US5623065A
(en)
*
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
US5955589A
(en)
*
|
1991-12-24 |
1999-09-21 |
Isis Pharmaceuticals Inc. |
Gapped 2' modified oligonucleotides
|
US6399754B1
(en)
*
|
1991-12-24 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides
|
US5149797A
(en)
*
|
1990-02-15 |
1992-09-22 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of rna and production of encoded polypeptides
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
US5965722A
(en)
*
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
WO1994008003A1
(en)
*
|
1991-06-14 |
1994-04-14 |
Isis Pharmaceuticals, Inc. |
ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
US5700922A
(en)
*
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
US20070032446A1
(en)
*
|
1991-12-24 |
2007-02-08 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
US5856455A
(en)
*
|
1991-12-24 |
1999-01-05 |
Isis Pharmaceuticals, Inc. |
Gapped 2'-modified oligonucleotides
|
US6277603B1
(en)
|
1991-12-24 |
2001-08-21 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
EP1695979B1
(de)
*
|
1991-12-24 |
2011-07-06 |
Isis Pharmaceuticals, Inc. |
Durch DNA-Abschnitte unterbrochene modifizierte Oligonukleotide
|
US6346614B1
(en)
*
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
US5652355A
(en)
*
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
TW244371B
(de)
*
|
1992-07-23 |
1995-04-01 |
Tri Clover Inc |
|
US5523389A
(en)
*
|
1992-09-29 |
1996-06-04 |
Isis Pharmaceuticals, Inc. |
Inhibitors of human immunodeficiency virus
|
JPH08506724A
(ja)
*
|
1992-12-04 |
1996-07-23 |
アポロン・インコーポレーテッド |
白血病治療のための化合物および方法
|
CA2159350A1
(en)
*
|
1993-03-31 |
1994-10-13 |
Sudhir Agrawal |
Modified oligonucleotides having improved anti-influenza activity
|
EP1897942A1
(de)
*
|
1993-05-11 |
2008-03-12 |
The University Of North Carolina At Chapel Hill |
Antisense-Oligonukleotide zur Bekämpfung fehlerhafter Spleißungen und Verwendungsverfahren dafür
|
US6410322B1
(en)
*
|
1993-07-27 |
2002-06-25 |
Hybridon Inc |
Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
|
US6605708B1
(en)
|
1993-07-28 |
2003-08-12 |
Hybridon, Inc. |
Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
CA2171553A1
(en)
*
|
1993-09-28 |
1995-04-06 |
Charles A. Marotta |
Using antisense oligonucleotides to modulate nerve growth and to reverse .beta./a4 amyloid-induced morphology
|
NZ277617A
(en)
*
|
1993-11-16 |
1998-01-26 |
Genta Inc |
Chimeric oligonucleoside compounds useful in activating rnaseh mediated cleavage of ribonucleic acid sequences
|
AU8102694A
(en)
*
|
1993-11-17 |
1995-06-06 |
Id Biomedical Corporation |
Cycling probe cleavage detection of nucleic acid sequences
|
US5550047A
(en)
*
|
1994-02-18 |
1996-08-27 |
University Of Massachusetts |
Oligonucleotides with anti-Epstein-Barr virus activity
|
US5801235A
(en)
*
|
1994-05-25 |
1998-09-01 |
Hybridon, Inc. |
Oligonucleotides with anti-cytomegalovirus activity
|
US5691316A
(en)
*
|
1994-06-01 |
1997-11-25 |
Hybridon, Inc. |
Cyclodextrin cellular delivery system for oligonucleotides
|
US6645943B1
(en)
|
1994-10-25 |
2003-11-11 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
US5591721A
(en)
*
|
1994-10-25 |
1997-01-07 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
US6608035B1
(en)
*
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
US6509149B2
(en)
*
|
1995-06-06 |
2003-01-21 |
Hybridon, Inc. |
HPV-specific oligonucleotides
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
US20030055240A1
(en)
*
|
1995-06-06 |
2003-03-20 |
Roberts Peter C. |
HPV specific oligonucleotides
|
US7074768B2
(en)
|
1995-08-17 |
2006-07-11 |
Idera Pharmaceuticals, Inc. |
Modified protein kinase A-specific oligonucleotides and methods of their use
|
US6624293B1
(en)
|
1995-08-17 |
2003-09-23 |
Hybridon, Inc. |
Modified protein kinase A-specific oligonucleotides and methods of their use
|
US5652356A
(en)
*
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
JP4293636B2
(ja)
|
1996-02-14 |
2009-07-08 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
糖修飾ギャップ付オリゴヌクレオチド
|
US9096636B2
(en)
*
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US20040161777A1
(en)
*
|
1996-06-06 |
2004-08-19 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US20030044941A1
(en)
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
US5856462A
(en)
*
|
1996-09-10 |
1999-01-05 |
Hybridon Incorporated |
Oligonucleotides having modified CpG dinucleosides
|
US5886165A
(en)
*
|
1996-09-24 |
1999-03-23 |
Hybridon, Inc. |
Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
WO1999001579A1
(en)
|
1997-07-01 |
1999-01-14 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
US6013786A
(en)
*
|
1997-08-22 |
2000-01-11 |
Hybridon, Inc. |
MDM2-specific antisense oligonucleotides
|
US20030036516A1
(en)
*
|
1997-09-10 |
2003-02-20 |
Sudhir Agrawal |
Method for using oligonucleotides having modified cpg dinucleotides
|
US6306831B1
(en)
|
1997-09-12 |
2001-10-23 |
Qik Technologies, Inc. |
Transplacental delivery of oligonucleotides
|
US7321828B2
(en)
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
US20040186071A1
(en)
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
US6841539B1
(en)
|
1998-05-21 |
2005-01-11 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
EP1080103A4
(de)
|
1998-05-21 |
2003-07-02 |
Isis Pharmaceuticals Inc |
Zubereitungen und verfahren zur nicht-parenteralen verabreichung von oligonukleotiden
|
US5962672A
(en)
*
|
1998-09-18 |
1999-10-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of RhoB expression
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
JP2003523166A
(ja)
|
1998-09-29 |
2003-08-05 |
ガミダ セル リミテッド |
幹細胞および前駆細胞の増殖と分化を制御する方法
|
US5977341A
(en)
*
|
1998-11-20 |
1999-11-02 |
Isis Pharmaceuticals Inc. |
Antisense modulation of inhibitor-kappa B kinase-beta expression
|
US5962673A
(en)
*
|
1998-11-20 |
1999-10-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of inhibitor-kappa B kinase-alpha expression
|
US5959097A
(en)
*
|
1998-11-20 |
1999-09-28 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of MEK2 expression
|
US5981732A
(en)
*
|
1998-12-04 |
1999-11-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-13 expression
|
US6127124A
(en)
*
|
1999-01-20 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
Fluorescence based nuclease assay
|
JP2002539833A
(ja)
|
1999-03-31 |
2002-11-26 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
カリンレギュレーターroc1およびroc2をコードする単離dna、それらによってコードされた単離タンパク質、ならびにそれらの利用法
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
US6046321A
(en)
*
|
1999-04-09 |
2000-04-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-i1 expression
|
US6013788A
(en)
*
|
1999-04-09 |
2000-01-11 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Smad3 expression
|
US20030078216A1
(en)
*
|
1999-05-03 |
2003-04-24 |
Macleod A. Robert |
Inhibition of histone deactylase
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US7101989B1
(en)
|
1999-07-09 |
2006-09-05 |
University Of North Carolina At Chapel Hill |
DsrA protein and polynucleotides encoding the same
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
US20010011126A1
(en)
*
|
1999-09-10 |
2001-08-02 |
Bock Elisabeth Marianne |
Neurogenic compositions and methods
|
US7332275B2
(en)
|
1999-10-13 |
2008-02-19 |
Sequenom, Inc. |
Methods for detecting methylated nucleotides
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
JP2004533850A
(ja)
|
2000-03-24 |
2004-11-11 |
メチルジーン・インコーポレーテッド |
特異的なヒストン脱アセチル化酵素アイソフォームの阻害
|
US20060052319A9
(en)
*
|
2000-04-03 |
2006-03-09 |
Sudhir Agrawal |
Sensitization of cells to cytotoxic agents using oligonucleotides directed to nucleotide excision repair or transcritpion coupled repair genes
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
CA2411139A1
(en)
*
|
2000-06-08 |
2001-12-13 |
James T. Willerson |
Inhibitors of c-reactive protein induced inflammation
|
US6958214B2
(en)
*
|
2000-07-10 |
2005-10-25 |
Sequenom, Inc. |
Polymorphic kinase anchor proteins and nucleic acids encoding the same
|
US6596490B2
(en)
*
|
2000-07-14 |
2003-07-22 |
Applied Gene Technologies, Inc. |
Nucleic acid hairpin probes and uses thereof
|
US6380377B1
(en)
*
|
2000-07-14 |
2002-04-30 |
Applied Gene Technologies, Inc. |
Nucleic acid hairpin probes and uses thereof
|
US20030152557A1
(en)
*
|
2001-01-12 |
2003-08-14 |
Besterman Jeffrey M. |
Methods for inhibiting histone deacetylase-4
|
US20030148970A1
(en)
*
|
2001-01-12 |
2003-08-07 |
Besterman Jeffrey M. |
Methods for specifically inhibiting histone deacetylase-4
|
WO2002059337A1
(en)
*
|
2001-01-26 |
2002-08-01 |
Georgetown University School Of Medicine |
Anti-apoptopic gene scc-s2 and diagnostic and therapeutic uses thereof
|
AU2002305151A1
(en)
*
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene scc-112 and diagnostic and therapeutic uses thereof
|
AU2002303262A1
(en)
*
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene shinc-1 and diagnostic and therapeutic uses thereof
|
WO2002081642A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc-3 and diagnostic and therapeutic uses thereof
|
WO2002081639A2
(en)
*
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc2 and diagnostic and therapeutic uses thereof
|
CA2446606A1
(en)
*
|
2001-05-11 |
2002-11-21 |
Methylgene, Inc. |
Inhibitors of dna methyltransferase isoforms
|
US7803915B2
(en)
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
MXPA03011985A
(es)
|
2001-06-20 |
2004-03-26 |
Genentech Inc |
Composiciones y metodos para el diagnostico y tratamiento de tumores.
|
CA2451643C
(en)
|
2001-06-21 |
2012-11-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
SE0102327D0
(sv)
|
2001-06-28 |
2001-06-28 |
Active Biotech Ab |
A novel engineered superantigen for human therapy
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US20040266718A1
(en)
*
|
2001-08-06 |
2004-12-30 |
Zuomei Li |
Inhibition of specific histone deacetylase isoforms
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
US7868204B2
(en)
*
|
2001-09-14 |
2011-01-11 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
US6897220B2
(en)
*
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
CN1578663B
(zh)
*
|
2001-09-14 |
2011-05-25 |
梅特希尔基因公司 |
组蛋白脱乙酰化酶抑制剂
|
ES2390531T3
(es)
|
2001-09-18 |
2012-11-13 |
Genentech, Inc. |
Composiciones y procedimientos para el diagnósitco y tratamiento de tumor
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
EP1488233A4
(de)
|
2001-10-09 |
2006-06-21 |
Genentech Inc |
Neue saure säugerproteine und diese codierende polynukleotide
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
US7276489B2
(en)
*
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
EP2067472A1
(de)
|
2002-01-02 |
2009-06-10 |
Genentech, Inc. |
Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
|
IL152904A0
(en)
|
2002-01-24 |
2003-06-24 |
Gamida Cell Ltd |
Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
|
EP1465982A4
(de)
*
|
2002-01-25 |
2006-06-07 |
Gamida Cell Ltd |
Verfahren zur expansion von stamm- und vorläuferzellen und damit erhaltene expandierte zellpopulationen
|
US7138512B2
(en)
*
|
2002-04-10 |
2006-11-21 |
Georgetown University |
Gene SHINC-2 and diagnostic and therapeutic uses thereof
|
US7244565B2
(en)
*
|
2002-04-10 |
2007-07-17 |
Georgetown University |
Gene shinc-3 and diagnostic and therapeutic uses thereof
|
NZ535925A
(en)
|
2002-04-16 |
2008-06-30 |
Genentech Inc |
An isolated antibody that binds to a particular polypeptide
|
US7432342B2
(en)
|
2002-05-03 |
2008-10-07 |
Sequenom, Inc. |
Kinase anchor protein muteins, peptides thereof and related documents
|
US20030228317A1
(en)
*
|
2002-05-22 |
2003-12-11 |
Prafulla Gokhale |
Gene BRCC-1 and diagnostic and therapeutic uses thereof
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
WO2003106617A2
(en)
*
|
2002-06-12 |
2003-12-24 |
Tel Aviv Medical Center Research Development Fund |
Oligonucleotides antibodies and kits including same for treating prostate cancer and determining predisposition thereto
|
US20040072770A1
(en)
*
|
2002-07-03 |
2004-04-15 |
Besterman Jeffrey M. |
Methods for specifically inhibiting histone deacetylase-7 and 8
|
US20040009483A1
(en)
*
|
2002-07-12 |
2004-01-15 |
Ilsley Diane D. |
Method of linear mRNA amplification using total RNA
|
WO2004014314A2
(en)
|
2002-08-12 |
2004-02-19 |
David Kirn |
Methods and compositions concerning poxviruses and cancer
|
AU2003263853A1
(en)
*
|
2002-08-16 |
2004-03-03 |
Board Of Regents The University Of Texas System |
Compositions and methods related to flavivirus envelope protein domain iii antigens
|
JP2005538186A
(ja)
*
|
2002-09-13 |
2005-12-15 |
レプリコール インコーポレーティッド |
非配列相補性の抗ウイルス性オリゴヌクレオチド
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
DK1545587T3
(da)
|
2002-09-16 |
2011-05-09 |
Agennix Inc |
Lactoferrinsammensætninger og fremgangsmåder til behandling af diabetiske sår
|
EP1549767A4
(de)
|
2002-09-26 |
2006-06-07 |
Amgen Inc |
Modulation der expression von forkhead-box o1a
|
US20040137472A1
(en)
*
|
2002-09-27 |
2004-07-15 |
Ryszard Kole |
Methods and compositions for modification of splicing of pre-mRNA
|
CA2501265A1
(en)
*
|
2002-10-17 |
2004-04-29 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
US9150605B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
EP1560839A4
(de)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
Chimäre oligomere verbindungen und derenverwendung in der genmodulation
|
EP1578765A4
(de)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
Oligomere verbindungen,die zuckerersatzstoffe enthalten, und zusammensetzung zur verwendung in dergenmodulation
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
EP1569695B1
(de)
|
2002-11-13 |
2013-05-15 |
Genzyme Corporation |
Antisense-modulation von apolipoprotein-b-expression
|
DK2336318T3
(da)
|
2002-11-13 |
2013-07-15 |
Genzyme Corp |
Antisense-modulering af apolipoprotein b-ekspression
|
WO2004046330A2
(en)
|
2002-11-15 |
2004-06-03 |
Morphotek, Inc. |
Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
AU2004206820B2
(en)
*
|
2003-01-16 |
2010-06-10 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
|
US7354907B2
(en)
*
|
2003-02-07 |
2008-04-08 |
Idera Pharmaceuticals, Inc. |
Short immunomodulatory oligonucleotides
|
CA2515484C
(en)
|
2003-02-11 |
2011-09-20 |
Antisense Therapeutics Ltd |
Modulation of insulin like growth factor i receptor expression
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
AU2004220556B2
(en)
|
2003-03-07 |
2009-05-07 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
JP2007524380A
(ja)
|
2003-04-02 |
2007-08-30 |
ボード オブ リージェンツ ザ ユニバーティー オブ テキサス システム |
抗腫瘍効果をもつBik変異型
|
AU2004229519B2
(en)
|
2003-04-09 |
2011-07-21 |
Alnylam Pharmaceuticals, Inc. |
iRNA conjugates
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
EP1625138A4
(de)
|
2003-04-17 |
2010-06-23 |
Alnylam Pharmaceuticals Inc |
Geschützte monomere
|
EP2664672A1
(de)
|
2003-04-17 |
2013-11-20 |
Alnylam Pharmaceuticals Inc. |
Modifizierte iRNA-Wirkstoffe
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
US7569554B2
(en)
*
|
2003-05-16 |
2009-08-04 |
Idera Pharmaceuticals, Inc. |
Synergistic treatment of cancer using immunomers in conjunction with therapeutic agents
|
WO2005002507A2
(en)
|
2003-06-03 |
2005-01-13 |
Isis Pharmaceuticals, Inc. |
Modulation of survivin expression
|
KR101137572B1
(ko)
|
2003-06-11 |
2012-05-30 |
이데라 파마슈티칼즈, 인코포레이티드 |
안정화된 면역조절 올리고뉴클레오티드
|
WO2004113496A2
(en)
*
|
2003-06-20 |
2004-12-29 |
Isis Pharmaceuticals, Inc. |
Double stranded compositions comprising a 3’-endo modified strand for use in gene modulation
|
MXPA06000619A
(es)
|
2003-07-15 |
2006-04-11 |
Hybridon Inc |
Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion.
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
EP2182063A3
(de)
|
2003-09-18 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Modulierung von EIF4E-Expression
|
AU2004274021B2
(en)
|
2003-09-18 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
AU2004276337B2
(en)
*
|
2003-09-24 |
2009-11-12 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
EP1687410A4
(de)
*
|
2003-10-07 |
2008-04-09 |
Isis Pharmaceuticals Inc |
Für das nieren-targeting optimierte antisense-oligonukleotide
|
EP1678194B1
(de)
|
2003-10-10 |
2013-06-26 |
Alchemia Oncology Pty Limited |
Modulation der synthese und des abbaus von hyaluronan bei der behandlung von krankheiten
|
EP2267154A1
(de)
|
2003-10-23 |
2010-12-29 |
Illumigen Biosciences, Inc. |
Oligoadenylate Synthetase
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
JP4901478B2
(ja)
|
2003-11-17 |
2012-03-21 |
ジェネンテック, インコーポレイテッド |
造血系起源の腫瘍の治療のための組成物と方法
|
US20050120397A1
(en)
*
|
2003-11-24 |
2005-06-02 |
Hermann Steller |
Compounds and methods for regulation of spermatid differentiation
|
AU2004304770B2
(en)
*
|
2003-12-08 |
2010-05-06 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties by small oligonucleotide-based compounds
|
US7741070B2
(en)
*
|
2003-12-24 |
2010-06-22 |
Massachusetts Institute Of Technology |
Gene targets for enhanced carotenoid production
|
WO2005062923A2
(en)
*
|
2003-12-24 |
2005-07-14 |
Massachusetts Institute Of Technology |
Gene targets for enhanced carotenoid production
|
US7608699B2
(en)
*
|
2003-12-29 |
2009-10-27 |
Rockefeller University |
Synthetic nuclear localization signal derived from lentiviral integrase and methods of use thereof
|
EP1711606A2
(de)
|
2004-01-20 |
2006-10-18 |
Isis Pharmaceuticals, Inc. |
Modulation der expression des glucocorticoidrezeptors
|
US7468431B2
(en)
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
JP2007523173A
(ja)
*
|
2004-02-20 |
2007-08-16 |
イデラ ファーマシューティカルズ インコーポレイテッド |
修飾免疫調節オリゴヌクレオチドにより誘導された強力な粘膜免疫応答
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
EP2700720A3
(de)
|
2004-03-15 |
2015-01-28 |
Isis Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur Optimierung der Spaltung von RNA durch RNase H
|
US7253204B2
(en)
*
|
2004-03-26 |
2007-08-07 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
WO2005094370A2
(en)
*
|
2004-03-29 |
2005-10-13 |
The General Hospital Corporation |
Oligonucleotide complex compositions and methods of use as gene alteration tools
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
WO2005097817A2
(en)
|
2004-04-05 |
2005-10-20 |
Alnylam Pharmaceuticals, Inc. |
Process and reagents for oligonucleotide synthesis and purification
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US7427405B2
(en)
*
|
2004-06-15 |
2008-09-23 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory oligonucleotide multimers
|
WO2006002038A2
(en)
*
|
2004-06-15 |
2006-01-05 |
Hybridon, Inc. |
Immunostimulatory oligonucleotide multimers
|
US7785843B2
(en)
*
|
2004-06-23 |
2010-08-31 |
Sequenom, Inc. |
Target-specific compomers and methods of use
|
SI2206781T1
(sl)
|
2004-06-28 |
2016-05-31 |
The University Of Western Australia |
Protismiselni oligonukleotidi za induciranje preskakovanja eksona in postopki njihove uporabe
|
USRE48960E1
(en)
|
2004-06-28 |
2022-03-08 |
The University Of Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
US8680062B2
(en)
|
2004-07-06 |
2014-03-25 |
Deliversir Ltd. |
System for delivering therapeutic agents into living cells and cells nuclei
|
EP2990410A1
(de)
|
2004-08-10 |
2016-03-02 |
Alnylam Pharmaceuticals Inc. |
Chemisch modifizierte oligonukleotide
|
DK2997980T3
(en)
|
2004-08-10 |
2018-03-26 |
Kastle Therapeutics Llc |
PROCEDURES FOR MODULATING LIPROPROTEIN AND CHOLESTEROL LEVELS
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
EP1799812A4
(de)
|
2004-09-16 |
2009-09-09 |
Gamida Cell Ltd |
Verfahren zur ex-vivo-expansion von progenitor- und stammzellen durch gemeinsame kultivierung mit mesenchymzellen
|
WO2006034348A2
(en)
|
2004-09-17 |
2006-03-30 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
CA2584614A1
(en)
|
2004-10-20 |
2006-08-24 |
Antisense Therapeutics Ltd |
Antisense modulation of integrin .alpha.4 expression
|
US8003619B2
(en)
*
|
2004-12-09 |
2011-08-23 |
Alnylam Pharmaceuticals, Inc. |
Method of stimulating an immune response and inhibiting expression of a gene using an oligonucleotide
|
CN101175769A
(zh)
|
2005-03-10 |
2008-05-07 |
健泰科生物技术公司 |
用于调控血管完整性的方法和组合物
|
WO2006102760A1
(en)
*
|
2005-04-01 |
2006-10-05 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
WO2006113666A2
(en)
*
|
2005-04-19 |
2006-10-26 |
Massachusetts Institute Of Technology |
Amphiphilic polymers and methods of use thereof
|
WO2007008300A2
(en)
|
2005-05-31 |
2007-01-18 |
ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE |
Triblock copolymers for cytoplasmic delivery of gene-based drugs
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
DK2380584T3
(da)
|
2005-07-01 |
2014-01-20 |
Index Pharmaceuticals Ab |
Immunstimulerende fremgangsmåde
|
SI2179737T1
(sl)
|
2005-07-01 |
2014-02-28 |
Index Pharmaceuticals Ab |
Modulacija reakcije na stereoide
|
US20070026012A1
(en)
|
2005-08-01 |
2007-02-01 |
Cornell Research Foundation, Inc. |
Compositions and methods for monitoring and altering protein folding and solubility
|
US8980246B2
(en)
|
2005-09-07 |
2015-03-17 |
Sillajen Biotherapeutics, Inc. |
Oncolytic vaccinia virus cancer therapy
|
WO2007030668A2
(en)
*
|
2005-09-07 |
2007-03-15 |
Jennerex Biotherapeutics Ulc |
Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses
|
JP2009513629A
(ja)
*
|
2005-10-28 |
2009-04-02 |
インデックス・ファーマシューティカルズ・アクチエボラーグ |
炎症性疾患を予防、処置、および/または緩和する組成物および方法
|
US7470674B2
(en)
*
|
2005-11-07 |
2008-12-30 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
AU2005338035B2
(en)
|
2005-11-07 |
2012-06-07 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
US7776834B2
(en)
*
|
2005-11-07 |
2010-08-17 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
JP2009516710A
(ja)
|
2005-11-21 |
2009-04-23 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
eIF4E−BP2の発現のモジュレート
|
US8846393B2
(en)
|
2005-11-29 |
2014-09-30 |
Gamida-Cell Ltd. |
Methods of improving stem cell homing and engraftment
|
CN101379195B
(zh)
*
|
2005-12-20 |
2012-05-09 |
艾德拉药物股份有限公司 |
含有不同长度回文片段的回文免疫调节性寡核苷酸(imotm)的免疫刺激活性
|
AU2006336242A1
(en)
*
|
2005-12-20 |
2007-07-26 |
Idera Pharmaceuticals, Inc. |
Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications
|
WO2007123579A2
(en)
|
2005-12-28 |
2007-11-01 |
Translational Therapeutics |
Translational dysfunction based therapeutics
|
CN101437933B
(zh)
|
2005-12-28 |
2013-11-06 |
斯克里普斯研究所 |
作为药物靶标的天然反义和非编码的rna转录物
|
PT2161038E
(pt)
|
2006-01-26 |
2014-03-10 |
Isis Pharmaceuticals Inc |
Composições e suas utilizações dirigidas à huntingtina
|
EP2314594B1
(de)
*
|
2006-01-27 |
2014-07-23 |
Isis Pharmaceuticals, Inc. |
6-Modifizierte bicyclische Nukleinsäureanaloga
|
US8129515B2
(en)
|
2006-01-27 |
2012-03-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of microRNAs
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
ES2452820T3
(es)
|
2006-04-07 |
2014-04-02 |
Methylgene, Inc. |
Derivados de benzamida como inhibidores de histona desacetilasa
|
US20090326041A1
(en)
|
2006-05-05 |
2009-12-31 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
DK2066684T3
(da)
|
2006-05-11 |
2012-10-22 |
Isis Pharmaceuticals Inc |
5´-Modificerede bicycliske nukleinsyreanaloge
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
US9506056B2
(en)
|
2006-06-08 |
2016-11-29 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
LT2056845T
(lt)
|
2006-08-08 |
2017-11-27 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5` fosfato oligonukleotidų struktūra ir panaudojimas
|
EP1920775B1
(de)
|
2006-10-10 |
2012-12-19 |
Gunther Prof. Dr. Hartmann |
5' Triphosphat -oligonukleotid induziert eine antivirale Reaktion
|
AU2007294858B2
(en)
|
2006-09-14 |
2011-05-12 |
Medgenics Medical Israel, Ltd |
Long lasting drug formulations
|
US8454948B2
(en)
|
2006-09-14 |
2013-06-04 |
Medgenics Medical Israel Ltd. |
Long lasting drug formulations
|
CA2921063C
(en)
|
2006-09-15 |
2020-01-28 |
Ottawa Hospital Research Institute |
Oncolytic rhabdovirus
|
CA2666968A1
(en)
|
2006-10-20 |
2008-10-30 |
Arizona Board Of Regents For And On Behalf Of Arizona State University |
Modified cyanobacteria
|
DK2343286T3
(en)
|
2006-10-28 |
2015-04-13 |
Methylgene Inc |
Dibenzo [b, f] [1,4] oxazepine derivatives as inhibitors of histone deacetylase
|
US7645578B2
(en)
*
|
2006-10-31 |
2010-01-12 |
Agilent Technologies, Inc. |
Cleavage of RNA at redundant sites
|
EP2573069A3
(de)
|
2006-12-19 |
2013-05-22 |
MethylGene Inc. |
Histondeacetylase-Hemmer und Prodrugs daraus
|
EP1935428A1
(de)
*
|
2006-12-22 |
2008-06-25 |
Antisense Pharma GmbH |
Oligonukleotid-Polymer Konjugate
|
WO2008094945A2
(en)
|
2007-01-29 |
2008-08-07 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
EP2121987B1
(de)
|
2007-02-09 |
2012-06-13 |
Northwestern University |
Partikel zur erkennung intrazellulärer ziele
|
US8030344B2
(en)
*
|
2007-03-13 |
2011-10-04 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
PT2144633E
(pt)
*
|
2007-04-23 |
2014-10-27 |
Deliversir Ltd |
Um sistema para a administração de agentes terapêuticos em células vivas e núcleos de células
|
US9156865B2
(en)
|
2007-04-23 |
2015-10-13 |
Deliversir Ltd |
System for delivering therapeutic agents into living cells and cells nuclei
|
US9556210B2
(en)
|
2007-04-23 |
2017-01-31 |
Sabag-Rfa Ltd. |
System for delivering therapeutic agents into living cells and cells nuclei
|
AU2008260277C1
(en)
|
2007-05-30 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
ES2376507T5
(es)
*
|
2007-07-05 |
2015-08-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos 6-disustituidos
|
EP2188298B1
(de)
|
2007-08-15 |
2013-09-18 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyrannukleinsäureanaloga
|
WO2009039442A1
(en)
|
2007-09-21 |
2009-03-26 |
California Institute Of Technology |
Nfia in glial fate determination, glioma therapy and astrocytoma treatment
|
CA2700953A1
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
US20100280098A1
(en)
*
|
2007-10-05 |
2010-11-04 |
Juliano Rudolph L |
Receptor targeted oligonucleotides
|
WO2009064920A2
(en)
|
2007-11-13 |
2009-05-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
EP2222851B1
(de)
|
2007-11-20 |
2017-06-28 |
Ionis Pharmaceuticals, Inc. |
Modulation der cd40-expression
|
WO2009067647A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
US8426378B2
(en)
*
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
DK2285819T3
(da)
*
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
EP2274423A2
(de)
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Bicyclische nukleoside umfassende oligomere verbindungen mit verringerter toxizität
|
CA2721183C
(en)
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
EP2297323A1
(de)
|
2008-05-21 |
2011-03-23 |
Hartmann, Gunther |
5 -triphosphat-oligonukleotid mit stumpfem ende und verwendugen davon
|
WO2010017248A2
(en)
|
2008-08-04 |
2010-02-11 |
University Of Miami |
Sting (stimulator of interferon genes), a regulator of innate immune responses
|
EP3081648A1
(de)
|
2008-08-25 |
2016-10-19 |
Excaliard Pharmaceuticals, Inc. |
Gegen den bindegewebe-wachstumsfaktor gerichtete antisense-oligonukleotide und verwendungen davon
|
WO2011028218A1
(en)
|
2009-09-02 |
2011-03-10 |
Alnylam Pharmaceuticals, Inc. |
Process for triphosphate oligonucleotide synthesis
|
JP2012513953A
(ja)
|
2008-09-23 |
2012-06-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
|
US8501805B2
(en)
*
|
2008-09-24 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-L-bicyclic nucleosides
|
EP2361256B1
(de)
*
|
2008-09-24 |
2013-04-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenylverbindungen als nukleinsäureanaloga
|
AU2009305636A1
(en)
|
2008-10-15 |
2010-04-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of Factor 11 expression
|
AU2009308217B2
(en)
|
2008-10-24 |
2016-01-21 |
Ionis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
EP2447274B1
(de)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomerverbindungen und Verfahren
|
WO2010048586A1
(en)
|
2008-10-24 |
2010-04-29 |
Avi Biopharma, Inc. |
Multiple exon skipping compositions for dmd
|
KR20220150995A
(ko)
|
2008-11-10 |
2022-11-11 |
알닐람 파마슈티칼스 인코포레이티드 |
치료제 운반용 신규 지질 및 조성물
|
DK2365803T3
(en)
|
2008-11-24 |
2018-01-22 |
Univ Northwestern |
POLYVALENT RNA NANOPARTICLE COMPOSITIONS
|
ES2637063T3
(es)
|
2008-12-04 |
2017-10-10 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con genes supresores de tumor mediante inhibición del transcrito antisentido natural al gen
|
WO2010065792A2
(en)
|
2008-12-04 |
2010-06-10 |
Curna, Inc. |
Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
|
MX366774B
(es)
|
2008-12-04 |
2019-07-24 |
Curna Inc |
Uso de oligonucleótidos antisentido en la inhibición de transcrito antisentido natural para sirtuina 1.
|
CA2746508A1
(en)
|
2008-12-17 |
2010-07-15 |
Avi Biopharma, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
KR101546673B1
(ko)
*
|
2009-01-15 |
2015-08-25 |
삼성전자주식회사 |
전자 사진용 토너 및 그의 제조방법
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
EP2393825A2
(de)
|
2009-02-06 |
2011-12-14 |
Isis Pharmaceuticals, Inc. |
Oligomere verbindungen und verfahren
|
PL2396038T3
(pl)
|
2009-02-12 |
2016-05-31 |
Curna Inc |
Leczenie chorób związanych z neurotropowym czynnikiem pochodzenia mózgowego (bdnf) poprzez zahamowanie naturalnego antysensownego transkryptu bdnf
|
US20110319476A1
(en)
|
2009-02-12 |
2011-12-29 |
Opko Curna, Llc |
Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
|
US8975389B2
(en)
|
2009-03-02 |
2015-03-10 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
EP2403946A4
(de)
|
2009-03-04 |
2012-11-14 |
|
Behandlung von sirtuin 1 (sirt1)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen sirt 1
|
US9464287B2
(en)
|
2009-03-16 |
2016-10-11 |
Curna, Inc. |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2
|
CA2755404C
(en)
|
2009-03-17 |
2020-03-24 |
Joseph Collard |
Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
|
EP3248618A1
(de)
|
2009-04-22 |
2017-11-29 |
Massachusetts Institute Of Technology |
Angeborene immununterdrückung mit ermöglichung der wiederholten verabreichung von langen rna-molekülen
|
US8318690B2
(en)
|
2009-05-01 |
2012-11-27 |
Curna, Inc. |
Treatment of hemoglobin (HBF/HBG) related diseases by inhibition of natural antisense transcript to HBF/HBG
|
CN106237345A
(zh)
|
2009-05-06 |
2016-12-21 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
ES2609655T3
(es)
|
2009-05-06 |
2017-04-21 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP
|
JP5922017B2
(ja)
|
2009-05-18 |
2016-05-24 |
クルナ・インコーポレーテッド |
リプログラミング因子に対する天然アンチセンス転写物の抑制によるリプログラミング因子関連疾患の治療
|
WO2010135695A2
(en)
|
2009-05-22 |
2010-11-25 |
Curna, Inc. |
TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
|
EP2435571B1
(de)
|
2009-05-28 |
2016-12-14 |
CuRNA, Inc. |
Behandlung von durch antivirale gene bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein antivirales gen
|
CN104873464B
(zh)
|
2009-06-10 |
2018-06-22 |
阿布特斯生物制药公司 |
改进的脂质制剂
|
ES2629339T3
(es)
|
2009-06-16 |
2017-08-08 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la paraoxonasa 1 (pon1) por inhibición de transcrito antisentido natural a pon1
|
KR101801404B1
(ko)
|
2009-06-16 |
2017-12-20 |
큐알엔에이, 인크. |
콜라겐 유전자에 대한 천연 안티센스 전사체의 억제에 의한 콜라겐 유전자 관련된 질환의 치료
|
CA2765889A1
(en)
|
2009-06-24 |
2010-12-29 |
Opko Curna, Llc |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
KR101807324B1
(ko)
|
2009-06-26 |
2017-12-08 |
큐알엔에이, 인크. |
다운 증후군 유전자에 대한 천연 안티센스 전사체의 억제에 의한 다운 증후군 유전자 관련된 질환의 치료
|
CA2769665A1
(en)
|
2009-08-05 |
2011-02-10 |
Opko Curna, Llc |
Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
|
EP2462153B1
(de)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexosenukleinsäureanaloga
|
KR101892760B1
(ko)
|
2009-08-25 |
2018-08-28 |
큐알엔에이, 인크. |
IQGAP에 대한 천연 안티센스 전사체의 억제에 의한 GTPase 활성화 단백질을 함유하는 IQ 모티프(IQGAP)와 관련된 질환의 치료
|
ES2538347T3
(es)
|
2009-08-27 |
2015-06-19 |
Idera Pharmaceuticals, Inc. |
Composiciones para inhibir expresión genética y usos de las mismas
|
DK2473522T3
(en)
|
2009-09-02 |
2016-11-28 |
Genentech Inc |
Smoothened MUTANT AND METHODS OF USING THE SAME
|
EP3409119B1
(de)
|
2009-09-14 |
2020-08-12 |
SillaJen Biotherapeutics, Inc. |
Krebskombinationstherapie mit onkolytischem vaccinia virus
|
RU2539772C2
(ru)
|
2009-10-22 |
2015-01-27 |
Дженентек, Инк. |
Способы и композиции для модуляции гепсином стимулирующего макрофаги белка
|
AU2010313154B2
(en)
|
2009-10-30 |
2016-05-12 |
Northwestern University |
Templated nanoconjugates
|
KR102487132B1
(ko)
|
2009-11-12 |
2023-01-10 |
더 유니버시티 오브 웨스턴 오스트레일리아 |
안티센스 분자 및 이를 이용한 질환 치료방법
|
CN102712928B
(zh)
|
2009-11-13 |
2017-08-04 |
萨雷普塔治疗公司 |
反义抗病毒化合物及治疗流感病毒感染的方法
|
PE20121584A1
(es)
|
2009-11-30 |
2012-11-29 |
Genentech Inc |
Composiciones y metodos para el diagnostico y el tratamiento de tumores
|
CA3044884A1
(en)
|
2009-12-07 |
2011-06-16 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
MX337062B
(es)
|
2009-12-10 |
2016-02-11 |
Ottawa Hospital Res Inst |
Rabdovirus oncolítico.
|
ES2661813T3
(es)
|
2009-12-16 |
2018-04-04 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la peptidasa del factor de transcripción de membrana, sitio 1 (mbtps1) mediante inhibición del transcrito antisentido natural al gen mbtps1
|
US20130017223A1
(en)
|
2009-12-18 |
2013-01-17 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
EP2515947B1
(de)
|
2009-12-23 |
2021-10-06 |
CuRNA, Inc. |
Behandlung von durch das uncoupling protein 2 (ucp2) bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts für ucp2
|
WO2011079261A2
(en)
|
2009-12-23 |
2011-06-30 |
Curna, Inc. |
Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf
|
RU2615450C2
(ru)
|
2009-12-29 |
2017-04-04 |
Курна, Инк. |
Лечение заболеваний, связанных с ядерным респираторным фактором 1(nrf1), путем ингибирования природного антисмыслового транскрипта к nrf1
|
JP5982288B2
(ja)
|
2009-12-29 |
2016-08-31 |
カッパーアールエヌエー,インコーポレイテッド |
腫瘍タンパク質63(p63)に対する天然アンチセンス転写物の阻害による腫瘍タンパク質63関連疾患の治療
|
DK2521784T3
(en)
|
2010-01-04 |
2018-03-12 |
Curna Inc |
TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
|
JP5963680B2
(ja)
|
2010-01-06 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011085347A2
(en)
|
2010-01-11 |
2011-07-14 |
Opko Curna, Llc |
Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
|
ES2671877T3
(es)
|
2010-01-25 |
2018-06-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
CN102844435B
(zh)
|
2010-02-22 |
2017-05-10 |
库尔纳公司 |
通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
KR20130004579A
(ko)
|
2010-02-23 |
2013-01-11 |
제넨테크, 인크. |
종양의 진단 및 치료를 위한 조성물 및 방법
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
US9068185B2
(en)
|
2010-03-12 |
2015-06-30 |
Sarepta Therapeutics, Inc. |
Antisense modulation of nuclear hormone receptors
|
EP2544703A4
(de)
|
2010-03-12 |
2013-09-18 |
Brigham & Womens Hospital |
Verfahren zur behandlung von gefässentzündungserkrankungen
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
EP2556160A4
(de)
|
2010-04-09 |
2013-08-21 |
Curna Inc |
Behandlung von erkrankungen im zusammenhang mit dem fibroblastenwachstumsfaktor 21 (fgf21) mittels hemmung des natürlichen antisense-transkripts gegen fgf21
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
WO2011139714A2
(en)
|
2010-04-26 |
2011-11-10 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
|
CN103096911B
(zh)
|
2010-04-27 |
2018-05-29 |
Atyr 医药公司 |
与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
US9156873B2
(en)
|
2010-04-28 |
2015-10-13 |
Isis Pharmaceuticals, Inc. |
Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
|
EP2625186B1
(de)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
WO2011139853A2
(en)
|
2010-04-28 |
2011-11-10 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
|
WO2011150279A2
(en)
|
2010-05-27 |
2011-12-01 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
|
AU2011248457B2
(en)
|
2010-04-29 |
2017-02-16 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
|
ES2625689T3
(es)
|
2010-04-29 |
2017-07-20 |
Ionis Pharmaceuticals, Inc. |
Modulación de la expresión de transtiretina
|
CN103097523B
(zh)
|
2010-04-29 |
2016-09-28 |
Atyr医药公司 |
与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
CN107090045A
(zh)
|
2010-05-03 |
2017-08-25 |
霍夫曼-拉罗奇有限公司 |
用于肿瘤诊断和治疗的组合物和方法
|
CN105820252B
(zh)
|
2010-05-03 |
2020-07-21 |
Atyr 医药公司 |
与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
WO2011139387A1
(en)
|
2010-05-03 |
2011-11-10 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
US8961961B2
(en)
|
2010-05-03 |
2015-02-24 |
a Tyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
|
US8981045B2
(en)
|
2010-05-03 |
2015-03-17 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
|
CA2798139C
(en)
|
2010-05-04 |
2019-09-24 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
|
US9457079B2
(en)
|
2010-05-12 |
2016-10-04 |
The Trustees Of Columbia University In The City Of New York |
Methods for producing enteroendocrine cells that make and secrete insulin
|
ES2816898T3
(es)
|
2010-05-13 |
2021-04-06 |
Sarepta Therapeutics Inc |
Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23
|
CN103200953B
(zh)
|
2010-05-14 |
2017-02-15 |
Atyr 医药公司 |
与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
AU2011256366C1
(en)
|
2010-05-17 |
2017-06-15 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
|
KR20180053419A
(ko)
|
2010-05-26 |
2018-05-21 |
큐알엔에이, 인크. |
무조(無調)의 동소체 1 (atoh1)에 대한 자연 안티센스 전사체의 저해에 의한 atoh1 관련된 질환의 치료
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
JP2013532152A
(ja)
|
2010-06-15 |
2013-08-15 |
メドジェニクス・メディカル・イスラエル・リミテッド |
長期持続性の医薬製剤
|
AU2011289831C1
(en)
|
2010-07-12 |
2017-06-15 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
|
WO2012009402A2
(en)
|
2010-07-14 |
2012-01-19 |
Opko Curna Llc |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
CN103108650A
(zh)
|
2010-08-25 |
2013-05-15 |
Atyr医药公司 |
与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
EP3118316A1
(de)
|
2010-09-02 |
2017-01-18 |
Université de Mons |
Zur behandlung von fazioskapulohumeraler muskeldystrophie nützliche wirkstoffe
|
AU2011312205B2
(en)
|
2010-10-05 |
2015-08-13 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
CA2813901C
(en)
|
2010-10-06 |
2019-11-12 |
Curna, Inc. |
Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
|
US20140031250A1
(en)
|
2010-10-07 |
2014-01-30 |
David Tsai Ting |
Biomarkers of Cancer
|
EP2630241B1
(de)
|
2010-10-22 |
2018-10-17 |
CuRNA, Inc. |
Behandlung von alpha-l-iduronidase (idua)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen idua
|
ES2677070T3
(es)
|
2010-10-27 |
2018-07-27 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el regulador del desarrollo 1 asociado a interferón (ifrd1) mediante inhibición del transcrito antisentido natural al gen ifrd1
|
EP2638163B1
(de)
|
2010-11-12 |
2017-05-17 |
The General Hospital Corporation |
Polycomb-assoziierte nicht-kodierende rnas
|
EP2640853B1
(de)
|
2010-11-17 |
2018-12-26 |
Ionis Pharmaceuticals, Inc. |
Modulation von alpha-synukleinexpression
|
ES2657590T3
(es)
|
2010-11-23 |
2018-03-06 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con nanog mediante inhibición del transcrito antisentido natural a nanog
|
WO2012094386A1
(en)
|
2011-01-04 |
2012-07-12 |
Jennerex Inc. |
Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
|
WO2012099755A1
(en)
|
2011-01-11 |
2012-07-26 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
US9045749B2
(en)
|
2011-01-14 |
2015-06-02 |
The General Hospital Corporation |
Methods targeting miR-128 for regulating cholesterol/lipid metabolism
|
WO2012101601A1
(en)
|
2011-01-27 |
2012-08-02 |
Ramot At Tel-Aviv University Ltd. |
Glycogen synthase kinase-3 inhibitors
|
WO2012101599A2
(en)
|
2011-01-27 |
2012-08-02 |
Ramot At Tel-Aviv University Ltd. |
Glycogen synthase kinase-3 inhibitors
|
TWI593416B
(zh)
|
2011-02-02 |
2017-08-01 |
艾克厘德製藥公司 |
利用針對結締組織生長因子(ctgf)目標之反義化合物治療瘢痕或肥厚性疤痕之方法
|
US20130338178A1
(en)
|
2011-02-02 |
2013-12-19 |
The Trustees Of Princeton University |
Sirtuin modulators as inhibitors of cytomegalovirus
|
US8877722B2
(en)
|
2011-03-25 |
2014-11-04 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting gene expression and uses thereof
|
EP2508530A1
(de)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
|
WO2012138223A2
(en)
|
2011-04-05 |
2012-10-11 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Compounds and methods for altering activin receptor-like kinase signalling
|
ES2627529T3
(es)
|
2011-06-08 |
2017-07-28 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Composiciones para tratamiento de glioblastoma
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
RU2620980C2
(ru)
|
2011-06-09 |
2017-05-30 |
Курна, Инк. |
Лечение заболеваний, связанных с фратаксином (fxn), путем ингибирования природного антисмыслового транскрипта fxn
|
US20140227293A1
(en)
|
2011-06-30 |
2014-08-14 |
Trustees Of Boston University |
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
EP3640332A1
(de)
|
2011-08-29 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Oligomer-konjugat-komplexe und deren verwendung
|
CA2847698C
(en)
|
2011-09-14 |
2020-09-01 |
Northwestern University |
Nanoconjugates able to cross the blood-brain barrier
|
JP6129844B2
(ja)
|
2011-09-14 |
2017-05-17 |
ラナ セラピューティクス インコーポレイテッド |
多量体オリゴヌクレオチド化合物
|
WO2013043720A1
(en)
|
2011-09-20 |
2013-03-28 |
The University Of North Carolina At Chapel Hill |
Regulation of sodium channels by plunc proteins
|
WO2013049328A1
(en)
|
2011-09-27 |
2013-04-04 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
BR112014008925A2
(pt)
|
2011-10-11 |
2020-10-27 |
The Brigham And Women's Hospital, Inc. |
micro rnas em distúrbios de neurodegenerativos
|
EP2596806A1
(de)
|
2011-11-25 |
2013-05-29 |
Index Pharmaceuticals AB |
Verfahren zur Vorbeugung einer Dickdarmresektion
|
DK2790736T3
(en)
|
2011-12-12 |
2018-05-07 |
Oncoimmunin Inc |
In vivo delivery of oligonucleotides
|
CA2863795A1
(en)
|
2012-02-13 |
2013-08-22 |
Gamida-Cell Ltd. |
Culturing of mesenchymal stem cells
|
CA2866819C
(en)
|
2012-03-13 |
2022-01-04 |
James Cook University |
Method for treating inflammation
|
EP2639238A1
(de)
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclische Nukleoside und daraus hergestellte oligomere Verbindungen
|
US20150031750A1
(en)
|
2012-03-15 |
2015-01-29 |
The Scripps Research Institute |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
US9610362B2
(en)
|
2012-03-16 |
2017-04-04 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of DMPK
|
EP2831231A1
(de)
|
2012-03-30 |
2015-02-04 |
Isis Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur modulation der tau-expression zur verringerung von anfällen und modifizierung eines neurodegenerativen syndroms
|
EP2850092B1
(de)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclische nukleinsäureanaloga
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
CN104704122A
(zh)
|
2012-04-20 |
2015-06-10 |
艾珀特玛治疗公司 |
产热的miRNA调节剂
|
CA2873809A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
US10059941B2
(en)
|
2012-05-16 |
2018-08-28 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
WO2013184209A1
(en)
|
2012-06-04 |
2013-12-12 |
Ludwig Institute For Cancer Research Ltd. |
Mif for use in methods of treating subjects with a neurodegenerative disorder
|
US9567569B2
(en)
|
2012-07-23 |
2017-02-14 |
Gamida Cell Ltd. |
Methods of culturing and expanding mesenchymal stem cells
|
US9175266B2
(en)
|
2012-07-23 |
2015-11-03 |
Gamida Cell Ltd. |
Enhancement of natural killer (NK) cell proliferation and activity
|
US20150216892A1
(en)
|
2012-08-03 |
2015-08-06 |
Aptamir Therapeutics, Inc. |
Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
|
EP2885312A4
(de)
|
2012-08-15 |
2016-01-20 |
Isis Pharmaceuticals Inc |
Verfahren zur herstellung oligomerer verbindungen unter verwendung von modifizierten kappungsprotokollen
|
LT3421602T
(lt)
|
2012-09-06 |
2021-05-25 |
The University Of Chicago |
Priešprasmiai polinukleotidai, skirti indukuoti egzono praleidimą ir distrofijų gydymo būdai
|
EP2712870A1
(de)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
|
CN111621507A
(zh)
|
2012-09-28 |
2020-09-04 |
北卡罗来纳-查佩尔山大学 |
靶向少突胶质细胞的aav载体
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
AU2013336237A1
(en)
|
2012-10-22 |
2015-06-11 |
Sabag-Rfa Ltd |
A system for delivering therapeutic agents into living cells and cells nuclei
|
AU2013364158A1
(en)
|
2012-12-20 |
2015-07-09 |
Sarepta Therapeutics, Inc. |
Improved exon skipping compositions for treating muscular dystrophy
|
CN105658790A
(zh)
|
2013-02-21 |
2016-06-08 |
东安大略研究所儿童医院有限公司 |
疫苗组合物
|
BR122020016865B1
(pt)
|
2013-03-14 |
2022-12-27 |
Sarepta Therapeutics, Inc. |
Oligonucleotídeo antisenso, composição farmacêutica compreendendo o mesmo e uso da dita composição para o tratamento de distrofia muscular de duchenne (dmd)
|
PL2970964T3
(pl)
|
2013-03-14 |
2019-06-28 |
Sarepta Therapeutics, Inc. |
Kompozycje pomijające eksony do leczenia dystrofii mięśniowej
|
EP2971142B1
(de)
|
2013-03-14 |
2020-06-24 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur modulation der tau-genexpression
|
CA2906812A1
(en)
|
2013-03-15 |
2014-09-18 |
Sarepta Therapeutics, Inc. |
Improved compositions for treating muscular dystrophy
|
CA2918194C
(en)
|
2013-03-27 |
2022-12-06 |
The General Hospital Corporation |
Methods and agents for treating alzheimer's disease
|
EA031393B1
(ru)
|
2013-05-01 |
2018-12-28 |
Ионис Фармасьютикалз, Инк. |
Композиции и способы модулирования экспрессии hbv и ttr
|
US20160129089A1
(en)
|
2013-06-13 |
2016-05-12 |
Antisense Therapeutics Ltd |
Combination therapy
|
EP3013850B1
(de)
|
2013-06-24 |
2018-07-25 |
Ramot at Tel-Aviv University Ltd. |
Glycogensynthasekinase-3-inhibitoren
|
TWI657819B
(zh)
|
2013-07-19 |
2019-05-01 |
美商Ionis製藥公司 |
用於調節τ蛋白表現之組合物
|
JP2016536343A
(ja)
|
2013-09-18 |
2016-11-24 |
ジェームス・クック・ユニバーシティー |
抗炎症性のタンパク質及び使用方法
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
CA2931829A1
(en)
|
2013-12-02 |
2015-06-11 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
EP2883883A1
(de)
|
2013-12-16 |
2015-06-17 |
Cardio3 Biosciences S.A. |
Therapeutische Ziele und Mittel zur Behandlung von ischämiebedingten Reperfusionsschäden
|
US9636298B2
(en)
|
2014-01-17 |
2017-05-02 |
Methylgene Inc. |
Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
|
PT3099333T
(pt)
|
2014-01-31 |
2020-12-24 |
Univ Temple |
Bag3 como alvo para terapia de insuficiência cardíaca
|
CA2937539A1
(en)
|
2014-02-04 |
2015-08-13 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
WO2015142910A1
(en)
|
2014-03-17 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
AU2015231130C1
(en)
|
2014-03-19 |
2021-12-23 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating Ataxin 2 expression
|
US10006027B2
(en)
|
2014-03-19 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating Ataxin 2 expression
|
AU2015240761B2
(en)
|
2014-04-01 |
2019-09-12 |
Biogen Ma Inc. |
Compositions for modulating SOD-1 expression
|
US10221416B2
(en)
|
2014-04-24 |
2019-03-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
EP3647318B1
(de)
|
2014-04-28 |
2021-06-30 |
Ionis Pharmaceuticals, Inc. |
Verbindungsmodifizierte oligomerverbindungen
|
BR112016022593B1
(pt)
|
2014-05-01 |
2022-04-26 |
Ionis Pharmaceuticals, Inc |
Compostos oligoméricos, composições que os compreendem, e usos dos mesmos
|
CA2946003A1
(en)
|
2014-05-01 |
2015-11-05 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating angiopoietin-like 3 expression
|
ES2812099T3
(es)
|
2014-05-01 |
2021-03-16 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento
|
AU2015269412B2
(en)
|
2014-06-04 |
2020-03-12 |
Exicure Operating Company |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
HRP20220379T1
(hr)
|
2014-06-10 |
2022-05-27 |
Erasmus University Medical Center Rotterdam |
Antisense oligonukleotidi korisni u liječenju pompeove bolesti
|
EP3161159B1
(de)
|
2014-06-25 |
2020-08-05 |
The General Hospital Corporation |
Targeting von humanem satellit ii (hsatii)
|
US10487314B2
(en)
|
2014-06-26 |
2019-11-26 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
WO2016044271A2
(en)
|
2014-09-15 |
2016-03-24 |
Children's Medical Center Corporation |
Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
|
EP3198012B1
(de)
|
2014-09-26 |
2019-09-04 |
University of Massachusetts |
Rna-modulierende stoffe
|
CN115040532A
(zh)
|
2014-10-10 |
2022-09-13 |
伊黛拉制药有限公司 |
使用tlr9激动剂与检查点抑制剂对癌症的治疗
|
US20170304459A1
(en)
|
2014-10-10 |
2017-10-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
MX2017006652A
(es)
|
2014-11-21 |
2017-08-21 |
Univ North Carolina Chapel Hill |
Vectores de virus adeno-asociado (aav) dirigidos al sistema nervioso central.
|
WO2016081911A2
(en)
|
2014-11-21 |
2016-05-26 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
AU2016215124B2
(en)
|
2015-02-06 |
2020-08-06 |
The University Of North Carolina At Chapel Hill |
Optimized human clotting Factor VIII gene expression cassettes and their use
|
EP3256487A4
(de)
|
2015-02-09 |
2018-07-18 |
Duke University |
Zusammensetzungen und verfahren zur epigenombearbeitung
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
US10961532B2
(en)
|
2015-04-07 |
2021-03-30 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive X chromosome
|
DK3283500T3
(en)
|
2015-04-08 |
2020-11-16 |
Univ Chicago |
Compositions and methods for correcting limb girdle muscular dystrophy type 2C using exon skipping
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
AU2016259971B2
(en)
|
2015-05-11 |
2021-12-09 |
ProGenis Pty Ltd |
Multiple sclerosis treatment
|
WO2016210241A1
(en)
|
2015-06-26 |
2016-12-29 |
Beth Israel Deaconess Medical Center, Inc. |
Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
|
US10590425B2
(en)
|
2015-06-29 |
2020-03-17 |
Caris Science, Inc. |
Therapeutic oligonucleotides
|
AU2016298317B2
(en)
|
2015-07-28 |
2021-02-18 |
Caris Science, Inc. |
Targeted oligonucleotides
|
US10533175B2
(en)
|
2015-09-25 |
2020-01-14 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Ataxin 3 expression
|
ES2938883T3
(es)
|
2015-11-05 |
2023-04-17 |
Los Angeles Childrens Hospital |
Oligo antisentido para su uso en el tratamiento de la leucemia mieloide aguda
|
WO2017079739A1
(en)
|
2015-11-06 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
MODULATING APOLIPOPROTEIN (a) EXPRESSION
|
CA3005878A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
US11058709B1
(en)
|
2015-12-04 |
2021-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
AU2015416656B2
(en)
|
2015-12-07 |
2023-02-23 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for Pompe disease
|
JOP20200228A1
(ar)
|
2015-12-21 |
2017-06-16 |
Novartis Ag |
تركيبات وطرق لخفض تعبير البروتين tau
|
AU2017205462A1
(en)
|
2016-01-05 |
2018-06-07 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing LRRK2 expression
|
EA201891601A1
(ru)
|
2016-01-10 |
2019-03-29 |
Неоткс Терапьютикс Лтд. |
Способы и композиции, усиливающие эффективность опосредованной суперантигеном иммунотерапии злокачественных опухолей
|
CN109071625A
(zh)
|
2016-02-04 |
2018-12-21 |
柯瑞斯公司 |
平滑化突变体和其使用方法
|
EP3419665A4
(de)
|
2016-02-25 |
2019-10-16 |
The Brigham and Women's Hospital, Inc. |
Behandlungsverfahren für fibrose-targeting-smoc2
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
US10577607B2
(en)
|
2016-03-16 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Modulation of DYRK1B expression
|
JP2019516393A
(ja)
|
2016-03-18 |
2019-06-20 |
カリス サイエンス インコーポレイテッド |
オリゴヌクレオチドプローブおよびその使用
|
AU2017271579B2
(en)
|
2016-05-25 |
2023-10-19 |
Caris Science, Inc. |
Oligonucleotide probes and uses thereof
|
US11236339B2
(en)
|
2016-06-17 |
2022-02-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of GYS1 expression
|
AU2017296195A1
(en)
|
2016-07-11 |
2019-01-24 |
Translate Bio Ma, Inc. |
Nucleic acid conjugates and uses thereof
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
KR20190065341A
(ko)
|
2016-10-06 |
2019-06-11 |
아이오니스 파마수티컬즈, 인코포레이티드 |
올리고머 화합물들의 접합 방법
|
CA3037046A1
(en)
|
2016-10-31 |
2018-05-03 |
University Of Massachusetts |
Targeting microrna-101-3p in cancer therapy
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
EP3548620A4
(de)
|
2016-12-02 |
2020-07-22 |
Cold Spring Harbor Laboratory |
Modulation der lnc05-expression
|
WO2018141027A1
(en)
|
2017-02-03 |
2018-08-09 |
The University Of Western Australia |
Novel treatment for neat1 associated disease
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
US20200033347A1
(en)
|
2017-04-18 |
2020-01-30 |
Universite Libre De Bruxelles |
Biomarkers And Targets For Proliferative Diseases
|
WO2018195338A1
(en)
|
2017-04-20 |
2018-10-25 |
Atyr Pharma, Inc. |
Compositions and methods for treating lung inflammation
|
US20200384115A1
(en)
|
2017-04-21 |
2020-12-10 |
The Broad Institute , Inc. |
Targeted delivery to beta cells
|
GB201707501D0
(en)
|
2017-05-10 |
2017-06-21 |
Index Pharmaceuticals Ab |
New therapy 2
|
GB201707503D0
(en)
|
2017-05-10 |
2017-06-21 |
Index Pharmaceuticals Ab |
New Therapy 3
|
EP3665304A4
(de)
|
2017-08-11 |
2021-04-28 |
Agency for Science, Technology and Research |
Verfahren zum screening von spleissvarianten oder ereignissen
|
US11197884B2
(en)
|
2017-08-18 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
US11597932B2
(en)
|
2017-12-21 |
2023-03-07 |
Alnylam Pharmaceuticals, Inc. |
Chirally-enriched double-stranded RNA agents
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
CN111902537A
(zh)
|
2018-01-15 |
2020-11-06 |
Ionis制药公司 |
Dnm2表达的调节剂
|
BR112020016001A2
(pt)
|
2018-03-02 |
2020-12-15 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão irf4
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
WO2019183440A1
(en)
|
2018-03-22 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
CA3095545A1
(en)
|
2018-03-30 |
2019-10-03 |
Rheinische Friedrich-Wilhelms-Universitat Bonn |
Aptamers for targeted activaton of t cell-mediated immunity
|
CA3096274A1
(en)
|
2018-04-06 |
2019-10-10 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
CN112041440A
(zh)
|
2018-04-11 |
2020-12-04 |
Ionis制药公司 |
Ezh2表达的调节剂
|
GB201807312D0
(en)
|
2018-05-03 |
2018-06-20 |
Index Pharmaceuticals Ab |
Formulation
|
SG11202010215TA
(en)
|
2018-05-09 |
2020-11-27 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn3 expression
|
CU20200082A7
(es)
|
2018-05-09 |
2021-06-08 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para la reducción de la expresión de fxi
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
WO2020006267A1
(en)
|
2018-06-27 |
2020-01-02 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing lrrk2 expression
|
WO2020010059A1
(en)
|
2018-07-02 |
2020-01-09 |
Aptamir Therapeutics, Inc. |
Targeted delivery of therapeutic agents to human adipocytes
|
AR115847A1
(es)
|
2018-07-25 |
2021-03-03 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para reducir la expresión de la atxn2
|
EP3843845A4
(de)
|
2018-08-29 |
2022-05-11 |
University Of Massachusetts |
Hemmung von proteinkinasen zur behandlung von friedreich-ataxie
|
WO2020048607A1
(en)
|
2018-09-07 |
2020-03-12 |
Université Libre de Bruxelles |
Srsf2 as rna epigenetic factor
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
GB201818579D0
(en)
|
2018-11-14 |
2018-12-26 |
Index Pharmaceuticals Ab |
New therapy
|
AU2019380940A1
(en)
|
2018-11-15 |
2021-06-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of IRF5 expression
|
KR20210122809A
(ko)
|
2019-01-31 |
2021-10-12 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Yap1 발현의 조절인자
|
WO2020171889A1
(en)
|
2019-02-19 |
2020-08-27 |
University Of Rochester |
Blocking lipid accumulation or inflammation in thyroid eye disease
|
BR112021015323A2
(pt)
|
2019-02-27 |
2021-10-05 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de malat1
|
WO2020205463A1
(en)
|
2019-03-29 |
2020-10-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating ube3a-ats
|
KR20220009971A
(ko)
|
2019-05-14 |
2022-01-25 |
모나쉬 유니버시티 |
최종당화산물 수용체 알엔에이의 조절인자 및 조절
|
MX2021013908A
(es)
|
2019-05-15 |
2022-03-11 |
Neotx Therapeutics Ltd |
Tratamiento para el cáncer.
|
EP3956450A4
(de)
|
2019-07-26 |
2022-11-16 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation von gfap
|
EP4013767A4
(de)
|
2019-08-15 |
2023-10-25 |
Ionis Pharmaceuticals, Inc. |
Verbindungsmodifizierte oligomere verbindungen und ihre verwendungen
|
GB201912191D0
(en)
|
2019-08-24 |
2019-10-09 |
Index Pharmaceuticals Ab |
New therapy
|
WO2021069543A1
(en)
|
2019-10-08 |
2021-04-15 |
Luxembourg Institute Of Health (Lih) |
Inhibitor of dj-1 for use in treating immunoaging
|
SG10201914033YA
(en)
|
2019-12-31 |
2021-07-29 |
Wilmar International Ltd |
Polypeptides with Lipase Activity and Uses Thereof
|
CR20220485A
(es)
|
2020-02-28 |
2022-11-10 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
CA3170369A1
(en)
|
2020-03-05 |
2022-04-14 |
Michal Shahar |
Methods and compositions for treating cancer with immune cells
|
TW202206596A
(zh)
|
2020-05-01 |
2022-02-16 |
美商Ionis製藥公司 |
調節atxn1之化合物及方法
|
BR112022024206A2
(pt)
|
2020-06-29 |
2023-01-03 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para modular plp1
|
US11447521B2
(en)
|
2020-11-18 |
2022-09-20 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
GB202018468D0
(en)
|
2020-11-24 |
2021-01-06 |
Index Pharmaceuticals Ab |
New therapy
|
CN117500815A
(zh)
|
2021-06-18 |
2024-02-02 |
Ionis制药公司 |
用于降低ifnar1表达的化合物和方法
|
EP4147688A1
(de)
|
2021-09-09 |
2023-03-15 |
InDex Pharmaceuticals AB |
Klistierformulierung
|
WO2023168427A1
(en)
|
2022-03-03 |
2023-09-07 |
Yale University |
Compositions and methods for delivering therapeutic polynucleotides for exon skipping
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024044352A1
(en)
|
2022-08-26 |
2024-02-29 |
The General Hospital Corporation |
Methods and compositions for prognosis and treatment of dilated cardiomyopathy and heart failure
|