DE69523605D1 - Verfahren zur herstellung vom aktieven protein dimerischen - Google Patents

Verfahren zur herstellung vom aktieven protein dimerischen

Info

Publication number: DE69523605D1
Authority: DE; Germany
Prior art keywords: production; dimeric protein; active dimeric; protein; beta
Prior art date: 1994-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69523605T

Other languages

English (en)

Other versions

DE69523605T2 (de

Inventor

Nico Cerletti

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-25

Filing date

1995-07-12

Publication date

2001-12-06

1995-07-12 Application filed by Novartis AG filed Critical Novartis AG

2001-12-06 Application granted granted Critical

2001-12-06 Publication of DE69523605D1 publication Critical patent/DE69523605D1/de

2002-07-11 Publication of DE69523605T2 publication Critical patent/DE69523605T2/de

2015-07-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DE69523605T 1994-07-25 1995-07-12 Verfahren zur herstellung vom aktieven protein dimerischen Expired - Lifetime DE69523605T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94810438		1994-07-25
PCT/EP1995/002718 WO1996003432A1 (en)	1994-07-25	1995-07-12	Novel process for the production of biologically active dimeric protein

Publications (2)

Publication Number	Publication Date
DE69523605D1 true DE69523605D1 (de)	2001-12-06
DE69523605T2 DE69523605T2 (de)	2002-07-11

Family

ID=8218292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69523605T Expired - Lifetime DE69523605T2 (de)	1994-07-25	1995-07-12	Verfahren zur herstellung vom aktieven protein dimerischen

Country Status (19)

Country	Link
US (1)	US6057430A (de)
EP (1)	EP0775159B1 (de)
JP (2)	JP3923516B2 (de)
KR (1)	KR100432839B1 (de)
AT (1)	ATE207933T1 (de)
AU (1)	AU690311B2 (de)
CA (1)	CA2194582C (de)
DE (1)	DE69523605T2 (de)
DK (1)	DK0775159T3 (de)
ES (1)	ES2166401T3 (de)
FI (1)	FI118083B (de)
HU (1)	HU222830B1 (de)
IL (1)	IL114701A (de)
NO (1)	NO316926B1 (de)
NZ (1)	NZ290373A (de)
PT (1)	PT775159E (de)
TW (1)	TW440566B (de)
WO (1)	WO1996003432A1 (de)
ZA (1)	ZA956138B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW517059B (en) *	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
EP0943690B1 (de) *	1995-12-21	2006-11-29	Ajinomoto Co., Inc.	Verfahren zur rückfaltung von menschlichem activin a
DE19906096A1 (de)	1999-02-13	2000-08-17	Walter Sebald	Protein mit einem Heparin-bindenden Epitop
US20030120042A1 (en) *	2000-03-30	2003-06-26	Takao Yamada	Process for producing recombinant protein
EP1292330A1 (de) *	2000-03-31	2003-03-19	Vaccine Chip Technology APS	Immunostimulierende eigenschaften eines tgf-beta-fragmentes
US7572474B2 (en) *	2005-06-01	2009-08-11	Mead Johnson Nutrition Company	Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) *	2008-10-24	2011-12-13	Mead Johnson Nutrition Company	Nutritional composition with improved digestibility
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0604966D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
GB0604964D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Protein folding
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
US8986769B2 (en)	2008-10-24	2015-03-24	Mead Johnson Nutrition Company	Methods for preserving endogenous TGF-β
WO2018122794A1 (en)	2016-12-30	2018-07-05	Biogend Therapeutics Co., Ltd.	Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof
WO2020061067A2 (en) *	2018-09-17	2020-03-26	Board Of Regents, The University Of Texas System Texas System	Compositions and methods for treating bone injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4731440A (en) *	1985-02-22	1988-03-15	Monsanto Company	Method of somatotropin solubilization using dimethylsulfone and naturation
JPH0759598B2 (ja) *	1986-02-14	1995-06-28	藤沢薬品工業株式会社	ヒトインスリン様成長因子▲ｉ▼の製造法
AU626524B2 (en) *	1987-05-29	1992-08-06	Bristol-Myers Squibb Company	Cloning and expression of simian transforming growth factor- beta 1
US5061786A (en) *	1989-05-25	1991-10-29	Genentech, Inc.	Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5144006A (en) *	1991-06-13	1992-09-01	The Rockefeller University	Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) *	1991-11-11	1993-05-13	Ciba-Geigy Ag	Novel hybrid transforming growth factors

1995
- 1995-07-11 TW TW084107188A patent/TW440566B/zh not_active IP Right Cessation
- 1995-07-12 PT PT95926857T patent/PT775159E/pt unknown
- 1995-07-12 WO PCT/EP1995/002718 patent/WO1996003432A1/en active IP Right Grant
- 1995-07-12 EP EP95926857A patent/EP0775159B1/de not_active Expired - Lifetime
- 1995-07-12 DE DE69523605T patent/DE69523605T2/de not_active Expired - Lifetime
- 1995-07-12 HU HU9700210A patent/HU222830B1/hu not_active IP Right Cessation
- 1995-07-12 ES ES95926857T patent/ES2166401T3/es not_active Expired - Lifetime
- 1995-07-12 DK DK95926857T patent/DK0775159T3/da active
- 1995-07-12 AT AT95926857T patent/ATE207933T1/de not_active IP Right Cessation
- 1995-07-12 JP JP50540096A patent/JP3923516B2/ja not_active Expired - Fee Related
- 1995-07-12 NZ NZ290373A patent/NZ290373A/en not_active IP Right Cessation
- 1995-07-12 KR KR1019970700476A patent/KR100432839B1/ko not_active IP Right Cessation
- 1995-07-12 CA CA002194582A patent/CA2194582C/en not_active Expired - Fee Related
- 1995-07-12 AU AU31095/95A patent/AU690311B2/en not_active Ceased
- 1995-07-24 IL IL11470195A patent/IL114701A/xx not_active IP Right Cessation
- 1995-07-24 ZA ZA956138A patent/ZA956138B/xx unknown
1997
- 1997-01-20 FI FI970229A patent/FI118083B/fi active IP Right Grant
- 1997-01-24 NO NO19970325A patent/NO316926B1/no not_active IP Right Cessation
1998
- 1998-07-28 US US09/123,233 patent/US6057430A/en not_active Expired - Fee Related
2006
- 2006-11-09 JP JP2006304295A patent/JP2007031453A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DK0775159T3 (da)	2002-02-11
NZ290373A (en)	1998-04-27
ES2166401T3 (es)	2002-04-16
DE69523605T2 (de)	2002-07-11
HUT76668A (en)	1997-10-28
EP0775159A1 (de)	1997-05-28
ATE207933T1 (de)	2001-11-15
CA2194582C (en)	2008-09-02
IL114701A0 (en)	1995-11-27
JP2007031453A (ja)	2007-02-08
IL114701A (en)	2005-11-20
HU222830B1 (hu)	2003-11-28
FI970229A0 (fi)	1997-01-20
NO970325D0 (no)	1997-01-24
WO1996003432A1 (en)	1996-02-08
JPH11505506A (ja)	1999-05-21
NO970325L (no)	1997-03-06
AU3109595A (en)	1996-02-22
CA2194582A1 (en)	1996-02-08
JP3923516B2 (ja)	2007-06-06
ZA956138B (en)	1996-03-07
TW440566B (en)	2001-06-16
FI970229A (fi)	1997-01-20
NO316926B1 (no)	2004-06-28
AU690311B2 (en)	1998-04-23
US6057430A (en)	2000-05-02
FI118083B (fi)	2007-06-29
KR100432839B1 (ko)	2004-08-30
PT775159E (pt)	2002-04-29
EP0775159B1 (de)	2001-10-31

Legal Events

Date

Code

Title

Description

2002-11-28

8364

No opposition during term of opposition

2010-05-20

8328

Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

2012-01-31

R082

Change of representative

Ref document number: 775159

Country of ref document: EP

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE

Publication	Publication Date	Title
DE69523605D1 (de)	2001-12-06	Verfahren zur herstellung vom aktieven protein dimerischen
FI970258A (fi)	1997-01-22	Uusi menetelmä biologisesti aktiivisen proteiinin valmistamiseksi
ATE234124T1 (de)	2003-03-15	Verfahren zur herstellung von wirkstoffhaltigen knochenzementen
ATE178616T1 (de)	1999-04-15	Verfahren zur herstellung von biologisch aktivem protein (z.b. tgf)
DE69500091D1 (de)	1997-01-09	4-Phenylamino-Pyrimidin-Derivate, Verfahren zur Herstellung und diese enthaltende Schädlingsbekämpfungsmittel für Landwirtschaft und Gartenbau
DE69525444D1 (de)	2002-03-21	Verfahren zur herstellung von biologisch aktiven siliziumverbindungen in konzentrierter form
DE69329923T2 (de)	2001-09-27	Molkenprotein und molkenproteinhydrolysate, und verfahren zur herstellung
ATE375090T1 (de)	2007-10-15	Bioaktive peptide, ihre verwendung und verfahren zu ihre herstellung
ATE211391T1 (de)	2002-01-15	Verwendung von hmg proteinen zur herstellung von arzneimitteln mit zytotoxischer wirkung
DE237398T1 (de)	1988-06-09	Verfahren zur herstellung biologisch aktiver polypeptide, so erhaltene polypeptide und diese enthaltende zusammensetzungen.
DE3867918D1 (de)	1992-03-05	Wachstumspromotor fuer bifidobacterium-arten, prozess zu dessen herstellung und verfahren fuer dessen anwendung.
ATE25708T1 (de)	1987-03-15	Biologisch aktive konjugate, ihre herstellung und ihre anwendung.
ATE299851T1 (de)	2005-08-15	Verfahren zur herstellung von zwischenprodukten
DE60031315D1 (de)	2006-11-23	Verfahren zur Herstellung von Derivaten von i(1,5-Diaryl)pyrazol-3-ylöpropansäure
MX9700656A (es)	1998-01-31	Proceso novedoso para la produccion de proteina dimerica biologicamente activa.
MX9700657A (es)	1998-01-31	Nuevo proceso para la produccion de proteina biologicamente activa.
ATE163424T1 (de)	1998-03-15	Neue 17-(3-imino-2-alkyl-propenyl)-5beta-14beta- androstanderivate, zur behandlung von kardiovaskulären erkrankungen, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon
DE60038371D1 (de)	2008-04-30	Verfahren zur herstellung von s,s-2-hydroxypropylendiamin-n,n'-di-bernsteinsäure
DE69019543D1 (de)	1995-06-29	Verfahren zur Herstellung biologisch aktiver Polysaccharid-RON-Substanz.
DE59103718D1 (de)	1995-01-12	Verfahren zur herstellung von l-lysin produzierenden mikroorganismen.