DE69230243D1 - Enzymatische neutralisierung von heparin - Google Patents

Enzymatische neutralisierung von heparin

Info

Publication number
DE69230243D1
DE69230243D1 DE69230243T DE69230243T DE69230243D1 DE 69230243 D1 DE69230243 D1 DE 69230243D1 DE 69230243 T DE69230243 T DE 69230243T DE 69230243 T DE69230243 T DE 69230243T DE 69230243 D1 DE69230243 D1 DE 69230243D1
Authority
DE
Germany
Prior art keywords
heparinase
heparin
neutralization
bind
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230243T
Other languages
English (en)
Other versions
DE69230243T2 (de
Inventor
Joseph Zimmermann
N Lewis
Robert Heft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ibex Technologies Inc
Original Assignee
Ibex Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ibex Technologies Inc filed Critical Ibex Technologies Inc
Publication of DE69230243D1 publication Critical patent/DE69230243D1/de
Application granted granted Critical
Publication of DE69230243T2 publication Critical patent/DE69230243T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/85—Flavobacterium
DE69230243T 1991-04-04 1992-04-03 Enzymatische neutralisierung von heparin Expired - Fee Related DE69230243T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/680,330 US5262325A (en) 1991-04-04 1991-04-04 Method for the enzymatic neutralization of heparin
PCT/US1992/002724 WO1992017203A1 (en) 1991-04-04 1992-04-03 Enzymatic neutralization of heparin

Publications (2)

Publication Number Publication Date
DE69230243D1 true DE69230243D1 (de) 1999-12-09
DE69230243T2 DE69230243T2 (de) 2000-05-11

Family

ID=24730658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230243T Expired - Fee Related DE69230243T2 (de) 1991-04-04 1992-04-03 Enzymatische neutralisierung von heparin

Country Status (11)

Country Link
US (2) US5262325A (de)
EP (1) EP0537325B1 (de)
JP (1) JP2542780B2 (de)
AT (1) ATE186217T1 (de)
AU (1) AU658418B2 (de)
CA (1) CA2083162C (de)
DE (1) DE69230243T2 (de)
DK (1) DK0537325T3 (de)
ES (1) ES2141106T3 (de)
GR (1) GR3032469T3 (de)
WO (1) WO1992017203A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726773A1 (de) * 1993-11-17 1996-08-21 Massachusetts Institute Of Technology Verfahren zur hemmung der angiogenese mittels heparinase
US5681733A (en) * 1994-06-10 1997-10-28 Ibex Technologies Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum
US5997863A (en) * 1994-07-08 1999-12-07 Ibex Technologies R And D, Inc. Attenuation of wound healing processes
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
CA2242693C (en) * 1997-09-04 2002-09-17 Becton, Dickinson And Company Additive formulation and method of use thereof
AU2002300536B2 (en) * 1997-09-04 2005-11-10 Becton, Dickinson And Company Additive formulation and method of use thereof
US5985582A (en) * 1997-12-09 1999-11-16 Sigma-Aldrich Co. Thrombin-based assay for antithrombin III
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
EP1109919A2 (de) 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Von heparinase i und ii abgeleitete heparinasen
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
CA2402160C (en) * 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
US6808701B2 (en) 2000-03-21 2004-10-26 Johnson & Johnson Consumer Companies, Inc. Conditioning compositions
US7590539B1 (en) * 2000-06-28 2009-09-15 At&T Intellectual Property I, L.P. System and method for email notification
AU2001292618A1 (en) 2000-09-12 2002-03-26 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
AU2440802A (en) 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
KR20020046293A (ko) * 2000-12-12 2002-06-21 김영식 글리코사미노글리칸을 분해하는 인간 장내 미생물 유래신규 헤파리네이즈, 그의 제조 방법 및 용도
AU2003226075B2 (en) 2002-04-12 2008-09-25 Instrumentation Laboratory Company Immunoassay probe
CA2493509C (en) * 2002-06-03 2010-03-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase b
US7699966B2 (en) 2004-05-17 2010-04-20 Medtronic, Inc. Point of care heparin determination system
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
CA2614068A1 (en) * 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
DE102005038418A1 (de) * 2005-08-12 2007-02-15 Dade Behring Marburg Gmbh Faktor Xa-basierter Heparinassay unter Verwendung einer Heparin-modifizierenden Komponente
WO2008039382A2 (en) * 2006-09-21 2008-04-03 Kyphon Sarl Diammonium phosphate and other ammonium salts and their use in preventing clotting
JP2011133396A (ja) * 2009-12-25 2011-07-07 Sysmex Corp 活性化部分トロンボプラスチン時間測定試薬、活性化部分トロンボプラスチン時間測定方法、及び血液凝固抑制物質の有無の判定方法
DE102010025970A1 (de) * 2010-07-02 2012-01-05 Papst Licensing Gmbh & Co. Kg Verfahren zur Bestimmung von Proteasen und ihren Proformen
DE102010025972A1 (de) * 2010-07-02 2012-01-05 Papst Licensing Gmbh & Co. Kg Verfahren zur Bestimmung von Proteasen und ihren Proformen
EP2484775A1 (de) 2011-02-07 2012-08-08 Siemens Healthcare Diagnostics Products GmbH Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
JP2022525742A (ja) 2019-03-14 2022-05-19 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥用ローディングトレイ組立体及びシステム

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950133A (en) * 1971-10-20 1976-04-13 Mallinckrodt, Inc. Reagent formulations for assaying biological specimens and methods of preparing and using same
US4795703A (en) * 1986-03-07 1989-01-03 The Children's Medical Center Corporation Heparin assay
WO1988002400A1 (en) * 1986-10-02 1988-04-07 Massachusetts Institute Of Technology Neutralizing anticoagulant activities of low molecular weight heparin
ATE81021T1 (de) * 1987-03-10 1992-10-15 Massachusetts Inst Technology Neutralisierung von heparin.
US4863611A (en) 1987-04-30 1989-09-05 Massachusetts Institute Of Technology Extracorporeal reactors containing immobilized species
JP2726275B2 (ja) * 1988-08-24 1998-03-11 生化学工業株式会社 グリコサミノグリカン分解酵素の精製法
JPH0693836B2 (ja) * 1988-11-25 1994-11-24 新技術事業団 バチルス属に属するヘパリナーゼ生産微生物、新規ヘパリナーゼ及びその製法

Also Published As

Publication number Publication date
US5262325A (en) 1993-11-16
AU658418B2 (en) 1995-04-13
CA2083162C (en) 1998-08-11
EP0537325B1 (de) 1999-11-03
GR3032469T3 (en) 2000-05-31
JP2542780B2 (ja) 1996-10-09
ES2141106T3 (es) 2000-03-16
WO1992017203A1 (en) 1992-10-15
EP0537325A1 (de) 1993-04-21
JPH05507297A (ja) 1993-10-21
DE69230243T2 (de) 2000-05-11
AU1771392A (en) 1992-11-02
CA2083162A1 (en) 1992-10-05
US5338677A (en) 1994-08-16
ATE186217T1 (de) 1999-11-15
DK0537325T3 (da) 2000-01-10

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: IBEX TECHNOLOGIES, INC., MONTREAL, QUEBEC, CA

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee