DE69629209D1 - Getrocknete zubereitung von bluttfaktoren, enthaltend trehalose - Google Patents
Getrocknete zubereitung von bluttfaktoren, enthaltend trehaloseInfo
- Publication number
- DE69629209D1 DE69629209D1 DE69629209T DE69629209T DE69629209D1 DE 69629209 D1 DE69629209 D1 DE 69629209D1 DE 69629209 T DE69629209 T DE 69629209T DE 69629209 T DE69629209 T DE 69629209T DE 69629209 D1 DE69629209 D1 DE 69629209D1
- Authority
- DE
- Germany
- Prior art keywords
- blood factor
- preparation containing
- dried blood
- containing trehalose
- factor preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9501040 | 1995-01-19 | ||
GBGB9501040.1A GB9501040D0 (en) | 1995-01-19 | 1995-01-19 | Dried composition |
PCT/GB1996/000119 WO1996022107A1 (en) | 1995-01-19 | 1996-01-19 | Dried blood factor composition comprising trehalose |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69629209D1 true DE69629209D1 (de) | 2003-08-28 |
DE69629209T2 DE69629209T2 (de) | 2004-02-19 |
Family
ID=10768253
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69629209T Expired - Lifetime DE69629209T2 (de) | 1995-01-19 | 1996-01-19 | Getrocknete zubereitung von bluttfaktoren, enthaltend trehalose |
DE69637749T Expired - Lifetime DE69637749D1 (de) | 1995-01-19 | 1996-01-19 | Getrocknete Blutfaktorzusammensetzung mit Trehalose |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637749T Expired - Lifetime DE69637749D1 (de) | 1995-01-19 | 1996-01-19 | Getrocknete Blutfaktorzusammensetzung mit Trehalose |
Country Status (15)
Country | Link |
---|---|
US (2) | US6649386B2 (de) |
EP (4) | EP0871476B1 (de) |
JP (1) | JP3898221B2 (de) |
KR (1) | KR100417593B1 (de) |
CN (1) | CN1152713C (de) |
AT (2) | ATE413885T1 (de) |
AU (1) | AU704317B2 (de) |
CA (2) | CA2210872C (de) |
DE (2) | DE69629209T2 (de) |
DK (2) | DK1308170T3 (de) |
ES (2) | ES2316658T3 (de) |
GB (1) | GB9501040D0 (de) |
PT (2) | PT871476E (de) |
SI (1) | SI1308170T1 (de) |
WO (1) | WO1996022107A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US7244824B2 (en) * | 1995-01-19 | 2007-07-17 | Quadrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
US6964771B1 (en) | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
US6632648B1 (en) * | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
GB9616536D0 (en) | 1996-08-06 | 1996-09-25 | Quadrant Holdings Cambridge | Co-amoxiclav dosage form |
AUPO871997A0 (en) * | 1997-08-25 | 1997-09-18 | Csl Limited | Dried biologically or therapeutically active preparations |
CA2634663C (en) | 1999-02-22 | 2009-08-25 | University Of Connecticut | Novel albumin-free factor viii formulations |
BR0211842A (pt) * | 2001-08-10 | 2004-08-31 | Hayashibara Biochem Lab | Associado, processos para produzir um associado de trealose ou maltitol e um ou mais compostos de ìon metálico, um produto em pó e um alimento marinho seco, método para formar um associado de trealose ou maltitol e um ou mais compostos de ìon metálico, composição, produto em pó, agente e tempero para alimentos |
JP2007505147A (ja) | 2003-09-12 | 2007-03-08 | アンティジェニクス インコーポレーテッド | 単純ヘルペスウイルス感染の治療および予防用ワクチン |
WO2005094873A1 (en) * | 2004-03-19 | 2005-10-13 | Baxter International Inc. | Factor ixa for the treatment of bleeding disorders |
EP1758937B1 (de) | 2004-05-24 | 2009-09-02 | Genvault Corporation | Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form |
KR100624013B1 (ko) | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
US8133484B2 (en) | 2006-12-15 | 2012-03-13 | Lifebond Ltd | Hemostatic materials and dressing |
CA2673260A1 (en) * | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | Factor vii and viia compositions |
EP1958618A1 (de) * | 2007-02-15 | 2008-08-20 | Octapharma AG | Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren |
CA2991162A1 (en) * | 2007-12-21 | 2009-07-02 | Aptevo Biotherapeutics Llc | Stabilized factor ix formulations containing trehalose |
US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
TWI515006B (zh) * | 2007-12-28 | 2016-01-01 | 巴克斯特國際公司 | 重組vwf調配物 |
CN102177237B (zh) | 2008-09-12 | 2013-10-30 | 金沃特公司 | 用于贮存和稳定生物分子的基质和介质 |
BRPI0919693A2 (pt) | 2008-10-21 | 2020-08-11 | Baxter Healthcare S.A | formulação farmacêutica estável liofilizada |
JP5779780B2 (ja) | 2008-11-07 | 2015-09-16 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第viii因子製剤 |
BR112012015029A2 (pt) | 2009-12-22 | 2017-06-27 | Lifebond Ltd | matriz reticulada, método para controlar a formação de uma matriz, método ou matriz, método para vedar um tecido contra vazamento de um fluído corporal, agente hemostático ou vedante cirúrgico, composição para vedar um ferimento, uso da composição, composição para um veículo para entrega localizada de fármaco, composição para engenharia de tecido, e método para modificar uma composição |
EP2732262A4 (de) * | 2011-07-13 | 2014-12-10 | Denator Ab | Verfahren zur stabilisierung von flüssigen biologischen proben |
CN102416171B (zh) * | 2011-12-06 | 2013-12-25 | 中国医学科学院输血研究所 | 高纯度凝血酶原复合物制品干热病毒灭活过程中的保护剂 |
US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US20160317646A1 (en) * | 2013-12-19 | 2016-11-03 | Crucell Holland B.V. | Formulations for virosomes |
MX2017000862A (es) | 2014-08-04 | 2017-05-01 | Csl Ltd | Formulacion de factor viii. |
EA201792501A1 (ru) | 2015-05-13 | 2018-10-31 | Эйдженус Инк. | Вакцины для лечения и профилактики рака |
CN107333750A (zh) * | 2017-06-11 | 2017-11-10 | 成都吱吖科技有限公司 | 一种长时血液细胞稳定剂 |
JP2021522239A (ja) | 2018-04-26 | 2021-08-30 | アジェナス インコーポレイテッド | 熱ショックタンパク質結合ペプチド組成物およびその使用方法 |
WO2021001522A1 (en) | 2019-07-04 | 2021-01-07 | CSL Behring Lengnau AG | A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii |
EP4240757A2 (de) | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Reinigung von fviii aus plasma mittels siliciumoxidadsorption |
WO2022261716A1 (en) * | 2021-06-16 | 2022-12-22 | Exopharm Limited | Aqueous formulations for preservation of extracellular vesicles |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4361509A (en) | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4495175A (en) * | 1982-08-05 | 1985-01-22 | University Of Rochester | Preparation of highly purified human antihemophilic factor |
FI86885C (fi) | 1984-04-20 | 1992-10-26 | Genentech Inc | Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill |
EP0182448A3 (de) | 1984-08-24 | 1987-10-28 | Genetics Institute, Inc. | Verfahren zur Herstellung von Faktor VIII und verwandte Produkte |
DE3682047D1 (de) * | 1985-07-09 | 1991-11-21 | Quadrant Bioresources Ltd | Beschuetzung von proteinen und aehnlichem. |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
CA1329760C (en) * | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
CA2051092C (en) * | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
US5288853A (en) | 1992-04-30 | 1994-02-22 | Alpha Therapeutic Corporation | Factor viii purification process |
WO1994007510A1 (en) * | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
WO1995003332A1 (en) | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
US5955448A (en) | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
CA2634663C (en) | 1999-02-22 | 2009-08-25 | University Of Connecticut | Novel albumin-free factor viii formulations |
-
1995
- 1995-01-19 GB GBGB9501040.1A patent/GB9501040D0/en active Pending
-
1996
- 1996-01-19 ES ES03002147T patent/ES2316658T3/es not_active Expired - Lifetime
- 1996-01-19 AT AT03002147T patent/ATE413885T1/de active
- 1996-01-19 AU AU44540/96A patent/AU704317B2/en not_active Expired
- 1996-01-19 CN CNB961926600A patent/CN1152713C/zh not_active Expired - Lifetime
- 1996-01-19 DE DE69629209T patent/DE69629209T2/de not_active Expired - Lifetime
- 1996-01-19 DK DK03002147T patent/DK1308170T3/da active
- 1996-01-19 EP EP96900633A patent/EP0871476B1/de not_active Expired - Lifetime
- 1996-01-19 AT AT96900633T patent/ATE245442T1/de active
- 1996-01-19 EP EP03002147A patent/EP1308170B1/de not_active Expired - Lifetime
- 1996-01-19 CA CA002210872A patent/CA2210872C/en not_active Expired - Lifetime
- 1996-01-19 DK DK96900633T patent/DK0871476T3/da active
- 1996-01-19 WO PCT/GB1996/000119 patent/WO1996022107A1/en active IP Right Grant
- 1996-01-19 SI SI9630765T patent/SI1308170T1/sl unknown
- 1996-01-19 DE DE69637749T patent/DE69637749D1/de not_active Expired - Lifetime
- 1996-01-19 ES ES96900633T patent/ES2202425T3/es not_active Expired - Lifetime
- 1996-01-19 KR KR1019970704891A patent/KR100417593B1/ko not_active IP Right Cessation
- 1996-01-19 PT PT96900633T patent/PT871476E/pt unknown
- 1996-01-19 JP JP52213396A patent/JP3898221B2/ja not_active Expired - Fee Related
- 1996-01-19 EP EP10008828A patent/EP2258402A3/de not_active Withdrawn
- 1996-01-19 EP EP08010169A patent/EP1974741A1/de not_active Withdrawn
- 1996-01-19 CA CA2671383A patent/CA2671383C/en not_active Expired - Lifetime
- 1996-01-19 US US08/875,796 patent/US6649386B2/en not_active Expired - Lifetime
- 1996-01-19 PT PT03002147T patent/PT1308170E/pt unknown
-
2009
- 2009-02-13 US US12/371,459 patent/US7803911B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: QUADRANT DRUG DELIVERY LTD., RUDDINGTON, NOTTINGHA |
|
8364 | No opposition during term of opposition |