DE69417242T2 - Fluoreszenz-sauerstoffkanalisation-immunteste - Google Patents

Fluoreszenz-sauerstoffkanalisation-immunteste

Info

Publication number
DE69417242T2
DE69417242T2 DE69417242T DE69417242T DE69417242T2 DE 69417242 T2 DE69417242 T2 DE 69417242T2 DE 69417242 T DE69417242 T DE 69417242T DE 69417242 T DE69417242 T DE 69417242T DE 69417242 T2 DE69417242 T2 DE 69417242T2
Authority
DE
Germany
Prior art keywords
oxygen channel
immunity tests
fluorescence oxygen
channel immunity
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69417242T
Other languages
English (en)
Other versions
DE69417242D1 (de
Inventor
Dariush Davalian
Rajendra Singh
Edwin Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of DE69417242D1 publication Critical patent/DE69417242D1/de
Application granted granted Critical
Publication of DE69417242T2 publication Critical patent/DE69417242T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
DE69417242T 1993-09-03 1994-08-29 Fluoreszenz-sauerstoffkanalisation-immunteste Expired - Lifetime DE69417242T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11736593A 1993-09-03 1993-09-03
PCT/US1994/009705 WO1995006877A1 (en) 1993-09-03 1994-08-29 Fluorescent oxygen channeling immunoassays

Publications (2)

Publication Number Publication Date
DE69417242D1 DE69417242D1 (de) 1999-04-22
DE69417242T2 true DE69417242T2 (de) 1999-07-08

Family

ID=22372509

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69417242T Expired - Lifetime DE69417242T2 (de) 1993-09-03 1994-08-29 Fluoreszenz-sauerstoffkanalisation-immunteste

Country Status (8)

Country Link
US (2) US5616719A (de)
EP (1) EP0716746B1 (de)
JP (1) JP3498960B2 (de)
AT (1) ATE177842T1 (de)
CA (1) CA2170873A1 (de)
DE (1) DE69417242T2 (de)
ES (1) ES2135597T3 (de)
WO (1) WO1995006877A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10212960A1 (de) * 2002-03-22 2003-10-23 Gnothis Holding Sa Ecublens Verwendung von Oxazin-Farbstoffen als Markierungsgruppen für die Einzelmolekülanalyse
DE10226011A1 (de) * 2002-06-12 2004-01-08 Aventis Pharma Deutschland Gmbh HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen c-reaktivem Protein und an C-reaktives Protein bindenden Komponenten

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
WO1994002486A1 (en) * 1992-07-20 1994-02-03 Syntex (U.S.A.) Inc. Novel chemiluminescent compounds and methods of use
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
IT1275571B (it) * 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
US5811253A (en) * 1995-09-01 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Use of vanadium bromoperoxidase as a signal-generating enzyme for chemiluminescent systems: test kits and analytical methods
EP0881879B1 (de) * 1996-02-19 2003-06-18 Schaffer, Moshe Photoempfindliche zusammensetzung
DE69736382T2 (de) * 1996-05-01 2007-08-09 Dade Behring Marburg Gmbh Chemilumineszente zusammensetungen und ihre verwendung zum nachweis von wasserstoffperoxid
US6432662B1 (en) * 1997-04-15 2002-08-13 Pierce Chemical Company Assay of peroxidase activity
US6670196B1 (en) 1997-05-14 2003-12-30 Biosite, Inc. Rapid evaluation of the ratio of biological molecules
DE19756773A1 (de) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Neues Verfahren und Diagnosemittel zur Hämostase-Diagnostik
DE19756782A1 (de) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Nachweis und Bestimmung festphasenassoziierter Faktoren
WO1999036574A1 (en) * 1998-01-20 1999-07-22 Mayo Foundation For Medical Education And Research Simplified mutation detection
AU2679899A (en) * 1998-02-18 1999-09-06 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
DE19811017A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Neues Verfahren zur Bestimmung von Plasmaproteinen und Faktoren der Hämostase sowie ein neues, implantierbares Meßgerät
DE19846148C2 (de) * 1998-10-01 2002-10-10 Igor Popov Verfahren zur Beurteilung der oxidativen Modifikation proteinhaltiger Stoffe mittels Messung ihrer antiradikalen Aktivität
US7759133B2 (en) * 1998-12-22 2010-07-20 Alk-Abello A/S Method of detecting and/or quantifying a specific IgE antibody in a liquid sample
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US6649351B2 (en) 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
ATE356874T1 (de) 1999-12-22 2007-04-15 Dade Behring Marburg Gmbh Lösungen von humanem procalcitonin
ATE395364T1 (de) 1999-12-22 2008-05-15 Dade Behring Marburg Gmbh Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung
EP1267935A2 (de) 2000-01-12 2003-01-02 Light Sciences Corporation Behandlung von augenerkrankungen
EP1264181B1 (de) 2000-03-06 2007-06-06 Dade Behring Marburg GmbH Mit polysacchariden beschichtete träger, deren herstellung und verwendung
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
WO2001084157A2 (en) 2000-05-04 2001-11-08 Dade Behring Marburg Gmbh Compositions for detection of multiple analytes
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
DE10064827A1 (de) 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Nachweisverfahren
US7087395B1 (en) 2001-01-16 2006-08-08 Quest Diagnostics Investments Incorporated Vitamin D assay
EP1565747B1 (de) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Verfahren and System zum Sortieren und Trennen von Teilchen
WO2002095356A2 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
WO2002094998A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
US7358052B2 (en) * 2001-05-26 2008-04-15 Monogram Biosciences, Inc. Catalytic amplification of multiplexed assay signals
RU2296333C2 (ru) 2001-07-02 2007-03-27 Арктик Диагностикс Ой Красители на основе дифторида дипиррометенбора с двухфотонным поглощением и их применение
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
AU2003222253A1 (en) * 2002-03-05 2003-09-22 Monogram Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20030232394A1 (en) * 2002-06-12 2003-12-18 Aventis Pharma Deutschland Gmbh High throughput screening method and assay system for determining the interaction between C-reactive protein and components binding to it
US20030232401A1 (en) * 2002-06-12 2003-12-18 Pugia Michael J. Bacterial test method by glycated label binding
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
CA2490654C (en) * 2002-07-25 2012-02-07 Aclara Biosciences, Inc. Detecting receptor oligomerization
AU2003249050A1 (en) * 2002-07-26 2004-02-16 Monogram Biosciences, Inc. Lipophilic electrophoretic probes
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US7381370B2 (en) 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
JP2007502417A (ja) * 2003-08-11 2007-02-08 モノグラム バイオサイエンシズ，インコーポレーテッド 分子複合体の検出および特徴づけ
WO2005085849A2 (en) * 2003-10-24 2005-09-15 U S. Genomics, Inc Biohazard identification by fluorescent immunoassay and single molecule detection
EP1680666A4 (de) * 2003-10-27 2008-03-26 Monogram Biosciences Inc Nachweisen von menschlichen antitherapeutischen antikörpern
WO2005062048A1 (de) 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogenes nachweisverfahren
DE102005026163A1 (de) 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
DE102004042124B4 (de) * 2004-08-30 2006-07-06 Dade Behring Marburg Gmbh Homogenes Verfahren zur Bestimmung eines Analyten in Gegenwart eines Überschusses von kreuzreagierenden Substanzen
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
DE102005022047A1 (de) 2005-05-09 2006-11-30 Dade Behring Marburg Gmbh Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
US20080312092A1 (en) * 2005-07-08 2008-12-18 The University Of Denver Photoinduced Signal Amplification Through Externally Sensitized Photofragmentation in Masked Photosensitizers
JP5055289B2 (ja) 2005-11-17 2012-10-24 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド アッセイにおける非特異的結合の低減
US20090247420A1 (en) * 2005-12-12 2009-10-01 Kutateladze Andrei G Method for encoding and screening combinatorial libraries
US7226752B1 (en) * 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
US20080076139A1 (en) 2006-09-21 2008-03-27 Sharat Singh Methods and compositions for detecting the activation states of multiple signal transducers in rare circulating cells
US7790401B2 (en) 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US8735167B2 (en) * 2007-08-20 2014-05-27 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
US20110112291A1 (en) * 2007-11-30 2011-05-12 Eva Hoess Stabilization of conjugates comprising a thiourea linker
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
ES2545760T3 (es) 2008-02-25 2015-09-15 Nestec S.A. Selección de fármacos para terapia del cáncer de mama utilizando matrices de anticuerpos
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
DE102008049601A1 (de) 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay
AU2010273319B2 (en) 2009-07-15 2015-01-22 Nestec S.A. Drug selection for gastric cancer therapy using antibody-based arrays
TW201113523A (en) * 2009-08-31 2011-04-16 Mbio Diagnostics Inc Integrated sample preparation and analyte detection
DK2491385T3 (en) 2009-10-20 2017-08-28 Diatech Holdings Inc PROXIMITY-MEDIED ASSAYS FOR DETECTING ONCOGEN FUSION PROTEINS
NZ601348A (en) 2010-01-12 2014-07-25 Nestec Sa Methods for predicting response of triple-negative breast cancer to therapy
EP2395354A1 (de) * 2010-06-10 2011-12-14 Siemens Healthcare Diagnostics Products GmbH Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
US8329424B2 (en) 2010-06-25 2012-12-11 Siemens Healthcare Diagnostics Reduction in false results in assay measurements
WO2012088337A1 (en) 2010-12-23 2012-06-28 Prometheus Laboratories Inc. Drug selection for malignant cancer therapy using antibody-based arrays
EP2471945A1 (de) 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung
EP2681552A2 (de) 2011-03-02 2014-01-08 Nestec S.A. Vorhersage der arzneimittelsensitivität von tumoren der lunge auf der basis von molekularen und genetische signaturen
WO2012138785A1 (en) 2011-04-04 2012-10-11 Nestec Sa Methods for predicting and improving the survival of gastric cancer patients
WO2013025532A2 (en) 2011-08-12 2013-02-21 Siemens Healthcare Diagnostics Inc. Detection of sex steroids
WO2013033623A1 (en) 2011-09-02 2013-03-07 Nestec S.A. Profiling of signal pathway proteins to determine therapeutic efficacy
EP2788752B1 (de) 2011-12-05 2018-10-03 Pierian Holdings, Inc. Therapieauswahlverfahren für patienten mit lungenkrebs
CN102735833B (zh) * 2012-07-09 2015-01-21 沃克(天津)生物科技有限公司 甲状腺过氧化物酶抗体均相发光免疫分析试剂盒及其检测方法
CN102798725B (zh) * 2012-08-13 2015-03-18 沃克(天津)生物科技有限公司 血清总IgE测定诊断试剂盒及制备和使用方法
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
WO2015003945A1 (en) 2013-07-09 2015-01-15 Nestec S.A. Microfluidic collaborative enzyme enhanced reactive ceer immunoassay
US9121859B2 (en) 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
WO2014122600A1 (en) 2013-02-05 2014-08-14 Nestec S.A. Methods of selecting combination therapy for colorectal cancer patients
EP2954068B8 (de) 2013-02-05 2018-10-31 Pierian Holdings, Inc. Wirkstoffauswahl für eine therapie gegen nicht-kleinzelligen lungenkrebs
EP2954328A1 (de) 2013-02-05 2015-12-16 Nestec S.A. Wirkstoffauswahl für kolorektalkarzinomtherapie mit profilierung von rezeptortyrosinkinase
ES2822663T3 (es) * 2013-03-15 2021-05-04 Siemens Healthcare Diagnostics Inc Inmunoensayos de canalización de oxígeno luminiscentes heterogéneos
EP2972346A4 (de) * 2013-03-15 2016-12-07 Siemens Healthcare Diagnostics Inc Heterogene lumineszente sauerstoffkanalisierungs-immunoassays und verfahren zur herstellung und verwendung davon
SG11201509367RA (en) 2013-05-21 2015-12-30 Nestec Sa Methods for predicting and improving the survival of colorectal cancer patients
JP6619339B2 (ja) 2013-08-30 2019-12-11 ソシエテ・デ・プロデュイ・ネスレ・エス・アー ポリープ再発
WO2015083085A1 (en) 2013-12-03 2015-06-11 Nestec S.A. Signaling pathways in tissues from inflammatory bowel disease patients
JP6559135B2 (ja) 2013-12-13 2019-08-14 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 非凝集検定における前処理剤
EP2919013B1 (de) 2014-03-11 2016-11-02 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Detektion von Modulatoren der GPIb-Thrombin-Interaktion
EP2955517A1 (de) 2014-06-10 2015-12-16 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Stabilisierung von Körperflüssigkeitsproben durch die Zugabe von Detergenz
WO2017068431A1 (en) 2015-10-02 2017-04-27 Tgr Biosciences Pty Ltd. Analyte detection with multiple substrates
CN106093391A (zh) * 2016-05-31 2016-11-09 南方医科大学 一种基于单线态氧通道发光量子点传感器
DK3484686T3 (da) 2016-07-18 2023-02-20 Siemens Healthcare Diagnostics Inc Prøvebeholder med uigennemsigtige og gennemskinnelige dele, samt prøveanalysatorsystem med en sådan prøvebeholder
ES2826394T3 (es) 2017-06-09 2021-05-18 Siemens Healthcare Diagnostics Products Gmbh Ensayo de activación para el diagnóstico de una trombocitopenia inducida por heparina
ES2862434T3 (es) 2017-08-02 2021-10-07 Siemens Healthcare Diagnostics Products Gmbh Prueba de unión para el diagnóstico de trombocitopenia inducida por heparina
JP2020533595A (ja) 2017-09-13 2020-11-19 プロジェニティ， インコーポレイテッド 子癇前症バイオマーカならびに関連するシステムおよび方法
EP3514541A1 (de) 2018-01-17 2019-07-24 Siemens Healthcare Diagnostics Products GmbH Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors
MX2020011688A (es) 2018-05-04 2020-12-10 Siemens Healthcare Diagnostics Inc Unidad de iluminacion con multiples fuentes de luz para generar un punto de iluminacion uniforme.
CN112400024B (zh) 2018-06-01 2024-04-09 比奥拉治疗股份有限公司 用于胃肠道微生物组检测和处理的装置和系统
WO2019231503A1 (en) * 2018-06-01 2019-12-05 University Of Oregon Compounds for thiol-triggered cos and/or h2s release and methods of making and using the same
EP4070113A4 (de) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. Beurteilung von präeklampsie unter verwendung von tests für freien und dissoziierten plazentalen wachstumsfaktor
CN112679518B (zh) * 2020-12-29 2022-11-08 华东理工大学 基于硫代色满酮衍生物的纯有机室温磷光材料及其制备方法和应用
EP4239338A1 (de) 2022-03-03 2023-09-06 Siemens Healthcare Diagnostics Products GmbH Globaltest zur feststellung des status des blutgerinnungssystems
EP4325224A1 (de) 2022-08-18 2024-02-21 Siemens Healthcare Diagnostics Products GmbH Thrombozytenaktivierungstest zur diagnose einer heparin-induzierten thrombozytopenie

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013528A (en) * 1974-03-26 1977-03-22 Xerox Corporation Process for preparation of solid phase dispersion of photoconductive materials
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4650770A (en) * 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1294285C (en) * 1983-03-13 1992-01-14 Robert T. Buckler Optical indicator chalcogen compounds and methods for their preparation and use
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4908307A (en) * 1986-12-19 1990-03-13 Karin D. Rodland Hybridization method and probe for detecting nucleic acid sequences
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4806485A (en) * 1987-02-27 1989-02-21 Cooperative Institute For Research In Environmental Sciences Univers. Of Colorado Method of improving the detection limits of UV-VIS absorbing compounds in HPLC by the use of a singlet oxygen trap
AU636110B2 (en) * 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
US5019496A (en) * 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
CA2035029C (en) * 1989-09-06 2001-12-18 Brooks Edwards Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
EP0476556A3 (en) * 1990-09-18 1992-11-19 Takeda Chemical Industries, Ltd. Method for determination of a light sensitive substance
ATE350665T1 (de) * 1991-05-22 2007-01-15 Dade Behring Marburg Gmbh Homogenes testsystem zur bestimmung eines analytes
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
ES2113547T3 (es) * 1992-07-31 1998-05-01 Behringwerke Ag Matrices quimioluminiscentes fotoactivables.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10212960A1 (de) * 2002-03-22 2003-10-23 Gnothis Holding Sa Ecublens Verwendung von Oxazin-Farbstoffen als Markierungsgruppen für die Einzelmolekülanalyse
DE10226011A1 (de) * 2002-06-12 2004-01-08 Aventis Pharma Deutschland Gmbh HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen c-reaktivem Protein und an C-reaktives Protein bindenden Komponenten

Also Published As

Publication number Publication date
JPH09502520A (ja) 1997-03-11
DE69417242D1 (de) 1999-04-22
ATE177842T1 (de) 1999-04-15
ES2135597T3 (es) 1999-11-01
WO1995006877A1 (en) 1995-03-09
US5616719A (en) 1997-04-01
JP3498960B2 (ja) 2004-02-23
US5807675A (en) 1998-09-15
EP0716746B1 (de) 1999-03-17
CA2170873A1 (en) 1995-03-09
EP0716746A1 (de) 1996-06-19

Similar Documents

Publication Publication Date Title
DE69417242T2 (de) Fluoreszenz-sauerstoffkanalisation-immunteste
NO931695D0 (no) Nye 4-arylpiperaciner og 4-arylpiperidiner
ATE195737T1 (de) Antagonisten des fibrinogenrezeptors
ES2081636T3 (es) Preparacion de piperidinas sustituidas.
ATE180470T1 (de) Nipecotinsäurederivate als antithrombische verbindungen
SE8500107D0 (sv) Neue 8alfa-acylaminoergoline
ES8707508A1 (es) Procedimiento para preparar derivados del estilbeno asimetricos conteniendo triazinilo
AU588065B2 (en) Substituted diazaoxaspirodecanes, preparation thereof and use thereof as stabilizers for polymers
GR1002598B (el) Παραγωγα επι-επιβατιδινης.
ES2104174T3 (es) Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
DE68911237D1 (de) Nichtionische Trijodbenzin-Verbindungen und diese enthaltende Kontrastmittel.
DE69524064D1 (de) Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
ES2079724T3 (es) Nuevos compuestos antibioticos y su produccion.
DE58909089D1 (de) Verwendung von Myricetin-3-0-beta-D-glucuronid als Arzneimittel.
ECSP961927A (es) Mezclas sinergeticas que contienen ciclohexenonoxim eteres
UY24326A1 (es) Nuevas piperidinas.
SU1690242A1 (ru) Антифидант

Legal Events

Date Code Title Description
8364 No opposition during term of opposition