DE69333710D1 - Genvarianten des angiotensinogens und veranlagung zum bluthochdruck - Google Patents
Genvarianten des angiotensinogens und veranlagung zum bluthochdruckInfo
- Publication number
- DE69333710D1 DE69333710D1 DE69333710T DE69333710T DE69333710D1 DE 69333710 D1 DE69333710 D1 DE 69333710D1 DE 69333710 T DE69333710 T DE 69333710T DE 69333710 T DE69333710 T DE 69333710T DE 69333710 D1 DE69333710 D1 DE 69333710D1
- Authority
- DE
- Germany
- Prior art keywords
- angiotin
- sinogen
- geni
- variants
- high pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/952,442 US5374525A (en) | 1992-09-30 | 1992-09-30 | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
PCT/US1993/009136 WO1994008048A1 (en) | 1992-09-30 | 1993-09-29 | Angiotensinogen gene variants and predisposition to hypertension |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69333710D1 true DE69333710D1 (de) | 2004-12-30 |
Family
ID=25492918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333710T Expired - Lifetime DE69333710D1 (de) | 1992-09-30 | 1993-09-29 | Genvarianten des angiotensinogens und veranlagung zum bluthochdruck |
Country Status (10)
Country | Link |
---|---|
US (5) | US5374525A (de) |
EP (1) | EP0665898B1 (de) |
JP (1) | JP3159708B2 (de) |
KR (1) | KR950704507A (de) |
AT (1) | ATE283372T1 (de) |
AU (1) | AU670990B2 (de) |
CA (1) | CA2145415A1 (de) |
DE (1) | DE69333710D1 (de) |
NZ (1) | NZ259092A (de) |
WO (1) | WO1994008048A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374525A (en) * | 1992-09-30 | 1994-12-20 | University Of Utah Research Foundation | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
US6153386A (en) * | 1992-09-30 | 2000-11-28 | University Of Utah Research Foundation | Method to determine predisposition to hypertension |
US5750345A (en) * | 1995-10-31 | 1998-05-12 | Evanston Hospital Corporation | Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders |
DE19613606C1 (de) | 1996-04-04 | 1997-04-30 | Progen Biotechnik Gmbh | Gen für Hypertonie |
US6114118A (en) * | 1996-09-20 | 2000-09-05 | Texas A&M University System | Method of identification of animals resistant or susceptible to disease such as ruminant brucellosis, tuberculosis, paratuberculosis and salmonellosis |
US6197505B1 (en) * | 1997-04-04 | 2001-03-06 | Pyrosequencing Ab | Methods for assessing cardiovascular status and compositions for use thereof |
US20020123467A1 (en) * | 1999-09-02 | 2002-09-05 | Institut Pasteur | Therapeutic composition comprising the KAL protein and use of the KAL protein for the treatment of retinal, renal, neuronal and neural injury |
US6610497B1 (en) * | 1997-12-11 | 2003-08-26 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor |
US6194556B1 (en) * | 1997-12-11 | 2001-02-27 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor |
DE69930726T2 (de) * | 1998-01-12 | 2007-01-25 | Massachusetts Institute Of Technology, Cambridge | Verfahren und vorrichtung zur mikrotestdurchführung |
US6893877B2 (en) | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
US6525185B1 (en) * | 1998-05-07 | 2003-02-25 | Affymetrix, Inc. | Polymorphisms associated with hypertension |
CA2342921A1 (en) | 1998-09-04 | 2000-03-16 | University Of Utah Research Foundation | Drug screening and diagnosis based on paracrine tubular renin-angiotensin system |
JP2002529718A (ja) * | 1998-11-10 | 2002-09-10 | ジェンセット | 検出可能な形質と結合された遺伝子を含むゲノム領域を同定するための方法、ソフトウエアおよび装置 |
EP1165235B1 (de) | 1999-03-19 | 2011-09-28 | Life Technologies Corporation | Methode zum sichten von mutierten zellen |
AU5016200A (en) * | 1999-05-21 | 2000-12-12 | Myriad Genetics, Inc. | Diabetes gene |
US6902888B1 (en) | 1999-05-21 | 2005-06-07 | Myriad Genetics, Inc. | Diabetes gene |
US20020119448A1 (en) * | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
US6177252B1 (en) * | 1999-08-27 | 2001-01-23 | University Of Utah Research Foundation | Method to determine predisposition to hypertension |
US7076437B1 (en) | 1999-10-29 | 2006-07-11 | Victor Levy | Process for consumer-directed diagnostic and health care information |
US20020151040A1 (en) | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
CA2400644C (en) * | 2000-02-18 | 2009-07-14 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
US20040248092A1 (en) * | 2000-05-26 | 2004-12-09 | Vance Jeffrey M | Methods of screening for parkinsons's disease |
WO2002002000A2 (en) * | 2000-06-30 | 2002-01-10 | Duke University | Methods of screening for alzheimer's disease |
US20050239125A1 (en) * | 2000-09-06 | 2005-10-27 | Hodge Timothy A | Methods for genotype screening |
US20030219776A1 (en) * | 2001-12-18 | 2003-11-27 | Jean-Marc Lalouel | Molecular variants, haplotypes and linkage disequilibrium within the human angiotensinogen gene |
EP1481066A2 (de) * | 2002-02-27 | 2004-12-01 | Bayer HealthCare AG | Einzelnukleotidpolymorphismen zur vorhersage negativer arzneistoffreaktionen und der medikationswirksamkeit |
US20040014109A1 (en) * | 2002-05-23 | 2004-01-22 | Pericak-Vance Margaret A. | Methods and genes associated with screening assays for age at onset and common neurodegenerative diseases |
WO2004005534A2 (en) * | 2002-07-08 | 2004-01-15 | Duke University | Screening for alzheimer's disease |
US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
EP1608952B1 (de) | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen |
US20060246437A1 (en) * | 2003-07-11 | 2006-11-02 | Pericak-Vance Margaret A | Genetic susceptibility genes for asthma and atopy and asthma-related and atopic-related phenotypes |
US20060068428A1 (en) * | 2003-11-03 | 2006-03-30 | Duke University | Identification of genetic markers associated with parkinson disease |
US20050191652A1 (en) * | 2003-11-03 | 2005-09-01 | Vance Jeffery M. | Identification of genetic forms of a gene that leads to high risk for parkinson disease |
CA2559171A1 (en) | 2004-03-12 | 2005-09-29 | Biotrove, Inc. | Nanoliter array loading |
US20060105453A1 (en) | 2004-09-09 | 2006-05-18 | Brenan Colin J | Coating process for microfluidic sample arrays |
US7790390B2 (en) * | 2004-10-27 | 2010-09-07 | Duke University | Methods for identifying an individual at increased risk of developing coronary artery disease |
US7807465B2 (en) * | 2004-10-27 | 2010-10-05 | Duke University | Methods for identifying an individual at increased risk of developing coronary artery disease |
WO2006069592A2 (en) * | 2004-12-31 | 2006-07-06 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Method for diagnosing an/or predicting preeclampsia and/or related disorders |
US20070148661A1 (en) * | 2005-07-19 | 2007-06-28 | Duke University | LSAMP Gene Associated With Cardiovascular Disease |
JP2007075015A (ja) * | 2005-09-14 | 2007-03-29 | Tokai Univ | 高血圧症の検査用マーカー遺伝子 |
WO2010104646A1 (en) * | 2009-03-09 | 2010-09-16 | Scott and White Memorial Hospital | Method of testing a patient for hypertension and related method of treatment and test kit |
JP6811094B2 (ja) | 2014-05-22 | 2021-01-13 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | アンジオテンシノーゲン(AGT)iRNA組成物およびその使用 |
CN108588211B (zh) * | 2018-05-02 | 2020-05-19 | 青岛泱深生物医药有限公司 | 一种子痫前期的生物标志物及其应用 |
TW202016304A (zh) | 2018-05-14 | 2020-05-01 | 美商阿尼拉製藥公司 | 血管收縮素原(AGT)iRNA組成物及其使用方法 |
MX2022005692A (es) | 2019-11-13 | 2022-06-08 | Alnylam Pharmaceuticals Inc | Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt). |
KR20240026203A (ko) | 2021-06-30 | 2024-02-27 | 알닐람 파마슈티칼스 인코포레이티드 | 안지오텐시노겐(agt)-관련 장애를 치료하는 방법 및 조성물 |
TW202337474A (zh) | 2021-08-04 | 2023-10-01 | 美商艾拉倫製藥股份有限公司 | 用於緘默血管收縮素原(AGT)的iRNA組成物及方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6153386A (en) * | 1992-09-30 | 2000-11-28 | University Of Utah Research Foundation | Method to determine predisposition to hypertension |
US5374525A (en) * | 1992-09-30 | 1994-12-20 | University Of Utah Research Foundation | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
-
1992
- 1992-09-30 US US07/952,442 patent/US5374525A/en not_active Expired - Lifetime
-
1993
- 1993-09-29 EP EP94903230A patent/EP0665898B1/de not_active Expired - Lifetime
- 1993-09-29 DE DE69333710T patent/DE69333710D1/de not_active Expired - Lifetime
- 1993-09-29 NZ NZ259092A patent/NZ259092A/en unknown
- 1993-09-29 AT AT94903230T patent/ATE283372T1/de not_active IP Right Cessation
- 1993-09-29 WO PCT/US1993/009136 patent/WO1994008048A1/en active IP Right Grant
- 1993-09-29 JP JP50921194A patent/JP3159708B2/ja not_active Expired - Fee Related
- 1993-09-29 CA CA002145415A patent/CA2145415A1/en not_active Abandoned
- 1993-09-29 KR KR1019950701223A patent/KR950704507A/ko not_active Application Discontinuation
- 1993-09-29 AU AU57250/94A patent/AU670990B2/en not_active Ceased
-
1994
- 1994-07-01 US US08/269,766 patent/US5589584A/en not_active Expired - Lifetime
- 1994-10-07 US US08/319,545 patent/US5763168A/en not_active Expired - Lifetime
-
1998
- 1998-06-08 US US09/092,988 patent/US5998145A/en not_active Expired - Lifetime
-
1999
- 1999-10-29 US US09/429,034 patent/US6165727A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6165727A (en) | 2000-12-26 |
US5763168A (en) | 1998-06-09 |
KR950704507A (ko) | 1995-11-20 |
NZ259092A (en) | 1996-05-28 |
EP0665898A1 (de) | 1995-08-09 |
WO1994008048A1 (en) | 1994-04-14 |
EP0665898B1 (de) | 2004-11-24 |
US5374525A (en) | 1994-12-20 |
EP0665898A4 (de) | 1998-08-05 |
JPH08505043A (ja) | 1996-06-04 |
US5998145A (en) | 1999-12-07 |
CA2145415A1 (en) | 1994-04-14 |
US5589584A (en) | 1996-12-31 |
ATE283372T1 (de) | 2004-12-15 |
JP3159708B2 (ja) | 2001-04-23 |
AU670990B2 (en) | 1996-08-08 |
AU5725094A (en) | 1994-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |