DE69528058T2 - Bmp-9 zusammensetzungen - Google Patents
Bmp-9 zusammensetzungenInfo
- Publication number
- DE69528058T2 DE69528058T2 DE69528058T DE69528058T DE69528058T2 DE 69528058 T2 DE69528058 T2 DE 69528058T2 DE 69528058 T DE69528058 T DE 69528058T DE 69528058 T DE69528058 T DE 69528058T DE 69528058 T2 DE69528058 T2 DE 69528058T2
- Authority
- DE
- Germany
- Prior art keywords
- bmp
- compositions
- proteins
- bone
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000037280 Growth Differentiation Factor 2 Human genes 0.000 title abstract 2
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dental Preparations (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/254,353 US6287816B1 (en) | 1991-06-25 | 1994-06-06 | BMP-9 compositions |
PCT/US1995/007084 WO1995033830A1 (en) | 1994-06-06 | 1995-06-05 | Bmp-9 compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69528058D1 DE69528058D1 (de) | 2002-10-10 |
DE69528058T2 true DE69528058T2 (de) | 2003-05-28 |
Family
ID=22963968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69528058T Expired - Fee Related DE69528058T2 (de) | 1994-06-06 | 1995-06-05 | Bmp-9 zusammensetzungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US6287816B1 (de) |
EP (2) | EP1230930A3 (de) |
JP (1) | JP3706133B2 (de) |
KR (1) | KR100255417B1 (de) |
AT (1) | ATE223486T1 (de) |
AU (1) | AU709869B2 (de) |
DE (1) | DE69528058T2 (de) |
WO (1) | WO1995033830A1 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5656593A (en) * | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
JP3504263B2 (ja) | 1991-11-04 | 2004-03-08 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法 |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
CA2280931C (en) | 1997-02-07 | 2009-05-05 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
EP0980252B1 (de) | 1997-05-05 | 2004-10-06 | Curis, Inc. | Therapien zur behandlung von akutem nierenversagen |
CA2291514C (en) | 1997-05-30 | 2011-07-12 | Creative Biomolecules, Inc. | Methods for evaluating tissue morphogenesis and activity |
US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
AU1616700A (en) * | 1998-11-13 | 2000-06-05 | Curis, Inc. | Methods of alleviating cancer symptoms |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
JP2003508493A (ja) * | 1999-09-08 | 2003-03-04 | ジェネティックス・インスチチュート・インコーポレーテッド | Bmp−9組成物およびコリン作動性ニューロンの分化誘導方法 |
US6723334B1 (en) * | 2000-03-01 | 2004-04-20 | Iowa State University Research Foundation, Inc. | Biologically compatible bone cements and orthopedic methods |
WO2002077006A1 (en) * | 2001-03-23 | 2002-10-03 | Human Genome Sciences, Inc. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
JP2004521128A (ja) * | 2001-02-23 | 2004-07-15 | ワイス | Bmpによるヒト骨髄由来cd105+細胞の軟骨形成能 |
ATE393573T1 (de) * | 2001-06-01 | 2008-05-15 | Wyeth Corp | Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
EP1504033A2 (de) | 2002-05-03 | 2005-02-09 | Millenium Biologix Inc. | Bindegewebe stimulierende peptide |
MXPA04011337A (es) * | 2002-05-17 | 2005-07-01 | Wyeth Corp | Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas. |
CA2520460A1 (en) * | 2003-03-27 | 2004-10-14 | Children's Hospital Medical Center | Use of fgf- 18 protein, target proteins and their respective encoding nucleotide sequences to induce cartilage formation |
CN1878565B (zh) | 2003-09-12 | 2011-01-12 | 惠氏公司 | 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂 |
PT1737734E (pt) | 2004-03-10 | 2010-11-11 | Scil Technology Gmbh | Implantes revestidos, seu fabrico e utilização |
CA2567405A1 (en) | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
ES2561048T3 (es) | 2004-07-23 | 2016-02-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
EP1863518A2 (de) * | 2005-03-30 | 2007-12-12 | Wyeth | VERFAHREN ZUR STIMULATION DES WAARWACHSTUMS MITTELS VERABREICHUNG VON BMPs |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
KR20160137665A (ko) | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
EP2035030A2 (de) | 2006-05-17 | 2009-03-18 | Stryker Corporation | Verwendung löslicher morphogener proteinkomplexe zur behandlung von knorpeldefekten |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
ES2447516T3 (es) | 2006-12-21 | 2014-03-12 | Stryker Corporation | Formulaciones de liberación sostenida que comprenden cristales BMP-7 |
AU2008211007B2 (en) | 2007-02-01 | 2013-09-19 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for treating or preventing breast cancer |
TW202021980A (zh) | 2007-02-02 | 2020-06-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
CA3039330C (en) | 2007-02-09 | 2021-11-09 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth in cancer patients |
DE102007006843A1 (de) | 2007-02-12 | 2008-08-14 | Bioregeneration Gmbh | Verfahren und Stützstruktur zum Kultivieren lebender Zellen |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
JP5323832B2 (ja) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 酸性水溶液中にgdf−5を含むタンパク質製剤 |
CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
JP2011514331A (ja) | 2008-02-13 | 2011-05-06 | キース フルスカ, | 血管硬化症の治療における使用のためのbmp−7 |
CA2720845A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
JP5922928B2 (ja) | 2008-08-14 | 2016-05-24 | アクセルロン ファーマ, インコーポレイテッド | 赤血球レベルを高めるためのgdfトラップの使用 |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
EP2387412A4 (de) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | Verfahren zur erhöhung des adiponectin-spiegels |
CA2752157A1 (en) | 2009-02-12 | 2010-08-19 | Stryker Corporation | Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease |
JP5819734B2 (ja) | 2009-02-12 | 2015-11-24 | ストライカー コーポレイションStryker Corporation | TGF−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法 |
WO2010110974A1 (en) | 2009-03-24 | 2010-09-30 | Stryker Corporation | Methods and compositions for tissue engineering |
EP2440576A4 (de) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | Verfahren zur erhöhung der zahl thermogener adipozyten |
AU2010263182B2 (en) | 2009-06-12 | 2016-05-12 | Acceleron Pharma Inc. | Truncated ActRIIB-Fc fusion proteins |
WO2011031856A1 (en) | 2009-09-09 | 2011-03-17 | Stryker Corporation | Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint |
AU2010292203A1 (en) * | 2009-09-09 | 2012-04-12 | Acceleron Pharma Inc. | ActRIIb antagonists and dosing and uses thereof |
ES2387379T3 (es) | 2009-09-17 | 2012-09-21 | Stryker Corporation | Tampones para controlar el pH de las proteínas morfogenéticas óseas |
US20110129469A1 (en) * | 2009-11-03 | 2011-06-02 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
CA2781152A1 (en) * | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
EP2516456A1 (de) | 2009-12-22 | 2012-10-31 | Stryker Corporation | Bmp-7-varianten mit reduzierter immunogenität |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
PE20140135A1 (es) | 2010-08-20 | 2014-02-20 | Wyeth Llc | Proteina osteogenicas de diseno |
CA2817008A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
JP2013542837A (ja) | 2010-11-15 | 2013-11-28 | ジンマー オーソバイオロジクス,インコーポレイティド | 骨空隙充填剤 |
US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
WO2014015109A1 (en) * | 2012-07-20 | 2014-01-23 | The Regents Of The University Of California | Methods for producing cartilage and bone |
US9833481B2 (en) * | 2012-09-01 | 2017-12-05 | Ken Muneoka | Method for articular cartilage and joint formation |
ES2884095T3 (es) | 2012-11-02 | 2021-12-10 | Celgene Corp | Antagonistas de activina-actrii y usos para el tratamiento de trastornos óseos y otros trastornos |
WO2015056093A1 (en) * | 2013-10-17 | 2015-04-23 | joint Center for Biosciences | Bioactive recombinant bmp-9 protein, mb109, expressed and isolated from bacteria |
BR122023023170A2 (pt) | 2014-06-13 | 2024-02-20 | Acceleron Pharma Inc. | Uso de um antagonista de actrii no tratamento ou prevenção de úlcera cutânea associada com beta-talassemia |
GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
MD4801C1 (ro) | 2014-12-03 | 2022-10-31 | Celgene Corporation | Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice |
PE20180041A1 (es) | 2015-06-05 | 2018-01-09 | Novartis Ag | Anticuerpos dirigidos a la proteina morfogenetica osea (bmp9) y metodos a partir de estos |
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---|---|---|---|---|
US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
US4294753A (en) | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
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US4795804A (en) | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
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US4681763A (en) | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
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US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
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US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US4968590A (en) | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
US5108753A (en) | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
EP1225225A3 (de) | 1988-04-08 | 2003-01-08 | Stryker Corporation | Osteogene Vorrichtungen |
FR2636063B1 (fr) * | 1988-09-05 | 1993-04-30 | Centre Nat Rech Scient | Composes phenylpyrroliques utiles en tant que medicaments, leur preparation et leur application |
US5106626A (en) | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
CA2017466A1 (en) | 1989-06-02 | 1990-12-02 | Michael C. Kiefer | Bone calcification factor |
CA2020729A1 (en) | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
CA2064878A1 (en) | 1989-08-21 | 1991-02-22 | Hanne Bentz | Bone-specific protein |
DE69027961T2 (de) | 1989-09-06 | 1997-01-09 | Takeda Chemical Industries Ltd | Protein, DNA und ihre Verwendung |
ES2118723T3 (es) | 1989-10-17 | 1998-10-01 | Stryker Corp | Dispositivos osteogenicos. |
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ES2120964T3 (es) | 1990-10-18 | 1998-11-16 | Stryker Corp | Peptidos osteogenicos. |
AU8941791A (en) | 1990-10-18 | 1992-05-20 | Creative Biomolecules, Inc. | Osteogenic protein |
DK0592562T3 (da) * | 1991-06-25 | 1999-08-30 | Genetics Inst | BMP-9-præparater |
DE69233559T2 (de) | 1991-08-30 | 2006-08-31 | Curis, Inc., Cambridge | Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten |
JP3693338B2 (ja) | 1991-08-30 | 2005-09-07 | キュリス インコーポレイテッド | 組織形成因子誘導による炎症反応の調節 |
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US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
-
1994
- 1994-06-06 US US08/254,353 patent/US6287816B1/en not_active Expired - Fee Related
-
1995
- 1995-06-05 DE DE69528058T patent/DE69528058T2/de not_active Expired - Fee Related
- 1995-06-05 AT AT95923706T patent/ATE223486T1/de not_active IP Right Cessation
- 1995-06-05 EP EP01129313A patent/EP1230930A3/de not_active Withdrawn
- 1995-06-05 JP JP50125096A patent/JP3706133B2/ja not_active Expired - Fee Related
- 1995-06-05 KR KR1019960707067A patent/KR100255417B1/ko not_active IP Right Cessation
- 1995-06-05 WO PCT/US1995/007084 patent/WO1995033830A1/en active IP Right Grant
- 1995-06-05 EP EP95923706A patent/EP0764208B1/de not_active Expired - Lifetime
- 1995-06-05 AU AU28170/95A patent/AU709869B2/en not_active Ceased
-
1996
- 1996-12-04 US US08/750,222 patent/US6034061A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6034061A (en) | 2000-03-07 |
US6287816B1 (en) | 2001-09-11 |
EP1230930A3 (de) | 2002-11-27 |
EP0764208A1 (de) | 1997-03-26 |
WO1995033830A1 (en) | 1995-12-14 |
EP1230930A2 (de) | 2002-08-14 |
DE69528058D1 (de) | 2002-10-10 |
AU2817095A (en) | 1996-01-04 |
AU709869B2 (en) | 1999-09-09 |
JPH10503927A (ja) | 1998-04-14 |
KR100255417B1 (ko) | 2000-05-01 |
ATE223486T1 (de) | 2002-09-15 |
JP3706133B2 (ja) | 2005-10-12 |
EP0764208B1 (de) | 2002-09-04 |
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