DE69621608T2 - Vorrichtung und verfahren für kapillarelektrophorese - Google Patents

Vorrichtung und verfahren für kapillarelektrophorese

Info

Publication number
DE69621608T2
DE69621608T2 DE69621608T DE69621608T DE69621608T2 DE 69621608 T2 DE69621608 T2 DE 69621608T2 DE 69621608 T DE69621608 T DE 69621608T DE 69621608 T DE69621608 T DE 69621608T DE 69621608 T2 DE69621608 T2 DE 69621608T2
Authority
DE
Germany
Prior art keywords
capillary electrophoresis
electrophoresis
capillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69621608T
Other languages
English (en)
Other versions
DE69621608D1 (de
Inventor
Jonathan Briggs
M Mccormick
W Hoyt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Publication of DE69621608D1 publication Critical patent/DE69621608D1/de
Application granted granted Critical
Publication of DE69621608T2 publication Critical patent/DE69621608T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44782Apparatus specially adapted therefor of a plurality of samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/06Test-tube stands; Test-tube holders
    • B01L9/065Test-tube stands; Test-tube holders specially adapted for capillary tubes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
DE69621608T 1995-03-21 1996-03-20 Vorrichtung und verfahren für kapillarelektrophorese Expired - Fee Related DE69621608T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/408,683 US5560811A (en) 1995-03-21 1995-03-21 Capillary electrophoresis apparatus and method
PCT/US1996/003828 WO1996029595A1 (en) 1995-03-21 1996-03-20 Capillary electrophoresis apparatus and method

Publications (2)

Publication Number Publication Date
DE69621608D1 DE69621608D1 (de) 2002-07-11
DE69621608T2 true DE69621608T2 (de) 2003-02-06

Family

ID=23617310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621608T Expired - Fee Related DE69621608T2 (de) 1995-03-21 1996-03-20 Vorrichtung und verfahren für kapillarelektrophorese

Country Status (7)

Country Link
US (1) US5560811A (de)
EP (2) EP0815440B1 (de)
JP (1) JPH11502618A (de)
AU (1) AU715852B2 (de)
CA (1) CA2215974A1 (de)
DE (1) DE69621608T2 (de)
WO (1) WO1996029595A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007005323A1 (de) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Absaugeinrichtung
DE102006058575B4 (de) * 2005-12-12 2009-01-15 Combisep Inc., Ames Multiplex-CE-Fluoreszenzsystem

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
CA2192262C (en) * 1995-12-08 2011-03-15 Yoshihide Hayashizaki Method for purification and transfer to separation/detection systems of dna sequencing samples and plates used therefor
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US20060141539A1 (en) * 1996-05-30 2006-06-29 Taylor D L Miniaturized cell array methods and apparatus for cell-based screening
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
AU726987B2 (en) 1996-06-28 2000-11-30 Caliper Life Sciences, Inc. Electropipettor and compensation means for electrophoretic bias
BR9710054A (pt) 1996-06-28 2000-01-11 Caliper Techn Corp Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.
EP0864860A1 (de) * 1997-03-10 1998-09-16 Japan Science and Technology Corporation Probenplatte und Vielfachkapillarelektrophoresegerät
KR100351531B1 (ko) * 1997-04-25 2002-09-11 캘리퍼 테크놀로지스 코포레이션 기하형상이 개선된 채널을 채용하는 미소 유체 장치
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
JP4276301B2 (ja) * 1997-05-16 2009-06-10 エグザクト サイエンシーズ コーポレイション 固定化プローブを用いる、分子の電気泳動分析
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US7019827B2 (en) * 1997-06-16 2006-03-28 Diversa Corporation GigaMatrix holding tray having through-hole wells
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
WO1999054711A1 (en) 1998-04-17 1999-10-28 Ljl Biosystems, Inc. Sample-holding devices and systems
US6207031B1 (en) 1997-09-15 2001-03-27 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
GB9719673D0 (en) 1997-09-17 1997-11-19 Glaxo Group Ltd Novel apparatus
EP1019712A4 (de) * 1997-09-19 2002-08-07 Aclara Biosciences Inc Vorrichtung und verfahren zur kapillarströmung mit einem elektrischen feld
WO1999015876A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
ATE477850T1 (de) 1998-01-12 2010-09-15 Massachusetts Inst Technology Vorrichtung zur mikrotestdurchführung
US6990221B2 (en) * 1998-02-07 2006-01-24 Biodiscovery, Inc. Automated DNA array image segmentation and analysis
US6349144B1 (en) * 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
US6560859B1 (en) * 1998-02-16 2003-05-13 The Institute Of Physical And Chemical Research Shimadzu Corporation Capillary cassette and method of producing the same
US6475361B1 (en) 1998-02-20 2002-11-05 Tetragen Sa Capillary electrophoresis apparatus having filling/refilling system and methods for use thereof
US6103083A (en) * 1998-02-20 2000-08-15 Tetragen Capillary electrophoresis apparatus and method
US6350618B1 (en) 1998-04-27 2002-02-26 Corning Incorporated Redrawn capillary imaging reservoir
EP0955084B1 (de) * 1998-04-27 2006-07-26 Corning Incorporated Verfahren zur Ablage von biologischen Proben mit hilfe eines nachgezogenen Kapillar-speichers
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
JP2002518026A (ja) * 1998-06-19 2002-06-25 エムティー テクノロジー, インコーポレイテッド Srprnaを用いる非ウイルス生物の検出
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
US6551557B1 (en) 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6151969A (en) * 1998-07-14 2000-11-28 Southwest Research Institute Electromechanical and electrochemical impedance spectroscopy for measuring and imaging fatigue damage
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6638716B2 (en) 1998-08-24 2003-10-28 Therasense, Inc. Rapid amperometric verification of PCR amplification of DNA
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6103199A (en) * 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
EP0999443A3 (de) * 1998-11-02 2002-09-18 The Institute of Physical and Chemical Research Kapillarelektroforesesvorrichtung, Probenplatte, und Probeneinspritzverfahren
EP1006355A3 (de) * 1998-11-30 2000-11-08 The Institute of Physical and Chemical Research Kapillarelektrophoresegerät
US6270644B1 (en) 1999-01-27 2001-08-07 Affymetrix, Inc. Capillary array electrophoresis scanner
MXPA01007804A (es) * 1999-02-02 2003-06-09 Caliper Techn Corp Metodos, dispositivos y sistemas para caracterizar proteinas.
US6389197B1 (en) 1999-02-10 2002-05-14 California Institute Of Technology Coupling system to a microsphere cavity
DE60043233D1 (de) 1999-02-18 2009-12-10 Corning Inc Durch extrusion von siliziumdioxid erhaltene wabenstruktur aus titanhaltigem quarzglas
EP1156988A4 (de) 1999-02-18 2004-11-17 Corning Inc Verfahren zur herstellung einer wabenförmigen quarzglass-struktur durch extrudieren von siliciumdioxid-russ
AU3708300A (en) * 1999-02-26 2000-09-14 Exact Sciences Corporation Methods for purifying dna using immobilized capture probes
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
US6027873A (en) * 1999-03-19 2000-02-22 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
CN1348396A (zh) 1999-03-19 2002-05-08 金克克国际有限公司 用于高效筛选的多通孔测试板
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6682887B1 (en) 1999-04-30 2004-01-27 Aclara Biosciences, Inc. Detection using degradation of a tagged sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
WO2000067009A1 (en) * 1999-04-30 2000-11-09 Applied Hydrogel Technology Corporation Mixed buffers in gel electrophoresis systems
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
JP4159702B2 (ja) * 1999-05-12 2008-10-01 独立行政法人理化学研究所 キャピラリーカラムへのゲル充填装置
US6533914B1 (en) * 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US6423536B1 (en) 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
JP2003507715A (ja) * 1999-08-13 2003-02-25 カーティージャン テクノロジーズ、 インコーポレイテッド 液体試料取扱い装置
GB2368640B (en) * 1999-08-13 2003-09-17 Cartesian Technologies Inc Apparatus for liquid sample handling
JP2004500552A (ja) * 1999-09-21 2004-01-08 ゲノム セラピューティックス コーポレーション 液体処理、サーマルサイクリング及び精製を統合した迅速なdna試料処理のための装置
US6572752B1 (en) * 1999-09-29 2003-06-03 Hitachi, Ltd. Capillary electrophoretic instrument and capillary array assembly
US7099502B2 (en) * 1999-10-12 2006-08-29 Biodiscovery, Inc. System and method for automatically processing microarrays
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US6620625B2 (en) 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US20010055765A1 (en) * 2000-02-18 2001-12-27 O'keefe Matthew Apparatus and methods for parallel processing of micro-volume liquid reactions
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
FR2812942B1 (fr) * 2000-08-08 2002-10-31 Commissariat Energie Atomique Dispositif d'imagerie de fluorescence en lumiere polarisee
EP1186886A3 (de) * 2000-09-04 2004-01-07 Fuji Photo Film Co., Ltd. Verfahren zur biochemischen Analyse und dazu geeignetes Gerät
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
WO2002061858A2 (en) 2000-11-17 2002-08-08 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20040168728A1 (en) * 2000-12-18 2004-09-02 Andreas Schober Device for receiving and discharging liquid substances
DE60220497T2 (de) 2001-01-26 2008-01-31 Biocal Technology, Inc., Irvine Optische detektion in einem mehrkanaligen bioseparationssystem
ATE522802T1 (de) * 2001-01-26 2011-09-15 Qiagen Sciences Llc Mehrkanalkassette für biotrennung
WO2002095356A2 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
US20040074931A1 (en) * 2001-05-22 2004-04-22 Coffelt, Jr. Louis Arthur Dual microliter dosage system
AU2002344221A1 (en) * 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
DE10127045C2 (de) * 2001-06-02 2003-10-30 November Ag Molekulare Medizin Verfahren zum Nachweis einer Substanz und Mikrotiterplatte
US6929779B2 (en) 2001-06-22 2005-08-16 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation output
US6932940B2 (en) * 2001-06-22 2005-08-23 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation input
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
SG187992A1 (en) 2001-07-25 2013-03-28 Univ Princeton Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US7390463B2 (en) * 2001-09-07 2008-06-24 Corning Incorporated Microcolumn-based, high-throughput microfluidic device
US20030062833A1 (en) * 2001-10-03 2003-04-03 Wen-Yen Tai Mini-type decorative bulb capable of emitting light through entire circumferential face
US6870165B2 (en) 2001-10-19 2005-03-22 Biocal Technology, Inc. Multi-color multiplexed analysis in a bio-separation system
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US20030104512A1 (en) * 2001-11-30 2003-06-05 Freeman Alex R. Biosensors for single cell and multi cell analysis
WO2003062815A1 (en) * 2002-01-18 2003-07-31 Biocal Technology, Inc. Multi-segment cartridge for bio-separation with multiplexed fluorescence detection
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US7512496B2 (en) * 2002-09-25 2009-03-31 Soheil Shams Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays
CA2500936C (en) * 2002-09-30 2012-10-30 Nimblegen Systems, Inc. Parallel loading of arrays
US6939450B2 (en) * 2002-10-08 2005-09-06 Abbott Laboratories Device having a flow channel
DE10251669B3 (de) * 2002-11-06 2004-06-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kapillarsubstrat zur Tieftemperaturspeicherung von Suspensionsproben
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US7534335B2 (en) * 2003-02-28 2009-05-19 Combisep, Inc. Multiplexed, absorbance-based capillary electrophoresis system and method
US6833062B2 (en) * 2003-02-28 2004-12-21 Combisep, Inc. Multiplexed, absorbance-based capillary electrophoresis system and method
FR2853565A1 (fr) * 2003-04-11 2004-10-15 Commissariat Energie Atomique Microdispositif de transfert collectif d'une pluralite de liquide
US7858387B2 (en) * 2003-04-30 2010-12-28 Perkinelmer Health Sciences, Inc. Method of scanning a sample plate surface mask in an area adjacent to a conductive area using matrix-assisted laser desorption and ionization mass spectrometry
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
WO2005019470A2 (en) * 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20050072674A1 (en) * 2003-10-03 2005-04-07 Agencourt Bioscience Corporation Method and device for introducing a sample into an electrophoretic apparatus
CA2543830A1 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
WO2005047882A2 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8030092B2 (en) * 2003-11-07 2011-10-04 Princeton Biochemicals, Inc. Controlled electrophoresis method
EP1735097B1 (de) 2004-03-12 2016-11-30 Life Technologies Corporation Ladung eines nanoliter-arrays
KR100777172B1 (ko) * 2004-06-07 2007-11-28 나노 퓨전 가부시키가이샤 전기 침투류 펌프 시스템 및 전기 침투류 펌프
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
JP4457919B2 (ja) * 2005-02-28 2010-04-28 株式会社島津製作所 電気泳動プレート
JP4507922B2 (ja) * 2005-03-09 2010-07-21 株式会社島津製作所 キャピラリープレートを用いた試料注入方法
US20060201868A1 (en) * 2005-03-11 2006-09-14 Simmons Blake A Methods and devices for high-throughput dielectrophoretic concentration
KR100930255B1 (ko) * 2005-03-30 2009-12-09 나노 퓨전 가부시키가이샤 전기 침투류 펌프 및 액체 공급 장치
JP2006275016A (ja) * 2005-03-30 2006-10-12 Science Solutions International Laboratory Inc 液体輸送装置及び液体輸送システム
US8261598B2 (en) * 2006-03-09 2012-09-11 Agency For Science, Technology And Research Apparatus for performing a reaction in a droplet and method of using the same
US9892650B2 (en) * 2006-09-11 2018-02-13 Houghton Mifflin Harcourt Publishing Company Recovery of polled data after an online test platform failure
US9874501B2 (en) 2006-11-24 2018-01-23 Curiox Biosystems Pte Ltd. Use of chemically patterned substrate for liquid handling, chemical and biological reactions
WO2008063135A1 (en) * 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
AU2008232616B2 (en) * 2007-03-28 2014-08-07 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US8278047B2 (en) 2007-10-01 2012-10-02 Nabsys, Inc. Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment
US7825337B2 (en) * 2007-10-23 2010-11-02 Slam Brands, Inc. Cable management apparatuses and systems
WO2013114217A1 (en) 2012-02-05 2013-08-08 Curiox Biosystems Pte Ltd. Array plates and methods for making and using same
US10725020B2 (en) 2007-11-14 2020-07-28 Curiox Biosystems Pte Ltd. High throughput miniaturized assay system and methods
WO2010028140A2 (en) 2008-09-03 2010-03-11 Nabsys, Inc. Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8455260B2 (en) 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
US8784752B2 (en) 2009-04-17 2014-07-22 Curiox Biosystems Pte Ltd Use of chemically patterned substrate for liquid handling, chemical and biological reactions
US8246799B2 (en) 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
CA2772606A1 (en) 2009-09-01 2011-03-10 Oregon Health & Science University Reversible current gel electrophoresis device for separating biological macromolecules
WO2012011877A2 (en) 2010-07-23 2012-01-26 Curiox Biosystems Pte Ltd Apparatus and method for multiple reactions in small volumes
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
US8961764B2 (en) 2010-10-15 2015-02-24 Lockheed Martin Corporation Micro fluidic optic design
WO2012067911A1 (en) 2010-11-16 2012-05-24 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US10294516B2 (en) 2013-01-18 2019-05-21 Nabsys 2.0 Llc Enhanced probe binding
US9557318B2 (en) 2013-07-09 2017-01-31 Curiox Biosystems Pte Ltd. Array plates for washing samples
US20150093757A1 (en) * 2013-09-27 2015-04-02 Protein Simple Methods. apparatus and systems for detection of total protein using capillary electrophoresis
JP5941092B2 (ja) * 2014-04-14 2016-06-29 アークレイ株式会社 分析装置および分析方法
US10545139B2 (en) 2015-06-16 2020-01-28 Curiox Biosystems Pte Ltd. Methods and devices for performing biological assays using magnetic components
KR102446247B1 (ko) 2017-04-05 2022-09-21 큐리옥스 바이오시스템즈 피티이 엘티디. 어레이 플레이트 상의 샘플을 세정하기 위한 방법, 디바이스 및 장치
US11099117B2 (en) 2017-12-28 2021-08-24 ChandlerTec Inc. Apparatus and methods for sample acquisition
US10490482B1 (en) * 2018-12-05 2019-11-26 Toyota Motor Engineering & Manufacturing North America, Inc. Cooling devices including jet cooling with an intermediate mesh and methods for using the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6113148A (ja) * 1984-06-29 1986-01-21 Hitachi Ltd 連続型核酸断片電気泳動装置
US4925629A (en) * 1988-07-28 1990-05-15 Bioquant, Inc. Diagnostic device
FR2636140B1 (fr) * 1988-09-06 1990-10-12 Bertin & Cie Automate de separation de macromolecules ou de fragments de celles-ci
US5219528A (en) * 1989-07-28 1993-06-15 Pierce Chemical Company Apparatus for rapid immunoassays
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
DE4139211C2 (de) * 1990-11-30 1994-03-24 Hitachi Ltd Elektrophoresegerät
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
US5338427A (en) * 1993-02-26 1994-08-16 Biometric Imaging Inc. Single use separation cartridge for a capillary electrophoresis instrument
US5356525A (en) * 1993-04-16 1994-10-18 Beckman Instruments, Inc. Sample handling system
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
US5332480A (en) * 1993-06-16 1994-07-26 University Of Iowa Research Foundation Capillary bed electrophoresis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006058575B4 (de) * 2005-12-12 2009-01-15 Combisep Inc., Ames Multiplex-CE-Fluoreszenzsystem
DE102007005323A1 (de) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Absaugeinrichtung

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EP0815440A1 (de) 1998-01-07
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CA2215974A1 (en) 1996-09-26
US5560811A (en) 1996-10-01
AU5318796A (en) 1996-10-08
DE69621608D1 (de) 2002-07-11
WO1996029595A1 (en) 1996-09-26
JPH11502618A (ja) 1999-03-02
AU715852B2 (en) 2000-02-10

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