DE69309790T2 - Cyclopentanperhydrophenanthren-17-beta-(3-Furyl)-3-Derivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen - Google Patents
Cyclopentanperhydrophenanthren-17-beta-(3-Furyl)-3-Derivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-ErkrankungenInfo
- Publication number
- DE69309790T2 DE69309790T2 DE69309790T DE69309790T DE69309790T2 DE 69309790 T2 DE69309790 T2 DE 69309790T2 DE 69309790 T DE69309790 T DE 69309790T DE 69309790 T DE69309790 T DE 69309790T DE 69309790 T2 DE69309790 T2 DE 69309790T2
- Authority
- DE
- Germany
- Prior art keywords
- furyl
- beta
- derivatives
- treatment
- pharmaceutical preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0021—Oxiranes at position 14(15)
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69309790T DE69309790T2 (de) | 1992-07-01 | 1993-06-16 | Cyclopentanperhydrophenanthren-17-beta-(3-Furyl)-3-Derivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4221636A DE4221636C1 (de) | 1992-07-01 | 1992-07-01 | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate |
DE69309790T DE69309790T2 (de) | 1992-07-01 | 1993-06-16 | Cyclopentanperhydrophenanthren-17-beta-(3-Furyl)-3-Derivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69309790D1 DE69309790D1 (de) | 1997-05-22 |
DE69309790T2 true DE69309790T2 (de) | 1997-09-11 |
Family
ID=6462265
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4221636A Expired - Fee Related DE4221636C1 (de) | 1992-07-01 | 1992-07-01 | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate |
DE69309790T Expired - Fee Related DE69309790T2 (de) | 1992-07-01 | 1993-06-16 | Cyclopentanperhydrophenanthren-17-beta-(3-Furyl)-3-Derivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4221636A Expired - Fee Related DE4221636C1 (de) | 1992-07-01 | 1992-07-01 | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate |
Country Status (9)
Country | Link |
---|---|
US (2) | US5432169A (de) |
EP (1) | EP0576915B1 (de) |
JP (1) | JPH0665284A (de) |
AT (1) | ATE151774T1 (de) |
DE (2) | DE4221636C1 (de) |
DK (1) | DK0576915T3 (de) |
ES (1) | ES2099865T3 (de) |
GR (1) | GR3023310T3 (de) |
HK (1) | HK1005877A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4221636C1 (de) * | 1992-07-01 | 1994-03-31 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate |
DE4227616C2 (de) * | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
DE4232656C2 (de) * | 1992-09-29 | 1995-01-12 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen |
US5677293A (en) * | 1993-10-27 | 1997-10-14 | Merrell Pharmaceuticals Inc. | 16 unsaturated C17 heterocyclic steroids useful as steroid C17-20 lyase inhibitors |
IT1282286B1 (it) * | 1995-05-11 | 1998-03-16 | Sigma Tau Ind Farmaceuti | Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono. |
IT1282289B1 (it) * | 1995-06-23 | 1998-03-16 | Sigma Tau Ind Farmaceuti | 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare, |
JP3875125B2 (ja) * | 2001-04-11 | 2007-01-31 | シャープ株式会社 | 液晶表示装置 |
US20040064050A1 (en) * | 2002-09-20 | 2004-04-01 | Jun Liu | System and method for screening tissue |
PT1951738E (pt) * | 2005-11-25 | 2012-04-18 | Rostaquo S P A | Novas formas cristalinas de rostafuroxin |
FI3599243T3 (fi) * | 2018-07-26 | 2023-06-22 | Cvie Therapeutics Ltd | 17beeta-heterosyklyylidigitaliksen kaltaisia yhdisteitä sydämen vajaatoiminnan hoitoon |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1227015B (de) * | 1963-01-23 | 1966-10-20 | Bayer Ag | Verfahren zur Herstellung von 3beta-Hydroxy-(bzw.-Acyloxy)-steroid-20-amidylhydrazonen der Pregnanreihe |
GB1081647A (en) * | 1965-04-01 | 1967-08-31 | Shionogi & Co | Furan compounds |
US3436390A (en) * | 1966-05-24 | 1969-04-01 | American Home Prod | 4,4-dihydroxy-2-butenoic acid lactones |
DE1807585C3 (de) * | 1968-11-04 | 1974-11-07 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 14,15beta-Epoxycardenolide, Verfahren zu deren Herstellung und diese enthaltende Mittel |
DE1812946C3 (de) * | 1968-12-05 | 1978-11-02 | Hoechst Ag, 6000 Frankfurt | Herzwirksame 14beta, lSbeta Oxidobutatrienolide und Verfahren zu ihrer Herstellung |
US4259240A (en) * | 1979-09-28 | 1981-03-31 | Advance Biofactures Corporation | Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom |
GB8916636D0 (en) * | 1989-07-20 | 1989-09-06 | Erba Carlo Spa | Steroid ethers |
DE4221636C1 (de) * | 1992-07-01 | 1994-03-31 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate |
-
1992
- 1992-07-01 DE DE4221636A patent/DE4221636C1/de not_active Expired - Fee Related
-
1993
- 1993-06-16 ES ES93109612T patent/ES2099865T3/es not_active Expired - Lifetime
- 1993-06-16 DE DE69309790T patent/DE69309790T2/de not_active Expired - Fee Related
- 1993-06-16 AT AT93109612T patent/ATE151774T1/de not_active IP Right Cessation
- 1993-06-16 DK DK93109612.7T patent/DK0576915T3/da active
- 1993-06-16 EP EP93109612A patent/EP0576915B1/de not_active Expired - Lifetime
- 1993-06-25 US US08/081,111 patent/US5432169A/en not_active Expired - Fee Related
- 1993-06-30 JP JP5161249A patent/JPH0665284A/ja active Pending
-
1995
- 1995-05-09 US US08/437,801 patent/US5593982A/en not_active Expired - Fee Related
-
1997
- 1997-05-02 GR GR970400966T patent/GR3023310T3/el unknown
-
1998
- 1998-06-05 HK HK98104945A patent/HK1005877A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0576915A3 (en) | 1994-07-06 |
ES2099865T3 (es) | 1997-06-01 |
JPH0665284A (ja) | 1994-03-08 |
EP0576915B1 (de) | 1997-04-16 |
ATE151774T1 (de) | 1997-05-15 |
DE69309790D1 (de) | 1997-05-22 |
DE4221636C1 (de) | 1994-03-31 |
EP0576915A2 (de) | 1994-01-05 |
GR3023310T3 (en) | 1997-08-29 |
DK0576915T3 (da) | 1997-09-01 |
HK1005877A1 (en) | 1999-01-29 |
US5593982A (en) | 1997-01-14 |
US5432169A (en) | 1995-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |