DE69426457D1 - Herstellung von medizinischen vorrichtungen mittels einem "solid free form fabrication" verfahren - Google Patents

Herstellung von medizinischen vorrichtungen mittels einem "solid free form fabrication" verfahren

Info

Publication number
DE69426457D1
DE69426457D1 DE69426457T DE69426457T DE69426457D1 DE 69426457 D1 DE69426457 D1 DE 69426457D1 DE 69426457 T DE69426457 T DE 69426457T DE 69426457 T DE69426457 T DE 69426457T DE 69426457 D1 DE69426457 D1 DE 69426457D1
Authority
DE
Germany
Prior art keywords
medical devices
solid free
production
free form
form fabrication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69426457T
Other languages
English (en)
Other versions
DE69426457T2 (de
Inventor
G Cima
J Cima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/200,636 external-priority patent/US5518680A/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE69426457D1 publication Critical patent/DE69426457D1/de
Application granted granted Critical
Publication of DE69426457T2 publication Critical patent/DE69426457T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/022Artificial gland structures using bioreactors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/10Hair or skin implants
    • A61F2/105Skin implants, e.g. artificial skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808Endothelial cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10Processes of additive manufacturing
    • B29C64/165Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00Processes of additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00Materials specially adapted for additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00Materials specially adapted for additive manufacturing
    • B33Y70/10Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0086Special surfaces of prostheses, e.g. for improving ingrowth for preferentially controlling or promoting the growth of specific types of cells or tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/009Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30011Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30032Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in absorbability or resorbability, i.e. in absorption or resorption time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30062(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/3028Three-dimensional shapes polyhedral different from parallelepipedal and pyramidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3093Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30932Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for retarding or preventing ingrowth of bone tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2/30942Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30962Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using stereolithography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A61F2250/0031Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00359Bone or bony tissue
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037Other properties
    • B29K2995/0063Density
    • B29K2995/0064Non-uniform density
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901Method of manufacturing prosthetic device
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249953Composite having voids in a component [e.g., porous, cellular, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249953Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249954With chemically effective material or specified gas other than air, N, or carbon dioxide in void-containing component
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249953Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249961With gradual property change within a component
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249953Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249978Voids specified as micro
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249953Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249986Void-containing component contains also a solid fiber or solid particle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249994Composite having a component wherein a constituent is liquid or is contained within preformed walls [e.g., impregnant-filled, previously void containing component, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/249921Web or sheet containing structurally defined element or component
    • Y10T428/249994Composite having a component wherein a constituent is liquid or is contained within preformed walls [e.g., impregnant-filled, previously void containing component, etc.]
    • Y10T428/249999Differentially filled foam, filled plural layers, or filled layer with coat of filling material
DE69426457T 1993-10-18 1994-10-18 Herstellung von medizinischen vorrichtungen mittels einem "solid free form fabrication" verfahren Expired - Lifetime DE69426457T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/138,345 US5490962A (en) 1993-10-18 1993-10-18 Preparation of medical devices by solid free-form fabrication methods
US08/200,636 US5518680A (en) 1993-10-18 1994-02-23 Tissue regeneration matrices by solid free form fabrication techniques
PCT/US1994/011893 WO1995011007A1 (en) 1993-10-18 1994-10-18 Preparation of medical devices by solid free-form fabrication methods

Publications (2)

Publication Number Publication Date
DE69426457D1 true DE69426457D1 (de) 2001-01-25
DE69426457T2 DE69426457T2 (de) 2001-05-23

Family

ID=22481617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426457T Expired - Lifetime DE69426457T2 (de) 1993-10-18 1994-10-18 Herstellung von medizinischen vorrichtungen mittels einem "solid free form fabrication" verfahren

Country Status (11)

Country Link
US (3) US5490962A (de)
EP (1) EP0724428B1 (de)
JP (1) JP2930420B2 (de)
AT (1) ATE198146T1 (de)
CA (1) CA2173318C (de)
DE (1) DE69426457T2 (de)
DK (1) DK0724428T3 (de)
ES (1) ES2154302T3 (de)
GR (1) GR3035455T3 (de)
PT (1) PT724428E (de)
WO (1) WO1995011007A1 (de)

Families Citing this family (492)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5740051A (en) * 1991-01-25 1998-04-14 Sanders Prototypes, Inc. 3-D model making
WO1993024112A1 (en) * 1992-05-29 1993-12-09 Vivorx, Incorporated Microencapsulation of cells
EP0579503B1 (de) * 1992-07-17 1997-11-05 Ethicon Inc. Strahlenhärtbare Urethan-Acrylatprepolymere und vernetzte Polymere
US6280771B1 (en) 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
US6176874B1 (en) * 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US8795242B2 (en) * 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US7963997B2 (en) * 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US5590454A (en) * 1994-12-21 1997-01-07 Richardson; Kendrick E. Method and apparatus for producing parts by layered subtractive machine tool techniques
US5653925A (en) * 1995-09-26 1997-08-05 Stratasys, Inc. Method for controlled porosity three-dimensional modeling
US5817206A (en) * 1996-02-07 1998-10-06 Dtm Corporation Selective laser sintering of polymer powder of controlled particle size distribution
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US7332537B2 (en) * 1996-09-04 2008-02-19 Z Corporation Three dimensional printing material system and method
US5902441A (en) 1996-09-04 1999-05-11 Z Corporation Method of three dimensional printing
US7037382B2 (en) * 1996-12-20 2006-05-02 Z Corporation Three-dimensional printer
US6007318A (en) * 1996-12-20 1999-12-28 Z Corporation Method and apparatus for prototyping a three-dimensional object
ATE421318T1 (de) 1997-02-20 2009-02-15 Massachusetts Inst Technology Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben
US6261493B1 (en) 1997-03-20 2001-07-17 Therics, Inc. Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods
US6341952B2 (en) 1997-03-20 2002-01-29 Therics, Inc. Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods
US6213168B1 (en) 1997-03-31 2001-04-10 Therics, Inc. Apparatus and method for dispensing of powders
US20030008396A1 (en) * 1999-03-17 2003-01-09 Ku David N. Poly(vinyl alcohol) hydrogel
US7147666B1 (en) * 1997-11-26 2006-12-12 Bernard Francis Grisoni Monolithic implants with openings
US20030036746A1 (en) * 2001-08-16 2003-02-20 Avi Penner Devices for intrabody delivery of molecules and systems and methods utilizing same
US20070142901A1 (en) * 1998-02-17 2007-06-21 Steinke Thomas A Expandable stent with sliding and locking radial elements
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US7658727B1 (en) * 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
US6086942A (en) 1998-05-27 2000-07-11 International Brachytherapy S.A. Fluid-jet deposition of radioactive material for brachytherapy devices
US5960609A (en) * 1998-06-12 1999-10-05 Microdose Technologies, Inc. Metering and packaging method and device for pharmaceuticals and drugs
US20050023710A1 (en) * 1998-07-10 2005-02-03 Dmitri Brodkin Solid free-form fabrication methods for the production of dental restorations
US6821462B2 (en) * 1998-07-10 2004-11-23 Jeneric/Pentron, Inc. Mass production of shells and models for dental restorations produced by solid free-form fabrication methods
US6808659B2 (en) * 1998-07-10 2004-10-26 Jeneric/Pentron Incorporated Solid free-form fabrication methods for the production of dental restorations
US6322728B1 (en) * 1998-07-10 2001-11-27 Jeneric/Pentron, Inc. Mass production of dental restorations by solid free-form fabrication methods
NZ510400A (en) * 1998-09-10 2003-03-28 Sumitomo Pharma Sustained release preparation of lipophilic drugs in which the excessive initial drug release is suppressed and a sustained release is effected
JP2002527144A (ja) * 1998-10-12 2002-08-27 セリックス, インコーポレイテッド 組織再生のための複合体およびその製造方法
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6471520B1 (en) * 1998-11-13 2002-10-29 Milwaukee School Of Engineering Model of complex structure and method of making the same
US6547994B1 (en) * 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6228437B1 (en) 1998-12-24 2001-05-08 United Technologies Corporation Method for modifying the properties of a freeform fabricated part
US6147135A (en) 1998-12-31 2000-11-14 Ethicon, Inc. Fabrication of biocompatible polymeric composites
EP1154691A4 (de) * 1999-01-05 2004-07-07 Massachusetts Eye & Ear Infirm Gezielte transsklerale gesteuerte wirkstoffabgabe an die retina und choroidae
US6923979B2 (en) 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
US6368346B1 (en) 1999-06-03 2002-04-09 American Medical Systems, Inc. Bioresorbable stent
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6527762B1 (en) 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
IT1311576B1 (it) * 1999-10-25 2002-03-13 Ghimas Spa Dispositivo medico invasivo, in particolare per la rigenerazionetissutale guidata.
JP4624626B2 (ja) * 1999-11-05 2011-02-02 ズィー コーポレイション 材料システム及び3次元印刷法
US6793497B2 (en) 1999-11-12 2004-09-21 Milwaukee School Of Engineering Molecular models
EP1229901B1 (de) * 1999-11-17 2009-03-18 Boston Scientific Limited Miniaturisierte vorrichtungen zur abgabe von molekülen in einer trägerflüssigkeit
ATE323470T1 (de) * 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
WO2001049220A1 (en) * 1999-12-30 2001-07-12 Osteotech, Inc. Intervertebral implants
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
ATE499988T1 (de) * 2000-03-02 2011-03-15 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
US7300619B2 (en) * 2000-03-13 2007-11-27 Objet Geometries Ltd. Compositions and methods for use in three dimensional model printing
US20030207959A1 (en) * 2000-03-13 2003-11-06 Eduardo Napadensky Compositions and methods for use in three dimensional model printing
US8481241B2 (en) 2000-03-13 2013-07-09 Stratasys Ltd. Compositions and methods for use in three dimensional model printing
US6772026B2 (en) * 2000-04-05 2004-08-03 Therics, Inc. System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
AU2001249935A1 (en) * 2000-04-05 2001-10-23 Therics, Inc. System and method for rapidly customizing a design and remotely manufacturing biomedical devices using a computer system
US20010050031A1 (en) * 2000-04-14 2001-12-13 Z Corporation Compositions for three-dimensional printing of solid objects
DE10018987A1 (de) * 2000-04-17 2001-10-31 Envision Technologies Gmbh Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten
WO2001091902A2 (en) 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
WO2002003966A2 (en) * 2000-07-10 2002-01-17 Therics, Inc. Method and materials for controlling migration of binder liquid in a powder
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US6432752B1 (en) * 2000-08-17 2002-08-13 Micron Technology, Inc. Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages
DE50014868D1 (de) 2000-09-25 2008-01-31 Voxeljet Technology Gmbh Verfahren zum herstellen eines bauteils in ablagerungstechnik
DE10047615A1 (de) * 2000-09-26 2002-04-25 Generis Gmbh Wechselbehälter
DE10047614C2 (de) * 2000-09-26 2003-03-27 Generis Gmbh Vorrichtung zum schichtweisen Aufbau von Modellen
CN1119231C (zh) * 2000-09-29 2003-08-27 清华大学 无加热液化过程的挤压、喷射成形工艺方法
DE10049043A1 (de) * 2000-10-04 2002-05-02 Generis Gmbh Verfahren zum Entpacken von in ungebundenem Partikelmaterial eingebetteten Formkörpern
EP1339312B1 (de) * 2000-10-10 2006-01-04 Microchips, Inc. Mikrochip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US7024248B2 (en) * 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
US20030120274A1 (en) * 2000-10-20 2003-06-26 Morris John W. Implant retaining device
US6641776B1 (en) 2000-11-15 2003-11-04 Scimed Life Systems, Inc. Method for preparing radiopaque surgical implement
US7323193B2 (en) * 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US7597715B2 (en) 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
US8123814B2 (en) 2001-02-23 2012-02-28 Biomet Manufacturing Corp. Method and appartus for acetabular reconstruction
FI110481B (fi) * 2001-03-16 2003-02-14 Vivoxid Oy Bioaktiivisten lasien ja niiden komposiittien sintraus
WO2002074353A1 (en) * 2001-03-16 2002-09-26 Vivoxid Oy Sintering of bioactive glass with localised electromagnetic and/or acoustic energy
FI20010523A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Soolien, geelien ja niiden seosten käsittely
DE10114290B4 (de) * 2001-03-23 2004-08-12 Ivoclar Vivadent Ag Desktop-Verfahren zur Herstellung von Dentalprodukten unter Verwendung des 3D-Plottings
US6660208B2 (en) 2001-03-30 2003-12-09 3D Systems, Inc. Detoxification of solid freeform fabrication materials
DE10117875C1 (de) * 2001-04-10 2003-01-30 Generis Gmbh Verfahren, Vorrichtung zum Auftragen von Fluiden sowie Verwendung einer solchen Vorrichtung
WO2002083194A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
US20050177237A1 (en) * 2001-04-12 2005-08-11 Ben Shappley Spinal cage insert, filler piece and method of manufacturing
WO2002089767A1 (en) 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US20070087048A1 (en) * 2001-05-31 2007-04-19 Abrams Andrew L Oral dosage combination pharmaceutical packaging
US20030069629A1 (en) * 2001-06-01 2003-04-10 Jadhav Balkrishna S. Bioresorbable medical devices
US20020188342A1 (en) * 2001-06-01 2002-12-12 Rykhus Robert L. Short-term bioresorbable stents
US20040173146A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US20040173147A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US6962715B2 (en) * 2001-10-24 2005-11-08 Hewlett-Packard Development Company, L.P. Method and dosage form for dispensing a bioactive substance
ATE285756T1 (de) 2001-06-28 2005-01-15 Microchips Inc Verfahren zum hermetischen versiegeln von mikrochip-reservoir-vorrichtungen
JP2003052804A (ja) * 2001-08-09 2003-02-25 Ichiro Ono インプラントの製造方法およびインプラント
JP2003070816A (ja) * 2001-08-30 2003-03-11 Pentax Corp インプラントの設計方法およびインプラント
GB0121985D0 (en) * 2001-09-11 2001-10-31 Isis Innovation Tissue engineering scaffolds
US7163691B2 (en) * 2001-10-12 2007-01-16 Osteotech, Inc. Bone graft
US7509240B2 (en) * 2001-10-15 2009-03-24 The Regents Of The University Of Michigan Solid freeform fabrication of structurally engineered multifunctional devices
WO2003037607A1 (en) * 2001-10-29 2003-05-08 Therics, Inc. A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
ES2663873T3 (es) 2001-10-29 2018-04-17 Massachusetts Institute Of Technology Forma farmacéutica con perfil de liberación de orden cero fabricada por impresión tridimensional
US20030099708A1 (en) * 2001-10-29 2003-05-29 Therics, Inc Printing or dispensing a suspension such as three-dimensional printing of dosage forms
US20050121411A1 (en) * 2002-10-29 2005-06-09 Microfabrica Inc. Medical devices and EFAB methods and apparatus for producing them
US6855167B2 (en) * 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US20030175410A1 (en) * 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
WO2003092665A2 (en) * 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
AU2003232078A1 (en) * 2002-05-06 2003-11-17 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
DE10222167A1 (de) 2002-05-20 2003-12-04 Generis Gmbh Vorrichtung zum Zuführen von Fluiden
DE10224981B4 (de) 2002-06-05 2004-08-19 Generis Gmbh Verfahren zum schichtweisen Aufbau von Modellen
EP1534191A4 (de) * 2002-08-20 2010-11-03 Exactech Inc Zusammensetzung zum tragen und abgeben von das knochenwachstum induzierendem material und verfahren zur herstellung und applikation der zusammensetzung
WO2004021923A2 (en) * 2002-09-04 2004-03-18 Reva Medical, Inc. A slide and lock stent and method of manufacture from a single piece shape
US7235195B2 (en) * 2002-09-06 2007-06-26 Novartis Ag Method for making opthalmic devices
US7087109B2 (en) * 2002-09-25 2006-08-08 Z Corporation Three dimensional printing material system and method
AU2003275326A1 (en) * 2002-09-30 2004-04-23 Massachussetts Eye And Ear Infirmary In vitro culture of tissue structures
US20040152800A1 (en) * 2002-10-09 2004-08-05 Shalaby Shalaby W. Photo-crosslinkable, crystalline, polyaxial, absorbable polyester for rapid prototyping
US20040086674A1 (en) * 2002-11-01 2004-05-06 Holman Thomas J. Laser sintering process and devices made therefrom
US6796770B2 (en) * 2002-11-06 2004-09-28 Spx Corporation Impeller and method using solid free form fabrication
AU2003261497B2 (en) * 2002-11-08 2009-02-26 Howmedica Osteonics Corp. Laser-produced porous surface
US20060147332A1 (en) * 2004-12-30 2006-07-06 Howmedica Osteonics Corp. Laser-produced porous structure
JP3927487B2 (ja) * 2002-12-02 2007-06-06 株式会社大野興業 人工骨モデルの製造方法
US7589868B2 (en) * 2002-12-11 2009-09-15 Agfa Graphics Nv Method and apparatus for creating 3D-prints and a 3-D printing system
AU2003289065A1 (en) * 2002-12-21 2004-07-14 Juridical Foundation Osaka Industrial Promotion Organization Oxide nanostructure, method for producing same, and use thereof
AU2003900180A0 (en) * 2003-01-16 2003-01-30 Silverbrook Research Pty Ltd Method and apparatus (dam001)
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US6993406B1 (en) 2003-04-24 2006-01-31 Sandia Corporation Method for making a bio-compatible scaffold
US20040247671A1 (en) * 2003-04-25 2004-12-09 Prescott James H. Solid drug formulation and device for storage and controlled delivery thereof
CN100553949C (zh) * 2003-05-21 2009-10-28 Z公司 用于来自三维印刷系统的外观模具的热塑性粉末物料体系
WO2004106041A2 (en) * 2003-05-23 2004-12-09 Z Corporation Apparatus and methods for 3d printing
US7051654B2 (en) * 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
US7067169B2 (en) * 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
AU2004247143B2 (en) * 2003-06-11 2010-09-23 Warsaw Orthopedic, Inc. Osteoimplants and methods for their manufacture
US7807077B2 (en) * 2003-06-16 2010-10-05 Voxeljet Technology Gmbh Methods and systems for the manufacture of layered three-dimensional forms
DE10327272A1 (de) * 2003-06-17 2005-03-03 Generis Gmbh Verfahren zum schichtweisen Aufbau von Modellen
EP1648415A4 (de) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc Antibiotisches produkt, seine verwendung und formulierung
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
EP1648407A4 (de) * 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc Antibiotisches produkt, seine verwendung und formulierung
JP2007502296A (ja) * 2003-08-11 2007-02-08 アドバンシス ファーマスーティカル コーポレイション ロバストペレット
AU2004264356B2 (en) * 2003-08-12 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1658034A4 (de) * 2003-08-29 2011-06-22 Middlebrook Pharmaceuticals Inc Antibiotisches produkt, seine verwendung und formulierung
WO2005023524A2 (en) * 2003-08-29 2005-03-17 Z Corporation Absorbent fillers for three-dimensional printing
WO2005027877A1 (en) * 2003-09-15 2005-03-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US20050085922A1 (en) * 2003-10-17 2005-04-21 Shappley Ben R. Shaped filler for implantation into a bone void and methods of manufacture and use thereof
CA2544726C (en) * 2003-11-07 2018-06-26 University Of Connecticut Artificial tissue systems and uses thereof
CA2550983C (en) * 2003-12-24 2013-09-17 Advancis Pharmaceutical Corporation Enhanced absorption of modified release dosage forms
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
US8328876B2 (en) * 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
EP1708651A4 (de) 2004-01-27 2011-11-02 Osteotech Inc Stabilisierte knochenpropfung
WO2005077304A1 (en) * 2004-02-06 2005-08-25 Georgia Tech Research Corporation Load bearing biocompatible device
WO2005077013A2 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Surface directed cellular attachment
DE102004008168B4 (de) 2004-02-19 2015-12-10 Voxeljet Ag Verfahren und Vorrichtung zum Auftragen von Fluiden und Verwendung der Vorrichtung
EP1727497B1 (de) 2004-03-03 2010-10-06 Mentor Corporation Verfahren zur herstellung von implantaten mit texturierter oberfläche
US7329377B2 (en) * 2004-03-12 2008-02-12 Massachusetts Institute Of Technology Cyclic shrinkage of a templated 3D network material
US20050202051A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical vehicle
US20050203482A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical dispensing apparatus and method
US7261542B2 (en) * 2004-03-18 2007-08-28 Desktop Factory, Inc. Apparatus for three dimensional printing using image layers
DE602004002379T2 (de) * 2004-03-30 2007-09-20 Fin - Ceramica Faenza S.P.A. Verfahren zur Herstellung von einer biologisch aktiven Prothesenvorrichtung zur Wiederherstellung von Knochengewebe und die Prothesenvorrichtung
DE102004022961B4 (de) 2004-05-10 2008-11-20 Envisiontec Gmbh Verfahren zur Herstellung eines dreidimensionalen Objekts mit Auflösungsverbesserung mittels Pixel-Shift
JP5184080B2 (ja) 2004-05-10 2013-04-17 エンビジョンテク・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ピクセルシフトによる分解能改善を伴う3次元物体の製造プロセス
CA2564605A1 (en) * 2004-05-12 2005-12-01 Massachusetts Institute Of Technology Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like
DE102004025374A1 (de) * 2004-05-24 2006-02-09 Technische Universität Berlin Verfahren und Vorrichtung zum Herstellen eines dreidimensionalen Artikels
AU2011213897B2 (en) * 2004-06-10 2013-05-16 Synthes (Usa) Flexible bone composite
US20050278025A1 (en) * 2004-06-10 2005-12-15 Salumedica Llc Meniscus prosthesis
TWI374036B (en) * 2004-06-10 2012-10-11 Sean Kerr Flexible bone composite
CA2572292A1 (en) * 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US7763065B2 (en) * 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US7556490B2 (en) * 2004-07-30 2009-07-07 Board Of Regents, The University Of Texas System Multi-material stereolithography
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
WO2006026768A1 (en) * 2004-09-01 2006-03-09 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US20060064133A1 (en) 2004-09-17 2006-03-23 Cardiac Pacemakers, Inc. System and method for deriving relative physiologic measurements using an external computing device
US7387359B2 (en) * 2004-09-21 2008-06-17 Z Corporation Apparatus and methods for servicing 3D printers
US7389154B2 (en) * 2004-09-29 2008-06-17 Hewlett-Packard Development Company, L.P. Fabricating a three-dimensional object
CA2583911A1 (en) * 2004-10-28 2006-05-11 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
WO2006053031A2 (en) * 2004-11-12 2006-05-18 Mayo Foundation For Medical Education And Research Photocrosslinkable poly(caprolactone fumarate)
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
JP4897699B2 (ja) * 2004-11-18 2012-03-14 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ ポリカプロラクトンとポリ(プロピレンフマレート)とのブロックコポリマー
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
WO2006062518A2 (en) * 2004-12-08 2006-06-15 Interpore Spine Ltd. Continuous phase composite for musculoskeletal repair
US8535357B2 (en) 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
US8292944B2 (en) * 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
US7488316B2 (en) * 2005-01-25 2009-02-10 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US7509738B2 (en) * 2005-01-26 2009-03-31 Honeywell International, Inc. Solid-free-form fabrication of hot gas valve discs
US7718109B2 (en) * 2005-02-14 2010-05-18 Mayo Foundation For Medical Education And Research Tissue support structure
US20100168890A1 (en) * 2005-03-24 2010-07-01 Ex One Corporation Three-Dimensional Data Extraction Using Ray Casting
US7658603B2 (en) * 2005-03-31 2010-02-09 Board Of Regents, The University Of Texas System Methods and systems for integrating fluid dispensing technology with stereolithography
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8021432B2 (en) 2005-12-05 2011-09-20 Biomet Manufacturing Corp. Apparatus for use of porous implants
US8266780B2 (en) 2005-04-21 2012-09-18 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8066778B2 (en) 2005-04-21 2011-11-29 Biomet Manufacturing Corp. Porous metal cup with cobalt bearing surface
US7780897B2 (en) * 2005-04-22 2010-08-24 Board Of Regents, The University Of Texas System Hydrogel constructs using stereolithography
EP1874525B1 (de) * 2005-04-29 2011-06-01 Mayo Foundation for Medical Education and Research Hydrophile/hydrophobe polymernetze auf der basis von poly(caprolactonfumarat), poly(ethylenglycolfumarat) und copolymere davon
JP2006318835A (ja) * 2005-05-16 2006-11-24 Seiko Epson Corp 多層化膜の形成方法および多層化膜、並びに電気光学装置、電子機器
DE202005009755U1 (de) * 2005-06-21 2005-09-08 Cervitech, Inc. Halter für Zwischenwirbelprothesen
US20070016163A1 (en) * 2005-06-28 2007-01-18 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US7914574B2 (en) * 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
WO2007022348A2 (en) * 2005-08-18 2007-02-22 Massachusetts Institute Of Technology Amplification of cell polulations from embryonic stem cells
US7742815B2 (en) * 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
WO2007047556A2 (en) * 2005-10-14 2007-04-26 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
WO2007053850A2 (en) 2005-11-01 2007-05-10 Osteotech, Inc. Bone matrix compositions and methods
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US9440003B2 (en) * 2005-11-04 2016-09-13 Boston Scientific Scimed, Inc. Medical devices having particle-containing regions with diamond-like coatings
JP5523709B2 (ja) * 2005-11-14 2014-06-18 バイオメット・3アイ・エルエルシー インプラント表面上に別個のナノ粒子を堆積させる方法
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US20070124176A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US20110145009A1 (en) * 2005-11-30 2011-06-16 Jung Edward K Y Methods and systems related to transmission of nutraceutical associatd information
US20070174128A1 (en) * 2005-11-30 2007-07-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US20080004905A1 (en) * 2006-06-28 2008-01-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for analysis of nutraceutical associated components
US20080210748A1 (en) * 2005-11-30 2008-09-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware, Systems and methods for receiving pathogen related information and responding
US20080114577A1 (en) * 2005-11-30 2008-05-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems associated with nutraceutical related assays
US7827042B2 (en) * 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US20070289258A1 (en) * 2006-06-14 2007-12-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Individualized pharmaceutical selection and packaging
US8340944B2 (en) * 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US20080052114A1 (en) * 2005-11-30 2008-02-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods related to nutraceuticals
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US20070124219A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized nutraceutical selection and packaging
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US7927787B2 (en) * 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US20070136092A1 (en) * 2005-11-30 2007-06-14 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US20080033763A1 (en) * 2005-11-30 2008-02-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems related to receiving nutraceutical associated information
US20070126157A1 (en) * 2005-12-02 2007-06-07 Z Corporation Apparatus and methods for removing printed articles from a 3-D printer
US8728387B2 (en) * 2005-12-06 2014-05-20 Howmedica Osteonics Corp. Laser-produced porous surface
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
EP1803513B1 (de) 2005-12-30 2017-03-29 Howmedica Osteonics Corp. Herstellungsverfahren von Implantaten mittels Laser
US20070292822A1 (en) * 2006-02-01 2007-12-20 Micro Dental Laboratories, Inc. Method for Production of Dental Prosthetics
US7635447B2 (en) * 2006-02-17 2009-12-22 Biomet Manufacturing Corp. Method and apparatus for forming porous metal implants
EP2001656B1 (de) * 2006-04-06 2014-10-15 3D Systems Incorporated Set zur herstellung dreidimensionaler objekte durch verwendung elektromagnetischer strahlung
RU2435585C2 (ru) * 2006-04-13 2011-12-10 Актелион Фармасьютиклз Лтд Антагонисты рецептора эндотелина, предназначенные для ранней стадии идиопатического фиброза легких
DE102006019963B4 (de) 2006-04-28 2023-12-07 Envisiontec Gmbh Vorrichtung und Verfahren zur Herstellung eines dreidimensionalen Objekts durch schichtweises Verfestigen eines unter Einwirkung von elektromagnetischer Strahlung verfestigbaren Materials mittels Maskenbelichtung
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
ITMO20060159A1 (it) * 2006-05-18 2007-11-19 Marcello Marchesi "metodo per la rigenerazione guidata di tessuti ossei e/o parodontali in ambito medico chirurgico ed odontoiatrico e dispositivo cosi' ottenibile."
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
JP5243413B2 (ja) * 2006-05-26 2013-07-24 スリーディー システムズ インコーポレーテッド 3次元プリンターで材料を処理する装置と方法
US20070288021A1 (en) * 2006-06-07 2007-12-13 Howmedica Osteonics Corp. Flexible joint implant
DE102006030350A1 (de) * 2006-06-30 2008-01-03 Voxeljet Technology Gmbh Verfahren zum Aufbauen eines Schichtenkörpers
EP2044145A1 (de) * 2006-07-05 2009-04-08 Agency for Science, Technology and Research Poröse polymergegenstände
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US7955268B2 (en) * 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
DE102006038858A1 (de) * 2006-08-20 2008-02-21 Voxeljet Technology Gmbh Selbstaushärtendes Material und Verfahren zum schichtweisen Aufbau von Modellen
US8147861B2 (en) 2006-08-15 2012-04-03 Howmedica Osteonics Corp. Antimicrobial implant
JPWO2008023462A1 (ja) 2006-08-21 2010-01-07 株式会社ネクスト21 骨模型,及び骨充填剤又は骨充填剤の製造方法
US20080077440A1 (en) * 2006-09-26 2008-03-27 Remon Medical Technologies, Ltd Drug dispenser responsive to physiological parameters
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
AU2007347158B2 (en) 2006-10-17 2011-02-03 Reva Medical, Inc. N-substituted monomers and polymers
US20080111282A1 (en) * 2006-11-10 2008-05-15 Baojun Xie Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
KR101407801B1 (ko) * 2006-12-08 2014-06-20 3디 시스템즈 인코오퍼레이티드 과산화물 경화를 사용하는 3차원 인쇄 물질 시스템 및 방법
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
WO2008086033A1 (en) * 2007-01-10 2008-07-17 Z Corporation Three-dimensional printing material system with improved color, article performance, and ease of use
US7704275B2 (en) * 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
CA2677903A1 (en) * 2007-02-12 2008-08-21 Osteotech, Inc. Joint revision implant
JP4972725B2 (ja) * 2007-02-14 2012-07-11 国立大学法人京都大学 高分子材料の直接造形法および直接造形装置
WO2008103450A2 (en) * 2007-02-22 2008-08-28 Z Corporation Three dimensional printing material system and method using plasticizer-assisted sintering
US8568649B1 (en) * 2007-03-20 2013-10-29 Bowling Green State University Three-dimensional printer, ceramic article and method of manufacture
US8475946B1 (en) 2007-03-20 2013-07-02 Bowling Green State University Ceramic article and method of manufacture
AU2008262127A1 (en) * 2007-06-14 2008-12-18 Cardiac Pacemakers, Inc. Intracorporeal pressure measurement devices and methods
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
WO2008157497A2 (en) * 2007-06-15 2008-12-24 Osteotech, Inc. Method of treating tissue
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
EP2011631B1 (de) 2007-07-04 2012-04-18 Envisiontec GmbH Verfahren und Vorrichtung zum Herstellen eines dreidimensionalen Objekts
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
US10226919B2 (en) 2007-07-18 2019-03-12 Voxeljet Ag Articles and structures prepared by three-dimensional printing method
DE102007033434A1 (de) 2007-07-18 2009-01-22 Voxeljet Technology Gmbh Verfahren zum Herstellen dreidimensionaler Bauteile
WO2009014718A1 (en) * 2007-07-24 2009-01-29 Porex Corporation Porous laser sintered articles
WO2009020607A2 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
US20100279007A1 (en) * 2007-08-14 2010-11-04 The Penn State Research Foundation 3-D Printing of near net shape products
US20100206224A1 (en) * 2007-09-24 2010-08-19 Berner Fachhochschule fur Technik und informatik HTI Device for the deposition of layers
US8265949B2 (en) 2007-09-27 2012-09-11 Depuy Products, Inc. Customized patient surgical plan
JP5209725B2 (ja) 2007-09-27 2013-06-12 スリーエム イノベイティブ プロパティズ カンパニー 歯科矯正技工器具を製造するための歯科模型のデジタル形成方法
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US8357111B2 (en) 2007-09-30 2013-01-22 Depuy Products, Inc. Method and system for designing patient-specific orthopaedic surgical instruments
WO2011106430A1 (en) 2010-02-25 2011-09-01 Depuy Products, Inc Customized patient-specific bone cutting blocks
US9173662B2 (en) 2007-09-30 2015-11-03 DePuy Synthes Products, Inc. Customized patient-specific tibial cutting blocks
US9138239B2 (en) 2007-09-30 2015-09-22 DePuy Synthes Products, Inc. Customized patient-specific tibial cutting blocks
CN102652687B (zh) 2007-09-30 2015-08-19 德普伊产品公司 定制的患者专用整形外科手术器械
US8439033B2 (en) * 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
ES2661762T3 (es) 2007-10-10 2018-04-03 Wake Forest University Health Sciences Dispositivos para tratar el tejido de la médula espinal
DE102007049058A1 (de) * 2007-10-11 2009-04-16 Voxeljet Technology Gmbh Materialsystem und Verfahren zum Verändern von Eigenschaften eines Kunststoffbauteils
WO2009052492A2 (en) 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
DE102007050679A1 (de) 2007-10-21 2009-04-23 Voxeljet Technology Gmbh Verfahren und Vorrichtung zum Fördern von Partikelmaterial beim schichtweisen Aufbau von Modellen
DE102007050953A1 (de) * 2007-10-23 2009-04-30 Voxeljet Technology Gmbh Vorrichtung zum schichtweisen Aufbau von Modellen
DK2052693T4 (da) 2007-10-26 2021-03-15 Envisiontec Gmbh Proces og fri-formfabrikationssystem til at fremstille en tredimensionel genstand
US7988721B2 (en) 2007-11-30 2011-08-02 Reva Medical, Inc. Axially-radially nested expandable device
CN101951854B (zh) * 2007-12-21 2013-12-18 3M创新有限公司 制备虚拟齿列模型和由此制造牙齿保持器的方法
US8267960B2 (en) * 2008-01-09 2012-09-18 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
WO2009097218A1 (en) 2008-01-28 2009-08-06 Biomet 3I, Llc Implant surface with increased hydrophilicity
WO2009102613A2 (en) * 2008-02-11 2009-08-20 Cardiac Pacemakers, Inc. Methods of monitoring hemodynamic status for ryhthm discrimination within the heart
WO2009102640A1 (en) * 2008-02-12 2009-08-20 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
GB0809721D0 (en) * 2008-05-28 2008-07-02 Univ Bath Improvements in or relating to joints and/or implants
US9533078B2 (en) 2008-06-25 2017-01-03 Boston Scientific Scimed, Inc. Medical devices containing therapeutic agents
DK2299926T3 (da) * 2008-06-26 2020-03-02 3M Innovative Properties Co Fremgangsmåde til fremstilling af en overførselsbakke til ortodontiske anordninger
EP2313008B1 (de) 2008-07-18 2017-04-12 Wake Forest University Health Sciences Vorrichtung zur herzgewebemodulation mittels topischer anwendung von vakuum zur minimierung von zelltod und -beschädigung
EP2339973B1 (de) * 2008-08-13 2017-10-18 Smed-Ta/Td, Llc Wirkstofffreisetzungsimplantate
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US20100042213A1 (en) 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
WO2010019807A1 (en) * 2008-08-13 2010-02-18 Smed-Ta/Td, Llc Orthopaedic implant with spatially varying porosity
JP5687622B2 (ja) * 2008-08-29 2015-03-18 スメド−ティーエイ/ティーディー・エルエルシー 整形外科インプラント
WO2010030873A1 (en) * 2008-09-12 2010-03-18 Boston Scientific Scimed, Inc. Layer by layer manufacturing of a stent
WO2010030964A2 (en) * 2008-09-12 2010-03-18 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
US10188103B2 (en) * 2008-09-15 2019-01-29 The Boeing Company Antimicrobial coating fabrication method and structure
US10537915B2 (en) 2008-09-15 2020-01-21 The Boeing Company Contaminant resistant coating fabrication structure and method
US8591423B2 (en) * 2008-10-10 2013-11-26 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
AU2009303347B2 (en) 2008-10-10 2013-10-24 Reva Medical, Inc. Expandable slide and lock stent
CA2742047A1 (en) * 2008-10-24 2010-04-29 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
WO2010059291A1 (en) 2008-11-19 2010-05-27 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
DE102008058378A1 (de) 2008-11-20 2010-05-27 Voxeljet Technology Gmbh Verfahren zum schichtweisen Aufbau von Kunststoffmodellen
US10610364B2 (en) 2008-12-04 2020-04-07 Subchondral Solutions, Inc. Method for ameliorating joint conditions and diseases and preventing bone hypertrophy
WO2010093955A1 (en) 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
US20100324378A1 (en) * 2009-06-17 2010-12-23 Tran Binh C Physiologic signal monitoring using ultrasound signals from implanted devices
US20120114755A1 (en) * 2009-06-22 2012-05-10 Mayo Foundation For Medical Education And Research Methods and materials for tissue repair
US20100331979A1 (en) * 2009-06-30 2010-12-30 Mcdade Robert L Biphasic implant device transmitting mechanical stimulus
US20100331998A1 (en) * 2009-06-30 2010-12-30 Ringeisen Timothy A Electrokinetic device for tissue repair
US9744123B2 (en) * 2009-06-30 2017-08-29 Kensey Nash Corporation Biphasic implant device providing gradient
US8888828B2 (en) 2009-07-16 2014-11-18 Covidien Lp Composite fixation device
US8323429B2 (en) * 2009-07-31 2012-12-04 United States Gypsum Company Method for preparing three-dimensional plaster objects
WO2011022550A1 (en) 2009-08-19 2011-02-24 Smith & Nephew, Inc. Porous implant structures
US8349239B2 (en) 2009-09-23 2013-01-08 Stratasys, Inc. Seam concealment for three-dimensional models
US8372330B2 (en) 2009-10-19 2013-02-12 Global Filtration Systems Resin solidification substrate and assembly
CN102686250B (zh) * 2009-11-12 2014-09-17 史密夫和内修有限公司 受控随机化的多孔结构及其制造方法
MY187036A (en) * 2010-01-05 2021-08-27 Microdose Therapeutx Inc Inhalation device and method
DE102010006939A1 (de) 2010-02-04 2011-08-04 Voxeljet Technology GmbH, 86167 Vorrichtung zum Herstellen dreidimensionaler Modelle
US8673018B2 (en) 2010-02-05 2014-03-18 AMx Tek LLC Methods of using water-soluble inorganic compounds for implants
WO2011106407A1 (en) 2010-02-25 2011-09-01 Depuy Products, Inc. Method of fabricating customized patient-specific bone cutting blocks
EP2538853A4 (de) 2010-02-25 2016-07-27 Depuy Products Inc Angepasste patientenspezifische knochenschneideblöcke
IT1398443B1 (it) * 2010-02-26 2013-02-22 Lima Lto S P A Ora Limacorporate Spa Elemento protesico integrato
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
DE102010013733A1 (de) 2010-03-31 2011-10-06 Voxeljet Technology Gmbh Vorrichtung zum Herstellen dreidimensionaler Modelle
DE102010013732A1 (de) 2010-03-31 2011-10-06 Voxeljet Technology Gmbh Vorrichtung zum Herstellen dreidimensionaler Modelle
EP2558041B1 (de) 2010-04-10 2018-01-10 Reva Medical, Inc. Dehnbarer schieber und verschlussstent
DE102010014969A1 (de) 2010-04-14 2011-10-20 Voxeljet Technology Gmbh Vorrichtung zum Herstellen dreidimensionaler Modelle
DE102010015451A1 (de) 2010-04-17 2011-10-20 Voxeljet Technology Gmbh Verfahren und Vorrichtung zum Herstellen dreidimensionaler Objekte
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
WO2014190289A2 (en) 2013-05-23 2014-11-27 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525168B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US9320601B2 (en) 2011-10-20 2016-04-26 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
EP2629780A4 (de) * 2010-10-20 2014-10-01 206 Ortho Inc Implantierbares polymer für knochen- und gefässläsionen
DE102010056346A1 (de) 2010-12-29 2012-07-05 Technische Universität München Verfahren zum schichtweisen Aufbau von Modellen
DE102011007957A1 (de) 2011-01-05 2012-07-05 Voxeljet Technology Gmbh Vorrichtung und Verfahren zum Aufbauen eines Schichtenkörpers mit wenigstens einem das Baufeld begrenzenden und hinsichtlich seiner Lage einstellbaren Körper
EP2757964B1 (de) 2011-05-26 2016-05-04 Cartiva, Inc. Konisches gelenkimplantat und zugehörige instrumente
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
US8641721B2 (en) 2011-06-30 2014-02-04 DePuy Synthes Products, LLC Customized patient-specific orthopaedic pin guides
AU2012286817A1 (en) 2011-07-26 2014-02-13 The Curators Of The University Of Missouri Engineered comestible meat
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US9364896B2 (en) 2012-02-07 2016-06-14 Medical Modeling Inc. Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology
DE102012004213A1 (de) 2012-03-06 2013-09-12 Voxeljet Technology Gmbh Verfahren und Vorrichtung zum Herstellen dreidimensionaler Modelle
ES2671740T3 (es) 2012-03-20 2018-06-08 Biomet 3I, Llc Superficie de tratamiento para una superficie de implante
US9180010B2 (en) 2012-04-06 2015-11-10 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US9135374B2 (en) 2012-04-06 2015-09-15 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
DE102012010272A1 (de) 2012-05-25 2013-11-28 Voxeljet Technology Gmbh Verfahren zum Herstellen dreidimensionaler Modelle mit speziellen Bauplattformen und Antriebssystemen
DE102012012363A1 (de) 2012-06-22 2013-12-24 Voxeljet Technology Gmbh Vorrichtung zum Aufbauen eines Schichtenkörpers mit entlang des Austragbehälters bewegbarem Vorrats- oder Befüllbehälter
CN102716512A (zh) * 2012-06-29 2012-10-10 上海大学 药物分级缓释型骨修复体制备方法
US8888480B2 (en) 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
ES2873825T3 (es) 2012-09-05 2021-11-04 Aprecia Pharmaceuticals LLC Sistema de impresión tridimensional y conjunto de equipo
WO2014047477A2 (en) * 2012-09-20 2014-03-27 Sks Ocular, Llc Multilayer biodegradable microparticles for sustained release of therapeutic agents
US20140099351A1 (en) 2012-10-04 2014-04-10 Axxia Pharmaceuticals, Llc Process for making controlled release medical implant products
DE102012020000A1 (de) 2012-10-12 2014-04-17 Voxeljet Ag 3D-Mehrstufenverfahren
DE102013004940A1 (de) 2012-10-15 2014-04-17 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von dreidimensionalen Modellen mit temperiertem Druckkopf
JP6071420B2 (ja) * 2012-10-26 2017-02-01 京セラメディカル株式会社 生体用ネジ部材
CA2889559A1 (en) 2012-10-26 2014-05-01 Wake Forest University Health Sciences Novel nanofiber-based graft for heart valve replacement and methods of using the same
EP2919823B1 (de) 2012-11-14 2019-07-03 Orthopaedic Innovation Centre Inc. Durch additive fertigung hergestellte antimikrobielle artikel
DE102012022859A1 (de) 2012-11-25 2014-05-28 Voxeljet Ag Aufbau eines 3D-Druckgerätes zur Herstellung von Bauteilen
EP2931326A1 (de) * 2012-12-11 2015-10-21 Dr.h.c. Robert Mathys Stiftung Knochenersatz und verfahren zu dessen herstellung
US9630249B2 (en) 2013-01-17 2017-04-25 Ehsan Toyserkani Systems and methods for additive manufacturing of heterogeneous porous structures and structures made therefrom
DE102013003303A1 (de) 2013-02-28 2014-08-28 FluidSolids AG Verfahren zum Herstellen eines Formteils mit einer wasserlöslichen Gussform sowie Materialsystem zu deren Herstellung
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
WO2014159337A1 (en) 2013-03-14 2014-10-02 Reva Medical, Inc. Reduced - profile slide and lock stent
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
US9724203B2 (en) 2013-03-15 2017-08-08 Smed-Ta/Td, Llc Porous tissue ingrowth structure
JP6170234B2 (ja) 2013-03-15 2017-07-26 アプレシア・ファーマスーティカルズ・カンパニー レベチラセタムを含む急速に分散する剤形
ES2761407T3 (es) * 2013-03-15 2020-05-19 Aprecia Pharmaceuticals LLC Forma de dosificación rápidamente dispersable de topiramato
US9681966B2 (en) 2013-03-15 2017-06-20 Smed-Ta/Td, Llc Method of manufacturing a tubular medical implant
US20140261430A1 (en) 2013-03-15 2014-09-18 Lucy Carol Davis Facial Mask Apparatus and Method of Making
JP6463333B2 (ja) * 2013-03-15 2019-01-30 アプレシア・ファーマスーティカルズ・カンパニー オキシカルバゼピンの急速分散性の剤形
US9241881B2 (en) * 2013-03-15 2016-01-26 Stewart J. Lustgarten Dental material and method
US9408699B2 (en) 2013-03-15 2016-08-09 Smed-Ta/Td, Llc Removable augment for medical implant
US20150037385A1 (en) 2013-08-02 2015-02-05 Northwestern University Ceramic-containing bioactive inks and printing methods for tissue engineering applications
CN105579161A (zh) 2013-08-16 2016-05-11 艾克斯温有限责任公司 三维打印的金属铸造模具和其制造方法
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
EP3057729A4 (de) 2013-10-17 2017-10-18 The Exone Company Isostatische heisspressbehälter mit 3d-druck und verfahren zur herstellung davon
DE102013018182A1 (de) 2013-10-30 2015-04-30 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von dreidimensionalen Modellen mit Bindersystem
US10730232B2 (en) * 2013-11-19 2020-08-04 Guill Tool & Engineering Co, Inc. Coextruded, multilayer and multicomponent 3D printing inputs
DE102013018031A1 (de) 2013-12-02 2015-06-03 Voxeljet Ag Wechselbehälter mit verfahrbarer Seitenwand
DE102013020491A1 (de) 2013-12-11 2015-06-11 Voxeljet Ag 3D-Infiltrationsverfahren
US9649279B2 (en) 2013-12-16 2017-05-16 Massachusetts Institute Of Technology Fortified micronutrient salt formulations
JP2017507165A (ja) 2013-12-16 2017-03-16 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤
EP2886307A1 (de) 2013-12-20 2015-06-24 Voxeljet AG Vorrichtung, Spezialpapier und Verfahren zum Herstellen von Formteilen
WO2015100084A1 (en) 2013-12-23 2015-07-02 The Exone Company Method of three-dimensional printing using a multi-component build powder
ES2745763T3 (es) 2013-12-23 2020-03-03 The Exone Co Métodos y sistemas para la impresión en tres dimensiones utilizando múltiples fluidos aglutinantes
US9415546B2 (en) * 2014-01-29 2016-08-16 Xerox Corporation System and method for controlling material drop volume in three dimensional object printing
EP3102043A4 (de) 2014-02-05 2017-08-09 Modern Meadow, Inc. Getrocknete lebensmittelprodukte aus kultivierten muskelzellen
US9527244B2 (en) 2014-02-10 2016-12-27 Global Filtration Systems Apparatus and method for forming three-dimensional objects from solidifiable paste
WO2015143553A1 (en) 2014-03-25 2015-10-01 Orthopaedic Innovation Centre Inc. Antimicrobial articles produced by additive manufacturing
DE102014004692A1 (de) 2014-03-31 2015-10-15 Voxeljet Ag Verfahren und Vorrichtung für den 3D-Druck mit klimatisierter Verfahrensführung
KR101641252B1 (ko) * 2014-04-08 2016-07-29 엘지전자 주식회사 3d 프린터의 제어장치
JP6542807B2 (ja) * 2014-05-15 2019-07-10 ノースウェスタン ユニバーシティ 3次元印刷のためのインク組成物及び前記インク組成物を使用してオブジェクトを形成する方法
DE102014007584A1 (de) 2014-05-26 2015-11-26 Voxeljet Ag 3D-Umkehrdruckverfahren und Vorrichtung
US20170120329A1 (en) 2014-05-29 2017-05-04 The Exone Company Process for Making Nickel-Based Superalloy Articles by Three-Dimensional Printing
US9327537B2 (en) 2014-06-06 2016-05-03 Xerox Corporation System for adjusting operation of a printer during three-dimensional object printing using an optical sensor
US9738032B2 (en) 2014-06-06 2017-08-22 Xerox Corporation System for controlling operation of a printer during three-dimensional object printing with reference to a distance from the surface of object
US9446556B2 (en) 2014-06-06 2016-09-20 Xerox Corporation System for compensating for drop volume variation during three-dimensional printing of an object
US9675478B2 (en) 2014-06-11 2017-06-13 Abbott Cardiovascular Systems Inc. Solvent method for forming a polymer scaffolding
US9381280B2 (en) 2014-06-13 2016-07-05 Abbott Cardiovascular Systems Inc. Plasticizers for a biodegradable scaffolding and methods of forming same
US10314942B2 (en) * 2014-06-30 2019-06-11 Bacterin International, Inc. Manufacture of biomaterial implants via three-dimensional printing technology
WO2016011098A2 (en) 2014-07-17 2016-01-21 The Exone Company Methods and apparatuses for curing three-dimensional printed articles
WO2016019937A1 (de) 2014-08-02 2016-02-11 Voxeljet Ag Verfahren und gussform, insbesondere zur verwendung in kaltgussverfahren
EP3191084B2 (de) 2014-09-08 2022-08-31 University of Central Lancashire Herstellung von fester darreichungsform
WO2016085584A2 (en) 2014-10-15 2016-06-02 Northwestern University Graphene-based ink compositions for three-dimensional printing applications
US9844930B2 (en) * 2014-11-05 2017-12-19 Xerox Corporation 3D printing of digestible shells for medicaments
US9771487B2 (en) * 2014-11-10 2017-09-26 Xerox Corporation Method of three-dimensional printing
WO2016089618A1 (en) 2014-12-03 2016-06-09 The Exone Company Process for making densified carbon articles by three dimensional printing
US10449692B2 (en) 2014-12-08 2019-10-22 Tethon Corporation Three-dimensional (3D) printing
DE102015006533A1 (de) 2014-12-22 2016-06-23 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von 3D-Formteilen mit Schichtaufbautechnik
US10279078B2 (en) 2014-12-31 2019-05-07 Bacterin International, Inc. Crosslinkable 3D printed biomaterial-based implants and methods of manufacture thereof
WO2016161025A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
AU2016243660B2 (en) 2015-03-31 2020-11-12 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
AU2016248062B2 (en) 2015-04-14 2020-01-23 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
DE102015006363A1 (de) 2015-05-20 2016-12-15 Voxeljet Ag Phenolharzverfahren
AU2016272089B2 (en) 2015-06-03 2021-02-18 Triastek, Inc. Dosage forms and use thereof
WO2017007486A1 (en) * 2015-07-09 2017-01-12 Hewlett-Packard Development Company, L.P. Generating three-dimensional objects with target surface roughness
KR102570502B1 (ko) 2015-08-21 2023-08-25 아프레시아 파마슈티칼즈 엘엘씨 3차원 인쇄 시스템 및 장비 어셈블리
DE102015011503A1 (de) 2015-09-09 2017-03-09 Voxeljet Ag Verfahren zum Auftragen von Fluiden
DE102015011790A1 (de) 2015-09-16 2017-03-16 Voxeljet Ag Vorrichtung und Verfahren zum Herstellen dreidimensionaler Formteile
US11913166B2 (en) 2015-09-21 2024-02-27 Modern Meadow, Inc. Fiber reinforced tissue composites
US11298210B2 (en) 2015-10-09 2022-04-12 John H. Khouri Orthodontic assembly
CN114587492A (zh) * 2015-11-25 2022-06-07 软骨解决方案股份有限公司 可植入矫形设备
WO2017096068A1 (en) * 2015-12-01 2017-06-08 The Trustees Of Columbia University In The City Of New York Vapor pressure solid articles and methods for making and using the same
DE102015015353A1 (de) 2015-12-01 2017-06-01 Voxeljet Ag Verfahren und Vorrichtung zur Herstellung von dreidimensionalen Bauteilen mittels Überschussmengensensor
KR20180095853A (ko) 2015-12-16 2018-08-28 너바시브 인코퍼레이티드 다공성 척추 융합 임플란트
KR101837652B1 (ko) 2016-01-04 2018-03-12 (주)퓨레코 코어-쉘 구조를 갖는 3d 프린터용 기능성 필라멘트 및 그 제조방법
WO2017143357A1 (en) * 2016-01-25 2017-08-24 Sunp Biotech, Llc Low temperature module for a 3d biological printer deposition system and build platform
WO2017143356A1 (en) * 2016-01-25 2017-08-24 Sunp Biotech, Llc High temperature module for a 3d biological printer deposition system
BR112017016266A2 (pt) 2016-02-15 2018-03-27 Modern Meadow, Inc. método para produzir um material biofabricado.
JP6878417B2 (ja) * 2016-02-17 2021-05-26 トリアステック インコーポレイテッド 剤形およびそれらの使用
US11013827B2 (en) 2016-04-30 2021-05-25 Bvw Holding Ag Microstructured haptotaxic implant
WO2017190149A1 (en) * 2016-04-30 2017-11-02 Bvw Holding Ag Microstructured haptotaxic implant
JP6559912B2 (ja) 2016-05-05 2019-08-14 トリアステック インコーポレイテッド 放出制御剤形
US10765658B2 (en) 2016-06-22 2020-09-08 Mastix LLC Oral compositions delivering therapeutically effective amounts of cannabinoids
US10022231B2 (en) * 2016-07-22 2018-07-17 Cytex Therapeutics, Inc. Articular cartilage repair
GB201612853D0 (en) 2016-07-25 2016-09-07 Univ Central Lancashire Solid dosage form production
GB201620066D0 (en) 2016-11-28 2017-01-11 Ucl Business Plc Solid Pharmaceutical dosage formulations and processes
EP3614972A4 (de) * 2017-04-27 2021-01-13 Indian Institute of Technology, Delhi 3d-druckkonstruktionen zur korrektur von knochendefekten und stammzellfreisetzung
US20210205176A1 (en) * 2017-04-28 2021-07-08 Hewlett-Packard Development Company, L.P. Producing ingredient delivery devices for release control
AU2018203479B2 (en) 2017-05-18 2024-04-18 Howmedica Osteonics Corp. High fatigue strength porous structure
JP7358340B2 (ja) 2017-05-26 2023-10-10 インフィニット・マテリアル・ソリューションズ,エルエルシー 水溶性ポリマー組成物
US11628517B2 (en) * 2017-06-15 2023-04-18 Howmedica Osteonics Corp. Porous structures produced by additive layer manufacturing
ES2871104T3 (es) * 2017-10-16 2021-10-28 Arctic Biomaterials Oy Implantes bioabsorbibles ortopédicos
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
US20200337359A1 (en) * 2017-12-29 2020-10-29 Exentis Knowledge Gmbh Method for producing a nutraceutical delivery system
US20200337358A1 (en) * 2017-12-29 2020-10-29 Exentis Knowledge Gmbh Nutraceutical delivery system
US10350822B1 (en) 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof
CN116270513A (zh) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
US11051829B2 (en) 2018-06-26 2021-07-06 DePuy Synthes Products, Inc. Customized patient-specific orthopaedic surgical instrument
GB201813186D0 (en) 2018-08-13 2018-09-26 Univ Central Lancashire Solid dosage from production
EP3704202A4 (de) 2019-01-17 2020-12-16 Modern Meadow, Inc. Geschichtete kollagenmaterialien und verfahren zu ihrer herstellung
US20200367477A1 (en) * 2019-05-24 2020-11-26 Alexander SCHOFIELD Artificial coral articles and preparation methods thereof
CN113710459A (zh) * 2019-06-10 2021-11-26 惠普发展公司,有限责任合伙企业 采用孔隙促进剂的三维打印
US11724486B2 (en) 2019-07-09 2023-08-15 Kyndryl, Inc. Printing customized medication based on current user data and medical records of the user
GB201910233D0 (en) * 2019-07-17 2019-08-28 Univ Oxford Innovation Ltd Scaffold for bone ingrowth
WO2021016288A1 (en) 2019-07-25 2021-01-28 D2 Medical Llc Bone-derived thermoplastic filament and method of manufacture
US11851641B2 (en) * 2019-08-30 2023-12-26 Han Bio Usa Method for producing stem cell culture plate available for tissue engineering using 3D printing for human organoid generation
DE202019106375U1 (de) * 2019-11-15 2019-11-25 Kumovis GmbH Orthopädisches Implantat
WO2021105878A1 (en) 2019-11-26 2021-06-03 3M Innovative Properties Company A dental template for direct bonding orthodontic appliances and methods of making and using the same
US11504879B2 (en) 2020-04-17 2022-11-22 Beehive Industries, LLC Powder spreading apparatus and system
WO2021214613A1 (en) 2020-04-24 2021-10-28 3M Innovative Properties Company An indirect bonding tray for bonding orthodontic appliances and methods of making and using the same
KR20230098628A (ko) 2020-10-30 2023-07-04 트리아스텍 인코포레이티드 위장관 약학적 제형
CN113244181B (zh) * 2021-04-28 2023-05-26 浙江工业大学 一种采用大光斑加热熔融配方粉末快速制备片剂的方法
EP4159202A1 (de) 2021-09-29 2023-04-05 Biomind Labs Inc Pharmazeutische formulierung mit einer durch 3d-drucken erhaltenen psychedelischen substanz durch selektives laser-sintern (sls)
US11771528B1 (en) 2022-09-12 2023-10-03 Spectrum Spine Ip Holdings, Llc Implant with enhanced osteoinductivity
US20240075683A1 (en) 2022-09-01 2024-03-07 Illinois Tool Works Inc. Method for manufacture of custom object complementary to vehicle exterior surface defect

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4046513A (en) * 1976-06-30 1977-09-06 Miles Laboratories, Inc. Printed reagent test devices and method of making same
US4787900A (en) 1982-04-19 1988-11-29 Massachusetts Institute Of Technology Process for forming multilayer bioreplaceable blood vessel prosthesis
US4520821A (en) * 1982-04-30 1985-06-04 The Regents Of The University Of California Growing of long-term biological tissue correction structures in vivo
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
JPS6021763A (ja) * 1983-07-15 1985-02-04 ティーディーケイ株式会社 人工骨材料
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
JPH0778017B2 (ja) * 1985-12-28 1995-08-23 住友製薬株式会社 パルス的かつ持続放出性製剤
US4927632A (en) * 1986-06-26 1990-05-22 Alza Corporation Selective pulsed drug delivery system
NL8801741A (nl) * 1988-07-08 1990-02-01 Utermoehlen Nv Kunsthuid.
JP2678945B2 (ja) * 1989-04-17 1997-11-19 有限会社ナイセム 人工血管とその製造方法及び人工血管用基質
US5204055A (en) * 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5460758A (en) * 1990-12-21 1995-10-24 Eos Gmbh Electro Optical Systems Method and apparatus for production of a three-dimensional object
DE4102259A1 (de) * 1991-01-23 1992-07-30 Artos Med Produkte Verfahren zur herstellung beliebig geformter koerper
US5348788A (en) * 1991-01-30 1994-09-20 Interpore Orthopaedics, Inc. Mesh sheet with microscopic projections and holes
DK0500225T3 (da) * 1991-01-31 1996-02-05 Texas Instruments Inc System, fremgangsmåde og proces til computerstyret fremstilling af tredimensionale genstande udfra computerdata
DE4120325A1 (de) * 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
GB9206509D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
US5496372A (en) * 1992-04-17 1996-03-05 Kyocera Corporation Hard tissue prosthesis including porous thin metal sheets
US5510066A (en) * 1992-08-14 1996-04-23 Guild Associates, Inc. Method for free-formation of a free-standing, three-dimensional body
US5370692A (en) * 1992-08-14 1994-12-06 Guild Associates, Inc. Rapid, customized bone prosthesis
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods

Also Published As

Publication number Publication date
EP0724428B1 (de) 2000-12-20
ES2154302T3 (es) 2001-04-01
WO1995011007A1 (en) 1995-04-27
DK0724428T3 (da) 2001-02-05
US6530958B1 (en) 2003-03-11
JP2930420B2 (ja) 1999-08-03
EP0724428A1 (de) 1996-08-07
CA2173318C (en) 2002-01-01
ATE198146T1 (de) 2001-01-15
JPH09502999A (ja) 1997-03-25
US5490962A (en) 1996-02-13
CA2173318A1 (en) 1995-04-27
GR3035455T3 (en) 2001-05-31
DE69426457T2 (de) 2001-05-23
US5869170A (en) 1999-02-09
PT724428E (pt) 2001-04-30

Similar Documents

Publication Publication Date Title
DE69426457D1 (de) Herstellung von medizinischen vorrichtungen mittels einem "solid free form fabrication" verfahren
US20200146775A1 (en) Orthodontic planning systems
AU2017382624B2 (en) Orthodontic planning systems
US20210106404A1 (en) Three-dimensional printed dental appliances using lattices
ATE225635T1 (de) Mittels eines herstellungsverfahrens für frei gestaltete feste strukturen hergestellte matritzen für vaskularisierte geweberegeneration
Sun et al. The application of rapid prototyping in prosthodontics
US20200129670A1 (en) Controlled randomized porous structures and methods for making same
US5762125A (en) Custom bioimplantable article
US10350055B2 (en) Textured breast implant and methods of making same
ATE357191T1 (de) Verfahren zur herstellung von giessformen
ATE361716T1 (de) Verfahren zur herstellung von zahnersatz und dentalen hilfsteilen
JP2007236926A (ja) レーザによって作製されるインプラント
US20090267261A1 (en) Rapid Production of Customized Masks
Cima et al. Preparation of medical devices by solid free-form fabrication methods
JP2014500747A (ja) 義歯用の枠組みおよびその製造方法
KR101132747B1 (ko) 3차원 세라믹 다공성 인공지지체 및 그 제조방법
Aherwar et al. A review paper on rapid prototyping and rapid tooling techniques for fabrication of prosthetic socket
Weeden et al. Alternative methods for custom implant production utilizing a combination of rapid prototyping technology and conventional investment casting
Mazzoli et al. Preliminary Considerations on the Design of Multi-layered Bone Scaffold for Laser-Based Printing
AYDIN CAN HUMAN BEINGS PRODUCE EVERYTHING? THE LIMITS OF THE 3D PRINTERS
Papallo et al. Design of Additive Manufactured Devices with Tailored Properties: Tackling Biomedical Challenges
Bhargav et al. Rapid Prototyping Use in Prosthodontics
KR20220072071A (ko) 포러스 코팅층이 형성된 생체 삽입용 임플란트
EGGBEER et al. P EVANS
Bagheri Contribution to the manufacture of porous structures for prostheses by means

Legal Events

Date Code Title Description
8364 No opposition during term of opposition