DE69520331D1 - Massenspektrometrie von Lösungen und Vorrichtung dafür - Google Patents
Massenspektrometrie von Lösungen und Vorrichtung dafürInfo
- Publication number
- DE69520331D1 DE69520331D1 DE69520331T DE69520331T DE69520331D1 DE 69520331 D1 DE69520331 D1 DE 69520331D1 DE 69520331 T DE69520331 T DE 69520331T DE 69520331 T DE69520331 T DE 69520331T DE 69520331 D1 DE69520331 D1 DE 69520331D1
- Authority
- DE
- Germany
- Prior art keywords
- solutions
- mass spectrometry
- device therefor
- therefor
- spectrometry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
- G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/168—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission field ionisation, e.g. corona discharge
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29258994A JP3274302B2 (ja) | 1994-11-28 | 1994-11-28 | 質量分析計 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69520331D1 true DE69520331D1 (de) | 2001-04-19 |
DE69520331T2 DE69520331T2 (de) | 2001-10-31 |
Family
ID=17783737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69520331T Expired - Lifetime DE69520331T2 (de) | 1994-11-28 | 1995-11-16 | Massenspektrometrie von Lösungen und Vorrichtung dafür |
Country Status (4)
Country | Link |
---|---|
US (3) | US6121608A (de) |
EP (1) | EP0715337B1 (de) |
JP (1) | JP3274302B2 (de) |
DE (1) | DE69520331T2 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3415682B2 (ja) * | 1994-08-10 | 2003-06-09 | 株式会社日立製作所 | キャピラリー電気泳動・質量分析計 |
JP3274302B2 (ja) * | 1994-11-28 | 2002-04-15 | 株式会社日立製作所 | 質量分析計 |
US6326616B1 (en) * | 1997-10-15 | 2001-12-04 | Analytica Of Branford, Inc. | Curved introduction for mass spectrometry |
US6177669B1 (en) | 1998-09-28 | 2001-01-23 | Varian, Inc. | Vortex gas flow interface for electrospray mass spectrometry |
WO2000019193A1 (en) * | 1998-09-28 | 2000-04-06 | Varian Inc | Split flow electrospray device for mass spectrometry |
JP3982094B2 (ja) * | 1999-02-10 | 2007-09-26 | 株式会社日立製作所 | マルチキャピラリイオン化質量分析装置 |
US6326615B1 (en) * | 1999-08-30 | 2001-12-04 | Syagen Technology | Rapid response mass spectrometer system |
US6635149B1 (en) * | 2000-10-26 | 2003-10-21 | Norman Campbell | Water purification system |
US6690006B2 (en) * | 2001-05-24 | 2004-02-10 | New Objective, Inc. | Method and apparatus for multiple electrospray sample introduction |
JP4178110B2 (ja) * | 2001-11-07 | 2008-11-12 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
US6818888B2 (en) | 2002-04-04 | 2004-11-16 | Varian, Inc. | Vortex flow atmospheric pressure chemical ionization source for mass spectrometry |
AUPS177202A0 (en) * | 2002-04-16 | 2002-05-23 | Diakyne Pty Ltd | Multi-element screening of trace elements |
US7651926B2 (en) * | 2002-05-24 | 2010-01-26 | Massachusetts Institute Of Technology | Rapid patterning of nanostructures |
US8093144B2 (en) * | 2002-05-24 | 2012-01-10 | Massachusetts Institute Of Technology | Patterning of nanostructures |
DE10236344B4 (de) * | 2002-08-08 | 2007-03-29 | Bruker Daltonik Gmbh | Ionisieren an Atmosphärendruck für massenspektrometrische Analysen |
US6646257B1 (en) * | 2002-09-18 | 2003-11-11 | Agilent Technologies, Inc. | Multimode ionization source |
US7078681B2 (en) * | 2002-09-18 | 2006-07-18 | Agilent Technologies, Inc. | Multimode ionization source |
EP1550145B1 (de) * | 2002-10-10 | 2018-01-03 | Universita' Degli Studi Di Milano | Ionenquelle für massenspektrometrische analysen. |
US7173240B2 (en) * | 2004-11-05 | 2007-02-06 | Agilent Technologies, Inc. | Electrospray devices for mass spectrometry |
JP3787549B2 (ja) | 2002-10-25 | 2006-06-21 | 株式会社日立ハイテクノロジーズ | 質量分析装置及び質量分析方法 |
CA2976507C (en) * | 2003-06-09 | 2020-05-12 | Perkinelmer Health Sciences Canada, Inc. | Mass spectrometer interface |
US7015466B2 (en) * | 2003-07-24 | 2006-03-21 | Purdue Research Foundation | Electrosonic spray ionization method and device for the atmospheric ionization of molecules |
CA2567465C (en) * | 2004-05-21 | 2011-08-09 | Craig M. Whitehouse | Charged droplet sprayers |
JP4773150B2 (ja) * | 2004-07-12 | 2011-09-14 | 住友化学株式会社 | Esi用カチオン化剤及びそれを用いるsec/esims測定方法 |
JP5008568B2 (ja) | 2004-10-07 | 2012-08-22 | ウオーターズ・テクノロジーズ・コーポレイシヨン | Hplcキャピラリーカラム装置 |
US7034291B1 (en) * | 2004-10-22 | 2006-04-25 | Agilent Technologies, Inc. | Multimode ionization mode separator |
GB0501940D0 (en) * | 2005-01-29 | 2005-03-09 | Smiths Group Plc | Analytical apparatus |
USRE44887E1 (en) | 2005-05-19 | 2014-05-13 | Perkinelmer Health Sciences, Inc. | Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry |
US7872225B2 (en) * | 2006-08-25 | 2011-01-18 | Perkinelmer Health Sciences, Inc. | Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry |
EP1855306B1 (de) * | 2006-05-11 | 2019-11-13 | ISB - Ion Source & Biotechnologies S.R.L. | Ionisationsquelle und Verfahren für Massenspektrometrie |
US7935921B2 (en) * | 2006-05-26 | 2011-05-03 | Laboratory Corporation Of America Holdings | Methods and systems for the quantitative analysis of biomarkers |
JP4752676B2 (ja) * | 2006-08-24 | 2011-08-17 | 株式会社島津製作所 | 質量分析装置 |
JP2010524178A (ja) * | 2007-04-06 | 2010-07-15 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 質量分析の機器、装置および方法 |
US9091695B2 (en) * | 2007-06-01 | 2015-07-28 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
DE102007052500A1 (de) * | 2007-11-02 | 2009-06-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Verfahren und Vorrichtung für den Nachweis von mindestens einer Zielsubstanz |
CA2749875A1 (en) * | 2009-01-16 | 2010-07-22 | Canam Bioresearch Inc. | Methods of electrospray chemical synthesis and device for use therein |
US8716655B2 (en) * | 2009-07-02 | 2014-05-06 | Tricorntech Corporation | Integrated ion separation spectrometer |
EP2483910B1 (de) | 2009-09-29 | 2014-09-10 | The Trustees Of The Stevens Institute Of Technology | Ionisierung eines analyts mittels ladungsaustausch für probenanalyse unter umgebungsbedingungen |
US9150610B2 (en) * | 2009-11-16 | 2015-10-06 | Biomotif Ab | Method and apparatus to perform hydrogen-deuterium exchange |
US8704194B2 (en) | 2010-04-12 | 2014-04-22 | Canon Kabushiki Kaisha | Information acquiring apparatus and information acquiring method for acquiring mass-related information |
US9305759B2 (en) * | 2012-01-26 | 2016-04-05 | University Of The Sciences In Philadelphia | Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers |
US9275844B2 (en) * | 2012-05-16 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for nanoflow liquid jet and serial femtosecond x-ray protein crystallography |
EP2927930B8 (de) * | 2012-11-29 | 2019-08-21 | Hitachi High-Technologies Corporation | Hybride ionenquelle, massenspektrometer und ionenmobilitätsvorrichtung |
JP6091620B2 (ja) * | 2013-08-02 | 2017-03-08 | 株式会社島津製作所 | イオン化装置及び質量分析装置 |
JP2013254752A (ja) * | 2013-09-25 | 2013-12-19 | Shimadzu Corp | 液体クロマトグラフ質量分析装置 |
WO2015195599A2 (en) * | 2014-06-16 | 2015-12-23 | Purdue Research Foundation | Sample analysis systems and methods of use thereof |
CN105304451B (zh) * | 2015-10-23 | 2017-06-16 | 浙江好创生物技术有限公司 | 一种应用于质谱仪的电喷雾离子源及质谱分析方法 |
US11099161B2 (en) * | 2016-11-29 | 2021-08-24 | Shimadzu Corporation | Ionizer and mass spectrometer |
CN111052302B (zh) * | 2017-08-17 | 2023-10-13 | Dh科技发展私人贸易有限公司 | 具有不对称喷雾的apci离子源 |
US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
US11709155B2 (en) * | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
CN109860015B (zh) * | 2019-02-28 | 2021-07-06 | 苏州大学 | 一种复合电离源装置 |
CN109887825B (zh) * | 2019-04-10 | 2024-03-05 | 哈尔滨工业大学(威海) | 一种化学反应中间体质谱检测方法 |
US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
JP2023549819A (ja) * | 2021-07-20 | 2023-11-29 | エルジー・ケム・リミテッド | 液体クロマトグラフィー、イオン化装置、及び質量分析器の間のインターフェースおよびそれを用いた試料分析方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209696A (en) * | 1977-09-21 | 1980-06-24 | Fite Wade L | Methods and apparatus for mass spectrometric analysis of constituents in liquids |
JPS5935347A (ja) * | 1982-08-20 | 1984-02-27 | Masahiko Tsuchiya | イオン生成装置 |
US4960992A (en) * | 1983-08-30 | 1990-10-02 | Research Corporation Technologies | Method and means for vaporizing liquids by means of heating a sample capillary tube for detection or analysis |
JPS6079656A (ja) * | 1983-10-07 | 1985-05-07 | Hitachi Ltd | 大気圧イオン化質量分析計 |
GB8404683D0 (en) * | 1984-02-22 | 1984-03-28 | Vg Instr Group | Mass spectrometers |
JPS612246A (ja) | 1985-06-05 | 1986-01-08 | Hitachi Ltd | 電子管のステム構体 |
JP2834136B2 (ja) * | 1988-04-27 | 1998-12-09 | 株式会社日立製作所 | 質量分析計 |
US4902891A (en) * | 1988-06-03 | 1990-02-20 | Vestec Corporation | Thermospray methods and apparatus for interfacing chromatography and mass spectrometry |
JP2607698B2 (ja) * | 1989-09-29 | 1997-05-07 | 株式会社日立製作所 | 大気圧イオン化質量分析計 |
US4960991A (en) * | 1989-10-17 | 1990-10-02 | Hewlett-Packard Company | Multimode ionization source |
JP2633974B2 (ja) * | 1990-04-18 | 1997-07-23 | 株式会社日立製作所 | 試料のイオン化および質量分析のための装置 |
US5015845A (en) * | 1990-06-01 | 1991-05-14 | Vestec Corporation | Electrospray method for mass spectrometry |
US5170053A (en) | 1990-08-30 | 1992-12-08 | Finnigan Corporation | Electrospray ion source and interface apparatus and method |
JP3691522B2 (ja) | 1992-05-26 | 2005-09-07 | 株式会社日立製作所 | 液体クロマトグラフ質量分析計 |
JP3238488B2 (ja) | 1992-09-22 | 2001-12-17 | 株式会社日立製作所 | 質量分析計 |
JP3087548B2 (ja) * | 1993-12-09 | 2000-09-11 | 株式会社日立製作所 | 液体クロマトグラフ結合型質量分析装置 |
CA2656956C (en) * | 1994-02-28 | 2011-10-11 | Analytica Of Branford, Inc. | Multipole ion guide for mass spectrometry |
CA2184982C (en) * | 1994-03-08 | 2004-01-20 | Craig Whitehouse | Electrospray and atmospheric pressure chemical ionization sources |
IT1270203B (it) * | 1994-06-09 | 1997-04-29 | Fisons Instr Spa | Procedimento e dispositivo per l'introduzione di liquidi in spettrometri di massa mediante nebulizzazione elettrostatica |
US5495108A (en) * | 1994-07-11 | 1996-02-27 | Hewlett-Packard Company | Orthogonal ion sampling for electrospray LC/MS |
US5750988A (en) * | 1994-07-11 | 1998-05-12 | Hewlett-Packard Company | Orthogonal ion sampling for APCI mass spectrometry |
JP3415682B2 (ja) * | 1994-08-10 | 2003-06-09 | 株式会社日立製作所 | キャピラリー電気泳動・質量分析計 |
JP3274302B2 (ja) * | 1994-11-28 | 2002-04-15 | 株式会社日立製作所 | 質量分析計 |
JP3047808B2 (ja) | 1996-03-28 | 2000-06-05 | 日本電気株式会社 | フリップフロップ回路 |
US5726447A (en) * | 1996-07-12 | 1998-03-10 | Hewlett-Packard Company | Ionization chamber and mass spectrometer having a corona needle which is externally removable from a closed ionization chamber |
US5736741A (en) * | 1996-07-30 | 1998-04-07 | Hewlett Packard Company | Ionization chamber and mass spectrometry system containing an easily removable and replaceable capillary |
US5730741A (en) | 1997-02-07 | 1998-03-24 | Eclipse Surgical Technologies, Inc. | Guided spiral catheter |
-
1994
- 1994-11-28 JP JP29258994A patent/JP3274302B2/ja not_active Expired - Fee Related
-
1995
- 1995-11-16 EP EP95118069A patent/EP0715337B1/de not_active Expired - Lifetime
- 1995-11-16 DE DE69520331T patent/DE69520331T2/de not_active Expired - Lifetime
-
1997
- 1997-11-06 US US08/968,898 patent/US6121608A/en not_active Expired - Lifetime
-
2000
- 2000-01-27 US US09/492,352 patent/US6252225B1/en not_active Expired - Lifetime
-
2001
- 2001-05-18 US US09/859,508 patent/US6437327B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0715337A1 (de) | 1996-06-05 |
US20010022344A1 (en) | 2001-09-20 |
JP3274302B2 (ja) | 2002-04-15 |
US6252225B1 (en) | 2001-06-26 |
DE69520331T2 (de) | 2001-10-31 |
EP0715337B1 (de) | 2001-03-14 |
US6437327B2 (en) | 2002-08-20 |
JPH08145950A (ja) | 1996-06-07 |
US6121608A (en) | 2000-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |