) * | 2002-11-04 | 2004-06-07 | V-Target Technologies Ltd. | Apparatus and methods for imaging and attenuation correction |
WO2006051531A2 (en) | 2004-11-09 | 2006-05-18 | Spectrum Dynamics Llc | Radioimaging |
US7176466B2 (en) * | 2004-01-13 | 2007-02-13 | Spectrum Dynamics Llc | Multi-dimensional image reconstruction |
US9470801B2 (en) | 2004-01-13 | 2016-10-18 | Spectrum Dynamics Llc | Gating with anatomically varying durations |
US7968851B2 (en) | 2004-01-13 | 2011-06-28 | Spectrum Dynamics Llc | Dynamic spect camera |
US9040016B2 (en) | 2004-01-13 | 2015-05-26 | Biosensors International Group, Ltd. | Diagnostic kit and methods for radioimaging myocardial perfusion |
WO2007010537A2 (en) | 2005-07-19 | 2007-01-25 | Spectrum Dynamics Llc | Reconstruction stabilizer and active vision |
US8571881B2 (en) | 2004-11-09 | 2013-10-29 | Spectrum Dynamics, Llc | Radiopharmaceutical dispensing, administration, and imaging |
US8586932B2 (en) | 2004-11-09 | 2013-11-19 | Spectrum Dynamics Llc | System and method for radioactive emission measurement |
US20050203331A1 (en) * | 2004-03-09 | 2005-09-15 | Szapucki Matthew P. | Neurosurgical instrument with gamma ray detector |
ATE421703T1 (de) * | 2004-05-10 | 2009-02-15 | Gfe Ges Fuer Forschungs Und En | Positionsbestimmende sonde für hochenergetische gammastrahlungen |
US7038205B2 (en) * | 2004-05-13 | 2006-05-02 | The Regents Of The University Of California | Probe apparatus with laser guiding for locating a source of radioactivity |
US7970455B2 (en) * | 2004-05-20 | 2011-06-28 | Spectrum Dynamics Llc | Ingestible device platform for the colon |
EP1778957A4 (de) | 2004-06-01 | 2015-12-23 | Biosensors Int Group Ltd | Optimierung der messung radioaktiver strahlung an besonderen körperstrukturen |
EP1766550A2 (de) | 2004-06-01 | 2007-03-28 | Spectrum Dynamics LLC | Verfahren zur ansichtsauswahl für messungen radioaktiver emission |
US7952079B2 (en) | 2004-08-12 | 2011-05-31 | Navotek Medical Ltd. | Localization of a radioactive source |
EP1805506A4 (de) | 2004-08-12 | 2010-06-02 | Navotek Medical Ltd | Lokalisierung einer radioaktiven quelle im körper einer person |
US8423125B2 (en) | 2004-11-09 | 2013-04-16 | Spectrum Dynamics Llc | Radioimaging |
US9316743B2 (en) | 2004-11-09 | 2016-04-19 | Biosensors International Group, Ltd. | System and method for radioactive emission measurement |
US8615405B2 (en) | 2004-11-09 | 2013-12-24 | Biosensors International Group, Ltd. | Imaging system customization using data from radiopharmaceutical-associated data carrier |
US9943274B2 (en) | 2004-11-09 | 2018-04-17 | Spectrum Dynamics Medical Limited | Radioimaging using low dose isotope |
WO2008059489A2 (en) | 2006-11-13 | 2008-05-22 | Spectrum Dynamics Llc | Radioimaging applications of and novel formulations of teboroxime |
US7872235B2 (en) | 2005-01-13 | 2011-01-18 | Spectrum Dynamics Llc | Multi-dimensional image reconstruction and analysis for expert-system diagnosis |
WO2007004269A1 (ja) * | 2005-06-30 | 2007-01-11 | Hamamatsu Photonics K.K. | 放射線検出器 |
US8837793B2 (en) | 2005-07-19 | 2014-09-16 | Biosensors International Group, Ltd. | Reconstruction stabilizer and active vision |
US8644910B2 (en) | 2005-07-19 | 2014-02-04 | Biosensors International Group, Ltd. | Imaging protocols |
CN101282760A (zh) | 2005-08-11 | 2008-10-08 | 纳沃特克医药有限公司 | 利用基于放射性的位置传感器的医疗系统和方法 |
EP1952180B1 (de) | 2005-11-09 | 2017-01-04 | Biosensors International Group, Ltd. | Dynamische spect-kamera |
DE102005063417B4 (de) * | 2005-12-23 | 2021-01-07 | Airbus Defence and Space GmbH | Antenne für eine hochauflösende Synthetik-Apertur-Radarvorrichtung |
WO2007074466A2 (en) | 2005-12-28 | 2007-07-05 | Starhome Gmbh | Late forwarding to local voicemail system of calls to roaming users |
US20070211965A1 (en) * | 2006-03-07 | 2007-09-13 | Helbing Rene P | Hand-held diagnostic systems and methods of use thereof |
US8894974B2 (en) | 2006-05-11 | 2014-11-25 | Spectrum Dynamics Llc | Radiopharmaceuticals for diagnosis and therapy |
US7601966B2 (en) | 2006-06-28 | 2009-10-13 | Spectrum Dynamics Llc | Imaging techniques for reducing blind spots |
WO2008075362A2 (en) | 2006-12-20 | 2008-06-26 | Spectrum Dynamics Llc | A method, a system, and an apparatus for using and processing multidimensional data |
JP5106928B2 (ja) * | 2007-06-14 | 2012-12-26 | オリンパス株式会社 | 画像処理装置および画像処理プログラム |
US8521253B2 (en) | 2007-10-29 | 2013-08-27 | Spectrum Dynamics Llc | Prostate imaging |
IL199900A0 (en) * | 2008-08-18 | 2010-04-15 | Michal Tune | Implantation device for soft tissue markers and other implants |
WO2010099137A2 (en) | 2009-02-26 | 2010-09-02 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the emt status of tumor cells in vivo |
JP5613235B2 (ja) * | 2009-07-20 | 2014-10-22 | コーニンクレッカ フィリップス エヌ ヴェ | 関心腫瘍領域の画成のための生体構造モデリング |
US8338788B2 (en) | 2009-07-29 | 2012-12-25 | Spectrum Dynamics Llc | Method and system of optimized volumetric imaging |
WO2012092394A1 (en) | 2010-12-29 | 2012-07-05 | Cardinal Health 414, Llc | Closed vial fill system for aseptic dispensing |
EP2701604A1 (de) * | 2011-04-27 | 2014-03-05 | Koninklijke Philips N.V. | Energieanwendungsvorrichtung |
US9417332B2 (en) * | 2011-07-15 | 2016-08-16 | Cardinal Health 414, Llc | Radiopharmaceutical CZT sensor and apparatus |
US20130102772A1 (en) | 2011-07-15 | 2013-04-25 | Cardinal Health 414, Llc | Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals-full |
WO2013012813A1 (en) | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc | Modular cassette synthesis unit |
CA2852981C (en) * | 2011-10-27 | 2023-03-07 | Atomic Energy Of Canada Limited / Energie Atomique Du Canada Limitee | Portable detection apparatus and method |
WO2013105519A1 (ja) * | 2012-01-13 | 2013-07-18 | 独立行政法人放射線医学総合研究所 | 放射性物質検出装置、放射線源位置可視化システム、および放射性物質検出方法 |
GB2520762B (en) * | 2013-12-02 | 2018-04-04 | Symetrica Ltd | Gamma-ray detector |
CN105105697B (zh) * | 2015-07-03 | 2017-10-10 | 西安电子科技大学 | 一种医用内窥式辐射发光成像系统及其成像方法 |
JP6838059B2 (ja) * | 2015-10-27 | 2021-03-03 | デビコー・メディカル・プロダクツ・インコーポレイテッドDevicor Medical Products, Inc. | 外科用プローブ装置、ならびにそれを使用するシステム及び方法 |
KR101818654B1 (ko) * | 2015-12-23 | 2018-01-16 | 한국과학기술원 | 내시경 기반 융합의료영상기기 |
US11452489B2 (en) * | 2017-10-02 | 2022-09-27 | Intuitive Surgical Operations, Inc. | Radiation finder tool |
GB201802113D0 (en) | 2018-02-09 | 2018-03-28 | Soletanche Freyssinet Sas | System for and method of surveying a surface |
US11047813B2 (en) | 2018-05-21 | 2021-06-29 | Volodymyr Pavlovich ROMBAKH | Non-invasive monitoring of atomic reactions to detect structural failure |
WO2020047835A1 (en) * | 2018-09-07 | 2020-03-12 | Shenzhen Xpectvision Technology Co., Ltd. | Systems and methods for imaging the thyroid |
Family Cites Families (26)
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US3936646A (en) * | 1972-06-30 | 1976-02-03 | Jonker Roelof R | Collimator kit |
US3843881A (en) * | 1973-01-11 | 1974-10-22 | Phillips Petroleum Co | Detection of elements by irradiating material and measuring scattered radiation at two energy levels |
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US4124804A (en) * | 1976-12-17 | 1978-11-07 | Stuart Mirell | Compton scatter scintillation camera system |
US4150289A (en) * | 1977-05-26 | 1979-04-17 | Magnaflux Corporation | Gamma ray calibration system |
US4340818A (en) * | 1980-05-14 | 1982-07-20 | The Board Of Trustees Of The University Of Alabama | Scanning grid apparatus for suppressing scatter in radiographic imaging |
US4419585A (en) * | 1981-02-26 | 1983-12-06 | Massachusetts General Hospital | Variable angle slant hole collimator |
US4489426A (en) * | 1981-12-23 | 1984-12-18 | General Electric Company | Collimator with adjustable aperture |
US4782840A (en) * | 1984-03-02 | 1988-11-08 | Neoprobe Corporation | Method for locating, differentiating, and removing neoplasms |
US4873632A (en) * | 1984-04-27 | 1989-10-10 | The Curators Of The University Of Missouri | Apparatus and methods for scatter reduction in radiation imaging |
US4665897A (en) * | 1984-05-25 | 1987-05-19 | Lemelson Jerome H | Composition and method for detecting and treating cancer |
US4682604A (en) * | 1985-02-25 | 1987-07-28 | The Regents Of The University Of California | Coincidence counting emission tomographic probe: method and apparatus |
GB8521287D0 (en) * | 1985-08-27 | 1985-10-02 | Frith B | Flow measurement & imaging |
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US4801803A (en) * | 1987-03-17 | 1989-01-31 | Neoprobe Corporation | Detector and localizer for low energy radiation emissions |
US4893013A (en) * | 1987-03-17 | 1990-01-09 | Neoprobe Corporation | Detector and localizer for low energy radiation emissions |
US5165410A (en) * | 1987-05-15 | 1992-11-24 | Medical & Scientific Enterprises, Inc. | Position indicating system for a multidiagnostic scanner |
US5003980A (en) * | 1988-03-11 | 1991-04-02 | The United States Of America As Represented By The United States Department Of Energy | Method and apparatus for measuring lung density by Compton backscattering |
US4995396A (en) * | 1988-12-08 | 1991-02-26 | Olympus Optical Co., Ltd. | Radioactive ray detecting endoscope |
US4959547A (en) * | 1989-06-08 | 1990-09-25 | Care Wise Medical Products Corporation | Apparatus and methods for detecting, localizing, and imaging of radiation in biological systems |
US5036210A (en) * | 1989-12-18 | 1991-07-30 | Gas Research Institute | Magnetically detectable plastic pipe |
US5068883A (en) * | 1990-05-11 | 1991-11-26 | Science Applications International Corporation | Hand-held contraband detector |
US5148040A (en) * | 1991-07-11 | 1992-09-15 | Care Wise Medical Products Corp. | Radiation blocking device and method of use with radiation detecting probe |
US5519221A (en) * | 1992-01-22 | 1996-05-21 | Ansel M. Schwartz | Dedicated apparatus and method for emission mammography |
US5694933A (en) * | 1995-04-28 | 1997-12-09 | Care Wise Medical Products Corporation | Apparatus and methods for determining spatial coordinates of radiolabelled tissue using gamma-rays and associated characteristic X-rays |
US5813985A (en) * | 1995-07-31 | 1998-09-29 | Care Wise Medical Products Corporation | Apparatus and methods for providing attenuation guidance and tumor targeting for external beam radiation therapy administration |
-
1995
- 1995-04-28 US US08/430,589 patent/US5694933A/en not_active Expired - Lifetime
-
1996
- 1996-04-19 JP JP53261296A patent/JP3720055B2/ja not_active Expired - Lifetime
- 1996-04-19 EP EP96912943A patent/EP0830079B1/de not_active Expired - Lifetime
- 1996-04-19 WO PCT/US1996/005479 patent/WO1996033652A1/en active IP Right Grant
- 1996-04-19 DE DE69633782T patent/DE69633782T2/de not_active Expired - Lifetime
- 1996-04-19 AT AT96912943T patent/ATE281115T1/de not_active IP Right Cessation
- 1996-04-19 CA CA002219353A patent/CA2219353C/en not_active Expired - Lifetime
-
1997
- 1997-10-27 US US08/958,417 patent/US6135955A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0830079A1 (de) | 1998-03-25 |
EP0830079B1 (de) | 2004-11-03 |
JPH11511239A (ja) | 1999-09-28 |
US6135955A (en) | 2000-10-24 |
JP3720055B2 (ja) | 2005-11-24 |
CA2219353C (en) | 2002-02-26 |
EP0830079A4 (de) | 1999-08-11 |
US5694933A (en) | 1997-12-09 |
ATE281115T1 (de) | 2004-11-15 |
WO1996033652A1 (en) | 1996-10-31 |
CA2219353A1 (en) | 1996-10-31 |
DE69633782T2 (de) | 2005-11-03 |
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