DE69228291T2 - Verfahren und Vorrichtung zum Nachweis von Molekülen - Google Patents

Verfahren und Vorrichtung zum Nachweis von Molekülen

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Publication number
DE69228291T2
DE69228291T2 DE69228291T DE69228291T DE69228291T2 DE 69228291 T2 DE69228291 T2 DE 69228291T2 DE 69228291 T DE69228291 T DE 69228291T DE 69228291 T DE69228291 T DE 69228291T DE 69228291 T2 DE69228291 T2 DE 69228291T2
Authority
DE
Germany
Prior art keywords
molecules
detection
test
molecular structure
associated target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69228291T
Other languages
English (en)
Other versions
DE69228291D1 (de
Inventor
Mitchell D Eggers
Michael E Hogan
Kenneth Loren Beattie
John Shumaker
Daniel J Ehrlich
Mark Hollis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Houston Advanced Research Center HARC
Massachusetts Institute of Technology
Original Assignee
Baylor College of Medicine
Houston Advanced Research Center HARC
Massachusetts Institute of Technology
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Filing date
Publication date
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Application filed by Baylor College of Medicine, Houston Advanced Research Center HARC, Massachusetts Institute of Technology filed Critical Baylor College of Medicine
Publication of DE69228291D1 publication Critical patent/DE69228291D1/de
Application granted granted Critical
Publication of DE69228291T2 publication Critical patent/DE69228291T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6832Enhancement of hybridisation reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251Colorimeters; Construction thereof
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/221Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance by investigating the dielectric properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/226Construction of measuring vessels; Electrodes therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00511Walls of reactor vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
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    • B01J2219/00596Solid-phase processes
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    • B01J2219/00614Delimitation of the attachment areas
    • B01J2219/00621Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00623Immobilisation or binding
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    • B01J2219/00583Features relative to the processes being carried out
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    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00637Introduction of reactive groups to the surface by coating it with another layer
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00603Making arrays on substantially continuous surfaces
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    • B01J2219/00709Type of synthesis
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809Multifield plates or multicontainer arrays
DE69228291T 1991-11-19 1992-11-10 Verfahren und Vorrichtung zum Nachweis von Molekülen Expired - Lifetime DE69228291T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79403691A 1991-11-19 1991-11-19

Publications (2)

Publication Number Publication Date
DE69228291D1 DE69228291D1 (de) 1999-03-11
DE69228291T2 true DE69228291T2 (de) 1999-06-02

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Country Status (6)

Country Link
US (3) US5532128A (de)
EP (1) EP0543550B1 (de)
JP (1) JP3310705B2 (de)
AT (1) ATE176324T1 (de)
DE (1) DE69228291T2 (de)
IL (1) IL103674A0 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8007744B2 (en) 2003-01-17 2011-08-30 Greiner Bio-One Gmbh Sample container for analyses
US9005549B2 (en) 2003-01-17 2015-04-14 Greiner Bio-One Gmbh High throughput polymer-based microarray slide

Families Citing this family (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US6943034B1 (en) * 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
JPH05236997A (ja) * 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US20030044777A1 (en) * 1993-10-28 2003-03-06 Kenneth L. Beattie Flowthrough devices for multiple discrete binding reactions
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US5627749A (en) * 1994-02-25 1997-05-06 Rohrback Cosasco Systems, Inc. Corrosion monitoring tool
US7625697B2 (en) 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US7857957B2 (en) * 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
WO1997021094A1 (en) * 1995-12-01 1997-06-12 Innogenetics N.V. Impedimetric detection system and method of production thereof
US6228575B1 (en) * 1996-02-08 2001-05-08 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
US6924094B1 (en) 1996-02-08 2005-08-02 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
EP1728875A3 (de) * 1996-02-08 2007-05-09 Affymetrix, Inc. Speziesbestimmung und phenotypische Charakterisierung von Mikroorganismen auf der Basis eines Chips
US6063633A (en) 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
WO1997033000A1 (en) 1996-03-04 1997-09-12 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US5721435A (en) * 1996-04-09 1998-02-24 Hewlett Packard Company Methods and apparatus for measuring optical properties of biological and chemical substances
AU711564B2 (en) * 1996-04-17 1999-10-14 Motorola, Inc. Transistor-based molecular detection apparatus and method
US6706875B1 (en) * 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6251691B1 (en) * 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US5728532A (en) * 1996-05-31 1998-03-17 Ackley; Donald E. Electrode configuration for matrix addressing of a molecular detection device
US5914613A (en) 1996-08-08 1999-06-22 Cascade Microtech, Inc. Membrane probing system with local contact scrub
AU4327697A (en) * 1996-08-20 1998-03-06 Motorola, Inc. Method and apparatus for detecting predetermined molecular structures in a sample
US5858666A (en) * 1996-08-29 1999-01-12 Biotechnology Research And Development Corporation Apparatus and method of detection employing an AC frequency sensor array
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
WO1998020020A2 (en) 1996-11-06 1998-05-14 Sequenom, Inc. High density immobilization of nucleic acids
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
EP0938674B1 (de) * 1996-11-16 2005-06-01 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
AU6646398A (en) * 1996-12-31 1998-07-31 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US5954931A (en) * 1997-01-24 1999-09-21 Motorola, Inc. Electrophoresis apparatus and method involving parallel channels
FR2759165A1 (fr) * 1997-01-31 1998-08-07 Canon Kk Procede et dispositif de determination de la quantite de produit present dans un reservoir, reservoir de produit et dispositif de traitement de signaux electriques destines a un tel dispositif de determination
US6469779B2 (en) * 1997-02-07 2002-10-22 Arcturus Engineering, Inc. Laser capture microdissection method and apparatus
US6495195B2 (en) 1997-02-14 2002-12-17 Arcturus Engineering, Inc. Broadband absorbing film for laser capture microdissection
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6110748A (en) * 1997-04-30 2000-08-29 Motorola, Inc. Optical storage medium for binding assays
US5935785A (en) * 1997-04-30 1999-08-10 Motorola, Inc. Binding assay methods
US5968728A (en) * 1997-04-30 1999-10-19 Motorola, Inc. Molecular detection devices and methods of forming same
US7220550B2 (en) * 1997-05-14 2007-05-22 Keensense, Inc. Molecular wire injection sensors
US6060327A (en) * 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US6699667B2 (en) 1997-05-14 2004-03-02 Keensense, Inc. Molecular wire injection sensors
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
IL121312A (en) * 1997-07-14 2001-09-13 Technion Res & Dev Foundation Microelectronic components, their manufacture and electronic networks containing them
EP1004015B1 (de) * 1997-08-15 2004-01-02 Alexion Pharmaceuticals, Inc. Vorrichtung zur durchführung von nachweisen an reaktionsstellen
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
DE19741716A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
US7075640B2 (en) * 1997-10-01 2006-07-11 Arcturus Bioscience, Inc. Consumable for laser capture microdissection
US6048692A (en) * 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US6013513A (en) * 1997-10-30 2000-01-11 Motorola, Inc. Molecular detection apparatus
US6203758B1 (en) * 1997-11-10 2001-03-20 Bio-Pixel Ltd. Micro-circuit system with array of functionalized micro-electrodes
US6123819A (en) * 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
US6268131B1 (en) 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
AU746580B2 (en) * 1997-12-17 2002-05-02 Ecole Polytechnique Federale De Lausanne Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6368795B1 (en) 1998-02-02 2002-04-09 Signature Bioscience, Inc. Bio-assay device and test system for detecting molecular binding events
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US7794946B1 (en) 1998-02-04 2010-09-14 Life Technologies Corporation Microarray and uses therefor
IL124322A (en) * 1998-05-04 2002-05-23 Technion Res & Dev Foundation Detection of an entity in a sample
US20030203394A1 (en) * 1998-05-04 2003-10-30 Yoav Eichen Detection of a target in a sample
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
AU4833899A (en) * 1998-06-24 2000-01-10 Therasense, Inc. Multi-sensor array for electrochemical recognition of nucleotide sequences and methods
US6256882B1 (en) 1998-07-14 2001-07-10 Cascade Microtech, Inc. Membrane probing system
US6483112B1 (en) 1998-07-14 2002-11-19 E. Neil Lewis High-throughput infrared spectroscopy
ATE472097T1 (de) * 1998-07-14 2010-07-15 Us Gov Health & Human Serv Infrarotspektroskopie mit hohem durchsatz
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6107038A (en) * 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US7071324B2 (en) * 1998-10-13 2006-07-04 Brown University Research Foundation Systems and methods for sequencing by hybridization
IL126776A (en) * 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
WO2000024941A1 (en) * 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
US6377894B1 (en) 1998-11-30 2002-04-23 Abbott Laboratories Analyte test instrument having improved calibration and communication processes
US6438497B1 (en) 1998-12-11 2002-08-20 Symyx Technologies Method for conducting sensor array-based rapid materials characterization
US6477479B1 (en) 1998-12-11 2002-11-05 Symyx Technologies Sensor array for rapid materials characterization
AU3691700A (en) * 1998-12-11 2000-07-03 Symyx Technologies, Inc. Sensor array-based system and method for rapid materials characterization
US6690464B1 (en) 1999-02-19 2004-02-10 Spectral Dimensions, Inc. High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units
US6716578B1 (en) 1999-03-08 2004-04-06 Bioforce Nanosciences, Inc. Method for solid state genome analysis
AU4058500A (en) * 1999-03-30 2000-10-16 Nanogen, Inc. Single nucleotide polymorphic discrimination by electronic dot blot assay on semiconductor microchips
US6399303B1 (en) 1999-04-07 2002-06-04 Integrated Nano-Technologies, Llc High resolution DNA detection methods and devices
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6518056B2 (en) 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
WO2000066994A2 (en) 1999-04-29 2000-11-09 Arcturus Engineering, Inc. Processing technology for lcm samples
US6238909B1 (en) * 1999-05-04 2001-05-29 Motorola, Inc. Method and apparatus for obtaining electric field-enhanced bioconjugation
DE60029802T2 (de) * 1999-05-14 2007-01-18 Iris Biotechnologies, Inc., Santa Clara Reversibel immobilisierung von liganden an metalloberflächen, deren herstellung und verwendung als biosensoren
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
AU5459000A (en) 1999-06-03 2000-12-28 Lockheed Martin Corporation Highly sensitive biological agent probe
US6572825B1 (en) * 1999-10-04 2003-06-03 Sandia Corporation Apparatus for thermally evolving chemical analytes from a removable substrate
DE60045739D1 (de) * 1999-06-25 2011-04-28 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US7045287B2 (en) * 1999-07-20 2006-05-16 Agilent Technologies, Inc. Method for contacting fluid components with moieties on a surface
ES2319380T3 (es) 1999-07-26 2009-05-07 Clinical Micro Sensors, Inc. Determinacion de secuencias de acido nucleico usando la deteccion electronica.
US7179638B2 (en) * 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
JP4861584B2 (ja) * 1999-10-01 2012-01-25 ソフィオン・バイオサイエンス・アクティーゼルスカブ イオンチャネルの電気生理的性質を測定及び/または監視するための基体及び方法
US7364920B2 (en) * 1999-10-27 2008-04-29 Technion Research And Development Foundation Ltd. Method for gold deposition
JP2001133436A (ja) * 1999-11-01 2001-05-18 Microtec Nition:Kk マトリックス型電気化学発光用基板
US6690470B1 (en) 1999-11-04 2004-02-10 Arcturus Engineering, Inc. Automated laser capture microdissection
US6423535B1 (en) 1999-11-24 2002-07-23 Incyte Genomics, Inc. Normalization control for hybridization reactions
CA2389268A1 (en) 1999-11-24 2001-06-14 Incyte Genomics, Inc. Normalization controls and duplex probes for quantitative hybridization reactions
CA2393733A1 (en) * 1999-12-09 2001-06-14 Motorola, Inc. Methods and compositions relating to electrical detection of nucleic acid reactions
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
DE10002595A1 (de) * 2000-01-21 2001-08-09 Infineon Technologies Ag Messverfahren und Sensorvorrichtung für die chemische und pharmazeutische Analytik und Synthese
CA2401640A1 (en) * 2000-02-01 2001-08-09 Jaymie Robin Sawyer Detection and differentiation of bacteria using electrical detection methods
US9335328B2 (en) * 2000-02-03 2016-05-10 Instant Medical Diagnostics, Llc Method and apparatus for signal transduction pathway profiling
GB0002859D0 (en) * 2000-02-08 2000-03-29 Molecular Sensing Plc Process for characterising nucleic acids in solution
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
US6413722B1 (en) 2000-03-22 2002-07-02 Incyte Genomics, Inc. Polymer coated surfaces for microarray applications
DE10015547C2 (de) * 2000-03-30 2002-02-14 Aventis Res & Tech Gmbh & Co Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US8232582B2 (en) 2000-04-24 2012-07-31 Life Technologies Corporation Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
WO2001081892A2 (en) * 2000-04-26 2001-11-01 Arcturus Engineering, Inc. Laser capture microdissection (lcm) extraction device and device carrier and method for post-lcm fluid processing
AU2001259512B2 (en) * 2000-05-04 2007-03-01 Yale University High density protein arrays for screening of protein activity
WO2001096607A2 (en) 2000-06-13 2001-12-20 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ATE319087T1 (de) 2000-06-21 2006-03-15 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US7270954B1 (en) 2000-06-30 2007-09-18 Iris Biotechnologies, Inc. Hybridization of target DNA with immobilized nucleic acid analogs
DE10032207C2 (de) * 2000-07-03 2002-10-31 Univ Karlsruhe Verfahren, Vorrichtung und Computerprogrammprodukt zur Bestimmung zumindest einer Eigenschaft einer Testemulsion und/oder Testsuspension sowie Verwendung der Vorrichtung
TW513485B (en) * 2000-07-10 2002-12-11 Ind Tech Res Inst On-spot hydrophilic enhanced slide and preparation thereof
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
WO2002012558A1 (en) * 2000-08-07 2002-02-14 Azur Environmental Ltd. Method of an apparatus for the detection of analytes
US7008769B2 (en) * 2000-08-15 2006-03-07 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer
US6900013B1 (en) 2000-08-25 2005-05-31 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
EP1387894A4 (de) * 2000-08-24 2006-10-11 Aviva Biosciences Corp Verfahren und zusammensetzung zur identifikation von nukleinsäuremolekülen mit hilfe von nukleolytischen aktivitäten und hybridisierung
US20030190612A1 (en) * 2000-08-31 2003-10-09 Nobuko Yamamoto Detecting method and detection substrate for use therein
US6914423B2 (en) 2000-09-05 2005-07-05 Cascade Microtech, Inc. Probe station
US6965226B2 (en) 2000-09-05 2005-11-15 Cascade Microtech, Inc. Chuck for holding a device under test
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
WO2002025288A2 (en) * 2000-09-22 2002-03-28 Clontech Laboratories Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
CA2426686A1 (en) 2000-10-30 2002-07-18 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
DE10054487A1 (de) * 2000-11-03 2002-05-23 Eppendorf Ag Verfahren und Vorrichtung zum Temperieren von Proben
DE10143173A1 (de) 2000-12-04 2002-06-06 Cascade Microtech Inc Wafersonde
US6887667B2 (en) * 2000-12-28 2005-05-03 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to identify small variations of biomolecules
US20030077598A1 (en) * 2001-01-04 2003-04-24 Phan Brigitte Chau Dual bead assays including covalent linkages for improved specificity and related optical analysis discs
US20020127855A1 (en) * 2001-01-04 2002-09-12 Sauer Jon Robert Method for fabricating a pattern in a mask on a surface of an object and product manufactured thereby
US7435384B2 (en) * 2001-01-08 2008-10-14 Leonard Fish Diagnostic instrument with movable electrode mounting member and methods for detecting analytes
JPWO2002066969A1 (ja) * 2001-02-19 2004-06-24 協和メデックス株式会社 荷電成分検出装置及びその使用方法並びに検出パネル
US20020168663A1 (en) * 2001-02-27 2002-11-14 Phan Brigitte Chau Methods for DNA conjugation onto solid phase including related optical biodiscs and disc drive systems
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US7749388B2 (en) * 2001-06-15 2010-07-06 Life Technologies Corporation Low volume filtration column devices and methods of filtering therewith
US7229595B2 (en) * 2001-06-15 2007-06-12 Molecular Devices Corporation Filtration column devices and methods of filtering therewith
US7556733B2 (en) * 2001-06-15 2009-07-07 Mds Analytical Technologies (Us) Inc. Low volume filtration column devices and methods of filtering therewith
WO2003001179A2 (en) * 2001-06-21 2003-01-03 Virginia Tech Intellectual Properties, Inc. Electro-optical detection device
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US6649402B2 (en) 2001-06-22 2003-11-18 Wisconsin Alumni Research Foundation Microfabricated microbial growth assay method and apparatus
CN100465619C (zh) 2001-06-29 2009-03-04 梅索磅秤技术有限公司 发光测试检测用的检测板、读数系统和方法
US20030134273A1 (en) * 2001-07-17 2003-07-17 Eric Henderson Combined molecular binding detection through force microscopy and mass spectrometry
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
WO2003052435A1 (en) 2001-08-21 2003-06-26 Cascade Microtech, Inc. Membrane probing system
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
WO2003034029A2 (en) 2001-10-15 2003-04-24 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
WO2003053855A2 (en) * 2001-10-30 2003-07-03 University Of Delaware Rapid high-throughput screen for detecting biological species in ballast water
US10156501B2 (en) 2001-11-05 2018-12-18 Life Technologies Corporation Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
US8722357B2 (en) * 2001-11-05 2014-05-13 Life Technologies Corporation Automated microdissection instrument
US8715955B2 (en) 2004-09-09 2014-05-06 Life Technologies Corporation Laser microdissection apparatus and method
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
US20030203384A1 (en) * 2002-03-08 2003-10-30 Chafin David R. Multiplex detection of biological materials in a sample
US20030186302A1 (en) * 2002-03-29 2003-10-02 Yixin Wang Colorectal cancer diagnostics
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
EP2290368B1 (de) 2002-05-08 2012-12-19 NorthWest Biotherapeutics, Inc. Qualitätstests für antigenpräsentierende zellen
US7022287B2 (en) * 2002-05-08 2006-04-04 Sandia National Laboratories Single particle electrochemical sensors and methods of utilization
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
US7267751B2 (en) * 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7214528B1 (en) 2002-12-31 2007-05-08 Oregon Health & Sciences University Device for direct electrical detection of molecules and molecule-molecule interactions
EP1583845A4 (de) * 2003-01-02 2006-06-28 Bioforce Nanosciences Inc Verfahren und vorrichtung zur molekularen analyse bei kleinen probenvolumen
WO2005016115A2 (en) * 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
EP1452867B1 (de) * 2003-02-25 2006-06-07 Hitachi, Ltd. DNA-spezifische Kapazitiver Affinitätssensor
DE10311315A1 (de) * 2003-03-14 2004-09-30 Apibio Sas Verfahren und Vorrichtung zur Detektion von Biomolekülen
US20040191782A1 (en) * 2003-03-31 2004-09-30 Yixin Wang Colorectal cancer prognostics
JP2004309416A (ja) 2003-04-10 2004-11-04 Sony Corp センサ装置、センシング方法、生体物質のセンサ装置、生体物質のセンシング方法、分泌物のセンサ装置、分泌物のセンシング方法、感情センサ装置および感情センシング方法
US7056673B2 (en) * 2003-04-25 2006-06-06 Janssen Pharmaceutica N.V. Preservation of RNA in a biological sample
US7057404B2 (en) 2003-05-23 2006-06-06 Sharp Laboratories Of America, Inc. Shielded probe for testing a device under test
US7492172B2 (en) 2003-05-23 2009-02-17 Cascade Microtech, Inc. Chuck for holding a device under test
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
JP3788513B2 (ja) * 2003-09-11 2006-06-21 セイコーエプソン株式会社 固相基板上への分子の固定化方法およびそれを用いるバイオセンサの製造方法
US20050060100A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company Computer software and algorithms for systems biologically linked to cellular phenotype
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
US7964344B2 (en) * 2003-09-17 2011-06-21 Canon Kabushiki Kaisha Stable hybrid
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
TW200521436A (en) 2003-09-22 2005-07-01 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1671125A1 (de) * 2003-09-29 2006-06-21 Koninklijke Philips Electronics N.V. Markierungsfreier nachweis von biomolekülen
US20050069905A1 (en) * 2003-09-30 2005-03-31 Carl Myerholtz Detection of molecular binding events
US7488607B2 (en) * 2003-09-30 2009-02-10 Agilent Technologies, Inc. Electronically readable microarray with electronic addressing function
DE10346286B3 (de) 2003-10-06 2005-04-14 J. Eberspächer GmbH & Co. KG Abgasreinigungsanordnung
US7250626B2 (en) 2003-10-22 2007-07-31 Cascade Microtech, Inc. Probe testing structure
WO2005042763A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
JP2007509629A (ja) 2003-10-29 2007-04-19 バイオアレイ ソリューションズ リミテッド 二本鎖dnaの切断による複合核酸分析
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
WO2005045409A1 (ja) * 2003-11-07 2005-05-19 Osaka Prefecture 電気抵抗型検出センサおよび検出方法
US20050112587A1 (en) * 2003-11-25 2005-05-26 Sherrill James V. Analyzing biological probes
US20090029353A1 (en) * 2003-12-08 2009-01-29 Maki Wusi C Molecular detector
US7187188B2 (en) 2003-12-24 2007-03-06 Cascade Microtech, Inc. Chuck with integrated wafer support
JP2007517231A (ja) 2003-12-24 2007-06-28 カスケード マイクロテック インコーポレイテッド アクティブ・ウェハプローブ
JP3903183B2 (ja) * 2004-02-03 2007-04-11 独立行政法人物質・材料研究機構 遺伝子検出電界効果デバイスおよびこれを用いた遺伝子多型解析方法
BRPI0507376A (pt) 2004-02-06 2007-07-10 Bayer Healthcare Llc espécie oxidável como uma referência interna para biossensores e método de uso
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
SG151334A1 (en) * 2004-04-01 2009-04-30 Univ Nanyang Addressable chem/bio chip array
EP2471924A1 (de) 2004-05-28 2012-07-04 Asuragen, INC. Verfahren und Zusammensetzungen mit microRNA
KR100631213B1 (ko) 2004-05-31 2006-10-04 삼성전자주식회사 인덕턴스 소자를 이용한 바이오결합 검출 장치 및 방법
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
JP2008512680A (ja) 2004-09-13 2008-04-24 カスケード マイクロテック インコーポレイテッド 両面プロービング構造体
US20060087324A1 (en) * 2004-10-01 2006-04-27 Acreo Ab E-field mapping
ES2534303T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
ATE390562T1 (de) * 2004-11-19 2008-04-15 Ebm Papst St Georgen Gmbh & Co Anordnung mit einem luefter und einer pumpe
BRPI0518734A2 (pt) * 2004-11-30 2008-12-02 Veridex Llc prognàstico de cÂncer de pulmço
US7535247B2 (en) 2005-01-31 2009-05-19 Cascade Microtech, Inc. Interface for testing semiconductors
US7656172B2 (en) 2005-01-31 2010-02-02 Cascade Microtech, Inc. System for testing semiconductors
US20060216203A1 (en) * 2005-03-28 2006-09-28 Mds Sciex (Us) A Division Of Mds Pharma Services (Us) Inc. Multiwell sample plate with integrated impedance electrodes and connection scheme
WO2006107972A2 (en) * 2005-04-05 2006-10-12 Cornell Research Foundation, Inc. Permittivity based detection of immunobiological specific bindings in a capacitive cell of coplanar waveguide or microstrip layout using a microwave
WO2006110846A2 (en) * 2005-04-08 2006-10-19 Abeygunaratne Thusara Sugat Ch Method and device for probing changes in a membrane by applying an in-plane electric field
US20060270053A1 (en) * 2005-05-26 2006-11-30 General Electric Company Apparatus, methods, and systems having gas sensor with catalytic gate and variable bias
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
AU2006272909B2 (en) 2005-07-20 2013-02-07 Bayer Healthcare Llc Gated amperometry
JP4918237B2 (ja) * 2005-09-08 2012-04-18 株式会社Kri 生体の定量方法
BRPI0616090A2 (pt) * 2005-09-19 2011-06-07 Veridex Llc métodos e materiais para identificação da origem de um carcinoma de origem primária desconhecida
KR101477815B1 (ko) 2005-09-30 2015-01-02 바이엘 헬스케어 엘엘씨 게이트형 전압 전류 측정법
JP2009524046A (ja) * 2006-01-20 2009-06-25 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ バイオセンサセル及びバイオセンサアレイ
EP2007904A4 (de) * 2006-03-13 2009-06-10 Veridex Llc Fortpflanzung von primärzellen
EP2005148B1 (de) * 2006-03-16 2018-03-07 Universal Nanosensor Technologies Inc. Dielektrisches wahrnehmungsverfahren und -system
US7723999B2 (en) 2006-06-12 2010-05-25 Cascade Microtech, Inc. Calibration structures for differential signal probing
US7403028B2 (en) 2006-06-12 2008-07-22 Cascade Microtech, Inc. Test structure and probe for differential signals
US7764072B2 (en) 2006-06-12 2010-07-27 Cascade Microtech, Inc. Differential signal probing system
US20080012578A1 (en) * 2006-07-14 2008-01-17 Cascade Microtech, Inc. System for detecting molecular structure and events
US20100003189A1 (en) 2006-07-14 2010-01-07 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US7803588B2 (en) * 2006-09-07 2010-09-28 Abeygunaratne Thusara Sugat Chandra Method and device to probe a membrane by applying an in-plane electric field
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008036776A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US8384136B2 (en) * 2006-10-19 2013-02-26 Hewlett-Packard Development Company, L.P. Demultiplexed nanowire sensor array for detection of chemical and biological species
DE102006035392A1 (de) 2006-11-02 2008-10-16 Signature Diagnostics Ag Prognostische Marker für die Vorhersage des fünfjährigen progressionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
DE102006035388A1 (de) * 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung von Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
DE102006035393A1 (de) 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
CA2669224A1 (en) * 2006-11-21 2008-10-23 Ge Healthcare Bio-Sciences Corp. Assembling and utilizing rfid sensors in containers
JP4935425B2 (ja) * 2007-03-01 2012-05-23 ソニー株式会社 血球の定性及び/又は定量分析方法、及び血液劣化検出方法
ES2307430B1 (es) 2007-05-09 2009-10-20 Consejo Superior De Investigaciones Cientificas Biosensor y sus aplicaciones.
AU2008276308A1 (en) * 2007-07-13 2009-01-22 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus using electric field for improved biological assays
US7876114B2 (en) 2007-08-08 2011-01-25 Cascade Microtech, Inc. Differential waveguide probe
WO2009023857A1 (en) * 2007-08-15 2009-02-19 State Of Oregon By & Through The State Board Of Higher Education On Behalf Of Portland State Unv. Impedance spectroscopy of biomolecules using functionalized nanoparticles
US20110166028A1 (en) * 2007-08-28 2011-07-07 Donald Bergstrom Methods for predicting treatment response based on the expression profiles of biomarker genes in notch mediated cancers
WO2009039122A2 (en) 2007-09-17 2009-03-26 Sequenom, Inc. Integrated robotic sample transfer device
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
WO2009083814A2 (en) * 2007-12-20 2009-07-09 Koninklijke Philips Electronics N.V. Microelectronic sensor device for the detection of target particles
CN101960022A (zh) * 2008-01-22 2011-01-26 维里德克斯有限责任公司 Ⅱ期和ⅲ期结肠癌的分子分期和预后
US7932036B1 (en) 2008-03-12 2011-04-26 Veridex, Llc Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US7888957B2 (en) 2008-10-06 2011-02-15 Cascade Microtech, Inc. Probing apparatus with impedance optimized interface
JP2012507300A (ja) 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Rnaパターンを評価する方法
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes
WO2010059247A2 (en) 2008-11-21 2010-05-27 Cascade Microtech, Inc. Replaceable coupon for a probing apparatus
US8319503B2 (en) 2008-11-24 2012-11-27 Cascade Microtech, Inc. Test apparatus for measuring a characteristic of a device under test
GB2467338A (en) * 2009-01-30 2010-08-04 Sharp Kk Electrical analyte sensor with optical output
US20100204936A1 (en) * 2009-02-11 2010-08-12 Midorion Ab Probing Electrode/Solution Interfaces
WO2010125566A2 (en) 2009-04-27 2010-11-04 Technion Research And Development Foundation Ltd. Markers for cancer detection
US9771618B2 (en) * 2009-08-19 2017-09-26 Bioarray Genetics, Inc. Methods for treating breast cancer
WO2011066589A1 (en) 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings Methods and systems for isolating, storing, and analyzing vesicles
AU2011205230A1 (en) 2010-01-13 2012-08-02 Caris Life Sciences Switzerland Holdings Gmbh Detection of gastrointestinal disorders
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
EP2556172A4 (de) 2010-04-06 2013-10-30 Caris Life Sciences Luxembourg Holdings Zirkulierende biomarker für krankheiten
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US8383443B2 (en) 2010-05-14 2013-02-26 International Business Machines Corporation Non-uniform gate dielectric charge for pixel sensor cells and methods of manufacturing
EP2388336A1 (de) 2010-05-19 2011-11-23 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
NZ605420A (en) 2010-07-06 2015-02-27 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
CA2817882C (en) 2010-11-17 2022-08-23 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
JP6087293B2 (ja) 2011-01-06 2017-03-01 メソ スケール テクノロジーズ エルエルシー アッセイカートリッジ及びその使用方法
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
EP2492673A1 (de) 2011-02-28 2012-08-29 Lexogen GmbH Biosensorarray gebildet aus Knotenpunkten zwischen funktionalisierten Elektroden
CA2828532A1 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
EP2492674A1 (de) 2011-02-28 2012-08-29 Lexogen GmbH Biosensorarray gebildet aus Knotenpunkten zwischen funktionalisierten Elektroden
EP2520661A1 (de) 2011-05-02 2012-11-07 Rheinische Friedrich-Wilhelms-Universität Bonn Blutbasierte Genexpressionssignaturen bei Lungenkrebs
EP2527459A1 (de) 2011-05-02 2012-11-28 Rheinische Friedrich-Wilhelms-Universität Bonn Blutbasierte Gendetektion von nichtkleinzelligem Lungenkrebs
WO2012156515A1 (en) 2011-05-18 2012-11-22 Rheinische Friedrich-Wilhelms-Universität Bonn Molecular analysis of acute myeloid leukemia
EP2524967A1 (de) 2011-05-19 2012-11-21 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
EP2524968A1 (de) 2011-05-19 2012-11-21 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (de) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas als diagnostische biomarker zur unterscheidung gutartiger von bösartigen tumoren in der schilddrüse
AU2012340192B2 (en) 2011-11-18 2016-04-07 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
GB2501611B (en) 2012-02-21 2015-03-04 Cytonics Corp Alpha-2-macroglobulin compositions and therapeutic uses
KR101289948B1 (ko) * 2012-06-11 2013-07-26 인제대학교 산학협력단 분자 진동수 패턴을 이용한 리간드 분류 방법 및 장치
WO2014007623A1 (en) 2012-07-03 2014-01-09 Interna Technologies B.V. Diagnostic portfolio and its uses
NL1040124C2 (en) * 2012-07-15 2014-09-25 Smart Frequencies B V Method and device for impedance spectroscopy on an array of individual fluild samples present on an array of cavities in at least one printed circuit boards.
WO2014055117A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
US9758835B2 (en) 2013-03-15 2017-09-12 Baylor Research Institute Ulcerative colitis (UC)-associated colorectal neoplasia markers
WO2014144666A2 (en) 2013-03-15 2014-09-18 The University Of Chicago Methods and compositions related to t-cell activity
US9352021B2 (en) 2013-08-28 2016-05-31 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
AU2014329535B2 (en) 2013-10-03 2017-09-07 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
CA2936933A1 (en) 2014-01-25 2015-07-30 uBiome, Inc. Method and system for microbiome analysis
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
EP4242329A3 (de) 2014-12-08 2023-10-25 Berg LLC Verwendung von markern einschliesslich filamin a bei der diagnose und behandlung von prostatakrebs
EP3234982B1 (de) * 2014-12-19 2019-03-06 Siemens Healthcare Diagnostics Inc. Sensoranordnung mit anti-diffusionsregion(en) zur verlängerung der haltbarkeit
WO2016210386A1 (en) 2015-06-25 2016-12-29 Roswell Biotechnologies, Inc Biomolecular sensors and methods
US11001900B2 (en) 2015-06-30 2021-05-11 Psomagen, Inc. Method and system for characterization for female reproductive system-related conditions associated with microorganisms
AU2016288666A1 (en) 2015-06-30 2018-01-04 Psomagen, Inc. Method and system for diagnostic testing
US10712334B2 (en) 2016-01-28 2020-07-14 Roswell Biotechnologies, Inc. Massively parallel DNA sequencing apparatus
WO2017132586A1 (en) 2016-01-28 2017-08-03 Roswell Biotechnologies, Inc. Methods and apparatus for measuring analytes using large scale molecular electronics sensor arrays
CN109155354A (zh) 2016-02-09 2019-01-04 罗斯韦尔生物技术股份有限公司 电子无标签的dna和基因组测序
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
US20200185063A1 (en) 2016-06-05 2020-06-11 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
EP3568407A4 (de) 2017-01-10 2020-12-23 Roswell Biotechnologies, Inc Verfahren und system zur speicherung von dna-daten
CA3052140A1 (en) 2017-01-19 2018-07-26 Roswell Biotechnologies, Inc. Solid state sequencing devices comprising two dimensional layer materials
CN110462062A (zh) 2017-01-26 2019-11-15 俄克拉荷马医学研究基金会 系统性红斑狼疮疾病活动性、强度和急性发作的生物标志物
EP3384987A3 (de) * 2017-04-03 2018-10-24 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Gefäss zur durchführung elektrochemischer messungen und verfahren zur herstellung solch eines gefässes
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
CA3057151A1 (en) 2017-04-25 2018-11-01 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
EP4023764A3 (de) 2017-05-09 2022-09-21 Roswell Biotechnologies, Inc. Bindungssondenschaltungen für molekulare sensoren
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
US11371955B2 (en) 2017-08-30 2022-06-28 Roswell Biotechnologies, Inc. Processive enzyme molecular electronic sensors for DNA data storage
KR20200067871A (ko) 2017-10-10 2020-06-12 로스웰 바이오테크놀로지스 인코포레이티드 무증폭 dna 데이터 저장을 위한 방법, 장치 및 시스템
AU2018358016A1 (en) 2017-11-03 2020-05-07 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
AU2019339508A1 (en) 2018-09-14 2021-04-15 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
EP3867645A4 (de) 2018-10-18 2022-07-13 Oklahoma Medical Research Foundation Biomarker für krankheitsaktivitätimmunindex von systemischem lupus erythematodes (sle) zur charakterisierung der krankheitsaktivität
JP7386874B2 (ja) * 2019-01-28 2023-11-27 ビージーアイ シェンチェン シーケンシングチップ及びその製造方法
JP2022526844A (ja) 2019-04-12 2022-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 筋肉量及び酸化的代謝を増加させるための組成物及び方法
CN114127312A (zh) 2019-04-30 2022-03-01 拉利玛生物医药公司 用于测定共济蛋白替代疗法的疗效的共济蛋白敏感性标志物
JP2023525760A (ja) * 2020-05-07 2023-06-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 血漿および唾液のリキッドバイオプシープラットフォーム
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
IL307531A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for estrogen receptor (ER)-like and estrogen receptor (ER)-negative breast cancer
WO2022216798A1 (en) 2021-04-06 2022-10-13 Berg Llc Protein markers for the prognosis of breast cancer progression
IL307530A (en) 2021-04-06 2023-12-01 Bpgbio Inc Estrogen receptor-like (ER) breast cancer protein markers LUMINAL A (LA) and LUMINAL B1 (LB1)
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE407115B (sv) * 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
US4098645A (en) * 1976-02-24 1978-07-04 W. R. Grace & Co. Immobilization of proteins with polyurethane polymers
US4096645A (en) * 1976-11-08 1978-06-27 Thomas Herbert Mandl Phonetic teaching device
US4293310A (en) * 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
JPS5747493A (en) * 1980-09-02 1982-03-18 Fuji Photo Film Co Ltd Method of determining a trace amount of enzyme
JPS5747494A (en) * 1980-09-02 1982-03-18 Fuji Photo Film Co Ltd Method of determining a trace amount of enzyme
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US5064754A (en) * 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
EP0213825A3 (de) * 1985-08-22 1989-04-26 Molecular Devices Corporation Chemisch-modulierte Mehrfachkapazitanz
JPS63501446A (ja) * 1985-11-19 1988-06-02 ザ・ジョンズ・ホプキンス・ユニバ−シティ/アプライド・フィジクス・ラボラトリ− 化学分析および測定用容量センサ−
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
US4728882A (en) * 1986-04-01 1988-03-01 The Johns Hopkins University Capacitive chemical sensor for detecting certain analytes, including hydrocarbons in a liquid medium
US4935207A (en) * 1986-04-01 1990-06-19 The Johns Hopkins University Capacitive chemical sensor using an ion exchange surface
US4963245A (en) * 1986-05-02 1990-10-16 Ciba Corning Diagnostics Corp. Unitary multiple electrode sensor
US4943471A (en) * 1986-05-20 1990-07-24 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Patterned thin film and process for preparing the same
US5001051A (en) * 1986-12-12 1991-03-19 Regents Of The University Of California Dose critical in-vivo detection of anti-cancer drug levels in blood
GB2202045B (en) * 1987-03-10 1991-08-21 Pa Consulting Services Improvements relating to sensors for performing assays
US4769121A (en) * 1987-05-01 1988-09-06 Biotronic Systems Corporation Sintered pellet with biochemically active layer
US5114674A (en) * 1987-05-01 1992-05-19 Biotronic Systems Corporation Added array of molecular chains for interfering with electrical fields
US5082627A (en) * 1987-05-01 1992-01-21 Biotronic Systems Corporation Three dimensional binding site array for interfering with an electrical field
DE3801987A1 (de) * 1988-01-23 1989-07-27 Boehringer Mannheim Gmbh Traeger zur chemischen oder/und enzymatischen umsetzung von nukleinsaeuren oder nukleinsaeurefragmenten an festphasen
US4938742A (en) * 1988-02-04 1990-07-03 Smits Johannes G Piezoelectric micropump with microvalves
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
DE58907327D1 (de) * 1988-06-01 1994-05-05 Deutsche Aerospace Vorrichtung mit Träger besonderer Struktur zur Aufnahme, Untersuchung und Behandlung von Proben.
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
WO1990005300A1 (en) * 1988-11-10 1990-05-17 Midwest Research Technologies, Inc. Method for electrical detection of a binding reaction
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8007744B2 (en) 2003-01-17 2011-08-30 Greiner Bio-One Gmbh Sample container for analyses
US9005549B2 (en) 2003-01-17 2015-04-14 Greiner Bio-One Gmbh High throughput polymer-based microarray slide

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US5532128A (en) 1996-07-02
IL103674A0 (en) 1993-04-04
ATE176324T1 (de) 1999-02-15
US5670322A (en) 1997-09-23
JP3310705B2 (ja) 2002-08-05
EP0543550A1 (de) 1993-05-26
JPH05322817A (ja) 1993-12-07
EP0543550B1 (de) 1999-01-27
US5891630A (en) 1999-04-06

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