DE69306755T2 - Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln - Google Patents

Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln

Info

Publication number
DE69306755T2
DE69306755T2 DE69306755T DE69306755T DE69306755T2 DE 69306755 T2 DE69306755 T2 DE 69306755T2 DE 69306755 T DE69306755 T DE 69306755T DE 69306755 T DE69306755 T DE 69306755T DE 69306755 T2 DE69306755 T2 DE 69306755T2
Authority
DE
Germany
Prior art keywords
milling
drug
polypeptide drugs
drugs
stabilizers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306755T
Other languages
English (en)
Other versions
DE69306755D1 (de
Inventor
Robert Platz
Anna Ip
Clyde Witham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of DE69306755D1 publication Critical patent/DE69306755D1/de
Application granted granted Critical
Publication of DE69306755T2 publication Critical patent/DE69306755T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE69306755T 1992-01-21 1993-01-20 Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln Expired - Fee Related DE69306755T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82321892A 1992-01-21 1992-01-21
PCT/US1993/000373 WO1993013752A1 (en) 1992-01-21 1993-01-20 Improved process for preparing micronized polypeptide drugs

Publications (2)

Publication Number Publication Date
DE69306755D1 DE69306755D1 (de) 1997-01-30
DE69306755T2 true DE69306755T2 (de) 1997-04-10

Family

ID=25238119

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306755T Expired - Fee Related DE69306755T2 (de) 1992-01-21 1993-01-20 Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln

Country Status (7)

Country Link
US (1) US5354562A (de)
EP (1) EP0621774B1 (de)
JP (1) JPH07503154A (de)
AT (1) ATE146359T1 (de)
CA (1) CA2127877A1 (de)
DE (1) DE69306755T2 (de)
WO (1) WO1993013752A1 (de)

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Also Published As

Publication number Publication date
CA2127877A1 (en) 1993-07-22
DE69306755D1 (de) 1997-01-30
EP0621774A1 (de) 1994-11-02
EP0621774B1 (de) 1996-12-18
US5354562A (en) 1994-10-11
WO1993013752A1 (en) 1993-07-22
JPH07503154A (ja) 1995-04-06
ATE146359T1 (de) 1997-01-15

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