US6444798B1
(en)
*
|
1988-06-06 |
2002-09-03 |
Steven Albert Benner |
Chimeras of sulfur-linked oligonucleotide analogs and DNA and RNA
|
US5681941A
(en)
*
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US6005087A
(en)
*
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US6783931B1
(en)
|
1990-01-11 |
2004-08-31 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
US6399754B1
(en)
|
1991-12-24 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides
|
US5859221A
(en)
*
|
1990-01-11 |
1999-01-12 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
US5872232A
(en)
*
|
1990-01-11 |
1999-02-16 |
Isis Pharmaceuticals Inc. |
2'-O-modified oligonucleotides
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
US7037646B1
(en)
|
1990-01-11 |
2006-05-02 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
US6358931B1
(en)
|
1990-01-11 |
2002-03-19 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating RNA
|
US20040142899A1
(en)
*
|
1990-01-11 |
2004-07-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
US5623070A
(en)
*
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US6121433A
(en)
*
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
US5378825A
(en)
*
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
US5998603A
(en)
*
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
US5618704A
(en)
*
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
US5541307A
(en)
*
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
US5602240A
(en)
*
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
US5610289A
(en)
*
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
US5386023A
(en)
*
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
WO1992002534A2
(en)
*
|
1990-08-03 |
1992-02-20 |
Sterling Drug, Inc. |
Compounds and methods for inhibiting gene expression
|
US5789573A
(en)
*
|
1990-08-14 |
1998-08-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
|
WO1992005186A1
(en)
*
|
1990-09-20 |
1992-04-02 |
Gilead Sciences |
Modified internucleoside linkages
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
US5965722A
(en)
*
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
US5359044A
(en)
*
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
US5543507A
(en)
*
|
1992-03-05 |
1996-08-06 |
Isis Pharmaceuticals, Inc. |
Covalently cross-linked oligonucleotides
|
EP0635023B1
(de)
*
|
1992-03-05 |
2002-02-06 |
Isis Pharmaceuticals, Inc. |
Kovalent vernetzte oligonukleotide
|
US6117847A
(en)
*
|
1992-03-16 |
2000-09-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for enhanced modulation of protein kinase C expression
|
US6537973B1
(en)
|
1992-03-16 |
2003-03-25 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide inhibition of protein kinase C
|
GB9207380D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Compounds
|
US5434257A
(en)
*
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
US5817781A
(en)
|
1992-06-01 |
1998-10-06 |
Gilead Sciences, Inc. |
Modified internucleoside linkages (II)
|
CA2138770A1
(en)
*
|
1992-06-24 |
1994-01-06 |
Phillip Dan Cook |
Heteroatomic oligonucleoside linkages
|
US6784290B1
(en)
|
1992-10-05 |
2004-08-31 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide inhibition of ras
|
CA2146320C
(en)
*
|
1992-10-05 |
2004-12-14 |
Brett P. Monia |
Antisense oligonucleotide inhibition of the ras gene
|
US5872242A
(en)
*
|
1992-10-05 |
1999-02-16 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide inhibition of ras
|
US5985558A
(en)
|
1997-04-14 |
1999-11-16 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
|
US20030013670A1
(en)
*
|
1992-10-05 |
2003-01-16 |
Monia Brett P. |
Antisense oligonucleotide inhibition of ras
|
EP0691977B1
(de)
*
|
1993-03-31 |
1997-11-26 |
Sanofi |
Oligonucleotide mit amidverkettungen die phosphoesterverkettungen einsetzen
|
AU6551094A
(en)
*
|
1993-03-31 |
1994-10-24 |
Sterling Winthrop Inc. |
Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
|
GB9311682D0
(en)
*
|
1993-06-05 |
1993-07-21 |
Ciba Geigy Ag |
Chemical compounds
|
US6605708B1
(en)
|
1993-07-28 |
2003-08-12 |
Hybridon, Inc. |
Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom
|
US6653458B1
(en)
|
1993-09-03 |
2003-11-25 |
Isis Pharmaceuticals, Inc. |
Modified oligonucleotides
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
HU220423B
(hu)
*
|
1994-01-26 |
2002-01-28 |
Novartis Ag. |
Módosított oligonukleotidok
|
US5625050A
(en)
*
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
US6391636B1
(en)
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
US5981731A
(en)
*
|
1994-05-31 |
1999-11-09 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of B-raf gene expression
|
WO1996005298A1
(en)
*
|
1994-08-09 |
1996-02-22 |
Ciba-Geigy Ag |
Antitumor antisense oligonucleotides
|
GB9417746D0
(en)
*
|
1994-09-03 |
1994-10-19 |
Ciba Geigy Ag |
Chemical compounds
|
GB9417938D0
(en)
*
|
1994-09-06 |
1994-10-26 |
Ciba Geigy Ag |
Compounds
|
US5681940A
(en)
*
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
EP0714907A1
(de)
*
|
1994-11-30 |
1996-06-05 |
F. Hoffmann-La Roche Ag |
Oligonukleotide mit Amid-Hauptkette
|
US5807718A
(en)
|
1994-12-02 |
1998-09-15 |
The Scripps Research Institute |
Enzymatic DNA molecules
|
US6207826B1
(en)
|
1995-03-27 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Macrocyclic compounds having nitrogen-containing linkages
|
JPH10508036A
(ja)
|
1995-03-27 |
1998-08-04 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
窒素含有大環状化合物
|
US6420549B1
(en)
*
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
US6143749A
(en)
*
|
1995-06-07 |
2000-11-07 |
Abbott Laboratories |
Heterocyclic substituted cyclopentane compounds
|
AU701106B2
(en)
|
1995-06-07 |
1999-01-21 |
Promega Biosciences, Inc. |
Novel carbamate-based cationic lipids
|
US5665721A
(en)
*
|
1995-06-07 |
1997-09-09 |
Abbott Laboratories |
Heterocyclic substituted cyclopentane compounds
|
US5855911A
(en)
*
|
1995-08-29 |
1999-01-05 |
Board Of Regents, The University Of Texas System |
Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
US5856099A
(en)
*
|
1996-05-21 |
1999-01-05 |
Isis Pharmaceuticals, Inc. |
Antisense compositions and methods for modulating type I interleukin-1 receptor expression
|
US20040161777A1
(en)
*
|
1996-06-06 |
2004-08-19 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
WO2005121368A1
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Chimeric gapped oligomeric compositions
|
US20050042647A1
(en)
*
|
1996-06-06 |
2005-02-24 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
US20040147022A1
(en)
*
|
1996-06-06 |
2004-07-29 |
Baker Brenda F. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
US20040203024A1
(en)
*
|
1996-06-06 |
2004-10-14 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US7812149B2
(en)
*
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20050119470A1
(en)
*
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
US20050053976A1
(en)
*
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
US9096636B2
(en)
*
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
GB9612600D0
(en)
|
1996-06-13 |
1996-08-21 |
Ciba Geigy Ag |
Chemical compounds
|
AU3340797A
(en)
*
|
1996-06-28 |
1998-01-21 |
Novartis Ag |
Modified oligonucleotides
|
US7309692B1
(en)
|
1996-07-08 |
2007-12-18 |
Board Of Regents, The University Of Texas System |
Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
|
US6077954A
(en)
|
1996-08-01 |
2000-06-20 |
Isis Pharmaceuticals, Inc. |
Substituted heterocyclic compounds
|
WO1998005766A1
(fr)
*
|
1996-08-02 |
1998-02-12 |
Bio Merieux |
Procede d'amplification d'une sequence d'un acide nucleique cible
|
US6111085A
(en)
*
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
US6977244B2
(en)
*
|
1996-10-04 |
2005-12-20 |
Board Of Regents, The University Of Texas Systems |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
US5780241A
(en)
*
|
1996-11-05 |
1998-07-14 |
Isis Pharmaceuticals, Inc. |
Complex chemical libraries
|
US6077833A
(en)
*
|
1996-12-31 |
2000-06-20 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US7235653B2
(en)
|
1996-12-31 |
2007-06-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US6319906B1
(en)
|
1996-12-31 |
2001-11-20 |
Isis Pharmaceuticals |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US6576752B1
(en)
*
|
1997-02-14 |
2003-06-10 |
Isis Pharmaceuticals, Inc. |
Aminooxy functionalized oligomers
|
US6172209B1
(en)
*
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
US6639062B2
(en)
*
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
US6127533A
(en)
*
|
1997-02-14 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
2'-O-aminooxy-modified oligonucleotides
|
CA2287520C
(en)
|
1997-04-29 |
2010-12-14 |
The Scripps Research Institute |
Enzymatic dna molecules
|
WO1999001579A1
(en)
|
1997-07-01 |
1999-01-14 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
US6809193B2
(en)
|
1997-08-13 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
|
US5877309A
(en)
*
|
1997-08-13 |
1999-03-02 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides against JNK
|
US20070149472A1
(en)
*
|
1997-08-13 |
2007-06-28 |
Mckay Robert |
Antisense oligonucleotide compositions and methods for the modulation of jnk proteins
|
US6133246A
(en)
*
|
1997-08-13 |
2000-10-17 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
|
US20030165888A1
(en)
*
|
2001-07-18 |
2003-09-04 |
Brown Bob D. |
Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
|
US6518017B1
(en)
*
|
1997-10-02 |
2003-02-11 |
Oasis Biosciences Incorporated |
Combinatorial antisense library
|
US7704962B1
(en)
|
1997-10-03 |
2010-04-27 |
Board Of Regents, The University Of Texas System |
Small oligonucleotides with anti-tumor activity
|
US7285288B1
(en)
|
1997-10-03 |
2007-10-23 |
Board Of Regents, The University Of Texas System |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US5948902A
(en)
*
|
1997-11-20 |
1999-09-07 |
South Alabama Medical Science Foundation |
Antisense oligonucleotides to human serine/threonine protein phosphatase genes
|
US5968748A
(en)
*
|
1998-03-26 |
1999-10-19 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of human HER-2 expression
|
US20040186071A1
(en)
*
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
US6841539B1
(en)
|
1998-05-21 |
2005-01-11 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
EP1080103A4
(de)
*
|
1998-05-21 |
2003-07-02 |
Isis Pharmaceuticals Inc |
Zubereitungen und verfahren zur nicht-parenteralen verabreichung von oligonukleotiden
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
US6673912B1
(en)
|
1998-08-07 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
2′-O-aminoethyloxyethyl-modified oligonucleotides
|
US20040009938A1
(en)
*
|
1998-08-07 |
2004-01-15 |
Muthiah Manoharan |
Methods of enhancing renal uptake of oligonucleotides
|
US6175004B1
(en)
|
1998-09-01 |
2001-01-16 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
US6492111B1
(en)
|
1998-11-25 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
In situ binary synthesis of biologically effective molecules
|
US6087112A
(en)
*
|
1998-12-30 |
2000-07-11 |
Oligos Etc. Inc. |
Arrays with modified oligonucleotide and polynucleotide compositions
|
US20030180789A1
(en)
*
|
1998-12-30 |
2003-09-25 |
Dale Roderic M.K. |
Arrays with modified oligonucleotide and polynucleotide compositions
|
US6403779B1
(en)
|
1999-01-08 |
2002-06-11 |
Isis Pharmaceuticals, Inc. |
Regioselective synthesis of 2′-O-modified nucleosides
|
US6399765B1
(en)
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
WO2000055314A2
(en)
|
1999-03-18 |
2000-09-21 |
United Therapeutics Corporation |
Inhibitors of endothelin-1 synthesis
|
US6235891B1
(en)
|
1999-03-31 |
2001-05-22 |
South Alabama Medical Science Foundation |
Glucocorticoid receptor agonist and decreased PP5
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
EP1173614A4
(de)
*
|
1999-04-08 |
2003-10-29 |
Oasis Biosciences Inc |
Antisense oligonukleotide enthaltend universelle und/oder degenerierte basen
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US6277982B1
(en)
|
1999-08-20 |
2001-08-21 |
Isis Pharmaceuticals, Inc. |
Alkylation of alcohols, amines, thiols and their derivatives by cyclic sulfate intermediates
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
CN1274072C
(zh)
*
|
2000-08-03 |
2006-09-06 |
松下电器产业株式会社 |
无刷电机及其制造方法
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
CA2451643C
(en)
|
2001-06-21 |
2012-11-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
EP1488233A4
(de)
|
2001-10-09 |
2006-06-21 |
Genentech Inc |
Neue saure säugerproteine und diese codierende polynukleotide
|
DE10159904A1
(de)
*
|
2001-12-06 |
2003-07-03 |
Adnagen Ag |
Oligonukleotidanordnung, Verfahren zum Nukleotidnachweis sowie Vorrichtung hierfür
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
US20040043950A1
(en)
*
|
2002-01-03 |
2004-03-04 |
Board Of Regents, The University Of Texas System |
WT1 antisense oligos for the inhibition of breast cancer
|
EP1572902B1
(de)
*
|
2002-02-01 |
2014-06-11 |
Life Technologies Corporation |
HOCHWIRKSAME siRNAS ZUR REDUZIERUNG DER EXPRESSION VON ZIELGENEN
|
JP2005515780A
(ja)
|
2002-02-01 |
2005-06-02 |
セクイター インコーポレイテッド |
二本鎖オリゴヌクレオチド
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
US20030191075A1
(en)
*
|
2002-02-22 |
2003-10-09 |
Cook Phillip Dan |
Method of using modified oligonucleotides for hepatic delivery
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
AU2003257285A1
(en)
*
|
2002-07-25 |
2004-02-16 |
Micrologix Biotech Inc. |
Inhibitors of rna dependent rna polymerase and uses thereof
|
DE60310944T3
(de)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Weitere neue formen von interferierende rns moleküle
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
JP2005538186A
(ja)
*
|
2002-09-13 |
2005-12-15 |
レプリコール インコーポレーティッド |
非配列相補性の抗ウイルス性オリゴヌクレオチド
|
AU2003273336A1
(en)
*
|
2002-09-18 |
2004-04-08 |
Isis Pharmaceuticals, Inc. |
Efficient reduction of target rna's by single- and double-stranded oligomeric compounds
|
EP1549767A4
(de)
|
2002-09-26 |
2006-06-07 |
Amgen Inc |
Modulation der expression von forkhead-box o1a
|
EP1560839A4
(de)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
Chimäre oligomere verbindungen und derenverwendung in der genmodulation
|
EP1578765A4
(de)
*
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
Oligomere verbindungen,die zuckerersatzstoffe enthalten, und zusammensetzung zur verwendung in dergenmodulation
|
EP1569695B1
(de)
|
2002-11-13 |
2013-05-15 |
Genzyme Corporation |
Antisense-modulation von apolipoprotein-b-expression
|
DK2336318T3
(da)
|
2002-11-13 |
2013-07-15 |
Genzyme Corp |
Antisense-modulering af apolipoprotein b-ekspression
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
CA2515484C
(en)
|
2003-02-11 |
2011-09-20 |
Antisense Therapeutics Ltd |
Modulation of insulin like growth factor i receptor expression
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
AU2004220556B2
(en)
|
2003-03-07 |
2009-05-07 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
EP2664672A1
(de)
|
2003-04-17 |
2013-11-20 |
Alnylam Pharmaceuticals Inc. |
Modifizierte iRNA-Wirkstoffe
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
US20040219533A1
(en)
*
|
2003-04-29 |
2004-11-04 |
Jim Davis |
Biological bar code
|
US8679789B2
(en)
*
|
2003-05-01 |
2014-03-25 |
Gen-Probe Incorporated |
Oligonucleotides comprising a molecular switch
|
US7960355B2
(en)
|
2003-05-23 |
2011-06-14 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of the expression of B7 protein
|
US7897582B2
(en)
|
2003-05-23 |
2011-03-01 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
WO2004108081A2
(en)
*
|
2003-06-02 |
2004-12-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
WO2005002507A2
(en)
|
2003-06-03 |
2005-01-13 |
Isis Pharmaceuticals, Inc. |
Modulation of survivin expression
|
DK3604537T3
(da)
|
2003-06-13 |
2022-02-28 |
Alnylam Europe Ag |
Dobbeltstrenget ribonukleinsyre med forøget effektivitet i en organisme
|
WO2005044976A2
(en)
*
|
2003-06-20 |
2005-05-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds for use in gene modulation
|
WO2005017108A2
(en)
*
|
2003-06-30 |
2005-02-24 |
United Soybean Board |
Soybean selection system based on aec-resistance
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US20070123480A1
(en)
*
|
2003-09-11 |
2007-05-31 |
Replicor Inc. |
Oligonucleotides targeting prion diseases
|
EP2182063A3
(de)
|
2003-09-18 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Modulierung von EIF4E-Expression
|
AU2004274021B2
(en)
*
|
2003-09-18 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
US7125945B2
(en)
*
|
2003-09-19 |
2006-10-24 |
Varian, Inc. |
Functionalized polymer for oligonucleotide purification
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
EP1711606A2
(de)
|
2004-01-20 |
2006-10-18 |
Isis Pharmaceuticals, Inc. |
Modulation der expression des glucocorticoidrezeptors
|
US8569474B2
(en)
*
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
US7674778B2
(en)
|
2004-04-30 |
2010-03-09 |
Alnylam Pharmaceuticals |
Oligonucleotides comprising a conjugate group linked through a C5-modified pyrimidine
|
EP1758937B1
(de)
|
2004-05-24 |
2009-09-02 |
Genvault Corporation |
Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form
|
EP2471922A1
(de)
|
2004-05-28 |
2012-07-04 |
Asuragen, Inc. |
Verfahren und Zusammensetzungen mit microRNA
|
AU2005252662B2
(en)
*
|
2004-06-03 |
2011-08-18 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
US8394947B2
(en)
*
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
US7968762B2
(en)
*
|
2004-07-13 |
2011-06-28 |
Van Andel Research Institute |
Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF)
|
EP2990410A1
(de)
|
2004-08-10 |
2016-03-02 |
Alnylam Pharmaceuticals Inc. |
Chemisch modifizierte oligonukleotide
|
AP2007003921A0
(en)
|
2004-08-16 |
2007-02-28 |
Atugen Ag |
Therapeutic uses of inhibitors of rtp801
|
JP2008511678A
(ja)
|
2004-09-02 |
2008-04-17 |
イェール ユニバーシティ |
マイクロrnaによるオンコジーンの調節
|
US7884086B2
(en)
*
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006034348A2
(en)
|
2004-09-17 |
2006-03-30 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
EP2322616A1
(de)
|
2004-11-12 |
2011-05-18 |
Asuragen, Inc. |
Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind
|
WO2008073922A2
(en)
|
2006-12-08 |
2008-06-19 |
Asuragen, Inc. |
Functions and targets of let-7 micro rnas
|
ES2586410T3
(es)
|
2005-02-11 |
2016-10-14 |
Memorial Sloan-Kettering Cancer Center |
Procedimientos y composiciones de detección de un mutante de EGFR resistente a fármacos
|
EP1871913A2
(de)
*
|
2005-03-25 |
2008-01-02 |
Ambion, Inc. |
Verfahren und zusammensetzungen zur verringerung abundanter rna-transkripte
|
JP4773513B2
(ja)
|
2005-05-06 |
2011-09-14 |
ジェン−プローブ・インコーポレーテッド |
A型及びb型インフルエンザウイルスの核酸を検出するための組成物及びアッセイ
|
WO2007002528A1
(en)
*
|
2005-06-23 |
2007-01-04 |
Yale University |
Anti-aging micrornas
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
WO2007047912A2
(en)
|
2005-10-17 |
2007-04-26 |
Gen-Probe Incorporated |
Compositions and methods to detect legionella pneumophila nucleic acid
|
AU2006305886C1
(en)
*
|
2005-10-28 |
2011-03-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
US20100069461A1
(en)
|
2005-11-09 |
2010-03-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor v leiden mutant gene
|
NL2000439C2
(nl)
|
2006-01-20 |
2009-03-16 |
Quark Biotech |
Therapeutische toepassingen van inhibitoren van RTP801.
|
EP2314594B1
(de)
*
|
2006-01-27 |
2014-07-23 |
Isis Pharmaceuticals, Inc. |
6-Modifizierte bicyclische Nukleinsäureanaloga
|
WO2008054834A2
(en)
|
2006-02-03 |
2008-05-08 |
Columbia University |
Binary deoxyribozyme probes for nucleic acid analysis
|
WO2007115242A2
(en)
|
2006-03-31 |
2007-10-11 |
Columbia University |
Binary probes for fluorescent analysis of nucleic acids
|
US20090326041A1
(en)
|
2006-05-05 |
2009-12-31 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
DK2066684T3
(da)
|
2006-05-11 |
2012-10-22 |
Isis Pharmaceuticals Inc |
5´-Modificerede bicycliske nukleinsyreanaloge
|
WO2007134161A2
(en)
|
2006-05-11 |
2007-11-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the pcsk9 gene
|
CA2651946A1
(en)
*
|
2006-05-12 |
2007-11-22 |
Gen-Probe Incorporated |
Compositions and methods to detect enterococci nucleic acid
|
WO2007137301A2
(en)
*
|
2006-05-23 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Modulation of chrebp expression
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
RU2553561C2
(ru)
|
2006-07-21 |
2015-06-20 |
Сайленс Терапьютикс Аг |
Средства ингибирования экспрессии протеинкиназы 3
|
US9051601B2
(en)
|
2006-08-01 |
2015-06-09 |
Gen-Probe Incorporated |
Methods of nonspecific target capture of nucleic acids
|
US20090131348A1
(en)
|
2006-09-19 |
2009-05-21 |
Emmanuel Labourier |
Micrornas differentially expressed in pancreatic diseases and uses thereof
|
WO2008036776A2
(en)
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
|
CA2663581C
(en)
|
2006-09-21 |
2016-03-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the hamp gene
|
ES2611924T3
(es)
|
2006-10-03 |
2017-05-11 |
Arbutus Biopharma Corporation |
Formulaciones que contienen lípidos
|
JP2010507387A
(ja)
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
EP2061901A2
(de)
|
2006-10-31 |
2009-05-27 |
Noxxon Pharma AG |
Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls
|
EP3095873B1
(de)
|
2006-12-21 |
2018-04-18 |
Gen-Probe Incorporated |
Verfahren und zusammensetzungen zur amplifizierung von nukleinsäuren
|
WO2008094945A2
(en)
|
2007-01-29 |
2008-08-07 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
PE20090064A1
(es)
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
CN105748480A
(zh)
|
2007-05-11 |
2016-07-13 |
宾夕法尼亚大学理事会 |
治疗皮肤溃疡的方法
|
EP2977452A3
(de)
|
2007-05-11 |
2016-05-25 |
Thomas Jefferson University |
Verfahren zur behandlung und vorbeugung von neurodegenerativen erkrankungen und störungen
|
AU2008260277C1
(en)
|
2007-05-30 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
JP5745842B2
(ja)
|
2007-06-19 |
2015-07-08 |
ストラトス ゲノミクス インコーポレイテッド |
拡張によるハイスループット核酸配列決定
|
BRPI0814189A2
(pt)
|
2007-07-05 |
2015-03-03 |
Novartis Ag |
Ácido ribonucleico de filamento duplo, composição farmacêutica e seus usos, método para inibir a expressão de fosfatidilinositol 4-cinase, vetor e uso de um composto que seletivamente inibe a atividade da fosfatidilinositol 4-cinase.
|
ES2376507T5
(es)
*
|
2007-07-05 |
2015-08-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos 6-disustituidos
|
EP2188298B1
(de)
|
2007-08-15 |
2013-09-18 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyrannukleinsäureanaloga
|
CA2700953A1
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
US8614309B2
(en)
|
2007-10-03 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
Double-stranded RNA directed to CASP2 and methods of use thereof
|
EP2222851B1
(de)
|
2007-11-20 |
2017-06-28 |
Ionis Pharmaceuticals, Inc. |
Modulation der cd40-expression
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
US7595164B2
(en)
|
2007-12-26 |
2009-09-29 |
Gen-Probe Incorporated |
Compositions and methods to detect Candida albicans nucleic acid
|
EP2944649A1
(de)
|
2008-01-10 |
2015-11-18 |
Research Development Foundation |
Impfstoffe und diagnostika für ehrlichiosen
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
AU2009222056A1
(en)
*
|
2008-03-01 |
2009-09-11 |
Abraxis Bioscience, Llc |
Treatment, diagnostic, and method for discovering antagonist using SPARC specific miRNAs
|
US8426378B2
(en)
*
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
DK2285819T3
(da)
*
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
EP2274423A2
(de)
*
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Bicyclische nukleoside umfassende oligomere verbindungen mit verringerter toxizität
|
CA2721183C
(en)
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
JP2011519951A
(ja)
*
|
2008-05-07 |
2011-07-14 |
アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー |
miRNAによる薬物治療の増強
|
US8258111B2
(en)
|
2008-05-08 |
2012-09-04 |
The Johns Hopkins University |
Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
|
US20100209957A1
(en)
*
|
2008-06-20 |
2010-08-19 |
Genvault Corporation |
Biosample storage devices and methods of use thereof
|
WO2010017509A1
(en)
*
|
2008-08-07 |
2010-02-11 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression for the treatment of cns related disorders
|
CN102177237B
(zh)
|
2008-09-12 |
2013-10-30 |
金沃特公司 |
用于贮存和稳定生物分子的基质和介质
|
JP2012513953A
(ja)
|
2008-09-23 |
2012-06-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
|
EP2361256B1
(de)
*
|
2008-09-24 |
2013-04-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenylverbindungen als nukleinsäureanaloga
|
US8501805B2
(en)
*
|
2008-09-24 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-L-bicyclic nucleosides
|
AU2009305636A1
(en)
|
2008-10-15 |
2010-04-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of Factor 11 expression
|
AU2009308217B2
(en)
|
2008-10-24 |
2016-01-21 |
Ionis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
EP2447274B1
(de)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomerverbindungen und Verfahren
|
EP2350131B1
(de)
|
2008-11-07 |
2017-06-07 |
Research Development Foundation |
Zusammensetzungen und methoden zur inhibierung der cripto/grp78-komplexbildung und signalvermittlung
|
KR20220150995A
(ko)
|
2008-11-10 |
2022-11-11 |
알닐람 파마슈티칼스 인코포레이티드 |
치료제 운반용 신규 지질 및 조성물
|
BRPI0920985A2
(pt)
|
2008-11-21 |
2015-08-18 |
Univ Columbia |
Enzima de dna dividida para tipificação visual de polimorfismo de nucleotídeo único
|
KR101881596B1
(ko)
|
2008-12-02 |
2018-07-24 |
웨이브 라이프 사이언시스 재팬 인코포레이티드 |
인 원자 변형된 핵산의 합성 방법
|
US20110288155A1
(en)
|
2008-12-18 |
2011-11-24 |
Elena Feinstein |
Sirna compounds and methods of use thereof
|
US8853134B2
(en)
|
2009-01-28 |
2014-10-07 |
The Trustees Of Columbia University In The City Of New York |
Microarrays of binary nucleic acid probes for detecting nucleic acid analytes
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
EP2393825A2
(de)
|
2009-02-06 |
2011-12-14 |
Isis Pharmaceuticals, Inc. |
Oligomere verbindungen und verfahren
|
WO2010091878A2
(en)
|
2009-02-13 |
2010-08-19 |
Silence Therapeutics Ag |
Means for inhibiting the expression of opa1
|
US8829179B2
(en)
|
2009-02-18 |
2014-09-09 |
Silence Therapeutics Gmbh |
Means for inhibiting the expression of ANG2
|
US8975389B2
(en)
|
2009-03-02 |
2015-03-10 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
AU2010226466A1
(en)
*
|
2009-03-20 |
2011-10-20 |
Alios Biopharma, Inc. |
Substituted nucleoside and nucleotide analogs
|
US20110045080A1
(en)
*
|
2009-03-24 |
2011-02-24 |
William Marsh Rice University |
Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
|
EP2258858A1
(de)
|
2009-06-05 |
2010-12-08 |
Universitätsklinikum Freiburg |
Für LSD1 transgenisches Tiermodell für Krebs
|
CN104873464B
(zh)
|
2009-06-10 |
2018-06-22 |
阿布特斯生物制药公司 |
改进的脂质制剂
|
WO2011003020A1
(en)
|
2009-07-01 |
2011-01-06 |
Gen-Probe Incorporated |
Methods and compositions for nucleic acid amplification
|
IN2012DN00720A
(de)
|
2009-07-06 |
2015-06-19 |
Ontorii Inc |
|
US9512164B2
(en)
|
2009-07-07 |
2016-12-06 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide end caps
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
EP2462153B1
(de)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexosenukleinsäureanaloga
|
AP2015008874A0
(en)
|
2009-08-14 |
2015-11-30 |
Alnylam Pharmaceuticals Inc |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
JP2013511990A
(ja)
|
2009-11-26 |
2013-04-11 |
クォーク ファーマシューティカルズ インコーポレーティッド |
末端置換を含むsiRNA化合物
|
CA3044884A1
(en)
|
2009-12-07 |
2011-06-16 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
US8778904B2
(en)
|
2009-12-09 |
2014-07-15 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the CNS
|
KR101692063B1
(ko)
|
2009-12-09 |
2017-01-03 |
닛토덴코 가부시키가이샤 |
hsp47 발현의 조절
|
US20130017223A1
(en)
|
2009-12-18 |
2013-01-17 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
EP3604558B1
(de)
|
2010-02-17 |
2022-10-12 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von atopobium-vaginae-nukleinsäure
|
WO2011108930A1
(en)
|
2010-03-04 |
2011-09-09 |
Interna Technologies Bv |
A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
CA3074551C
(en)
|
2010-04-21 |
2021-05-04 |
Gen-Probe Incorporated |
Compositions, methods and kits to detect herpes simplex virus nucleic acids
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
US9156873B2
(en)
|
2010-04-28 |
2015-10-13 |
Isis Pharmaceuticals, Inc. |
Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
|
EP2625186B1
(de)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
ES2625689T3
(es)
|
2010-04-29 |
2017-07-20 |
Ionis Pharmaceuticals, Inc. |
Modulación de la expresión de transtiretina
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
KR102095478B1
(ko)
|
2010-05-28 |
2020-04-01 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
KR101553753B1
(ko)
|
2010-06-24 |
2015-09-16 |
쿠아크 파마수티칼스 인코퍼레이티드 |
Rhoa에 대한 이중 가닥 rna 및 그의 용도
|
EP2588629B1
(de)
|
2010-06-30 |
2017-05-17 |
Gen-Probe Incorporated |
Methode und apparatur zur identifizierung von analyt-beinhaltenden proben unter verwendung von single-read determination des analyten und prozesskontrollsignalen
|
CA2804599C
(en)
|
2010-07-06 |
2023-01-31 |
Interna Technologies Bv |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
EP3305920B1
(de)
|
2010-07-12 |
2020-02-12 |
Gen-Probe Incorporated |
Zusammensetzungen und assays zur erkennung von saisonaler h3-influenza a-virus-nukleinsäure
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
CA2807440A1
(en)
|
2010-08-04 |
2012-02-09 |
Cizzle Biotechnology Limited |
Methods and compounds for the diagnosis and treatment of cancer
|
WO2012030856A2
(en)
|
2010-08-30 |
2012-03-08 |
Gen-Probe Incorporated |
Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
|
US10017763B2
(en)
|
2010-09-03 |
2018-07-10 |
Sarepta Therapeutics, Inc. |
dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
|
EP3327140A1
(de)
|
2010-09-16 |
2018-05-30 |
Gen-Probe Incorporated |
Über l-nukleotidenden immobilisierbare fängersonden
|
KR20130110170A
(ko)
|
2010-09-22 |
2013-10-08 |
앨리오스 바이오파마 인크. |
치환된 뉴클레오타이드 유사체
|
US10428019B2
(en)
|
2010-09-24 |
2019-10-01 |
Wave Life Sciences Ltd. |
Chiral auxiliaries
|
EP3438289A1
(de)
|
2010-10-04 |
2019-02-06 |
Gen-Probe Prodesse, Inc. |
Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
|
US20140134231A1
(en)
|
2010-10-11 |
2014-05-15 |
Sanford-Burnham Medical Research Institute |
Mir-211 expression and related pathways in human melanoma
|
US9255293B2
(en)
|
2010-11-01 |
2016-02-09 |
Gen-Probe Incorporated |
Integrated capture and amplification of target nucleic acid for sequencing
|
US8569220B2
(en)
|
2010-11-12 |
2013-10-29 |
Jelmar, Llc |
Hard surface cleaning composition
|
EP2640853B1
(de)
|
2010-11-17 |
2018-12-26 |
Ionis Pharmaceuticals, Inc. |
Modulation von alpha-synukleinexpression
|
CA2818024C
(en)
|
2010-12-06 |
2019-09-24 |
Quark Pharmaceuticals, Inc. |
Double stranded oligonucleotide compounds comprising positional modifications
|
WO2012099755A1
(en)
|
2011-01-11 |
2012-07-26 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
EP2474617A1
(de)
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
MIR zur Behandlung von Neoangiogenese
|
CA2828002A1
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating lung disease and injury
|
US9487778B2
(en)
|
2011-03-03 |
2016-11-08 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
US9512467B2
(en)
|
2011-03-10 |
2016-12-06 |
Gen-Probe Incorporated |
Methods and compositions for the selection and optimization of oligonucleotide tag sequences
|
EP3604559A1
(de)
|
2011-04-25 |
2020-02-05 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US20140227293A1
(en)
|
2011-06-30 |
2014-08-14 |
Trustees Of Boston University |
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
|
CN103703148B
(zh)
|
2011-07-15 |
2021-03-12 |
简.探针公司 |
在单路或多路测定法中用于检测人细小病毒核酸和用于检测甲型肝炎病毒核酸的组合物和方法
|
BR112014001244A2
(pt)
|
2011-07-19 |
2017-02-21 |
Wave Life Sciences Pte Ltd |
métodos para a síntese de ácidos nucléicos funcionalizados
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
EP3640332A1
(de)
|
2011-08-29 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Oligomer-konjugat-komplexe und deren verwendung
|
AU2012304537B2
(en)
|
2011-09-06 |
2015-08-20 |
Gen-Probe Incorporated |
Closed nucleic acid structures
|
EP2753714B1
(de)
|
2011-09-06 |
2017-04-12 |
Gen-Probe Incorporated |
Zirkularisierte schablonen zur sequenzierung
|
EP2753713B1
(de)
|
2011-09-08 |
2017-07-19 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
|
US9644241B2
(en)
|
2011-09-13 |
2017-05-09 |
Interpace Diagnostics, Llc |
Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
|
WO2013049328A1
(en)
|
2011-09-27 |
2013-04-04 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
WO2013063519A1
(en)
|
2011-10-26 |
2013-05-02 |
Asuragen, Inc. |
Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
|
EP2773758B1
(de)
|
2011-11-03 |
2017-06-07 |
Quark Pharmaceuticals, Inc. |
Zusammensetzungen zur neuroprotektion
|
AU2012318290B2
(en)
|
2011-11-04 |
2015-07-30 |
Gen-Probe Incorporated |
Molecular assay reagents and methods
|
US20140323549A1
(en)
|
2011-11-08 |
2014-10-30 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the nervous system
|
EP2780299A4
(de)
|
2011-11-18 |
2015-04-22 |
Sarepta Therapeutics Inc |
Funktionsmodifizierte oligonukleotide und untereinheiten davon
|
DE102011120550B4
(de)
|
2011-12-05 |
2013-11-07 |
Gen-Probe Prodesse, Inc. |
Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
|
US8980865B2
(en)
|
2011-12-22 |
2015-03-17 |
Alios Biopharma, Inc. |
Substituted nucleotide analogs
|
EP2794881B1
(de)
|
2011-12-22 |
2018-06-27 |
InteRNA Technologies B.V. |
Mirna zur behandlung von kopf-hals-karzinom
|
MX356509B
(es)
|
2011-12-22 |
2018-05-30 |
Alios Biopharma Inc |
Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
|
EP2797632A1
(de)
|
2012-01-01 |
2014-11-05 |
QBI Enterprises Ltd. |
Auf endo180 gezielte partikel zur selektiven verabreichung von therapie- und diagnosemitteln
|
CA2858630A1
(en)
|
2012-01-12 |
2013-07-18 |
Quark Pharmaceuticals, Inc. |
Combination therapy for treating hearing and balance disorders
|
CA2863084C
(en)
|
2012-02-01 |
2020-07-07 |
Gen-Probe Incorporated |
Asymmetric hairpin target capture oligomers
|
WO2013123996A1
(en)
|
2012-02-24 |
2013-08-29 |
Astrazeneca Uk Limited |
Novel sirna inhibitors of human icam-1
|
CN104411714A
(zh)
|
2012-03-09 |
2015-03-11 |
韦斯塔隆公司 |
毒肽产生、植物中的肽表达和富含半胱氨酸的肽的组合
|
EP2639238A1
(de)
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclische Nukleoside und daraus hergestellte oligomere Verbindungen
|
US8916538B2
(en)
|
2012-03-21 |
2014-12-23 |
Vertex Pharmaceuticals Incorporated |
Solid forms of a thiophosphoramidate nucleotide prodrug
|
USRE48171E1
(en)
|
2012-03-21 |
2020-08-25 |
Janssen Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
US9441007B2
(en)
|
2012-03-21 |
2016-09-13 |
Alios Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
EP2827876A4
(de)
|
2012-03-22 |
2015-10-28 |
Alios Biopharma Inc |
Pharmazeutische kombinationen mit einem thionucleotidanalog
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2850092B1
(de)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclische nukleinsäureanaloga
|
AU2013205110B2
(en)
|
2012-04-24 |
2016-10-13 |
Gen-Probe Incorporated |
Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
|
EP2854813B1
(de)
|
2012-05-31 |
2018-07-25 |
Bio-lab Ltd. |
Pyrazolotriazolylnukleosidanaloga und oligonukleotide damit
|
AU2013205064B2
(en)
|
2012-06-04 |
2015-07-30 |
Gen-Probe Incorporated |
Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
|
BR112015000784A8
(pt)
|
2012-07-13 |
2018-04-03 |
Wave Life Sciences Japan |
Grupo auxiliar assimétrico
|
AU2013205087B2
(en)
|
2012-07-13 |
2016-03-03 |
Gen-Probe Incorporated |
Method for detecting a minority genotype
|
AU2013202793B2
(en)
|
2012-07-31 |
2014-09-18 |
Gen-Probe Incorporated |
System, method and apparatus for automated incubation
|
US9139870B2
(en)
|
2012-08-30 |
2015-09-22 |
Gen-Probe Incorporated |
Multiphase nucleic acid amplification
|
US9611474B2
(en)
|
2012-09-12 |
2017-04-04 |
Quark Pharmaceuticals, Inc. |
Double-stranded oligonucleotide molecules to DDIT4 and methods of use thereof
|
WO2014043292A1
(en)
|
2012-09-12 |
2014-03-20 |
Quark Pharmaceuticals, Inc. |
Double-stranded oligonucleotide molecules to p53 and methods of use thereof
|
WO2014043291A1
(en)
|
2012-09-12 |
2014-03-20 |
Quark Pharmaceuticals, Inc. |
Double-stranded nucleic acid compounds
|
WO2014045126A2
(en)
|
2012-09-18 |
2014-03-27 |
Uti Limited Partnership |
Treatment of pain by inhibition of usp5 de-ubiquitinase
|
US20140100124A1
(en)
|
2012-10-04 |
2014-04-10 |
Asuragen, Inc. |
Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
|
AU2013205122B2
(en)
|
2012-10-11 |
2016-11-10 |
Gen-Probe Incorporated |
Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2014072357A1
(en)
|
2012-11-06 |
2014-05-15 |
Interna Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
|
AU2013205090B2
(en)
|
2012-12-07 |
2016-07-28 |
Gen-Probe Incorporated |
Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
|
US10398661B2
(en)
|
2013-02-28 |
2019-09-03 |
The Board Of Regents Of The University Of Texas System |
Methods for classifying a cancer as susceptible to TMEPAI-directed therapies and treating such cancers
|
JP6479759B2
(ja)
|
2013-03-14 |
2019-03-06 |
アーノルド, ライル, ジェイ.ARNOLD, Lyle, J. |
固体支持体上での核酸増幅方法
|
EP4163387A1
(de)
|
2013-03-15 |
2023-04-12 |
The University of Chicago |
Verfahren und zusammensetzungen in zusammenhang mit t-zell-aktivität
|
EP2971134B1
(de)
|
2013-03-15 |
2023-10-25 |
Aegea Biotechnologies, Inc. |
Verfahren zur amplifizierung fragmentierter zielnukleinsäuren mittels einer assemblersequenz
|
CA2905527C
(en)
|
2013-03-15 |
2023-10-03 |
Lyle J. Arnold |
Methods for amplification of nucleic acids utilizing clamp oligonucleotides
|
CA2918194C
(en)
|
2013-03-27 |
2022-12-06 |
The General Hospital Corporation |
Methods and agents for treating alzheimer's disease
|
EA031393B1
(ru)
|
2013-05-01 |
2018-12-28 |
Ионис Фармасьютикалз, Инк. |
Композиции и способы модулирования экспрессии hbv и ttr
|
WO2015015498A1
(en)
|
2013-07-31 |
2015-02-05 |
Qbi Enterprises Ltd. |
Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
|
EP3027222A1
(de)
|
2013-07-31 |
2016-06-08 |
QBI Enterprises Ltd. |
Sphingolipid-polyalkylamin-oligonukleotidverbindungen
|
US10053742B2
(en)
|
2013-08-14 |
2018-08-21 |
Gen-Probe Incorporated |
Compositions and methods for detecting HEV nucleic acid
|
EP2853595A1
(de)
|
2013-09-30 |
2015-04-01 |
Soluventis GmbH |
NOTCH 1-spezifische siRNA-Moleküle
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
CA2929555A1
(en)
|
2013-11-08 |
2015-05-14 |
Baylor Research Institute |
Nuclear localization of glp-1 stimulates myocardial regeneration and reverses heart failure
|
CA2931829A1
(en)
|
2013-12-02 |
2015-06-11 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
KR20230152178A
(ko)
|
2014-01-16 |
2023-11-02 |
웨이브 라이프 사이언시스 리미티드 |
키랄 디자인
|
US10087444B2
(en)
|
2014-02-13 |
2018-10-02 |
The Board Of Regents Of The University Of Texas System |
MicroRNA composition for the treatment of neuroblastoma
|
WO2015142910A1
(en)
|
2014-03-17 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
US10006027B2
(en)
|
2014-03-19 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating Ataxin 2 expression
|
AU2015231130C1
(en)
|
2014-03-19 |
2021-12-23 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating Ataxin 2 expression
|
AU2015240761B2
(en)
|
2014-04-01 |
2019-09-12 |
Biogen Ma Inc. |
Compositions for modulating SOD-1 expression
|
US10221416B2
(en)
|
2014-04-24 |
2019-03-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
EP3647318B1
(de)
|
2014-04-28 |
2021-06-30 |
Ionis Pharmaceuticals, Inc. |
Verbindungsmodifizierte oligomerverbindungen
|
CA2946003A1
(en)
|
2014-05-01 |
2015-11-05 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating angiopoietin-like 3 expression
|
BR112016022593B1
(pt)
|
2014-05-01 |
2022-04-26 |
Ionis Pharmaceuticals, Inc |
Compostos oligoméricos, composições que os compreendem, e usos dos mesmos
|
HRP20220379T1
(hr)
|
2014-06-10 |
2022-05-27 |
Erasmus University Medical Center Rotterdam |
Antisense oligonukleotidi korisni u liječenju pompeove bolesti
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
WO2016044271A2
(en)
|
2014-09-15 |
2016-03-24 |
Children's Medical Center Corporation |
Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
|
US20170304459A1
(en)
|
2014-10-10 |
2017-10-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
EP3739062B1
(de)
|
2014-10-20 |
2023-08-16 |
Gen-Probe Incorporated |
Lyselösung roter blutkörperchen
|
WO2016083624A1
(en)
|
2014-11-28 |
2016-06-02 |
Silence Therapeutics Gmbh |
Means for inhibiting the expression of edn1
|
WO2016094845A2
(en)
|
2014-12-12 |
2016-06-16 |
Woolf Tod M |
Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
|
WO2016100716A1
(en)
|
2014-12-18 |
2016-06-23 |
Vasant Jadhav |
Reversirtm compounds
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
EP3242956B1
(de)
|
2015-01-09 |
2020-06-17 |
Gen-Probe Incorporated |
Verfahren und zusammensetzungen zur diagnose von bakterieller vaginose
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
US11421229B2
(en)
|
2015-02-20 |
2022-08-23 |
Baylor College Of Medicine |
p63 inactivation for the treatment of heart failure
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
US10550438B2
(en)
|
2015-03-16 |
2020-02-04 |
Gen-Probe Incorporated |
Methods and compositions for detecting bacterial nucleic acid
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
EP3302489A4
(de)
|
2015-06-04 |
2019-02-06 |
Sarepta Therapeutics, Inc. |
Verfahren und verbindungen zur behandlung von krankheiten und leiden im zusammenhang mit lymphozyten
|
AU2016295168B2
(en)
|
2015-07-17 |
2021-08-19 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
US10533175B2
(en)
|
2015-09-25 |
2020-01-14 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Ataxin 3 expression
|
BR112018007611A2
(pt)
|
2015-10-14 |
2018-10-23 |
Bio Path Holding Inc |
ácidos nucleicos p-etóxi para formulação lipossômica
|
WO2017079739A1
(en)
|
2015-11-06 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
MODULATING APOLIPOPROTEIN (a) EXPRESSION
|
US11058709B1
(en)
|
2015-12-04 |
2021-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
AU2015416656B2
(en)
|
2015-12-07 |
2023-02-23 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for Pompe disease
|
US11111549B2
(en)
|
2016-01-04 |
2021-09-07 |
Gen-Probe Incorporated |
Methods and compositions for detecting Candida species
|
AU2017205462A1
(en)
|
2016-01-05 |
2018-06-07 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing LRRK2 expression
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
US10577607B2
(en)
|
2016-03-16 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Modulation of DYRK1B expression
|
CA3019635A1
(en)
|
2016-03-31 |
2017-10-05 |
Baylor Research Institute |
Angiopoietin-like protein 8 (angptl8)
|
EP3228326A1
(de)
|
2016-04-05 |
2017-10-11 |
Silence Therapeutics GmbH |
Nucleinsäure verbunden mit einem dreiwertigen glykokonjugat
|
WO2017181088A1
(en)
|
2016-04-14 |
2017-10-19 |
University Of Florida Research Foundation, Incorporated |
Use of mir-223-3p as a cancer therapeutic and method for treating cancer using the same
|
US11236339B2
(en)
|
2016-06-17 |
2022-02-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of GYS1 expression
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
BR112019005166A2
(pt)
|
2016-09-16 |
2019-07-02 |
Bio Path Holding Inc |
terapia de combinação com oligonucleotídeos antisense lipossômicos
|
KR20190065341A
(ko)
|
2016-10-06 |
2019-06-11 |
아이오니스 파마수티컬즈, 인코포레이티드 |
올리고머 화합물들의 접합 방법
|
WO2018075633A2
(en)
|
2016-10-19 |
2018-04-26 |
Gen-Probe Incorporated |
Compositions and methods for detecting or quantifying hepatitis c virus
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
EP3541959A1
(de)
|
2016-11-21 |
2019-09-25 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des hepatitis-b-virus
|
EP3548620A4
(de)
|
2016-12-02 |
2020-07-22 |
Cold Spring Harbor Laboratory |
Modulation der lnc05-expression
|
BR112019012825A2
(pt)
|
2016-12-22 |
2019-11-26 |
Intellia Therapeutics Inc |
composições e métodos para tratar deficiência de alfa-1 antitripsina
|
US11197928B2
(en)
|
2017-01-13 |
2021-12-14 |
Board Of Regents, The University Of Texas System |
Sustained production of high affinity antigen specific antibody by high dose BAFF receptor-targeting mAb-siRNA conjugate
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
CA3057154A1
(en)
|
2017-03-24 |
2018-09-27 |
Gen-Probe Incorporated |
Compositions and methods for detecting or quantifying parainfluenza virus
|
CA3056135C
(en)
|
2017-03-25 |
2024-02-20 |
Gen-Probe Incorporated |
Compositions, methods and kits to detect adenovirus nucleic acids
|
EP3385272A1
(de)
|
2017-04-05 |
2018-10-10 |
Silence Therapeutics GmbH |
Weitere neuartige oligonukleotid-ligand-konjugate
|
WO2018185252A1
(en)
|
2017-04-05 |
2018-10-11 |
Silence Therapeutics Gmbh |
Nucleic acid conjugates
|
WO2018185253A1
(en)
|
2017-04-05 |
2018-10-11 |
Silence Therapeutics Gmbh |
Ligand modified double-stranded nucleic acids
|
WO2018209068A1
(en)
|
2017-05-11 |
2018-11-15 |
Gen-Probe Incorporated |
Compositions and methods for isolating target nucleic acids
|
JP7292217B2
(ja)
|
2017-06-07 |
2023-06-16 |
ジーイーエヌ-プローブ・インコーポレーテッド |
試料中のバベシア種の核酸の検出
|
EP3651893B1
(de)
|
2017-07-10 |
2023-11-15 |
Gen-Probe Incorporated |
Analytische systeme und verfahren zur nukleinsäure-amplifikation mit der verwendung von den proben zugeteilten parametern
|
EP4219766A3
(de)
|
2017-08-11 |
2023-10-11 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von staphylococcus aureus
|
US11197884B2
(en)
|
2017-08-18 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
AR113154A1
(es)
|
2017-09-29 |
2020-01-29 |
Intellia Therapeutics Inc |
Polinucleótidos, composiciones y métodos para edición del genoma
|
AU2018338787A1
(en)
|
2017-09-29 |
2020-04-16 |
Intellia Therapeutics, Inc. |
Compositions and methods for TTR gene editing and treating ATTR amyloidosis
|
CN111601900A
(zh)
|
2017-11-02 |
2020-08-28 |
詹森生物制药有限公司 |
寡核苷酸构建体及其用途
|
CA3079524A1
(en)
|
2017-11-03 |
2019-05-09 |
Interna Technologies B.V. |
Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
CA3082909C
(en)
|
2017-11-17 |
2023-07-25 |
Gen-Probe Incorporated |
Compositions and methods for detecting c1orf43 nucleic acid
|
US11662281B2
(en)
|
2017-12-13 |
2023-05-30 |
Gen-Probe Incorporated |
Compositions and methods for biological sample processing
|
EP3724354A1
(de)
|
2017-12-15 |
2020-10-21 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
CN111902537A
(zh)
|
2018-01-15 |
2020-11-06 |
Ionis制药公司 |
Dnm2表达的调节剂
|
US20190233816A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
CA3089078A1
(en)
|
2018-01-29 |
2019-08-01 |
Gen-Probe Incorporated |
Analytical systems and methods
|
US20210038732A1
(en)
|
2018-02-12 |
2021-02-11 |
Interna Technologies B.V. |
Anticancer microrna and lipid formulations thereof
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
BR112020016001A2
(pt)
|
2018-03-02 |
2020-12-15 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão irf4
|
WO2019183440A1
(en)
|
2018-03-22 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
EP3549610A1
(de)
|
2018-04-05 |
2019-10-09 |
Silence Therapeutics GmbH |
Nukleinsäurekonjugate
|
CN112041440A
(zh)
|
2018-04-11 |
2020-12-04 |
Ionis制药公司 |
Ezh2表达的调节剂
|
CU20200082A7
(es)
|
2018-05-09 |
2021-06-08 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para la reducción de la expresión de fxi
|
SG11202010215TA
(en)
|
2018-05-09 |
2020-11-27 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn3 expression
|
CA3103442A1
(en)
|
2018-06-13 |
2019-12-19 |
Gen-Probe Incorporated |
Compositions and methods for detecting group b streptococcus nucleic acid
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
WO2020006267A1
(en)
|
2018-06-27 |
2020-01-02 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing lrrk2 expression
|
US20210317515A1
(en)
|
2018-07-10 |
2021-10-14 |
Gen-Probe Incorporated |
Methods and systems for detecting and quantifying nucleic acids
|
AR115847A1
(es)
|
2018-07-25 |
2021-03-03 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para reducir la expresión de la atxn2
|
MX2021001070A
(es)
|
2018-07-31 |
2021-05-27 |
Intellia Therapeutics Inc |
Composiciones y métodos para editar el gen hidroxiácido oxidasa 1 (hao1) para tratar la hiperoxaluria primaria tipo 1 (ph1).
|
CA3106975A1
(en)
|
2018-08-01 |
2020-02-06 |
Gen-Probe Incorporated |
Compositions and methods for detecting nucleic acids of epstein-barr virus
|
EP3841223A1
(de)
|
2018-08-08 |
2021-06-30 |
Gen-Probe Incorporated |
Zusammensetzungen, verfahren und kits zum nachweis von mycoplasma genitalium
|
EP3833762A4
(de)
|
2018-08-09 |
2022-09-28 |
Verseau Therapeutics, Inc. |
Oligonukleotidzusammensetzungen zum targeting von ccr2 und csf1r und verwendungen davon
|
JP2021534758A
(ja)
|
2018-08-21 |
2021-12-16 |
ジェン−プローブ・インコーポレーテッド |
ヒトサイトメガロウイルスを増幅、検出、または定量化するための組成物および方法
|
JP7389111B2
(ja)
|
2018-08-24 |
2023-11-29 |
ジェン-プローブ・インコーポレーテッド |
細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
|
CA3112651A1
(en)
|
2018-09-27 |
2020-04-02 |
Gen-Probe Incorporated |
Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
|
SG11202102660RA
(en)
|
2018-09-28 |
2021-04-29 |
Intellia Therapeutics Inc |
Compositions and methods for lactate dehydrogenase (ldha) gene editing
|
JP2022512703A
(ja)
|
2018-10-16 |
2022-02-07 |
インテリア セラピューティクス,インコーポレイテッド |
免疫療法のための組成物および方法
|
AU2019361203A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Compositions and methods for transgene expression from an albumin locus
|
BR112021007289A2
(pt)
|
2018-10-18 |
2021-07-27 |
Intellia Therapeutics, Inc. |
composições e métodos para tratar deficiência de alfa-1 antitripsina
|
AU2019360269A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Nucleic acid constructs and methods of use
|
AU2019360270A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Compositions and methods for expressing factor IX.
|
JP2022508954A
(ja)
|
2018-10-22 |
2022-01-19 |
ジェン-プローブ・インコーポレーテッド |
ヒトポリオーマウイルスbkウイルスを増幅、検出または定量化するための組成物および方法
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
AU2019380940A1
(en)
|
2018-11-15 |
2021-06-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of IRF5 expression
|
TW202030333A
(zh)
|
2018-12-20 |
2020-08-16 |
美商簡 探針公司 |
用於檢測瘧原蟲物種核酸之組成物及方法
|
KR20210122809A
(ko)
|
2019-01-31 |
2021-10-12 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Yap1 발현의 조절인자
|
BR112021015323A2
(pt)
|
2019-02-27 |
2021-10-05 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de malat1
|
EP3942078A1
(de)
|
2019-03-22 |
2022-01-26 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zur detektion von gruppe-a-streptococcus
|
EP3947670A2
(de)
|
2019-03-28 |
2022-02-09 |
Intellia Therapeutics, Inc. |
Polynukleotide, zusammensetzungen und verfahren zur expression von polypeptiden
|
KR20220004648A
(ko)
|
2019-03-28 |
2022-01-11 |
인텔리아 테라퓨틱스, 인크. |
Ttr 가이드 rna, 및 rna-가이드 dna 결합제를 암호화하는 폴리뉴클레오티드를 포함하는 조성물 및 방법
|
WO2020198706A1
(en)
|
2019-03-28 |
2020-10-01 |
Intellia Therapeutics, Inc. |
Compositions and methods for ttr gene editing and treating attr amyloidosis comprising a corticosteroid or use thereof
|
WO2020205463A1
(en)
|
2019-03-29 |
2020-10-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating ube3a-ats
|
CA3176699A1
(en)
|
2019-05-03 |
2020-11-12 |
Gen-Probe Incorporated |
Receptacle transport system for an analytical system
|
CA3144452A1
(en)
|
2019-07-03 |
2021-01-07 |
Gen-Probe Incorporated |
Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
|
EP3956450A4
(de)
|
2019-07-26 |
2022-11-16 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation von gfap
|
EP4013767A4
(de)
|
2019-08-15 |
2023-10-25 |
Ionis Pharmaceuticals, Inc. |
Verbindungsmodifizierte oligomere verbindungen und ihre verwendungen
|
US20220298548A1
(en)
|
2019-08-23 |
2022-09-22 |
Gen-Probe Incorporated |
Compositions, methods and kits for detecting treponema pallidum
|
TW202118873A
(zh)
|
2019-08-27 |
2021-05-16 |
美商維泰克斯製藥公司 |
用於治療與重複性dna有關之病症之組合物及方法
|
CA3153514A1
(en)
|
2019-09-05 |
2021-03-11 |
Gen-Probe Incorporated |
Detection of chlamydia trachomatis nucleic acid variants
|
EP4058187A1
(de)
|
2019-11-14 |
2022-09-21 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum einfangen von zielnukleinsäuren
|
SG10201914033YA
(en)
|
2019-12-31 |
2021-07-29 |
Wilmar International Ltd |
Polypeptides with Lipase Activity and Uses Thereof
|
EP4342999A3
(de)
|
2020-01-16 |
2024-04-24 |
DNAe Diagnostics Limited |
Zusammensetzungen, kits und verfahren zur isolierung von zielpolynukleotiden
|
CA3165815A1
(en)
|
2020-01-31 |
2021-08-05 |
Ming Huang |
Use of liquid chromatography and mass spectrometry to characterize oligonucleotides
|
CR20220485A
(es)
|
2020-02-28 |
2022-11-10 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
BR112022021676A2
(pt)
|
2020-04-28 |
2023-01-31 |
Intellia Therapeutics Inc |
Métodos de distribuição de célula in vitro
|
TW202206596A
(zh)
|
2020-05-01 |
2022-02-16 |
美商Ionis製藥公司 |
調節atxn1之化合物及方法
|
US20230220499A1
(en)
|
2020-05-07 |
2023-07-13 |
Grifols Diagnostic Solutions Inc. |
Methods and compositions for detecting sars-cov-2 nucleic acid
|
EP3922720A1
(de)
|
2020-06-09 |
2021-12-15 |
Universidad de Murcia |
Therapie zur verhinderung unerwünschter kardialer remodellierung nach einem akuten myokardinfarkt
|
BR112022024206A2
(pt)
|
2020-06-29 |
2023-01-03 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para modular plp1
|
US20230243001A1
(en)
|
2020-07-17 |
2023-08-03 |
Gen-Probe Incorporated |
Detection of Macrolide-Resistant Mycoplasma Genitalium
|
WO2022034555A1
(en)
|
2020-08-13 |
2022-02-17 |
Janssen Biopharma, Inc. |
Polynucleotide constructs and uses thereof
|
US20220096606A1
(en)
|
2020-09-09 |
2022-03-31 |
Vertex Pharmaceuticals Incorporated |
Compositions and Methods for Treatment of Duchenne Muscular Dystrophy
|
CN116323440A
(zh)
|
2020-10-21 |
2023-06-23 |
简·探针公司 |
流体容器管理系统
|
US20230414648A1
(en)
|
2020-11-06 |
2023-12-28 |
Vertex Pharmaceuticals Incorporated |
Compositions and Methods for Treatment of DM1 with SLUCAS9 and SACAS9
|
US11447521B2
(en)
|
2020-11-18 |
2022-09-20 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
KR20230129996A
(ko)
|
2020-12-11 |
2023-09-11 |
인텔리아 테라퓨틱스, 인크. |
탈아미노화를 포함하는 게놈 편집을 위한 폴리뉴클레오타이드,조성물 및 방법
|
AU2021396403A1
(en)
|
2020-12-11 |
2023-06-29 |
Intellia Therapeutics, Inc. |
Compositions and methods for reducing mhc class ii in a cell
|
WO2022140586A2
(en)
|
2020-12-23 |
2022-06-30 |
Intellia Therapeutics, Inc. |
Compositions and methods for reducing hla-a in a cell
|
CA3205042A1
(en)
|
2020-12-23 |
2022-06-30 |
Intellia Therapeutics, Inc. |
Compositions and methods for genetically modifying ciita in a cell
|
IL304069A
(en)
|
2020-12-30 |
2023-08-01 |
Intellia Therapeutics Inc |
Engineered T cells
|
WO2022155521A1
(en)
|
2021-01-15 |
2022-07-21 |
Board Of Regents, The University Of Texas System |
A trans-complementation system for sars-cov-2
|
WO2022170172A1
(en)
|
2021-02-08 |
2022-08-11 |
Intellia Therapeutics, Inc. |
Natural killer cell receptor 2b4 compositions and methods for immunotherapy
|
JP2024505678A
(ja)
|
2021-02-08 |
2024-02-07 |
インテリア セラピューティクス,インコーポレイテッド |
免疫療法のためのリンパ球活性化遺伝子3(lag3)組成物及び方法
|
EP4288089A2
(de)
|
2021-02-08 |
2023-12-13 |
Intellia Therapeutics, Inc. |
T-zell immunglobulin und mucin domäne 3 (tim3) zusammensetzungen und verfahren zur immuntherapie
|
TW202302848A
(zh)
|
2021-02-26 |
2023-01-16 |
美商維泰克斯製藥公司 |
以crispr/sacas9治療第1型肌強直性營養不良之組合物及方法
|
TW202246510A
(zh)
|
2021-02-26 |
2022-12-01 |
美商維泰克斯製藥公司 |
以crispr/slucas9治療第1型肌強直性營養不良之組合物及方法
|
JP2024510996A
(ja)
|
2021-03-15 |
2024-03-12 |
ジェン-プローブ・インコーポレーテッド |
生物学的サンプル処理のための組成物および方法
|
WO2022204476A1
(en)
|
2021-03-26 |
2022-09-29 |
The Board Of Regents Of The University Of Texas System |
Nucleotide editing to reframe dmd transcripts by base editing and prime editing
|
WO2022229851A1
(en)
|
2021-04-26 |
2022-11-03 |
Crispr Therapeutics Ag |
Compositions and methods for using slucas9 scaffold sequences
|
WO2022234519A1
(en)
|
2021-05-05 |
2022-11-10 |
Crispr Therapeutics Ag |
Compositions and methods for using sacas9 scaffold sequences
|
CN117500815A
(zh)
|
2021-06-18 |
2024-02-02 |
Ionis制药公司 |
用于降低ifnar1表达的化合物和方法
|
TW202327626A
(zh)
|
2021-06-22 |
2023-07-16 |
美商英特利亞醫療公司 |
用於體內編輯肝臟基因之方法
|
GB202110479D0
(en)
|
2021-07-21 |
2021-09-01 |
Dnae Diagnostics Ltd |
Compositions, kits and methods for sequencing target polynucleotides
|
GB202110485D0
(en)
|
2021-07-21 |
2021-09-01 |
Dnae Diagnostics Ltd |
Compositions, kits and methods for sequencing target polynucleotides
|
WO2023002203A1
(en)
|
2021-07-21 |
2023-01-26 |
Dnae Diagnostics Limited |
Method and system comprising a cartridge for sequencing target polynucleotides
|
CA3226812A1
(en)
|
2021-07-27 |
2023-02-02 |
Gen-Probe Incorporated |
Compositions and methods for detecting gastrointestinal pathogens
|
WO2023018637A1
(en)
|
2021-08-09 |
2023-02-16 |
Vertex Pharmaceuticals Incorporated |
Gene editing of regulatory elements
|
WO2023028471A1
(en)
|
2021-08-24 |
2023-03-02 |
Intellia Therapeutics, Inc. |
Programmed cell death protein 1 (pd1) compositions and methods for cell-based therapy
|
WO2023039444A2
(en)
|
2021-09-08 |
2023-03-16 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exon 51 for treatment of duchenne muscular dystrophy
|
US20230193406A1
(en)
|
2021-09-22 |
2023-06-22 |
Herbalife International Of America, Inc. |
Methods and compositions for processing botanical materials
|
WO2023081689A2
(en)
|
2021-11-03 |
2023-05-11 |
Intellia Therapeutics, Inc. |
Polynucleotides, compositions, and methods for genome editing
|
WO2023081200A2
(en)
|
2021-11-03 |
2023-05-11 |
Intellia Therapeutics, Inc. |
Cd38 compositions and methods for immunotherapy
|
WO2023172927A1
(en)
|
2022-03-08 |
2023-09-14 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exon 44, 50, and 53 for treatment of duchenne muscular dystrophy
|
WO2023172926A1
(en)
|
2022-03-08 |
2023-09-14 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exons for treatment of duchenne muscular dystrophy
|
WO2023185697A2
(en)
|
2022-03-29 |
2023-10-05 |
Accuredit Therapeutics (Suzhou) Co., Ltd. |
Compositions and methods for treatment of transthyretin amyloidosis
|
WO2023205606A1
(en)
|
2022-04-18 |
2023-10-26 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for enhancing aav therapy and decreasing tropism of aav to the liver
|
WO2023205148A1
(en)
|
2022-04-19 |
2023-10-26 |
Intellia Therapeutics, Inc. |
Chimeric antigen receptor compositions and uses
|
WO2023245113A1
(en)
|
2022-06-16 |
2023-12-21 |
Intellia Therapeutics, Inc. |
Methods and compositions for genetically modifying a cell
|
WO2023245108A2
(en)
|
2022-06-16 |
2023-12-21 |
Intellia Therapeutics, Inc. |
Compositions and methods for reducing mhc class i in a cell
|
WO2023245109A2
(en)
|
2022-06-16 |
2023-12-21 |
Intellia Therapeutics, Inc. |
Compositions and methods for genomic editing
|
WO2024006955A1
(en)
|
2022-06-29 |
2024-01-04 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
WO2024020352A1
(en)
|
2022-07-18 |
2024-01-25 |
Vertex Pharmaceuticals Incorporated |
Tandem guide rnas (tg-rnas) and their use in genome editing
|
EP4311579A1
(de)
|
2022-07-29 |
2024-01-31 |
Association Française contre les Myopathies |
B-zell-spezifische mabsirna-konjugate verbessern myasthenie
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024035952A1
(en)
|
2022-08-12 |
2024-02-15 |
Remix Therapeutics Inc. |
Methods and compositions for modulating splicing at alternative splice sites
|
WO2024054924A1
(en)
|
2022-09-08 |
2024-03-14 |
Gen-Probe Incorporated |
Method of detecting nucleic acid analytes using dual-specificity primers
|
WO2024061296A2
(en)
|
2022-09-22 |
2024-03-28 |
Accuredit Therapeutics (Suzhou) Co., Ltd. |
Compositions and methods for treatment of hypercholesterolemia and/or cardiovascular disease
|