DE69427708T2 - Stabilisierte arzneizusammensetzung enthaltend 10-hydroxy-7-ethylcamptothecin als lakton-verbindung - Google Patents

Stabilisierte arzneizusammensetzung enthaltend 10-hydroxy-7-ethylcamptothecin als lakton-verbindung

Info

Publication number
DE69427708T2
DE69427708T2 DE69427708T DE69427708T DE69427708T2 DE 69427708 T2 DE69427708 T2 DE 69427708T2 DE 69427708 T DE69427708 T DE 69427708T DE 69427708 T DE69427708 T DE 69427708T DE 69427708 T2 DE69427708 T2 DE 69427708T2
Authority
DE
Germany
Prior art keywords
hecpt
cpt
hydroxy
lakton
ethylcamptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69427708T
Other languages
English (en)
Other versions
DE69427708D1 (de
Inventor
Kochat Haridas
Herman Hausheer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioNumerik Pharmaceuticals Inc
Original Assignee
BioNumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNumerik Pharmaceuticals Inc filed Critical BioNumerik Pharmaceuticals Inc
Publication of DE69427708D1 publication Critical patent/DE69427708D1/de
Application granted granted Critical
Publication of DE69427708T2 publication Critical patent/DE69427708T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69427708T 1993-12-22 1994-12-19 Stabilisierte arzneizusammensetzung enthaltend 10-hydroxy-7-ethylcamptothecin als lakton-verbindung Expired - Lifetime DE69427708T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/172,620 US5447936A (en) 1993-12-22 1993-12-22 Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
PCT/EP1994/004210 WO1995017187A1 (en) 1993-12-22 1994-12-19 Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin

Publications (2)

Publication Number Publication Date
DE69427708D1 DE69427708D1 (de) 2001-08-16
DE69427708T2 true DE69427708T2 (de) 2001-10-25

Family

ID=22628472

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427708T Expired - Lifetime DE69427708T2 (de) 1993-12-22 1994-12-19 Stabilisierte arzneizusammensetzung enthaltend 10-hydroxy-7-ethylcamptothecin als lakton-verbindung

Country Status (8)

Country Link
US (3) US5447936A (de)
EP (1) EP0735876B1 (de)
JP (1) JP4177890B2 (de)
AT (1) ATE202932T1 (de)
CA (1) CA2176604C (de)
DE (1) DE69427708T2 (de)
ES (1) ES2160693T3 (de)
WO (1) WO1995017187A1 (de)

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Also Published As

Publication number Publication date
EP0735876B1 (de) 2001-07-11
US5674874A (en) 1997-10-07
WO1995017187A1 (en) 1995-06-29
CA2176604A1 (en) 1995-06-29
DE69427708D1 (de) 2001-08-16
CA2176604C (en) 2006-12-05
ES2160693T3 (es) 2001-11-16
JPH09507056A (ja) 1997-07-15
ATE202932T1 (de) 2001-07-15
US5674873A (en) 1997-10-07
EP0735876A1 (de) 1996-10-09
JP4177890B2 (ja) 2008-11-05
US5447936A (en) 1995-09-05

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