DE69330784D1 - Grosse, latente komplexe von tgf-beta2 und tgf-beta3 - Google Patents
Grosse, latente komplexe von tgf-beta2 und tgf-beta3Info
- Publication number
- DE69330784D1 DE69330784D1 DE69330784T DE69330784T DE69330784D1 DE 69330784 D1 DE69330784 D1 DE 69330784D1 DE 69330784 T DE69330784 T DE 69330784T DE 69330784 T DE69330784 T DE 69330784T DE 69330784 D1 DE69330784 D1 DE 69330784D1
- Authority
- DE
- Germany
- Prior art keywords
- tgf
- beta
- beta3
- beta2
- ltbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/826,577 US5280109A (en) | 1992-01-27 | 1992-01-27 | Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2 |
PCT/US1993/000561 WO1993015114A1 (en) | 1992-01-27 | 1993-01-19 | Large, latent complexes of tgf-beta2 and tgf-beta3 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69330784D1 true DE69330784D1 (de) | 2001-10-25 |
DE69330784T2 DE69330784T2 (de) | 2002-05-23 |
Family
ID=25246945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69330784T Expired - Fee Related DE69330784T2 (de) | 1992-01-27 | 1993-01-19 | Grosse, latente komplexe von tgf-beta2 und tgf-beta3 |
Country Status (9)
Country | Link |
---|---|
US (2) | US5280109A (de) |
EP (1) | EP0624165B1 (de) |
JP (1) | JP3390005B2 (de) |
KR (1) | KR100234497B1 (de) |
AT (1) | ATE205857T1 (de) |
AU (1) | AU660213B2 (de) |
CA (1) | CA2128784C (de) |
DE (1) | DE69330784T2 (de) |
WO (1) | WO1993015114A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229495A (en) * | 1991-06-18 | 1993-07-20 | Ludwig Institute For Cancer Research | Substantially pure receptor like TGF-β 1 binding molecules and uses thereof |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6395494B1 (en) * | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5770609A (en) * | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) * | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
ATE406909T1 (de) * | 1993-05-13 | 2008-09-15 | Poniard Pharmaceuticals Inc | Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind |
US6197789B1 (en) | 1995-06-07 | 2001-03-06 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
US5656450A (en) * | 1994-05-27 | 1997-08-12 | Board Of Regents, The University Of Texas System | Activation of latent transforming growth factor β by matrix vesicles |
US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6117911A (en) * | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4931548A (en) * | 1987-01-30 | 1990-06-05 | Techne Corporation | Heterodimer form of transforming growth factor-beta |
US5177197A (en) * | 1990-02-27 | 1993-01-05 | Ludwig Institute For Cancer Research | Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein |
WO1991019513A1 (en) * | 1990-06-20 | 1991-12-26 | Bristol-Myers Squibb Company | METHODS OF MODULATING BLOOD PRESSURE USING TGF-β AND ANTAGONISTS THEREOF |
-
1992
- 1992-01-27 US US07/826,577 patent/US5280109A/en not_active Expired - Fee Related
-
1993
- 1993-01-19 AT AT93903627T patent/ATE205857T1/de not_active IP Right Cessation
- 1993-01-19 CA CA002128784A patent/CA2128784C/en not_active Expired - Fee Related
- 1993-01-19 EP EP93903627A patent/EP0624165B1/de not_active Expired - Lifetime
- 1993-01-19 DE DE69330784T patent/DE69330784T2/de not_active Expired - Fee Related
- 1993-01-19 KR KR1019940702586A patent/KR100234497B1/ko not_active IP Right Cessation
- 1993-01-19 AU AU34817/93A patent/AU660213B2/en not_active Ceased
- 1993-01-19 WO PCT/US1993/000561 patent/WO1993015114A1/en active IP Right Grant
- 1993-01-19 JP JP51333093A patent/JP3390005B2/ja not_active Expired - Fee Related
- 1993-07-15 US US08/092,331 patent/US5346993A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2128784A1 (en) | 1993-08-05 |
AU3481793A (en) | 1993-09-01 |
WO1993015114A1 (en) | 1993-08-05 |
EP0624165B1 (de) | 2001-09-19 |
US5346993A (en) | 1994-09-13 |
EP0624165A4 (en) | 1996-01-24 |
EP0624165A1 (de) | 1994-11-17 |
AU660213B2 (en) | 1995-06-15 |
JPH07503251A (ja) | 1995-04-06 |
DE69330784T2 (de) | 2002-05-23 |
CA2128784C (en) | 2002-04-30 |
US5280109A (en) | 1994-01-18 |
KR100234497B1 (ko) | 1999-12-15 |
JP3390005B2 (ja) | 2003-03-24 |
ATE205857T1 (de) | 2001-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |