DE69233022D1 - Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung - Google Patents

Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung

Info

Publication number
DE69233022D1
DE69233022D1 DE69233022T DE69233022T DE69233022D1 DE 69233022 D1 DE69233022 D1 DE 69233022D1 DE 69233022 T DE69233022 T DE 69233022T DE 69233022 T DE69233022 T DE 69233022T DE 69233022 D1 DE69233022 D1 DE 69233022D1
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DE
Germany
Prior art keywords
methods
compositions
bone morphogenetic
morphogenetic protein
recombinant bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233022T
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English (en)
Other versions
DE69233022T2 (de
Inventor
David Israel
M Wolfman
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Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of DE69233022D1 publication Critical patent/DE69233022D1/de
Publication of DE69233022T2 publication Critical patent/DE69233022T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69233022T 1991-11-04 1992-11-02 Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung Expired - Lifetime DE69233022T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78749691A 1991-11-04 1991-11-04
US787496 1991-11-04
US86469292A 1992-04-07 1992-04-07
US864692 1992-04-07
PCT/US1992/009430 WO1993009229A1 (en) 1991-11-04 1992-11-02 Recombinant bone morphogenetic protein heterodimers, compositions and methods of use

Publications (2)

Publication Number Publication Date
DE69233022D1 true DE69233022D1 (de) 2003-05-28
DE69233022T2 DE69233022T2 (de) 2004-02-12

Family

ID=27120657

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233022T Expired - Lifetime DE69233022T2 (de) 1991-11-04 1992-11-02 Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung

Country Status (9)

Country Link
US (5) US5866364A (de)
EP (1) EP0612348B1 (de)
JP (2) JP3504263B2 (de)
KR (1) KR100259827B1 (de)
AT (1) ATE238417T1 (de)
AU (1) AU674500B2 (de)
DE (1) DE69233022T2 (de)
MX (1) MX9206315A (de)
WO (1) WO1993009229A1 (de)

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